{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:54:45Z","timestamp":1775004885596,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30ES030283"],"award-info":[{"award-number":["P30ES030283"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P42ES023716"],"award-info":[{"award-number":["P42ES023716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM127607"],"award-info":[{"award-number":["P20GM127607"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC7AI180309-01"],"award-info":[{"award-number":["UC7AI180309-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32ES011564"],"award-info":[{"award-number":["T32ES011564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T35ES014559"],"award-info":[{"award-number":["T35ES014559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL122676"],"award-info":[{"award-number":["HL122676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL1493513"],"award-info":[{"award-number":["HL1493513"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54HL120163"],"award-info":[{"award-number":["U54HL120163"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL171763"],"award-info":[{"award-number":["HL171763"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30ES030283"],"award-info":[{"award-number":["P30ES030283"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P42ES023716"],"award-info":[{"award-number":["P42ES023716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM127607"],"award-info":[{"award-number":["P20GM127607"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC7AI180309-01"],"award-info":[{"award-number":["UC7AI180309-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32ES011564"],"award-info":[{"award-number":["T32ES011564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T35ES014559"],"award-info":[{"award-number":["T35ES014559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL122676"],"award-info":[{"award-number":["HL122676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL149351"],"award-info":[{"award-number":["HL149351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54HL120163"],"award-info":[{"award-number":["U54HL120163"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL171763"],"award-info":[{"award-number":["HL171763"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["HT94252410596"],"award-info":[{"award-number":["HT94252410596"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s12012-025-09978-2","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T19:43:25Z","timestamp":1740512605000},"page":"523-540","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of the Transient Receptor Potential Ankyrin-1 in the Pulmonary, Vascular, and Systemic Effects of Short-Term Acrolein Inhalation in Mice: Implications for the Toxicity of Electronic Nicotine Delivery Systems"],"prefix":"10.1007","volume":"25","author":[{"given":"Lexiao","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Sithu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Lorkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shweta","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Conklin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"9978_CR1","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1161\/CIRCULATIONAHA.121.057369","volume":"145","author":"JB Berlowitz","year":"2022","unstructured":"Berlowitz, J. B., Xie, W., Harlow, A. F., Hamburg, N. M., Blaha, M. J., Bhatnagar, A., Benjamin, E. J., & Stokes, A. C. (2022). E-cigarette use and risk of cardiovascular disease: A longitudinal analysis of the PATH Study (2013\u20132019). Circulation, 145, 1557\u20131559. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.121.057369","journal-title":"Circulation"},{"key":"9978_CR2","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.cjca.2020.12.008","volume":"37","author":"A Nayeri","year":"2021","unstructured":"Nayeri, A., & Middlekauff, H. (2021). Vaping instead of cigarette smoking: A panacea or just another form of cardiovascular risk? Canadian Journal of Cardiology, 37, 690\u2013698. https:\/\/doi.org\/10.1016\/j.cjca.2020.12.008","journal-title":"Canadian Journal of Cardiology"},{"key":"9978_CR3","doi-asserted-by":"publisher","first-page":"e014570","DOI":"10.1161\/JAHA.119.014570","volume":"9","author":"JL Fetterman","year":"2020","unstructured":"Fetterman, J. L., Keith, R. J., Palmisano, J. N., McGlasson, K. L., Weisbrod, R. M., Majid, S., Bastin, R., Stathos, M. M., Stokes, A. C., Robertson, R. M., et al. (2020). Alterations in vascular function associated with the use of combustible and electronic cigarettes. Journal of the American Heart Association, 9, e014570. https:\/\/doi.org\/10.1161\/JAHA.119.014570","journal-title":"Journal of the American Heart Association"},{"key":"9978_CR4","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.chest.2016.04.012","volume":"150","author":"R Carnevale","year":"2016","unstructured":"Carnevale, R., Sciarretta, S., Violi, F., Nocella, C., Loffredo, L., Perri, L., Peruzzi, M., Marullo, A. G., De Falco, E., Chimenti, I., et al. (2016). Acute impact of tobacco vs electronic cigarette smoking on oxidative stress and vascular function. Chest, 150, 606\u2013612. https:\/\/doi.org\/10.1016\/j.chest.2016.04.012","journal-title":"Chest"},{"key":"9978_CR5","doi-asserted-by":"publisher","first-page":"H547","DOI":"10.1152\/ajpheart.00307.2020","volume":"319","author":"KP Haptonstall","year":"2020","unstructured":"Haptonstall, K. P., Choroomi, Y., Moheimani, R., Nguyen, K., Tran, E., Lakhani, K., Ruedisueli, I., Gornbein, J., & Middlekauff, H. R. (2020). Differential effects of tobacco cigarettes and electronic cigarettes on endothelial function in healthy young people. American Journal of Physiology. Heart and Circulatory Physiology, 319, H547\u2013H556. https:\/\/doi.org\/10.1152\/ajpheart.00307.2020","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9978_CR6","doi-asserted-by":"publisher","first-page":"H801","DOI":"10.1152\/ajpheart.00591.2018","volume":"316","author":"DJ Conklin","year":"2019","unstructured":"Conklin, D. J., Schick, S., Blaha, M. J., Carll, A., DeFilippis, A., Ganz, P., Hall, M. E., Hamburg, N., O\u2019Toole, T., Reynolds, L., et al. (2019). Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. American Journal of Physiology-Heart and Circulatory Physiology, 316, H801\u2013H827. https:\/\/doi.org\/10.1152\/ajpheart.00591.2018","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"9978_CR7","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1093\/ntr\/ntac019","volume":"24","author":"P Rao","year":"2022","unstructured":"Rao, P., Han, D. D., Tan, K., Mohammadi, L., Derakhshandeh, R., Navabzadeh, M., Goyal, N., & Springer, M. L. (2022). Comparable impairment of vascular endothelial function by a wide range of electronic nicotine delivery devices. Nicotine & Tobacco Research, 24, 1055\u20131062. https:\/\/doi.org\/10.1093\/ntr\/ntac019","journal-title":"Nicotine & Tobacco Research"},{"key":"9978_CR8","doi-asserted-by":"publisher","first-page":"30","DOI":"10.18001\/TRS.6.1.4","volume":"6","author":"P Rao","year":"2020","unstructured":"Rao, P., Liu, J., & Springer, M. L. (2020). JUUL and combusted cigarettes comparably impair endothelial function. Tobacco Regulatory Science, 6, 30\u201337. https:\/\/doi.org\/10.18001\/TRS.6.1.4","journal-title":"Tobacco Regulatory Science"},{"key":"9978_CR9","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.amjcard.2018.07.029","volume":"122","author":"C Nocella","year":"2018","unstructured":"Nocella, C., Biondi-Zoccai, G., Sciarretta, S., Peruzzi, M., Pagano, F., Loffredo, L., Pignatelli, P., Bullen, C., Frati, G., & Carnevale, R. (2018). Impact of tobacco versus electronic cigarette smoking on platelet function. American Journal of Cardiology, 122, 1477\u20131481. https:\/\/doi.org\/10.1016\/j.amjcard.2018.07.029","journal-title":"American Journal of Cardiology"},{"key":"9978_CR10","doi-asserted-by":"publisher","unstructured":"Qasim H, Karim ZA, Silva-Espinoza JC, Khasawneh FT, Rivera JO, Ellis CC, Bauer SL, Almeida IC, Alshbool FZ. Short-term e-cigarette exposure increases the risk of thrombogenesis and enhances platelet function in mice. J Am Heart Assoc. 