{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:59:21Z","timestamp":1782442761413,"version":"3.54.5"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200473"],"award-info":[{"award-number":["82200473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070440"],"award-info":[{"award-number":["82070440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270468"],"award-info":[{"award-number":["82270468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009996","name":"Shaanxi Province Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023BSHYDZZ01"],"award-info":[{"award-number":["2023BSHYDZZ01"]}],"id":[{"id":"10.13039\/501100009996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M742801"],"award-info":[{"award-number":["2023M742801"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project supported by the Open Fund for Key Laboratory of precision medicine for children's diseases in Shaanxi province","award":["KFJJ2023-01"],"award-info":[{"award-number":["KFJJ2023-01"]}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBMS-764"],"award-info":[{"award-number":["2024JC-YBMS-764"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s12012-024-09938-2","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T17:02:53Z","timestamp":1730134973000},"page":"9-23","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Inhibition of CB1R in the Hypothalamic Paraventricular Nucleus Ameliorates Hypertension Through Wnt\/\u03b2-Catenin\/RAS Pathway"],"prefix":"10.1007","volume":"25","author":[{"given":"Hong-Li","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Yue","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ming","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"9938_CR1","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1161\/HYPERTENSIONAHA.122.19317","volume":"80","author":"NA Cameron","year":"2023","unstructured":"Cameron, N. A., Everitt, I. K., Lee, K. A., Yee, L. M., & Khan, S. S. (2023). Chronic hypertension in pregnancy: a lens into cardiovascular disease risk and prevention. Hypertension, 80, 1162\u20131170.","journal-title":"Hypertension"},{"key":"9938_CR2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1161\/HYPERTENSIONAHA.122.18085","volume":"80","author":"MM Santisteban","year":"2023","unstructured":"Santisteban, M. M., Iadecola, C., & Carnevale, D. (2023). Hypertension, neurovascular dysfunction, and cognitive impairment. Hypertension, 80, 22\u201334.","journal-title":"Hypertension"},{"key":"9938_CR3","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1161\/HYPERTENSIONAHA.119.13437","volume":"74","author":"VJ Dzau","year":"2019","unstructured":"Dzau, V. J., & Balatbat, C. A. (2019). Future of hypertension. Hypertension, 74, 450\u2013457.","journal-title":"Hypertension"},{"key":"9938_CR4","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1001\/jama.2022.19590","volume":"328","author":"RM Carey","year":"2022","unstructured":"Carey, R. M., Moran, A. E., & Whelton, P. K. (2022). Treatment of hypertension: a review. JAMA, 328, 1849\u20131861.","journal-title":"JAMA"},{"key":"9938_CR5","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.122.060860","volume":"147","author":"Y Higashikuni","year":"2023","unstructured":"Higashikuni, Y., Liu, W., Numata, G., Tanaka, K., Fukuda, D., Tanaka, Y., Hirata, Y., Imamura, T., Takimoto, E., Komuro, I., & Sata, M. (2023). NLRP3 inflammasome activation through heart-brain interaction initiates cardiac inflammation and hypertrophy during pressure overload. Circulation, 147, 338\u2013355.","journal-title":"Circulation"},{"key":"9938_CR6","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1161\/CIRCRESAHA.122.320976","volume":"131","author":"JJ Zhou","year":"2022","unstructured":"Zhou, J. J., Shao, J. Y., Chen, S. R., & Pan, H. L. (2022). Calcineurin controls hypothalamic NMDA receptor activity and sympathetic outflow. Circulation Research, 131, 