{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:03:46Z","timestamp":1784865826397,"version":"3.55.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s12012-026-10152-5","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:54:49Z","timestamp":1783738489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Mechanisms of Effects of Lead and Cadmium Co-exposure on Atrial and Ventricular Myocardium: Soluble Salts Versus Nanoparticles"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3853-1571","authenticated-orcid":false,"given":"Oksana","family":"Gerzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0647-0519","authenticated-orcid":false,"given":"Veronika","family":"Votinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-6775","authenticated-orcid":false,"given":"Salavat","family":"Nabiev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7362-2470","authenticated-orcid":false,"given":"Alyona","family":"Tzybina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0017-7573","authenticated-orcid":false,"given":"Natalia","family":"Stukalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6473-648X","authenticated-orcid":false,"given":"Maria","family":"Zhigulina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0927-4062","authenticated-orcid":false,"given":"Svetlana","family":"Klinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-7845","authenticated-orcid":false,"given":"Ilzira","family":"Minigalieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-7642","authenticated-orcid":false,"given":"Marina","family":"Sutunkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-2357","authenticated-orcid":false,"given":"Larisa","family":"Nikitina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"10152_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-7643-8340-4_6","volume":"101","author":"PB Tchounwou","year":"2012","unstructured":"Tchounwou, P. B., Yedjou, C. G., Patlolla, A. K., & Sutton, D. J. (2012). Heavy Metal Toxicity and the Environment. EXS, 101, 133\u2013164. https:\/\/doi.org\/10.1007\/978-3-7643-8340-4_6","journal-title":"EXS"},{"key":"10152_CR2","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/J.SCITOTENV.2018.06.068","volume":"642","author":"Q Yang","year":"2018","unstructured":"Yang, Q., Li, Z., Lu, X., Duan, Q., Huang, L., & Bi, J. (2018). A review of soil heavy metal pollution from industrial and agricultural regions in China: Pollution and risk assessment. Science of The Total Environment, 642, 690\u2013700. https:\/\/doi.org\/10.1016\/J.SCITOTENV.2018.06.068","journal-title":"Science of The Total Environment"},{"issue":"17","key":"10152_CR3","doi-asserted-by":"publisher","first-page":"17511","DOI":"10.1007\/S11356-016-6896-6","volume":"23:17","author":"TA Yekeen","year":"2016","unstructured":"Yekeen, T. A., Xu, X., Zhang, Y., Wu, Y., Kim, S., Reponen, T., & Huo, X. (2016). Assessment of health risk of trace metal pollution in surface soil and road dust from e-waste recycling area in China. Environmental Science and Pollution Research 2016, 23:17(17), 17511\u201317524. https:\/\/doi.org\/10.1007\/S11356-016-6896-6. 23.","journal-title":"Environmental Science and Pollution Research 2016"},{"key":"10152_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17072231","author":"C Ma","year":"2020","unstructured":"Ma, C., Iwai-Shimada, M., Tatsuta, N., Nakai, K., Isobe, T., Takagi, M., & Nakayama, S. F. (2020). Health risk assessment and source apportionment of mercury, lead, cadmium, selenium, and manganese in Japanese women: An adjunct study to the Japan environment and children\u2019s study. International Journal of Environmental Research and Public Health. https:\/\/doi.org\/10.3390\/ijerph17072231","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"10152_CR5","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ecoenv.2013.06.017","volume":"96","author":"J Zheng","year":"2013","unstructured":"Zheng, J., Chen, K., Yan, X., Chen, S. J., Hu, G. C., Peng, X. W., & Yang, Z. Y. (2013). Heavy metals in food, house dust, and water from an e-waste recycling area in South China and the potential risk to human health. Ecotoxicology and Environmental Safety, 96, 205\u2013212.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"10152_CR6","doi-asserted-by":"publisher","first-page":"135361","DOI":"10.1016\/J.JHAZMAT.2024.135361","volume":"478","author":"JA Howard","year":"2024","unstructured":"Howard, J. A., David, L., Lux, F., & Tillement, O. (2024). Low-level, chronic ingestion of lead and cadmium: The unspoken danger for at-risk populations. Journal of Hazardous Materials, 478, 135361. https:\/\/doi.org\/10.1016\/J.JHAZMAT.2024.135361","journal-title":"Journal of Hazardous Materials"},{"key":"10152_CR7","doi-asserted-by":"publisher","first-page":"128793","DOI":"10.1016\/j.chemosphere.2020.128793","volume":"268","author":"Z Chen","year":"2021","unstructured":"Chen, Z., Huo, X., Zhang, S., Cheng, Z., Huang, Y., & Xu, X. (2021). Relations of blood lead levels to echocardiographic left ventricular structure