{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:49:16Z","timestamp":1740138556464,"version":"3.37.3"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["3\/1\/3\/PDF (18)\/2018-HRD"],"award-info":[{"award-number":["3\/1\/3\/PDF (18)\/2018-HRD"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12012-021-09675-w","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T14:02:30Z","timestamp":1627135350000},"page":"848-858","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesity Potentiates the Risk of Drug-Induced Long QT Syndrome - Preliminary Evidence from WNIN\/Ob Spontaneously Obese Rat"],"prefix":"10.1007","volume":"21","author":[{"given":"Ajay Godwin","family":"Potnuri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kallamadi Prathap","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pothani","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulam Mohammed","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munawwar Husain","family":"Kazmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nemani","family":"Harishankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,24]]},"reference":[{"issue":"10","key":"9675_CR1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/0002-9149(86)90606-5","volume":"57","author":"K Wheelan","year":"1986","unstructured":"Wheelan, K., Mukharji, J., Rude, R. E., Poole, W. K., Gustafson, N., Thomas, L. J., Strauss, H. W., Jaffe, A. S., Muller, J. E., Roberts, R., Croft, C. H., Passamani, E. R., & Willerson, J. T. (1986). Sudden death and its relation to QT-interval prolongation after acute myocardial infarction: Two-year follow-up. American Journal of Cardiology, 57(10), 745\u2013750. https:\/\/doi.org\/10.1016\/0002-9149(86)90606-5","journal-title":"American Journal of Cardiology"},{"issue":"5","key":"9675_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/2042098612454283","volume":"3","author":"S Nachimuthu","year":"2012","unstructured":"Nachimuthu, S., Assar, M. D., & Schussler, J. M. (2012). Drug-induced QT interval prolongation: Mechanisms and clinical management. Therapeutic Advances in Drug Safety, 3(5), 241\u2013253. https:\/\/doi.org\/10.1177\/2042098612454283","journal-title":"Therapeutic Advances in Drug Safety"},{"issue":"7","key":"9675_CR3","first-page":"473","volume":"42","author":"M Li","year":"2017","unstructured":"Li, M., & Ramos, L. G. (2017). Drug-induced QT prolongation and torsades de pointes. Pharmacy and Therapeutics, 42(7), 473\u2013477.","journal-title":"Pharmacy and Therapeutics"},{"issue":"3","key":"9675_CR4","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1365-2125.2008.03229.x","volume":"66","author":"M Molokhia","year":"2008","unstructured":"Molokhia, M., Pathak, A., Lapeyre-Mestre, M., Caturla, L., Montastruc, J. L., McKeigue, P., & L\u2019AssociationFran\u00e7aise des CentresR\u00e9gionaux de Pharmacovigilance (CRPV). (2008). Case ascertainment and estimated incidence of drug-induced long-QT syndrome: Study in Southwest France. British Journal of Clinical Pharmacology, 66(3), 386\u2013395. https:\/\/doi.org\/10.1111\/j.1365-2125.2008.03229.x","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"1","key":"9675_CR5","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/europace\/eut214","volume":"16","author":"G Sarganas","year":"2014","unstructured":"Sarganas, G., Garbe, E., Klimpel, A., Hering, R. C., Bronder, E., & Haverkamp, W. (2014). Epidemiology of symptomatic drug-induced long QT syndrome and Torsade de Pointes in Germany. Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 16(1), 101\u2013108. https:\/\/doi.org\/10.1093\/europace\/eut214","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology: Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology"},{"issue":"20","key":"9675_CR6","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1056\/NEJMoa1003833","volume":"366","author":"WA Ray","year":"2012","unstructured":"Ray, W. A., Murray, K. T., Hall, K., Arbogast, P. G., & Stein, C. M. (2012). Azithromycin and the risk of cardiovascular death. New England Journal of Medicine, 366(20), 1881\u20131890. https:\/\/doi.org\/10.1056\/NEJMoa1003833","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"9675_CR7","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1056\/NEJMoa040582","volume":"351","author":"WA Ray","year":"2004","unstructured":"Ray, W. A., Murray, K. T., Meredith, S., Narasimhulu, S. S., Hall, K., & Stein, C. M. (2004). Oral erythromycin and the risk of sudden death from cardiac causes. The New England Journal of Medicine, 351(11), 1089\u20131096. https:\/\/doi.org\/10.1056\/NEJMoa040582","journal-title":"The New England Journal of Medicine"},{"issue":"3","key":"9675_CR8","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1001\/jamainternmed.2014.6294","volume":"175","author":"WA Ray","year":"2015","unstructured":"Ray, W. A., Chung, C. P., Murray, K. T., Cooper, W. O., Hall, K., & Stein, C. M. (2015). Out-of-hospital mortality among patients receiving methadone for noncancer pain. JAMA Internal Medicine, 175(3), 420\u2013427. https:\/\/doi.org\/10.1001\/jamainternmed.2014.6294","journal-title":"JAMA Internal Medicine"},{"issue":"6","key":"9675_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2155-9880.S10-006","volume":"10","author":"CE Leonard","year":"2013","unstructured":"Leonard, C. E., Freeman, C. P., Newcomb, C. W., Bilker, W. B., Kimmel, S. E., Strom, B. L., & Hennessy, S. (2013). Antipsychotics and the risks of sudden cardiac death and all-cause death: Cohort studies in medicaid and dually-eligible medicaid\u2013medicare beneficiaries of five states. Journal of Clinical & Experimental Cardiology, 10(6), 1\u20139. https:\/\/doi.org\/10.4172\/2155-9880.S10-006","journal-title":"Journal of Clinical & Experimental Cardiology"},{"issue":"6","key":"9675_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/FJC.0000000000000073","volume":"63","author":"CM Holmgren","year":"2014","unstructured":"Holmgren, C. M., Abdon, N. J., Bergfeldt, L. B., Edvardsson, N. G., Herlitz, J. D., Karlsson, T., & \u00c5strand, B. H. (2014). Changes in medication preceding out-of-hospital cardiac arrest where resuscitation was attempted. Journal of Cardiovascular Pharmacology, 63(6), 497\u2013503. https:\/\/doi.org\/10.1097\/FJC.0000000000000073","journal-title":"Journal of Cardiovascular Pharmacology"},{"issue":"2","key":"9675_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0033-0620(88)90014-x","volume":"31","author":"WM Jackman","year":"1988","unstructured":"Jackman, W. M., Friday, K. J., Anderson, J. L., Aliot, E. M., Clark, M., & Lazzara, R. (1988). The long QT syndromes: A critical review, new clinical observations and a unifying hypothesis. Progress in Cardiovascular Diseases, 31(2), 115\u2013172. https:\/\/doi.org\/10.1016\/0033-0620(88)90014-x","journal-title":"Progress in Cardiovascular Diseases"},{"issue":"21","key":"9675_CR12","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1001\/jama.1993.03510210076031","volume":"270","author":"RR Makkar","year":"1993","unstructured":"Makkar, R. R., Fromm, B. S., Steinman, R. T., Meissner, M. D., & Lehmann, M. H. (1993). Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA, 270(21), 2590\u20132597. https:\/\/doi.org\/10.1001\/jama.1993.03510210076031","journal-title":"JAMA"},{"issue":"8","key":"9675_CR13","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1161\/CIRCULATIONAHA.109.192704","volume":"121","author":"BJ Drew","year":"2010","unstructured":"Drew, B. J., Ackerman, M. J., Marjorie, F., Brian, G. W., Paul, K., Venu, M., Wojciech, Z., American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, & Council on Cardiovascular Nursing. (2010). Prevention of Torsade de Pointes in hospital settings. Circulation, 121(8), 1047\u20131060. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192704","journal-title":"Circulation"},{"issue":"4","key":"9675_CR14","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s13679-016-0235-6","volume":"5","author":"MA Alpert","year":"2016","unstructured":"Alpert, M. A., Omran, J., & Bostick, B. P. (2016). Effects of obesity on cardiovascular hemodynamics, cardiac morphology, and ventricular function. Current Obesity Reports, 5(4), 424\u2013434. https:\/\/doi.org\/10.1007\/s13679-016-0235-6","journal-title":"Current Obesity Reports"},{"key":"9675_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s40608-018-0190-8","author":"C Santos","year":"2018","unstructured":"Santos, C., & Marques da Silva, P. (2018). Hemodynamic patterns in obesity associated hypertension. BMC Obesity. https:\/\/doi.org\/10.1186\/s40608-018-0190-8","journal-title":"BMC Obesity"},{"issue":"2","key":"9675_CR16","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1152\/ajpheart.00450.2003","volume":"286","author":"AJ Grippo","year":"2004","unstructured":"Grippo, A. J., Santos, C. M., Johnson, R. F., Beltz, T. G., Martins, J. B., Felder, R. B., & Johnson, A. K. (2004). Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression. American Journal of Physiology, Heart and Circulatory Physiology, 286(2), 619\u2013626. https:\/\/doi.org\/10.1152\/ajpheart.00450.2003","journal-title":"American Journal of Physiology, Heart and Circulatory Physiology"},{"issue":"10","key":"9675_CR17","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1161\/CIRCULATIONAHA.107.744466","volume":"117","author":"H Watanabe","year":"2008","unstructured":"Watanabe, H., Tanabe, N., Watanabe, T., Darbar, D., Roden, D. M., Sasaki, S., & Aizawa, Y. (2008). Metabolic syndrome and risk of development of atrial fibrillation. Circulation, 117(10), 1255\u20131260. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.107.744466","journal-title":"Circulation"},{"key":"9675_CR18","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1109\/IEMBS.2007.4352311","volume":"2007","author":"S Rossi","year":"2007","unstructured":"Rossi, S., Baruffi, S., Bertuzzi, A., Mastorci, F., Sgoifo, A., Musso, E., Corradi, D., Maestri, R., Brisinda, D., Fenici, R., & Macchi, E. (2007). Susceptibility to ventricular arrhythmias in aged hearts. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2007, 410\u2013414. https:\/\/doi.org\/10.1109\/IEMBS.2007.4352311","journal-title":"Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference"},{"key":"9675_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1476-511X-13-25","volume":"13","author":"RR Kalashikam","year":"2014","unstructured":"Kalashikam, R. R., Inagadapa, P. J. N., Thomas, A. E., Jeyapal, S., Giridharan, N. V., & Raghunath, M. (2014). Leptin gene promoter DNA methylation in WNIN obese mutant rats. Lipids in Health and Disease, 13, 25. https:\/\/doi.org\/10.1186\/1476-511X-13-25","journal-title":"Lipids in Health and Disease"},{"key":"9675_CR20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.neuroscience.2014.03.040","volume":"269","author":"JK Sinha","year":"2014","unstructured":"Sinha, J. K., Ghosh, S., Swain, U., Giridharan, N. V., & Raghunath, M. (2014). Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN\/Ob, a novel rat model of premature aging. Neuroscience, 269, 256\u2013264. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.03.040","journal-title":"Neuroscience"},{"issue":"5","key":"9675_CR21","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/iub.1163","volume":"65","author":"PY Reddy","year":"2013","unstructured":"Reddy, P. Y., Giridharan, N. V., Balakrishna, N., Validandi, V., Pullakhandam, R., & Reddy, G. B. (2013). Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol. IUBMB Life, 65(5), 472\u2013478. https:\/\/doi.org\/10.1002\/iub.1163","journal-title":"IUBMB Life"},{"key":"9675_CR22","first-page":"495","volume":"18","author":"PY Reddy","year":"2012","unstructured":"Reddy, P. Y., Giridharan, N. V., & Reddy, G. B. (2012). Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-obese rats. Molecular Vision, 18, 495\u2013503.","journal-title":"Molecular Vision"},{"issue":"9","key":"9675_CR23","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1016\/j.bbagen.2014.06.005","volume":"1840","author":"SS Reddy","year":"2014","unstructured":"Reddy, S. S., Shruthi, K., Reddy, V. S., Raghu, G., Suryanarayana, P., Giridharan, N. V., & Reddy, G. B. (2014). Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model. Biochimica Et Biophysica Acta, 1840(9), 2924\u20132934. https:\/\/doi.org\/10.1016\/j.bbagen.2014.06.005","journal-title":"Biochimica Et Biophysica Acta"},{"key":"9675_CR24","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.lfs.2017.08.006","volume":"186","author":"D Strinic","year":"2017","unstructured":"Strinic, D., Halle, Z. B., Luetic, K., Nedic, A., Petrovic, I., Sucic, M., Posilovic, G. Z., Balenovic, D., Strbe, S., Udovicic, M., Drmic, D., Stupnisek, M., Bencic, M. L., Seiwerth, S., & Sikiric, P. (2017). BPC 157 counteracts QTc prolongation induced by haloperidol, fluphenazine, clozapine, olanzapine, quetiapine, sulpiride, and metoclopramide in rats. Life Sciences, 186, 66\u201379. https:\/\/doi.org\/10.1016\/j.lfs.2017.08.006","journal-title":"Life Sciences"},{"issue":"12","key":"9675_CR25","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1038\/s41440-018-0109-2","volume":"41","author":"AG Potnuri","year":"2018","unstructured":"Potnuri, A. G., Allakonda, L., Appavoo, A., Saheera, S., & Nair, R. R. (2018). Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol. Hypertension Research: Official Journal of the Japanese Society of Hypertension, 41(12), 1023\u20131035. https:\/\/doi.org\/10.1038\/s41440-018-0109-2","journal-title":"Hypertension Research: Official Journal of the Japanese Society of Hypertension"},{"issue":"7","key":"9675_CR26","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/0002-9149(92)90562-d","volume":"70","author":"A Sagie","year":"1992","unstructured":"Sagie, A., Larson, M. G., Goldberg, R. J., Bengtson, J. R., & Levy, D. (1992). An improved method for adjusting the QT interval for heart rate (the Framingham heart study). The American Journal of Cardiology, 70(7), 797\u2013801. https:\/\/doi.org\/10.1016\/0002-9149(92)90562-d","journal-title":"The American Journal of Cardiology"},{"issue":"3","key":"9675_CR27","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1249\/MSS.0b013e3182323f8b","volume":"44","author":"LE Miller","year":"2012","unstructured":"Miller, L. E., Hosick, P. A., Wrieden, J., Hoyt, E., & Quindry, J. C. (2012). Evaluation of arrhythmia scoring systems and exercise-induced cardioprotection. Medicine and Science in Sports and Exercise, 44(3), 435\u2013441. https:\/\/doi.org\/10.1249\/MSS.0b013e3182323f8b","journal-title":"Medicine and Science in Sports and Exercise"},{"issue":"9","key":"9675_CR28","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s00125-004-1506-4","volume":"47","author":"L Venu","year":"2004","unstructured":"Venu, L., Harishankar, N., Prasanna Krishna, T., & Raghunath, M. (2004). Maternal dietary vitamin restriction increases body fat content but not insulin resistance in WNIN rat offspring up to 6 months of age. Diabetologia, 47(9), 1493\u20131501. https:\/\/doi.org\/10.1007\/s00125-004-1506-4","journal-title":"Diabetologia"},{"key":"9675_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.10.040","author":"AG Potnuri","year":"2016","unstructured":"Potnuri, A. G., Allakonda, L., Appavoo, A., Saheera, S., & Nair, R. R. (2016). Targeting histamine-2 receptor for prevention of cardiac remodelling in chronic pressure overload. International Journal of Cardiology. https:\/\/doi.org\/10.1016\/j.ijcard.2015.10.040","journal-title":"International Journal of Cardiology"},{"issue":"6","key":"9675_CR30","doi-asserted-by":"publisher","first-page":"H941","DOI":"10.1152\/ajpheart.1982.243.6.H941","volume":"243","author":"FC Yin","year":"1982","unstructured":"Yin, F. C., Spurgeon, H. A., Rakusan, K., Weisfeldt, M. L., & Lakatta, E. G. (1982). Use of tibial length to quantify cardiac hypertrophy: Application in the aging rat. The American Journal of Physiology, 243(6), H941-947. https:\/\/doi.org\/10.1152\/ajpheart.1982.243.6.H941","journal-title":"The American Journal of Physiology"},{"issue":"3","key":"9675_CR31","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","volume":"29","author":"GK Reddy","year":"1996","unstructured":"Reddy, G. K., & Enwemeka, C. S. (1996). A simplified