{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:20:04Z","timestamp":1781835604588,"version":"3.54.5"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230004"],"award-info":[{"award-number":["81230004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s12012-021-09650-5","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T13:04:18Z","timestamp":1619442258000},"page":"572-581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiomyocyte-Specific COMMD1 Deletion Suppresses Ischemia-Induced Myocardial Apoptosis"],"prefix":"10.1007","volume":"21","author":[{"given":"Chen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8449-7904","authenticated-orcid":false,"given":"Y. James","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"9650_CR1","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1074\/jbc.M111.302216","volume":"287","author":"S Materia","year":"2012","unstructured":"Materia, S., Cater, M. A., Klomp, L. W., Mercer, J. F., & La Fontaine, S. (2012). Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. The Journal of biological chemistry, 287, 2485\u20132499.","journal-title":"The Journal of biological chemistry"},{"key":"9650_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1091\/mbc.e14-06-1073","volume":"26","author":"CA Phillips-Krawczak","year":"2015","unstructured":"Phillips-Krawczak, C. A., Singla, A., Starokadomskyy, P., Deng, Z., Osborne, D. G., Li, H., Dick, C. J., Gomez, T. S., Koenecke, M., Zhang, J. S., Dai, H., Sifuentes-Dominguez, L. F., Geng, L. N., Kaufmann, S. H., Hein, M. Y., Wallis, M., McGaughran, J., Gecz, J., Sluis, B. V., \u2026 Burstein, E. (2015). COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Molecular biology of the cell, 26, 91\u2013103.","journal-title":"Molecular biology of the cell"},{"key":"9650_CR3","doi-asserted-by":"crossref","unstructured":"Campbell, K. J., & Perkins, N. D. (2006). Regulation of NF-kappaB function.\u00a0Biochemical Society symposium, 165\u2013180.","DOI":"10.1042\/bss0730165"},{"key":"9650_CR4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1158\/0008-5472.CAN-09-1397","volume":"70","author":"HC Thoms","year":"2010","unstructured":"Thoms, H. C., Loveridge, C. J., Simpson, J., Clipson, A., Reinhardt, K., Dunlop, M. G., & Stark, L. A. (2010). Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. Cancer research, 70, 139\u2013149.","journal-title":"Cancer research"},{"key":"9650_CR5","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1016\/j.bbadis.2013.09.014","volume":"1832","author":"P Bartuzi","year":"2013","unstructured":"Bartuzi, P., Hofker, M. H., & van de Sluis, B. (2013). Tuning NF-\u03baB activity: a touch of COMMD proteins. Biochimica et biophysica acta, 1832, 2315\u20132321.","journal-title":"Biochimica et biophysica acta"},{"key":"9650_CR6","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1172\/JCI40583","volume":"120","author":"B van de Sluis","year":"2010","unstructured":"van de Sluis, B., Mao, X., Zhai, Y., Groot, A. J., Vermeulen, J. F., van der Wall, E., van Diest, P. J., Hofker, M. H., Wijmenga, C., Klomp, L. W., Cho, K. R., Fearon, E. R., Vooijs, M., & Burstein, E. (2010). COMMD1 disrupts HIF-1alpha\/beta dimerization and inhibits human tumor cell invasion. The Journal of clinical investigation, 120, 2119\u20132130.","journal-title":"The Journal of clinical investigation"},{"key":"9650_CR7","doi-asserted-by":"publisher","first-page":"28991","DOI":"10.1074\/jbc.M110.101477","volume":"285","author":"WI Vonk","year":"2010","unstructured":"Vonk, W. I., Wijmenga, C., Berger, R., van de Sluis, B., & Klomp, L. W. (2010). Cu, Zn superoxide dismutase maturation and activity are regulated by COMMD1. The Journal of biological chemistry, 285, 28991\u201329000.","journal-title":"The Journal of biological chemistry"},{"key":"9650_CR8","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1177\/1535370218773055","volume":"243","author":"K Li","year":"2018","unstructured":"Li, K., Li, C., Xiao, Y., Wang, T., & James Kang, Y. (2018). The loss of copper is associated with the increase in copper metabolism MURR domain 1 in ischemic hearts of mice. Experimental biology and medicine (Maywood, N.J.), 243, 780\u2013785.","journal-title":"Experimental biology and medicine (Maywood, N.J.)"