and function in preschool children. Chemosphere, 268, 128793. https:\/\/doi.org\/10.1016\/j.chemosphere.2020.128793","journal-title":"Chemosphere"},{"issue":"July","key":"10152_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fpubh.2023.1106732","volume":"11","author":"S Chen","year":"2023","unstructured":"Chen, S., Shen, R., Shen, J., Lyu, L., & Wei, T. (2023). Association of blood cadmium with all-cause and cause-specific mortality in patients with hypertension. Frontiers in Public Health, 11(July), 1\u201310. https:\/\/doi.org\/10.3389\/fpubh.2023.1106732","journal-title":"Frontiers in Public Health"},{"issue":"8","key":"10152_CR9","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.repce.2021.07.031","volume":"40","author":"HC Lin","year":"2021","unstructured":"Lin, H. C., Hao, W. M., & Chu, P. H. (2021). Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value. Revista Portuguesa de Cardiologia (English Edition), 40(8), 611\u2013617. https:\/\/doi.org\/10.1016\/j.repce.2021.07.031","journal-title":"Revista Portuguesa de Cardiologia (English Edition)"},{"issue":"23","key":"10152_CR10","doi-asserted-by":"publisher","first-page":"28833","DOI":"10.1007\/s11356-021-13725-9","volume":"28","author":"Z Chen","year":"2021","unstructured":"Chen, Z., Huo, X., Chen, G., Luo, X., & Xu, X. (2021). Lead (Pb) exposure and heart failure risk. Environmental Science and Pollution Research, 28(23), 28833\u201328847.","journal-title":"Environmental Science and Pollution Research"},{"issue":"7","key":"10152_CR11","doi-asserted-by":"publisher","first-page":"e68418","DOI":"10.1371\/JOURNAL.PONE.0068418","volume":"8","author":"CCP Almenara","year":"2013","unstructured":"Almenara, C. C. P., Broseghini-Filho, G. B., Vescovi, M. V. A., Angeli, J. K., Faria, T., de Stefanon, O., & Padilha, I., A. S (2013). Chronic Cadmium Treatment Promotes Oxidative Stress and Endothelial Damage in Isolated Rat Aorta. PLOS ONE, 8(7), e68418. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0068418","journal-title":"PLOS ONE"},{"issue":"5","key":"10152_CR12","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s10534-010-9314-4","volume":"23","author":"B Messner","year":"2010","unstructured":"Messner, B., & Bernhard, D. (2010). Cadmium and cardiovascular diseases: Cell biology, pathophysiology, and epidemiological relevance. BioMetals, 23(5), 811\u2013822. https:\/\/doi.org\/10.1007\/s10534-010-9314-4","journal-title":"BioMetals"},{"key":"10152_CR13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cotox.2020.01.004","volume":"19","author":"\u00c7 Sevim","year":"2020","unstructured":"Sevim, \u00c7., Do\u011fan, E., & Comakli, S. (2020). Cardiovascular disease and toxic metals. Current Opinion in Toxicology, 19, 88\u201392. https:\/\/doi.org\/10.1016\/j.cotox.2020.01.004","journal-title":"Current Opinion in Toxicology"},{"issue":"2","key":"10152_CR14","doi-asserted-by":"publisher","first-page":"H454","DOI":"10.1152\/ajpheart.00158.2008","volume":"295","author":"ND Vaziri","year":"2008","unstructured":"Vaziri, N. D. (2008). Mechanisms of lead-induced hypertension and cardiovascular disease. Physiology American Journal of Physiology-Heart and Circulatory, 295(2), H454\u2013H465.","journal-title":"Physiology American Journal of Physiology-Heart and Circulatory"},{"issue":"2","key":"10152_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0017117","volume":"6","author":"J Fiorim","year":"2011","unstructured":"Fiorim, J., J\u00fanior, R. F., Silveira, E. A., Padilha, A. S., Vescovi, M. V., de Jesus, H. C., & Vassallo, D. V. (2011). Low-Level Lead Exposure Increases Systolic Arterial Pressure and Endothelium-Derived Vasodilator Factors in Rat Aortas. Plos One, 6(2), 1\u20139.","journal-title":"Plos One"},{"issue":"4","key":"10152_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3346\/jkms.2016.31.4.489","volume":"31","author":"YD Kim","year":"2016","unstructured":"Kim, Y. D., Eom, S. Y., Yim, D. H., Kim, I. S., Won, H. K., Park, C. H., & Kim, H. (2016). Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea. Journal of Korean Medical Science, 31(4), 489. https:\/\/doi.org\/10.3346\/jkms.2016.31.4.489","journal-title":"Journal of Korean Medical Science"},{"key":"10152_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018730","author":"MR Sim\u00f5es","year":"2011","unstructured":"Sim\u00f5es, M. R., Ribeiro, R. F., Vescovi, M. V. A., de Jesus, H. C., Padilha, A. S., Stefanon, I., & Fioresi, M. (2011). Acute lead exposure increases arterial pressure: Role of the renin-angiotensin system. Plos One. https:\/\/doi.org\/10.1371\/journal.pone.0018730","journal-title":"Plos One"},{"issue":"1","key":"10152_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1152\/ajpheart.1980.239.1.h22","volume":"8","author":"SJ Kopp","year":"1980","unstructured":"Kopp, S. J., Perry, H. M., & Glonek, T. (1980). Cardiac physiologic-metabolic changes after chronic low-level heavy metal feeding. American Journal of Physiology - Heart and Circulatory Physiology, 8(1), 