{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:40:18Z","timestamp":1784310018284,"version":"3.55.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82270494"],"award-info":[{"award-number":["82270494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82300492"],"award-info":[{"award-number":["82300492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170523"],"award-info":[{"award-number":["82170523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Basic Research Program of Science and Technology Department of Shanxi Province","award":["202103021223418"],"award-info":[{"award-number":["202103021223418"]}]},{"name":"Scientific Research Project of Health Commission in Shanxi Province","award":["2023XG009 and 2023RC008"],"award-info":[{"award-number":["2023XG009 and 2023RC008"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2023M732154"],"award-info":[{"award-number":["2023M732154"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-181"],"award-info":[{"award-number":["2023-181"]}]},{"name":"Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province","award":["20230054"],"award-info":[{"award-number":["20230054"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s12012-025-09982-6","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T07:56:57Z","timestamp":1741334217000},"page":"719-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Downregulation of HSPB1 and MGST1 Promotes Ferroptosis and Impacts Immune Infiltration in Diabetic Cardiomyopathy"],"prefix":"10.1007","volume":"25","author":[{"given":"Yaoli","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"issue":"1","key":"9982_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","volume":"61","author":"G Jia","year":"2018","unstructured":"Jia, G., Whaley-Connell, A., & Sowers, J. R. (2018). Diabetic cardiomyopathy: A hyperglycaemia- and insulin-resistance-induced heart disease. Diabetologia, 61(1), 21\u201328. https:\/\/doi.org\/10.1007\/s00125-017-4390-4","journal-title":"Diabetologia"},{"issue":"4","key":"9982_CR2","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/circresaha.117.311586","volume":"122","author":"G Jia","year":"2018","unstructured":"Jia, G., Hill, M. A., & Sowers, J. R. (2018). Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity. Circulation Research, 122(4), 624\u2013638. https:\/\/doi.org\/10.1161\/circresaha.117.311586","journal-title":"Circulation Research"},{"issue":"9","key":"9982_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41569-020-0339-2","volume":"17","author":"Y Tan","year":"2020","unstructured":"Tan, Y., Zhang, Z., Zheng, C., Wintergerst, K. A., Keller, B. B., & Cai, L. (2020). Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: Preclinical and clinical evidence. Nature Reviews Cardiology, 17(9), 585\u2013607. https:\/\/doi.org\/10.1038\/s41569-020-0339-2","journal-title":"Nature Reviews Cardiology"},{"issue":"6","key":"9982_CR4","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1161\/circresaha.115.306565","volume":"118","author":"JG Travers","year":"2016","unstructured":"Travers, J. G., Kamal, F. A., Robbins, J., Yutzey, K. E., & Blaxall, B. C. (2016). Cardiac fibrosis: The fibroblast awakens. Circulation research, 118(6), 1021\u20131040. https:\/\/doi.org\/10.1161\/circresaha.115.306565","journal-title":"Circulation research"},{"issue":"12","key":"9982_CR5","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1161\/circresaha.110.235531","volume":"108","author":"CL Smith","year":"2011","unstructured":"Smith, C. L., Baek, S. T., Sung, C. Y., & Tallquist, M. D. (2011). Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circulation Research, 108(12), e15-26. https:\/\/doi.org\/10.1161\/circresaha.110.235531","journal-title":"Circulation Research"},{"issue":"1","key":"9982_CR6","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3346\/jkms.2009.24.1.32","volume":"24","author":"SY Choi","year":"2009","unstructured":"Choi, S. Y., Chang, H. J., Choi, S. I., Kim, K. I., Cho, Y. S., Youn, T. J., Chung, W. Y., Chae, I. H., Choi, D. J., Kim, H. S., Kim, C. H., Oh, B. H., & Kim, M. H. (2009). Long-term exercise training attenuates age-related diastolic dysfunction: Association of myocardial collagen cross-linking. Journal of Korean Medical Science, 24(1), 32\u201339. https:\/\/doi.org\/10.3346\/jkms.2009.24.1.32","journal-title":"Journal of Korean Medical Science"},{"issue":"4","key":"9982_CR7","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","volume":"99","author":"DP Del Re","year":"2019","unstructured":"Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019). Fundamental mechanisms of regulated cell death and implications for heart disease. Physiological Reviews, 99(4), 1765\u20131817. https:\/\/doi.org\/10.1152\/physrev.00022.2018","journal-title":"Physiological Reviews"},{"issue":"5","key":"9982_CR8","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., Morrison, B., 3rd., & Stockwell, B. R. (2012). Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 149(5), 1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"issue":"Pt A","key":"9982_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2015.07.019","volume":"88","author":"V Berdoukas","year":"2015","unstructured":"Berdoukas, V., Coates, T. D., & Cabantchik, Z. I. (2015). Iron and oxidative stress in cardiomyopathy in thalassemia. Free Radical Biology & Medicine, 88(Pt A), 3\u20139. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.07.019","journal-title":"Free Radical Biology & Medicine"},{"issue":"7","key":"9982_CR10","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"X Fang","year":"2019","unstructured":"Fang, X., Wang, H., Han, D., Xie, E., Yang, X., Wei, J., Gu, S., Gao, F., Zhu, N., Yin, X., Cheng, Q., Zhang, P., Dai, W., Chen, J., Yang, F., Yang, H. T., Linkermann, A., Gu, W., Min, J., & Wang, F. (2019). Ferroptosis as a target for protection against cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America, 116(7), 2672\u20132680. https:\/\/doi.org\/10.1073\/pnas.1821022116","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"9982_CR11","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1161\/circresaha.114.300559","volume":"114","author":"YR Chen","year":"2014","unstructured":"Chen, Y. R., & Zweier, J. L. (2014). Cardiac mitochondria and reactive oxygen species generation. Circulation Research, 114(3), 524\u2013537. https:\/\/doi.org\/10.1161\/circresaha.114.300559","journal-title":"Circulation Research"},{"key":"9982_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5028181","author":"VP Bajic","year":"2019","unstructured":"Bajic, V. P., Van Neste, C., Obradovic, M., Zafirovic, S., Radak, D., Bajic, V. B., Essack, M., & Isenovic, E. R. (2019). Glutathione \u2018\u201credox homeostasis\u201d\u2019 and its relation to cardiovascular disease. Oxidative Medicine and Cellular Longevity. https:\/\/doi.org\/10.1155\/2019\/5028181","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"9982_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq537","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley, D., Donaldson, S. L., Comes, O., Zuberi, K., Badrawi, R., Chao, P., Franz, M., Grouios, C., Kazi, F., Lopes, C. T., Maitland, A., Mostafavi, S., Montojo, J., Shao, Q., Wright, G., Bader, G. D., & Morris, Q. (2010). The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Research. https:\/\/doi.org\/10.1093\/nar\/gkq537","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"9982_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman, A. M., Liu, C. L., Green, M. R., Gentles, A. J., Feng, W., Xu, Y., Hoang, C. D., Diehn, M., & Alizadeh, A. A. (2015). Robust