{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:55:20Z","timestamp":1780055720736,"version":"3.54.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s12012-024-09950-6","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T14:27:28Z","timestamp":1735309648000},"page":"97-109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["SUZ12-Increased NRF2 Alleviates Cardiac Ischemia\/Reperfusion Injury by Regulating Apoptosis, Inflammation, and Ferroptosis"],"prefix":"10.1007","volume":"25","author":[{"given":"Guoyong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"issue":"18","key":"9950_CR1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.029971","volume":"12","author":"C Krittanawong","year":"2023","unstructured":"Krittanawong, C., Khawaja, M., Tamis-Holland, J. E., Girotra, S., & Rao, S. V. (2023). Acute myocardial infarction: Etiologies and mimickers in young patients. Journal of the American Heart Association, 12(18), e029971.","journal-title":"Journal of the American Heart Association"},{"issue":"2","key":"9950_CR2","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jjcc.2022.07.003","volume":"81","author":"Y Saito","year":"2023","unstructured":"Saito, Y., Oyama, K., Tsujita, K., Yasuda, S., & Kobayashi, Y. (2023). Treatment strategies of acute myocardial infarction: Updates on revascularization, pharmacological therapy, and beyond. Journal of Cardiology, 81(2), 168\u2013178.","journal-title":"Journal of Cardiology"},{"key":"9950_CR3","doi-asserted-by":"publisher","first-page":"5793867","DOI":"10.1155\/2019\/5793867","volume":"2019","author":"ZJ Mao","year":"2019","unstructured":"Mao, Z. J., Lin, H., Hou, J. W., Zhou, Q., Wang, Q., & Chen, Y. H. (2019). A Meta-analysis of resveratrol protects against myocardial ischemia\/reperfusion injury: Evidence from small animal studies and insight into molecular mechanisms. Oxidative Medicine and Cellular Longevity, 2019, 5793867.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"11","key":"9950_CR4","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.2174\/0929867324666170329100619","volume":"25","author":"S Hernandez-Resendiz","year":"2018","unstructured":"Hernandez-Resendiz, S., Chinda, K., Ong, S. B., Cabrera-Fuentes, H., Zazueta, C., & Hausenloy, D. J. (2018). The role of redox dysregulation in the inflammatory response to acute myocardial ischaemia-reperfusion injury-adding fuel to the fire. Current Medicinal Chemistry, 25(11), 1275\u20131293.","journal-title":"Current Medicinal Chemistry"},{"issue":"3","key":"9950_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","volume":"35","author":"Q Xiang","year":"2024","unstructured":"Xiang, Q., Yi, X., Zhu, X. H., Wei, X., & Jiang, D. S. (2024). Regulated cell death in myocardial ischemia-reperfusion injury. Trends in Endocrinology and Metabolism: TEM, 35(3), 219\u2013234.","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"issue":"12","key":"9950_CR6","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/abbs\/gmw104","volume":"48","author":"Y Feng","year":"2016","unstructured":"Feng, Y., Zhao, J., Hou, H., Zhang, H., Jiao, Y., Wang, J., Wang, Y., & Sun, Y. (2016). WDR26 promotes mitophagy of cardiomyocytes induced by hypoxia through Parkin translocation. Acta biochimica et biophysica Sinica, 48(12), 1075\u20131084.","journal-title":"Acta biochimica et biophysica Sinica"},{"issue":"3","key":"9950_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12503","volume":"65","author":"H Zhou","year":"2018","unstructured":"Zhou, H., Li, D., Zhu, P., Ma, Q., Toan, S., Wang, J., Hu, S., Chen, Y., & Zhang, Y. (2018). Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury. Journal of Pineal Research, 65(3), e12503.","journal-title":"Journal of Pineal Research"},{"issue":"2","key":"9950_CR8","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1089\/dna.2019.5097","volume":"39","author":"W Li","year":"2020","unstructured":"Li, W., Li, W., Leng, Y., Xiong, Y., & Xia, Z. (2020). Ferroptosis is involved in diabetes myocardial ischemia\/reperfusion injury through endoplasmic reticulum stress. DNA and Cell Biology, 39(2), 210\u2013225.","journal-title":"DNA and Cell Biology"},{"issue":"1","key":"9950_CR9","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41420-022-01235-7","volume":"8","author":"L Shao","year":"2022","unstructured":"Shao, L., Shen, Y., Ren, C., Kobayashi, S., Asahara, T., & Yang, J. (2022). Inflammation in myocardial infarction: Roles of mesenchymal stem cells and their secretome. Cell Death Discovery, 8(1), 452.","journal-title":"Cell Death Discovery"},{"key":"9950_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102624","volume":"60","author":"MM Alam","year":"2023","unstructured":"Alam, M. M., Kishino, A., Sung, E., Sekine, H., Abe, T., Murakami, S., Akaike, T., & Motohashi, H. (2023). Contribution of NRF2 to sulfur metabolism and mitochondrial activity. Redox Biology, 60, 102624.","journal-title":"Redox Biology"},{"issue":"1","key":"9950_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11418-018-1241-7","volume":"73","author":"G Chen","year":"2019","unstructured":"Chen, G., Liu, G., Cao, D., Jin, M., Guo, D., & Yuan, X. (2019). Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2\/HO-1 signaling. Journal of Natural Medicines, 73(1), 85\u201392.","journal-title":"Journal of Natural Medicines"},{"key":"9950_CR12","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.freeradbiomed.2017.04.027","volume":"108","author":"KJ Bubb","year":"2017","unstructured":"Bubb, K. J., Kok, C., Tang, O., Rasko, N. B., Birgisdottir, A. B., Hansen, T., Ritchie, R., Bhindi, R., Reisman, S. A., Meyer, C., et al. (2017). The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling. Free Radical Biology & Medicine, 108, 585\u2013594.","journal-title":"Free Radical Biology & Medicine"},{"key":"9950_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.taap.2017.03.025","volume":"327","author":"J Strom","year":"2017","unstructured":"Strom, J., & Chen, Q. M. (2017). Loss of Nrf2 promotes rapid progression to heart failure following myocardial infarction. Toxicology and Applied Pharmacology, 327, 52\u201358.","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9950_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.967193","volume":"13","author":"L Wang","year":"2022","unstructured":"Wang, L., & He, C. (2022). Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis. Frontiers in Immunology, 13, 967193.","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"9950_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2174\/1570180818666210413131108","volume":"19","author":"A Onunkun Toritseju","year":"2022","unstructured":"Onunkun Toritseju, A., Iwaloye, O., & Elekofehinti Olalekan, O. (2022). Identification of novel Nrf2 activator <i>via<\/i> protein-ligand interactions as remedy for oxidative stress in diabetes mellitus. Letters in Drug Design & Discovery, 19(2), 79\u201391.","journal-title":"Letters in Drug Design & Discovery"},{"issue":"1","key":"9950_CR16","first-page":"541","volume":"41","author":"LG Chen","year":"2018","unstructured":"Chen, L. G., Zhang, Y. Q., Wu, Z. Z., Hsieh, C. W., Chu, C. S., & Wung, B. S. (2018). Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-\u03b1-induced ICAM-1 expression and NF-\u03baB activation in endothelial cells. International Journal of Molecular Medicine, 41(1), 541\u2013547.","journal-title":"International Journal of Molecular Medicine"},{"issue":"7","key":"9950_CR17","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","volume":"19","author":"JP Friedmann Angeli","year":"2019","unstructured":"Friedmann Angeli, J. P., Krysko, D. V., & Conrad, M. (2019). Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nature Reviews Cancer, 19(7), 405\u2013414.","journal-title":"Nature Reviews Cancer"},{"issue":"6","key":"9950_CR18","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1111\/ajt.15773","volume":"20","author":"N Yamada","year":"2020","unstructured":"Yamada, N., Karasawa, T., Wakiya, T., Sadatomo, A., Ito, H., Kamata, R., Watanabe, S., Komada, T., Kimura, H., Sanada, Y., et al. (2020). Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: Potential role of ferroptosis. American Journal of Transplantation, 20(6), 1606\u20131618.","journal-title":"American Journal of Transplantation"},{"issue":"1","key":"9950_CR19","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41420-022-01173-4","volume":"8","author":"T Zhao","year":"2022","unstructured":"Zhao, T., Yu, Z., Zhou, L., Wang, X., Hui, Y., Mao, L., Fan, X., Wang, B., Zhao, X., & Sun, C. (2022). Regulating Nrf2-GPx4 axis by bicyclol can prevent ferroptosis in carbon tetrachloride-induced acute liver injury in mice. Cell Death Discovery, 8(1), 380.","journal-title":"Cell Death Discovery"},{"key":"9950_CR20","first-page":"3192607","volume":"2022","author":"X Liu","year":"2022","unstructured":"Liu, X., Chen, C., Han, D., Zhou, W., Cui, Y., Tang, X., Xiao, C., Wang, Y., & Gao, Y. (2022). SLC7A11\/GPX4 inactivation-mediated ferroptosis contributes to the pathogenesis of triptolide-induced cardiotoxicity. Oxidative Medicine and Cellular Longevity, 2022, 3192607.