{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:46:24Z","timestamp":1760985984650,"version":"3.37.3"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08DK098623","R03EB015955-01"],"award-info":[{"award-number":["K08DK098623","R03EB015955-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DeNardo Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s12012-021-09638-1","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T04:35:30Z","timestamp":1612845330000},"page":"265-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Parenteral Nutrition and Cardiotoxicity"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-118X","authenticated-orcid":false,"given":"Johan","family":"van Nispen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidul","family":"Murali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Samaddar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrashekhara","family":"Manithody","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"issue":"2","key":"9638_CR1","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/0019-5049.63637","volume":"54","author":"KV Chowdary","year":"2010","unstructured":"Chowdary, K. V., & Reddy, P. N. (2010). Parenteral nutrition: Revisited. Indian Journal of Anaesthesia, 54(2), 95\u2013103.","journal-title":"Indian Journal of Anaesthesia"},{"issue":"6","key":"9638_CR2","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/S1499-3872(12)60229-X","volume":"11","author":"ZW Xu","year":"2012","unstructured":"Xu, Z. W., & Li, Y. S. (2012). Pathogenesis and treatment of parenteral nutrition-associated liver disease. Hepatobiliary & Pancreatic Diseases International, 11(6), 586\u2013593.","journal-title":"Hepatobiliary & Pancreatic Diseases International"},{"issue":"3","key":"9638_CR3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/BF02537290","volume":"22","author":"M Martinez","year":"1987","unstructured":"Martinez, M., & Ballabriga, A. (1987). Effects of parenteral nutrition with high doses of linoleate on the developing human liver and brain. Lipids, 22(3), 133\u2013138.","journal-title":"Lipids"},{"issue":"4","key":"9638_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0148607100024004223","volume":"24","author":"DB Bertinet","year":"2000","unstructured":"Bertinet, D. B., et al. (2000). Brain manganese deposition and blood levels in patients undergoing home parenteral nutrition. JPEN Journal of Parenteral and Enteral Nutrition, 24(4), 223\u2013227.","journal-title":"JPEN Journal of Parenteral and Enteral Nutrition"},{"issue":"5","key":"9638_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3109\/15563650.2016.1151528","volume":"54","author":"BD Hayes","year":"2016","unstructured":"Hayes, B. D., et al. (2016). Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration. Clinical Toxicology (Philadelphia, PA), 54(5), 365\u2013404.","journal-title":"Clinical Toxicology (Philadelphia, PA)"},{"issue":"6","key":"9638_CR6","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1177\/0148607183007006534","volume":"7","author":"RM Abel","year":"1983","unstructured":"Abel, R. M., Fisch, D., & Grossman, M. L. (1983). Hemodynamic effects of intravenous 20% soy oil emulsion following coronary bypass surgery. JPEN Journal of Parenteral and Enteral Nutrition, 7(6), 534\u2013540.","journal-title":"JPEN Journal of Parenteral and Enteral Nutrition"},{"issue":"8","key":"9638_CR7","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1097\/00003246-200108000-00012","volume":"29","author":"U Suchner","year":"2001","unstructured":"Suchner, U., et al. (2001). Effects of intravenous fat emulsions on lung function in patients with acute respiratory distress syndrome or sepsis. Critical Care Medicine, 29(8), 1569\u20131574.","journal-title":"Critical Care Medicine"},{"issue":"1","key":"9638_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/ajcn\/73.1.27","volume":"73","author":"R Marfella","year":"2001","unstructured":"Marfella, R., et al. (2001). Elevated plasma fatty acid concentrations prolong cardiac repolarization in healthy subjects. American Journal of Clinical Nutrition, 73(1), 27\u201330.","journal-title":"American Journal of Clinical Nutrition"},{"issue":"3","key":"9638_CR9","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1136\/adc.53.3.218","volume":"53","author":"AJ Barson","year":"1978","unstructured":"Barson, A. J., Chistwick, M. L., & Doig, C. M. (1978). Fat embolism in infancy after intravenous fat infusions. Archives of Disease in Childhood, 53(3), 218\u2013223.","journal-title":"Archives of Disease in Childhood"},{"issue":"7","key":"9638_CR10","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1136\/adc.61.7.702","volume":"61","author":"G