enumeration of cell subsets from tissue expression profiles. Nature Methods, 12(5), 453\u2013457. https:\/\/doi.org\/10.1038\/nmeth.3337","journal-title":"Nature Methods"},{"issue":"15","key":"9982_CR15","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1161\/circulationaha.122.063073","volume":"147","author":"Z Meng","year":"2023","unstructured":"Meng, Z., Zhang, Z., Zhao, J., Liu, C., Yao, P., Zhang, L., Xie, D., Lau, W. B., Tsukuda, J., Christopher, T. A., Lopez, B., Zhu, D., Liu, D., Zhang, J. R., Gao, E., Ischiropoulos, H., Koch, W., Ma, X., & Wang, Y. (2023). Nitrative modification of caveolin-3: A novel mechanism of cardiac insulin resistance and a potential therapeutic target against ischemic heart failure in prediabetic animals. Circulation, 147(15), 1162\u20131179. https:\/\/doi.org\/10.1161\/circulationaha.122.063073","journal-title":"Circulation"},{"issue":"22","key":"9982_CR16","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1161\/circulationaha.117.029557","volume":"136","author":"W Yan","year":"2017","unstructured":"Yan, W., Guo, Y., Tao, L., Lau, W. B., Gan, L., Yan, Z., Guo, R., Gao, E., Wong, G. W., Koch, W. L., Wang, Y., & Ma, X. L. (2017). C1q\/tumor necrosis factor-related protein-9 regulates the fate of implanted mesenchymal stem cells and mobilizes their protective effects against ischemic heart injury via multiple novel signaling pathways. Circulation, 136(22), 2162\u20132177. https:\/\/doi.org\/10.1161\/circulationaha.117.029557","journal-title":"Circulation"},{"key":"9982_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.09.003","author":"J Mu","year":"2020","unstructured":"Mu, J., Zhang, D., Tian, Y., Xie, Z., & Zou, M. H. (2020). BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1\/Parkin-mediated mitophagy in vivo. Journal of Molecular and Cellular Cardiology. https:\/\/doi.org\/10.1016\/j.yjmcc.2020.09.003","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"6","key":"9982_CR18","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41419-021-03772-y","volume":"12","author":"J Gao","year":"2021","unstructured":"Gao, J., Fan, J., Meng, Z., Wang, R., Liu, C., Liu, J., Liang, B., Wang, J., Xie, Y., Zhao, J., Guo, R., Zhao, J., Ma, X., Jiao, X., Cao, J., & Wang, Y. (2021). Nicotine aggravates vascular adiponectin resistance via ubiquitin-mediated adiponectin receptor degradation in diabetic apolipoprotein E knockout mouse. Cell Death & Disease, 12(6), 508. https:\/\/doi.org\/10.1038\/s41419-021-03772-y","journal-title":"Cell Death & Disease"},{"issue":"8","key":"9982_CR19","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1111\/jcmm.17239","volume":"26","author":"X Wu","year":"2022","unstructured":"Wu, X., Qin, K., Iroegbu, C. D., Xiang, K., Peng, J., Guo, J., Yang, J., & Fan, C. (2022). Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from coronary artery disease. Journal of Cellular and Molecular Medicine, 26(8), 2177\u20132190. https:\/\/doi.org\/10.1111\/jcmm.17239","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"9982_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.904312","author":"H Ye","year":"2022","unstructured":"Ye, H., Wang, R., Wei, J., Wang, Y., Zhang, X., & Wang, L. (2022). Bioinformatics analysis identifies potential ferroptosis key gene in type 2 diabetic islet dysfunction. Frontiers in Endocrinology. https:\/\/doi.org\/10.3389\/fendo.2022.904312","journal-title":"Frontiers in Endocrinology"},{"issue":"1","key":"9982_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.apsb.2021.08.026","volume":"12","author":"J Wei","year":"2022","unstructured":"Wei, J., Zhao, Y., Liang, H., Du, W., & Wang, L. (2022). Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy. Acta Pharmaceutica Sinica. B, 12(1), 1\u201317. https:\/\/doi.org\/10.1016\/j.apsb.2021.08.026","journal-title":"Acta Pharmaceutica Sinica. B"},{"issue":"2","key":"9982_CR22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1089\/dna.2019.5097","volume":"39","author":"W Li","year":"2020","unstructured":"Li, W., Li, W., Leng, Y., Xiong, Y., & Xia, Z. (2020). Ferroptosis Is involved in diabetes myocardial ischemia\/reperfusion injury through endoplasmic reticulum stress. DNA and Cell Biology, 39(2), 210\u2013225. https:\/\/doi.org\/10.1089\/dna.2019.5097","journal-title":"DNA and Cell Biology"},{"issue":"1","key":"9982_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","volume":"20","author":"X Fang","year":"2023","unstructured":"Fang, X., Ardehali, H., Min, J., & Wang, F. (2023). The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nature Reviews Cardiology, 20(1), 7\u201323. https:\/\/doi.org\/10.1038\/s41569-022-00735-4","journal-title":"Nature Reviews Cardiology"},{"issue":"3","key":"9982_CR24","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.jacc.2017.11.019","volume":"71","author":"TH Marwick","year":"2018","unstructured":"Marwick, T. H., Ritchie, R., Shaw, J. E., & Kaye, D. (2018). Implications of underlying mechanisms for the recognition and management of diabetic cardiomyopathy. Journal of the American College of Cardiology, 71(3), 339\u2013351. https:\/\/doi.org\/10.1016\/j.jacc.2017.11.019","journal-title":"Journal of the American College of Cardiology"},{"issue":"11","key":"9982_CR25","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1161\/circresaha.116.306923","volume":"118","author":"MS Shah","year":"2016","unstructured":"Shah, M. S., & Brownlee, M. (2016). Molecular and cellular mechanisms of cardiovascular disorders in diabetes. Circulation Research, 118(11), 1808\u20131829. https:\/\/doi.org\/10.1161\/circresaha.116.306923","journal-title":"Circulation Research"},{"key":"9982_CR26","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9999612","author":"W Sha","year":"2021","unstructured":"Sha, W., Hu, F., Xi, Y., Chu, Y., & Bu, S. (2021). Mechanism of ferroptosis and its role in type 2 diabetes mellitus. Journal of Diabetes Research. https:\/\/doi.org\/10.1155\/2021\/9999612","journal-title":"Journal of Diabetes Research"},{"issue":"8","key":"9982_CR27","doi-asserted-by":"publisher","first-page":"e371","DOI":"10.1038\/oncsis.2017.65","volume":"6","author":"Z Fan","year":"2017","unstructured":"Fan, Z., Wirth, A. K., Chen, D., Wruck, C. J., Rauh, M., Buchfelder, M., & Savaskan, N. (2017). Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis. Oncogenesis, 6(8), e371. https:\/\/doi.org\/10.1038\/oncsis.2017.65","journal-title":"Oncogenesis"},{"key":"9982_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00466","author":"M Abdalkader","year":"2018","unstructured":"Abdalkader, M., Lampinen, R., Kanninen, K. M., Malm, T. M., & Liddell, J. R. (2018). Targeting Nrf2 to suppress ferroptosis and mitochondrial dysfunction in neurodegeneration. Frontiers in Neuroscience. https:\/\/doi.org\/10.3389\/fnins.2018.00466","journal-title":"Frontiers in Neuroscience"},{"key":"9982_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109633","author":"Y Shang","year":"2020","unstructured":"Shang, Y., Luo, M., Yao, F., Wang, S., Yuan, Z., & Yang, Y. (2020). Ceruloplasmin suppresses ferroptosis by regulating iron homeostasis in hepatocellular carcinoma cells. Cellular Signalling. https:\/\/doi.org\/10.1016\/j.cellsig.2020.109633","journal-title":"Cellular Signalling"},{"key":"9982_CR30","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s407588","author":"H Lu","year":"2023","unstructured":"Lu, H., Xie, Y., Zhou, Z., Hong, P., & Chen, J. (2023). Identification of novel targets for treatment of dilated cardiomyopathy based on the ferroptosis and immune heterogeneity. Journal of Inflammation Research. https:\/\/doi.org\/10.2147\/jir.s407588","journal-title":"Journal