2018;7. https:\/\/doi.org\/10.1161\/JAHA.118.009264","DOI":"10.1161\/JAHA.118.009264"},{"key":"9978_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfae096","author":"L Jin","year":"2024","unstructured":"Jin, L., Richardson, A., Lynch, J., Lorkiewicz, P., Srivastava, S., Fryar, L., Miller, A., Theis, W., Shirk, G., Bhatnagar, A., et al. (2024). Formaldehyde and the transient receptor potential ankyrin-1 contribute to electronic cigarette aerosol-induced endothelial dysfunction in mice. Toxicological Sciences. https:\/\/doi.org\/10.1093\/toxsci\/kfae096","journal-title":"Toxicological Sciences"},{"key":"9978_CR12","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1161\/ATVBAHA.122.318051","volume":"42","author":"P Nabavizadeh","year":"2022","unstructured":"Nabavizadeh, P., Liu, J., Rao, P., Ibrahim, S., Han, D. D., Derakhshandeh, R., Qiu, H., Wang, X., Glantz, S. A., Schick, S. F., et al. (2022). Impairment of endothelial function by cigarette smoke is not caused by a specific smoke constituent, but by vagal input from the airway. Arteriosclerosis, Thrombosis, and Vascular Biology, 42, 1324\u20131332. https:\/\/doi.org\/10.1161\/ATVBAHA.122.318051","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9978_CR13","first-page":"490","volume-title":"Cardiovascular toxicology","author":"DJ Conklin","year":"2010","unstructured":"Conklin, D. J., & Bhatnagar, A. (2010). Aldehydes and cardiovascular disease. In M. Walker & M. Campen (Eds.), Cardiovascular toxicology (pp. 490\u2013512). Elsevier."},{"key":"9978_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.chroma.2003.08.104","volume":"1027","author":"JZ Dong","year":"2004","unstructured":"Dong, J. Z., & Moldoveanu, S. C. (2004). Gas chromatography-mass spectrometry of carbonyl compounds in cigarette mainstream smoke after derivatization with 2,4-dinitrophenylhydrazine. Journal of Chromatography A, 1027, 25\u201335.","journal-title":"Journal of Chromatography A"},{"key":"9978_CR15","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.toxrep.2019.02.009","volume":"6","author":"G Jaccard","year":"2019","unstructured":"Jaccard, G., Djoko, D. T., Korneliou, A., Stabbert, R., Belushkin, M., & Esposito, M. (2019). Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes. Toxicology Reports, 6, 222\u2013231. https:\/\/doi.org\/10.1016\/j.toxrep.2019.02.009","journal-title":"Toxicology Reports"},{"key":"9978_CR16","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1093\/ntr\/ntu078","volume":"16","author":"L Kosmider","year":"2014","unstructured":"Kosmider, L., Sobczak, A., Fik, M., Knysak, J., Zaciera, M., Kurek, J., & Goniewicz, M. L. (2014). Carbonyl compounds in electronic cigarette vapors: Effects of nicotine solvent and battery output voltage. Nicotine & Tobacco Research, 16, 1319\u20131326. https:\/\/doi.org\/10.1093\/ntr\/ntu078","journal-title":"Nicotine & Tobacco Research"},{"key":"9978_CR17","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.ijheh.2016.01.004","volume":"219","author":"O Geiss","year":"2016","unstructured":"Geiss, O., Bianchi, I., & Barrero-Moreno, J. (2016). Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours. International Journal of Hygiene and Environmental Health., 219, 268\u2013277. https:\/\/doi.org\/10.1016\/j.ijheh.2016.01.004","journal-title":"International Journal of Hygiene and Environmental Health."