22\u201330. https:\/\/doi.org\/10.1152\/ajpheart.1980.239.1.h22","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"key":"10152_CR19","doi-asserted-by":"publisher","first-page":"111641","DOI":"10.1016\/j.fct.2020.111641","volume":"144","author":"BA Katsnelson","year":"2020","unstructured":"Katsnelson, B. A., Klinova, S. V., Gerzen, O. P., Balakin, A. A., Lookin, O. N., Lisin, R. V., & Protsenko, Y. L. (2020). Force-velocity characteristics of isolated myocardium preparations from rats exposed to subchronic intoxication with lead and cadmium acting separately or in combination. Food and Chemical Toxicology, 144, 111641. https:\/\/doi.org\/10.1016\/j.fct.2020.111641","journal-title":"Food and Chemical Toxicology"},{"key":"10152_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.toxrep.2020.03.001","volume":"7","author":"YL Protsenko","year":"2020","unstructured":"Protsenko, Y. L., Klinova, S. V., Gerzen, O. P., Privalova, L. I., Minigalieva, I. A., Balakin, A. A., & Katsnelson, B. A. (2020). Changes in rat myocardium contractility under subchronic intoxication with lead and cadmium salts administered alone or in combination. Toxicology Reports, 7, 433\u2013442. https:\/\/doi.org\/10.1016\/j.toxrep.2020.03.001","journal-title":"Toxicology Reports"},{"key":"10152_CR21","doi-asserted-by":"publisher","first-page":"101048","DOI":"10.1016\/j.mam.2021.101048","volume":"87","author":"G Ferreira","year":"2022","unstructured":"Ferreira, G., Santander, A., Chavarr\u00eda, L., Cardozo, R., Savio, F., Sobrevia, L., & Nicolson, G. L. (2022). Functional consequences of lead and mercury exposomes in the heart. Molecular Aspects of Medicine, 87, 101048. https:\/\/doi.org\/10.1016\/j.mam.2021.101048","journal-title":"Molecular Aspects of Medicine"},{"issue":"9","key":"10152_CR22","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1111\/jcmm.13702","volume":"22","author":"J Shen","year":"2018","unstructured":"Shen, J., Wang, X., Zhou, D., Li, T., Tang, L., Gong, T., & Liang, P. (2018). Modelling cadmium-induced cardiotoxicity using human pluripotent stem cell-derived cardiomyocytes. Journal of Cellular and Molecular Medicine, 22(9), 4221\u20134235. https:\/\/doi.org\/10.1111\/jcmm.13702","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"10","key":"10152_CR23","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1002\/etc.5161","volume":"40","author":"J Haverinen","year":"2021","unstructured":"Haverinen, J., Badr, A., & Vornanen, M. (2021). Cardiac Toxicity of Cadmium Involves Complex Interactions Among Multiple Ion Currents in Rainbow Trout (Oncorhynchus mykiss) Ventricular Myocytes. Environmental Toxicology and Chemistry, 40(10), 2874\u20132885. https:\/\/doi.org\/10.1002\/etc.5161","journal-title":"Environmental Toxicology and Chemistry"},{"issue":"23","key":"10152_CR24","doi-asserted-by":"publisher","first-page":"29266","DOI":"10.1007\/s11356-020-09011-9","volume":"27","author":"S Ali","year":"2020","unstructured":"Ali, S., Awan, Z., Mumtaz, S., Shakir, H. A., Ahmad, F., Ulhaq, M., & Khan, M. A. (2020). Cardiac toxicity of heavy metals (cadmium and mercury) and pharmacological intervention by vitamin C in rabbits. Environmental Science and Pollution Research, 27(23), 29266\u201329279. https:\/\/doi.org\/10.1007\/s11356-020-09011-9","journal-title":"Environmental Science and Pollution Research"},{"issue":"5","key":"10152_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.5937\/mp74-46164","volume":"74","author":"A \u0106irovi\u0107","year":"2023","unstructured":"\u0106irovi\u0107, A., & Tasi\u0107, N. (2023). Accumulation of metal (loid) s in myocardial tissue and the mechanisms underlying their cardiotoxic effects. Medicinski podmladak, 74(5), 21\u201325.","journal-title":"Medicinski podmladak"},{"issue":"1\u20133","key":"10152_CR26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10661-005-0298-4","volume":"101","author":"W Ashraf","year":"2005","unstructured":"Ashraf, W. (2005). Accumulation of heavy metals in kidney and heart tissues of Epinephelus Micrdon fish from the Arabian Gulf. Environmental Monitoring and Assessment, 101(1\u20133), 311\u2013316. https:\/\/doi.org\/10.1007\/s10661-005-0298-4","journal-title":"Environmental Monitoring and Assessment"},{"issue":"1","key":"10152_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0006-3061(00)81014-5","volume":"3","author":"J Webb","year":"1973","unstructured":"Webb, J., Kirk, K. A., Niedermeier, W., Griggs, J. H., Turner, M. E., & James, T. N. (1973). Distribution of 13 trace metals in pig heart tissue. Bioinorganic Chemistry, 3(1), 61\u201375. https:\/\/doi.org\/10.1016\/S0006-3061(00)81014-5","journal-title":"Bioinorganic Chemistry"},{"key":"10152_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/biom13081232","author":"A Cirovic","year":"2023","unstructured":"Cirovic, A., Orisakwe, O. E., Cirovic, A., Jevtic, J., Tasic, D., & Tasic, N. (2023). Non-uniform bioaccumulation of lead and arsenic in two remote regions of the human heart\u2019s left ventricle: A post-mortem