of Inflammation Research"},{"issue":"21","key":"9982_CR31","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1161\/circulationaha.119.043053","volume":"141","author":"Z Ren","year":"2020","unstructured":"Ren, Z., Yu, P., Li, D., Li, Z., Liao, Y., Wang, Y., Zhou, B., & Wang, L. (2020). Single-cell reconstruction of progression trajectory reveals intervention principles in pathological cardiac hypertrophy. Circulation, 141(21), 1704\u20131719. https:\/\/doi.org\/10.1161\/circulationaha.119.043053","journal-title":"Circulation"},{"issue":"1","key":"9982_CR32","doi-asserted-by":"publisher","first-page":"H124","DOI":"10.1152\/ajpheart.00028.2019","volume":"317","author":"RM Blanton","year":"2019","unstructured":"Blanton, R. M., Carrillo-Salinas, F. J., & Alcaide, P. (2019). T-cell recruitment to the heart: friendly guests or unwelcome visitors? american journal of physiology. Heart and Circulatory Physiology, 317(1), H124-h140. https:\/\/doi.org\/10.1152\/ajpheart.00028.2019","journal-title":"Heart and Circulatory Physiology"},{"issue":"1","key":"9982_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","volume":"20","author":"SA Dick","year":"2019","unstructured":"Dick, S. A., Macklin, J. A., Nejat, S., Momen, A., Clemente-Casares, X., Althagafi, M. G., Chen, J., Kantores, C., Hosseinzadeh, S., Aronoff, L., Wong, A., Zaman, R., Barbu, I., Besla, R., Lavine, K. J., Razani, B., Ginhoux, F., Husain, M., Cybulsky, M. I., \u2026 Epelman, S. (2019). Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction. Nature Immunology, 20(1), 29\u201339. https:\/\/doi.org\/10.1038\/s41590-018-0272-2","journal-title":"Nature Immunology"},{"issue":"6","key":"9982_CR34","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41569-022-00701-0","volume":"19","author":"A Wong","year":"2022","unstructured":"Wong, A., Hamidzada, H., & Epelman, S. (2022). A cardioimmunologist\u2019s toolkit: Genetic tools to dissect immune cells in cardiac disease. Nature Reviews Cardiology, 19(6), 395\u2013413. https:\/\/doi.org\/10.1038\/s41569-022-00701-0","journal-title":"Nature Reviews Cardiology"},{"issue":"2","key":"9982_CR35","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gasc\u00f3n, S., Hatzios, S. K., Kagan, V. E., Noel, K., Jiang, X., Linkermann, A., Murphy, M. E., Overholtzer, M., Oyagi, A., Pagnussat, G. C., Park, J., Ran, Q., \u2026 Zhang, D. D. (2017). Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell, 171(2), 273\u2013285. https:\/\/doi.org\/10.1016\/j.cell.2017.09.021","journal-title":"Cell"},{"issue":"8","key":"9982_CR36","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula, P., Zhuang, L., & Gan, B. (2021). Cystine transporter SLC7A11\/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy. Protein & cell, 12(8), 599\u2013620. https:\/\/doi.org\/10.1007\/s13238-020-00789-5","journal-title":"Protein & cell"},{"key":"9982_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2020.110222","author":"A Konstorum","year":"2020","unstructured":"Konstorum, A., Tesfay, L., Paul, B. T., Torti, F. M., Laubenbacher, R. C., & Torti, S. V. (2020). Systems biology of ferroptosis: A modeling approach. Journal of theoretical biology. https:\/\/doi.org\/10.1016\/j.jtbi.2020.110222","journal-title":"Journal of theoretical biology"},{"key":"9982_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.08.028","author":"D Traxler","year":"2017","unstructured":"Traxler, D., Lainscak, M., Simader, E., Ankersmit, H. J., & Jug, B. (2017). Heat shock protein 27 acts as a predictor of prognosis in chronic heart failure patients. Clinica Chimica Acta. https:\/\/doi.org\/10.1016\/j.cca.2017.08.028","journal-title":"Clinica Chimica Acta"},{"key":"9982_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117251","author":"S