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In this study, we present two cases, a case series and a scoping review, to explore synthetic cathinone associated cardiotoxicity. Case 1 involved a 28-year-old male with non-ST-elevation myocardial infarction after ingesting a substance containing 4-methylmethcathinone (4-MMC), 3-methylmethcathinon (3-MMC), and methcathinone. Case 2 involved a 49-year-old male with ventricular fibrillation after 4-methylmethcathinone ingestion, who was diagnosed with severe three-vessel disease. A retrospective analysis was performed on self-reported synthetic cathinone poisonings reported to the Dutch Poisons Information Centre from 2012 to 2022. A total of 222 mono-intoxications with cardiotoxicity were included, mostly involving 3-methylmethcathinon (63%). Often tachycardia, hypertension, palpitations, and chest pain were reported. A comprehensive literature search was performed on PubMed to identify the studies reporting cardiac arrest, myocardial infarction, cardiac inflammation, cardiomyopathy, and life-threatening arrhythmias following synthetic cathinone use. A total of 30 articles reporting 40 cases were included. The reported complications included cardiac arrest (<jats:italic>n<\/jats:italic>\u2009=\u200928), ventricular tachycardia (<jats:italic>n<\/jats:italic>\u2009=\u20094), supraventricular tachycardia (<jats:italic>n<\/jats:italic>\u2009=\u20091), ST-elevation myocardial infarction (<jats:italic>n<\/jats:italic>\u2009=\u20092), non-ST-elevation myocardial infarction (<jats:italic>n<\/jats:italic>\u2009=\u20092), cardiomyopathy (<jats:italic>n<\/jats:italic>\u2009=\u20091), and myocarditis (<jats:italic>n<\/jats:italic>\u2009=\u20092). A total of ten different associated synthetic cathinones were identified. Cardiac arrest, myocardial infarction, and ventricular arrhythmias have been reported following the use of synthetic cathinones, underscoring the importance of obtaining a detailed recreational drug use history from patients presenting with syncope, chest pain, or palpitations.<\/jats:p>","DOI":"10.1007\/s12012-024-09832-x","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T13:02:24Z","timestamp":1709038944000},"page":"209-224","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Scoping Review"],"prefix":"10.1007","volume":"24","author":[{"given":"K. L.","family":"Groenewegen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. M. 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