study. Biomolecules. https:\/\/doi.org\/10.3390\/biom13081232","journal-title":"Biomolecules"},{"issue":"7","key":"10152_CR29","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1134\/S0006297924070095","volume":"89","author":"OP Gerzen","year":"2024","unstructured":"Gerzen, O. P., Potoskueva, I. K., Tzybina, A. E., Myachina, T. A., & Nikitina, L. V. (2024). Cardiac Myosin and Thin Filament as Targets for Lead and Cadmium Divalent Cations. Biochemistry (Moscow), 89(7), 1273\u20131282. https:\/\/doi.org\/10.1134\/S0006297924070095","journal-title":"Biochemistry (Moscow)"},{"issue":"July","key":"10152_CR30","doi-asserted-by":"publisher","first-page":"115673","DOI":"10.1016\/j.fct.2025.115673","volume":"204","author":"O Gerzen","year":"2025","unstructured":"Gerzen, O., Tzybina, A., Nabiev, S., Potoskueva, I., Stukalova, N., Votinova, V., & Nikitina, L. (2025). Molecular basis of cadmium Cardiotoxicity: Chamber-Specific effects of CdO nanoparticles and soluble CdCl2 exposure. Food and Chemical Toxicology, 204(July), 115673. https:\/\/doi.org\/10.1016\/j.fct.2025.115673","journal-title":"Food and Chemical Toxicology"},{"issue":"September","key":"10152_CR31","doi-asserted-by":"publisher","first-page":"113444","DOI":"10.1016\/j.fct.2022.113444","volume":"169","author":"OP Gerzen","year":"2022","unstructured":"Gerzen, O. P., Nabiev, S. R., Klinova, S. V., Minigalieva, I. A., Sutunkova, M. P., Katsnelson, B. A., & Nikitina, L. V. (2022). Molecular mechanisms of mechanical function changes of the rat myocardium under subchronic lead exposure. Food and Chemical Toxicology, 169(September), 113444. https:\/\/doi.org\/10.1016\/j.fct.2022.113444","journal-title":"Food and Chemical Toxicology"},{"issue":"July","key":"10152_CR32","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.toxlet.2025.07.1413","volume":"411","author":"O Gerzen","year":"2025","unstructured":"Gerzen, O., Nabiev, S., Tzybina, A., Potoskueva, I., Votinova, V., Klinova, S., & Nikitina, L. (2025). Nano-assault on the heart: Molecular pathways of lead oxide nanoparticle cardiotoxicity. Toxicology Letters, 411(July), 80\u201388. https:\/\/doi.org\/10.1016\/j.toxlet.2025.07.1413","journal-title":"Toxicology Letters"},{"issue":"1","key":"10152_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40557-017-0202-z","volume":"29","author":"HC An","year":"2017","unstructured":"An, H. C., Sung, J. H., Lee, J., Sim, C. S., Kim, S. H., & Kim, Y. (2017). The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: A cross-sectional study. Annals of Occupational and Environmental Medicine, 29(1), 1\u20138. https:\/\/doi.org\/10.1186\/s40557-017-0202-z","journal-title":"Annals of Occupational and Environmental Medicine"},{"key":"10152_CR34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1136\/bmj.k3310","volume":"362","author":"R Chowdhury","year":"2018","unstructured":"Chowdhury, R., Ramond, A., O\u2019Keeffe, L. M., Shahzad, S., Kunutsor, S. K., Muka, T., & Di Angelantonio, E. (2018). Environmental toxic metal contaminants and risk of cardiovascular disease: Systematic review and meta-analysis. BMJ (Online), 362, 14\u201316. https:\/\/doi.org\/10.1136\/bmj.k3310","journal-title":"BMJ (Online)"},{"key":"10152_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16020274","author":"M Andjelkovic","year":"2019","unstructured":"Andjelkovic, M., Djordjevic, A. B., Antonijevic, E., Antonijevic, B., Stanic, M., Kotur-Stevuljevic, J., & Bulat, Z. (2019). Toxic effect of acute cadmium and lead exposure in rat blood, liver, and kidney. International Journal of Environmental Research and Public Health. https:\/\/doi.org\/10.3390\/ijerph16020274","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"1","key":"10152_CR36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1515\/aiht-2015-66-2515","volume":"66","author":"I Markiewicz-G\u00f3rka","year":"2015","unstructured":"Markiewicz-G\u00f3rka, I., Januszewska, L., Michalak, A., Prokopowicz, A., Januszewska, E., Pawlas, N., & Pawlas, K. (2015). Effects of chronic exposure to lead, cadmium, and manganese mixtures on oxidative stress in rat liver and heart. Arhiv za higijenu rada i toksikologiju, 66(1), 51\u201362. https:\/\/doi.org\/10.1515\/aiht-2015-66-2515","journal-title":"Arhiv za higijenu rada i toksikologiju"},{"issue":"7","key":"10152_CR37","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1080\/09603123.2023.2265310","volume":"34","author":"H Medjedded","year":"2024","unstructured":"Medjedded, H., Nemiche, S., & Nemmiche, S. (2024). Individual and combined effects of cadmium and lead exposure in rats. International Journal of Environmental Health Research, 34(7), 2649\u20132660. https:\/\/doi.org\/10.1080\/09603123.2023.2265310","journal-title":"International Journal of Environmental Health Research"},{"issue":"4","key":"10152_CR38","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1007\/s10653-021-00857-7","volume":"43","author":"M Burachevskaya","year":"2021","unstructured":"Burachevskaya, M., Minkina, T., Mandzhieva, S., Bauer, T., Nevidomskaya, D., Shuvaeva, V., & Rajput, V. (2021). Transformation