},{"key":"9650_CR9","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1177\/1535370220969844","volume":"246","author":"C Li","year":"2021","unstructured":"Li, C., Wang, T., Xiao, Y., Li, K., Meng, X., & James, Kang Y. (2021). COMMD1 upregulation is involved in copper efflux from ischemic hearts. Experimental biology and medicine (Maywood, N.J.), 246, 607\u2013616.","journal-title":"Experimental biology and medicine (Maywood, N.J.)"},{"key":"9650_CR10","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.3390\/ijms20102418","volume":"20","author":"J Zhang","year":"2019","unstructured":"Zhang, J., Qiu, W., Ma, J., Wang, Y., Hu, Z., Long, K., Wang, X., Jin, L., Tang, Q., Tang, G., Zhu, L., Li, X., Shuai, S., & Li, M. (2019). miR-27a-5p Attenuates Hypoxia-induced Rat Cardiomyocyte Injury by Inhibiting Atg7. International journal of molecular sciences, 20, 2418.","journal-title":"International journal of molecular sciences"},{"key":"9650_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1161\/01.RES.86.4.371","volume":"86","author":"A Haunstetter","year":"2000","unstructured":"Haunstetter, A., & Izumo, S. (2000). Toward antiapoptosis as a new treatment modality. Circulation research, 86, 371\u2013376.","journal-title":"Circulation research"},{"key":"9650_CR12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1161\/01.CIR.97.3.276","volume":"97","author":"H Yaoita","year":"1998","unstructured":"Yaoita, H., Ogawa, K., Maehara, K., & Maruyama, Y. (1998). Attenuation of ischemia\/reperfusion injury in rats by a caspase inhibitor. Circulation, 97, 276\u2013281.","journal-title":"Circulation"},{"key":"9650_CR13","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jss.2004.09.017","volume":"124","author":"LB Balsam","year":"2005","unstructured":"Balsam, L. B., Kofidis, T., & Robbins, R. C. (2005). Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction. The Journal of surgical research, 124, 194\u2013200.","journal-title":"The Journal of surgical research"},{"key":"9650_CR14","first-page":"86","volume":"74","author":"J Kajstura","year":"1996","unstructured":"Kajstura, J., Cheng, W., Reiss, K., Clark, W. A., Sonnenblick, E. H., Krajewski, S., Reed, J. C., Olivetti, G., & Anversa, P. (1996). Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Laboratory investigation; a journal of technical methods and pathology, 74, 86\u2013107.","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"key":"9650_CR15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1006\/jmcc.1999.1067","volume":"32","author":"E Takashi","year":"2000","unstructured":"Takashi, E., & Ashraf, M. (2000). Pathologic assessment of myocardial cell necrosis and apoptosis after ischemia and reperfusion with molecular and morphological markers. Journal of molecular and cellular cardiology, 32, 209\u2013224.","journal-title":"Journal of molecular and cellular cardiology"},{"key":"9650_CR16","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2217\/fca.12.58","volume":"8","author":"KA Webster","year":"2012","unstructured":"Webster, K. A. (2012). Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species. Future cardiology, 8, 863\u2013884.","journal-title":"Future cardiology"},{"key":"9650_CR17","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00540-015-2035-7","volume":"29","author":"H Liang","year":"2015","unstructured":"Liang, H., Yang, C. X., Zhang, B., Wang, H. B., Liu, H. Z., Lai, X. H., Liao, M. J., & Zhang, T. (2015). Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1\u03b1. Journal of anesthesia, 29, 821\u2013830.","journal-title":"Journal of anesthesia"},{"issue":"2","key":"9650_CR18","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/sj.cdd.4401826","volume":"13","author":"AD Schimmer","year":"2006","unstructured":"Schimmer, A. D., Dalili, S., Batey, R. A., & Riedl, S. J. (2006). Targeting XIAP for the treatment of malignancy. Cell death and differentiation, 13(2), 179\u2013188.","journal-title":"Cell death and differentiation"},{"key":"9650_CR19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/cdd.2009.81","volume":"17","author":"S Galb\u00e1n","year":"2010","unstructured":"Galb\u00e1n, S., & Duckett, C. S. (2010). XIAP as a ubiquitin ligase in cellular signaling. Cell death and differentiation, 17, 54\u201360.","journal-title":"Cell death and differentiation"},{"key":"9650_CR20","first-page":"164","volume":"17","author":"L Jiang","year":"2005","unstructured":"Jiang, L., Ning, Z., & Hong, T. (2005). The role of bc1-2 and bax as well as