{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:14:38Z","timestamp":1779898478075,"version":"3.53.1"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s12012-025-10082-8","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:28:50Z","timestamp":1766575730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post-pubertal Susceptibility to Cadmium-Induced Cardiac Injury: Role of Metallothionein, Antioxidant Defense, and Endocrine Modulation"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8199-2352","authenticated-orcid":false,"given":"Raktim","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0587-4466","authenticated-orcid":false,"given":"Megha","family":"Dave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-1423","authenticated-orcid":false,"given":"Selvaraj","family":"Jayaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Guerriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2326-0994","authenticated-orcid":false,"given":"A. V.","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"issue":"1","key":"10082_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-015-1579-5","volume":"90","author":"M Valko","year":"2016","unstructured":"Valko, M., Jomova, K., Rhodes, C. J., Ku\u010da, K., & Mus\u00edlek, K. (2016). Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Archives of Toxicology, 90(1), 1\u201337. https:\/\/doi.org\/10.1007\/s00204-015-1579-5","journal-title":"Archives of Toxicology"},{"key":"10082_CR2","doi-asserted-by":"publisher","unstructured":"Bimonte, V. M., Catanzaro, G., Po, A., Trocchianesi, S., Besharat, Z. M., Spinello, Z., \u2026 & Migliaccio, S. (2023). The endocrine disruptor cadmium modulates the androgen\u2013estrogen receptors ratio and induces inflammatory cytokines in luminal (A) cell models of breast cancer. Endocrine, 83(3), 798\u2013809. https:\/\/doi.org\/10.1007\/s12020-023-03594-2","DOI":"10.1007\/s12020-023-03594-2"},{"key":"10082_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cotox.2021.04.004","volume":"27","author":"I Suhani","year":"2021","unstructured":"Suhani, I., Sahab, S., Srivastava, V., & Singh, R. P. (2021). Impact of cadmium pollution on food safety and human health. Current Opinion in Toxicology, 27, 1\u20137. https:\/\/doi.org\/10.1016\/j.cotox.2021.04.004","journal-title":"Current Opinion in Toxicology"},{"key":"10082_CR4","doi-asserted-by":"publisher","unstructured":"Rasin, P., V, A. A., Basheer, S. M., Haribabu, J., Santibanez, J. F., Garrote, C. A., \u2026 & Mangalaraja, R. V. (2025). Exposure to cadmium and its impacts on human health: A short review. Journal of Hazardous Materials Advances, 17, 100608. https:\/\/doi.org\/10.1016\/j.hazadv.2025.100608","DOI":"10.1016\/j.hazadv.2025.100608"},{"key":"10082_CR5","doi-asserted-by":"publisher","unstructured":"Gerzen, O., Tzybina, A., Nabiev, S., Potoskueva, I., Stukalova, N., Votinova, V., \u2026 & Nikitina, L. (2025). Molecular basis of cadmium Cardiotoxicity: Chamber-Specific effects of CdO nanoparticles and soluble CdCl2 exposure. Food and Chemical Toxicology, 204, 115673. https:\/\/doi.org\/10.1016\/j.fct.2025.115673","DOI":"10.1016\/j.fct.2025.115673"},{"issue":"2","key":"10082_CR6","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s12012-024-09955-1","volume":"25","author":"L Liu","year":"2025","unstructured":"Liu, L., Xu, A., & Cheung, B. M. Y. (2025). Associations between lead and cadmium exposure and subclinical cardiovascular disease in U.S. adults. Cardiovascular Toxicology, 25(2), 282\u2013293. https:\/\/doi.org\/10.1007\/s12012-024-09955-1","journal-title":"Cardiovascular Toxicology"},{"issue":"6","key":"10082_CR7","doi-asserted-by":"publisher","first-page":"14959","DOI":"10.1007\/s11356-022-23017-5","volume":"30","author":"S Cui","year":"2022","unstructured":"Cui, S., Wang, Z., Li, X., Wang, H., Wang, H., & Chen, W. (2022). A comprehensive assessment of heavy metal(loid) contamination in leafy vegetables grown in two mining areas in Yunnan, China\u2014a focus on bioaccumulation of cadmium in Malabar spinach. Environmental Science and Pollution Research, 30(6), 14959\u201314974. https:\/\/doi.org\/10.1007\/s11356-022-23017-5","journal-title":"Environmental Science and Pollution Research"},{"key":"10082_CR8","doi-asserted-by":"publisher","unstructured":"Wang, R., Sang, P., Guo, Y., Jin, P., Cheng, Y., Yu, H., \u2026 & Qian, H. (2023). Cadmium in food: Source, distribution and removal. Food Chemistry, 405, 134666. https:\/\/doi.org\/10.1016\/j.foodchem.2022.134666","DOI":"10.1016\/j.foodchem.2022.134666"},{"key":"10082_CR9","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-031-47390-6_1","volume-title":"Cadmium Toxicity Mitigation","author":"S Ullah","year":"2024","unstructured":"Ullah, S., Javed, S., Akhtar, N., Shoukat, L., & Chatha, S. A. S. (2024). The Cadmium in Soil and Plants. In A. K. Jha & N. Kumar (Eds.), Cadmium Toxicity Mitigation (pp. 3\u201329). Springer Nature Switzerland. https:\/\/doi.org\/10.1007\/978-3-031-47390-6_1"},{"key":"10082_CR10","doi-asserted-by":"publisher","unstructured":"Ankush, Ritambhara, Lamba, S., Deepika, & Prakash, R. (2024). Cadmium in Environment\u2014An Overview. In A. K. Jha & N. Kumar (Eds.), Cadmium Toxicity in Water (pp. 3\u201320). Springer Nature Switzerland. https:\/\/doi.org\/10.1007\/978-3-031-54005-9_1","DOI":"10.1007\/978-3-031-54005-9_1"},{"issue":"12","key":"10082_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12120875","volume":"12","author":"S Davidova","year":"2024","unstructured":"Davidova, S., Milushev, V., & Satchanska, G. (2024). The mechanisms of cadmium toxicity in living organisms. Toxics, 12(12), Article 875. https:\/\/doi.org\/10.3390\/toxics12120875","journal-title":"Toxics"},{"key":"10082_CR12","doi-asserted-by":"publisher","unstructured":"Hogervorst, J., Plusquin, M., Vangronsveld, J., Nawrot, T., Cuypers, A., Van Hecke, E., \u2026 & Staessen, J. A. (2007). House dust as possible route of environmental exposure to cadmium and lead in the adult general population. Environmental Research, 103(1), 30\u201337. https:\/\/doi.org\/10.1016\/j.envres.2006.05.009","DOI":"10.1016\/j.envres.2006.05.009"},{"issue":"11","key":"10082_CR13","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1007\/s10653-020-00632-0","volume":"42","author":"OE Orisakwe","year":"2020","unstructured":"Orisakwe, O. E., Udowelle, N. A., Azuonwu, O., Nkeiruka, I. Z., Nkereuwem, U. A., & Frazzoli, C. (2020). Cadmium