{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:03:21Z","timestamp":1789473801558,"version":"build-2803163510"},"reference-count":181,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Fundamental Research Funds for the Provincial Universities","award":["2025-KYYWF-ZR0237"],"award-info":[{"award-number":["2025-KYYWF-ZR0237"]}]},{"name":"Heilongjiang Provincial Natural Science Foundation Joint Fund Cultivation Project","award":["PL2025H202"],"award-info":[{"award-number":["PL2025H202"]}]},{"name":"the Fundamental Research Funds for the Provincial Universitiesv","award":["2025-KYYWF-ZR0208"],"award-info":[{"award-number":["2025-KYYWF-ZR0208"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s12012-026-10175-y","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:47:27Z","timestamp":1787291247000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardio-Oncology in Cold Climates: Epidemiological Features, Bidirectional Interaction Mechanisms, and Integrated Management Strategies"],"prefix":"10.1007","volume":"26","author":[{"given":"Yuexin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"10175_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/ehf2.12005","volume":"1","author":"P Ponikowski","year":"2014","unstructured":"Ponikowski, P., Anker, S. D., AlHabib, K. F., Cowie, M. R., Force, T. L., Hu, S., Jaarsma, T., Krum, H., Rastogi, V., & Rohde, L. E. (2014). Heart failure: preventing disease and death worldwide. ESC heart failure, 1, 4\u201325.","journal-title":"ESC heart failure"},{"key":"10175_CR2","doi-asserted-by":"crossref","unstructured":"Moslehi, J., Zhang, Q., & Moore, K. J. (2020). Crosstalk between the heart and cancer: beyond drug toxicity, pp 684-687. Lippincott Williams & Wilkins Hagerstown.","DOI":"10.1161\/CIRCULATIONAHA.120.048655"},{"key":"10175_CR3","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1093\/cvr\/cvaa222","volume":"116","author":"CG Tocchetti","year":"2020","unstructured":"Tocchetti, C. G., Ameri, P., De Boer, R. A., D\u2019Alessandra, Y., Russo, M., Sorriento, D., Ciccarelli, M., Kiss, B., Bertrand, L., & Dawson, D. (2020). Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovascular research, 116, 1820\u20131834.","journal-title":"Cardiovascular research"},{"key":"10175_CR4","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/cvr\/cvz035","volume":"115","author":"WC Meijers","year":"2019","unstructured":"Meijers, W. C., & De Boer, R. A. (2019). Common risk factors for heart failure and cancer. Cardiovascular research, 115, 844\u2013853.","journal-title":"Cardiovascular research"},{"key":"10175_CR5","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1161\/CIRCULATIONAHA.115.020406","volume":"133","author":"RJ Koene","year":"2016","unstructured":"Koene, R. J., Prizment, A. E., Blaes, A., & Konety, S. H. (2016). Shared risk factors in cardiovascular disease and cancer. Circulation, 133, 1104\u20131114.","journal-title":"Circulation"},{"key":"10175_CR6","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1002\/ejhf.2029","volume":"22","author":"RA De Boer","year":"2020","unstructured":"De Boer, R. A., Hulot, J. S., Tocchetti, C. G., Aboumsallem, J. P., Ameri, P., Anker, S. D., Bauersachs, J., Bertero, E., Coats, A. J., & \u010celutkien\u0117, J. (2020). Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European journal of heart failure, 22, 2272\u20132289.","journal-title":"European journal of heart failure"},{"key":"10175_CR7","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth, G. A., Mensah, G. A., Johnson, C. O., Addolorato, G., Ammirati, E., Baddour, L. M., Barengo, N. C., Beaton, A. Z., Benjamin, E. J., & Benziger, C. P. (2020). Global burden of cardiovascular diseases and risk factors, 1990\u20132019: Update from the GBD 2019 study. Journal of the American college of cardiology, 76, 2982\u20133021.","journal-title":"Journal of the American college of cardiology"},{"key":"10175_CR8","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, X., Wang, C., & Zhou, J. (2024). Global, regional, and national burden of cardiovascular disease, 1990\u20132021: Results from the 2021 global burden of disease study. Cureus 16.","DOI":"10.7759\/cureus.74333"},{"key":"10175_CR9","doi-asserted-by":"publisher","first-page":"110535","DOI":"10.1016\/j.envres.2020.110535","volume":"193","author":"O Fonseca-Rodr\u00edguez","year":"2021","unstructured":"Fonseca-Rodr\u00edguez, O., Sheridan, S. C., Lundevaller, E. H., & Schumann, B. (2021). Effect of extreme hot and cold weather on cause-specific hospitalizations in Sweden: A time series analysis. Environmental research, 193, 110535.","journal-title":"Environmental research"},{"key":"10175_CR10","doi-asserted-by":"publisher","first-page":"142614","DOI":"10.1016\/j.scitotenv.2020.142614","volume":"756","author":"J Hu","year":"2021","unstructured":"Hu, J., Hou, Z., Xu, Y., Zhou, M., Zhou, C., Xiao, Y., Yu, M., Huang, B., Xu, X., & Lin, L. (2021). Life loss of cardiovascular diseases per death attributable to ambient temperature: A national time series analysis based on 364 locations in China. Science of The Total Environment, 756, 142614.","journal-title":"Science of The Total Environment"},{"key":"10175_CR11","doi-asserted-by":"publisher","first-page":"15791","DOI":"10.1007\/s11356-021-16888-7","volume":"29","author":"LS Lv","year":"2022","unstructured":"Lv, L. S., Zhou, C. L., Jin, D. H., Ma, W. J., Liu, T., Xie, Y. J., Xu, Y. Q., & Zhang, X. E. (2022). Impact of ambient temperature on life loss per death from cardiovascular diseases: a multicenter study in central China. Environmental Science and Pollution Research, 29, 15791\u201315799.","journal-title":"Environmental Science and Pollution Research"},{"key":"10175_CR12","doi-asserted-by":"publisher","first-page":"66335","DOI":"10.1007\/s11356-022-20508-3","volume":"29","author":"E Xu","year":"2022","unstructured":"Xu, E., Li, Y., Li, T., & Li, Q. (2022). Association between ambient temperature and ambulance dispatch: A systematic review and meta-analysis. Environmental Science and Pollution Research, 29, 66335\u201366347.","journal-title":"Environmental Science and Pollution Research"},{"key":"10175_CR13","doi-asserted-by":"publisher","first-page":"113498","DOI":"10.1016\/j.ecoenv.2022.113498","volume":"236","author":"R Xu","year":"2022","unstructured":"Xu, R., Shi, C., Wei, J., Lu, W., Li, Y., Liu, T., Wang, Y., Zhou, Y., Chen, G., & Sun, H. (2022). Cause-specific cardiovascular disease mortality attributable to ambient temperature: A time-stratified case-crossover study in Jiangsu province, China. Ecotoxicology and Environmental Safety, 236, 113498.","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"10175_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.envres.2019.03.044","volume":"173","author":"Q Luo","year":"2019","unstructured":"Luo, Q., Li, S., Guo, Y., Han, X., & Jaakkola, J. J. (2019). A systematic review and meta-analysis of the association between daily mean temperature and mortality in China. Environmental research, 173, 281\u2013299.","journal-title":"Environmental research"},{"key":"10175_CR15","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1161\/CIRCULATIONAHA.108.815860","volume":"120","author":"K Wolf","year":"2009","unstructured":"Wolf, K., Schneider, A., Breitner, S., von Klot, S., Meisinger, C., Cyrys, J., Hymer, H., Wichmann, H. E., & Peters, A. (2009). Air temperature and the occurrence of myocardial infarction in Augsburg. Germany Circulation, 120, 735\u2013742.","journal-title":"Germany