Hulman","year":"1986","unstructured":"Hulman, G., & Levene, M. (1986). Intralipid microemboli. Archives of Disease in Childhood, 61(7), 702\u2013703.","journal-title":"Archives of Disease in Childhood"},{"issue":"3","key":"9638_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s13181-014-0382-7","volume":"10","author":"JB Cole","year":"2014","unstructured":"Cole, J. B., Stellpflug, S. J., & Engebretsen, K. M. (2014). Asystole immediately following intravenous fat emulsion for overdose. Journal of Medical Toxicology, 10(3), 307\u2013310.","journal-title":"Journal of Medical Toxicology"},{"issue":"802","key":"9638_CR12","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/pgmj.68.802.629","volume":"68","author":"DP Naidoo","year":"1992","unstructured":"Naidoo, D. P., Singh, B., & Haffejee, A. (1992). Cardiovascular complications of parenteral nutrition. Postgraduate Medical Journal, 68(802), 629\u2013633.","journal-title":"Postgraduate Medical Journal"},{"issue":"11","key":"9638_CR13","first-page":"546","volume":"75","author":"DP Naidoo","year":"1989","unstructured":"Naidoo, D. P., et al. (1989). Acute pernicious beriberi in a patient receiving parenteral nutrition. A case report. South African Medical Journal, 75(11), 546\u2013548.","journal-title":"South African Medical Journal"},{"issue":"2","key":"9638_CR14","first-page":"163","volume":"43","author":"M Warren","year":"2013","unstructured":"Warren, M., et al. (2013). Pericardial effusion and cardiac tamponade in neonates: Sudden unexpected death associated with total parenteral nutrition via central venous catheterization. Annals of Clinical and Laboratory Science, 43(2), 163\u2013171.","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"4","key":"9638_CR15","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1097\/MPG.0000000000000828","volume":"61","author":"M Demircan","year":"2015","unstructured":"Demircan, M., et al. (2015). Damaging effects of total parenteral nutrition formula on vascular endothelium. Journal of Pediatric Gastroenterology and Nutrition, 61(4), 464\u2013468.","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"3","key":"9638_CR16","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/SHK.0b013e318162d0fe","volume":"30","author":"S Hagiwara","year":"2008","unstructured":"Hagiwara, S., et al. (2008). Effect of enteral versus parenteral nutrition on inflammation and cardiac function in a rat model of endotoxin-induced sepsis. Shock, 30(3), 280\u2013284.","journal-title":"Shock"},{"issue":"3","key":"9638_CR17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.jpedsurg.2019.04.027","volume":"55","author":"K Gurunluoglu","year":"2020","unstructured":"Gurunluoglu, K., et al. (2020). Investigation of the cardiotoxic effects of parenteral nutrition in rabbits. Journal of Pediatric Surgery, 55(3), 465\u2013474.","journal-title":"Journal of Pediatric Surgery"},{"issue":"2","key":"9638_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.plefa.2005.04.015","volume":"73","author":"A Hasanoglu","year":"2005","unstructured":"Hasanoglu, A., et al. (2005). Free oxygen radical-induced lipid peroxidation and antioxidant in infants receiving total parenteral nutrition. Prostaglandins Leukotrienes and Essential Fatty Acids, 73(2), 99\u2013102.","journal-title":"Prostaglandins Leukotrienes and Essential Fatty Acids"},{"issue":"6","key":"9638_CR19","doi-asserted-by":"publisher","first-page":"e9537","DOI":"10.1097\/MD.0000000000009537","volume":"97","author":"J Ma","year":"2018","unstructured":"Ma, J., et al. (2018). Hyperglycemia is associated with cardiac complications in elderly nondiabetic patients receiving total parenteral nutrition. Medicine (Baltimore), 97(6), e9537.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"9638_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11892-012-0335-y","volume":"13","author":"AR Gosmanov","year":"2013","unstructured":"Gosmanov, A. R., & Umpierrez, G. E. (2013). Management of hyperglycemia during enteral and parenteral nutrition therapy. Current Diabetes Reports, 13(1), 155\u2013162.","journal-title":"Current Diabetes Reports"},{"issue":"5","key":"9638_CR21","doi-asserted-by":"publisher","first-page":"450","DOI":"10.4162\/nrp.2011.5.5.450","volume":"5","author":"H Lee","year":"2011","unstructured":"Lee, H., Koh, S. O., & Park, M. S. (2011). Higher dextrose delivery via TPN related to the development of hyperglycemia in non-diabetic critically ill patients. Nutrition Research Practice, 5(5), 450\u2013454.","journal-title":"Nutrition Research Practice"},{"issue":"10","key":"9638_CR22","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.2337\/diacare.28.10.2367","volume":"28","author":"NW Cheung","year":"2005","unstructured":"Cheung, N. W., et al. (2005). Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care, 28(10), 2367\u20132371.","journal-title":"Diabetes Care"},{"issue":"5","key":"9638_CR23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/MAJ.0b013e3180536b26","volume":"333","author":"LY Lin","year":"2007","unstructured":"Lin, L. Y., et al. (2007). Hyperglycemia correlates with outcomes in patients receiving total parenteral nutrition. American Journal of the Medical Sciences, 333(5), 261\u2013265.","journal-title":"American Journal of the Medical Sciences"},{"issue":"1","key":"9638_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","volume":"416","author":"SS Korshunov","year":"1997","unstructured":"Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997). High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Letters, 416(1), 15\u201318.","journal-title":"FEBS Letters"},{"issue":"6","key":"9638_CR25","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","volume":"54","author":"M Brownlee","year":"2005","unstructured":"Brownlee, M. (2005). The pathobiology of diabetic complications: A unifying mechanism. Diabetes, 54(6), 1615\u20131625.","journal-title":"Diabetes"},{"issue":"2","key":"9638_CR26","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41419-017-0135-z","volume":"9","author":"CMO Volpe","year":"2018","unstructured":"Volpe, C. M. O., et al. (2018). Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death & Disease, 9(2), 119.","journal-title":"Cell Death & Disease"},{"issue":"7","key":"9638_CR27","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1517\/14728222.12.7.871","volume":"12","author":"JA Nogueira-Machado","year":"2008","unstructured":"Nogueira-Machado, J. A., & Chaves, M. M. (2008). From hyperglycemia to AGE-RAGE interaction on the cell surface: A dangerous metabolic route for diabetic patients. Expert Opinion on Therapeutic Targets, 12(7), 871\u2013882.","journal-title":"Expert Opinion on Therapeutic Targets"},{"issue":"6","key":"9638_CR28","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.mehy.2015.08.019","volume":"85","author":"T Krakauer","year":"2015","unstructured":"Krakauer, T. (2015). Inflammasome, mTORC1 activation, and metabolic derangement contribute to the susceptibility of diabetics to infections. Medical Hypotheses, 85(6), 997\u20131001.","journal-title":"Medical Hypotheses"},{"issue":"2","key":"9638_CR29","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.yjmcc.2006.05.023","volume":"42","author":"PF Mount","year":"2007","unstructured":"Mount, P. F., Kemp, B. E., & Power, D. A. (2007). Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. Journal of Molecular and Cellular Cardiology, 42(2), 271\u2013279.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"7","key":"9638_CR30","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s00424-016-1839-0","volume":"468","author":"M Siragusa","year":"2016","unstructured":"Siragusa, M., & Fleming, I. (2016). The eNOS signalosome and its link to endothelial dysfunction. Pflugers Archiv European Journal of Physiology, 468(7), 1125\u20131137.","journal-title":"Pflugers Archiv European Journal of Physiology"},{"issue":"1","key":"9638_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1161\/01.CIR.96.1.25","volume":"96","author":"F Cosentino","year":"1997","unstructured":"Cosentino, F., et al. (1997). High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation, 96(1), 25\u201328.","journal-title":"Circulation"},{"issue":"3","key":"9638_CR32","doi-asserted-by":"publisher","first-page":"H981","DOI":"10.1152\/ajpheart.2001.281.3.H981","volume":"281","author":"ZS Katusic","year":"2001","unstructured":"Katusic, Z. S. (2001). Vascular endothelial dysfunction: Does tetrahydrobiopterin play a role? American Journal of Physiology-Heart and Circulatory Physiology, 281(3), H981\u2013H986.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"9638_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.niox.2019.04.007","volume":"89","author":"V Gebhart","year":"2019","unstructured":"Gebhart, V., et al. (2019). Site and mechanism of uncoupling of nitric-oxide synthase: Uncoupling by monomerization and other misconceptions. Nitric Oxide, 89, 14\u201321.","journal-title":"Nitric Oxide"},{"issue":"32","key":"9638_CR34","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.2174\/1381612811319320005","volume":"19","author":"TV Fiorentino","year":"2013","unstructured":"Fiorentino, T. V., et al. (2013). Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Current Pharmaceutical Design, 19(32), 5695\u20135703.","journal-title":"Current Pharmaceutical Design"},{"key":"9638_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mvr.2018.03.012","volume":"119","author":"MF Yuyun","year":"2018","unstructured":"Yuyun, M. F., Ng, L. L., & Ng, G. A. (2018). Endothelial dysfunction, endothelial nitric oxide bioavailability, tetrahydrobiopterin, and 5-methyltetrahydrofolate in cardiovascular disease. Where are we with therapy? Microvascular Research, 119, 7\u201312.","journal-title":"Microvascular Research"},{"issue":"Pt 2","key":"9638_CR36","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1042\/bj2980249","volume":"298","author":"RG Knowles","year":"1994","unstructured":"Knowles, R. G., & Moncada, S. (1994). Nitric oxide synthases in mammals. The Biochemical Journal, 298(Pt 2), 249\u2013258.","journal-title":"The Biochemical Journal"},{"key":"9638_CR37","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2174\/1874192401105010153","volume":"5","author":"SS Soski\u0107","year":"2011","unstructured":"Soski\u0107, S. S., et al. (2011). Regulation of inducible nitric oxide synthase (iNOS) and its potential role in insulin resistance, diabetes and heart failure. The Open Cardiovascular Medicine Journal, 5, 153\u2013163.","journal-title":"The Open Cardiovascular Medicine Journal"},{"issue":"2","key":"9638_CR38","doi-asserted-by":"publisher","first-page":"185.e5","DOI":"10.1016\/j.ajog.2010.05.003","volume":"203","author":"P Yang","year":"2010","unstructured":"Yang, P., Cao, Y., & Li, H. (2010). Hyperglycemia induces inducible nitric oxide synthase gene expression and consequent nitrosative stress via c-Jun N-terminal kinase activation. American Journal of Obstetrics and Gynecology, 203(2), 185.e5\u201311.","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"9638_CR39","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2014.10.575","volume":"79","author":"E McNeill","year":"2015","unstructured":"McNeill, E., et al. (2015). Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation. Free Radical Biology Medicine, 79, 206\u2013216.","journal-title":"Free Radical Biology Medicine"},{"issue":"9","key":"9638_CR40","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1096\/fj.01-0890fje","volume":"16","author":"A Huisman","year":"2002","unstructured":"Huisman, A., et al. (2002). Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: Modulation of inducible nitric oxide synthase. The FASEB Journal, 16(9), 1135\u20131137.","journal-title":"The FASEB Journal"},{"issue":"35","key":"9638_CR41","doi-asserted-by":"publisher","first-page":"22635","DOI":"10.1074\/jbc.273.35.22635","volume":"273","author":"Y Xia","year":"1998","unstructured":"Xia, Y., et al. (1998). Inducible nitric-oxide synthase generates superoxide from the reductase domain. Journal of Biological Chemistry, 273(35), 22635\u201322639.","journal-title":"Journal of Biological Chemistry"},{"key":"9638_CR42","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.biopha.2017.06.036","volume":"93","author":"M Lind","year":"2017","unstructured":"Lind, M., et al. (2017). Inducible nitric oxide synthase: Good or bad? Biomedicine & Pharmacotherapy, 93, 370\u2013375.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"5","key":"9638_CR43","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.2337\/diabetes.54.5.1340","volume":"54","author":"M Fujimoto","year":"2005","unstructured":"Fujimoto, M., et al. (2005). A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes, 54(5), 1340\u20131348.","journal-title":"Diabetes"},{"issue":"2","key":"9638_CR44","doi-asserted-by":"publisher","first-page":"L434","DOI":"10.1152\/ajplung.00075.2003","volume":"285","author":"M Konstantoulaki","year":"2003","unstructured":"Konstantoulaki, M., Kouklis, P., & Malik, A. B. (2003). Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin. American Journal of Physiology. Lung Cellular and Molecular Physiology, 285(2), L434\u2013L442.","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"issue":"3","key":"9638_CR45","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ceca.2016.02.002","volume":"60","author":"A Di","year":"2016","unstructured":"Di, A., Mehta, D., & Malik, A. B. (2016). ROS-activated calcium signaling mechanisms regulating endothelial barrier function. Cell Calcium, 60(3), 163\u2013171.","journal-title":"Cell Calcium"},{"issue":"5","key":"9638_CR46","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1161\/01.RES.88.5.529","volume":"88","author":"T Ide","year":"2001","unstructured":"Ide, T., et al. (2001). Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circulation Research, 88(5), 529\u2013535.","journal-title":"Circulation Research"},{"issue":"2","key":"9638_CR47","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.coph.2006.01.001","volume":"6","author":"P Pacher","year":"2006","unstructured":"Pacher, P., & Szab\u00f3, C. (2006). Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. Current Opinion in Pharmacology, 6(2), 136\u2013141.","journal-title":"Current Opinion in Pharmacology"},{"issue":"4","key":"9638_CR48","doi-asserted-by":"publisher","first-page":"C719","DOI":"10.1152\/ajpcell.2001.280.4.C719","volume":"280","author":"H Lum","year":"2001","unstructured":"Lum, H., & Roebuck, K. A. (2001). Oxidant stress and endothelial cell dysfunction. American Journal of Physiology. Cell Physiology, 280(4), C719\u2013C741.","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"6","key":"9638_CR49","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.tips.2005.04.003","volume":"26","author":"P Pacher","year":"2005","unstructured":"Pacher, P., et al. (2005). Nitrosative stress and pharmacological modulation of heart failure. Trends in Pharmacological Sciences, 26(6), 302\u2013310.","journal-title":"Trends in Pharmacological Sciences"},{"issue":"3","key":"9638_CR50","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.resp.2010.08.019","volume":"174","author":"S Kar","year":"2010","unstructured":"Kar, S., et al. (2010). Redox-control of matrix metalloproteinase-1: A critical link between free radicals, matrix remodeling and degenerative disease. Respiratory Physiology & Neurobiology, 174(3), 299\u2013306.","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"7","key":"9638_CR51","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1172\/JCI8040","volume":"106","author":"HE Kim","year":"2000","unstructured":"Kim, H. E., et al. (2000). Disruption of the myocardial extracellular matrix leads to cardiac dysfunction. Journal of Clinical Investigation, 106(7), 857\u2013866.","journal-title":"Journal of Clinical Investigation"},{"issue":"6","key":"9638_CR52","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1067\/mtc.2002.121687","volume":"123","author":"S Verma","year":"2002","unstructured":"Verma, S., et al. (2002). Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation. Journal of Thoracic and Cardiovascular Surgery, 123(6), 1074\u20131083.","journal-title":"Journal of Thoracic and Cardiovascular Surgery"},{"issue":"18","key":"9638_CR53","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1089\/ars.2013.5566","volume":"20","author":"JK Bendall","year":"2014","unstructured":"Bendall, J. K., et al. (2014). Tetrahydrobiopterin in cardiovascular health and disease. Antioxidants & Redox Signaling, 20(18), 3040\u20133077.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"4","key":"9638_CR54","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.cardiores.2004.10.040","volume":"65","author":"S Cai","year":"2005","unstructured":"Cai, S., Khoo, J., & Channon, K. M. (2005). Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. Cardiovascular Research, 65(4), 823\u2013831.","journal-title":"Cardiovascular Research"},{"issue":"12","key":"9638_CR55","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/j.ophtha.2006.07.032","volume":"113","author":"P-D Group","year":"2006","unstructured":"Group, P.-D., et al. (2006). Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology, 113(12), 2221\u20132230.","journal-title":"Ophthalmology"},{"issue":"3","key":"9638_CR56","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3132\/dvdr.2006.026","volume":"3","author":"I Idris","year":"2006","unstructured":"Idris, I., & Donnelly, R. (2006). Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy. Diabetes and Vascular Disease Research, 3(3), 172\u2013178.","journal-title":"Diabetes and Vascular Disease Research"},{"issue":"2","key":"9638_CR57","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1042\/BJ20140881","volume":"466","author":"CH Wilson","year":"2015","unstructured":"Wilson, C. H., et al. (2015). Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism. The Biochemical Journal, 466(2), 379\u2013390.","journal-title":"The Biochemical Journal"},{"issue":"1","key":"9638_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbabio.2004.03.008","volume":"1657","author":"AR Cross","year":"2004","unstructured":"Cross, A. R., & Segal, A. W. (2004). The NADPH oxidase of professional phagocytes\u2013prototype of the NOX electron transport chain systems. Biochimica et Biophysica Acta, 1657(1), 1\u201322.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"10","key":"9638_CR59","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1089\/ars.2009.2585","volume":"11","author":"V Jaquet","year":"2009","unstructured":"Jaquet, V., et al. (2009). Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxidants & Redox Signaling, 11(10), 2535\u20132552.