{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:03:57Z","timestamp":1788282237349,"version":"build-2803163510"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s12012-021-09661-2","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:02:51Z","timestamp":1622034171000},"page":"710-720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3"],"prefix":"10.1007","volume":"21","author":[{"given":"Xiao-Jing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Qiang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"9661_CR1","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","volume":"37","author":"MF Piepoli","year":"2016","unstructured":"Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corra, U., Cosyns, B., Deaton, C., Graham, I., Hall, M. S., Hobbs, F. D. R., Lochen, M. L., Lollgen, H., Marques-Vidal, P., Perk, J., Prescott, E., Redon, J., Richter, D. J., et al. (2016). 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention and Rehabilitation (EACPR). European Heart Journal, 37, 2315\u20132381.","journal-title":"European Heart Journal"},{"key":"9661_CR2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1179\/2295333714Y.0000000069","volume":"69","author":"G Van Camp","year":"2014","unstructured":"Van Camp, G. (2014). Cardiovascular disease prevention. Acta clinica Belgica, 69, 407\u2013411.","journal-title":"Acta clinica Belgica"},{"key":"9661_CR3","first-page":"2018035","volume":"2020","author":"XY Wang","year":"2020","unstructured":"Wang, X. Y., Zhang, F., Zhang, C., Zheng, L. R., & Yang, J. (2020). The biomarkers for acute myocardial infarction and heart failure. BioMed Research International, 2020, 2018035.","journal-title":"BioMed Research International"},{"key":"9661_CR4","first-page":"303","volume":"7","author":"L Zhang","year":"2015","unstructured":"Zhang, L., Chen, X., Su, T., Li, H., Huang, Q., Wu, D., Yang, C., & Han, Z. (2015). Circulating miR-499 are novel and sensitive biomarker of acute myocardial infarction. Journal of Thoracic Disease, 7, 303\u2013308.","journal-title":"Journal of Thoracic Disease"},{"key":"9661_CR5","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.ijbiomac.2017.01.074","volume":"97","author":"M Raish","year":"2017","unstructured":"Raish, M. (2017). Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-kappaB signaling pathway. International Journal of Biological Macromolecules, 97, 544\u2013551.","journal-title":"International Journal of Biological Macromolecules"},{"issue":"9","key":"9661_CR6","doi-asserted-by":"publisher","first-page":"e008024","DOI":"10.1161\/JAHA.117.008024","volume":"7","author":"X Wang","year":"2018","unstructured":"Wang, X., Guo, Z., Ding, Z., & Mehta, J. L. (2018). Inflammation, autophagy, and apoptosis after myocardial infarction. Journal of the American Heart Association, 7(9), e008024.","journal-title":"Journal of the American Heart Association"},{"key":"9661_CR7","doi-asserted-by":"publisher","first-page":"e244","DOI":"10.1038\/cddis.2011.130","volume":"2","author":"M Chiong","year":"2011","unstructured":"Chiong, M., Wang, Z. V., Pedrozo, Z., Cao, D. J., Troncoso, R., Ibacache, M., Criollo, A., Nemchenko, A., Hill, J. A., & Lavandero, S. (2011). Cardiomyocyte death: Mechanisms and translational implications. Cell Death and Disease, 2, e244.","journal-title":"Cell Death and Disease"},{"key":"9661_CR8","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.aanat.2012.07.013","volume":"195","author":"S Sopka","year":"2013","unstructured":"Sopka, S., Mertens, C., Roehl, A. B., Schiffl, K., Rossaint, R., & Classen-Linke, I. (2013). Effects of xenon and isoflurane on apoptosis and inflammation in a porcine myocardial infarction model. Annals of Anatomy, 195, 166\u2013174.","journal-title":"Annals of Anatomy"},{"key":"9661_CR9","doi-asserted-by":"publisher","first-page":"7460","DOI":"10.1038\/s41598-017-07578-x","volume":"7","author":"C Sun","year":"2017","unstructured":"Sun, C., Liu, H., Guo, J., Yu, Y., Yang, D., He, F., & Du, Z. (2017). MicroRNA-98 negatively regulates myocardial infarction-induced apoptosis by down-regulating Fas and caspase-3. Scientific Reports, 7, 7460.","journal-title":"Scientific Reports"},{"issue":"1","key":"9661_CR10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/diagnostics11010032","volume":"11","author":"A