Circulation"},{"key":"10175_CR16","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1136\/jech.2010.131458","volume":"66","author":"LA Hopstock","year":"2012","unstructured":"Hopstock, L. A., Fors, A. S., B\u00f8naa, K. H., Mannsverk, J., Nj\u00f8lstad, I., & Wilsgaard, T. (2012). The effect of daily weather conditions on myocardial infarction incidence in a subarctic population: The Troms\u00f8 Study 1974\u20132004. J Epidemiol Community Health, 66, 815\u2013820.","journal-title":"J Epidemiol Community Health"},{"key":"10175_CR17","doi-asserted-by":"publisher","first-page":"173278","DOI":"10.1016\/j.scitotenv.2024.173278","volume":"934","author":"Y Han","year":"2024","unstructured":"Han, Y., Chen, Y., Tang, S., Liu, Y., Zhao, Y., Zhao, X., Lei, J., & Fan, Z. (2024). Association between synoptic types in Beijing and acute myocardial infarction hospitalizations: A comprehensive analysis of environmental factors. Science of The Total Environment, 934, 173278.","journal-title":"Science of The Total Environment"},{"key":"10175_CR18","first-page":"1022","volume":"38","author":"S Liu","year":"2017","unstructured":"Liu, S., Cai, Y., Zeng, X., Yin, P., Qi, J., Liu, Y., Liu, J., Zhao, Z., Zhang, M., & Wang, L. (2017). Deaths and life expectancy losses attributable to diet high in sodium in China. Zhonghua liu Xing Bing xue za zhi=. Zhonghua Liuxingbingxue Zazhi, 38, 1022\u20131027.","journal-title":"Zhonghua Liuxingbingxue Zazhi"},{"key":"10175_CR19","doi-asserted-by":"crossref","unstructured":"He, F. J., Li, J., & MacGregor, G. A. (2013). Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. Bmj 346.","DOI":"10.1002\/14651858.CD004937.pub2"},{"key":"10175_CR20","first-page":"759","volume":"50","author":"M Liu","year":"2016","unstructured":"Liu, M., Li, Y., Liu, S., Wang, L., Liu, Y., Yin, P., Liu, J., You, J., & Zhou, M. (2016). Burden of disease attributable to high-sodium diets in China, 2013. Zhonghua yu Fang yi xue za zhi. [Chinese Journal of Preventive Medicine], 50, 759\u2013763.","journal-title":"[Chinese Journal of Preventive Medicine]"},{"key":"10175_CR21","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1093\/cvr\/cvab173","volume":"118","author":"G Riccardi","year":"2022","unstructured":"Riccardi, G., Giosu\u00e8, A., Calabrese, I., & Vaccaro, O. (2022). Dietary recommendations for prevention of atherosclerosis. Cardiovascular research, 118, 1188\u20131204.","journal-title":"Cardiovascular research"},{"key":"10175_CR22","doi-asserted-by":"crossref","unstructured":"Cesaroni, G., Forastiere, F., Stafoggia, M., Andersen, Z. J., Badaloni, C., Beelen, R., Caracciolo, B., de Faire, U., Erbel, R., & Eriksen, K. T. (2014). Long term exposure to ambient air pollution and incidence of acute coronary events: Prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. Bmj, 348.","DOI":"10.1136\/bmj.f7412"},{"key":"10175_CR23","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1001\/jama.2012.126","volume":"307","author":"H Mustafi\u0107","year":"2012","unstructured":"Mustafi\u0107, H., Jabre, P., Caussin, C., Murad, M. H., Escolano, S., Tafflet, M., P\u00e9rier, M. C., Marijon, E., Vernerey, D., & Empana, J. P. (2012). Main air pollutants and myocardial infarction: A systematic review and meta-analysis. Jama, 307, 713\u2013721.","journal-title":"Jama"},{"key":"10175_CR24","doi-asserted-by":"publisher","first-page":"117002","DOI":"10.1289\/EHP1673","volume":"125","author":"P Yin","year":"2017","unstructured":"Yin, P., Brauer, M., Cohen, A., Burnett, R. T., Liu, J., Liu, Y., Liang, R., Wang, W., Qi, J., & Wang, L. (2017). Long-term fine particulate matter exposure and nonaccidental and cause-specific mortality in a large national cohort of Chinese men. Environmental health perspectives, 125, 117002.","journal-title":"Environmental health