345\u2013360.","journal-title":"Circulation Research"},{"key":"9938_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101186","volume":"24","author":"Y Wang","year":"2019","unstructured":"Wang, Y., Hu, H., Yin, J., Shi, Y., Tan, J., Zheng, L., Wang, C., Li, X., Xue, M., Liu, J., Wang, Y., Li, Y., Li, X., Liu, F., Liu, Q., & Yan, S. (2019). TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-kappaB pathway and ROS production. Redox Biology, 24, 101186.","journal-title":"Redox Biology"},{"key":"9938_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/HJH.0000000000003542","volume":"42","author":"MR Zahner","year":"2024","unstructured":"Zahner, M. R., Brown, M. C., & Chandley, M. J. (2024). Inactivation of the paraventricular nucleus attenuates the cardiogenic sympathetic afferent reflex in the spontaneously hypertensive rat. Journal of Hypertension, 42, 70\u201378.","journal-title":"Journal of Hypertension"},{"key":"9938_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154951","volume":"118","author":"XY Jia","year":"2023","unstructured":"Jia, X. Y., Jiang, D. L., Jia, X. T., Fu, L. Y., Tian, H., Liu, K. L., Qi, J., Kang, Y. M., & Yu, X. J. (2023). Capsaicin improves hypertension and cardiac hypertrophy via SIRT1\/NF-kappaB\/MAPKs pathway in the hypothalamic paraventricular nucleus. Phytomedicine, 118, 154951.","journal-title":"Phytomedicine"},{"key":"9938_CR10","doi-asserted-by":"publisher","first-page":"H1389","DOI":"10.1152\/ajpheart.00780.2018","volume":"316","author":"LAC Souza","year":"2019","unstructured":"Souza, L. A. C., Worker, C. J., Li, W., Trebak, F., Watkins, T., Gayban, A. J. B., Yamasaki, E., Cooper, S. G., Drumm, B. T., & Feng, Y. (2019). (Pro)renin receptor knockdown in the paraventricular nucleus of the hypothalamus attenuates hypertension development and AT(1) receptor-mediated calcium events. American Journal of Physiology. Heart and Circulatory Physiology, 316, H1389\u2013H1405.","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9938_CR11","doi-asserted-by":"crossref","unstructured":"Su, Q., Yu, X.J., Wang, X.M., Peng, B., Bai, J., Li, H.B., Li, Y., Xia, W.J., Fu, L.Y., Liu, K.L., Liu, J.J. and Kang, Y.M. (2022). Na(+)\/K(+)-ATPase Alpha 2 Isoform Elicits Rac1-Dependent Oxidative Stress and TLR4-Induced Inflammation in the Hypothalamic Paraventricular Nucleus in High Salt-Induced Hypertension. Antioxidants (Basel) 11.","DOI":"10.3390\/antiox11020288"},{"key":"9938_CR12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.apha.2017.03.007","volume":"80","author":"AC Howlett","year":"2017","unstructured":"Howlett, A. C., & Abood, M. E. (2017). CB(1) and CB(2) receptor pharmacology. Advances in Pharmacology, 80, 169\u2013206.","journal-title":"Advances in Pharmacology"},{"key":"9938_CR13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cellsig.2017.09.002","volume":"40","author":"D Haspula","year":"2017","unstructured":"Haspula, D., & Clark, M. A. (2017). MAPK activation patterns of AT1R and CB1R in SHR versus Wistar astrocytes: Evidence of CB1R hypofunction and crosstalk between AT1R and CB1R. Cellular Signalling, 40, 81\u201390.","journal-title":"Cellular Signalling"},{"key":"9938_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115102","volume":"201","author":"F Yao","year":"2022","unstructured":"Yao, F., & Abdel-Rahman, A. A. (2022). Estrogen dampens central cannabinoid receptor 1-mediated neuroexcitation and pressor response in conscious female rats. Biochemical Pharmacology, 201, 115102.","journal-title":"Biochemical Pharmacology"},{"key":"9938_CR15","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1161\/01.HYP.29.5.1204","volume":"29","author":"KD Lake","year":"1997","unstructured":"Lake, K. D., Martin, B. R., Kunos, G., & Varga, K. (1997). Cardiovascular effects of anandamide in anesthetized and conscious normotensive and hypertensive rats. Hypertension, 29, 