Rocchi","year":"2020","unstructured":"Rocchi, A., Chiti, E., Maiese, A., Turillazzi, E., & Spinetti, I. (2020). MicroRNAs: An update of applications in forensic science. Diagnostics, 11(1), 32.","journal-title":"Diagnostics"},{"issue":"1","key":"9661_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/diagnostics11010064","volume":"11","author":"A Maiese","year":"2021","unstructured":"Maiese, A., Scatena, A., Costantino, A., Di Paolo, M., La Russa, R., Turillazzi, E., Frati, P., & Fineschi, V. (2021). MicroRNAs as useful tools to estimate time since death. A systematic review of current literature. Diagnostics, 11(1), 64.","journal-title":"Diagnostics"},{"key":"9661_CR12","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.1111\/jcmm.14463","volume":"23","author":"E Pinchi","year":"2019","unstructured":"Pinchi, E., Frati, P., Aromatario, M., Cipolloni, L., Fabbri, M., La Russa, R., Maiese, A., Neri, M., Santurro, A., Scopetti, M., Viola, R. V., Turillazzi, E., & Fineschi, V. (2019). miR-1, miR-499 and miR-208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction. Journal of Cellular and Molecular Medicine, 23, 6005\u20136016.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"9661_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.yjmcc.2019.11.151","volume":"138","author":"JRA Boen","year":"2020","unstructured":"Boen, J. R. A., Gevaert, A. B., De Keulenaer, G. W., Van Craenenbroeck, E. M., & Segers, V. F. M. (2020). The role of endothelial miRNAs in myocardial biology and disease. Journal of Molecular and Cellular Cardiology, 138, 75\u201387.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"9661_CR14","doi-asserted-by":"publisher","first-page":"4352450","DOI":"10.1155\/2017\/4352450","volume":"2017","author":"X Yan","year":"2017","unstructured":"Yan, X., Gan, Y., Chen, H., Liu, G., Hu, S., & Zhou, J. (2017). The miRNA expression profile in acute myocardial infarct using sheep model with left ventricular assist device unloading. BioMed Research International, 2017, 4352450.","journal-title":"BioMed Research International"},{"key":"9661_CR15","first-page":"843","volume":"21","author":"ZH Liu","year":"2017","unstructured":"Liu, Z. H., Sun, X. P., Zhou, S. L., & Wang, H. X. (2017). Research on the relations between the variation of miRNA-184 before and after treatment of acute myocardial infarction and prognosis. European Review for Medical and Pharmacological Sciences, 21, 843\u2013847.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"9661_CR16","first-page":"H206","volume":"310","author":"L Liu","year":"2016","unstructured":"Liu, L., Zang, J., Chen, X., Yang, G., Zhu, Y., Wu, Y., & Li, T. (2016). Role of miR-124 and miR-141 in the regulation of vascular reactivity and the relationship to RhoA and Rac1 after hemorrhage and hypoxia. American Journal of Physiology: Heart and Circulatory Physiology, 310, H206\u2013H216.","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"9661_CR17","doi-asserted-by":"publisher","first-page":"14382","DOI":"10.18632\/oncotarget.24205","volume":"9","author":"Y Zhao","year":"2018","unstructured":"Zhao, Y., Yan, M., Chen, C., Gong, W., Yin, Z., Li, H., Fan, J., Zhang, X. A., Wang, D. W., & Zuo, H. (2018). MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart. Oncotarget, 9, 14382\u201314396.","journal-title":"Oncotarget"},{"key":"9661_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.14715\/cmb\/2017.63.4.4","volume":"63","author":"Q Bao","year":"2017","unstructured":"Bao, Q., Chen, L., Li, J., Zhao, M., Wu, S., Wu, W., & Liu, X. (2017). Role of microRNA-124 in cardiomyocyte hypertrophy induced by angiotensin II. Cellular and Molecular Biology, 63, 23\u201327.","journal-title":"Cellular and Molecular Biology"},{"key":"9661_CR19","first-page":"1054","volume":"21","author":"ML Guo","year":"2017","unstructured":"Guo, M. L., Guo, L. L., & Weng, Y. Q. (2017). Implication of peripheral blood miRNA-124 in predicting acute myocardial infarction. European Review for Medical and Pharmacological Sciences, 21, 1054\u20131059.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"9661_CR20","first-page":"H2101","volume":"293","author":"M Wang","year":"2007","unstructured":"Wang, M., Zhang, W., Crisostomo, P., Markel, T., Meldrum, K. K., Fu, X. Y., & Meldrum, D. R. (2007). Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling. American Journal of Physiology: Heart and Circulatory Physiology, 293, H2101\u2013H2108.","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"9661_CR21","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.111.255604","volume":"109","author":"G Heusch","year":"2011","unstructured":"Heusch, G., Musiolik, J., Gedik, N., & Skyschally, A. (2011). Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia\/reperfusion. Circulation Research, 109, 1302\u20131308.","journal-title":"Circulation Research"},{"key":"9661_CR22","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","volume":"104","author":"P Krishnamurthy","year":"2009","unstructured":"Krishnamurthy, P., Rajasingh, J., Lambers, E., Qin, G., Losordo, D. W., & Kishore, R. (2009). IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circulation Research, 104, e9\u2013e18.","journal-title":"Circulation Research"},{"issue":"199","key":"9661_CR23","first-page":"208","volume":"39","author":"K Bayne","year":"1996","unstructured":"Bayne, K. (1996). Revised Guide for the Care and Use of Laboratory Animals available. Physiologist (American Physiological Society), 39(199), 208\u2013111.","journal-title":"Physiologist (American Physiological Society)"},{"key":"9661_CR24","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1093\/icvts\/ivs471","volume":"16","author":"M Munz","year":"2013","unstructured":"Munz, M., Amorim, M. J., Faria, M., Vicente, C., Pinto, A., Monteiro, J., Leite-Moreira, A. F., & Aguas, A. P. (2013). Cardiac venous arterialization in acute myocardial infarction: How great is the benefit? Interactive Cardiovascular and Thoracic Surgery, 16, 307\u2013313.","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"key":"9661_CR25","first-page":"15017117","volume":"15","author":"B Li","year":"2016","unstructured":"Li, B., Yang, M., Liu, J. W., & Yin, G. T. (2016). Protective mechanism of quercetin on acute myocardial infarction in rats. Genetics and Molecular Research, 15, 15017117.","journal-title":"Genetics and Molecular Research"},{"key":"9661_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41420-019-0161-y","volume":"5","author":"C Yang","year":"2019","unstructured":"Yang, C., Zhang, C., Jia, J., Wang, L., Zhang, W., Li, J., Xu, M., Rong, R., & Zhu, T. (2019). Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses. Cell Death Discovery, 5, 78.","journal-title":"Cell Death Discovery"},{"key":"9661_CR27","first-page":"5003","volume":"9","author":"H Xu","year":"2017","unstructured":"Xu, H., Cao, H., Zhu, G., Liu, S., & Li, H. (2017). Overexpression of microRNA-145 protects against rat myocardial infarction through targeting PDCD4. American Journal of Translational Research, 9, 5003\u20135011.","journal-title":"American Journal of Translational Research"},{"key":"9661_CR28","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1536\/ihj.15-293","volume":"57","author":"X Yang","year":"2016","unstructured":"Yang, X., Qin, Y., Shao, S., Yu, Y., Zhang, C., Dong, H., Lv, G., & Dong, S. (2016). MicroRNA-214 inhibits left ventricular remodeling in an acute myocardial infarction rat model by suppressing cellular apoptosis via the phosphatase and tensin homolog (PTEN). International Heart Journal, 57, 247\u2013250.","journal-title":"International Heart Journal"},{"key":"9661_CR29","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jacc.2014.04.068","volume":"64","author":"F Ahmad","year":"2014","unstructured":"Ahmad, F., Lal, H., Zhou, J., Vagnozzi, R. J., Yu, J. E., Shang, X., Woodgett, J. R., Gao, E., & Force, T. (2014). Cardiomyocyte-specific deletion of Gsk3alpha mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure. Journal of the American College of Cardiology, 64, 696\u2013706.","journal-title":"Journal of the American College of Cardiology"},{"key":"9661_CR30","first-page":"3403","volume":"19","author":"YL Tuo","year":"2015","unstructured":"Tuo, Y. L., Li, X. M., & Luo, J. (2015). Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143. European Review for Medical and Pharmacological Sciences, 19, 3403\u20133411.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"9661_CR31","first-page":"2070","volume":"22","author":"ML Guo","year":"2018","unstructured":"Guo, M. L., Guo, L. L., Qin, Q. J., Weng, Y. Q., Wang, Y. N., Yao, J., Wang, Y. B., Zhang, X. Z., & Ge, Z. M. (2018). The molecular mechanism of serum microRNA124b induced coronary heart disease by inducing myocardial cell senescence. European Review for Medical and Pharmacological Sciences, 22, 2070\u20132076.