method for the analysis of hydroxyproline in biological tissues. Clinical Biochemistry, 29(3), 225\u2013229. https:\/\/doi.org\/10.1016\/0009-9120(96)00003-6","journal-title":"Clinical Biochemistry"},{"issue":"6","key":"9675_CR32","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/0002-8703(86)90010-4","volume":"111","author":"DM Roden","year":"1986","unstructured":"Roden, D. M., Woosley, R. L., & Primm, R. K. (1986). Incidence and clinical features of the quinidine-associated long QT syndrome: Implications for patient care. American Heart Journal, 111(6), 1088\u20131093. https:\/\/doi.org\/10.1016\/0002-8703(86)90010-4","journal-title":"American Heart Journal"},{"issue":"11","key":"9675_CR33","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1176\/appi.ajp.158.11.1774","volume":"158","author":"AH Glassman","year":"2001","unstructured":"Glassman, A. H., & Bigger, J. T. (2001). Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death. The American Journal of Psychiatry, 158(11), 1774\u20131782. https:\/\/doi.org\/10.1176\/appi.ajp.158.11.1774","journal-title":"The American Journal of Psychiatry"},{"issue":"4","key":"9675_CR34","doi-asserted-by":"publisher","first-page":"E8","DOI":"10.1002\/jhm.691","volume":"5","author":"C Meyer-Massetti","year":"2010","unstructured":"Meyer-Massetti, C., Cheng, C. M., Sharpe, B. A., Meier, C. R., & Guglielmo, B. J. (2010). The FDA extended warning for intravenous haloperidol and torsades de pointes: How should institutions respond? Journal of Hospital Medicine, 5(4), E8-16. https:\/\/doi.org\/10.1002\/jhm.691","journal-title":"Journal of Hospital Medicine"},{"issue":"6","key":"9675_CR35","doi-asserted-by":"publisher","first-page":"401","DOI":"10.11909\/j.issn.1671-5411.2018.06.003","volume":"15","author":"EJ Schrijver","year":"2018","unstructured":"Schrijver, E. J., Verstraaten, M., Van De Ven, P. M., Bet, P. M., Van Strien, A. M., De Cock, C., & Nanayakkara, P. W. (2018). Low dose oral haloperidol does not prolong QTc interval in older acutely hospitalised adults: a subanalysis of a randomised double-blind placebo-controlled study. Journal of Geriatric Cardiology, 15(6), 401\u2013407. https:\/\/doi.org\/10.11909\/j.issn.1671-5411.2018.06.003","journal-title":"Journal of Geriatric Cardiology"},{"issue":"4","key":"9675_CR36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1161\/CIRCRESAHA.107.150417","volume":"101","author":"GD Lopaschuk","year":"2007","unstructured":"Lopaschuk, G. D., Folmes Clifford, D. L., & Stanley, W. C. (2007). Cardiac energy metabolism in obesity. Circulation Research, 101(4), 335\u2013347. https:\/\/doi.org\/10.1161\/CIRCRESAHA.107.150417","journal-title":"Circulation Research"},{"issue":"3","key":"9675_CR37","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/jhh.2015.58","volume":"30","author":"JC Rodrigues","year":"2016","unstructured":"Rodrigues, J. C., McIntyre, B., Dastidar, A. G., Lyen, S. M., Ratcliffe, L. E., Burchell, A. E., Hart, E. C., Bucciarelli-Ducci, C., Hamilton, M. C., Paton, J. F., Nightingale, A. K., & Manghat, N. E. (2016). The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: Recalibration against cardiac magnetic resonance. Journal of Human Hypertension, 30(3), 197\u2013203. https:\/\/doi.org\/10.1038\/jhh.2015.58","journal-title":"Journal of Human Hypertension"},{"issue":"1","key":"9675_CR38","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13098-017-0238-9","volume":"9","author":"TW Elffers","year":"2017","unstructured":"Elffers, T. W., de Mutsert, R., Lamb, H. J., Maan, A. C., Macfarlane, P. W., van Dijk, K. W., Rosendaal, F. R., Jukema, J. W., & Trompet, S. (2017). Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease. Diabetology & Metabolic Syndrome, 9(1), 40. https:\/\/doi.org\/10.1186\/s13098-017-0238-9","journal-title":"Diabetology & Metabolic Syndrome"},{"key":"9675_CR39","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001654","author":"K Narayanan","year":"2015","unstructured":"Narayanan, K., Zhang, L., Kim, C., Uy-Evanado, A., Teodorescu, C., Reinier, K., Zheng, Z. J., Gunson, K., Jui, J., & Chugh, S. S. (2015). QRS fragmentation and sudden cardiac death in the obese and overweight. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease. https:\/\/doi.org\/10.1161\/JAHA.114.001654","journal-title":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease"},{"key":"9675_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00002","author":"JMB Anumonwo","year":"2018","unstructured":"Anumonwo, J. M. B., & Herron, T. (2018). Fatty infiltration of the myocardium and arrhythmogenesis: Potential cellular and molecular mechanisms. Frontiers in Physiology. https:\/\/doi.org\/10.3389\/fphys.2018.00002","journal-title":"Frontiers in Physiology"},{"issue":"3","key":"9675_CR41","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/20961790.2019.1633761","volume":"4","author":"KS Cunningham","year":"2019","unstructured":"Cunningham, K. S., Spears, D. A., & Care, M. (2019). Evaluation of cardiac hypertrophy in the setting of sudden cardiac death. Forensic Sciences Research, 4(3), 223\u2013240. https:\/\/doi.org\/10.1080\/20961790.2019.1633761","journal-title":"Forensic Sciences Research"},{"issue":"3","key":"9675_CR42","first-page":"124","volume":"9","author":"SM Artham","year":"2009","unstructured":"Artham, S. M., Lavie, C. J., Milani, R. V., & Ventura, H. O. (2009). Obesity and hypertension, heart failure, and coronary heart disease\u2014risk factor, paradox, and recommendations for weight loss. The Ochsner Journal, 9(3), 124\u2013132.","journal-title":"The Ochsner Journal"},{"issue":"1","key":"9675_CR43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1001\/archinte.1981.00340010073016","volume":"141","author":"FH Messerli","year":"1981","unstructured":"Messerli, F. H., Christie, B., DeCarvalho, J. G. R., Aristimuno, G. G., Suarez, D. H., Dreslinski, G. R., & Frohlich, E. D. (1981). Obesity and essential hypertension: hemodynamics, intravascular volume, sodium excretion, and plasma renin activity. Archives of Internal Medicine, 141(1), 81\u201385. https:\/\/doi.org\/10.1001\/archinte.1981.00340010073016","journal-title":"Archives of Internal Medicine"},{"key":"9675_CR44","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.14","author":"WS Aronow","year":"2017","unstructured":"Aronow, W. S. (2017). Hypertension and left ventricular hypertrophy. Annals of Translational Medicine. https:\/\/doi.org\/10.21037\/atm.2017.06.14","journal-title":"Annals of Translational Medicine"},{"issue":"2","key":"9675_CR45","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/s0002-9149(97)00869-2","volume":"81","author":"JR Gonz\u00e1lez-Juanatey","year":"1998","unstructured":"Gonz\u00e1lez-Juanatey, J. R., Garc\u00eda-Acu\u00f1a, J. M., Pose, A., Varela, A., Calvo, C., Cabezas-Cerrato, J., & de la Pe\u00f1a, M. G. (1998). Reduction of QT and QTc dispersion during long-term treatment of systemic hypertension with enalapril. The American Journal of Cardiology, 81(2), 170\u2013174. https:\/\/doi.org\/10.1016\/s0002-9149(97)00869-2","journal-title":"The American Journal of Cardiology"},{"key":"9675_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00904","author":"C de Lucia","year":"2018","unstructured":"de Lucia, C., Eguchi, A., & Koch, W. J. (2018). New insights in cardiac \u03b2-adrenergic signaling during heart failure and aging. Frontiers in Pharmacology. https:\/\/doi.org\/10.3389\/fphar.2018.00904","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"9675_CR47","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0022-0736(82)80044-7","volume":"15","author":"RB Devereux","year":"1982","unstructured":"Devereux, R. B., & Reichek, N. (1982). Repolarization abnormalities of left ventricular hypertrophy. Clinical, echocardiographic and hemodynamic correlates. Journal of Electrocardiology, 15(1), 47\u201353. https:\/\/doi.org\/10.1016\/S0022-0736(82)80044-7","journal-title":"Journal of Electrocardiology"},{"issue":"5","key":"9675_CR48","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/15376516.2012.666650","volume":"22","author":"SK Maulik","year":"2012","unstructured":"Maulik, S. K., & Kumar, S. (2012). Oxidative