and lead in geophagic clay consumed in Southern Nigeria: Health risk from such traditional nutraceutical. Environmental Geochemistry and Health, 42(11), 3865\u20133875. https:\/\/doi.org\/10.1007\/s10653-020-00632-0","journal-title":"Environmental Geochemistry and Health"},{"issue":"8013","key":"10082_CR14","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/S0140-6736(77)92117-1","volume":"309","author":"K \u00d8stergaard","year":"1977","unstructured":"\u00d8stergaard, K. (1977). Cadmium and hypertension. Lancet, 309(8013), 677\u2013678. https:\/\/doi.org\/10.1016\/S0140-6736(77)92117-1","journal-title":"Lancet"},{"issue":"1","key":"10082_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0041-008X(85)90098-5","volume":"80","author":"IS Jamall","year":"1985","unstructured":"Jamall, I. S., & Crispin Smith, J. (1985). Effects of cadmium on glutathione peroxidase, superoxide dismutase, and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity. Toxicology and Applied Pharmacology, 80(1), 33\u201342. https:\/\/doi.org\/10.1016\/0041-008X(85)90098-5","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"1\u20132","key":"10082_CR16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3109\/10641969909068651","volume":"21","author":"VN Puri","year":"1999","unstructured":"Puri, V. N. (1999). Cadmium induced hypertension. Clinical and Experimental Hypertension, 21(1\u20132), 79\u201384. https:\/\/doi.org\/10.3109\/10641969909068651","journal-title":"Clinical and Experimental Hypertension"},{"issue":"1","key":"10082_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s12012-010-9092-9","volume":"11","author":"R Mukherjee","year":"2011","unstructured":"Mukherjee, R., Banerjee, S., Joshi, N., Singh, P. K., Baxi, D., & Ramachandran, A. V. (2011). A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage. Cardiovascular Toxicology, 11(1), 78\u201388. https:\/\/doi.org\/10.1007\/s12012-010-9092-9","journal-title":"Cardiovascular Toxicology"},{"key":"10082_CR18","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.envres.2018.11.009","volume":"169","author":"JM Madrigal","year":"2019","unstructured":"Madrigal, J. M., Ricardo, A. C., Persky, V., & Turyk, M. (2019). Associations between blood cadmium concentration and kidney function in the U.S. population: Impact of sex, diabetes and hypertension. Environmental Research, 169, 180\u2013188. https:\/\/doi.org\/10.1016\/j.envres.2018.11.009","journal-title":"Environmental Research"},{"key":"10082_CR19","doi-asserted-by":"publisher","unstructured":"Aramjoo, H., Arab-Zozani, M., Feyzi, A., Naghizadeh, A., Aschner, M., Naimabadi, A., \u2026 & Samarghandian, S. (2022). The association between environmental cadmium exposure, blood pressure, and hypertension: a systematic review and meta-analysis. Environmental Science and Pollution Research, 29(24), 35682\u201335706. https:\/\/doi.org\/10.1007\/s11356-021-17777-9","DOI":"10.1007\/s11356-021-17777-9"},{"key":"10082_CR20","doi-asserted-by":"publisher","unstructured":"Shrivastav, A., Swetanshu, & Singh, P. (2024). The Impact of Environmental Toxins on Cardiovascular Diseases. Current Problems in Cardiology, 49(1), 102120. https:\/\/doi.org\/10.1016\/j.cpcardiol.2023.102120","DOI":"10.1016\/j.cpcardiol.2023.102120"},{"key":"10082_CR21","doi-asserted-by":"publisher","unstructured":"Martins, A. C., Almeida Lopes, A. C. B., Urbano, M. R., Carvalho, M. D. F. H., Silva, A. M. R., Tinkov, A. A., \u2026 & Paoliello, M. M. B. (2021). An updated systematic review on the association between Cd exposure, blood pressure and hypertension. Ecotoxicology and Environmental Safety, 208, 111636. https:\/\/doi.org\/10.1016\/j.ecoenv.2020.111636","DOI":"10.1016\/j.ecoenv.2020.111636"},{"issue":"3","key":"10082_CR22","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/S0946-672X(11)80038-6","volume":"9","author":"S Sarkar","year":"1995","unstructured":"Sarkar, S., Yadav, P., Trivedi, R., Bansal, A. K., & Bhatnagar, D. (1995). Cadmium-induced lipid peroxidation and the status of the antioxidant system in rat tissues. Journal of Trace Elements in Medicine and Biology, 9(3), 144\u2013149. https:\/\/doi.org\/10.1016\/S0946-672X(11)80038-6","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"issue":"14","key":"10082_CR23","doi-asserted-by":"publisher","first-page":"17184","DOI":"10.1007\/s11356-020-08306-1","volume":"27","author":"F Mumtaz","year":"2020","unstructured":"Mumtaz, F., Albeltagy, R. S., Diab, M. S. M., Abdel Moneim, A. E., & El-Habit, O. H. (2020). Exposure to arsenite and cadmium induces organotoxicity and miRNAs deregulation in male rats. Environmental Science and Pollution Research, 27(14), 17184\u201317193. https:\/\/doi.org\/10.1007\/s11356-020-08306-1","journal-title":"Environmental Science and Pollution Research"},{"issue":"4","key":"10082_CR24","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1007\/s12011-024-04307-0","volume":"203","author":"B Yang","year":"2025","unstructured":"Yang, B., Wang, Z., Wang, S., & Li, X. (2025). Unveiling the hub genes involved in cadmium-induced hepatotoxicity. Biological Trace Element Research, 203(4), 2186\u20132205. https:\/\/doi.org\/10.1007\/s12011-024-04307-0","journal-title":"Biological Trace Element Research"},{"issue":"8","key":"10082_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13080611","volume":"13","author":"Y Yaz\u011fan","year":"2025","unstructured":"Yaz\u011fan, Y., Kele\u015f, \u00d6. F., Bayir, M. H., \u00c7i\u00e7ek, H. A., Ahlatc\u0131, A., & Y\u0131ld\u0131zhan, K. (2025). Selenium reduces cadmium-induced cardiotoxicity by modulating oxidative stress and the ROS\/PARP-1\/TRPM2 signalling pathway in rats. Toxics, 13(8), Article 611. https:\/\/doi.org\/10.3390\/toxics13080611","journal-title":"Toxics"},{"key":"10082_CR26","doi-asserted-by":"publisher","unstructured":"Hanan K. Alghibiwi, Ahlam M. Alhusiani, Wedad S. Sarawi, Laila Fadda, Hatun A. Alomar, Juman S. Alsaab, \u2026 Samiah Alhabardi. (2025). Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4\/NF-\u03baB signaling and necroptosis in rats. Cellular and Molecular Biology, 71(1), 118\u2013124. https:\/\/doi.org\/10.14715\/cmb\/2025.70.1.13","DOI":"10.14715\/cmb\/2025.70.1.13"},{"issue":"1","key":"10082_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-11473-1","volume":"15","author":"A Mukherjee","year":"2025","unstructured":"Mukherjee, A., Vankamamidi, S. E., & Ks, M. (2025). Probing the microRNA landscape in cadmium chloride induced renal toxicity through an in silico approach. Scientific Reports, 15(1), Article 25251. https:\/\/doi.org\/10.1038\/s41598-025-11473-1","journal-title":"Scientific Reports"},{"key":"10082_CR28","doi-asserted-by":"publisher","unstructured":"Zhao, M., Gu, S., Liu, T., Gao, S., Qiao, Z., Wang, K., \u2026 & He, J. (2025). Association Between Urinary Metals and Polycyclic Aromatic Hydrocarbon Levels and Cardiovascular Disease Among Adult Americans: Data from NHANES 2011 to 2016. Cardiovascular Toxicology, 25(7), 929\u2013943. https:\/\/doi.org\/10.1007\/s12012-025-10009-3","DOI":"10.1007\/s12012-025-10009-3"},{"issue":"5","key":"10082_CR29","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/BF00293629","volume":"62","author":"U Wormser","year":"1988","unstructured":"Wormser, U., & Nir, I. (1988). Effect of age on cadmium-induced metallothionein synthesis in the rat. Archives of Toxicology, 62(5), 392\u2013394. https:\/\/doi.org\/10.1007\/BF00293629","journal-title":"Archives of Toxicology"},{"key":"10082_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-025-01322-3","author":"G Fatima","year":"2025","unstructured":"Fatima, G., Raza, A. M., & Dhole, P. (2025). Heavy metal exposure and its health implications: A comprehensive review. Indian Journal of Clinical Biochemistry. https:\/\/doi.org\/10.1007\/s12291-025-01322-3","journal-title":"Indian Journal of Clinical Biochemistry"},{"issue":"1","key":"10082_CR31","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00204-024-03903-2","volume":"99","author":"K Jomova","year":"2025","unstructured":"Jomova, K., Alomar, S. Y., Nepovimova, E., Kuca, K., & Valko, M. (2025). Heavy metals: Toxicity and human health effects. Archives of Toxicology, 99(1), 153\u2013209. https:\/\/doi.org\/10.1007\/s00204-024-03903-2","journal-title":"Archives of Toxicology"},{"key":"10082_CR32","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1289\/ehp.845451","volume":"54","author":"K Kostial","year":"1984","unstructured":"Kostial, K. (1984). Effect of age and diet on renal cadmium retention in rats. Environmental Health Perspectives, 54, 51\u201356.","journal-title":"Environmental Health Perspectives"},{"key":"10082_CR33","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1289\/ehp.782581","volume":"25","author":"K Kostial","year":"1978","unstructured":"Kostial, K., Kello, D., Jugo, S., Rabar, I., & Maljkovi\u0107, T. (1978). Influence of age on metal metabolism and toxicity. Environmental Health Perspectives, 25, 81\u201386.","journal-title":"Environmental Health Perspectives"},{"issue":"1","key":"10082_CR34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1039\/a705136k","volume":"123","author":"A Oskarsson","year":"1998","unstructured":"Oskarsson, A., Hall\u00e9n, I. P., Sundberg, J., & Graw\u00e9, K. P. (1998). Risk assessment in relation to neonatal metal exposure. Analyst, 123(1), 19\u201323.","journal-title":"Analyst"},{"key":"10082_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2025.127631","volume":"89","author":"Z Chenjin","year":"2025","unstructured":"Chenjin, Z. (2025). Exposure assessments of cadmium and lead with age-related eye disease: A systematic review and meta-analysis. Journal of Trace Elements in Medicine and Biology, 89, Article 127631. https:\/\/doi.org\/10.1016\/j.jtemb.2025.127631","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"10082_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2025.144194","volume":"374","author":"S-W Ryoo","year":"2025","unstructured":"Ryoo, S.-W., Choi, B.-Y., Son, S.-Y., Lee, J.-H., Min, J.-Y., & Min, K.-B. (2025). Lead and cadmium exposure was associated with faster epigenetic aging in a representative sample of adults aged 50 and older in the United States. Chemosphere, 374, Article 144194. https:\/\/doi.org\/10.1016\/j.chemosphere.2025.144194","journal-title":"Chemosphere"},{"issue":"2","key":"10082_CR37","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/15376516.2024.2399779","volume":"35","author":"AFA Dawood","year":"2025","unstructured":"Dawood, A. F. A., Alharbi, H. M., Ismaeel, F. I., Khan, S. M., Yassa, H. D., Welson, N. N., & Abd El-Aziz, F.E.-Z.A. (2025). Cadmium-induced pancreatic toxicity in rats: Comparing vitamin C and Nigella sativa as protective agents: A histomorphometric and ultrastructural study. Toxicology Mechanisms and Methods, 35(2), 181\u2013196. https:\/\/doi.org\/10.1080\/15376516.2024.2399779","journal-title":"Toxicology Mechanisms and Methods"},{"key":"10082_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118749","volume":"302","author":"NM El Bakary","year":"2025","unstructured":"El Bakary, N. M., Abdelhamid, G. R., Anees, L. M., & Rihan, S. (2025). Resveratrol mitigates cadmium chloride-induced cardiotoxicity in rats via AMPK-mediated signaling: The modulatory role of low-dose gamma radiation. Ecotoxicology and Environmental Safety, 302, Article 118749. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.118749","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"10082_CR39","doi-asserted-by":"publisher","unstructured":"Oladele, J. O., Ajayi, E. I. O., Babatunde, I. O., Awosanya, O. O., Oladele, O. T., Atolagbe, O. S., \u2026 & Oyeleke, O. M. (2025). Neuroprotective efficacy of Talinum triangulare in Cadmium-induced neurotoxicity: involvement of antioxidant defense, anti-inflammatory, dopaminergic, and cholinergic systems. Metabolic Brain Disease, 40(6), 237. https:\/\/doi.org\/10.1007\/s11011-025-01655-1","DOI":"10.1007\/s11011-025-01655-1"},{"key":"10082_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2025.127614","volume":"88","author":"N Barakat","year":"2025","unstructured":"Barakat, N., Alkhen, M. A., Khater, Y., & Khirallah, S. M. (2025). Effect of Melatonin and Ginseng on rat testis and sperm quality against cadmium toxicity via inhibiting oxidative stress and autophagy pathways. Journal of Trace Elements in Medicine and Biology, 88, Article 127614. https:\/\/doi.org\/10.1016\/j.jtemb.2025.127614","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"10082_CR41","doi-asserted-by":"publisher","unstructured":"Anyachor, C. P., Orisakwe, O. E., Orish, C. N., Parisi, C., Vangone, R., Guerretti, V., \u2026 & Guerriero, G. (2025). Testis metal toxicity remediation by agro-food waste: evidence of a protective effect of melon seed husk extract Cucumeropsis mannii