Li","year":"2020","unstructured":"Li, S., Liang, M., Pan, Y., Wang, M., Gao, D., Shang, H., Su, Q., & Laher, I. (2020). Exercise modulates heat shock protein 27 activity in diabetic cardiomyopathy. Life Sciences. https:\/\/doi.org\/10.1016\/j.lfs.2019.117251","journal-title":"Life Sciences"},{"issue":"3","key":"9982_CR40","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.2337\/dc13-1780","volume":"37","author":"K Pourhamidi","year":"2014","unstructured":"Pourhamidi, K., Sk\u00e4rstrand, H., Dahlin, L. B., & Rolandsson, O. (2014). HSP27 concentrations are lower in patients with type 1 diabetes and correlate with large nerve fiber dysfunction. Diabetes Care, 37(3), e49-50. https:\/\/doi.org\/10.2337\/dc13-1780","journal-title":"Diabetes Care"},{"issue":"1","key":"9982_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.brainres.2005.11.008","volume":"1068","author":"ME Dodge","year":"2006","unstructured":"Dodge, M. E., Wang, J., Guy, C., Rankin, S., Rahimtula, M., & Mearow, K. M. (2006). Stress-induced heat shock protein 27 expression and its role in dorsal root ganglion neuronal survival. Brain Research, 1068(1), 34\u201348. https:\/\/doi.org\/10.1016\/j.brainres.2005.11.008","journal-title":"Brain Research"},{"issue":"1","key":"9982_CR42","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/cvr\/cvy163","volume":"115","author":"Y Wang","year":"2019","unstructured":"Wang, Y., Liu, J., Kong, Q., Cheng, H., Tu, F., Yu, P., Liu, Y., Zhang, X., Li, C., Li, Y., Min, X., Du, S., Ding, Z., & Liu, L. (2019). Cardiomyocyte-specific deficiency of HSPB1 worsens cardiac dysfunction by activating NF\u03baB-mediated leucocyte recruitment after myocardial infarction. Cardiovascular Research, 115(1), 154\u2013167. https:\/\/doi.org\/10.1093\/cvr\/cvy163","journal-title":"Cardiovascular Research"},{"issue":"2","key":"9982_CR43","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3109\/03602532.2011.558511","volume":"43","author":"R Morgenstern","year":"2011","unstructured":"Morgenstern, R., Zhang, J., & Johansson, K. (2011). Microsomal glutathione transferase 1 mechanism and functional roles. Drug Metabolism Reviews, 43(2), 300\u2013306. https:\/\/doi.org\/10.3109\/03602532.2011.558511","journal-title":"Drug Metabolism Reviews"},{"key":"9982_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109562","author":"B Zeng","year":"2020","unstructured":"Zeng, B., Ge, C., Li, R., Zhang, Z., Fu, Q., Li, Z., Lin, Z., Liu, L., Xue, Y., Xu, Y., He, J., Guo, H., Li, C., Huang, W., Song, X., & Huang, Y. (2020). Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis. Biomedicine & Pharmacotherapy. https:\/\/doi.org\/10.1016\/j.biopha.2019.109562","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"9982_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.04.013","author":"L Br\u00e4utigam","year":"2018","unstructured":"Br\u00e4utigam, L., Zhang, J., Dreij, K., Spahiu, L., Holmgren, A., Abe, H., Tew, K. D., Townsend, D. M., Kelner, M. J., Morgenstern, R., & Johansson, K. (2018). MGST1, a GSH transferase\/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biology. https:\/\/doi.org\/10.1016\/j.redox.2018.04.013","journal-title":"Redox Biology"},{"issue":"6","key":"9982_CR46","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.chembiol.2021.01.006","volume":"28","author":"F Kuang","year":"2021","unstructured":"Kuang, F., Liu, J., Xie, Y., Tang, D., & Kang, R. (2021). MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells. Cell Chemical Biology, 28(6), 765\u2013775. https:\/\/doi.org\/10.1016\/j.chembiol.2021.01.006","journal-title":"Cell Chemical Biology"},{"issue":"4","key":"9982_CR47","doi-asserted-by":"publisher","first-page":"e24317","DOI":"10.1002\/jcla.24317","volume":"36","author":"J Yan","year":"2022","unstructured":"Yan, J., Ye, G., & Shao, Y. (2022). High expression of