stress and cardiac hypertrophy: A review. Toxicology Mechanisms and Methods, 22(5), 359\u2013366. https:\/\/doi.org\/10.3109\/15376516.2012.666650","journal-title":"Toxicology Mechanisms and Methods"},{"issue":"6","key":"9675_CR49","doi-asserted-by":"publisher","first-page":"353","DOI":"10.4330\/wjc.v6.i6.353","volume":"6","author":"J Gonz\u00e1lez","year":"2014","unstructured":"Gonz\u00e1lez, J., Valls, N., Brito, R., & Rodrigo, R. (2014). Essential hypertension and oxidative stress: New insights. World Journal of Cardiology, 6(6), 353\u2013366. https:\/\/doi.org\/10.4330\/wjc.v6.i6.353","journal-title":"World Journal of Cardiology"},{"issue":"4","key":"9675_CR50","first-page":"358","volume":"19","author":"A Baradaran","year":"2014","unstructured":"Baradaran, A., Nasri, H., & Rafieian-Kopaei, M. (2014). Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 19(4), 358\u2013367.","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"issue":"8","key":"9675_CR51","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1253\/circj.CJ-13-1587","volume":"78","author":"S Kurokawa","year":"2014","unstructured":"Kurokawa, S., Niwano, S., Niwano, H., Murakami, M., Ishikawa, S., Masaki, Y., Tamaki, H., Toda, T., Noda, Y., Shimizu, T., Izumi, T., & Ako, J. (2014). Cardiomyocyte-derived mitochondrial superoxide causes myocardial electrical remodeling by downregulating potassium channels and related molecules. Circulation Journal, 78(8), 1950\u20131959. https:\/\/doi.org\/10.1253\/circj.CJ-13-1587","journal-title":"Circulation Journal"},{"key":"9675_CR52","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.trsl.2019.03.004","volume":"209","author":"RT Cowling","year":"2019","unstructured":"Cowling, R. T., Kupsky, D., Kahn, A. M., Daniels, L. B., & Greenberg, B. H. (2019). Mechanisms of cardiac collagen deposition in experimental models and human disease. Translational Research: The Journal of Laboratory and Clinical Medicine, 209, 138\u2013155. https:\/\/doi.org\/10.1016\/j.trsl.2019.03.004","journal-title":"Translational Research: The Journal of Laboratory and Clinical Medicine"},{"issue":"11","key":"9675_CR53","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1021\/bi00359a016","volume":"25","author":"G N\u00e9methy","year":"1986","unstructured":"N\u00e9methy, G., & Scheraga, H. A. (1986). Stabilization of collagen fibrils by hydroxyproline. Biochemistry, 25(11), 3184\u20133188. https:\/\/doi.org\/10.1021\/bi00359a016","journal-title":"Biochemistry"},{"key":"9675_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/704291","author":"T Sunagawa","year":"2014","unstructured":"Sunagawa, T., Shimizu, T., Matsumoto, A., Tagashira, M., Kanda, T., Shirasawa, T., & Nakaya, H. (2014). Cardiac electrophysiological alterations in heart\/muscle-specific manganese-superoxide dismutase-deficient mice: Prevention by a dietary antioxidant polyphenol. BioMed Research International. https:\/\/doi.org\/10.1155\/2014\/704291","journal-title":"BioMed Research International"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09675-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-021-09675-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-021-09675-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T14:11:36Z","timestamp":1630159896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-021-09675-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,24]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["9675"],"URL":"https:\/\/doi.org\/10.1007\/s12012-021-09675-w","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"type":"print","value":"1530-7905"},{"type":"electronic","value":"1559-0259"}],"subject":[],"published":{"date-parts":[[2021,7,24]]},"assertion":[{"value":"5 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study is approved by Institutional Animal Ethics Committee [Sanction No: ICMR-NIN\/IAEC\/02\/009\/2019].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Consent for publication is given by all authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}