silica nanoparticles on gonadotropin and sex steroid hormones. Environmental Science and Pollution Research, 32(10), 6172\u20136184. https:\/\/doi.org\/10.1007\/s11356-025-36106-y","DOI":"10.1007\/s11356-025-36106-y"},{"key":"10082_CR42","doi-asserted-by":"publisher","unstructured":"Abdel-Gawad, F. Kh., Khalil, W. K. B., Bassem, S. M., Kumar, V., Parisi, C., Inglese, S., \u2026 & Guerriero, G. (2020). The Duckweed, Lemna minor Modulates Heavy Metal-Induced Oxidative Stress in the Nile Tilapia, Oreochromis niloticus. Water, 12(11), 2983. https:\/\/doi.org\/10.3390\/w12112983","DOI":"10.3390\/w12112983"},{"issue":"8","key":"10082_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/biom15081083","volume":"15","author":"GF Nordberg","year":"2025","unstructured":"Nordberg, G. F., & Nordberg, M. (2025). Metallothionein and Other Factors Influencing Cadmium-Induced Kidney Dysfunction: Review and Commentary. Biomolecules, 15(8), Article 1083. https:\/\/doi.org\/10.3390\/biom15081083","journal-title":"Biomolecules"},{"key":"10082_CR44","doi-asserted-by":"publisher","unstructured":"Shen, X., Liu, W., Chen, Y., Guo, Y., Gao, M., Chen, W., \u2026 & Liu, S. (2019). Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure. Chemosphere, 229, 32\u201340. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.04.192","DOI":"10.1016\/j.chemosphere.2019.04.192"},{"key":"10082_CR45","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-025-04803-x","author":"Y Liang","year":"2025","unstructured":"Liang, Y., Shi, Y., Su, Q., Gu, C., & Wu, R. (2025). Zinc attenuates cadmium and high-fat diet-induced cardiomyopathy by enhancing metallothionein-mediated cardiac protection. Biological Trace Element Research. https:\/\/doi.org\/10.1007\/s12011-025-04803-x","journal-title":"Biological Trace Element Research"},{"key":"10082_CR46","doi-asserted-by":"publisher","unstructured":"Huang, S., Wang, J., Men, H., Tan, Y., Lin, Q., Gozal, E., \u2026 & Cai, L. (2021). Cardiac metallothionein overexpression rescues diabetic cardiomyopathy in Akt2-knockout mice. Journal of Cellular and Molecular Medicine, 25(14), 6828\u20136840. https:\/\/doi.org\/10.1111\/jcmm.16687","DOI":"10.1111\/jcmm.16687"},{"issue":"1","key":"10082_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-025-00482-x","volume":"12","author":"H Lu","year":"2025","unstructured":"Lu, H., Delnicki, M., Griffin, G., & Wise, J. L. (2025). Current understanding of sex differences in metal-induced diseases. Current Environmental Health Reports, 12(1), Article 18. https:\/\/doi.org\/10.1007\/s40572-025-00482-x","journal-title":"Current Environmental Health Reports"},{"key":"10082_CR48","doi-asserted-by":"publisher","unstructured":"Fitch, M. L., Kabir, R., Ebenebe, O. V., Taube, N., Garbus, H., Sinha, P., \u2026 & Kohr, M. J. (2023). Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function. Life Sciences, 324, 121712. https:\/\/doi.org\/10.1016\/j.lfs.2023.121712","DOI":"10.1016\/j.lfs.2023.121712"},{"key":"10082_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116247","volume":"454","author":"J Huang","year":"2022","unstructured":"Huang, J., El-Kersh, K., Mann, K. K., James, K. A., & Cai, L. (2022). Overview of the cardiovascular effects of environmental metals: New preclinical and clinical insights. Toxicology and Applied Pharmacology, 454, Article 116247. https:\/\/doi.org\/10.1016\/j.taap.2022.116247","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"2","key":"10082_CR50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3109\/01480545.2011.589450","volume":"35","author":"PK Singh","year":"2012","unstructured":"Singh, P. K., Baxi, D., Diwedi, R., & Ramachandran, A. V. (2012). Prior cadmium exposure improves glucoregulation in diabetic rats but exacerbates effects on metabolic dysregulation, oxidative stress, and hepatic and renal toxicity. Drug and Chemical Toxicology, 35(2), 167\u2013177. https:\/\/doi.org\/10.3109\/01480545.2011.589450","journal-title":"Drug and Chemical Toxicology"},{"key":"10082_CR51","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.biopha.2016.12.098","volume":"87","author":"LB Priya","year":"2017","unstructured":"Priya, L. B., Baskaran, R., Elangovan, P., Dhivya, V., Huang, C.-Y., & Padma, V. V. (2017). Tinospora cordifolia extract attenuates cadmium-induced biochemical and histological alterations in the heart of male Wistar rats. Biomedicine & Pharmacotherapy, 87, 280\u2013287. https:\/\/doi.org\/10.1016\/j.biopha.2016.12.098","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"10082_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29504-0","volume":"13","author":"Z Kong","year":"2023","unstructured":"Kong, Z., Liu, C., & Olatunji, O. J. (2023). Asperuloside attenuates cadmium-induced toxicity by inhibiting oxidative stress, inflammation, fibrosis and apoptosis in rats. Scientific Reports, 13(1), Article 5698. https:\/\/doi.org\/10.1038\/s41598-023-29504-0","journal-title":"Scientific Reports"},{"issue":"1","key":"10082_CR53","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s12011-024-04162-z","volume":"203","author":"A Kumar","year":"2025","unstructured":"Kumar, A., & Sharma, B. (2025). Cardioprotective effect of eugenol against Cd-induced inflammation, oxidative stress, and dyslipidemia in male rats: An in vivo and molecular docking study. Biological Trace Element Research, 203(1), 261\u2013279. https:\/\/doi.org\/10.1007\/s12011-024-04162-z","journal-title":"Biological Trace Element Research"},{"issue":"4","key":"10082_CR54","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s12012-018-9446-2","volume":"18","author":"M Goudarzi","year":"2018","unstructured":"Goudarzi, M., Fatemi, I., Siahpoosh, A., Sezavar, S. H., Mansouri, E., & Mehrzadi, S. (2018). Protective effect of ellagic acid against sodium arsenite-induced cardio- and hematotoxicity in rats. Cardiovascular Toxicology, 18(4), 337\u2013345. https:\/\/doi.org\/10.1007\/s12012-018-9446-2","journal-title":"Cardiovascular Toxicology"},{"issue":"2","key":"10082_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2025.100788","volume":"5","author":"M Khattak","year":"2025","unstructured":"Khattak, M., Khan, I. A., Shah, N., Abdulsamad, S. A., Naeem, A. A., & Shah, A. J. (2025). Shikimic acid, a phenolic acid reverses isoproterenol-induced myocardial infarction in rat model. Phytomedicine Plus, 5(2), Article 