NF-kB on liver cancer cell apoptosis induced by resveratrol. Chinese Journal of Microecology, 17, 164\u2013165.","journal-title":"Chinese Journal of Microecology"},{"key":"9650_CR21","doi-asserted-by":"publisher","first-page":"8961","DOI":"10.1038\/sj.onc.1207230","volume":"22","author":"J Kucharczak","year":"2003","unstructured":"Kucharczak, J., Simmons, M. J., Fan, Y., & G\u00e9linas, C. (2003). To be, or not to be: NF-kappaB is the answer\u2013role of Rel\/NF-kappaB in the regulation of apoptosis. Oncogene, 22, 8961\u20138982.","journal-title":"Oncogene"},{"key":"9650_CR22","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/sj.emboj.7601489","volume":"26","author":"GN Maine","year":"2007","unstructured":"Maine, G. N., Mao, X., Komarck, C. M., & Burstein, E. (2007). COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. The EMBO journal, 26, 436\u2013447.","journal-title":"The EMBO journal"},{"key":"9650_CR23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/embor.2009.10","volume":"10","author":"H Geng","year":"2009","unstructured":"Geng, H., Wittwer, T., Dittrich-Breiholz, O., Kracht, M., & Schmitz, M. L. (2009). Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO reports, 10, 381\u2013386.","journal-title":"EMBO reports"},{"key":"9650_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/376167a0","volume":"376","author":"AA Beg","year":"1995","unstructured":"Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995). Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature, 376, 167\u2013170.","journal-title":"Nature"},{"key":"9650_CR25","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1128\/MCB.24.5.1823-1835.2004","volume":"24","author":"GR Panta","year":"2004","unstructured":"Panta, G. R., Kaur, S., Cavin, L. G., Cort\u00e9s, M. L., Mercurio, F., Lothstein, L., Sweatman, T. W., Israel, M., & Arsura, M. (2004). ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK\/extracellular signal-regulated kinase\/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Molecular and cellular biology, 24, 1823\u20131835.","journal-title":"Molecular and cellular biology"},{"key":"9650_CR26","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1126\/science.274.5288.782","volume":"274","author":"AA Beg","year":"1996","unstructured":"Beg, A. A., & Baltimore, D. (1996). An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science (New York, N.Y.), 274, 782\u2013784.","journal-title":"Science (New York, N.Y.)"},{"key":"9650_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.yjmcc.2013.08.003","volume":"64","author":"M Oikawa","year":"2013","unstructured":"Oikawa, M., Wu, M., Lim, S., Knight, W. E., Miller, C. L., Cai, Y., Lu, Y., Blaxall, B. C., Takeishi, Y., Abe, J., & Yan, C. (2013). Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. Journal of molecular and cellular cardiology, 64, 11\u201319.","journal-title":"Journal of molecular and cellular cardiology"},{"key":"9650_CR28","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1177\/1535370218813988","volume":"243","author":"J Liu","year":"2018","unstructured":"Liu, J., Chen, C., Liu, Y., Sun, X., Ding, X., Qiu, L., Han, P., & James Kang, Y. (2018). Feature Article: Trientine selectively delivers copper to the heart and suppresses pressure overload-induced cardiac hypertrophy in rats. Experimental biology and medicine (Maywood, N.J.), 243, 1141\u20131152.","journal-title":"Experimental biology and medicine (Maywood, N.J.)"},{"key":"9650_CR29","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ijcard.2017.12.097","volume":"266","author":"J Zhang","year":"2018","unstructured":"Zhang, J., Yu, L., Xu, Y., Liu, Y., Li, Z., Xue, X., Wan, S., & Wang, H. (2018). Long noncoding RNA upregulated in hypothermia treated cardiomyocytes protects against myocardial infarction through improving mitochondrial function. International journal of cardiology, 266, 213\u2013217.","journal-title":"International journal of cardiology"},{"key":"9650_CR30","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1093\/cvr\/cvy307","volume":"115","author":"J Zhang","year":"2019","unstructured":"Zhang, J., Sheng, J., Dong, L., Xu, Y., Yu, L., Liu, Y., Huang, X., Wan, S., Lan, H. Y., & Wang, H. (2019). Cardiomyocyte-specific loss of RNA polymerase II subunit 5-mediating protein causes myocardial dysfunction and heart failure. Cardiovascular research, 115, 