{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:43:36Z","timestamp":1772214216503,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s12012-024-09946-2","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T06:50:32Z","timestamp":1733813432000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ultrasound-Targeted \u03b2-Catenin Gene Therapy Improves the Cardiac Function in Mice After Myocardial Infarction"],"prefix":"10.1007","volume":"25","author":[{"given":"Lei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-he","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-hao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-en","family":"Da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-fu","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"9946_CR1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1377\/hlthaff.2018.05372","volume":"38","author":"DM Cutler","year":"2019","unstructured":"Cutler, D. M., Ghosh, K., Messer, K. L., Raghunathan, T. E., Stewart, S. T., & Rosen, A. B. (2019). Explaining the slowdown in medical spending growth among the elderly, 1999\u20132012. Health Affairs (Millwood), 38, 222\u2013229.","journal-title":"Health Affairs (Millwood)"},{"key":"9946_CR2","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.3390\/cells9081894","volume":"9","author":"SW Tobin","year":"2020","unstructured":"Tobin, S. W., Alibhai, F. J., Weisel, R. D., & Li, R. K. (2020). Considering cause and effect of immune cell aging on cardiac repair after myocardial infarction. Cells, 9, 1894.","journal-title":"Cells"},{"key":"9946_CR3","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.3390\/cells11244050","volume":"11","author":"PJ Ruchaya","year":"2022","unstructured":"Ruchaya, P. J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E., & Ellison-Hughes, G. M. (2022). Transplantation of skeletal muscle-derived Sca-1(+)\/PW1(+)\/Pax7(\u2212) interstitial cells (PICs) improves cardiac function and attenuates remodeling in mice subjected to myocardial infarction. Cells, 11, 4050.","journal-title":"Cells"},{"key":"9946_CR4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/cvr\/cvv205","volume":"108","author":"MY Rincon","year":"2015","unstructured":"Rincon, M. Y., VandenDriessche, T., & Chuah, M. K. (2015). Gene therapy for cardiovascular disease: Advances in vector development, targeting, and delivery for clinical translation. Cardiovascular Research, 108, 4\u201320.","journal-title":"Cardiovascular Research"},{"key":"9946_CR5","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1161\/CIRCRESAHA.111.252981","volume":"110","author":"L Tilemann","year":"2012","unstructured":"Tilemann, L., Ishikawa, K., Weber, T., & Hajjar, R. J. (2012). Gene therapy for heart failure. Circulation Research, 110, 777\u2013793.","journal-title":"Circulation Research"},{"key":"9946_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1089\/humc.2017.070","volume":"28","author":"MG Katz","year":"2017","unstructured":"Katz, M. G., Fargnoli, A. S., Weber, T., Hajjar, R. J., & Bridges, C. R. (2017). Use of adeno-associated virus vector for cardiac gene delivery in large-animal surgical models of heart failure. Human Gene Therapy Clinical Development, 28, 157\u2013164.","journal-title":"Human Gene Therapy Clinical Development"},{"key":"9946_CR7","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.3390\/cells10102571","volume":"10","author":"C Prat-Vidal","year":"2021","unstructured":"Prat-Vidal, C., Crisostomo, V., Moscoso, I., Baez-Diaz, C., Blanco-Blazquez, V., Gomez-Mauricio, G., Albericio, G., Aguilar, S., Fernandez-Santos, M. E., Fernandez-Aviles, F., Sanchez-Margallo, F. M., Bayes-Genis, A., & Bernad, A. (2021). Intracoronary delivery of porcine cardiac progenitor cells overexpressing IGF-1 and HGF in a pig model of sub-acute myocardial infarction. Cells, 10, 2571.","journal-title":"Cells"},{"key":"9946_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3150","volume":"22","author":"YT Le Guen","year":"2020","unstructured":"Le Guen, Y. T., Le Gall, T., Midoux, P., Guegan, P., Braun, S., & Montier, T. (2020). Gene transfer to skeletal muscle using hydrodynamic limb vein injection: Current applications, hurdles and possible optimizations. The Journal of Gene Medicine, 22, e3150.","journal-title":"The Journal of Gene Medicine"},{"key":"9946_CR9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1021\/cr800409e","volume":"109","author":"MA Mintzer","year":"2009","unstructured":"Mintzer, M. A., & Simanek, E. E. (2009). Nonviral vectors for gene delivery. Chemical Reviews, 109, 259\u2013302.","journal-title":"Chemical Reviews"},{"key":"9946_CR10","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.gendis.2016.08.001","volume":"4","author":"J