of copper oxide and copper oxide nanoparticles in the soil and their accumulation by Hordeum sativum. Environmental Geochemistry and Health, 43(4), 1655\u20131672. https:\/\/doi.org\/10.1007\/s10653-021-00857-7","journal-title":"Environmental Geochemistry and Health"},{"issue":"1","key":"10152_CR39","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1021\/nl0347334","volume":"4","author":"A Derfus","year":"2004","unstructured":"Derfus, A., Chan, W. C., & Bhatia, S. N. (2004). Probing the cytotoxicity of semiconductor quantum dots. Nano Letters, 4(1), 11\u201318.","journal-title":"Nano Letters"},{"issue":"4","key":"10152_CR40","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1152\/ajpheart.00274.2002","volume":"283","author":"NR Alpert","year":"2002","unstructured":"Alpert, N. R., Brosseau, C., Federico, A., Krenz, M., Robbins, J., & Warshaw, D. M. (2002). Molecular mechanics of mouse cardiac myosin isoforms. American Journal of Physiology - Heart and Circulatory Physiology, 283(4), 1446\u20131454. https:\/\/doi.org\/10.1152\/ajpheart.00274.2002. 52\u2009\u2013\u20094.","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"issue":"11","key":"10152_CR41","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/0022-2828(78)90401-7","volume":"10","author":"JF Hoh","year":"1978","unstructured":"Hoh, J. F., & McGrath, P. A. (1978). Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement. Journal of Molecular and Cellular Cardiology, 10(11), 1053\u20131060.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"47","key":"10152_CR42","doi-asserted-by":"publisher","first-page":"15058","DOI":"10.1021\/bi0495329","volume":"43","author":"UP Malmqvist","year":"2004","unstructured":"Malmqvist, U. P., Aronshtam, A., & Lowey, S. (2004). Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties. Biochemistry, 43(47), 15058\u201315065. https:\/\/doi.org\/10.1021\/bi0495329","journal-title":"Biochemistry"},{"issue":"3","key":"10152_CR43","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cardiores.2003.09.011","volume":"60","author":"H Yamashita","year":"2003","unstructured":"Yamashita, H., Sugiura, S., Fujita, H., Yasuda, S. I., Nagai, R., Saeki, Y., & Sugi, H. (2003). Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction. Cardiovascular Research, 60(3), 580\u2013588. https:\/\/doi.org\/10.1016\/j.cardiores.2003.09.011","journal-title":"Cardiovascular Research"},{"key":"10152_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073466","author":"SV Klinova","year":"2021","unstructured":"Klinova, S. V., Katsnelson, B. A., Minigalieva, I. A., Gerzen, O. P., Balakin, A. A., Lisin, R. V., & Protsenko, Y. L. (2021). Cardioinotropic effects in subchronic intoxication of rats with lead and\/or cadmium oxide nanoparticles. International Journal of Molecular Sciences. https:\/\/doi.org\/10.3390\/ijms22073466","journal-title":"International Journal of Molecular Sciences"},{"issue":"8","key":"10152_CR45","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.47470\/0016-9900-2023-102-11-1228-1235","volume":"102","author":"SV Klinova","year":"2023","unstructured":"Klinova, S. V., Ilzira, A., Minigalieva, Sutunkova, M. P., & Shabardina, L. V. (2023). Integral indicators of cardiotoxicity of lead and cadmium on the background of physical activity. Hygiene & Sanitation, 102(8), 1228\u20131235.","journal-title":"Hygiene & Sanitation"},{"issue":"2","key":"10152_CR46","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1080\/17435390.2020.1845410","volume":"15","author":"MP Sutunkova","year":"2021","unstructured":"Sutunkova, M. P., Minigalieva, I. A., Klinova, S. V., Panov, V. G., Gurvich, V. B., Privalova, L. I., & Katsnelson, B. A. (2021). Some data on the comparative and combined toxic activity of nanoparticles containing lead and cadmium with special attention to their vasotoxicity. Nanotoxicology, 15(2), 205\u2013222. https:\/\/doi.org\/10.1080\/17435390.2020.1845410","journal-title":"Nanotoxicology"},{"key":"10152_CR47","doi-asserted-by":"publisher","unstructured":"Huang, Z. (2022). Association Between Blood Lead Level With High Blood Pressure in US, 10(April). https:\/\/doi.org\/10.3389\/fpubh.2022.836357","DOI":"10.3389\/fpubh.2022.836357"},{"issue":"C","key":"10152_CR48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0076-6879(82)85009-X","volume":"85","author":"SS Margossian","year":"1982","unstructured":"Margossian, S. S., & Lowey, S. (1982). Preparation of Myosin and Its Subfragments from Rabbit Skeletal Muscle. Methods in Enzymology, 85(C), 55\u201371. https:\/\/doi.org\/10.1016\/0076-6879(82)85009-X","journal-title":"Methods in Enzymology"},{"issue":"2","key":"10152_CR49","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1006\/jsbi.1999.4111","volume":"126","author":"M Spiess","year":"1999","unstructured":"Spiess, M., Steinmetz, M. O., Mandinova, A., Wolpensinger, B., Aebi, U., & Atar, D. (1999). Isolation, electron microscopic imaging, and 3-D visualization of native cardiac thin