1617\u20131628.","journal-title":"Cardiovascular research"},{"key":"9650_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12967-017-1191-y","volume":"15","author":"E Teringova","year":"2017","unstructured":"Teringova, E., & Tousek, P. (2017). Apoptosis in ischemic heart disease. Journal of translational medicine, 15, 87.","journal-title":"Journal of translational medicine"},{"key":"9650_CR32","first-page":"9583268","volume":"2016","author":"P Xia","year":"2016","unstructured":"Xia, P., Liu, Y., & Cheng, Z. (2016). Signaling Pathways in Cardiac Myocyte Apoptosis. BioMed research international, 2016, 9583268.","journal-title":"BioMed research international"},{"key":"9650_CR33","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.it.2012.06.004","volume":"33","author":"ST Beug","year":"2012","unstructured":"Beug, S. T., Cheung, H. H., LaCasse, E. C., & Korneluk, R. G. (2012). Modulation of immune signalling by inhibitors of apoptosis. Trends in immunology, 33, 535\u2013545.","journal-title":"Trends in immunology"},{"key":"9650_CR34","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jacc.2014.04.068","volume":"64","author":"F Ahmad","year":"2014","unstructured":"Ahmad, F., Lal, H., Zhou, J., Vagnozzi, R. J., Yu, J. E., Shang, X., Woodgett, J. R., Gao, E., & Force, T. (2014). Cardiomyocyte-specific deletion of Gsk3\u03b1 mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. Journal of the American College of Cardiology, 64, 696\u2013706.","journal-title":"Journal of the American College of Cardiology"},{"key":"9650_CR35","doi-asserted-by":"crossref","first-page":"I212","DOI":"10.1161\/01.cir.0000032907.33237.55","volume":"106","author":"S Chatterjee","year":"2002","unstructured":"Chatterjee, S., Stewart, A. S., Bish, L. T., Jayasankar, V., Kim, E. M., Pirolli, T., Burdick, J., Woo, Y. J., Gardner, T. J., & Sweeney, H. L. (2002). Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation, 106, I212\u2013I217.","journal-title":"Circulation"},{"key":"9650_CR36","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014). Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nature reviews. Molecular cell biology, 15, 49\u201363.","journal-title":"Nature reviews. Molecular cell biology"},{"key":"9650_CR37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1385\/CBB:47:1:11","volume":"47","author":"E Hochhauser","year":"2007","unstructured":"Hochhauser, E., Cheporko, Y., Yasovich, N., Pinchas, L., Offen, D., Barhum, Y., Pannet, H., Tobar, A., Vidne, B. A., & Birk, E. (2007). Bax deficiency reduces infarct size and improves long-term function after myocardial infarction. Cell biochemistry and biophysics, 47, 11\u201320.","journal-title":"Cell biochemistry and biophysics"},{"key":"9650_CR38","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/psc.2934","volume":"22","author":"S Astrada","year":"2016","unstructured":"Astrada, S., Gomez, Y., Barrera, E., Obal, G., Pritsch, O., Pantano, S., Vallesp\u00ed, M. G., & Bollati-Fogol\u00edn, M. (2016). Comparative analysis reveals amino acids critical for anticancer activity of peptide CIGB-552. Journal of peptide science\u202f: an official publication of the European Peptide Society, 22, 711\u2013722.","journal-title":"Journal of peptide science : an official publication of the European Peptide Society"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09650-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-021-09650-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09650-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,25]],"date-time":"2022-12-25T13:01:11Z","timestamp":1671973271000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-021-09650-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,26]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["9650"],"URL":"https:\/\/doi.org\/10.1007\/s12012-021-09650-5","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,26]]},"assertion":[{"value":"8 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author(s) declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.\u00a0Author Y James Kang is a member of the Editorial Board for <i>Cardiovascular Toxicology<\/i>. The paper was handled by the other Editor and has undergone rigorous peer review process. Author Y James Kang was not involved in the journal\u2019s review of, or decisions related to, this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}