{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:33:08Z","timestamp":1787592788545,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200304"],"award-info":[{"award-number":["82200304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s12012-026-10166-z","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:14:23Z","timestamp":1784895263000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lapatinib Induces Ferroptosis in Cardiomyocytes by Regulating ATF4\/GPX4"],"prefix":"10.1007","volume":"26","author":[{"given":"Yue","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-0088","authenticated-orcid":false,"given":"Yilan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"10166_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fcvm.2018.00009","volume":"5","author":"J Dong","year":"2018","unstructured":"Dong, J., & Chen, H. (2018). Cardiotoxicity of anticancer therapeutics. Frontiers in Cardiovascular Medicine, 5, 9.","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10166_CR2","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3389\/fcell.2020.00434","volume":"8","author":"W Ma","year":"2020","unstructured":"Ma, W., Wei, S., Zhang, B., & Li, W. (2020). Molecular mechanisms of cardiomyocyte death in drug-induced cardiotoxicity. Frontiers in Cell and Developmental Biology, 8, 434.","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10166_CR3","doi-asserted-by":"publisher","DOI":"10.1177\/15330338211037812","volume":"20","author":"X Wang","year":"2021","unstructured":"Wang, X., Wang, L., Yu, Q., Liu, Z., Li, C., Wang, F., & Yu, Z. (2021). The effectiveness of lapatinib in HER2-positive metastatic breast cancer patients pretreated with multiline anti-HER2 treatment: A retrospective study in China. Technology in Cancer Research & Treatment, 20, Article 15330338211037812.","journal-title":"Technology in Cancer Research & Treatment"},{"key":"10166_CR4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1158\/1535-7163.MCT-15-0887","volume":"16","author":"MF Press","year":"2017","unstructured":"Press, M. F., Ellis, C. E., Gagnon, R. C., Grob, T. J., Buyse, M., Villalobos, I., Liang, Z., Wu, S., Bang, Y. J., Qin, S. K., Chung, H. C., Xu, J., Park, J. O., Jeziorski, K., Afenjar, K., Ma, Y., Estrada, M. C., Robinson, D. M., Scherer, S. J., Sauter, G., Hecht, J. R., & Slamon, D. J. (2017). HER2 Status in Advanced or Metastatic Gastric, Esophageal, or Gastroesophageal Adenocarcinoma for Entry to the TRIO-013\/LOGiC Trial of Lapatinib. Molecular Cancer Therapeutics, 16, 228\u2013238.","journal-title":"Molecular Cancer Therapeutics"},{"key":"10166_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-3-319-91442-8_2","volume":"211","author":"M Voigtlaender","year":"2018","unstructured":"Voigtlaender, M., Schneider-Merck, T., & Trepel, M. (2018). Lapatinib. Recent Results Cancer Research, 211, 19\u201344.","journal-title":"Recent Results Cancer Research"},{"key":"10166_CR6","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1002\/ijc.25896","volume":"129","author":"K Mimura","year":"2011","unstructured":"Mimura, K., Kono, K., Maruyama, T., Watanabe, M., Izawa, S., Shiba, S., Mizukami, Y., Kawaguchi, Y., Inoue, M., Kono, T., Choudhury, A., Kiessling, R., & Fujii, H. (2011). Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell lines. International Journal of Cancer, 129, 2408\u20132416.","journal-title":"International Journal of Cancer"},{"key":"10166_CR7","doi-asserted-by":"publisher","DOI":"10.1177\/1533034617749418","volume":"17","author":"M Guan","year":"2018","unstructured":"Guan, M., Tong, Y., Guan, M., Liu, X., Wang, M., Niu, R., Zhang, F., Dong, D., Shao, J., & Zhou, Y. (2018). Lapatinib inhibits breast cancer cell proliferation by influencing PKM2 expression. Technology in Cancer Research & Treatment, 17, Article 1533034617749418.","journal-title":"Technology in Cancer Research & Treatment"},{"key":"10166_CR8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/dvdy.24530","volume":"246","author":"SM Ahmad","year":"2017","unstructured":"Ahmad, S. M. (2017). Conserved signaling mechanisms in Drosophila heart development. Developmental Dynamics, 246, 641\u2013656.","journal-title":"Developmental Dynamics"},{"key":"10166_CR9","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1158\/1078-0432.CCR-07-0004","volume":"13","author":"WS Siegel-Lakhai","year":"2007","unstructured":"Siegel-Lakhai, W. S., Beijnen, J. H., Vervenne, W. L., Boot, H., Keessen, M., Versola, M., Koch, K. M., Smith, D. A., Pandite, L., Richel, D. J., & Schellens, J. H. (2007). Phase I pharmacokinetic study of the safety and tolerability of lapatinib (GW572016) in combination with oxaliplatin\/fluorouracil\/leucovorin (FOLFOX4) in patients with solid tumors. Clinical Cancer Research, 13, 4495\u20134502.","journal-title":"Clinical Cancer Research"},{"key":"10166_CR10","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1080\/02841860903229124","volume":"48","author":"GS Orphanos","year":"2009","unstructured":"Orphanos, G. S., Ioannidis, G. N., & Ardavanis, A. G. (2009). Cardiotoxicity induced by tyrosine kinase inhibitors. Acta Oncologica, 48, 964\u2013970.","journal-title":"Acta Oncologica"},{"key":"10166_CR11","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.7150\/thno.23207","volume":"8","author":"WT Hsu","year":"2018","unstructured":"Hsu, W. T., Huang, C. Y., Yen, C. Y. T., Cheng, A. L., & Hsieh, P. C. H. (2018). The HER2 inhibitor lapatinib potentiates doxorubicin-induced cardiotoxicity through iNOS signaling. Theranostics, 8, 3176\u20133188.","journal-title":"Theranostics"},{"key":"10166_CR12","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","volume":"37","author":"JL Zamorano","year":"2016","unstructured":"Zamorano, J. L., Lancellotti, P., Rodriguez Munoz, D., Aboyans, V., Asteggiano, R., Galderisi, M., Habib, G., Lenihan, D. J., Lip, G. Y. H., Lyon, A. R., Lopez Fernandez, T., Mohty, D., Piepoli, M. F., Tamargo, J., Torbicki, A., Suter, T. M., E.S.C.S.D. (2016). 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines: The task force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). European Heart Journal, 37, 2768\u20132801.","journal-title":"European Heart Journal"},{"key":"10166_CR13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., Morrison, B., & Stockwell, B. R. (2012). Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell, 149, 1060\u20131072.","journal-title":"Cell"},{"key":"10166_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","volume":"6","author":"HF Yan","year":"2021","unstructured":"Yan, H. F., Zou, T., Tuo, Q. Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021). Ferroptosis: Mechanisms and links with diseases. Signal transduction and targeted therapy, 6, 49.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10166_CR15","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"X Fang","year":"2019","unstructured":"Fang, X., Wang, H., Han, D., Xie, E., Yang, X., Wei, J., Gu, S., Gao, F., Zhu, N., Yin, X., Cheng, Q., Zhang, P., Dai, W., Chen, J., Yang, F., Yang, H. T., Linkermann, A., Gu, W., Min, J., & Wang, F. (2019). Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A, 116, 2672\u20132680.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10166_CR16","doi-asserted-by":"publisher","first-page":"e2307","DOI":"10.1038\/cddis.2016.208","volume":"7","author":"S Ma","year":"2016","unstructured":"Ma, S., Henson, E. S., Chen, Y., & Gibson, S. B. (2016). Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death & Disease, 7, e2307.","journal-title":"Cell Death & Disease"},{"key":"10166_CR17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.2174\/0118715206327756240830062531","volume":"25","author":"Y Sun","year":"2025","unstructured":"Sun, Y., Wang, D., Yuan, C., Lang, X., & Fu, S. (2025). Lapatinib: A potential therapeutic agent for colon cancer targeting ferroptosis. Anti-Cancer Agents in Medicinal Chemistry, 25, 114\u2013123.","journal-title":"Anti-Cancer Agents in Medicinal Chemistry"},{"key":"10166_CR18","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","volume":"11","author":"HP Harding","year":"2003","unstructured":"Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., Stojdl, D. F., Bell, J. C., Hettmann, T., Leiden, J. M., & Ron, D. (2003). An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell, 11, 619\u2013633.","journal-title":"Molecular Cell"},{"key":"10166_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110412","volume":"98","author":"SW Kim","year":"2022","unstructured":"Kim, S. W., Ahn, B. Y., Tran, T. T. V., Pyun, J. H., Kang, J. S., & Leem, Y. E. (2022). PRMT1 suppresses doxorubicin-induced cardiotoxicity by inhibiting endoplasmic reticulum stress. Cellular Signalling, 98, Article 110412.","journal-title":"Cellular Signalling"},{"key":"10166_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113280","volume":"153","author":"H Jiang","year":"2022","unstructured":"Jiang, H., Wang, C., Zhang, A., Li, Y., Li, J., Li, Z., Yang, X., & Hou, Y. (2022). ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis. Biomedicine & Pharmacotherapy, 153, Article 113280.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10166_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155399","volume":"130","author":"Y Zhou","year":"2024","unstructured":"Zhou, Y., She, R., Mei, Z., Liu, D., & Ge, J. (2024). Crosstalk between ferroptosis and necroptosis in cerebral ischemia\/reperfusion injury and Naotaifang formula exerts neuroprotective effect via HSP90-GCN2-ATF4 pathway. Phytomedicine, 130, Article 155399.","journal-title":"Phytomedicine"},{"key":"10166_CR22","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jhep.2023.03.016","volume":"79","author":"F He","year":"2023","unstructured":"He, F., Zhang, P., Liu, J., Wang, R., Kaufman, R. J., Yaden, B. C., & Karin, M. (2023). ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis. Journal Of Hepatology, 79, 362\u2013377.","journal-title":"Journal of Hepatology"},{"key":"10166_CR23","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88646","volume":"1","author":"M Masuda","year":"2016","unstructured":"Masuda, M., Miyazaki-Anzai, S., Keenan, A. L., Shiozaki, Y., Okamura, K., Chick, W. S., Williams, K., Zhao, X., Rahman, S. M., Tintut, Y., Adams, C. M., & Miyazaki, M. (2016). Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. JCI Insight, 1, Article e88646.","journal-title":"JCI Insight"},{"key":"10166_CR24","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.7150\/thno.36818","volume":"9","author":"J Luo","year":"2019","unstructured":"Luo, J., Xia, Y., Yin, Y., Luo, J., Liu, M., Zhang, H., Zhang, C., Zhao, Y., Yang, L., & Kong, L. (2019). ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma. Theranostics, 9, 6334\u20136353.","journal-title":"Theranostics"},{"key":"10166_CR25","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1172\/JCI42106","volume":"120","author":"H Cao","year":"2010","unstructured":"Cao, H., Yu, S., Yao, Z., Galson, D. L., Jiang, Y., Zhang, X., Fan, J., Lu, B., Guan, Y., Luo, M., Lai, Y., Zhu, Y., Kurihara, N., Patrene, K., Roodman, G. D., & Xiao, G. (2010). Activating transcription factor 4 regulates osteoclast differentiation in mice. The Journal of clinical investigation, 120, 2755\u20132766.","journal-title":"The Journal of Clinical Investigation"},{"key":"10166_CR26","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.bbagrm.2016.07.010","volume":"1859","author":"H Chen","year":"2016","unstructured":"Chen, H., Yuan, R., Zhang, Y., Zhang, X., Chen, L., Zhou, X., Yuan, Z., Nie, Y., Li, M., Mo, D., & Chen, Y. (2016). ATF4 regulates SREBP1c expression to control fatty acids synthesis in 3T3-L1 adipocytes differentiation. Biochimica Et Biophysica Acta, 1859, 1459\u20131469.","journal-title":"Biochimica Et Biophysica Acta"},{"key":"10166_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028203","volume":"7","author":"M Chen","year":"2012","unstructured":"Chen, M., Huang, J., Yang, X., Liu, B., Zhang, W., Huang, L., Deng, F., Ma, J., Bai, Y., Lu, R., Huang, B., Gao, Q., Zhuo, Y., & Ge, J. (2012). Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming. PLoS One, 7, Article e28203.","journal-title":"PLoS One"},{"key":"10166_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1901-x","volume":"10","author":"JA Pan","year":"2019","unstructured":"Pan, J. A., Tang, Y., Yu, J. Y., Zhang, H., Zhang, J. F., Wang, C. Q., & Gu, J. (2019). MiR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b\/P53 pathway in doxorubicin-induced cardiotoxicity. Cell Death & Disease, 10, Article 668.","journal-title":"Cell Death & Disease"},{"key":"10166_CR29","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00395-024-01044-2","volume":"119","author":"GE Xu","year":"2024","unstructured":"Xu, G. E., Yu, P., Hu, Y., Wan, W., Shen, K., Cui, X., Wang, J., Wang, T., Cui, C., Chatterjee, E., Li, G., Cretoiu, D., Sluijter, J. P. G., Xu, J., Wang, L., & Xiao, J. (2024). Exercise training decreases lactylation and prevents myocardial ischemia-reperfusion injury by inhibiting YTHDF2. Basic Research in Cardiology, 119, 651\u2013671.","journal-title":"Basic Research in Cardiology"},{"key":"10166_CR30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.7150\/ntno.96846","volume":"8","author":"A Setia","year":"2024","unstructured":"Setia, A., Challa, R. R., Vallamkonda, B., Satti, P., Mehata, A. K., Priya, V., Kumar, S., & Muthu, M. S. (2024). Nanomedicine And Nanotheranostics: Special Focus on Imaging of Anticancer Drugs Induced Cardiac Toxicity. Nanotheranostics, 8, 473\u2013496.","journal-title":"Nanotheranostics"},{"key":"10166_CR31","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41419-021-03614-x","volume":"12","author":"E Christidi","year":"2021","unstructured":"Christidi, E., & Brunham, L. R. (2021). Regulated cell death pathways in doxorubicin-induced cardiotoxicity. Cell Death And Disease, 12, 339.","journal-title":"Cell Death and Disease"},{"key":"10166_CR32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2174\/157489209789206896","volume":"4","author":"O Obajimi","year":"2009","unstructured":"Obajimi, O. (2009). Lapatinib as a chemotherapeutic drug. Recent Patents on Anti-Cancer Drug Discovery, 4, 216\u2013226.","journal-title":"Recent Patents on Anti-Cancer Drug Discovery"},{"key":"10166_CR33","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1517\/14656566.8.13.2189","volume":"8","author":"A Mukherjee","year":"2007","unstructured":"Mukherjee, A., Dhadda, A. S., Shehata, M., & Chan, S. (2007). Lapatinib: A tyrosine kinase inhibitor with a clinical role in breast cancer. Expert Opinion On Pharmacotherapy, 8, 2189\u20132204.","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"10166_CR34","doi-asserted-by":"publisher","first-page":"6652","DOI":"10.1158\/0008-5472.CAN-04-1168","volume":"64","author":"ER Wood","year":"2004","unstructured":"Wood, E. R., Truesdale, A. T., McDonald, O. B., Yuan, D., Hassell, A., Dickerson, S. H., Ellis, B., Pennisi, C., Horne, E., Lackey, K., Alligood, K. J., Rusnak, D. W., Gilmer, T. M., & Shewchuk, L. (2004). A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Research, 64, 6652\u20136659.","journal-title":"Cancer Research"},{"key":"10166_CR35","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/cncr.21202","volume":"104","author":"A Lipton","year":"2005","unstructured":"Lipton, A., Leitzel, K., Ali, S. M., Demers, L., Harvey, H. A., Chaudri-Ross, H. A., Evans, D., Lang, R., Hackl, W., Hamer, P., & Carney, W. (2005). Serum HER-2\/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy. Cancer, 104, 