myofilaments. Journal of Structural Biology, 126(2), 98\u2013104. https:\/\/doi.org\/10.1006\/jsbi.1999.4111","journal-title":"Journal of Structural Biology"},{"key":"10152_CR50","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0091-679X(08)60661-5","volume":"24","author":"JD Pardee","year":"1982","unstructured":"Pardee, J. D., & Spudich, J. A. (1982). Purification of muscle actin. InMethods in cell biology. Methods in Cell Biology, 24, 271\u2013289.","journal-title":"Methods in Cell Biology"},{"key":"10152_CR51","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0076-6879(82)85024-6","volume":"85","author":"JD Potter","year":"1982","unstructured":"Potter, J. D. (1982). Preparation of troponin and its subnits. Methods in Enzymology, 85, 241\u2013263.","journal-title":"Methods in Enzymology"},{"issue":"8","key":"10152_CR52","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1111\/febs.12756","volume":"281","author":"AM Matyushenko","year":"2014","unstructured":"Matyushenko, A. M., Artemova, N. V., Shchepkin, D. V., Kopylova, G. V., Bershitsky, S. Y., Tsaturyan, A. K., & Levitsky, D. I. (2014). Structural and functional effects of two stabilizing substitutions, D137L and G126R, in the middle part of \u03b1-tropomyosin molecule. FEBS Journal, 281(8), 2004\u20132016. https:\/\/doi.org\/10.1111\/febs.12756","journal-title":"FEBS Journal"},{"issue":"3","key":"10152_CR53","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S0006-3495(97)78776-9","volume":"72","author":"AM Gordon","year":"1997","unstructured":"Gordon, A. M., LaMadrid, M. A., Chen, Y., Luo, Z., & Chase, P. B. (1997). Calcium regulation of skeletal muscle thin filament motility in vitro. Biophysical Journal, 72(3), 1295\u20131307. https:\/\/doi.org\/10.1016\/S0006-3495(97)78776-9","journal-title":"Biophysical Journal"},{"key":"10152_CR54","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1134\/S0022093022070109","volume":"58","author":"OP Gerzen","year":"2022","unstructured":"Gerzen, O. P., Potoskueva, I. K., Permyakova, Y. V., Grebenschchikova, A. V., Selezneva, I. S., & Nikitina, L. V. (2022). SDS-PAGE for Myosin Heavy Chains: Fast and Furious. Journal of Evolutionary Biochemistry and Physiology, 58, 92\u201397. https:\/\/doi.org\/10.1134\/S0022093022070109","journal-title":"Journal of Evolutionary Biochemistry and Physiology"},{"issue":"5259","key":"10152_CR55","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227(5259), 680\u2013685.","journal-title":"Nature"},{"issue":"2","key":"10152_CR56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s10541-008-2009-6","volume":"73","author":"LV Nikitina","year":"2008","unstructured":"Nikitina, L. V., Kopylova, G. V., Shchepkin, D. V., & Katsnelson, L. B. (2008). Study of the interaction between rabbit cardiac contractile and regulatory proteins. An in vitro motility assay. Biochemistry (Moscow), 73(2), 178\u2013184. https:\/\/doi.org\/10.1007\/s10541-008-2009-6","journal-title":"Biochemistry (Moscow)"},{"issue":"6","key":"10152_CR57","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1529\/biophysj.106.081117","volume":"92","author":"GI Mashanov","year":"2007","unstructured":"Mashanov, G. I., & Molloy, J. E. (2007). Automatic detection of single fluorophores in live cells. Biophysical Journal, 92(6), 2199\u20132211. https:\/\/doi.org\/10.1529\/biophysj.106.081117","journal-title":"Biophysical Journal"},{"issue":"4 SUPPL","key":"10152_CR58","first-page":"306","volume":"68","author":"JR Haeberle","year":"1995","unstructured":"Haeberle, J. R., Hemric, M. E., Chacko, S., Pollack, J., & Reggiani, C. (1995). Are actin filaments moving under unloaded conditions in the in vitro motility assay? Biophysical Journal, 68(4 SUPPL.), 306\u2013310.","journal-title":"Biophysical Journal"},{"key":"10152_CR59","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1042\/bj3500693","volume":"350","author":"W Bing","year":"2000","unstructured":"Bing, W., Knott, A., & Marston, S. B. (2000). A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: Evidence that tropomyosin and troponin increase force in single thin filaments. The Biochemical Journal, 350, 693\u2013699.","journal-title":"The Biochemical Journal"},{"issue":"6","key":"10152_CR60","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00424-011-1024-4","volume":"462","author":"RJ Belin","year":"2011","unstructured":"Belin, R. J., Sumandea, M. P., Sievert, G. A., Harvey, L. A., Geenen, D. L., Solaro, R. J., & de Tombe, P. P. (2011). Interventricular differences in myofilament function in experimental congestive heart failure. Pfl\u00fcgers Archiv - European Journal of Physiology, 462(6), 795\u2013809. https:\/\/doi.org\/10.1007\/s00424-011-1024-4","journal-title":"Pfl\u00fcgers Archiv - European Journal of Physiology"},{"issue":"3\u20134","key":"10152_CR61","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.vph.2009.10.001","volume":"52","author":"N Tribulova","year":"2010","unstructured":"Tribulova, N., Knezl, V., Shainberg, A., Seki, S., & Soukup, T. (2010). Thyroid