},{"key":"9978_CR18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.yrtph.2015.12.019","volume":"75","author":"IG Gillman","year":"2016","unstructured":"Gillman, I. G., Kistler, K. A., Stewart, E. W., & Paolantonio, A. R. (2016). Effect of variable power levels on the yield of total aerosol mass and formation of aldehydes in e-cigarette aerosols. Regulatory Toxicology and Pharmacology, 75, 58\u201365. https:\/\/doi.org\/10.1016\/j.yrtph.2015.12.019","journal-title":"Regulatory Toxicology and Pharmacology"},{"key":"9978_CR19","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/ntr\/ntu174","volume":"17","author":"S Talih","year":"2015","unstructured":"Talih, S., Balhas, Z., Eissenberg, T., Salman, R., Karaoghlanian, N., El Hellani, A., Baalbaki, R., Saliba, N., & Shihadeh, A. (2015). Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: Measurements and model predictions. Nicotine & Tobacco Research, 17, 150\u2013157. https:\/\/doi.org\/10.1093\/ntr\/ntu174","journal-title":"Nicotine & Tobacco Research"},{"key":"9978_CR20","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1021\/acsomega.6b00489","volume":"2","author":"MA Ogunwale","year":"2017","unstructured":"Ogunwale, M. A., Li, M., Ramakrishnam Raju, M. V., Chen, Y., Nantz, M. H., Conklin, D. J., & Fu, X.-A. (2017). Aldehyde detection in electronic cigarette aerosols. ACS Omega, 2, 1207\u20131214. https:\/\/doi.org\/10.1021\/acsomega.6b00489","journal-title":"ACS Omega"},{"key":"9978_CR21","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1021\/tx200536w","volume":"25","author":"HJ Haussmann","year":"2012","unstructured":"Haussmann, H. J. (2012). Use of hazard indices for a theoretical evaluation of cigarette smoke composition. Chemical Research in Toxicology, 25, 794\u2013810. https:\/\/doi.org\/10.1021\/tx200536w","journal-title":"Chemical Research in Toxicology"},{"key":"9978_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s11906-020-01085-7","volume":"22","author":"J Lynch","year":"2020","unstructured":"Lynch, J., Jin, L., Richardson, A., & Conklin, D. J. (2020). Tobacco smoke and endothelial dysfunction: Role of aldehydes? Current Hypertension Reports, 22, 73. https:\/\/doi.org\/10.1007\/s11906-020-01085-7","journal-title":"Current Hypertension Reports"},{"key":"9978_CR23","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.taap.2010.07.013","volume":"248","author":"SD Sithu","year":"2010","unstructured":"Sithu, S. D., Srivastava, S., Siddiqui, M. A., Vladykovskaya, E., Riggs, D. W., Conklin, D. J., Haberzettl, P., O\u2019Toole, T. E., Bhatnagar, A., & D\u2019Souza, S. E. (2010). Exposure to acrolein by inhalation causes platelet activation. Toxicology and Applied Pharmacology, 248, 100\u2013110. https:\/\/doi.org\/10.1016\/j.taap.2010.07.013","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9978_CR24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/toxsci\/kfx095","volume":"158","author":"DJ Conklin","year":"2017","unstructured":"Conklin, D. J., Malovichko, M. V., Zeller, I., Das, T. P., Krivokhizhina, T. V., Lynch, B. H., Lorkiewicz, P., Agarwal, A., Wickramasinghe, N., Haberzettl, P., et al. (2017). Biomarkers of chronic acrolein inhalation exposure in mice: Implications for tobacco product-induced toxicity. Toxicological Sciences, 158, 263\u2013274. https:\/\/doi.org\/10.1093\/toxsci\/kfx095","journal-title":"Toxicological Sciences"},{"key":"9978_CR25","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1161\/ATVBAHA.111.227124","volume":"31","author":"LA Wheat","year":"2011","unstructured":"Wheat, L. A., Haberzettl, P., Hellmann, J., Baba, S. P., Bertke, M., Lee, J., McCracken, J., O\u2019Toole, T. E., Bhatnagar, A., & Conklin, D. J. (2011). Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+\/Sca-1+ cells in mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 1598\u20131606. https:\/\/doi.org\/10.1161\/ATVBAHA.111.227124","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9978_CR26","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.000934","author":"N DeJarnett","year":"2014","unstructured":"DeJarnett, N., Conklin, D. J., Riggs, D. W., Myers, J. A., O\u2019Toole, T. E., Hamzeh, I., Wagner, S., Chugh, A., Ramos, K. S., Srivastava, S., et al. (2014). Acrolein exposure is associated with increased cardiovascular disease risk. Journal of American Heart Association. https:\/\/doi.org\/10.1161\/JAHA.114.000934","journal-title":"Journal of American Heart Association"},{"key":"9978_CR27","doi-asserted-by":"publisher","first-page":"115647","DOI":"10.1016\/j.taap.2021.115647","volume":"426","author":"L Jin","year":"2021","unstructured":"Jin, L., Lorkiewicz, P., Xie, Z., Bhatnagar, A., Srivastava, S., & Conklin, D. J. (2021). Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicology and Applied Pharmacology, 426, 115647. https:\/\/doi.org\/10.1016\/j.taap.2021.115647","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9978_CR28","doi-asserted-by":"publisher","first-page":"H1586","DOI":"10.1152\/ajpheart.00867.2008","volume":"296","author":"DJ Conklin","year":"2009","unstructured":"Conklin, D. J., Haberzettl, P., Prough, R. A., & Bhatnagar, A. (2009). Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. American Journal of Physiology. Heart and Circulatory Physiology, 296, H1586\u2013H1597.","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9978_CR29","doi-asserted-by":"publisher","first-page":"H1510","DOI":"10.1152\/ajpheart.00878.2020","volume":"320","author":"L Jin","year":"2021","unstructured":"Jin, L., Lynch, J., Richardson, A., Lorkiewicz, P., Srivastava, S., Theis, W., Shirk, G., Hand, A., Bhatnagar, A., Srivastava, S., et al. (2021). Electronic cigarette solvents, pulmonary irritation, and endothelial dysfunction: Role of acetaldehyde and formaldehyde. American Journal of Physiology. Heart and Circulatory Physiology, 320, H1510\u2013H1525. https:\/\/doi.org\/10.1152\/ajpheart.00878.2020","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"9978_CR30","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","volume":"124","author":"DM Bautista","year":"2006","unstructured":"Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., & Julius, D. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell, 124, 1269\u20131282.","journal-title":"Cell"},{"key":"9978_CR31","first-page":"360","volume":"23","author":"BF Bessac","year":"2008","unstructured":"Bessac, B. F., & Jordt, S. E. (2008). Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda, Md.), 23, 360\u2013370.","journal-title":"Physiology (Bethesda, Md.)"},{"key":"9978_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.taap.2016.08.028","volume":"324","author":"DJ Conklin","year":"2017","unstructured":"Conklin, D. J., Haberzettl, P., Jagatheesan, G., Kong, M., & Hoyle, G. W. (2017). Role of TRPA1 in acute cardiopulmonary toxicity of inhaled acrolein. Toxicology and Applied Pharmacology, 324, 61\u201372. https:\/\/doi.org\/10.1016\/j.taap.2016.08.028","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9978_CR33","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1289\/ehp.1003200","volume":"119","author":"MS Hazari","year":"2011","unstructured":"Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Krantz, Q. T., King, C., Costa, D. L., & Farraj, A. K. (2011). TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust. Environmental Health Perspectives, 119, 951\u2013957. https:\/\/doi.org\/10.1289\/ehp.1003200","journal-title":"Environmental Health Perspectives"},{"key":"9978_CR34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1093\/toxsci\/kfy262","volume":"167","author":"LC Thompson","year":"2019","unstructured":"Thompson, L. C., Walsh, L., Martin, B. L., McGee, J., Wood, C., Kovalcik, K., Pancras, J. P., Haykal-Coates, N., Ledbetter, A. D., Davies, D., et al. (2019). Ambient particulate matter and acrolein co-exposure increases myocardial dyssynchrony in mice via TRPA1. Toxicological Sciences, 167, 559\u2013572. https:\/\/doi.org\/10.1093\/toxsci\/kfy262","journal-title":"Toxicological Sciences"},{"key":"9978_CR35","first-page":"2574","volume":"118","author":"E Andre","year":"2008","unstructured":"Andre, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., et al. (2008). Cigarette smoke-induced neurogenic inflammation is mediated by alpha, beta-unsaturated aldehydes and the TRPA1 receptor in rodents. JClinInvest, 118, 2574\u20132582.","journal-title":"JClinInvest"},{"key":"9978_CR36","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1080\/02786826.2018.1500013","volume":"52","author":"DJ Conklin","year":"2018","unstructured":"Conklin, D. J., Ogunwale, M. A., Chen, Y., Theis, W. S., Nantz, M. H., Fu, X. A., Chen, L. C., Riggs, D. W., Lorkiewicz, P., Bhatnagar, A., et al. (2018). Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Science and Technology, 52, 1219\u20131232. https:\/\/doi.org\/10.1080\/02786826.2018.1500013","journal-title":"Aerosol Science and Technology"},{"key":"9978_CR37","doi-asserted-by":"publisher","first-page":"115120","DOI":"10.1016\/j.taap.2020.115120","volume":"402","author":"J Lynch","year":"2020","unstructured":"Lynch, J., Jin, L., Richardson, A., Jagatheesan, G., Lorkiewicz, P., Xie, Z., Theis, W. S., Shirk, G., Malovichko, M. V., Bhatnagar, A., et al. (2020). Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1. Toxicology and Applied Pharmacology., 402, 115120. https:\/\/doi.org\/10.1016\/j.taap.2020.115120","journal-title":"Toxicology and Applied Pharmacology."},{"key":"9978_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jchromb.2018.09.012","volume":"1099","author":"Z Xie","year":"2018","unstructured":"Xie, Z., Lorkiewicz, P., Riggs, D. W., Bhatnagar, A., & Srivastava, S. (2018). Comprehensive, robust, and sensitive UPLC-MS\/MS analysis of free biogenic monoamines and their metabolites in urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1099, 83\u201391. https:\/\/doi.org\/10.1016\/j.jchromb.2018.09.012","journal-title":"Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences"},{"key":"9978_CR39","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/toxsci\/kfx095","volume":"158","author":"DJ Conklin","year":"2017","unstructured":"Conklin, D. J., Malovichko, M. V., Zeller, I., Das, T. P., Krivokhizhina, T. V., Lynch, B. H., Lorkiewicz, P., Agarwal, A., Wickramasinghe, N., Haberzettl, P., et al. (2017). Biomarkers of chronic acrolein inhalation exposure in mice: implications for tobacco product-induced toxicity. Toxicological Sciences, 158, 263\u2013274. https:\/\/doi.org\/10.1093\/toxsci\/kfx095","journal-title":"Toxicological Sciences"},{"key":"9978_CR40","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3389\/fphys.2019.00277","volume":"10","author":"L Jin","year":"2019","unstructured":"Jin, L., Jagatheesan, G., Guo, L., Nystoriak, M., Malovichko, M., Lorkiewicz, P., Bhatnagar, A., Srivastava, S., & Conklin, D. J. (2019). Formaldehyde induces mesenteric artery relaxation via a sensitive transient receptor potential ankyrin-1 (TRPA1) and endothelium-dependent mechanism: Potential role in postprandial hyperemia. Frontiers in Physiology, 10, 277. https:\/\/doi.org\/10.3389\/fphys.2019.00277","journal-title":"Frontiers in Physiology"},{"key":"9978_CR41","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1159\/000490245","volume":"55","author":"L Jin","year":"2018","unstructured":"Jin, L., Lipinski, A., & Conklin, D. J. (2018). A simple method for normalization of aortic contractility. Journal of Vascular Research, 55, 177\u2013186. https:\/\/doi.org\/10.1159\/000490245","journal-title":"Journal of Vascular Research"},{"key":"9978_CR42","doi-asserted-by":"publisher","first-page":"e15120","DOI":"10.14814\/phy2.15120","volume":"9","author":"L Jin","year":"2021","unstructured":"Jin, L., & Conklin, D. J. (2021). A novel evaluation of endothelial dysfunction ex vivo: \u201cTeaching an Old Drug a New Trick.