{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:46:37Z","timestamp":1782139597415,"version":"3.54.5"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004577","name":"Kementerian Pertanian dan Industri Asas Tani Malaysia","doi-asserted-by":"publisher","award":["304.PPSK.6150169.K123"],"award-info":[{"award-number":["304.PPSK.6150169.K123"]}],"id":[{"id":"10.13039\/501100004577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","award":["2020\/2021"],"award-info":[{"award-number":["2020\/2021"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12012-021-09666-x","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T18:02:48Z","timestamp":1623348168000},"page":"605-618","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Current Updates on Potential Role of Flavonoids in Hypoxia\/Reoxygenation Cardiac Injury Model"],"prefix":"10.1007","volume":"21","author":[{"given":"Shafreena Shaukat","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Noordin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruzilawati Abu","family":"Bakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satirah","family":"Zainalabidin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakiah","family":"Jubri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-2559","authenticated-orcid":false,"given":"Wan Amir Nizam","family":"Wan Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"9666_CR1","unstructured":"World Health Organization. (2021). Cardiovascular diseases. https:\/\/www.who.int\/health-topics\/cardiovascular-diseases"},{"key":"9666_CR2","unstructured":"Ministry of Health Malaysia. (2020). The impact of noncommunicable diseases and their risk factors on Malaysia\u2019s gross domestic product."},{"issue":"28","key":"9666_CR3","doi-asserted-by":"publisher","first-page":"11760","DOI":"10.1074\/jbc.M116.751826","volume":"292","author":"AD McDougal","year":"2017","unstructured":"McDougal, A. D., & Dewey, C. F., Jr. (2017). Modeling oxygen requirements in ischemic cardiomyocytes. Journal of Biological Chemistry, 292(28), 11760\u201311776. https:\/\/doi.org\/10.1074\/jbc.M116.751826","journal-title":"Journal of Biological Chemistry"},{"issue":"21","key":"9666_CR4","doi-asserted-by":"publisher","first-page":"8118","DOI":"10.3390\/ijms21218118","volume":"21","author":"P Severino","year":"2020","unstructured":"Severino, P., D\u2019Amato, A., Pucci, M., Infusino, F., Adamo, F., Birtolo, L. I., Netti, L., Montefusco, G., Chimenti, C., Lavalle, C., & Maestrini, V. (2020). Ischemic heart disease pathophysiology paradigms overview: From plaque activation to microvascular dysfunction. International Journal of Molecular Sciences, 21(21), 8118. https:\/\/doi.org\/10.3390\/ijms21218118","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"9666_CR5","doi-asserted-by":"publisher","first-page":"8060","DOI":"10.7326\/AITC201908060","volume":"171","author":"D Katz","year":"2019","unstructured":"Katz, D., & Gavin, M. C. (2019). Stable ischemic heart disease. Annals of Internal Medicine, 171(3), 8060.","journal-title":"Annals of Internal Medicine"},{"issue":"4","key":"9666_CR6","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1159\/000489241","volume":"46","author":"MY Wu","year":"2018","unstructured":"Wu, M. Y., Yiang, G. T., Liao, W. T., Tsai, A. P. Y., Cheng, Y. L., Cheng, P. W., Li, C. Y., & Li, C. J. (2018). Current mechanistic concepts in ischemia and reperfusion injury. Cellular Physiology and Biochemistry, 46(4), 1650\u20131667. https:\/\/doi.org\/10.1159\/000489241","journal-title":"Cellular Physiology and Biochemistry"},{"key":"9666_CR7","volume-title":"Mechanisms of vascular disease: Pathophysiology of reperfusion injury","author":"P Cowled","year":"2011","unstructured":"Cowled, P., & Fitridge, R. (2011). Mechanisms of vascular disease: Pathophysiology of reperfusion injury. Adelaide (AU): University of Adelaide Press."},{"key":"9666_CR8","doi-asserted-by":"publisher","first-page":"7018393","DOI":"10.1155\/2017\/7018393","volume":"2017","author":"M Neri","year":"2017","unstructured":"Neri, M., Riezzo, I., Pascale, N., Pomara, C., & Turillazzi, E. (2017). Ischemia\/reperfusion injury following acute myocardial infarction: A critical issue for clinicians and forensic pathologists. Mediators of Inflammation, 2017, 7018393. https:\/\/doi.org\/10.1155\/2017\/7018393","journal-title":"Mediators of Inflammation"},{"key":"9666_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8946-7","volume-title":"Modulation of oxidative stress in heart disease","author":"S Chakraborti","year":"2019","unstructured":"Chakraborti, S., Dhalla, N. S., Dikshit, M., & Ganguly, N. K. (2019). Modulation of oxidative stress in heart disease. Singapore: Springer."},{"issue":"4","key":"9666_CR10","doi-asserted-by":"publisher","first-page":"H812","DOI":"10.1152\/ajpheart.00335.2017","volume":"314","author":"ML Lindsey","year":"2018","unstructured":"Lindsey, M. L., Bolli, R., Canty, J. M., Jr., Du, X. J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., & Lefer, D. J. (2018). Guidelines for experimental models of myocardial ischemia and infarction. American Journal of Physiology, 314(4), H812\u2013H838. https:\/\/doi.org\/10.1152\/ajpheart.00335.2017","journal-title":"American Journal of Physiology"},{"issue":"6","key":"9666_CR11","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1097\/HCO.0000000000000447","volume":"32","author":"M Donato","year":"2017","unstructured":"Donato, M., Evelson, P., & Gelpi, R. J. (2017). Protecting the heart from ischemia\/reperfusion injury: An update on remote ischemic preconditioning and postconditioning. Current Opinion in Cardiology, 32(6), 784\u2013790. https:\/\/doi.org\/10.1097\/HCO.0000000000000447","journal-title":"Current Opinion in Cardiology"},{"issue":"8","key":"9666_CR12","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.18632\/aging.101527","volume":"10","author":"JD