hormones and cardiac arrhythmias. Vascular Pharmacology, 52(3\u20134), 102\u2013112. https:\/\/doi.org\/10.1016\/j.vph.2009.10.001","journal-title":"Vascular Pharmacology"},{"issue":"7","key":"10152_CR62","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1089\/thy.2008.0043","volume":"18","author":"S Danzi","year":"2008","unstructured":"Danzi, S., Klein, S., & Klein, I. (2008). Differential regulation of the myosin heavy chain genes \u03b1 and \u03b2 in rat atria and ventricles: Role of antisense RNA. Thyroid : Official Journal Of The American Thyroid Association, 18(7), 761\u2013768. https:\/\/doi.org\/10.1089\/thy.2008.0043","journal-title":"Thyroid : Official Journal Of The American Thyroid Association"},{"key":"10152_CR78","doi-asserted-by":"publisher","unstructured":"Bernal-Ramirez, J., Diaz-Vesga, M. C., Talamilla, M., Mendez, A., Quiroga, C., Garza-Cervantes, J. A., \u2026 Pedrozo, Z. (2021). Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction. Oxidative Medicine and Cellular Longevity, 2021 https:\/\/doi.org\/10.1155\/2021\/9993060","DOI":"10.1155\/2021\/9993060"},{"key":"10152_CR79","doi-asserted-by":"publisher","unstructured":"Chen, A., Kim, S. S., Chung, E., & Dietrich, K. N. (2013). Thyroid hormones in relation to lead, mercury, and cadmium exposure in the national health and nutrition examination survey, 2007-2008. Environmental Health Perspectives, 121(2), 181\u2013186 https:\/\/doi.org\/10.1289\/ehp.1205239","DOI":"10.1289\/ehp.1205239"},{"key":"10152_CR80","doi-asserted-by":"publisher","unstructured":"Hammouda, F., Messaoudi, I., El Hani, J., Baati, T., Sa\u00efd, K., & Kerkeni, A. (2008). Reversal of cadmium-induced thyroid dysfunction by selenium, zinc, or their combination in rat. Biological Trace Element Research, 126(1\u20133), 194\u2013203. https:\/\/doi.org\/10.1007\/s12011-008-8194-8","DOI":"10.1007\/s12011-008-8194-8"},{"key":"10152_CR81","doi-asserted-by":"publisher","unstructured":"Campbell, S.E. & Gerdes, A.M., (1988). Regional changes in myocyte size during the reversal of thyroid-inducedcardiac hypertrophy. Journal of molecular and cellular cardiology, 20(5), 379-387. https:\/\/doi.org\/10.1016\/S0022-2828(88)80129-9","DOI":"10.1016\/S0022-2828(88)80129-9"},{"key":"10152_CR67","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-025-10043-1","author":"YL Protsenko","year":"2025","unstructured":"Protsenko, Y. L., Balakin, A., Minigalieva, I. A., Kuznetsov, D. A., Votinova, V., Lisin, R., & Gerzen, O. (2025). Dose-Dependent Effects of Subchronic Lead Exposure on the Right Atrium and Right Ventricle of Rats: An In Vitro Investigation. Cardiovascular Toxicology. https:\/\/doi.org\/10.1007\/s12012-025-10043-1","journal-title":"Cardiovascular Toxicology"},{"issue":"1","key":"10152_CR68","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00249-017-1209-7","volume":"47","author":"G Kopylova","year":"2018","unstructured":"Kopylova, G., Nabiev, S., Shchepkin, D., & Bershitsky, S. (2018). Carbonylation of atrial myosin prolongs its interaction with actin. European Biophysics Journal, 47(1), 11\u201318. https:\/\/doi.org\/10.1007\/s00249-017-1209-7","journal-title":"European Biophysics Journal"},{"key":"10152_CR69","doi-asserted-by":"publisher","unstructured":"Almeida Lopes, A. C. B., Peixe, T. S., Mesas, A. E., & Paoliello, M. M. B. (2016). Lead exposure and oxidative stress: A systematic review. In Reviews of Environmental Contamination and Toxicology (Vol. 236, pp. 193\u2013238). Springer New York LLC. https:\/\/doi.org\/10.1007\/978-3-319-20013-2_3","DOI":"10.1007\/978-3-319-20013-2_3"},{"key":"10152_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.112825","author":"D Javorac","year":"2022","unstructured":"Javorac, D., Tatovi\u0107, S., An\u0111elkovi\u0107, M., Repi\u0107, A., Barali\u0107, K., Djordjevic, A. B., & Bulat, Z. (2022). Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling. Food and Chemical Toxicology. https:\/\/doi.org\/10.1016\/j.fct.2022.112825","journal-title":"Food and Chemical Toxicology"},{"issue":"1","key":"10152_CR71","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/J.FREERADBIOMED.2007.09.004","volume":"44","author":"JH Snook","year":"2008","unstructured":"Snook, J. H., Li, J., Helmke, B. P., & Guilford, W. H. (2008). Peroxynitrite inhibits myofibrillar protein function in an in vitro assay of motility. Free Radical Biology and Medicine, 44(1), 14\u201323. https:\/\/doi.org\/10.1016\/J.FREERADBIOMED.2007.09.004","journal-title":"Free Radical Biology and Medicine"},{"issue":"4","key":"10152_CR72","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1134\/s002209302104013x","volume":"57","author":"OP Gerzen","year":"2021","unstructured":"Gerzen, O. P., Nabiev, S. R., & Nikitina, L. V. (2021). Influence of Chronic Lead Intoxication on Functional Characteristics and Isoform Composition of Left Ventricular Myosin in the Rat Heart. Journal of Evolutionary Biochemistry and Physiology, 57(4), 896\u2013903. https:\/\/doi.org\/10.1134\/s002209302104013x","journal-title":"Journal