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"9661_CR32","first-page":"1034","volume":"42","author":"HX Jin","year":"2018","unstructured":"Jin, H. X., Zhang, Y. H., Guo, R. N., & Zhao, S. N. (2018). Inhibition of MEK\/ERK\/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia\/reperfusion. International Journal of Molecular Medicine, 42, 1034\u20131043.","journal-title":"International Journal of Molecular Medicine"},{"key":"9661_CR33","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.12659\/MSM.898722","volume":"22","author":"L Wu","year":"2016","unstructured":"Wu, L., Maimaitirexiati, X., Jiang, Y., & Liu, L. (2016). Parkin regulates mitochondrial autophagy after myocardial infarction in rats. Medical Science Monitor, 22, 1553\u20131559.","journal-title":"Medical Science Monitor"},{"key":"9661_CR34","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s10735-013-9535-2","volume":"45","author":"X Wang","year":"2014","unstructured":"Wang, X., Lv, H., Gu, Y., Wang, X., Cao, H., Tang, Y., Chen, H., & Huang, C. (2014). Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9. Journal of Molecular Histology, 45, 113\u2013120.","journal-title":"Journal of Molecular Histology"},{"key":"9661_CR35","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/echo.12500","volume":"31","author":"F Oz","year":"2014","unstructured":"Oz, F., Cizgici, A. Y., Ucar, A., Karaayvaz, E. B., Kocaaga, M., Bugra, Z., Mercanoglu, F., Oncul, A., Nisli, K., & Oflaz, H. (2014). Doppler-derived strain imaging detects left ventricular systolic dysfunction in children with Turner syndrome. Echocardiography, 31, 1017\u20131022.","journal-title":"Echocardiography"},{"key":"9661_CR36","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/echo.13453","volume":"34","author":"M Petrovic","year":"2017","unstructured":"Petrovic, M., Petrovic, M., Milasinovic, G., Vujisic Tesic, B., Trifunovic, D., Petrovic, O., Nedeljkovic, I., Petrovic, I., Banovic, M., Boricic-Kostic, M., Petrovic, J., Arena, R., & Popovic, D. (2017). Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome. Echocardiography, 34, 371\u2013375.","journal-title":"Echocardiography"},{"key":"9661_CR37","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2012.02.028","volume":"222","author":"N Carrabba","year":"2012","unstructured":"Carrabba, N., Parodi, G., Valenti, R., Migliorini, A., Bellandi, B., & Antoniucci, D. (2012). Prognostic value of reverse left ventricular remodeling after primary angioplasty for STEMI. Atherosclerosis, 222, 123\u2013128.","journal-title":"Atherosclerosis"},{"key":"9661_CR38","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.cardiores.2006.06.003","volume":"71","author":"Y Li","year":"2006","unstructured":"Li, Y., Takemura, G., Okada, H., Miyata, S., Maruyama, R., Li, L., Higuchi, M., Minatoguchi, S., Fujiwara, T., & Fujiwara, H. (2006). Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure. Cardiovascular Research, 71, 684\u2013694.","journal-title":"Cardiovascular Research"},{"key":"9661_CR39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1023\/A:1021129410221","volume":"242","author":"A Deten","year":"2003","unstructured":"Deten, A., Volz, H. C., Briest, W., & Zimmer, H. G. (2003). Differential cytokine expression in myocytes and non-myocytes after myocardial infarction in rats. Molecular and Cellular Biochemistry, 242, 47\u201355.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"9661_CR40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2353\/ajpath.2008.070974","volume":"173","author":"M Bujak","year":"2008","unstructured":"Bujak, M., Dobaczewski, M., Chatila, K., Mendoza, L. H., Li, N., Reddy, A., & Frangogiannis, N. G. (2008). Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. American Journal of Pathology, 173, 57\u201367.","journal-title":"American Journal of Pathology"},{"issue":"1","key":"9661_CR41","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3390\/ijms22010321","volume":"22","author":"AC Manetti","year":"2020","unstructured":"Manetti, A. C., Maiese, A., Paolo, M. D., De Matteis, A., La Russa, R., Turillazzi, E., Frati, P., & Fineschi, V. (2020). MicroRNAs and sepsis-induced cardiac dysfunction: A systematic review. International Journal of Molecular Sciences, 22(1), 321.","journal-title":"International Journal of Molecular Sciences"},{"key":"9661_CR42","doi-asserted-by":"publisher","first-page":"12929","DOI":"10.1073\/pnas.2134694100","volume":"100","author":"JJ Jacoby","year":"2003","unstructured":"Jacoby, J. J., Kalinowski, A., Liu, M. G., Zhang, S. S., Gao, Q., Chai, G. X., Ji, L., Iwamoto, Y., Li, E., Schneider, M., Russell, K. S., & Fu, X. Y. (2003). Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proceedings of the National Academy of Sciences of USA, 100, 12929\u201312934.","journal-title":"Proceedings of the National Academy of Sciences of USA"},{"key":"9661_CR43","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1093\/bfgp\/elt028","volume":"12","author":"AP Hutchins","year":"2013","unstructured":"Hutchins, A. P., Diez, D., & Miranda-Saavedra, D. (2013). The IL-10\/STAT3-mediated anti-inflammatory response: Recent developments and future challenges. Briefings in Functional Genomics, 12, 489\u2013498.","journal-title":"Briefings in Functional Genomics"},{"key":"9661_CR44","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.surg.2011.05.017","volume":"150","author":"MC Manukyan","year":"2011","unstructured":"Manukyan, M. C., Alvernaz, C. H., Poynter, J. A., Wang, Y., Brewster, B. D., Weil, B. R., Abarbanell, A. M., Herrmann, J. L., Crowe, B. J., Keck, A. C., & Meldrum, D. R. (2011). Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. Surgery, 150, 231\u2013239.","journal-title":"Surgery"},{"key":"9661_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2015.11.017","volume":"90","author":"O Chen","year":"2016","unstructured":"Chen, O., Ye, Z., Cao, Z., Manaenko, A., Ning, K., Zhai, X., Zhang, R., Zhang, T., Chen, X., Liu, W., & Sun, X. (2016). Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. Free Radical Biology and Medicine, 90, 1\u201311.","journal-title":"Free Radical Biology and Medicine"},{"key":"9661_CR46","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/cvr\/cvn335","volume":"81","author":"M Hori","year":"2009","unstructured":"Hori, M., & Nishida, K. (2009). Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovascular Research, 81, 457\u2013464.","journal-title":"Cardiovascular Research"},{"key":"9661_CR47","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1093\/eurheartj\/ehq522","volume":"32","author":"SD Solomon","year":"2011","unstructured":"Solomon, S. D., Shin, S. H., Shah, A., Skali, H., Desai, A., Kober, L., Maggioni, A. P., Rouleau, J. L., Kelly, R. Y., Hester, A., McMurray, J. J., Pfeffer, M. A., & Aliskiren Study in Post-MI Patients to Reduce Remodelling (ASPIRE) Investigators. (2011). Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. European Heart Journal, 32, 1227\u20131234.","journal-title":"European Heart Journal"},{"key":"9661_CR48","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s12031-013-0155-9","volume":"52","author":"F Zhu","year":"2014","unstructured":"Zhu, F., Liu, J. L., Li, J. P., Xiao, F., Zhang, Z. X., & Zhang, L. (2014). MicroRNA-124 (miR-124) regulates Ku70 expression and is correlated with neuronal death induced by ischemia\/reperfusion. Journal of Molecular Neuroscience, 52, 148\u2013155.","journal-title":"Journal of Molecular Neuroscience"},{"key":"9661_CR49","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.stem.2011.02.002","volume":"8","author":"FS Loffredo","year":"2011","unstructured":"Loffredo, F. S., Steinhauser, M. L., Gannon, J., & Lee, R. T. (2011). Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell, 8, 389\u2013398.","journal-title":"Cell Stem Cell"},{"key":"9661_CR50","doi-asserted-by":"publisher","first-page":"6940195","DOI":"10.1155\/2016\/6940195","volume":"2016","author":"G Suzuki","year":"2016","unstructured":"Suzuki, G., Young, R. F., Leiker, M. M., & Suzuki, T. (2016). Heart-derived stem cells in miniature swine with coronary microembolization: Novel ischemic cardiomyopathy model to assess the efficacy of cell-based therapy. Stem Cells International, 2016, 6940195.","journal-title":"Stem Cells International"},{"key":"9661_CR51","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T. D., Guerquin-Kern, J. L., Lechene, C. P., & Lee, R. T. (2013). Mammalian heart renewal by pre-existing cardiomyocytes. Nature, 493, 433\u2013436.","journal-title":"Nature"},{"key":"9661_CR52","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/s41586-019-1191-6","volume":"569","author":"K