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"7330","key":"9950_CR21","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature09784","volume":"469","author":"R Margueron","year":"2011","unstructured":"Margueron, R., & Reinberg, D. (2011). The polycomb complex PRC2 and its mark in life. Nature, 469(7330), 343\u2013349.","journal-title":"Nature"},{"issue":"12","key":"9950_CR22","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nrc.2016.83","volume":"16","author":"I Comet","year":"2016","unstructured":"Comet, I., Riising, E. M., Leblanc, B., & Helin, K. (2016). Maintaining cell identity: PRC2-mediated regulation of transcription and cancer. Nature Reviews Cancer, 16(12), 803\u2013810.","journal-title":"Nature Reviews Cancer"},{"issue":"1","key":"9950_CR23","doi-asserted-by":"publisher","first-page":"6781","DOI":"10.1038\/s41467-022-34431-1","volume":"13","author":"L Gong","year":"2022","unstructured":"Gong, L., Liu, X., Jiao, L., Yang, X., Lemoff, A., & Liu, X. (2022). CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site. Nature Communications, 13(1), 6781.","journal-title":"Nature Communications"},{"key":"9950_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainresbull.2021.05.003","volume":"173","author":"M Sawahata","year":"2021","unstructured":"Sawahata, M., Izumi, Y., Akaike, A., & Kume, T. (2021). In vivo brain ischemia-reperfusion model induced by hypoxia-reoxygenation using zebrafish larvae. Brain Research Bulletin, 173, 45\u201352.","journal-title":"Brain Research Bulletin"},{"issue":"3","key":"9950_CR25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s40883-018-0056-0","volume":"4","author":"T Chen","year":"2018","unstructured":"Chen, T., & Vunjak-Novakovic, G. (2018). In vitro models of ischemia-reperfusion injury. Regenerative Engineering and Translational Medicine, 4(3), 142\u2013153.","journal-title":"Regenerative Engineering and Translational Medicine"},{"issue":"12","key":"9950_CR26","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.2174\/0115701808235958230923042422","volume":"21","author":"J Hong","year":"2024","unstructured":"Hong, J., Ye, Y., Zheng, D., & Qian, X. (2024). Kukoamine a activates Akt\/GSK-3\u03b2 pathway to repress oxidative stress and inflammation to alleviate myocardial ischemia-reperfusion injury. Letters in Drug Design & Discovery, 21(12), 2374\u20132383.","journal-title":"Letters in Drug Design & Discovery"},{"key":"9950_CR27","doi-asserted-by":"publisher","first-page":"113572","DOI":"10.1016\/j.biopha.2022.113572","volume":"154","author":"Z Wang","year":"2022","unstructured":"Wang, Z., Yao, M., Jiang, L., Wang, L., Yang, Y., Wang, Q., Qian, X., Zhao, Y., & Qian, J. (2022). Dexmedetomidine attenuates myocardial ischemia\/reperfusion-induced ferroptosis via AMPK\/GSK-3\u03b2\/Nrf2 axis. Biomedicine & Pharmacotherapy, 154, 113572.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"9950_CR28","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.freeradbiomed.2022.08.016","volume":"190","author":"H Yao","year":"2022","unstructured":"Yao, H., He, Q., Huang, C., Wei, S., Gong, Y., Li, X., Liu, W., Xu, Z., Wu, H., Zheng, C., et al. (2022). Panaxatriol saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1\/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation. Free Radical Biology & Medicine, 190, 264\u2013275.","journal-title":"Free Radical Biology & Medicine"},{"issue":"1","key":"9950_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.7150\/ijbs.37269","volume":"16","author":"S Xie","year":"2020","unstructured":"Xie, S., Deng, W., Chen, J., Wu, Q. Q., Li, H., Wang, J., Wei, L., Liu, C., Duan, M., Cai, Z., et al. (2020). Andrographolide protects against adverse cardiac remodeling after myocardial infarction through enhancing Nrf2 signaling pathway. International Journal of Biological Sciences, 16(1), 12\u201326.","journal-title":"International Journal of Biological Sciences"},{"issue":"11","key":"9950_CR30","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1093\/jpp\/rgad080","volume":"75","author":"YT Wu","year":"2023","unstructured":"Wu, Y. T., Zhang, G. Y., Hua, Y., Fan, H. J., Han, X., Xu, H. L., Chen, G. H., Liu, B., Xie, L. P., & Zhou, Y. C. (2023). Ferrostatin-1 suppresses cardiomyocyte ferroptosis after myocardial infarction by activating Nrf2 signaling. The Journal of Pharmacy and Pharmacology, 75(11), 1467\u20131477.","journal-title":"The Journal of Pharmacy and Pharmacology"},{"issue":"7","key":"9950_CR31","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23365","volume":"37","author":"L Guo","year":"2023","unstructured":"Guo, L., & Zhang, C. (2023). SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs. Journal of Biochemical and Molecular Toxicology, 37(7), e23365.","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"issue":"2","key":"9950_CR32","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.tranon.2018.01.009","volume":"11","author":"J Hu","year":"2018","unstructured":"Hu, J., Su, P., Jiao, M., Bai, X., Qi, M., Liu, H., Wu, Z., Sun, J., Zhou, G., & Han, B. (2018). TRPS1 suppresses breast cancer epithelial-mesenchymal transition program as a negative regulator of SUZ12. Translational Oncology, 11(2), 416\u2013425.","journal-title":"Translational