257\u2013263.","journal-title":"Cancer"},{"key":"10166_CR36","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1200\/JCO.2005.01.172","volume":"23","author":"MC Gutierrez","year":"2005","unstructured":"Gutierrez, M. C., Detre, S., Johnston, S., Mohsin, S. K., Shou, J., Allred, D. C., Schiff, R., Osborne, C. K., & Dowsett, M. (2005). Molecular changes in tamoxifen-resistant breast cancer: Relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase. Journal of Clinical Oncology, 23, 2469\u20132476.","journal-title":"Journal of Clinical Oncology"},{"key":"10166_CR37","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/21655979.2021.2004980","volume":"13","author":"L Sun","year":"2022","unstructured":"Sun, L., Wang, H., Xu, D., Yu, S., Zhang, L., & Li, X. (2022). Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K\/AKT signaling pathway. Bioengineered, 13, 48\u201360.","journal-title":"Bioengineered"},{"key":"10166_CR38","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.7314\/APJCP.2012.13.3.1053","volume":"13","author":"GL Huang","year":"2012","unstructured":"Huang, G. L., Guo, H. Q., Yang, F., Liu, O. F., Li, B. B., Liu, X. Y., Lu, Y., & He, Z. W. (2012). Activating transcription factor 1 is a prognostic marker of colorectal cancer. Asian Pacific Journal of Cancer Prevention, 13, 1053\u20131057.","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"10166_CR39","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/1471-2474-14-209","volume":"14","author":"J Han","year":"2013","unstructured":"Han, J., Guo, X., Tan, W., Zhang, F., Liu, J., Wang, W., Xu, P., & Lammi, M. J. (2013). The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease. Bmc Musculoskeletal Disorders, 14, 209.","journal-title":"BMC Musculoskeletal Disorders"},{"key":"10166_CR40","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1038\/s41388-019-0692-y","volume":"38","author":"S Avraham","year":"2019","unstructured":"Avraham, S., Korin, B., Aviram, S., Shechter, D., Shaked, Y., & Aronheim, A. (2019). ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription. Oncogene, 38, 3812\u20133823.","journal-title":"Oncogene"},{"key":"10166_CR41","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.gendis.2021.04.008","volume":"9","author":"M Chen","year":"2022","unstructured":"Chen, M., Liu, Y., Yang, Y., Qiu, Y., Wang, Z., Li, X., & Zhang, W. (2022). Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy. Genes & Diseases, 9, 981\u2013999.","journal-title":"Genes & Diseases"},{"key":"10166_CR42","doi-asserted-by":"publisher","first-page":"9979291","DOI":"10.1155\/2023\/9979291","volume":"2023","author":"W Zhu","year":"2023","unstructured":"Zhu, W., Li, Y., Li, M., Liu, J., Zhang, G., Ma, X., Shi, W., & Cong, B. (2023). Bioinformatics analysis of molecular interactions between endoplasmic reticulum stress and ferroptosis under stress exposure. Analytical Cellular Pathology, 2023, 9979291.","journal-title":"Analytical Cellular Pathology"},{"key":"10166_CR43","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/CIRCRESAHA.123.323683","volume":"134","author":"G Yan","year":"2024","unstructured":"Yan, G., Han, Z., Kwon, Y., Jousma, J., Nukala, S. B., Prosser, B. L., Du, X., Pinho, S., Ong, S. B., Lee, W. H., & Ong, S. G. (2024). Integrated stress response potentiates ponatinib-induced cardiotoxicity. Circulation Research, 134, 482\u2013501.","journal-title":"Circulation Research"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10166-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-026-10166-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10166-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:02:42Z","timestamp":1787068962000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-026-10166-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10166"],"URL":"https:\/\/doi.org\/10.1007\/s12012-026-10166-z","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"25 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"87"}}