the ferroptosis-associated MGST1 gene in relation to poor outcome and maladjusted immune cell infiltration in uterine corpus endometrial carcinoma. Journal of Clinical Laboratory Analysis, 36(4), e24317. https:\/\/doi.org\/10.1002\/jcla.24317","journal-title":"Journal of Clinical Laboratory Analysis"},{"issue":"26","key":"9982_CR48","doi-asserted-by":"publisher","first-page":"23683","DOI":"10.1021\/acsomega.3c01782","volume":"8","author":"Y Li","year":"2023","unstructured":"Li, Y., Xu, X., Wang, X., Zhang, C., Hu, A., & Li, Y. (2023). MGST1 expression is associated with poor prognosis, enhancing the Wnt\/\u03b2-catenin pathway via regulating AKT and inhibiting ferroptosis in gastric cancer. ACS Omega, 8(26), 23683\u201323694. https:\/\/doi.org\/10.1021\/acsomega.3c01782","journal-title":"ACS Omega"},{"issue":"4","key":"9982_CR49","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1152\/physrev.00008.2013","volume":"93","author":"T Ganz","year":"2013","unstructured":"Ganz, T. (2013). Systemic iron homeostasis. Physiological Reviews, 93(4), 1721\u20131741. https:\/\/doi.org\/10.1152\/physrev.00008.2013","journal-title":"Physiological Reviews"},{"issue":"10","key":"9982_CR50","doi-asserted-by":"publisher","first-page":"3164","DOI":"10.1073\/pnas.1422373112","volume":"112","author":"S Lakhal-Littleton","year":"2015","unstructured":"Lakhal-Littleton, S., Wolna, M., Carr, C. A., Miller, J. J., Christian, H. C., Ball, V., Santos, A., Diaz, R., Biggs, D., Stillion, R., Holdship, P., Larner, F., Tyler, D. J., Clarke, K., Davies, B., & Robbins, P. A. (2015). Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function. Proceedings of the National Academy of Sciences of the United States of America, 112(10), 3164\u20133169. https:\/\/doi.org\/10.1073\/pnas.1422373112","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"9982_CR51","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/circresaha.120.316509","volume":"127","author":"X Fang","year":"2020","unstructured":"Fang, X., Cai, Z., Wang, H., Han, D., Cheng, Q., Zhang, P., Gao, F., Yu, Y., Song, Z., Wu, Q., An, P., Huang, S., Pan, J., Chen, H. Z., Chen, J., Linkermann, A., Min, J., & Wang, F. (2020). Loss of cardiac ferritin h facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circulation Research, 127(4), 486\u2013501. https:\/\/doi.org\/10.1161\/circresaha.120.316509","journal-title":"Circulation Research"},{"issue":"6","key":"9982_CR52","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.2019002907","volume":"136","author":"Y Yu","year":"2020","unstructured":"Yu, Y., Jiang, L., Wang, H., Shen, Z., Cheng, Q., Zhang, P., Wang, J., Wu, Q., Fang, X., Duan, L., Wang, S., Wang, K., An, P., Shao, T., Chung, R. T., Zheng, S., Min, J., & Wang, F. (2020). Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood, 136(6), 726\u2013739. https:\/\/doi.org\/10.1182\/blood.2019002907","journal-title":"Blood"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-09982-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-025-09982-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-09982-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T02:15:42Z","timestamp":1745374542000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-025-09982-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["9982"],"URL":"https:\/\/doi.org\/10.1007\/s12012-025-09982-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5153598\/v1","asserted-by":"object"}]},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"25 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal use protocol was approved by the Ethics Committee of Shanxi Provincial People Hospital (Approval No. 482). The study was conducted in accordance with local legislation and institutional requirements.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}