perspectives"},{"key":"10175_CR25","doi-asserted-by":"publisher","first-page":"1084611","DOI":"10.3389\/fcvm.2023.1084611","volume":"10","author":"JF Fan","year":"2023","unstructured":"Fan, J. F., Xiao, Y. C., Feng, Y. F., Niu, L. Y., Tan, X., Sun, J. C., Leng, Y. Q., Li, W. Y., Wang, W. Z., & Wang, Y. K. (2023). A systematic review and meta-analysis of cold exposure and cardiovascular disease outcomes. Frontiers in Cardiovascular Medicine, 10, 1084611.","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10175_CR26","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/23328940.2017.1414014","volume":"5","author":"TM Ik\u00e4heimo","year":"2018","unstructured":"Ik\u00e4heimo, T. M. (2018). Cardiovascular diseases, cold exposure and exercise. Temperature, 5, 123\u2013146.","journal-title":"Temperature"},{"key":"10175_CR27","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1161\/01.CIR.79.5.1015","volume":"79","author":"M Juneau","year":"1989","unstructured":"Juneau, M., Johnstone, M., Dempsey, E., & Waters, D. D. (1989). Exercise-induced myocardial ischemia in a cold environment. Effect of antianginal medications. Circulation, 79, 1015\u20131020.","journal-title":"Circulation"},{"key":"10175_CR28","doi-asserted-by":"publisher","first-page":"145046","DOI":"10.1016\/j.scitotenv.2021.145046","volume":"772","author":"S Zheng","year":"2021","unstructured":"Zheng, S., Zhu, W., Shi, Q., Wang, M., Nie, Y., Zhang, D., Cheng, Z., Yin, C., Miao, Q., & Luo, Y. (2021). Effects of cold and hot temperature on metabolic indicators in adults from a prospective cohort study. Science of The Total Environment, 772, 145046.","journal-title":"Science of The Total Environment"},{"key":"10175_CR29","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1002\/cncr.33587","volume":"127","author":"F Bray","year":"2021","unstructured":"Bray, F., Laversanne, M., Weiderpass, E., & Soerjomataram, I. (2021). The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer, 127, 3029\u20133030.","journal-title":"Cancer"},{"key":"10175_CR30","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 74, 229\u2013263.","journal-title":"CA: a cancer journal for clinicians"},{"key":"10175_CR31","doi-asserted-by":"publisher","first-page":"5953","DOI":"10.1007\/s13277-015-3270-0","volume":"36","author":"A Sharma","year":"2015","unstructured":"Sharma, A., Verma, H. K., Joshi, S., Panwar, M. S., & Mandal, C. C. (2015). A link between cold environment and cancer. Tumor Biology, 36, 5953\u20135964.","journal-title":"Tumor Biology"},{"key":"10175_CR32","unstructured":"Ferlay, J., Heanue, M., & Boyle, P. (2007). Cancer incidence in five continents. Vol. IX. IARC Scientific Publication, No. 160. International Agency for Research on Cancer."},{"key":"10175_CR33","doi-asserted-by":"publisher","first-page":"dyae093","DOI":"10.1093\/ije\/dyae093","volume":"53","author":"I Kayyal-Tarabeia","year":"2024","unstructured":"Kayyal-Tarabeia, I., Zick, A., Kloog, I., Levy, I., Blank, M., & Agay-Shay, K. (2024). Beyond lung cancer: Air pollution and bladder, breast and prostate cancer incidence. International Journal of Epidemiology, 53, dyae093.","journal-title":"International Journal of Epidemiology"},{"key":"10175_CR34","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1164\/rccm.202011-4063OC","volume":"204","author":"Y Huang","year":"2021","unstructured":"Huang, Y., Zhu, M., Ji, M., Fan, J., Xie, J., Wei, X., Jiang, X., Xu, J., Chen, L., & Yin, R. (2021). Air pollution, genetic factors, and the risk of lung cancer: A prospective study in the UK Biobank. American journal of respiratory and critical care medicine, 204, 817\u2013825.","journal-title":"American journal of respiratory and critical care medicine"},{"key":"10175_CR35","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/nutrit\/nux012","volume":"75","author":"G