1204\u20131210.","journal-title":"Hypertension"},{"key":"9938_CR16","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1161\/01.HYP.28.4.682","volume":"28","author":"K Varga","year":"1996","unstructured":"Varga, K., Lake, K. D., Huangfu, D., Guyenet, P. G., & Kunos, G. (1996). Mechanism of the hypotensive action of anandamide in anesthetized rats. Hypertension, 28, 682\u2013686.","journal-title":"Hypertension"},{"key":"9938_CR17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/sj.bjp.0705725","volume":"142","author":"MD Randall","year":"2004","unstructured":"Randall, M. D., Kendall, D. A., & O\u2019Sullivan, S. (2004). The complexities of the cardiovascular actions of cannabinoids. British Journal of Pharmacology, 142, 20\u201326.","journal-title":"British Journal of Pharmacology"},{"key":"9938_CR18","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.euroneuro.2018.08.002","volume":"28","author":"AM Cruz-Martinez","year":"2018","unstructured":"Cruz-Martinez, A. M., Tejas-Juarez, J. G., Mancilla-Diaz, J. M., Floran-Garduno, B., Lopez-Alonso, V. E., & Escartin-Perez, R. E. (2018). CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. European Neuropsychopharmacology, 28, 1247\u20131259.","journal-title":"European Neuropsychopharmacology"},{"key":"9938_CR19","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.2337\/db20-0078","volume":"69","author":"C Roger","year":"2020","unstructured":"Roger, C., Buch, C., Muller, T., Leemput, J., Demizieux, L., Passilly-Degrace, P., Cinar, R., Iyer, M. R., Kunos, G., Verges, B., Degrace, P., & Jourdan, T. (2020). Simultaneous inhibition of peripheral CB1R and iNOS mitigates obesity-related dyslipidemia through distinct mechanisms. Diabetes, 69, 2120\u20132132.","journal-title":"Diabetes"},{"key":"9938_CR20","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1093\/brain\/awac236","volume":"145","author":"Q Wang","year":"2022","unstructured":"Wang, Q., Huang, X., Su, Y., Yin, G., Wang, S., Yu, B., Li, H., Qi, J., Chen, H., Zeng, W., Zhang, K., Verkhratsky, A., Niu, J., & Yi, C. (2022). Activation of Wnt\/beta-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer\u2019s disease. Brain, 145, 4474\u20134488.","journal-title":"Brain"},{"key":"9938_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13004","volume":"18","author":"J Miao","year":"2019","unstructured":"Miao, J., Liu, J., Niu, J., Zhang, Y., Shen, W., Luo, C., Liu, Y., Li, C., Li, H., Yang, P., Liu, Y., Hou, F. F., & Zhou, L. (2019). Wnt\/beta-catenin\/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell, 18, e13004.","journal-title":"Aging Cell"},{"key":"9938_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101963","volume":"199","author":"S Song","year":"2021","unstructured":"Song, S., Huang, H., Guan, X., Fiesler, V., Bhuiyan, M. I. H., Liu, R., Jalali, S., Hasan, M. N., Tai, A. K., Chattopadhyay, A., Chaparala, S., Sun, M., Stolz, D. B., He, P., Agalliu, D., Sun, D., & Begum, G. (2021). Activation of endothelial Wnt\/beta-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke. Progress in Neurobiology, 199, 101963.","journal-title":"Progress in Neurobiology"},{"key":"9938_CR23","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1111\/bph.15289","volume":"178","author":"F Zhang","year":"2021","unstructured":"Zhang, F., Wang, F., He, J., Lian, N., Wang, Z., Shao, J., Ding, H., Tan, S., Chen, A., Zhang, Z., Wang, S., & Zheng, S. (2021). Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt\/beta-catenin signalling via interaction with Gli1. British Journal of Pharmacology, 178, 2246\u20132265.","journal-title":"British Journal of Pharmacology"},{"key":"9938_CR24","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.bbadis.2019.01.027","volume":"1865","author":"L Xiao","year":"2019","unstructured":"Xiao, L., Xu, B., Zhou, L., Tan, R. J., Zhou, D., Fu, H., Li, A., Hou, F. F., & Liu, Y. (2019). Wnt\/beta-catenin regulates blood pressure and kidney injury in rats. Biochimica et Biophysica Acta, Molecular Basis of Disease, 1865, 1313\u20131322.","journal-title":"Biochimica et Biophysica Acta, Molecular Basis of Disease"},{"key":"9938_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s12264-018-0297-4","volume":"35","author":"XJ Yu","year":"2019","unstructured":"Yu, X. J., Miao, Y. W., Li, H. B., Su, Q., Liu, K. L., Fu, L. Y., Hou, Y. K., Shi, X. L., Li, Y., Mu, J. J., Chen, W. S., Cui, W., Zhu, G. Q., Ebenezer, P. J., Francis, J., & Kang, Y. M. (2019). Blockade of endogenous angiotensin-(1\u20137) in hypothalamic paraventricular nucleus attenuates high salt-induced sympathoexcitation and hypertension. Neuroscience Bulletin, 35, 47\u201356.","journal-title":"Neuroscience Bulletin"},{"key":"9938_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.756671","volume":"12","author":"Q Su","year":"2021","unstructured":"Su, Q., Yu, X. J., Wang, X. M., Li, H. B., Li, Y., Bai, J., Qi, J., Zhang, N., Liu, K. L., Zhang, Y., Zhu, G. Q., & Kang, Y. M. (2021). Bilateral paraventricular nucleus upregulation of extracellular superoxide dismutase decreases blood pressure by regulation of the NLRP3 and neurotransmitters in salt-induced hypertensive rats. Frontiers in Pharmacology, 12, 756671.","journal-title":"Frontiers in Pharmacology"},{"key":"9938_CR27","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.3390\/nu14194177","volume":"14","author":"J Qi","year":"2022","unstructured":"Qi, J., Fu, L. Y., Liu, K. L., Li, R. J., Qiao, J. A., Yu, X. J., Yu, J. Y., Li, Y., Feng, Z. P., Yi, Q. Y., Jia, H., Gao, H. L., Tan, H., & Kang, Y. M. (2022). Resveratrol in the hypothalamic paraventricular nucleus attenuates hypertension by regulation of ROS and neurotransmitters. Nutrients, 14, 4177.","journal-title":"Nutrients"},{"key":"9938_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.805070","volume":"15","author":"XJ Yu","year":"2021","unstructured":"Yu, X. J., Xiao, T., Liu, X. J., Li, Y., Qi, J., Zhang, N., Fu, L. Y., Liu, K. L., Li, Y., & Kang, Y. M. (2021). Effects of Nrf1 in hypothalamic paraventricular nucleus on regulating the blood pressure during hypertension. Frontiers in Neuroscience, 15, 805070.","journal-title":"Frontiers in Neuroscience"},{"key":"9938_CR29","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1113\/EP087924","volume":"104","author":"JD Moreira","year":"2019","unstructured":"Moreira, J. D., Chaudhary, P., Frame, A. A., Puleo, F., Nist, K. M., Abkin, E. A., Moore, T. L., George, J. C., & Wainford, R. D. (2019). Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Galphai(2) protein-dependent, salt-sensitive hypertension. Experimental Physiology, 104, 1892\u20131910.","journal-title":"Experimental Physiology"},{"key":"9938_CR30","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1093\/ajh\/hpad012","volume":"36","author":"WJ Xia","year":"2023","unstructured":"Xia, W. J., Liu, K. L., Wang, X. M., Yang, Y., Meng, T., Qiao, J. A., Zhang, N., Sun, Y. J., Kang, Y. M., & Yu, X. J. (2023). Hypothalamic paraventricular nucleus hydrogen sulfide exerts antihypertensive effects in spontaneously hypertensive rats via the Nrf2 pathway. American Journal of Hypertension, 36, 306\u2013315.","journal-title":"American Journal of Hypertension"},{"key":"9938_CR31","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/164_2019_298","volume":"258","author":"LD Schurman","year":"2020","unstructured":"Schurman, L. D., Lu, D., Kendall, D. A., Howlett, A. C., & Lichtman, A. H. (2020). Molecular mechanism and cannabinoid pharmacology. Handbook of Experimental Pharmacology, 258, 323\u2013353.","journal-title":"Handbook of Experimental Pharmacology"},{"key":"9938_CR32","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1111\/bph.14168","volume":"176","author":"B Malinowska","year":"2019","unstructured":"Malinowska, B., Toczek, M., Pedzinska-Betiuk, A., & Schlicker, E. (2019). Cannabinoids in arterial, pulmonary and portal hypertension\u2014mechanisms of action and potential therapeutic significance. British Journal of Pharmacology, 176, 1395\u20131411.","journal-title":"British Journal of Pharmacology"},{"key":"9938_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.720734","volume":"12","author":"M Dao","year":"2021","unstructured":"Dao, M., & Francois, H. (2021). Cannabinoid receptor 1 inhibition in chronic kidney disease: A new therapeutic toolbox. Front Endocrinol (Lausanne), 12, 720734.