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"11","key":"9638_CR60","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1161\/STROKEAHA.107.489765","volume":"38","author":"T Kahles","year":"2007","unstructured":"Kahles, T., et al. (2007). NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke, 38(11), 3000\u20133006.","journal-title":"Stroke"},{"issue":"6","key":"9638_CR61","doi-asserted-by":"publisher","first-page":"F1348","DOI":"10.1152\/ajprenal.00028.2010","volume":"299","author":"M Sedeek","year":"2010","unstructured":"Sedeek, M., et al. (2010). Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: Implications in type 2 diabetic nephropathy. American Journal of Physiology. Renal Physiology, 299(6), F1348\u2013F1358.","journal-title":"American Journal of Physiology. Renal Physiology"},{"issue":"1","key":"9638_CR62","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/FJC.0b013e318063e820","volume":"50","author":"HC Williams","year":"2007","unstructured":"Williams, H. C., & Griendling, K. K. (2007). NADPH oxidase inhibitors: New antihypertensive agents? Journal of Cardiovascular Pharmacology, 50(1), 9\u201316.","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"9638_CR63","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.biopha.2016.11.134","volume":"86","author":"W Wang","year":"2017","unstructured":"Wang, W., et al. (2017). Rutin protects endothelial dysfunction by disturbing Nox4 and ROS-sensitive NLRP3 inflammasome. Biomedicine & Pharmacotherapy, 86, 32\u201340.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"5","key":"9638_CR64","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s00125-017-4215-5","volume":"60","author":"SP Gray","year":"2017","unstructured":"Gray, S. P., et al. (2017). Combined NOX1\/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia, 60(5), 927\u2013937.","journal-title":"Diabetologia"},{"issue":"3","key":"9638_CR65","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1159\/000430266","volume":"36","author":"D Zheng","year":"2015","unstructured":"Zheng, D., et al. (2015). Exogenous hydrogen sulfide attenuates cardiac fibrosis through reactive oxygen species signal pathways in experimental diabetes mellitus models. Cellular Physiology and Biochemistry, 36(3), 917\u2013929.","journal-title":"Cellular Physiology and Biochemistry"},{"issue":"7","key":"9638_CR66","doi-asserted-by":"publisher","first-page":"4145","DOI":"10.1074\/jbc.M113.521062","volume":"289","author":"A Das","year":"2014","unstructured":"Das, A., et al. (2014). Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: Potential role of attenuated oxidative stress and altered contractile protein expression. Journal of Biological Chemistry, 289(7), 4145\u20134160.","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"9638_CR67","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.clnu.2012.08.006","volume":"32","author":"A Esteghamati","year":"2013","unstructured":"Esteghamati, A., et al. (2013). Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial. Clinical Nutrition, 32(2), 179\u2013185.","journal-title":"Clinical Nutrition"},{"issue":"11","key":"9638_CR68","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/ki.2010.41","volume":"77","author":"ZH Chen","year":"2010","unstructured":"Chen, Z. H., et al. (2010). Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro. Kidney International, 77(11), 974\u2013988.","journal-title":"Kidney International"},{"issue":"4","key":"9638_CR69","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1161\/HYPERTENSIONAHA.109.129353","volume":"54","author":"A Fortuno","year":"2009","unstructured":"Fortuno, A., et al. (2009). Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: Potential clinical implications in hypertension. Hypertension, 54(4), 744\u2013750.","journal-title":"Hypertension"},{"issue":"3","key":"9638_CR70","first-page":"236","volume":"41","author":"R Meng","year":"2011","unstructured":"Meng, R., et al. (2011). Anti-oxidative effect of apocynin on insulin resistance in high-fat diet mice. Annals of Clinical and Laboratory Science, 41(3), 236\u2013243.","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"2","key":"9638_CR71","first-page":"329","volume":"10","author":"A Taye","year":"2011","unstructured":"Taye, A., & Morawietz, H. (2011). Spironolactone inhibits NADPH oxidase-induced oxidative stress and enhances eNOS in human endothelial cells. Iranian Journal of Pharmaceutical Research, 10(2), 329\u2013337.","journal-title":"Iranian Journal of Pharmaceutical Research"},{"issue":"34","key":"9638_CR72","doi-asserted-by":"publisher","first-page":"26545","DOI":"10.1074\/jbc.M110.143917","volume":"285","author":"AE Vendrov","year":"2010","unstructured":"Vendrov, A. E., et