Da Zhou","year":"2018","unstructured":"Da Zhou, J. D., Ya, J., Pan, L., Wang, Y., Ji, X., & Meng, R. (2018). Remote ischemic conditioning: A promising therapeutic intervention for multi-organ protection. Aging, 10(8), 1825. https:\/\/doi.org\/10.18632\/aging.101527","journal-title":"Aging"},{"key":"9666_CR13","doi-asserted-by":"publisher","first-page":"5939715","DOI":"10.1155\/2020\/5939715","volume":"2020","author":"H Jiang","year":"2020","unstructured":"Jiang, H., Xing, J., Fang, J., Wang, L., Wang, Y., Zeng, L., Li, Z., & Liu, R. (2020). Tilianin Protects against ischemia\/reperfusion-induced myocardial injury through the inhibition of the Ca2+\/calmodulin-dependent protein kinase II-dependent apoptotic and inflammatory signalling pathways. BioMed Research International, 2020, 5939715. https:\/\/doi.org\/10.1155\/2020\/5939715","journal-title":"BioMed Research International"},{"issue":"2","key":"9666_CR14","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.bbrc.2020.07.047","volume":"531","author":"G Liu","year":"2020","unstructured":"Liu, G., Zhang, B. F., Hu, Q., Liu, X. P., & Chen, J. (2020). Syringic acid mitigates myocardial ischemia reperfusion injury by activating the PI3K\/Akt\/GSK-3\u03b2 signalling pathway. Biochemical and Biophysical Research Communications, 531(2), 242\u2013249. https:\/\/doi.org\/10.1016\/j.bbrc.2020.07.047","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9666_CR15","doi-asserted-by":"publisher","first-page":"8348035","DOI":"10.1155\/2020\/8348035","volume":"2020","author":"X Yao","year":"2020","unstructured":"Yao, X., Jiao, S., Qin, M., Hu, W., Yi, B., & Liu, D. (2020). Vanillic acid alleviates acute myocardial hypoxia\/reoxygenation injury by inhibiting oxidative stress. Oxidative Medicine and. Cellular Longevity, 2020, 8348035. https:\/\/doi.org\/10.1155\/2020\/8348035","journal-title":"Oxidative Medicine and. Cellular Longevity"},{"issue":"5","key":"9666_CR16","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.3892\/ijmm.2019.4131","volume":"43","author":"M Wang","year":"2019","unstructured":"Wang, M., Liu, Y., Pan, R. L., Wang, R. Y., Ding, S. L., Dong, W. R., Sun, G. B., Ye, J. X., & Sun, X. B. (2019). Protective effects of Myrica rubra flavonoids against hypoxia\/reoxygenation-induced cardiomyocyte injury via the regulation of the PI3K\/Akt\/GSK3\u03b2 pathway. International Journal of Molecular Medicine, 43(5), 2133\u20132143. https:\/\/doi.org\/10.3892\/ijmm.2019.4131","journal-title":"International Journal of Molecular Medicine"},{"issue":"5","key":"9666_CR17","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1248\/bpb.b18-00854","volume":"42","author":"P Yang","year":"2019","unstructured":"Yang, P., Zhou, Y., Xia, Q., Yao, L., & Chang, X. (2019). Astragaloside IV regulates the PI3K\/Akt\/HO-1 signalling pathway and inhibits H9c2 cardiomyocyte injury induced by hypoxia\u2013reoxygenation. Biological and Pharmaceutical Bulletin, 42(5), 721\u2013727. https:\/\/doi.org\/10.1248\/bpb.b18-00854","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"9666_CR18","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fphar.2018.00497","volume":"9","author":"WY Wu","year":"2018","unstructured":"Wu, W. Y., Li, Y. D., Cui, Y. K., Wu, C., Hong, Y. X., Li, G., Wu, Y., Jie, L. J., Wang, Y., & Li, G. R. (2018). The natural flavone acacetin confers cardiomyocyte protection against hypoxia\/reoxygenation injury via AMPK-mediated activation of Nrf2 signalling pathway. Frontiers in Pharmacology, 9, 497. https:\/\/doi.org\/10.3389\/fphar.2018.00497","journal-title":"Frontiers in Pharmacology"},{"key":"9666_CR19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.phymed.2018.01.004","volume":"40","author":"HJ Zhang","year":"2018","unstructured":"Zhang, H. J., Chen, R. C., Sun, G. B., Yang, L. P., Xu, X. D., & Sun, X. B. (2018). Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt\/Nrf2\/HO-1 pathway. Phytomedicine, 40, 88\u201397. https:\/\/doi.org\/10.1016\/j.phymed.2018.01.004","journal-title":"Phytomedicine"},{"issue":"2","key":"9666_CR20","doi-asserted-by":"publisher","first-page":"225","DOI":"10.31083\/j.rcm.2020.02.49","volume":"21","author":"SS Ali","year":"2020","unstructured":"Ali, S. S., Ahmad, W. A. N. W., Budin, S. B., & Zainalabidin, S. (2020). Implication of dietary phenolic acids on inflammation in cardiovascular disease. Reviews in Cardiovascular Medicine, 21(2), 225\u2013240. https:\/\/doi.org\/10.31083\/j.rcm.2020.02.49","journal-title":"Reviews in Cardiovascular Medicine"},{"key":"9666_CR21","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1146\/annurev-nutr-071715-050718","volume":"36","author":"EE Mulvihill","year":"2016","unstructured":"Mulvihill, E. E., Burke, A. C., & Huff, M. W. (2016). Citrus flavonoids as regulators of lipoprotein metabolism and atherosclerosis. Annual Review of Nutrition, 36, 275\u2013299. https:\/\/doi.org\/10.1146\/annurev-nutr-071715-050718","journal-title":"Annual Review of Nutrition"},{"issue":"2","key":"9666_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3390\/molecules22020209","volume":"22","author":"Y Marunaka","year":"2017","unstructured":"Marunaka, Y., Marunaka, R., Sun, H., Yamamoto, T., Kanamura, N., Inui, T., & Taruno, A. (2017). Actions of quercetin, a polyphenol, on blood pressure. Molecules, 22(2), 209. https:\/\/doi.org\/10.3390\/molecules22020209","journal-title":"Molecules"},{"key":"9666_CR23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.jep.2017.08.035","volume":"210","author":"QY Eng","year":"2018","unstructured":"Eng, Q. Y., Thanikachalam, P. V., & Ramamurthy, S. (2018). Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases. Journal of Ethnopharmacology, 210, 296\u2013310. https:\/\/doi.org\/10.1016\/j.jep.2017.08.035","journal-title":"Journal of Ethnopharmacology"},{"key":"9666_CR24","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3389\/fphar.2019.01295","volume":"10","author":"KW Choy","year":"2019","unstructured":"Choy, K. W., Murugan, D., Leong, X. F., Abas, R., Alias, A., & Mustafa, M. R. (2019). Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NF\u03baB) signalling in cardiovascular diseases: A mini review. Frontiers in Pharmacology, 10, 1295. https:\/\/doi.org\/10.3389\/fphar.2019.01295","journal-title":"Frontiers in Pharmacology"},{"issue":"18","key":"9666_CR25","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.3390\/molecules25184320","volume":"25","author":"L Cium\u0103rnean","year":"2020","unstructured":"Cium\u0103rnean, L., Milaciu, M. V., Runcan, O., Vesa, \u0218C., R\u0103chi\u0219an, A. L., Negrean, V., Pern\u00e9, M. G., Donca, V. I., Alexescu, T. G., Para, I., & Dogaru, G. (2020). The effects of flavonoids in cardiovascular diseases. Molecules, 25(18), 4320. https:\/\/doi.org\/10.3390\/molecules25184320","journal-title":"Molecules"},{"issue":"1","key":"9666_CR26","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/med.21740","volume":"41","author":"AT Rufino","year":"2021","unstructured":"Rufino, A. T., Costa, V. M., Carvalho, F., & Fernandes, E. (2021). Flavonoids as antiobesity agents: A review. Medicinal Research Reviews, 41(1), 556\u2013585. https:\/\/doi.org\/10.1002\/med.21740","journal-title":"Medicinal Research Reviews"},{"issue":"2","key":"9666_CR27","doi-asserted-by":"publisher","first-page":"173","DOI":"10.4196\/kjpp.2020.24.2.173","volume":"24","author":"E Son","year":"2020","unstructured":"Son, E., Lee, D., Woo, C. W., & Kim, Y. H. (2020). The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts. Korean Journal of Physiology Pharmacology, 24(2), 173. https:\/\/doi.org\/10.4196\/kjpp.2020.24.2.173","journal-title":"Korean Journal of Physiology Pharmacology"},{"key":"9666_CR28","first-page":"65339","volume":"47","author":"D Ger\u0151","year":"2017","unstructured":"Ger\u0151, D. (2017). Hypoxia and human diseases: The hypoxia-reoxygenation injury model. Intech Open, 47, 65339.","journal-title":"Intech Open"},{"issue":"2","key":"9666_CR29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.bbamcr.2014.11.015","volume":"1853","author":"AV Kuznetsov","year":"2015","unstructured":"Kuznetsov, A. V., Javadov, S., Sickinger, S., Frotschnig, S., & Grimm, M. (2015). H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation. Biochimica et Biophysica Acta, Molecular Cell Research, 1853(2), 276\u2013284. https:\/\/doi.org\/10.1016\/j.bbamcr.2014.11.015","journal-title":"Biochimica et Biophysica Acta, Molecular Cell Research"},{"key":"9666_CR30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fendo.2020.00057","volume":"11","author":"J Pavlacky","year":"2020","unstructured":"Pavlacky, J., & Polak, J. (2020). Technical feasibility and physiological relevance of hypoxic cell culture models. Frontiers in Endocrinology, 11, 57. https:\/\/doi.org\/10.3389\/fendo.2020.00057","journal-title":"Frontiers in Endocrinology"},{"issue":"2","key":"9666_CR31","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2217\/nnm-2019-0363","volume":"15","author":"N Sayed","year":"2020","unstructured":"Sayed, N., Tambe, P., Kumar, P., Jadhav, S., Paknikar, K. M., & Gajbhiye, V. (2020). miRNA transfection via poly (amidoamine)-based delivery vector prevents hypoxia\/reperfusion-induced cardiomyocyte apoptosis. Nanomedicine, 15(2), 163\u2013181. https:\/\/doi.org\/10.2217\/nnm-2019-0363","journal-title":"Nanomedicine"},{"key":"9666_CR32","doi-asserted-by":"publisher","first-page":"3237253","DOI":"10.1155\/2018\/3237253","volume":"2018","author":"G Teti","year":"2018","unstructured":"Teti, G., Focaroli, S., Salvatore, V., Mazzotti, E., Ingra, L., Mazzotti, A., & Falconi, M. (2018). (2018) The hypoxia-mimetic agent cobalt chloride differently affects human mesenchymal stem cells in their chondrogenic potential. Stem Cells International, 2018, 3237253. https:\/\/doi.org\/10.1155\/2018\/3237253","journal-title":"Stem Cells International"},{"key":"9666_CR33","first-page":"68","volume":"70","author":"R\u00c1 Jennings","year":"1960","unstructured":"Jennings, R. \u00c1. (1960). Myocardial necrosis induced by temporary occulusion of a coronary artery in the dog. Archives of Pathology, 70, 68\u201370.","journal-title":"Archives of Pathology"},{"key":"9666_CR34","volume-title":"Modulation of oxidative stress in heart disease: basic mechanisms of ischemia\/reperfusion injury leading to cellular and tissue damage: Therapeutic implications","author":"EE Douzinas","year":"2019","unstructured":"Douzinas, E. E., & Apeiranthitis, A. (2019). Modulation of oxidative stress in heart disease: basic mechanisms of ischemia\/reperfusion injury leading to cellular and tissue damage: Therapeutic implications. Singapore: Springer."},{"issue":"11","key":"9666_CR35","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/nm.2507","volume":"17","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig, H. K., & Eckle, T. (2011). Ischemia and reperfusion\u2014from mechanism to translation. Nature Medicine, 17(11), 1391\u20131401. https:\/\/doi.org\/10.1038\/nm.2507","journal-title":"Nature Medicine"},{"key":"9666_CR36","doi-asserted-by":"publisher","unstructured":"Frank, A., Bonney, M., Bonney, S., Weitzel, L., Koeppen, M., & Eckle, T. (2012) Myocardial ischemia-reperfusion injury: From basic science to clinical bedside. Seminars in Cardiothoracic and Vascular Anesthesia, 16(3), 123\u2013132. https:\/\/doi.org\/10.1177\/1089253211436350","DOI":"10.1177\/1089253211436350"},{"issue":"4","key":"9666_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.4103\/tcmj.tcmj_33_18","volume":"30","author":"CF Yang","year":"2018","unstructured":"Yang, C. F. (2018). Clinical manifestations and basic mechanisms of myocardial ischemia\/reperfusion injury. Tzu-Chi Med. J., 30(4), 209. https:\/\/doi.org\/10.4103\/tcmj.tcmj_33_18","journal-title":"Tzu-Chi Med. J."