100788. https:\/\/doi.org\/10.1016\/j.phyplu.2025.100788","journal-title":"Phytomedicine Plus"},{"issue":"1","key":"10082_CR56","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0300-483X(82)90037-3","volume":"23","author":"S Onosaka","year":"1982","unstructured":"Onosaka, S., & Cherian, M. G. (1982). The induced synthesis of metallothionein in various tissues of rats in response to metals. II. Influence of zinc status and specific effect on pancreatic metallothionein. Toxicology, 23(1), 11\u201320. https:\/\/doi.org\/10.1016\/0300-483X(82)90037-3","journal-title":"Toxicology"},{"key":"10082_CR57","doi-asserted-by":"crossref","unstructured":"Buege, J. A., & Aust, S. D. (1978). [30] Microsomal lipid peroxidation. In Methods in enzymology (Vol. 52, pp. 302\u2013310). Elsevier.","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"10082_CR58","first-page":"882","volume":"61","author":"E Beutler","year":"1963","unstructured":"Beutler, E., Duron, O., & Kelly, B. M. (1963). Improved method for the determination of blood glutathione. The Journal of laboratory and clinical medicine, 61, 882\u2013888.","journal-title":"The Journal of laboratory and clinical medicine"},{"key":"10082_CR59","doi-asserted-by":"publisher","unstructured":"Omaye, S. T., Turnbull, J. D., & Sauberlich, H. E. (1979). [1] Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids (pp. 3\u201311). https:\/\/doi.org\/10.1016\/0076-6879(79)62181-X","DOI":"10.1016\/0076-6879(79)62181-X"},{"issue":"3","key":"10082_CR60","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund, S., & Marklund, G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47(3), 469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"European Journal of Biochemistry"},{"issue":"2","key":"10082_CR61","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","volume":"47","author":"AK Sinha","year":"1972","unstructured":"Sinha, A. K. (1972). Colorimetric assay of catalase. Analytical Biochemistry, 47(2), 389\u2013394. https:\/\/doi.org\/10.1016\/0003-2697(72)90132-7","journal-title":"Analytical Biochemistry"},{"issue":"4073","key":"10082_CR62","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1126\/science.179.4073.588","volume":"179","author":"JT Rotruck","year":"1973","unstructured":"Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., & Hoekstra, W. G. (1973). Selenium: Biochemical role as a component of glutathione peroxidase. Science, 179(4073), 588\u2013590. https:\/\/doi.org\/10.1126\/science.179.4073.588","journal-title":"Science"},{"issue":"3","key":"10082_CR63","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1080\/15321819.2011.559391","volume":"32","author":"TG Shrivastav","year":"2011","unstructured":"Shrivastav, T. G., Chaube, S. K., Kariya, K. P., Rangari, K., & Singh, R. (2011). Development of an antigen heterologous enzyme linked immunosorbent assay for Measurement of corticosterone in rat serum. Journal of Immunoassay & Immunochemistry, 32(3), 244\u2013257.","journal-title":"Journal of Immunoassay & Immunochemistry"},{"key":"10082_CR64","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.fertnstert.2005.03.073","volume":"84","author":"SK Chaube","year":"2005","unstructured":"Chaube, S. K., Prasad, P. V., Thakur, S. C., & Shrivastav, T. G. (2005). Estradiol protects clomiphene citrate\u2013induced apoptosis in ovarian follicular cells and ovulated cumulus\u2013oocyte complexes. Fertility and Sterility, 84, 1163\u20131172.","journal-title":"Fertility and Sterility"},{"key":"10082_CR65","doi-asserted-by":"publisher","unstructured":"D. Roberts, M., C. Young, K., D. Fox, C., G. Vann, C., A. Roberson, P., C. Osburn, S., \u2026 & N. Kavazis, A. (2020). An optimized procedure for isolation of rodent and human skeletal muscle sarcoplasmic and myofibrillar proteins. Journal of Biological Methods, 7(1), 1. https:\/\/doi.org\/10.14440\/jbm.2020.307","DOI":"10.14440\/jbm.2020.307"},{"issue":"3","key":"10082_CR66","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.lfs.2007.05.010","volume":"81","author":"VV Dhote","year":"2007","unstructured":"Dhote, V. V., & Balaraman, R. (2007). Gender specific effect of progesterone on myocardial ischemia\/reperfusion injury in rats. Life Sciences, 81(3), 188\u2013197.","journal-title":"Life Sciences"},{"issue":"3","key":"10082_CR67","doi-asserted-by":"publisher","DOI":"10.3390\/biom12030360","volume":"12","author":"M Nordberg","year":"2022","unstructured":"Nordberg, M., & Nordberg, G. F. (2022). Metallothionein and cadmium toxicology\u2014Historical review and commentary. Biomolecules, 12(3), Article 360. https:\/\/doi.org\/10.3390\/biom12030360","journal-title":"Biomolecules"},{"key":"10082_CR68","doi-asserted-by":"publisher","unstructured":"Nizam, H., Imtiaz, A., Tasneem, F., Shakoori, F. R., Zulfiqar, S., Younas, A., \u2026 & Shakoori, A. R. (2025). Enhanced cadmium binding ability in response to novel modifications in a Paramecium cadmium metallothionein PMCd1. PLoS One, 20(5), e0324322. https:\/\/doi.org\/10.1371\/journal.pone.0324322","DOI":"10.1371\/journal.pone.0324322"},{"key":"10082_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphys.2023.111841","volume":"568","author":"Y Matsuura","year":"2023","unstructured":"Matsuura, Y. (2023). First principles study of coherent electron\/spin transport across metallothionein: A cadmium-binding protein. Chemical Physics, 568, Article 111841. https:\/\/doi.org\/10.1016\/j.chemphys.2023.111841","journal-title":"Chemical Physics"},{"key":"10082_CR70","doi-asserted-by":"publisher","unstructured":"Oshima, Y., Fujio, Y., Nakanishi, T., Itoh, N., Yamamoto, Y., Negoro, S., \u2026 & Azuma, J. (2005). STAT3 mediates cardioprotection against ischemia\/reperfusion injury through metallothionein induction in the heart. Cardiovascular Research, 65(2), 428\u2013435. https:\/\/doi.org\/10.1016\/j.cardiores.2004.10.021","DOI":"10.1016\/j.cardiores.2004.10.021"},{"issue":"3","key":"10082_CR71","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1046\/j.1525-1373.1999.d01-143.x","volume":"222","author":"YJ Kang","year":"1999","unstructured":"Kang, Y. J. (1999). The antioxidant function of metallothionein in the heart. Proceedings of the Society for Experimental Biology and Medicine (New York, N.Y.), 222(3), 263\u2013273. https:\/\/doi.org\/10.1046\/j.1525-1373.1999.d01-143.x","journal-title":"Proceedings of the Society for Experimental Biology and Medicine (New York, N.Y.)"