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Renalase is a protein that may play a role in the pathogenesis of CVD. The aim of the study was to assess the relationship between ETS and serum renalase concentration. A group of 109 patients was recruited for this study (49.7\u2009\u00b1\u200914.7\u00a0years). In accordance with the questionnaire, patients were divided into the following subgroups: subgroup A\u2013 declaring themselves active smokers (<jats:italic>n<\/jats:italic>\u2009=\u200936), subgroup B\u2013 declaring themselves non-smokers and exposed to environmental tobacco smoke (<jats:italic>n<\/jats:italic>\u2009=\u200935), subgroup C\u2013 declaring themselves non-smokers and not exposed to environmental tobacco smoke (<jats:italic>n<\/jats:italic>\u2009=\u200938). The same patients were divided based on cotinine concentration into the following subgroups: subgroup D\u2013 active smokers (<jats:italic>n<\/jats:italic>\u2009=\u200942), subgroup E\u2013 non-smokers exposed to environmental tobacco smoke (<jats:italic>n<\/jats:italic>\u2009=\u200966), and subgroup F\u2013 non-smokers not exposed to environmental tobacco smoke (<jats:italic>n<\/jats:italic>\u2009=\u20091). Serum cotinine concentration and serum renalase concentration were measured using ELISA tests. Serum renalase concentration was statistically significantly higher in subgroup C than in subgroups A and B and in subgroup E and F than in D. There was a negative correlation between serum cotinine concentration and serum renalase concentration (r\u2009=\u2009\u22120.41, p\u2009&lt;\u20090.05). Regression analysis showed that higher BMI, higher diastolic blood pressure, coronary artery disease and higher serum cotinine concentration are independent risk factors of lower serum renalase concentration. The questionnaire method of assessing exposure to tobacco smoke was characterized by high sensitivity, but only moderate specificity, especially in terms of assessing environmental exposure to tobacco smoke. In summary, the study showed an independent relationship between exposure to tobacco smoke and lower serum renalase concentration.<\/jats:p>","DOI":"10.1007\/s12012-024-09868-z","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T12:02:04Z","timestamp":1715774524000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relation Between Exposure to Tobacco Smoke Assessed by Serum Cotinine Concentration and Questionnaire Method, and Serum Renalase Concentration\u2014the Importance of the Coexistence of Arterial Hypertension and Other Cardiovascular Diseases"],"prefix":"10.1007","volume":"24","author":[{"given":"Aleksandra","family":"\u017b\u00f3rawik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Hajdusianek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Kusner\u017c","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Markiewicz-G\u00f3rka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Jaremk\u00f3w","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Martynowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystyna","family":"Pawlas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"Por\u0119ba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Ga\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"issue":"9995","key":"9868_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S0140-6736(14)61468-9","volume":"386","author":"NR Poulter","year":"2015","unstructured":"Poulter, N. 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