Gabisonia","year":"2019","unstructured":"Gabisonia, K., Prosdocimo, G., Aquaro, G. D., Carlucci, L., Zentilin, L., Secco, I., Ali, H., Braga, L., Gorgodze, N., Bernini, F., Burchielli, S., Collesi, C., Zandona, L., Sinagra, G., Piacenti, M., Zacchigna, S., Bussani, R., Recchia, F. A., & Giacca, M. (2019). MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. Nature, 569, 418\u2013422.","journal-title":"Nature"},{"key":"9661_CR53","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S0008-6363(00)00138-3","volume":"47","author":"S Negoro","year":"2000","unstructured":"Negoro, S., Kunisada, K., Tone, E., Funamoto, M., Oh, H., Kishimoto, T., & Yamauchi-Takihara, K. (2000). Activation of JAK\/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. Cardiovascular Research, 47, 797\u2013805.","journal-title":"Cardiovascular Research"},{"key":"9661_CR54","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1002\/stem.1154","volume":"30","author":"B Cai","year":"2012","unstructured":"Cai, B., Li, J., Wang, J., Luo, X., Ai, J., Liu, Y., Wang, N., Liang, H., Zhang, M., Chen, N., Wang, G., Xing, S., Zhou, X., Yang, B., Wang, X., & Lu, Y. (2012). microRNA-124 regulates cardiomyocyte differentiation of bone marrow-derived mesenchymal stem cells via targeting STAT3 signaling. Stem Cells, 30, 1746\u20131755.","journal-title":"Stem Cells"},{"key":"9661_CR55","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.biopha.2017.07.143","volume":"94","author":"J Li","year":"2017","unstructured":"Li, J., Xiang, X., Gong, X., Shi, Y., Yang, J., & Xu, Z. (2017). Cilostazol protects mice against myocardium ischemic\/reperfusion injury by activating a PPARgamma\/JAK2\/STAT3 pathway. Biomedicine and Pharmacotherapy, 94, 995\u20131001.","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"9661_CR56","doi-asserted-by":"publisher","first-page":"14192","DOI":"10.1074\/jbc.M111.323899","volume":"287","author":"OA Timofeeva","year":"2012","unstructured":"Timofeeva, O. A., Chasovskikh, S., Lonskaya, I., Tarasova, N. I., Khavrutskii, L., Tarasov, S. G., Zhang, X., Korostyshevskiy, V. R., Cheema, A., Zhang, L., Dakshanamurthy, S., Brown, M. L., & Dritschilo, A. (2012). Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA. The Journal of Biological Chemistry, 287, 14192\u201314200.","journal-title":"The Journal of Biological Chemistry"},{"key":"9661_CR57","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1006\/jmcc.2001.1456","volume":"33","author":"R Hattori","year":"2001","unstructured":"Hattori, R., Maulik, N., Otani, H., Zhu, L., Cordis, G., Engelman, R. M., Siddiqui, M. A., & Das, D. K. (2001). Role of STAT3 in ischemic preconditioning. Journal of Molecular and Cellular Cardiology, 33, 1929\u20131936.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"9661_CR58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/1423-0127-18-53","volume":"18","author":"Y Tian","year":"2011","unstructured":"Tian, Y., Zhang, W., Xia, D., Modi, P., Liang, D., & Wei, M. (2011). Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway. Journal of Biomedical Science, 18, 53.","journal-title":"Journal of Biomedical Science"},{"key":"9661_CR59","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.3892\/etm.2017.4716","volume":"14","author":"C Zhang","year":"2017","unstructured":"Zhang, C., Deng, Y., Lei, Y., Zhao, J., Wei, W., & Li, Y. (2017). Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Experimental and Therapeutic Medicine, 14, 2201\u20132205.","journal-title":"Experimental and Therapeutic Medicine"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-021-09661-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09661-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T05:21:52Z","timestamp":1675488112000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-021-09661-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["9661"],"URL":"https:\/\/doi.org\/10.1007\/s12012-021-09661-2","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"13 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This experiment was reviewed by the Ethics Committee of our hospital, and carried out in strict accordance with the commendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (NIH).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}