},{"key":"9666_CR38","doi-asserted-by":"publisher","first-page":"1656450","DOI":"10.1155\/2016\/1656450","volume":"2016","author":"GA Kurian","year":"2016","unstructured":"Kurian, G. A., Rajagopal, R., Vedantham, S., & Rajesh, M. (2016). The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited. Oxidative Medicine and Cellular Longevity, 2016, 1656450. https:\/\/doi.org\/10.1155\/2016\/1656450","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"17","key":"9666_CR39","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.3390\/ijms21176043","volume":"21","author":"FF Jubaidi","year":"2020","unstructured":"Jubaidi, F. F., Zainalabidin, S., Mariappan, V., & Budin, S. B. (2020). Mitochondrial dysfunction in diabetic cardiomyopathy: The possible therapeutic roles of phenolic acids. International Journal of Molecular Sciences, 21(17), 6043. https:\/\/doi.org\/10.3390\/ijms21176043","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"9666_CR40","doi-asserted-by":"publisher","first-page":"417","DOI":"10.5935\/1678-9741.20150052","volume":"30","author":"AEMS\u00c1S Dias","year":"2015","unstructured":"Dias, A. E. M. S. \u00c1. S., Melnikov, P., & C\u00f4nsolo, L. Z. Z. (2015). Oxidative stress in coronary artery bypass surgery. Brazilian Journal of Cardiovascular Surgery, 30(4), 417\u2013424. https:\/\/doi.org\/10.5935\/1678-9741.20150052","journal-title":"Brazilian Journal of Cardiovascular Surgery"},{"issue":"5","key":"9666_CR41","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3109\/10715762.2013.780286","volume":"47","author":"J Liu","year":"2013","unstructured":"Liu, J., Hou, J., Xia, Z. Y., Zeng, W., Wang, X., Li, R., Ke, C., Xu, J., Lei, S., & Xia, Z. (2013). Recombinant PTD-Cu\/Zn SOD attenuates hypoxia\u2013reoxygenation injury in cardiomyocytes. Free Rad. Res., 47(5), 386\u2013393. https:\/\/doi.org\/10.3109\/10715762.2013.780286","journal-title":"Free Rad. Res."},{"key":"9666_CR42","doi-asserted-by":"publisher","first-page":"5470457","DOI":"10.1155\/2016\/5470457","volume":"2016","author":"H Pei","year":"2016","unstructured":"Pei, H., Yang, Y., Zhao, H., Li, X., Yang, D., Li, D., & Yang, Y. (2016). The role of mitochondrial functional proteins in ROS production in ischemic heart diseases. Oxidative Medicine and Cellular Longevity, 2016, 5470457. https:\/\/doi.org\/10.1155\/2016\/5470457","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"9666_CR43","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","volume":"123","author":"DJ Hausenloy","year":"2013","unstructured":"Hausenloy, D. J., & Yellon, D. M. (2013). Myocardial ischemia-reperfusion injury: A neglected therapeutic target. The Journal of Clinical Investigation, 123(1), 92\u2013100. https:\/\/doi.org\/10.1172\/JCI62874","journal-title":"The Journal of Clinical Investigation"},{"issue":"5","key":"9666_CR44","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1039\/C9TX00143C","volume":"8","author":"T Barkhade","year":"2019","unstructured":"Barkhade, T., Mahapatra, S. K., & Banerjee, I. (2019). Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporation. Toxicology Research, 8(5), 711\u2013722. https:\/\/doi.org\/10.1039\/C9TX00143C","journal-title":"Toxicology Research"},{"issue":"1","key":"9666_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-019-0451-9","volume":"17","author":"CX Zhang","year":"2019","unstructured":"Zhang, C. X., Cheng, Y., Liu, D. Z., Liu, M., Cui, H., Mei, Q. B., & Zhou, S. Y. (2019). Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats. Journal of Nanobiotechnology, 17(1), 1\u201316. https:\/\/doi.org\/10.1186\/s12951-019-0451-9","journal-title":"Journal of Nanobiotechnology"},{"issue":"1","key":"9666_CR46","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/pharmaceutics13010091","volume":"13","author":"A Gendron","year":"2021","unstructured":"Gendron, A., Lan, L., Tran, N., Laloy, J., Brusini, R., Rachet, A., Gobeaux, F., Nicolas, V., Chaminade, P., Abreu, S., Desma\u00eble, D., & Varna, M. (2021). New nanoparticle formulation for cyclosporin A: In vitro assessment. Pharmaceutics, 13(1), 91. https:\/\/doi.org\/10.3390\/pharmaceutics13010091","journal-title":"Pharmaceutics"},{"issue":"9","key":"9666_CR47","doi-asserted-by":"publisher","first-page":"74","DOI":"10.4330\/wjc.v10.i9.74","volume":"10","author":"J Gonz\u00e1lez-Montero","year":"2018","unstructured":"Gonz\u00e1lez-Montero, J., Brito, R., Gajardo, A. I., & Rodrigo, R. (2018). Myocardial reperfusion injury and oxidative stress: Therapeutic opportunities. World Journal of Cardiology, 10(9), 74. https:\/\/doi.org\/10.4330\/wjc.v10.i9.74","journal-title":"World Journal of Cardiology"},{"key":"9666_CR48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.yrtph.2017.11.005","volume":"92","author":"X He","year":"2018","unstructured":"He, X., Li, S., Fang, X., & Liao, Y. (2018). TDCPP protects cardiomyocytes from hypoxia-reoxygenation injury induced apoptosis through mitigating calcium overload and promotion GSK-3\u03b2 phosphorylation. Regulatory Toxicology and Pharmacology, 92, 39\u201345. https:\/\/doi.org\/10.1016\/j.yrtph.2017.11.005","journal-title":"Regulatory Toxicology and Pharmacology"},{"issue":"12","key":"9666_CR49","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1161\/CIRCRESAHA.117.310083","volume":"120","author":"AP Landstrom","year":"2017","unstructured":"Landstrom, A. P., Dobrev, D., & Wehrens, X. H. (2017). Calcium signalling and cardiac arrhythmias. Circulation Research, 120(12), 1969\u20131993. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.310083","journal-title":"Circulation Research"},{"issue":"34","key":"9666_CR50","doi-asserted-by":"publisher","first-page":"4077","DOI":"10.2174\/1381612825666181120155953","volume":"24","author":"K Pittas","year":"2018","unstructured":"Pittas, K., Vrachatis, D. A., Angelidis, C., Tsoucala, S., Giannopoulos, G., & Deftereos, S. (2018). The role of calcium handling mechanisms in reperfusion injury. Current Pharmaceutical Design, 24(34), 4077\u20134089. https:\/\/doi.org\/10.2174\/1381612825666181120155953","journal-title":"Current Pharmaceutical Design"},{"issue":"2","key":"9666_CR51","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1093\/cvr\/cvs116","volume":"94","author":"D Garcia-Dorado","year":"2012","unstructured":"Garcia-Dorado, D., Ruiz-Meana, M., Inserte, J., Rodriguez-Sinovas, A., & Piper, H. M. (2012). Calcium-mediated cell death during myocardial reperfusion. Cardiovascular Research, 94(2), 168\u2013180. https:\/\/doi.org\/10.1093\/cvr\/cvs116","journal-title":"Cardiovascular Research"},{"key":"9666_CR52","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","volume":"298","author":"T Kalogeris","year":"2012","unstructured":"Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2012). Cell biology of ischemia\/reperfusion injury. International Review of Cell and Molecular Biology, 298, 229\u2013317. https:\/\/doi.org\/10.1016\/B978-0-12-394309-5.00006-7","journal-title":"International Review of Cell and Molecular Biology"},{"issue":"5","key":"9666_CR53","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41440-019-0391-7","volume":"43","author":"H Minato","year":"2020","unstructured":"Minato, H., Hisatome, I., Kurata, Y., Notsu, T., Nakasone, N., Ninomiya, H., Hamada, T., Tomomori, T., Okamura, A., Miake, J., & Tsuneto, M. (2020). Pretreatment with cilnidipine attenuates hypoxia\/reoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening. Hyperten. Res., 43(5), 380\u2013388. https:\/\/doi.org\/10.1038\/s41440-019-0391-7","journal-title":"Hyperten. Res."},{"key":"9666_CR54","doi-asserted-by":"publisher","first-page":"548413","DOI":"10.1155\/2019\/5484138","volume":"2019","author":"AM Mahmoud","year":"2019","unstructured":"Mahmoud, A. M., Hernandez Bautista, R. J., Sandhu, M. A., & Hussein, O. E. (2019). Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxidative Medicine and Cellular Longevity, 2019, 548413. https:\/\/doi.org\/10.1155\/2019\/5484138","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"9","key":"9666_CR55","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1080\/10408398.2015.1032400","volume":"57","author":"J Xiao","year":"2017","unstructured":"Xiao, J. (2017). Dietary flavonoid aglycones and their glycosides: Which show better biological significance? Critical Reviews in Food Science and Nutrition, 57(9), 1874\u20131905. https:\/\/doi.org\/10.1080\/10408398.2015.1032400","journal-title":"Critical Reviews in Food Science and Nutrition"},{"issue":"8","key":"9666_CR56","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1080\/10942912.2016.1220393","volume":"20","author":"M Abbas","year":"2017","unstructured":"Abbas, M., Saeed, F., Anjum, F. M., Afzaal, M., Tufail, T., Bashir, M. S., Ishtiaq, A., Hussain, S., & Suleria, H. A. R. (2017). Natural polyphenols: An overview. International Journal of Food Properties, 20(8), 1689\u20131699. https:\/\/doi.org\/10.1080\/10942912.2016.1220393","journal-title":"International Journal of Food Properties"},{"issue":"6","key":"9666_CR57","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.mam.2010.09.007","volume":"31","author":"A Crozier","year":"2010","unstructured":"Crozier, A., Del Rio, D., & Clifford, M. N. (2010). Bioavailability of dietary flavonoids and phenolic compounds. Molecular Aspects of Medicine, 31(6), 446\u2013467. https:\/\/doi.org\/10.1016\/j.mam.2010.09.007","journal-title":"Molecular Aspects of Medicine"},{"issue":"4","key":"9666_CR58","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1080\/09168451.2018.1444467","volume":"82","author":"K Murota","year":"2018","unstructured":"Murota, K., Nakamura, Y., & Uehara, M. (2018). Flavonoid metabolism: The interaction of metabolites and gut microbiota. Bioscience Biotechnology Biochemistry, 82(4), 600\u2013610. https:\/\/doi.org\/10.1080\/09168451.2018.1444467","journal-title":"Bioscience Biotechnology Biochemistry"},{"key":"9666_CR59","doi-asserted-by":"publisher","first-page":"118642","DOI":"10.1016\/j.ijpharm.2019.118642","volume":"570","author":"J Zhao","year":"2019","unstructured":"Zhao, J., Yang, J., & Xie, Y. (2019). Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview. International Journal of Pharmaceutics, 570, 118642. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118642","journal-title":"International Journal of Pharmaceutics"},{"issue":"3","key":"9666_CR60","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3945\/an.116.012948","volume":"8","author":"GL Hostetler","year":"2017","unstructured":"Hostetler, G. L., Ralston, R. A., & Schwartz, S. J. (2017). Flavones: Food sources, bioavailability, metabolism, and bioactivity. Advances in Nutrition, 8(3), 423\u2013435. https:\/\/doi.org\/10.3945\/an.116.012948","journal-title":"Advances in Nutrition"},{"key":"9666_CR61","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.biopha.2016.05.026","volume":"82","author":"Z Qiao","year":"2016","unstructured":"Qiao, Z., Xu, Y. W., & Yang, J. (2016). Eupatilin inhibits the apoptosis in H9c2 cardiomyocytes via the Akt\/GSK-3\u03b2 pathway following hypoxia\/reoxygenation injury. Biomedicine Pharmatherapy, 82, 373\u2013378. https:\/\/doi.org\/10.1016\/j.biopha.2016.05.026","journal-title":"Biomedicine Pharmatherapy"},{"issue":"3","key":"9666_CR62","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3390\/cancers12030532","volume":"12","author":"F Gallyas Jr","year":"2020","unstructured":"Gallyas, F., Jr., Sumegi, B., & Szabo, C. (2020). Role of Akt activation in PARP inhibitor resistance in cancer. Cancers, 12(3), 