Grosso","year":"2017","unstructured":"Grosso, G., Bella, F., Godos, J., Sciacca, S., Del Rio, D., Ray, S., Galvano, F., & Giovannucci, E. L. (2017). Possible role of diet in cancer: Systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutrition reviews, 75, 405\u2013419.","journal-title":"Nutrition reviews"},{"key":"10175_CR36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.2105\/AJPH.2004.045260","volume":"96","author":"CF Garland","year":"2006","unstructured":"Garland, C. F., Garland, F. C., Gorham, E. D., Lipkin, M., Newmark, H., Mohr, S. B., & Holick, M. F. (2006). The role of vitamin D in cancer prevention. American Journal of Public Health, 96, 252\u2013261.","journal-title":"American Journal of Public Health"},{"key":"10175_CR37","doi-asserted-by":"publisher","first-page":"103852","DOI":"10.1016\/j.critrevonc.2022.103852","volume":"180","author":"HT PK","year":"2022","unstructured":"PK, H. T., Unnikrishnan, L., Pangath, M., Vasudevan, K., Jayaraman, S., Li, M., Iyaswamy, A., Palaniyandi, K., & Gnanasampanthapandian, D. (2022). The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review. Critical reviews in oncology\/hematology, 180, 103852.","journal-title":"Critical reviews in oncology\/hematology"},{"key":"10175_CR38","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3390\/cimb47110923","volume":"47","author":"OO Taiwo","year":"2025","unstructured":"Taiwo, O. O., Alaka, W., & Storey, K. B. (2025). Molecular mechanisms of DNA damage response and epigenetic regulation in cold-adapted species: Implications for genome stability and molecular network perspective. Current Issues in Molecular Biology, 47, 923.","journal-title":"Current Issues in Molecular Biology"},{"key":"10175_CR39","doi-asserted-by":"publisher","first-page":"899574","DOI":"10.3389\/fimmu.2022.899574","volume":"13","author":"A Cheong","year":"2022","unstructured":"Cheong, A., & Nagel, Z. D. (2022). Human variation in DNA repair, immune function, and cancer risk. Frontiers in Immunology, 13, 899574.","journal-title":"Frontiers in Immunology"},{"key":"10175_CR40","first-page":"591","volume":"47","author":"YS Kim","year":"2018","unstructured":"Kim, Y. S., Park, D. K., Hwang, I. C., & Ahn, H. Y. (2018). Daily weather conditions and anticipated death from cancer. Iranian Journal of Public Health, 47, 591.","journal-title":"Iranian Journal of Public Health"},{"key":"10175_CR41","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1139\/y98-097","volume":"76","author":"RJ Shephard","year":"1998","unstructured":"Shephard, R. J., & Shek, P. N. (1998). Cold exposure and immune function. Canadian Journal of Physiology and Pharmacology, 76, 828\u2013836.","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"key":"10175_CR42","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/bies.201400066","volume":"36","author":"MN Messmer","year":"2014","unstructured":"Messmer, M. N., Kokolus, K. M., Eng, J. W. L., Abrams, S. I., & Repasky, E. A. (2014). Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice. Bioessays, 36, 884\u2013891.","journal-title":"Bioessays"},{"key":"10175_CR43","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41586-022-05030-3","volume":"608","author":"T Seki","year":"2022","unstructured":"Seki, T., Yang, Y., Sun, X., Lim, S., Xie, S., Guo, Z., Xiong, W., Kuroda, M., Sakaue, H., & Hosaka, K. (2022). Brown-fat-mediated tumour suppression by cold-altered global metabolism. Nature, 608, 421\u2013428.","journal-title":"Nature"},{"key":"10175_CR44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1476-072X-9-19","volume":"9","author":"S St-Hilaire","year":"2010","unstructured":"St-Hilaire, S., Mannel, S., Commendador, A., Mandal, R., & Derryberry, D. (2010). Correlations between meteorological parameters and prostate cancer. International Journal of Health GGeographics, 9, 19.","journal-title":"International Journal of Health GGeographics"},{"key":"10175_CR45","doi-asserted-by":"publisher","first-page":"818","DOI":"10.12659\/MSM.890062","volume":"20","author":"A Ho","year":"2014","unstructured":"Ho, A., Gabriel, A., Bhatnagar, A., Etienne, D., & Loukas, M. (2014). Seasonality pattern of breast, colorectal, and prostate cancer is dependent on latitude. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 20, 818.","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10175_CR46","doi-asserted-by":"publisher","first-page":"1742520","DOI":"10.1080\/22423982.2020.1742520","volume":"79","author":"C Nieder","year":"2020","unstructured":"Nieder, C., Dalhaug, A., & Haukland, E. (2020). Is there a seasonal variation of survival after systemic chemotherapy for metastatic castration-resistant prostate cancer in a rural part of North Norway? International Journal of Circumpolar Health, 79, 1742520.","journal-title":"International Journal of Circumpolar Health"},{"key":"10175_CR47","doi-asserted-by":"publisher","first-page":"6426","DOI":"10.1038\/ncomms7426","volume":"6","author":"JWL Eng","year":"2015","unstructured":"Eng, J. W. L., Reed, C. B., Kokolus, K. M., Pitoniak, R., Utley, A., Bucsek, M. J., Ma, W. W., Repasky, E. A., & Hylander, B. L. (2015). Housing temperature-induced stress drives therapeutic resistance in murine tumour models through \u03b22-adrenergic receptor activation. Nature Communications, 6, 6426.","journal-title":"Nature Communications"},{"key":"10175_CR48","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1172\/JCI68993","volume":"123","author":"AA van der Lans","year":"2013","unstructured":"van der Lans, A. A., Hoeks, J., Brans, B., Vijgen, G. H., Visser, M. G., Vosselman, M. J., Hansen, J., J\u00f6rgensen, J. A., Wu, J., & Mottaghy, F. M. (2013). Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. The Journal of Clinical Investigation, 123, 3395\u20133403.","journal-title":"The Journal of Clinical Investigation"},{"key":"10175_CR49","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1016\/j.cmet.2024.05.011","volume":"36","author":"S Inoue","year":"2024","unstructured":"Inoue, S., Emmett, M. J., Lim, H. W., Midha, M., Richter, H. J., Celwyn, I. J., Mehmood, R., Chondronikola, M., Klein, S., & Hauck, A. K. (2024). Short-term cold exposure induces persistent epigenomic memory in brown fat. Cell Metabolism, 36, 1764\u20131778. e1769.","journal-title":"Cell Metabolism"},{"key":"10175_CR50","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.2337\/db09-0530","volume":"58","author":"M Saito","year":"2009","unstructured":"Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., & Nakada, K. (2009). High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity. Diabetes, 58, 1526\u20131531.","journal-title":"Diabetes"},{"key":"10175_CR51","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10549-017-4282-9","volume":"164","author":"S Gernaat","year":"2017","unstructured":"Gernaat, S., Ho, P., Rijnberg, N., Emaus, M., Baak, L., Hartman, M., Grobbee, D., & Verkooijen, H. (2017). Risk of death from cardiovascular disease following breast cancer: A systematic review. Breast cancer research and treatment, 164, 537\u2013555.","journal-title":"Breast cancer research and treatment"},{"key":"10175_CR52","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jacc.2020.11.020","volume":"77","author":"P Thavendiranathan","year":"2021","unstructured":"Thavendiranathan, P., Negishi, T., Somerset, E., Negishi, K., Penicka, M., Lemieux, J., Aakhus, S., Miyazaki, S., Shirazi, M., & Galderisi, M. (2021). Strain-guided management of potentially cardiotoxic cancer therapy. Journal of the American College