Wu","year":"2017","unstructured":"Wu, J., & Li, R. K. (2017). Ultrasound-targeted microbubble destruction in gene therapy: A new tool to cure human diseases. Genes & Diseases, 4, 64\u201374.","journal-title":"Genes & Diseases"},{"key":"9946_CR11","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.biomaterials.2012.11.041","volume":"34","author":"L Sun","year":"2013","unstructured":"Sun, L., Huang, C. W., Wu, J., Chen, K. J., Li, S. H., Weisel, R. D., Rakowski, H., Sung, H. W., & Li, R. K. (2013). The use of cationic microbubbles to improve ultrasound-targeted gene delivery to the ischemic myocardium. Biomaterials, 34, 2107\u20132116.","journal-title":"Biomaterials"},{"key":"9946_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","volume":"17","author":"BT MacDonald","year":"2009","unstructured":"MacDonald, B. T., Tamai, K., & He, X. (2009). Wnt\/beta-catenin signaling: Components, mechanisms, and diseases. Developmental Cell, 17, 9\u201326.","journal-title":"Developmental Cell"},{"key":"9946_CR13","doi-asserted-by":"publisher","first-page":"9251","DOI":"10.3892\/mmr.2017.7748","volume":"16","author":"L Qiu","year":"2017","unstructured":"Qiu, L., Chen, J., Lin, J., Wo, D., Chu, J., & Peng, J. (2017). Baicalin alleviates H2O2-induced injury of H9c2 cardiomyocytes through suppression of the Wnt\/beta-catenin signaling pathway. Molecular Medicine Reports, 16, 9251\u20139255.","journal-title":"Molecular Medicine Reports"},{"key":"9946_CR14","first-page":"886","volume":"22","author":"Y Wang","year":"2016","unstructured":"Wang, Y., Sang, A., Zhu, M., Zhang, G., Guan, H., Ji, M., & Chen, H. (2016). Tissue factor induces VEGF expression via activation of the Wnt\/beta-catenin signaling pathway in ARPE-19 cells. Molecular Vision, 22, 886\u2013897.","journal-title":"Molecular Vision"},{"key":"9946_CR15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jsbmb.2017.08.014","volume":"174","author":"Y Xiong","year":"2017","unstructured":"Xiong, Y., Zhang, Y., Xin, N., Yuan, Y., Zhang, Q., Gong, P., & Wu, Y. (2017). 1alpha,25-Dihydroxyvitamin D(3) promotes osteogenesis by promoting Wnt signaling pathway. Journal of Steroid Biochemistry and Molecular Biology, 174, 153\u2013160.","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"9946_CR16","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.ijbiomac.2019.11.077","volume":"155","author":"Y Li","year":"2020","unstructured":"Li, Y., Hu, Z., Wang, X., Wu, M., Zhou, H., & Zhang, Y. (2020). Characterization of a polysaccharide with antioxidant and anti-cervical cancer potentials from the corn silk cultivated in Jilin province. International Journal of Biological Macromolecules, 155, 1105\u20131113.","journal-title":"International Journal of Biological Macromolecules"},{"key":"9946_CR17","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1093\/eurheartj\/ehq475","volume":"32","author":"H Fujii","year":"2011","unstructured":"Fujii, H., Li, S. H., Wu, J., Miyagi, Y., Yau, T. M., Rakowski, H., Egashira, K., Guo, J., Weisel, R. D., & Li, R. K. (2011). Repeated and targeted transfer of angiogenic plasmids into the infarcted rat heart via ultrasound targeted microbubble destruction enhances cardiac repair. European Heart Journal, 32, 2075\u20132084.","journal-title":"European Heart Journal"},{"key":"9946_CR18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","volume":"7","author":"J Liu","year":"2022","unstructured":"Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022). Wnt\/beta-catenin signalling: Function, biological mechanisms, and therapeutic opportunities. Signal Transduction and Targeted Therapy, 7, 3.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"9946_CR19","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1007\/s11886-022-01756-8","volume":"24","author":"D Li","year":"2022","unstructured":"Li, D., Sun, J., & Zhong, T. P. (2022). Wnt signaling in heart development and regeneration. Current Cardiology Reports, 24, 1425\u20131438.","journal-title":"Current Cardiology Reports"},{"key":"9946_CR20","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00395-011-0183-y","volume":"106","author":"SK Sanganalmath","year":"2011","unstructured":"Sanganalmath, S. K., Abdel-Latif, A., Bolli, R., Xuan, Y. T., & Dawn, B. (2011). Hematopoietic cytokines for cardiac repair: Mobilization of bone marrow cells and beyond. Basic Research in Cardiology, 106, 709\u2013733.","journal-title":"Basic Research in Cardiology"},{"key":"9946_CR21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cjca.2019.10.011","volume":"36","author":"N Leblanc","year":"2020","unstructured":"Leblanc, N. (2020). Role of the CLC-3 channel transporter in angiogenesis by endothelial progenitor cells in ischemia-induced vascular injury: A key passenger or a driver? Canadian Journal of Cardiology, 36, 154\u2013156.","journal-title":"Canadian Journal of Cardiology"},{"key":"9946_CR22","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1161\/CIRCRESAHA.111.263830","volume":"111","author":"E Yaniz-Galende","year":"2012","unstructured":"Yaniz-Galende, E., Chen, J., Chemaly, E., Liang, L., Hulot, J. S., McCollum, L., Arias, T., Fuster, V., Zsebo, K. M., & Hajjar, R. J. (2012). Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circulation research, 111, 1434\u20131445.","journal-title":"Circulation research"},{"key":"9946_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-020-00063-0","author":"E Fathi","year":"2020","unstructured":"Fathi, E., Farahzadi, R., Vietor, I., & Javanmardi, S. (2020). Cardiac differentiation of bone-marrow-resident c-kit(+) stem cells by L-carnitine increases through secretion of VEGF, IL6, IGF-1, and TGF- \u03b2 as clinical agents in cardiac regeneration. Journal of Biosciences. https:\/\/doi.org\/10.1007\/s12038-020-00063-0","journal-title":"Journal of Biosciences"},{"key":"9946_CR24","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1159\/000480730","volume":"58","author":"C Klopsch","year":"2017","unstructured":"Klopsch, C., Skorska, A., Ludwig, M., Gaebel, R., Lemcke, H., Kleiner, G., Beyer, M., Vollmar, B., David, R., & Steinhoff, G. (2017). Cardiac mesenchymal stem cells proliferate early in the ischemic heart. European Surgical Research, 58, 341\u2013353.","journal-title":"European Surgical Research"},{"key":"9946_CR25","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1161\/CIRCULATIONAHA.105.541268","volume":"113","author":"H Iwasaki","year":"2006","unstructured":"Iwasaki, H., Kawamoto, A., Ishikawa, M., Oyamada, A., Nakamori, S., Nishimura, H., Sadamoto, K., Horii, M., Matsumoto, T., Murasawa, S., Shibata, T., Suehiro, S., & Asahara, T. (2006). Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction. Circulation, 113, 1311\u20131325.","journal-title":"Circulation"},{"key":"9946_CR26","first-page":"1582","volume":"18","author":"L Xu","year":"2018","unstructured":"Xu, L., Jiang, X., Wei, F., & Zhu, H. (2018). Leonurine protects cardiac function following acute myocardial infarction through anti-apoptosis by the PI3K\/AKT\/GSK3beta signaling pathway. Molecular Medicine Reports, 18, 1582\u20131590.","journal-title":"Molecular Medicine Reports"},{"key":"9946_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrm2308","volume":"9","author":"RJ Youle","year":"2008","unstructured":"Youle, R. J., & Strasser, A. (2008). The BCL-2 protein family: Opposing activities that mediate cell death. Nature Reviews Molecular Cell Biology, 9, 47\u201359.","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"9946_CR28","doi-asserted-by":"publisher","first-page":"A81","DOI":"10.1161\/res.117.suppl_1.81","volume":"117","author":"F Xiang","year":"2015","unstructured":"Xiang, F., Fang, M., & Yutzey, K. J. C. R. (2015). Abstract 81: Beta-catenin loss-of-function in cardiac fibroblasts attenuate cardiac fibrosis after transverse aortic constriction in mice. Circulation Research, 117, A81.","journal-title":"Circulation Research"},{"key":"9946_CR29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.yjmcc.2018.08.011","volume":"122","author":"N Froese","year":"2018","unstructured":"Froese, N., Wang, H., Zwadlo, C., Wang, Y., Grund, A., Gigina, A., Hofmann, M., Kilian, K., Scharf, G., Korf-Klingebiel, M., Melchert, A., Signorini, M. E. R., Halloin, C., Zweigerdt, R., Martin, U., Gruh, I., Wollert, K. C., Geffers, R., Bauersachs, J., & Heineke, J. (2018). Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice. Journal of Molecular and Cellular Cardiology, 122, 114\u2013124.","journal-title":"Journal of Molecular and Cellular Cardiology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-024-09946-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-024-09946-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-024-09946-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:50:19Z","timestamp":1737024619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-024-09946-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["9946"],"URL":"https:\/\/doi.org\/10.1007\/s12012-024-09946-2","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,10]]},"assertion":[{"value":"30 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study was approved by the Ethics Committee of the Second Affiliated Hospital of Harbin Medical University (protocol code 2015-research-123 and March 2, 2015). All experiments were carried out according to the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, 8th Edition, 2011), and the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}