of Evolutionary Biochemistry and Physiology"},{"issue":"8","key":"10152_CR73","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1021\/acs.chemrestox.8b00397","volume":"32","author":"KC Nguyen","year":"2019","unstructured":"Nguyen, K. C., Zhang, Y., Todd, J., Kittle, K., Patry, D., Caldwell, D., & Tayabali, A. F. (2019). Biodistribution and Systemic Effects in Mice Following Intravenous Administration of Cadmium Telluride Quantum Dot Nanoparticles. Chemical Research in Toxicology, 32(8), 1491\u20131503. https:\/\/doi.org\/10.1021\/acs.chemrestox.8b00397","journal-title":"Chemical Research in Toxicology"},{"issue":"3","key":"10152_CR74","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3109\/21691401.2015.1008507","volume":"44","author":"K Kalishwaralal","year":"2016","unstructured":"Kalishwaralal, K., Jeyabharathi, S., Sundar, K., & Muthukumaran, A. (2016). Comparative analysis of cardiovascular effects of selenium nanoparticles and sodium selenite in zebrafish embryos. Artificial Cells Nanomedicine and Biotechnology, 44(3), 990\u2013996. https:\/\/doi.org\/10.3109\/21691401.2015.1008507","journal-title":"Artificial Cells Nanomedicine and Biotechnology"},{"key":"10152_CR75","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/20\/21\/215101","author":"CH Lin","year":"2009","unstructured":"Lin, C. H., Chang, L. W., Chang, H., Yang, M. H., Yang, C. S., Lai, W. H., & Lin, P. (2009). The chemical fate of the Cd\/Se\/Te-based quantum dot 705 in the biological system: Toxicity implications. Nanotechnology. https:\/\/doi.org\/10.1088\/0957-4484\/20\/21\/215101","journal-title":"Nanotechnology"},{"issue":"2","key":"10152_CR76","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1039\/C8EN00893K","volume":"6","author":"DQ Ng","year":"2019","unstructured":"Ng, D. Q., Chu, Y., Tan, S. W., Wang, S. L., Lin, Y. P., Chu, C. H., & Chen, P. J. (2019). In vivo evidence of intestinal lead dissolution from lead dioxide (PbO2) nanoparticles and resulting bioaccumulation and toxicity in medaka fish. Environmental Science Nano, 6(2), 580\u2013591. https:\/\/doi.org\/10.1039\/C8EN00893K","journal-title":"Environmental Science Nano"},{"issue":"1","key":"10152_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12989-017-0236-y","volume":"14","author":"J Dumkov\u00e1","year":"2017","unstructured":"Dumkov\u00e1, J., Smutn\u00e1, T., Vrl\u00edkov\u00e1, L., Le Coustumer, P., Ve\u010de\u0159a, Z., Do\u010dekal, B., & Buchtov\u00e1, M. (2017). Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs. Particle and Fibre Toxicology, 14(1), 1\u201319. https:\/\/doi.org\/10.1186\/s12989-017-0236-y","journal-title":"Particle and Fibre Toxicology"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-026-10152-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T03:54:49Z","timestamp":1784865289000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-026-10152-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10152"],"URL":"https:\/\/doi.org\/10.1007\/s12012-026-10152-5","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"20 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Yekaterinburg Medical Research Centre for Prevention and Health Protection of Industrial Workers (protocol No. 2, dated 18 January 2018). All procedures were conducted in accordance with the European Parliament Directive 2010\/63\/EU and the US National Institutes of Health\u2019s \u201cGuide for the Care and Use of Laboratory Animals\u201d (NIH Publication No. 85\u2009\u2212\u200923, revised 1996). All animal experiments complied with the ARRIVE (Animal Research: Reporting of in vivo Experiments) guidelines.","order":2,"name":"Ethics","label":"Institutional Review Board Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed Consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"(1) Significant differences exist in cardiac mechanical and electrophysiological processes between small rodents and large mammals; therefore, extrapolating these findings to humans requires caution. (2) Since this study analyzed proteins isolated from atrial and ventricular tissues, the molecular-level changes observed may not fully represent functional alterations at the organ or systemic level. Consequently, the results should be interpreted within this context. (3) Humans are typically exposed to lead and cadmium through environmental sources (air, food, water), where intake is variable and difficult to quantify. Our model used precise intraperitoneal injections\u2014a non-physiological route that ensures controlled dosing for experimental validation. Therefore, comparisons with human exposure must be made cautiously due to the different routes of administration. (4) Using Pro-Q Diamond for quantitation of phosphorylation is appropriate for highlighting trends or evaluating large differences; therefore, statistically significant but small differences should be interpreted with caution.","order":4,"name":"Ethics","label":"Study Limitations","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"78"}}