},{"issue":"6","key":"10082_CR72","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1172\/JCI119672","volume":"100","author":"YJ Kang","year":"1997","unstructured":"Kang, Y. J., Chen, Y., Yu, A., Voss-McCowan, M., & Epstein, P. N. (1997). Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. Journal of Clinical Investigation, 100(6), 1501\u20131506. https:\/\/doi.org\/10.1172\/JCI119672","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"10082_CR73","doi-asserted-by":"publisher","first-page":"H993","DOI":"10.1152\/ajpheart.1999.276.3.H993","volume":"276","author":"YJ Kang","year":"1999","unstructured":"Kang, Y. J., Li, G., & Saari, J. T. (1999). Metallothionein inhibits ischemia-reperfusion injury in mouse heart. American Journal of Physiology-Heart and Circulatory Physiology, 276(3), H993\u2013H997. https:\/\/doi.org\/10.1152\/ajpheart.1999.276.3.H993","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10082_CR74","doi-asserted-by":"publisher","unstructured":"Xue, M., Joo, Y. A., Li, S., Niu, C., Chen, G., Yi, X., \u2026 & Cong, W. (2019). Metallothionein Protects the Heart Against Myocardial Infarction via the mTORC2\/FoxO3a\/Bim Pathway. Antioxidants & Redox Signaling, 31(5), 403\u2013419. https:\/\/doi.org\/10.1089\/ars.2018.7597","DOI":"10.1089\/ars.2018.7597"},{"key":"10082_CR75","doi-asserted-by":"publisher","unstructured":"Liu, Y., Shen, M., Zhu, S., Du, Z., Lin, L., Ma, J., \u2026 & Lu, Q. (2025). Metallothionein rescues doxorubicin cardiomyopathy via mitigation of cuproptosis. Life Sciences, 363, 123379. https:\/\/doi.org\/10.1016\/j.lfs.2025.123379","DOI":"10.1016\/j.lfs.2025.123379"},{"key":"10082_CR76","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cotox.2020.01.004","volume":"19","author":"\u00c7 Sevim","year":"2020","unstructured":"Sevim, \u00c7., Do\u011fan, E., & Comakli, S. (2020). Cardiovascular disease and toxic metals. Current Opinion in Toxicology, 19, 88\u201392. https:\/\/doi.org\/10.1016\/j.cotox.2020.01.004","journal-title":"Current Opinion in Toxicology"},{"issue":"2","key":"10082_CR77","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0742-8413(95)02077-2","volume":"113","author":"G Roesijadi","year":"1996","unstructured":"Roesijadi, G. (1996). Metallothionein and its role in toxic metal regulation. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 113(2), 117\u2013123. https:\/\/doi.org\/10.1016\/0742-8413(95)02077-2","journal-title":"Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology"},{"issue":"1","key":"10082_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0024-3205(78)90317-X","volume":"23","author":"M George Cherian","year":"1978","unstructured":"George Cherian, M., & Goyer, R. A. (1978). Metallothioneins and their role in the metabolism and toxicity of metals. Life Sciences, 23(1), 1\u20139. https:\/\/doi.org\/10.1016\/0024-3205(78)90317-X","journal-title":"Life Sciences"},{"issue":"4","key":"10082_CR79","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jtemb.2005.10.006","volume":"19","author":"E Chwe\u0142atiuk","year":"2006","unstructured":"Chwe\u0142atiuk, E., W\u0142ostowski, T., Krasowska, A., & Bonda, E. (2006). The effect of orally administered melatonin on tissue accumulation and toxicity of cadmium in mice. Journal of Trace Elements in Medicine and Biology, 19(4), 259\u2013265. https:\/\/doi.org\/10.1016\/j.jtemb.2005.10.006","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"10082_CR80","doi-asserted-by":"publisher","unstructured":"Jing, L., Yang, M., Li, Y., Yu, Y., Liang, B., Cao, L., \u2026 & Sun, Z. (2017). Metallothionein prevents doxorubicin cardiac toxicity by indirectly regulating the uncoupling proteins 2. Food and Chemical Toxicology, 110, 204\u2013213. https:\/\/doi.org\/10.1016\/j.fct.2017.10.035","DOI":"10.1016\/j.fct.2017.10.035"},{"issue":"1","key":"10082_CR81","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/6197553","volume":"2024","author":"OE Ezim","year":"2024","unstructured":"Ezim, O. E., Kidi, L., Ndufeiya-Kumasi, L. C., & Abarikwu, S. O. (2024). Iron administration partially ameliorates cadmium-induced oxidative damage in the liver and kidney of rats. Journal of Toxicology, 2024(1), Article 6197553. https:\/\/doi.org\/10.1155\/2024\/6197553","journal-title":"Journal of Toxicology"},{"issue":"2\u20133","key":"10082_CR82","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0300-483X(03)00305-6","volume":"192","author":"M Waisberg","year":"2003","unstructured":"Waisberg, M., Joseph, P., Hale, B., & Beyersmann, D. (2003). Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology, 192(2\u20133), 95\u2013117. https:\/\/doi.org\/10.1016\/S0300-483X(03)00305-6","journal-title":"Toxicology"},{"issue":"3","key":"10082_CR83","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.ijcard.2003.10.025","volume":"97","author":"B Sievers","year":"2004","unstructured":"Sievers, B., John, B., Brandts, B., Franken, U., Van Bracht, M., & Trappe, H.-J. (2004). How reliable is electrocardiography in differentiating transmural from non-transmural myocardial infarction? A study with contrast magnetic resonance imaging as gold standard. International Journal of Cardiology, 97(3), 417\u2013423. https:\/\/doi.org\/10.1016\/j.ijcard.2003.10.025","journal-title":"International Journal of Cardiology"},{"issue":"2","key":"10082_CR84","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s00335-023-09977-0","volume":"34","author":"C Calvet","year":"2023","unstructured":"Calvet, C., & Seebeck, P. (2023). What to consider for ECG in mice\u2014with special emphasis on telemetry. Mammalian Genome, 34(2), 166\u2013179. https:\/\/doi.org\/10.1007\/s00335-023-09977-0","journal-title":"Mammalian Genome"},{"issue":"2\u20133","key":"10082_CR85","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0378-4274(99)00059-4","volume":"106","author":"D Nigam","year":"1999","unstructured":"Nigam, D., Shukla, G. S., & Agarwal, A. K. (1999). Glutathione depletion and oxidative damage in mitochondria following exposure to cadmium in rat liver and kidney. Toxicology Letters, 106(2\u20133), 151\u2013157. https:\/\/doi.org\/10.1016\/S0378-4274(99)00059-4","journal-title":"Toxicology Letters"},{"key":"10082_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1461171","volume":"15","author":"S Saedi","year":"2024","unstructured":"Saedi, S., Tan, Y., Watson, S. E., Wintergerst, K. A., & Cai, L. (2024). Potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes. Frontiers