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"9938_CR34","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pharmthera.2018.11.008","volume":"196","author":"P Huang","year":"2019","unstructured":"Huang, P., Yan, R., Zhang, X., Wang, L., Ke, X., & Qu, Y. (2019). Activating Wnt\/beta-catenin signaling pathway for disease therapy: Challenges and opportunities. Pharmacology & Therapeutics, 196, 79\u201390.","journal-title":"Pharmacology & Therapeutics"},{"key":"9938_CR35","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jare.2021.11.011","volume":"40","author":"Q Lei","year":"2022","unstructured":"Lei, Q., Yu, Z., Li, H., Cheng, J., & Wang, Y. (2022). Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt\/beta-catenin pathway. Journal of Advanced Research, 40, 197\u2013206.","journal-title":"Journal of Advanced Research"},{"key":"9938_CR36","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s40265-020-01290-3","volume":"80","author":"Y Zhang","year":"2020","unstructured":"Zhang, Y., He, D., Zhang, W., Xing, Y., Guo, Y., Wang, F., Jia, J., Yan, T., Liu, Y., & Lin, S. (2020). ACE inhibitor benefit to kidney and cardiovascular outcomes for patients with non-dialysis chronic kidney disease stages 3\u20135: A network meta-analysis of randomised clinical trials. Drugs, 80, 797\u2013811.","journal-title":"Drugs"},{"key":"9938_CR37","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1523\/JNEUROSCI.2343-22.2023","volume":"43","author":"H Zhang","year":"2023","unstructured":"Zhang, H., Zhou, J. J., Shao, J. Y., Sheng, Z. F., Wang, J., Zheng, P., Kang, X., Liu, Z., Cheng, Z. J., Kline, D. D., & Li, D. P. (2023). Hypothalamic corticotropin-releasing hormone contributes to hypertension in spontaneously hypertensive rats. Journal of Neuroscience, 43, 4513\u20134524.","journal-title":"Journal of Neuroscience"},{"key":"9938_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2022.170798","volume":"153","author":"HA Raquel","year":"2022","unstructured":"Raquel, H. A., Manica, L. A., Ceroni, A., & Michelini, L. C. (2022). Exercise training improves cardiovascular control in sinoaortic denervated SHR by reducing the elevated angiotensin II and augmenting angiotensin-(1\u20137) availability within autonomic and neuroendocrine PVN nuclei. Peptides, 153, 170798.","journal-title":"Peptides"},{"key":"9938_CR39","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1186\/s12889-023-16466-1","volume":"23","author":"WSR Hasani","year":"2023","unstructured":"Hasani, W. S. R., Muhamad, N. A., Hanis, T. M., Maamor, N. H., Chen, X. W., Omar, M. A., Cheng Kueh, Y., Abd Karim, Z., Hassan, M. R. A., & Musa, K. I. (2023). The global estimate of premature cardiovascular mortality: A systematic review and meta-analysis of age-standardized mortality rate. BMC Public Health, 23, 1561.","journal-title":"BMC Public Health"},{"key":"9938_CR40","first-page":"R299","volume":"325","author":"SM Perego","year":"2023","unstructured":"Perego, S. M., Raquel, H. A., Candido, V. B., Masson, G. S., Martins, M. M., Ceroni, A., & Michelini, L. C. (2023). Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 325, R299\u2013R307.","journal-title":"American Journal of Physiology: Regulatory, Integrative and Comparative Physiology"},{"key":"9938_CR41","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1093\/ajh\/hpab103","volume":"34","author":"K Ware","year":"2021","unstructured":"Ware, K., Yildiz, V., Xiao, M., Medipally, A., Hemminger, J., Scarl, R., Satoskar, A. A., Hebert, L., Ivanov, I., Biederman, L., & Brodsky, S. V. (2021). Hypertension and the kidney: Reduced kidney mass is bad for both normotensive and hypertensive rats. American Journal of Hypertension, 34, 1196\u20131202.","journal-title":"American Journal of Hypertension"},{"key":"9938_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1440-1681.1989.tb02999.x","volume":"15","author":"N Minami","year":"1989","unstructured":"Minami, N., Imai, Y., Munakata, M., Sasaki, S., Sekino, H., Abe, K., & Yoshinaga, K. (1989). Age-related changes in blood pressure, heart rate and baroreflex sensitivity in SHR. Clinical and Experimental Pharmacology and Physiology. Supplement, 15, 85\u201387.","journal-title":"Clinical and Experimental Pharmacology and Physiology. Supplement"},{"key":"9938_CR43","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3390\/nu15030502","volume":"15","author":"HL Gao","year":"2023","unstructured":"Gao, H. L., Yu, X. J., Feng, Y. Q., Yang, Y., Hu, H. B., Zhao, Y. Y., Zhang, J. H., Liu, K. L., Zhang, Y., Fu, L. Y., Li, Y., Qi, J., Qiao, J. A., & Kang, Y. M. (2023). Luteolin attenuates hypertension via inhibiting NF-kappaB-mediated inflammation and PI3K\/Akt signaling pathway in the hypothalamic paraventricular nucleus. Nutrients, 15, 502.","journal-title":"Nutrients"},{"key":"9938_CR44","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/jnc.13776","volume":"139","author":"D Haspula","year":"2016","unstructured":"Haspula, D., & Clark, M. A. (2016). Heterologous regulation of the cannabinoid type 1 receptor by angiotensin II in astrocytes of spontaneously hypertensive rats. Journal of Neurochemistry, 139, 523\u2013536.","journal-title":"Journal of Neurochemistry"},{"key":"9938_CR45","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.tips.2006.12.004","volume":"28","author":"T Harkany","year":"2007","unstructured":"Harkany, T., Guzman, M., Galve-Roperh, I., Berghuis, P., Devi, L. A., & Mackie, K. (2007). The emerging functions of endocannabinoid signaling during CNS development. Trends in Pharmacological Sciences, 28, 83\u201392.","journal-title":"Trends in Pharmacological Sciences"},{"key":"9938_CR46","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1097\/HJH.0000000000001621","volume":"36","author":"GQ Li","year":"2018","unstructured":"Li, G. Q., Wang, Z., Zhao, T., Dai, S. X., Liu, J. M., Jia, B. Z., Zhang, Y., & Li, Q. (2018). Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats. Journal of Hypertension, 36, 801\u2013808.","journal-title":"Journal of Hypertension"},{"key":"9938_CR47","doi-asserted-by":"publisher","first-page":"1157043","DOI":"10.3389\/fphar.2023.1157043","volume":"14","author":"B Ni","year":"2023","unstructured":"Ni, B., Sun, M., Zhao, J., Wang, J., & Cao, Z. (2023). The role of beta-catenin in cardiac diseases. Frontiers in Pharmacology, 14, 1157043.","journal-title":"Frontiers in Pharmacology"},{"key":"9938_CR48","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20222429","author":"Z Chen","year":"2023","unstructured":"Chen, Z., He, S., Lian, S., Shen, Y., Jiang, W., Zhou, L., Zhou, L., & Zhang, X. (2023). The Wnt\/beta-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury. Bioscience Report. https:\/\/doi.org\/10.1042\/BSR20222429"},{"key":"9938_CR49","first-page":"11114","volume":"15","author":"S Wei","year":"2023","unstructured":"Wei, S., Lin, L., Jiang, W., Chen, J., Gong, G., & Sui, D. (2023). Naked cuticle homolog 1 prevents mouse pulmonary arterial hypertension via inhibition of Wnt\/beta-catenin and oxidative stress. Aging (Albany NY), 15, 11114\u201311130.","journal-title":"Aging (Albany NY)"},{"key":"9938_CR50","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cbi.2017.05.025","volume":"273","author":"L