532. https:\/\/doi.org\/10.3390\/cancers12030532","journal-title":"Cancers"},{"issue":"1\u20132","key":"9666_CR63","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11010-016-2848-1","volume":"424","author":"JY Tang","year":"2017","unstructured":"Tang, J. Y., Jin, P., He, Q., Lu, L. H., Ma, J. P., Gao, W. L., Bai, H. P., & Yang, J. (2017). Naringenin ameliorates hypoxia\/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: Involvement in ATF6, IRE1\u03b1 and PERK signalling activation. Molecular and Cellular Biochemistry, 424(1\u20132), 111\u2013122. https:\/\/doi.org\/10.1007\/s11010-016-2848-1","journal-title":"Molecular and Cellular Biochemistry"},{"key":"9666_CR64","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ejphar.2016.02.037","volume":"776","author":"L Liu","year":"2016","unstructured":"Liu, L., Wu, Y., & Huang, X. (2016). Orientin protects myocardial cells against hypoxia-reoxygenation injury through induction of autophagy. European Journal of Pharmacology, 776, 90\u201398. https:\/\/doi.org\/10.1016\/j.ejphar.2016.02.037","journal-title":"European Journal of Pharmacology"},{"key":"9666_CR65","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3389\/fphar.2018.00497","volume":"9","author":"WY Wu","year":"2019","unstructured":"Wu, W. Y., Li, Y. D., Cui, Y. K., Wu, C., Hong, Y. X., Li, G., Wu, Y., Jie, L. J., Wang, Y., & Li, G. R. (2019). The natural flavone acacetin confers cardiomyocyte protection against hypoxia\/reoxygenation injury via AMPK-mediated activation of Nrf2 signalling pathway. Frontiers in Pharmacology, 9, 497. https:\/\/doi.org\/10.3389\/fphar.2018.00497","journal-title":"Frontiers in Pharmacology"},{"issue":"6","key":"9666_CR66","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/978-981-13-6260-6_6","volume":"67","author":"JJ Pang","year":"2015","unstructured":"Pang, J. J., Barton, L. A., Chen, Y. G., & Ren, J. (2015). Mitochondrial aldehyde dehydrogenase in myocardial ischemia-reperfusion injury: From bench to bedside. Acta Physcologica Sinica, 67(6), 535\u2013544. https:\/\/doi.org\/10.1007\/978-981-13-6260-6_6","journal-title":"Acta Physcologica Sinica"},{"issue":"3","key":"9666_CR67","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/1440-1681.12876","volume":"45","author":"WB Jiang","year":"2018","unstructured":"Jiang, W. B., Zhao, W., Chen, H., Wu, Y. Y., Wang, Y., Fu, G. S., & Yang, X. J. (2018). Baicalin protects H9c2 cardiomyocytes against hypoxia\/reoxygenation-induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2. Clinical and Experimental Pharmacology and Physiology, 45(3), 303\u2013311. https:\/\/doi.org\/10.1111\/1440-1681.12876","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"issue":"1","key":"9666_CR68","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/FJC.0000000000000587","volume":"72","author":"Y Wang","year":"2018","unstructured":"Wang, Y., Wang, Y., Wang, X., & Hu, P. (2018). Tilianin-loaded reactive oxygen species-scavenging nano-micelles protect H9c2 cardiomyocyte against hypoxia\/reoxygenation-induced injury. Journal of Cardiovascular Pharmacology, 72(1), 32\u201339. https:\/\/doi.org\/10.1097\/FJC.0000000000000587","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"5","key":"9666_CR69","doi-asserted-by":"publisher","first-page":"7156","DOI":"10.3892\/mmr.2018.8774","volume":"17","author":"S Chen","year":"2018","unstructured":"Chen, S., Yang, B., Xu, Y., Rong, Y., & Qiu, Y. (2018). Protection of Luteolin-7-O-glucoside against apoptosis induced by hypoxia\/reoxygenation through the MAPK pathways in H9c2 cells. Molecular Medicine Reports, 17(5), 7156\u20137162. https:\/\/doi.org\/10.3892\/mmr.2018.8774","journal-title":"Molecular Medicine Reports"},{"issue":"6","key":"9666_CR70","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1002\/ptr.6053","volume":"32","author":"Z Liu","year":"2018","unstructured":"Liu, Z., Yang, L., Huang, J., Xu, P., Zhang, Z., Yin, D., Liu, J., He, H., & He, M. (2018). Luteoloside attenuates anoxia\/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14\u20133-3\u03b7 protein. Phytotherapy Research, 32(6), 1126\u20131134. https:\/\/doi.org\/10.1002\/ptr.6053","journal-title":"Phytotherapy Research"},{"key":"9666_CR71","doi-asserted-by":"publisher","first-page":"109849","DOI":"10.1016\/j.biopha.2020.109849","volume":"124","author":"W Xue","year":"2020","unstructured":"Xue, W., Wang, X., Tang, H., Sun, F., Zhu, H., Huang, D., & Dong, L. (2020). Vitexin attenuates myocardial ischemia\/reperfusion injury in rats by regulating mitochondrial dysfunction induced by mitochondrial dynamics imbalance. Biomedicine & Pharmacotherapy, 124, 109849. https:\/\/doi.org\/10.1016\/j.biopha.2020.109849","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"2","key":"9666_CR72","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/cvr\/cvm029","volume":"77","author":"V Parra","year":"2018","unstructured":"Parra, V., Eisner, V., Chiong, M., Criollo, A., Moraga, F., Garcia, A., H\u00e4rtel, S., Jaimovich, E., Zorzano, A., Hidalgo, C., & Lavandero, S. (2018). Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovascular Research, 77(2), 387\u2013397. https:\/\/doi.org\/10.1093\/cvr\/cvm029","journal-title":"Cardiovascular Research"},{"key":"9666_CR73","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.84705","author":"M Herrero","year":"2012","unstructured":"Herrero, M., Plaza, M., Cifuentes, A., & Ib\u00e1\u00f1ez, E. (2012). Extraction techniques for the determination of phenolic compounds in food. Intech Open. https:\/\/doi.org\/10.5772\/intechopen.84705","journal-title":"Intech Open"},{"issue":"6","key":"9666_CR74","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/FJC.0000000000000376","volume":"67","author":"L Huang","year":"2016","unstructured":"Huang, L., He, H., Liu, Z., Liu, D., Yin, D., & He, M. (2016). Protective effects of isorhamnetin on cardiomyocytes against anoxia\/reoxygenation-induced injury is mediated by SIRT1. Journal of Cardiovascular Pharmacology, 67(6), 526\u2013537. https:\/\/doi.org\/10.1097\/FJC.0000000000000376","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"9666_CR75","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.gene.2018.05.009","volume":"666","author":"TT Zhao","year":"2018","unstructured":"Zhao, T. T., Yang, T. L., Gong, L., & Wu, P. (2018). Isorhamnetin protects against hypoxia\/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes. Gene, 666, 92\u201399. https:\/\/doi.org\/10.1016\/j.gene.2018.05.009","journal-title":"Gene"},{"key":"9666_CR76","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fphar.2017.00353","volume":"8","author":"M Wang","year":"2017","unstructured":"Wang, M., Sun, G. B., Du, Y. Y., Tian, Y., Liao, P., Liu, X. S., Ye, J. X., & Sun, X. B. (2017). Myricitrin protects cardiomyocytes from hypoxia\/reoxygenation injury: Involvement of heat shock protein 90. Frontiers in Pharmacology, 8, 353. https:\/\/doi.org\/10.3389\/fphar.2017.00353","journal-title":"Frontiers in Pharmacology"},{"key":"9666_CR77","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.gene.2017.07.063","volume":"629","author":"R Xiao","year":"2017","unstructured":"Xiao, R., Xiang, A. L., Pang, H. B., & Liu, K. Q. (2017). Hyperoside protects against hypoxia\/reoxygenation induced injury in cardiomyocytes by suppressing the Bnip3 expression. Gene, 629, 86\u201391. https:\/\/doi.org\/10.1016\/j.gene.2017.07.063","journal-title":"Gene"},{"key":"9666_CR78","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.biopha.2017.08.128","volume":"95","author":"H Cao","year":"2017","unstructured":"Cao, H., Xu, H., Zhu, G., & Liu, S. (2017). Isoquercetin ameliorated hypoxia\/reoxygenation-induced H9C2 cardiomyocyte apoptosis via a mitochondrial-dependent pathway. Biomedicine & Pharmacotherapy, 95, 938\u2013943. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.128","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"3","key":"9666_CR79","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.3892\/ijmm.2018.3743","volume":"42","author":"S Liu","year":"2018","unstructured":"Liu, S., Wu, N., Miao, J., Huang, Z., Li, X., Jia, P., Guo, Y., & Jia, D. (2018). Protective effect of morin on myocardial ischemia-reperfusion injury in rats. International Journal of Molecular Medicine, 42(3), 1379\u20131390. https:\/\/doi.org\/10.3892\/ijmm.2018.3743","journal-title":"International Journal of Molecular Medicine"},{"key":"9666_CR80","doi-asserted-by":"publisher","first-page":"7683051","DOI":"10.1155\/2019\/7683051","volume":"2019","author":"O Lozano","year":"2019","unstructured":"Lozano, O., L\u00e1zaro-Alfaro, A., Silva-Platas, C., Oropeza-Almaz\u00e1n, Y., Torres-Quintanilla, A., Bernal-Ram\u00edrez, J., Alves-Figueiredo, H., & Garc\u00eda-Rivas, G. (2019). Nanoencapsulated quercetin improves cardioprotection during hypoxia-reoxygenation injury through preservation of mitochondrial function. Oxidative Medicine and Cellular Longevity, 2019, 7683051. https:\/\/doi.org\/10.1155\/2019\/7683051","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"9666_CR81","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.cbi.2018.10.016","volume":"297","author":"H Yang","year":"2019","unstructured":"Yang, H., Wang, C., Zhang, L., Lv, J., & Ni, H. (2019). Rutin alleviates hypoxia\/reoxygenation-induced injury in myocardial cells by upregulating SIRT1 expression. Chemico Biological Interactions, 297, 44\u201349. https:\/\/doi.org\/10.1016\/j.cbi.2018.10.016","journal-title":"Chemico Biological Interactions"},{"issue":"11","key":"9666_CR82","doi-asserted-by":"publisher","first-page":"e0241007","DOI":"10.1371\/journal.pone.0241007","volume":"15","author":"J Huang","year":"2020","unstructured":"Huang, J., & Qi, Z. (2020). MiR-21 mediates the protection of kaempferol against hypoxia\/reoxygenation-induced cardiomyocyte injury via promoting Notch1\/PTEN\/AKT signalling pathway. PLoS ONE, 15(11), e0241007. https:\/\/doi.org\/10.1371\/journal.pone.0241007","journal-title":"PLoS ONE"},{"issue":"1","key":"9666_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-59894-4","volume":"10","author":"S Rodius","year":"2020","unstructured":"Rodius, S., de Klein, N., Jeanty, C., S\u00e1nchez-Iranzo, H., Crespo, I., Ibberson, M., Xenarios, I., Dittmar, G., Mercader, N., Niclou, S. P., & Azuaje, F. (2020). Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity. Science and Reports, 10(1), 1\u201312. https:\/\/doi.org\/10.1038\/s41598-020-59894-4","journal-title":"Science and Reports"},{"issue":"5","key":"9666_CR84","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/ajcn\/nqz178","volume":"110","author":"G Raman","year":"2019","unstructured":"Raman, G., Avendano, E. E., Chen, S., Wang, J., Matson, J., Gayer, B., Novotny, J. A., & Cassidy, A. (2019). Dietary intakes of flavan-3-ols and cardiometabolic health: Systematic review and meta-analysis of randomised trials and prospective cohort studies. American Journal of Clinical Nutrition, 110(5), 1067\u20131078. https:\/\/doi.org\/10.1093\/ajcn\/nqz178","journal-title":"American Journal of Clinical Nutrition"},{"issue":"12","key":"9666_CR85","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1007\/s10495-016-1306-6","volume":"21","author":"S Liu","year":"2016","unstructured":"Liu, S., Ai, Q., Feng, K., Li, Y., & Liu, X. (2016). The cardioprotective effect of dihydromyricetin prevents ischemia\u2013reperfusion-induced apoptosis in vivo and in vitro via the PI3K\/Akt and HIF-1\u03b1 signalling pathways. Apoptosis, 21(12), 1366\u20131385. https:\/\/doi.org\/10.1007\/s10495-016-1306-6","journal-title":"Apoptosis"},{"issue":"2","key":"9666_CR86","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3892\/ijmm.2017.3014","volume":"40","author":"Y Wu","year":"2017","unstructured":"Wu, Y., Xia, Z. Y., Zhao, B., Leng, Y., Dou, J., Meng, Q. T., Lei, S. Q., Chen, Z. Z., & Zhu, J. (2017). Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia\/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions. International Journal of Molecular Medicine, 40(2), 389\u2013399. https:\/\/doi.org\/10.3892\/ijmm.2017.3014","journal-title":"International Journal of Molecular Medicine"},{"key":"9666_CR87","doi-asserted-by":"publisher","first-page":"152845","DOI":"10.1016\/j.phymed.2019.152845","volume":"61","author":"C Zhang","year":"2019","unstructured":"Zhang, C., Liao, P., Liang, R., Zheng, X., & Jian, J. (2019). Epigallocatechin gallate prevents mitochondrial impairment and cell apoptosis by regulating miR-30a\/p53 axis. Phytomedicine, 61, 152845. https:\/\/doi.org\/10.1016\/j.phymed.2019.152845","journal-title":"Phytomedicine"},{"issue":"2","key":"9666_CR88","first-page":"79","volume":"65","author":"A Kozlowska","year":"2014","unstructured":"Kozlowska, A., & Szostak-Wegierek, D. (2014). Flavonoids-food sources and health benefits. Roczniki Pa\u0144stwowego Zak\u0142adu Higieny, 65(2), 79.","journal-title":"Roczniki Pa\u0144stwowego Zak\u0142adu Higieny"},{"key":"9666_CR89","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.biopha.2017.05.003","volume":"91","author":"S He","year":"2017","unstructured":"He, S., Wang, X., Zhong, Y., Tang, L., Zhang, Y., Ling, Y., Tan, Z., Yang, P., & Chen, A. (2017). Hesperetin post-treatment prevents rat cardiomyocytes from hypoxia\/reoxygenation injury in vitro via activating PI3K\/Akt signalling pathway. Biomedicine & Pharmacotherapy, 91, 1106\u20131112. https:\/\/doi.org\/10.1016\/j.biopha.2017.05.003","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"424","key":"9666_CR90","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11010-016-2848-1","volume":"2017","author":"J-Y Tang","year":"2017","unstructured":"Tang, J.-Y., Ping, J., Qing, H., Lu, L.-H., Ma, J.-P., Gao, W.-L., Bai, H.-P., & Yang, J. (2017). Naringenin ameliorates hypoxia\/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1\u03b1 and PERK signalling activation. Molecular Cellular and Biochemistry, 2017(424), 111\u2013122.","journal-title":"Molecular Cellular and Biochemistry"},{"issue":"1","key":"9666_CR91","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3892\/etm.2018.6918","volume":"17","author":"Y Xie","year":"2019","unstructured":"Xie, Y., Ji, R., & Han, M. (2019). Eriodictyol protects H9c2 cardiomyocytes against the injury induced by hypoxia\/reoxygenation by improving the dysfunction of mitochondria. Experimental and Therapeutic Medicine, 17(1), 551\u2013557. https:\/\/doi.org\/10.3892\/etm.2018.6918","journal-title":"Experimental and Therapeutic Medicine"},{"key":"9666_CR92","volume-title":"Sustainable protein sources: Soy protein: Impacts, production, and applications","author":"M Thrane","year":"2017","unstructured":"Thrane, M., Paulsen, P. V., Orcutt, M. W., & Krieger, T. M. (2017). Sustainable protein sources: Soy protein: Impacts, production, and applications. CAmbridge: Academic Press."},{"key":"9666_CR93","doi-asserted-by":"publisher","first-page":"977","DOI":"10.12659\/MSM.897379","volume":"22","author":"Y Ma","year":"2016","unstructured":"Ma, Y., Gai, Y., Yan, J., Jian, J., & Zhang, Y. (2016). Puerarin attenuates anoxia\/reoxygenation injury through enhancing Bcl-2 associated athanogene 3 expression, a modulator of apoptosis and autophagy. International Journal of Clinical and Experimental Medicine Research, 22, 977. https:\/\/doi.org\/10.12659\/MSM.897379","journal-title":"International Journal of Clinical and Experimental Medicine Research"},{"issue":"6","key":"9666_CR94","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.3892\/mmr.2017.6424","volume":"15","author":"H Tang","year":"2017","unstructured":"Tang, H., Song, X., Ling, Y., Wang, X., Yang, P., Luo, T., & Chen, A. (2017). Puerarin attenuates myocardial hypoxia\/reoxygenation injury by inhibiting autophagy via the Akt signalling pathway. Molecular Medicine Reports, 15(6), 3747\u20133754. https:\/\/doi.org\/10.3892\/mmr.2017.6424","journal-title":"Molecular Medicine Reports"},{"issue":"1","key":"9666_CR95","doi-asserted-by":"publisher","first-page":"1361779","DOI":"10.1080\/16546628.2017.1361779","volume":"61","author":"HE Khoo","year":"2017","unstructured":"Khoo, H. E., Azlan, A., Tang, S. T., & Lim, S. M. (2017). Anthocyanidins and anthocyanins: Colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food & Nutrition Research, 61(1), 1361779. https:\/\/doi.org\/10.1080\/16546628.2017.1361779","journal-title":"Food & Nutrition Research"},{"issue":"6","key":"9666_CR96","doi-asserted-by":"publisher","first-page":"9189","DOI":"10.3892\/mmr.2017.7756","volume":"16","author":"X Wang","year":"2017","unstructured":"Wang, X., Jia, D., Zhang, J., & Wang, W. (2017). Grape seed proanthocyanidins protect cardiomyocytes against hypoxia\/reoxygenation injury by attenuating endoplasmic reticulum stress through PERK\/eIF2\u03b1 pathway. Molecular Medicine Reports, 16(6), 9189\u20139196. https:\/\/doi.org\/10.3892\/mmr.2017.7756","journal-title":"Molecular Medicine Reports"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09666-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-021-09666-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09666-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T16:18:49Z","timestamp":1626970729000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-021-09666-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":96,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["9666"],"URL":"https:\/\/doi.org\/10.1007\/s12012-021-09666-x","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,10]]},"assertion":[{"value":"11 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}