in Endocrinology, 15, Article 1461171. https:\/\/doi.org\/10.3389\/fendo.2024.1461171","journal-title":"Frontiers in Endocrinology"},{"issue":"11","key":"10082_CR87","doi-asserted-by":"publisher","DOI":"10.1289\/EHP11208","volume":"130","author":"X Wu","year":"2022","unstructured":"Wu, X., Chen, Y., Luz, A., Hu, G., & Tokar, E. J. (2022). Cardiac development in the presence of cadmium: An in vitrostudy using human embryonic stem cells and cardiac organoids. Environmental Health Perspectives, 130(11), Article 117002. https:\/\/doi.org\/10.1289\/EHP11208","journal-title":"Environmental Health Perspectives"},{"issue":"1","key":"10082_CR88","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1006\/taap.1998.8575","volume":"154","author":"DA Limaye","year":"1999","unstructured":"Limaye, D. A., & Shaikh, Z. A. (1999). Cytotoxicity of cadmium and characteristics of its transport in cardiomyocytes. Toxicology and Applied Pharmacology, 154(1), 59\u201366. https:\/\/doi.org\/10.1006\/taap.1998.8575","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"12","key":"10082_CR89","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11122468","volume":"11","author":"G Furtak","year":"2022","unstructured":"Furtak, G., Koz\u0142owski, M., Kwiatkowski, S., & Cymbaluk-P\u0142oska, A. (2022). The role of lead and cadmium in gynecological malignancies. Antioxidants, 11(12), Article 2468. https:\/\/doi.org\/10.3390\/antiox11122468","journal-title":"Antioxidants"},{"issue":"3","key":"10082_CR90","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1096\/fasebj.1.3.2887478","volume":"1","author":"RK Singhal","year":"1987","unstructured":"Singhal, R. K., Anderson, M. E., & Meister, A. (1987). Glutathione, a first line of defense against cadmium toxicity. The FASEB Journal, 1(3), 220\u2013223. https:\/\/doi.org\/10.1096\/fasebj.1.3.2887478","journal-title":"The FASEB Journal"},{"issue":"1","key":"10082_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0009-2797(88)90026-9","volume":"65","author":"T Ochi","year":"1988","unstructured":"Ochi, T., Otsuka, F., Takahashi, K., & Ohsawa, M. (1988). Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells. Chemico-Biological Interactions, 65(1), 1\u201314. https:\/\/doi.org\/10.1016\/0009-2797(88)90026-9","journal-title":"Chemico-Biological Interactions"},{"key":"10082_CR92","doi-asserted-by":"publisher","unstructured":"Li, F.-J., Fu, S., Ye, H., Hu, Y.-H., Chen, J., Privratsky, J. R., \u2026 & Ren, J. (2024). Metallothionein Alleviates Glutathione Depletion\u2013Induced Oxidative Cardiomyopathy through CISD1-Dependent Regulation of Ferroptosis in Murine Hearts. The American Journal of Pathology, 194(6), 912\u2013926. https:\/\/doi.org\/10.1016\/j.ajpath.2024.02.009","DOI":"10.1016\/j.ajpath.2024.02.009"},{"key":"10082_CR93","doi-asserted-by":"publisher","unstructured":"Ali-El-Dein, B., Abdelgawad, M., Tarek, M., Abdel-Rahim, M., Elkady, M. E., Saleh, H. H., \u2026 & Stenzl, A. (2025). Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase. Urologic Oncology: Seminars and Original Investigations, 43(3), 190.e11-190.e20. https:\/\/doi.org\/10.1016\/j.urolonc.2024.09.009","DOI":"10.1016\/j.urolonc.2024.09.009"},{"issue":"1","key":"10082_CR94","doi-asserted-by":"publisher","DOI":"10.3390\/medsci10010007","volume":"10","author":"V Poli","year":"2022","unstructured":"Poli, V., Madduru, R., Aparna, Y., Kandukuri, V., & Motireddy, S. R. (2022). Amelioration of cadmium-induced oxidative damage in Wistar rats by vitamin C, zinc and N-acetylcysteine. Medical Sciences, 10(1), Article 7. https:\/\/doi.org\/10.3390\/medsci10010007","journal-title":"Medical Sciences"},{"key":"10082_CR95","doi-asserted-by":"publisher","unstructured":"Antar, S. A., Abdo, W., Helal, A. I., Abduh, M. S., Hakami, Z. H., Germoush, M. O., \u2026 & Mahmoud, A. M. (2024). Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-\u03baB\/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sciences, 348, 122688. https:\/\/doi.org\/10.1016\/j.lfs.2024.122688","DOI":"10.1016\/j.lfs.2024.122688"},{"issue":"1\u20132","key":"10082_CR96","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.mrgentox.2008.09.015","volume":"674","author":"J Lim\u00f3n-Pacheco","year":"2009","unstructured":"Lim\u00f3n-Pacheco, J., & Gonsebatt, M. E. (2009). The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress. Mutation Research\/Genetic Toxicology and Environmental Mutagenesis, 674(1\u20132), 137\u2013147. https:\/\/doi.org\/10.1016\/j.mrgentox.2008.09.015","journal-title":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"},{"key":"10082_CR97","doi-asserted-by":"publisher","unstructured":"Dhakshinamoorthy, S., Long, D. J., & Jaiswal, A. K. (2001). Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens. In Current Topics in Cellular Regulation (Vol. 36, pp. 201\u2013216). Elsevier. https:\/\/doi.org\/10.1016\/S0070-2137(01)80009-1","DOI":"10.1016\/S0070-2137(01)80009-1"},{"issue":"2","key":"10082_CR98","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020312","volume":"11","author":"G Guerriero","year":"2022","unstructured":"Guerriero, G., & D\u2019Errico, G. (2022). Effect of oxidative stress on reproduction and development. Antioxidants, 11(2), Article 312. https:\/\/doi.org\/10.3390\/antiox11020312","journal-title":"Antioxidants"},{"issue":"19","key":"10082_CR99","doi-asserted-by":"publisher","first-page":"18286","DOI":"10.1007\/s11356-017-0098-8","volume":"25","author":"G Guerriero","year":"2018","unstructured":"Guerriero, G., D\u2019Errico, G., Di Giaimo, R., Rabbito, D., Olanrewaju, O. S., & Ciarcia, G. (2018). Reactive oxygen species and glutathione antioxidants in the testis of the soil biosentinel Podarcis sicula (Rafinesque 1810). Environmental Science and Pollution Research, 25(19), 18286\u201318296. https:\/\/doi.org\/10.1007\/s11356-017-0098-8","journal-title":"Environmental Science and Pollution Research"},{"issue":"1\u20132","key":"10082_CR100","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0300-483X(02)00245-7","volume":"179","author":"E Casalino","year":"2002","unstructured":"Casalino, E., Calzaretti, G., Sblano, C., & Landriscina, C. (2002). Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology, 179(1\u20132), 37\u201350. https:\/\/doi.org\/10.1016\/S0300-483X(02)00245-7","journal-title":"Toxicology"},{"key":"10082_CR101","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ecoenv.2017.12.009","volume":"149","author":"AA Fel\u00edcio","year":"2018","unstructured":"Fel\u00edcio, A. A., Freitas, J. S., Scarin, J. B., De Souza Ondei, L., Teresa, F. B., Schlenk, D., & De Almeida, E. A. (2018). Isolated and mixed effects of diuron and its metabolites on biotransformation enzymes and oxidative stress response of Nile tilapia (Oreochromis niloticus). Ecotoxicology and Environmental Safety, 149, 248\u2013256. https:\/\/doi.org\/10.1016\/j.ecoenv.2017.12.009","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"10082_CR102","doi-asserted-by":"publisher","unstructured":"Okonkwo, C. O., Uyang, G. A., & Okonkwo, S. N. (2023). Assessing the Biochemical Implication of using Stachytarpheta cayennensis Essential Oil as an Alternative to Synthetic Pesticides in Calabar Nigeria. https:\/\/doi.org\/10.21203\/rs.3.rs-3664402\/v1","DOI":"10.21203\/rs.3.rs-3664402\/v1"},{"key":"10082_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2020.101889","volume":"111","author":"I Camacho-Abrego","year":"2021","unstructured":"Camacho-Abrego, I., Gonz\u00e1lez-Cano, S. I., Aguilar-Alonso, P., Brambila, E., Cruz, Fdela, & Flores, G. (2021). Changes in nitric oxide, zinc and metallothionein levels in limbic regions at pre-pubertal and post-pubertal ages presented in an animal model of schizophrenia. Journal of Chemical Neuroanatomy, 111, Article 101889. https:\/\/doi.org\/10.1016\/j.jchemneu.2020.101889","journal-title":"Journal of Chemical Neuroanatomy"},{"issue":"11","key":"10082_CR104","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26115155","volume":"26","author":"J Kozak","year":"2025","unstructured":"Kozak, J. (2025). The role of heavy metals in the biology of female cancers. International Journal of Molecular Sciences, 26(11), Article 5155. https:\/\/doi.org\/10.3390\/ijms26115155","journal-title":"International Journal of Molecular Sciences"},{"key":"10082_CR105","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109352","volume":"197","author":"L Wiklund","year":"2025","unstructured":"Wiklund, L., Wincent, E., & Beronius, A. (2025). Using transcriptomics data and Adverse Outcome Pathway networks to explore endocrine disrupting properties of Cadmium and PCB-126. Environment International, 197, Article 109352. https:\/\/doi.org\/10.1016\/j.envint.2025.109352","journal-title":"Environment International"},{"key":"10082_CR106","doi-asserted-by":"publisher","unstructured":"Zhou, H., Chen, X., Tao, Y., Li, Z., Wu, H., Shi, H., \u2026 & Huang, F. (2025). Corticosterone-Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice. Clinical and Experimental Pharmacology and Physiology, 52(4), e70027. https:\/\/doi.org\/10.1111\/1440-1681.70027","DOI":"10.1111\/1440-1681.70027"},{"issue":"1","key":"10082_CR107","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.pharmtox.39.1.267","volume":"39","author":"CD Klaassen","year":"1999","unstructured":"Klaassen, C. D., Liu, J., & Choudhuri, S. (1999). METALLOTHIONEIN: An intracellular protein to protect against cadmium toxicity. Annual Review of Pharmacology and Toxicology, 39(1), 267\u2013294. https:\/\/doi.org\/10.1146\/annurev.pharmtox.39.1.267","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"2","key":"10082_CR108","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.yhbeh.2013.01.012","volume":"64","author":"ZA Klein","year":"2013","unstructured":"Klein, Z. A., & Romeo, R. D. (2013). Changes in hypothalamic\u2013pituitary\u2013adrenal stress responsiveness before and after puberty in rats. Hormones and Behavior, 64(2), 357\u2013363. https:\/\/doi.org\/10.1016\/j.yhbeh.2013.01.012","journal-title":"Hormones and Behavior"},{"key":"10082_CR109","doi-asserted-by":"publisher","unstructured":"Ding, Z., Liu, X., Jiang, H., Zhao, J., Temme, S., Bouvain, P., \u2026 & Ding, Z. (2024). A refined TTC assay precisely detects cardiac injury and cellular viability in the infarcted mouse heart. Scientific Reports, 14(1), 25214. https:\/\/doi.org\/10.1038\/s41598-024-76414-w","DOI":"10.1038\/s41598-024-76414-w"},{"issue":"1","key":"10082_CR110","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4103\/jfsm.jfsm_25_24","volume":"11","author":"MA Jebur","year":"2025","unstructured":"Jebur, M. A. (2025). Histochemical triphenyltetrazoium chloride staining versus ordinary hematoxylin and eosin staining in the detection of acute myocardial infarction in sudden death victims. Journal of Forensic Science and Medicine, 11(1), 58\u201361. https:\/\/doi.org\/10.4103\/jfsm.jfsm_25_24","journal-title":"Journal of Forensic Science and Medicine"},{"key":"10082_CR111","doi-asserted-by":"publisher","unstructured":"Masson, J.-D., Taglietti, V., Ruby, F., Ono, H., Mouri, N., Jorge, A., \u2026 & Relaix, F. (2025). Extensive striated muscle damage in a rat model of Duchenne muscular dystrophy with Dmd exons 10\u201317 duplication. Skeletal Muscle, 15(1), 16. https:\/\/doi.org\/10.1186\/s13395-025-00386-2","DOI":"10.1186\/s13395-025-00386-2"},{"issue":"2","key":"10082_CR112","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1161\/CIRCRESAHA.111.300496","volume":"112","author":"SF Steinberg","year":"2013","unstructured":"Steinberg, S. F. (2013). Oxidative stress and sarcomeric proteins. Circulation Research, 112(2), 393\u2013405. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.300496","journal-title":"Circulation Research"},{"key":"10082_CR113","doi-asserted-by":"publisher","unstructured":"Li, J., Liu, J., Yue, H., Ma, Y., Li, H., Hu, Y., \u2026 & Feng, Y. (2025). Elucidating the degradation mechanism of beef myofibrillar proteins under hydroxyl radical oxidation through the lens of cysteine oxidation modifications. Food Chemistry: X, 25, 102146. https:\/\/doi.org\/10.1016\/j.fochx.2024.102146","DOI":"10.1016\/j.fochx.2024.102146"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-10082-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-025-10082-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-025-10082-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:34:58Z","timestamp":1769222098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-025-10082-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":113,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10082"],"URL":"https:\/\/doi.org\/10.1007\/s12012-025-10082-8","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"17 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"6"}}