{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:54:15Z","timestamp":1789754055359,"version":"4.0.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100739"],"award-info":[{"award-number":["32100739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12012-025-10077-5","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:04:57Z","timestamp":1769522697000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Large-Scale Disease-Wide Association Study Identified Predisposition Links Between Influenza and Cardiovascular Diseases"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-7701","authenticated-orcid":false,"given":"Ming","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"10077_CR1","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1038\/nm1141","volume":"10","author":"P Palese","year":"2004","unstructured":"Palese, P. (2004). Influenza: Old and new threats. Nature Medicine, 10, S82-87.","journal-title":"Nature Medicine"},{"key":"10077_CR2","unstructured":"WHO. (2011). Pandemic influenza preparedness framework for the sharing of influenza viruses and access to vaccines and other benefits. https:\/\/www.who.int\/europe\/groups\/pandemic-influenza-preparedness-(pip)-framework"},{"key":"10077_CR3","unstructured":"WHO. (2024). Pandemic influenza preparedness framework: partnership contribution high-level implementation plan III 2024\u20132030. https:\/\/www.who.int\/publications\/i\/item\/9789240070141"},{"key":"10077_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0140-6736(24)01136-X","volume":"404","author":"T Greenhalgh","year":"2024","unstructured":"Greenhalgh, T., Sivan, M., Perlowski, A., & Nikolich, J. Z. (2024). Long COVID: A clinical update. Lancet, 404, 707\u2013724.","journal-title":"Lancet"},{"key":"10077_CR5","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1038\/s41591-024-02987-8","volume":"30","author":"M Cai","year":"2024","unstructured":"Cai, M., Xie, Y., Topol, E. J., & Al-Aly, Z. (2024). Three-year outcomes of post-acute sequelae of COVID-19. Nature Medicine, 30, 1564\u20131573.","journal-title":"Nature Medicine"},{"key":"10077_CR6","volume":"371","author":"Y Xie","year":"2020","unstructured":"Xie, Y., Bowe, B., Maddukuri, G., & Al-Aly, Z. (2020). Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: Cohort study. BMJ (Clinical Research Edition), 371, Article m4677.","journal-title":"BMJ (Clinical Research Edition)"},{"key":"10077_CR7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S1473-3099(23)00684-9","volume":"24","author":"Y Xie","year":"2024","unstructured":"Xie, Y., Choi, T., & Al-Aly, Z. (2024). Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: A cohort study. Lancet Infectious Diseases, 24, 239\u2013255.","journal-title":"Lancet Infectious Diseases"},{"key":"10077_CR8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1001\/archinte.1919.00090250027002","volume":"24","author":"B Lucke","year":"1919","unstructured":"Lucke, B., Wight, T., & Kime, E. (1919). Pathologic anatomy and bacteriology of influenza: Epidemic of autumn, 1918. Archives of Internal Medicine, 24, 154\u2013237.","journal-title":"Archives of Internal Medicine"},{"key":"10077_CR9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1056\/NEJM195903122601101","volume":"260","author":"R Oseasohn","year":"1959","unstructured":"Oseasohn, R., Adelson, L., & Kaji, M. (1959). Clinicopathologic study of thirty-three fatal cases of Asian Influenza. New England Journal of Medicine, 260, 509\u2013518.","journal-title":"New England Journal of Medicine"},{"key":"10077_CR10","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/infdis\/jir861","volume":"205","author":"CD Paddock","year":"2012","unstructured":"Paddock, C. D., Liu, L., Denison, A. M., Bartlett, J. H., Holman, R. C., Deleon-Carnes, M., Emery, S. L., Drew, C. P., Shieh, W. J., Uyeki, T. M., & Zaki, S. R. (2012). Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection. Journal of Infectious Diseases, 205, 895\u2013905.","journal-title":"Journal of Infectious Diseases"},{"key":"10077_CR11","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1001\/jama.2013.279206","volume":"310","author":"JA Udell","year":"2013","unstructured":"Udell, J. A., Zawi, R., Bhatt, D. L., Keshtkar-Jahromi, M., Gaughran, F., Phrommintikul, A., Ciszewski, A., Vakili, H., Hoffman, E. B., Farkouh, M. E., & Cannon, C. P. (2013). Association between influenza vaccination and cardiovascular outcomes in high-risk patients: A meta-analysis. JAMA, 310, 1711\u20131720.","journal-title":"JAMA"},{"key":"10077_CR12","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1253\/circj.CJ-10-0833","volume":"74","author":"M Kodama","year":"2010","unstructured":"Kodama, M. (2010). Influenza myocarditis. Circulation Journal, 74, 2060\u20132061.","journal-title":"Circulation Journal"},{"key":"10077_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101740","volume":"55","author":"SS Chaves","year":"2023","unstructured":"Chaves, S. S., Nealon, J., Burkart, K. G., Modin, D., Biering-Sorensen, T., Ortiz, J. R., Vilchis-Tella, V. M., Wallace, L. E., Roth, G., Mahe, C., & Brauer, M. (2023). Global, regional and national estimates of influenza-attributable ischemic heart disease mortality. EClinicalMedicine, 55, Article 101740.","journal-title":"EClinicalMedicine"},{"key":"10077_CR14","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/acn3.545","volume":"5","author":"AK Boehme","year":"2018","unstructured":"Boehme, A. K., Luna, J., Kulick, E. R., Kamel, H., & Elkind, M. S. V. (2018). Influenza-like illness as a trigger for ischemic stroke. Annals of Clinical and Translational Neurology, 5, 456\u2013463.","journal-title":"Annals of Clinical and Translational Neurology"},{"key":"10077_CR15","doi-asserted-by":"publisher","first-page":"A5","DOI":"10.1093\/eurheartjsupp\/suac117","volume":"25","author":"KG Skaarup","year":"2023","unstructured":"Skaarup, K. G., Modin, D., Nielsen, L., Jensen, J. U. S., & Biering-Sorensen, T. (2023). Influenza and cardiovascular disease pathophysiology: Strings attached. European Heart Journal. Supplements, 25, A5\u2013A11.","journal-title":"European Heart Journal. Supplements"},{"key":"10077_CR16","doi-asserted-by":"publisher","first-page":"605","DOI":"10.7326\/M20-1509","volume":"173","author":"EJ Chow","year":"2020","unstructured":"Chow, E. J., Rolfes, M. A., O\u2019Halloran, A., Anderson, E. J., Bennett, N. M., Billing, L., Chai, S., Dufort, E., Herlihy, R., Kim, S., Lynfield, R., McMullen, C., Monroe, M. L., Schaffner, W., Spencer, M., Talbot, H. K., Thomas, A., Yousey-Hindes, K., Reed, C., & Garg, S. (2020). Acute Cardiovascular events associated with influenza in hospitalized adults\u202f: A cross-sectional study. Annals of Internal Medicine, 173, 605\u2013613.","journal-title":"Annals of Internal Medicine"},{"key":"10077_CR17","volume":"42","author":"A Bolton","year":"2022","unstructured":"Bolton, A., Thyagaturu, H., Ashraf, M., Carnahan, R., & Hodgson-Zingman, D. (2022). Effects of atrial fibrillation on outcomes of influenza hospitalization. International Journal of Cardiology, Heart and Vascular, 42, Article 101106.","journal-title":"International Journal of Cardiology, Heart and Vascular"},{"key":"10077_CR18","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/eurheartj\/ehm516","volume":"29","author":"TC Clayton","year":"2008","unstructured":"Clayton, T. C., Thompson, M., & Meade, T. W. (2008). Recent respiratory infection and risk of cardiovascular disease: Case-control study through a general practice database. European Heart Journal, 29, 96\u2013103.","journal-title":"European Heart Journal"},{"key":"10077_CR19","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S1473-3099(09)70233-6","volume":"9","author":"C Warren-Gash","year":"2009","unstructured":"Warren-Gash, C., Smeeth, L., & Hayward, A. C. (2009). Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: A systematic review. The Lancet Infectious Diseases, 9, 601\u2013610.","journal-title":"The Lancet Infectious Diseases"},{"key":"10077_CR20","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1007\/s00011-012-0449-3","volume":"61","author":"X Guan","year":"2012","unstructured":"Guan, X., Yang, W., Sun, X., Wang, L., Ma, B., Li, H., & Zhou, J. (2012). Association of influenza virus infection and inflammatory cytokines with acute myocardial infarction. Inflammation Research, 61, 591\u2013598.","journal-title":"Inflammation Research"},{"key":"10077_CR21","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1056\/NEJMoa1702090","volume":"378","author":"JC Kwong","year":"2018","unstructured":"Kwong, J. C., Schwartz, K. L., Campitelli, M. A., Chung, H., Crowcroft, N. S., Karnauchow, T., Katz, K., Ko, D. T., McGeer, A. J., McNally, D., Richardson, D. C., Rosella, L. C., Simor, A., Smieja, M., Zahariadis, G., & Gubbay, J. B. (2018). Acute myocardial infarction after laboratory-confirmed influenza infection. The New England Journal of Medicine, 378, 345\u2013353.","journal-title":"The New England Journal of Medicine"},{"key":"10077_CR22","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2300361","volume":"3","author":"AR de Boer","year":"2024","unstructured":"de Boer, A. R., Riezebos-Brilman, A., van Hout, D., van Mourik, M. S. M., Rumke, L. W., de Hoog, M. L. A., Vaartjes, I., & Bruijning-Verhagen, P. (2024). Influenza infection and acute myocardial infarction. NEJM Evidence, 3, Article EVIDoa2300361.","journal-title":"NEJM Evidence"},{"key":"10077_CR23","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm5371","volume":"8","author":"AD Kenney","year":"2022","unstructured":"Kenney, A. D., Aron, S. L., Gilbert, C., Kumar, N., Chen, P., Eddy, A., Zhang, L., Zani, A., Vargas-Maldonado, N., Speaks, S., Kawahara, J., Denz, P. J., Dorn, L., Accornero, F., Ma, J., Zhu, H., Rajaram, M. V. S., Cai, C., Langlois, R. A., & Yount, J. S. (2022). Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis. Science Advances, 8, Article eabm5371.","journal-title":"Science Advances"},{"key":"10077_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.pcad.2024.09.005","volume":"86","author":"M Zheng","year":"2024","unstructured":"Zheng, M., & Lavie, C. J. (2024). Landscape of stroke comorbidities: A disease-wide association study. Progress in Cardiovascular Diseases, 86, 96\u201399.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10077_CR25","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.euroneuro.2024.12.009","volume":"92","author":"M Zheng","year":"2025","unstructured":"Zheng, M. (2025). Disease-wide association study uncovers disease continuum network of unipolar depression. European Neuropsychopharmacology, 92, 74\u201376.","journal-title":"European Neuropsychopharmacology"},{"key":"10077_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.euroneuro.2025.01.002","volume":"93","author":"M Zheng","year":"2025","unstructured":"Zheng, M. (2025). Disease continuum centered on Parkinson\u2019s disease. European Neuropsychopharmacology, 93, 19\u201321.","journal-title":"European Neuropsychopharmacology"},{"key":"10077_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2025.111316","volume":"138","author":"M Zheng","year":"2025","unstructured":"Zheng, M. (2025). Snapshot of disease continuum centered on Alzheimer\u2019s disease: Exploring modifiable risk factors. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 138, Article 111316.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"10077_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2025.104540","volume":"109","author":"M Zheng","year":"2025","unstructured":"Zheng, M. (2025). Thinking bipolar disorder as a symptom rather than a disease. Asian Journal of Psychiatry, 109, Article 104540.","journal-title":"Asian Journal of Psychiatry"},{"key":"10077_CR29","unstructured":"Kurki, M. I., Karjalainen, J., Palta, P., Sipil\u00e4, T. P., Kristiansson, K., Donner, K., Reeve, M. P., Laivuori, H., Aavikko, M., & Kaunisto, M. A. (2022). FinnGen: Unique genetic insights from combining isolated population and national health register data. medRxiv."