Oncology"},{"issue":"1","key":"9950_CR33","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13046-023-02932-6","volume":"43","author":"W Wei","year":"2024","unstructured":"Wei, W., Liu, K., Huang, X., Tian, S., Wang, H., Zhang, C., Ye, J., Dong, Y., An, Z., Ma, X., et al. (2024). EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance. Journal of Experimental & Clinical Cancer Research\u202f: CR, 43(1), 2.","journal-title":"Journal of Experimental & Clinical Cancer Research : CR"},{"key":"9950_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.852775","volume":"9","author":"Y Han","year":"2022","unstructured":"Han, Y., Du, T., Guo, S., Wang, L., Dai, G., Long, T., Xu, T., Zhuang, X., Liu, C., Li, S., et al. (2022). Loss of m(6)A methyltransferase METTL5 promotes cardiac hypertrophy through epitranscriptomic control of SUZ12 expression. Frontiers in Cardiovascular Medicine, 9, 852775.","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"1","key":"9950_CR35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006525","volume":"13","author":"J Yu","year":"2020","unstructured":"Yu, J., Yang, Y., Xu, Z., Lan, C., Chen, C., Li, C., Chen, Z., Yu, C., Xia, X., Liao, Q., et al. (2020). Long noncoding RNA Ahit protects against cardiac hypertrophy through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-mediated downregulation of MEF2A (Myocyte Enhancer Factor 2A). Circulation Heart Failure, 13(1), e006525.","journal-title":"Circulation Heart Failure"},{"issue":"6","key":"9950_CR36","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1536\/ihj.22-452","volume":"64","author":"L Li","year":"2023","unstructured":"Li, L., Li, C., Cao, S., Zhou, G., Jiang, Y., & Feng, J. (2023). Circ-SUZ12 protects cardiomyocytes from hypoxia-induced dysfunction through upregulating SUZ12 expression to activate Wnt\/\u03b2-catenin signaling pathway. International Heart Journal, 64(6), 1113\u20131124.","journal-title":"International Heart Journal"},{"issue":"10229","key":"9950_CR37","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/S0140-6736(20)30164-1","volume":"395","author":"PL Bedard","year":"2020","unstructured":"Bedard, P. L., Hyman, D. M., Davids, M. S., & Siu, L. L. (2020). Small molecules, big impact: 20 years of targeted therapy in oncology. Lancet (London, England), 395(10229), 1078\u20131088.","journal-title":"Lancet (London, England)"},{"issue":"4","key":"9950_CR38","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3390\/pharmaceutics16040461","volume":"16","author":"R Dankar","year":"2024","unstructured":"Dankar, R., Wehbi, J., & Refaat, M. M. (2024). Tailoring treatment in cardiovascular diseases: The role of targeted therapies. Pharmaceutics, 16(4), 461.","journal-title":"Pharmaceutics"},{"issue":"6","key":"9950_CR39","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/ccd.24555","volume":"82","author":"L Favaloro","year":"2013","unstructured":"Favaloro, L., Diez, M., Mendiz, O., Janavel, G. V., Valdivieso, L., Ratto, R., Garelli, G., Salmo, F., Criscuolo, M., Bercovich, A., et al. (2013). High-dose plasmid-mediated VEGF gene transfer is safe in patients with severe ischemic heart disease (Genesis-I). A phase I, open-label, two-year follow-up trial. Catheterization and Cardiovascular Interventions., 82(6), 899\u2013906.","journal-title":"Catheterization and Cardiovascular Interventions."},{"issue":"9","key":"9950_CR40","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1021\/acs.accounts.9b00368","volume":"52","author":"JA Kulkarni","year":"2019","unstructured":"Kulkarni, J. A., Witzigmann, D., Chen, S., Cullis, P. R., & van der Meel, R. (2019). Lipid nanoparticle technology for clinical translation of siRNA therapeutics. Accounts of Chemical Research, 52(9), 2435\u20132444.","journal-title":"Accounts of Chemical Research"},{"key":"9950_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.623674","volume":"12","author":"M Xu","year":"2021","unstructured":"Xu, M., & Song, J. (2021). Targeted therapy in cardiovascular disease: A precision therapy era. Frontiers in Pharmacology, 12, 623674.","journal-title":"Frontiers in Pharmacology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-024-09950-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-024-09950-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-024-09950-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:41:32Z","timestamp":1737027692000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-024-09950-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["9950"],"URL":"https:\/\/doi.org\/10.1007\/s12012-024-09950-6","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,27]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Written informed consents were obtained from all participants and this study was permitted by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}