al. (2010). NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis. Journal of Biological Chemistry, 285(34), 26545\u201326557.","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"9638_CR73","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.dld.2013.10.021","volume":"46","author":"H Duboc","year":"2014","unstructured":"Duboc, H., Tach\u00e9, Y., & Hofmann, A. F. (2014). The bile acid TGR5 membrane receptor: From basic research to clinical application. Digstive and Liver Disease, 46(4), 302\u2013312.","journal-title":"Digstive and Liver Disease"},{"issue":"11","key":"9638_CR74","doi-asserted-by":"publisher","first-page":"9435","DOI":"10.1074\/jbc.M209706200","volume":"278","author":"Y Kawamata","year":"2003","unstructured":"Kawamata, Y., et al. (2003). A G protein-coupled receptor responsive to bile acids. Journal of Biological Chemistry, 278(11), 9435\u20139440.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"9638_CR75","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1677\/joe.1.06546","volume":"191","author":"T Maruyama","year":"2006","unstructured":"Maruyama, T., et al. (2006). Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1\/M-Bar) in mice. Journal of Endocrinology, 191(1), 197\u2013205.","journal-title":"Journal of Endocrinology"},{"issue":"7075","key":"9638_CR76","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nature04330","volume":"439","author":"M Watanabe","year":"2006","unstructured":"Watanabe, M., et al. (2006). Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature, 439(7075), 484\u2013489.","journal-title":"Nature"},{"issue":"5","key":"9638_CR77","doi-asserted-by":"publisher","first-page":"e12462","DOI":"10.1111\/1755-5922.12462","volume":"36","author":"Z Eblimit","year":"2018","unstructured":"Eblimit, Z., et al. (2018). TGR5 activation induces cytoprotective changes in the heart and improves myocardial adaptability to physiologic, inotropic, and pressure-induced stress in mice. Cardiovascular Therapeutics, 36(5), e12462.","journal-title":"Cardiovascular Therapeutics"},{"issue":"3","key":"9638_CR78","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.bbrc.2012.09.104","volume":"427","author":"DP Kumar","year":"2012","unstructured":"Kumar, D. P., et al. (2012). Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic beta cells. Biochemical and Biophysical Research Communications, 427(3), 600\u2013605.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"9638_CR79","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/0148607115583536","volume":"40","author":"AK Jain","year":"2016","unstructured":"Jain, A. K., et al. (2016). Oleanolic acid improves gut atrophy induced by parenteral nutrition. JPEN Journal of Parenteral and Enteral Nutrition, 40(1), 67\u201372.","journal-title":"JPEN Journal of Parenteral and Enteral Nutrition"},{"issue":"4","key":"9638_CR80","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/hep.24525","volume":"54","author":"YD Wang","year":"2011","unstructured":"Wang, Y. D., et al. (2011). The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor \u03ba light-chain enhancer of activated B cells (NF-\u03baB) in mice. Hepatology, 54(4), 1421\u20131432.","journal-title":"Hepatology"},{"issue":"12","key":"9638_CR81","doi-asserted-by":"publisher","first-page":"5424","DOI":"10.1172\/JCI76289","volume":"124","author":"A Perino","year":"2014","unstructured":"Perino, A., et al. (2014). TGR5 reduces macrophage migration through mTOR-induced C\/EBP\u03b2 differential translation. Journal of Clinical Investigation, 124(12), 5424\u20135436.","journal-title":"Journal of Clinical Investigation"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09638-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-021-09638-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09638-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T03:19:32Z","timestamp":1674962372000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-021-09638-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,7]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["9638"],"URL":"https:\/\/doi.org\/10.1007\/s12012-021-09638-1","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"type":"print","value":"1530-7905"},{"type":"electronic","value":"1559-0259"}],"subject":[],"published":{"date-parts":[[2021,2,7]]},"assertion":[{"value":"4 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors have no conflicts of interest to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This review did not involve experimentation on animal or human subjects; all relevant ethical standards regarding the preparation of this manuscript were upheld.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}