},{"key":"10077_CR30","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1001\/jamapsychiatry.2018.3658","volume":"76","author":"O Plana-Ripoll","year":"2019","unstructured":"Plana-Ripoll, O., Pedersen, C. B., Holtz, Y., Benros, M. E., Dalsgaard, S., de Jonge, P., Fan, C. C., Degenhardt, L., Ganna, A., Greve, A. N., Gunn, J., Iburg, K. M., Kessing, L. V., Lee, B. K., Lim, C. C. W., Mors, O., Nordentoft, M., Prior, A., Roest, A. M., \u2026 McGrath, J. J. (2019). Exploring comorbidity within mental disorders among a Danish National Population. JAMA Psychiatry, 76, 259\u2013270.","journal-title":"JAMA Psychiatry"},{"key":"10077_CR31","doi-asserted-by":"crossref","unstructured":"Frobert, O., Pedersen, I.B., Hjelholt, A.J., Erikstrup, C. and Cajander, S. (2025). The flu shot and cardiovascular Protection: Rethinking inflammation in ischemic heart disease. Atherosclerosis: 120405.","DOI":"10.1016\/j.atherosclerosis.2025.120405"},{"key":"10077_CR32","doi-asserted-by":"publisher","first-page":"4988","DOI":"10.1016\/j.vaccine.2015.07.006","volume":"33","author":"CA DiazGranados","year":"2015","unstructured":"DiazGranados, C. A., Robertson, C. A., Talbot, H. K., Landolfi, V., Dunning, A. J., & Greenberg, D. P. (2015). Prevention of serious events in adults 65 years of age or older: A comparison between high-dose and standard-dose inactivated influenza vaccines. Vaccine, 33, 4988\u20134993.","journal-title":"Vaccine"},{"key":"10077_CR33","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1080\/14760584.2018.1471989","volume":"17","author":"JKH Lee","year":"2018","unstructured":"Lee, J. K. H., Lam, G. K. L., Shin, T., Kim, J., Krishnan, A., Greenberg, D. P., & Chit, A. (2018). Efficacy and effectiveness of high-dose versus standard-dose influenza vaccination for older adults: A systematic review and meta-analysis. Expert Review of Vaccines, 17, 435\u2013443.","journal-title":"Expert Review of Vaccines"},{"key":"10077_CR34","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ahj.2017.04.003","volume":"189","author":"O Frobert","year":"2017","unstructured":"Frobert, O., Gotberg, M., Angeras, O., Jonasson, L., Erlinge, D., Engstrom, T., Persson, J., Jensen, S. E., Omerovic, E., James, S. K., Lagerqvist, B., Nilsson, J., Karegren, A., Moer, R., Yang, C., Agus, D. B., Erglis, A., Jensen, L. O., Jakobsen, L., \u2026 Pernow, J. (2017). Design and rationale for the Influenza vaccination After Myocardial Infarction (IAMI) trial. A registry-based randomized clinical trial. American Heart Journal, 189, 94\u2013102.","journal-title":"American Heart Journal"},{"key":"10077_CR35","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ahj.2019.02.009","volume":"212","author":"M Loeb","year":"2019","unstructured":"Loeb, M., Dokainish, H., Dans, A., Palileo-Villanueva, L. M., Roy, A., Karaye, K., Zhu, J., Liang, Y., Goma, F., Damasceno, A., AlHabib, K. F., Yonga, G., Mondo, C., Almahmeed, W., Al Mulla, A., & Yusuf, S. (2019). Randomized controlled trial of influenza vaccine in patients with heart failure to reduce adverse vascular events (IVVE): Rationale and design. American Heart Journal, 212, 36\u201344.","journal-title":"American Heart Journal"},{"key":"10077_CR36","doi-asserted-by":"publisher","first-page":"e1835","DOI":"10.1016\/S2214-109X(22)00432-6","volume":"10","author":"M Loeb","year":"2022","unstructured":"Loeb, M., Roy, A., Dokainish, H., Dans, A., Palileo-Villanueva, L. M., Karaye, K., Zhu, J., Liang, Y., Goma, F., Damasceno, A., Alhabib, K. F., Yonga, G., Mondo, C., Almahmeed, W., Al Mulla, A., Thanabalan, V., Rao-Melacini, P., Grinvalds, A., McCready, T., \u2026 Yusuf, S. (2022). Influenza vaccine to reduce adverse vascular events in patients with heart failure: a multinational randomised, double-blind, placebo-controlled trial. Lancet Global Health, 10, e1835\u2013e1844.","journal-title":"Lancet Global Health"},{"key":"10077_CR37","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/ehaa946.1133","author":"K Gonuguntla","year":"2020","unstructured":"Gonuguntla, K., Patil, S. P., & Rojulpote, C. (2020). Impact of influenza and pneumococcal vaccines upon in-hospital mortality in patients with heart failure: A retrospective cohort study in the United States. European Heart Journal. https:\/\/doi.org\/10.1093\/ehjci\/ehaa946.1133","journal-title":"European Heart Journal"},{"key":"10077_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126682","volume":"46","author":"A Dermenchyan","year":"2025","unstructured":"Dermenchyan, A., Choi, K. R., Bokhoor, P. R., Cho, D. J., Delavin, N. L. A., Chima-Melton, C., Han, M. A., & Fonarow, G. C. (2025). Receipt