\u201d Physiological Reports, 9, e15120. https:\/\/doi.org\/10.14814\/phy2.15120","journal-title":"Physiological Reports"},{"key":"9978_CR43","doi-asserted-by":"publisher","DOI":"10.1113\/EP090341","author":"A Mills","year":"2022","unstructured":"Mills, A., Dakhlallah, D., Robinson, M., Kirk, A., Llavina, S., Boyd, J. W., Chantler, P. D., & Olfert, I. M. (2022). Short-term effects of electronic cigarettes on cerebrovascular function: A time course study. Experimental Physiology. https:\/\/doi.org\/10.1113\/EP090341","journal-title":"Experimental Physiology"},{"key":"9978_CR44","doi-asserted-by":"publisher","first-page":"6088","DOI":"10.1038\/s41467-022-33203-1","volume":"13","author":"AP Carll","year":"2022","unstructured":"Carll, A. P., Arab, C., Salatini, R., Miles, M. D., Nystoriak, M. A., Fulghum, K. L., Riggs, D. W., Shirk, G. A., Theis, W. S., Talebi, N., et al. (2022). E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice. Nature Communications, 13, 6088. https:\/\/doi.org\/10.1038\/s41467-022-33203-1","journal-title":"Nature Communications"},{"key":"9978_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1021\/acs.chemrestox.1c00328","volume":"35","author":"P Lorkiewicz","year":"2022","unstructured":"Lorkiewicz, P., Keith, R., Lynch, J., Jin, L., Theis, W., Krivokhizhina, T., Riggs, D., Bhatnagar, A., Srivastava, S., & Conklin, D. J. (2022). Electronic cigarette solvents, JUUL E-liquids, and biomarkers of exposure. in vivo evidence for acrolein and glycidol in E-Cig-derived aerosols. Chemical Research in Toxicology, 35, 283\u2013292. https:\/\/doi.org\/10.1021\/acs.chemrestox.1c00328","journal-title":"Chemical Research in Toxicology"},{"key":"9978_CR46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/s0034-5687(01)00234-1","volume":"127","author":"F Kratschmer","year":"2001","unstructured":"Kratschmer, F. (2001). On reflexes from the nasal mucous membrane on respiration and circulation. Respiration Physiology, 127, 93\u2013104. https:\/\/doi.org\/10.1016\/s0034-5687(01)00234-1","journal-title":"Respiration Physiology"},{"key":"9978_CR47","doi-asserted-by":"publisher","first-page":"115120","DOI":"10.1016\/j.taap.2020.115120","volume":"402","author":"J Lynch","year":"2020","unstructured":"Lynch, J., Jin, L., Richardson, A., Jagatheesan, G., Lorkiewicz, P., Xie, Z., Theis, W. S., Shirk, G., Malovichko, M. V., Bhatnagar, A., et al. (2020). Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1. Toxicology and Applied Pharmacology, 402, 115120. https:\/\/doi.org\/10.1016\/j.taap.2020.115120","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9978_CR48","doi-asserted-by":"publisher","first-page":"115012","DOI":"10.1016\/j.taap.2020.115012","volume":"398","author":"L Jin","year":"2020","unstructured":"Jin, L., Jagatheesan, G., Lynch, J., Guo, L., & Conklin, D. J. (2020). Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1). Toxicology and Applied Pharmacology, 398, 115012. https:\/\/doi.org\/10.1016\/j.taap.2020.115012","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9978_CR49","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1056\/NEJM199601183340303","volume":"334","author":"DS Celermajer","year":"1996","unstructured":"Celermajer, D. S., Adams, M. R., Clarkson, P., Robinson, J., McCredie, R., Donald, A., & Deanfield, J. E. (1996). Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. New England Journal of Medicine, 334, 150\u2013154.","journal-title":"New England Journal of Medicine"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-09978-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-025-09978-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-09978-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:30:27Z","timestamp":1741933827000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-025-09978-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["9978"],"URL":"https:\/\/doi.org\/10.1007\/s12012-025-09978-2","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,25]]},"assertion":[{"value":"1 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflicts of interest in this paper. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the Food and Drug Administration\/Center for Tobacco Products, Department of Defense, or the American Heart Association.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}