Chen","year":"2017","unstructured":"Chen, L., Chen, D. Q., Wang, M., Liu, D., Chen, H., Dou, F., Vaziri, N. D., & Zhao, Y. Y. (2017). Role of RAS\/Wnt\/beta-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy. Chemico-Biological Interactions, 273, 56\u201372.","journal-title":"Chemico-Biological Interactions"},{"key":"9938_CR51","doi-asserted-by":"publisher","first-page":"5282","DOI":"10.1007\/s12035-017-0754-5","volume":"55","author":"SA Bhat","year":"2018","unstructured":"Bhat, S. A., Goel, R., Shukla, S., Shukla, R., & Hanif, K. (2018). Angiotensin receptor blockade by inhibiting glial activation promotes hippocampal neurogenesis via activation of Wnt\/beta-catenin signaling in hypertension. Molecular Neurobiology, 55, 5282\u20135298.","journal-title":"Molecular Neurobiology"},{"key":"9938_CR52","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s12264-019-00460-y","volume":"36","author":"Y Qiu","year":"2020","unstructured":"Qiu, Y., Zheng, F., Ye, C., Chen, A. D., Wang, J. J., Chen, Q., Li, Y. H., Kang, Y. M., & Zhu, G. Q. (2020). Angiotensin type 1 receptors and superoxide anion production in hypothalamic paraventricular nucleus contribute to capsaicin-induced excitatory renal reflex and sympathetic activation. Neuroscience Bulletin, 36, 463\u2013474.","journal-title":"Neuroscience Bulletin"},{"key":"9938_CR53","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/ajh\/hpaa074","volume":"33","author":"Y Hirooka","year":"2020","unstructured":"Hirooka, Y. (2020). Sympathetic activation in hypertension: importance of the central nervous system. American Journal of Hypertension, 33, 914\u2013926.","journal-title":"American Journal of Hypertension"},{"key":"9938_CR54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1097\/WNP.0000000000000633","volume":"37","author":"AM Smolyakova","year":"2020","unstructured":"Smolyakova, A. M., Zagzoog, A., Brandt, A. L., Black, T., Mohamed, K., & Laprairie, R. B. (2020). The endocannabinoid system and synthetic cannabinoids in preclinical models of seizure and epilepsy. Journal of Clinical Neurophysiology, 37, 15\u201327.","journal-title":"Journal of Clinical Neurophysiology"},{"key":"9938_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100337","volume":"15","author":"CH Chang","year":"2021","unstructured":"Chang, C. H., Liu, Y. C., Sun, C. Y., Su, C. L., & Gean, P. W. (2021). Regulation of stress-provoked aggressive behavior using endocannabinoids. Neurobiology Stress, 15, 100337.","journal-title":"Neurobiology Stress"},{"key":"9938_CR56","first-page":"7492","volume":"41","author":"CM Mecca","year":"2021","unstructured":"Mecca, C. M., Chao, D., Yu, G., Feng, Y., Segel, I., Zhang, Z., Rodriguez-Garcia, D. M., Pawela, C. P., Hillard, C. J., Hogan, Q. H., & Pan, B. (2021). Dynamic change of endocannabinoid signaling in the medial prefrontal cortex controls the development of depression after neuropathic pain. Journal of Neuroscience, 41, 7492\u20137508.","journal-title":"Journal of Neuroscience"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-024-09938-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-024-09938-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-024-09938-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:41:48Z","timestamp":1737027708000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-024-09938-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["9938"],"URL":"https:\/\/doi.org\/10.1007\/s12012-024-09938-2","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"10 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The use and care of animals in this study were approved by the Laboratory Animal Management Committee of Xi\u2019an Jiaotong University, Xi\u2019an, China (No. 2022-1116). All procedures complied with the Guide for the Care and Use of Laboratory Animals (NIH publication, 8th edition, 2011).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}