of respiratory vaccines among patients with heart failure in a multicenter health system registry. Vaccine, 46, Article 126682.","journal-title":"Vaccine"},{"key":"10077_CR39","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/S1473-3099(16)00129-8","volume":"16","author":"EA Belongia","year":"2016","unstructured":"Belongia, E. A., Simpson, M. D., King, J. P., Sundaram, M. E., Kelley, N. S., Osterholm, M. T., & McLean, H. Q. (2016). Variable influenza vaccine effectiveness by subtype: A systematic review and meta-analysis of test-negative design studies. The Lancet Infectious Diseases, 16, 942\u2013951.","journal-title":"The Lancet Infectious Diseases"},{"key":"10077_CR40","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/S1473-3099(24)00176-2","volume":"24","author":"GBD 2021 Lower Respiratory Infections and Antimicrobial Resistance Collaborators","year":"2024","unstructured":"GBD 2021 Lower Respiratory Infections and Antimicrobial Resistance Collaborators. (2024). Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: A systematic analysis from the Global Burden of Disease Study 2021. The Lancet Infectious Diseases, 24, 974\u20131002.","journal-title":"The Lancet Infectious Diseases"},{"key":"10077_CR41","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/j.jacc.2023.04.021","volume":"81","author":"LC Godoy","year":"2023","unstructured":"Godoy, L. C., Farkouh, M. E., Austin, P. C., Shah, B. R., Qiu, F., Jackevicius, C. A., Wijeysundera, H. C., Krumholz, H. M., & Ko, D. T. (2023). Association of beta-blocker therapy with cardiovascular outcomes in patients with stable ischemic heart disease. Journal of the American College of Cardiology, 81, 2299\u20132311.","journal-title":"Journal of the American College of Cardiology"},{"key":"10077_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113287","volume":"153","author":"D Felkle","year":"2022","unstructured":"Felkle, D., Jarczynski, M., Kaleta, K., Zieba, K., & Nazimek, K. (2022). The immunomodulatory effects of antihypertensive therapy: A review. Biomedicine & Pharmacotherapy, 153, Article 113287.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10077_CR43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.pcad.2024.09.002","volume":"86","author":"M Zheng","year":"2024","unstructured":"Zheng, M., & Lavie, C. J. (2024). COVID-19 susceptibility causally related to stroke risk: Using SARS-CoV-2 infection as a natural test of disease predisposition? Progress in Cardiovascular Diseases, 86, 89\u201392.","journal-title":"Progress in Cardiovascular Diseases"},{"key":"10077_CR44","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s12012-025-09996-0","volume":"25","author":"M Zheng","year":"2025","unstructured":"Zheng, M. (2025). COVID-19 predisposition inherently increases cardiovascular risk before SARS-CoV-2 infection. Cardiovascular Toxicology, 25, 821\u2013829.","journal-title":"Cardiovascular Toxicology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-10077-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-025-10077-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-10077-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:05:39Z","timestamp":1771949139000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-025-10077-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10077"],"URL":"https:\/\/doi.org\/10.1007\/s12012-025-10077-5","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"14 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No human subjects were directly involved in this study. All data used in this research were obtained from de-identified medical records, as part of the FinnGen project. The FinnGen study received ethical approval from the Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa (HUS), under approval number HUS\/990\/2017. The use of these data for secondary analysis was conducted in accordance with ethical standards. Given that the study relied on pre-existing, anonymized data, patient consent was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to participate"}}],"article-number":"20"}}