of Cardiology, 77, 392\u2013401.","journal-title":"Journal of the American College of Cardiology"},{"key":"10175_CR53","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1001\/jamacardio.2019.2952","volume":"4","author":"EK Oikonomou","year":"2019","unstructured":"Oikonomou, E. K., Kokkinidis, D. G., Kampaktsis, P. N., Amir, E. A., Marwick, T. H., Gupta, D., & Thavendiranathan, P. (2019). Assessment of prognostic value of left ventricular global longitudinal strain for early prediction of chemotherapy-induced cardiotoxicity: A systematic review and meta-analysis. JAMA cardiology, 4, 1007\u20131018.","journal-title":"JAMA cardiology"},{"key":"10175_CR54","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/s41586-022-05432-3","volume":"611","author":"ML Axelrod","year":"2022","unstructured":"Axelrod, M. L., Meijers, W. C., Screever, E. M., Qin, J., Carroll, M. G., Sun, X., Tannous, E., Zhang, Y., Sugiura, A., & Taylor, B. C. (2022). T cells specific for \u03b1-myosin drive immunotherapy-related myocarditis. Nature, 611, 818\u2013826.","journal-title":"Nature"},{"key":"10175_CR55","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11912-018-0708-8","volume":"20","author":"M Agarwal","year":"2018","unstructured":"Agarwal, M., Thareja, N., Benjamin, M., Akhondi, A., & Mitchell, G. D. (2018). Tyrosine kinase inhibitor-induced hypertension. Current Oncology Reports, 20, 65.","journal-title":"Current Oncology Reports"},{"key":"10175_CR56","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/1120009X.2023.2300217","volume":"36","author":"MA Manavi","year":"2024","unstructured":"Manavi, M. A., Fathian Nasab, M. H., Mohammad Jafari, R., & Dehpour, A. R. (2024). Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents. Journal of Chemotherapy, 36, 623\u2013653.","journal-title":"Journal of Chemotherapy"},{"key":"10175_CR57","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s12012-024-09834-9","volume":"24","author":"M Rajaeinejad","year":"2024","unstructured":"Rajaeinejad, M., Parhizkar-Roudsari, P., Khoshfetrat, M., Kazemi-Galougahi, M. H., Mosaed, R., Arjmand, R., Mohsenizadeh, S. A., & Arjmand, B. (2024). Management of fluoropyrimidine-induced cardiac adverse outcomes following cancer treatment. Cardiovascular Toxicology, 24, 184\u2013198.","journal-title":"Cardiovascular Toxicology"},{"key":"10175_CR58","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41408-023-00849-z","volume":"13","author":"J El-Cheikh","year":"2023","unstructured":"El-Cheikh, J., Moukalled, N., Malard, F., Bazarbachi, A., & Mohty, M. (2023). Cardiac toxicities in multiple myeloma: An updated and a deeper look into the effect of different medications and novel therapies. Blood Cancer Journal, 13, 83.","journal-title":"Blood Cancer Journal"},{"key":"10175_CR59","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1093\/cvr\/cvz025","volume":"115","author":"N Grabie","year":"2019","unstructured":"Grabie, N., Lichtman, A. H., & Padera, R. (2019). T cell checkpoint regulators in the heart. Cardiovascular Research, 115, 869\u2013877.","journal-title":"Cardiovascular Research"},{"key":"10175_CR60","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1111\/j.1600-6143.2012.04032.x","volume":"12","author":"N Poirier","year":"2012","unstructured":"Poirier, N., Blancho, G., & Vanhove, B. (2012). CD28-specific immunomodulating antibodies: What can be learned from experimental models? American Journal of Transplantation, 12, 1682\u20131690.","journal-title":"American Journal of Transplantation"},{"key":"10175_CR61","doi-asserted-by":"publisher","first-page":"e1765","DOI":"10.1038\/cddis.2015.91","volume":"6","author":"X Liang","year":"2015","unstructured":"Liang, X., Ding, Y., Zhang, Y., Chai, Y., He, J., Chiu, S., Gao, F., Tse, H., & Lian, Q. (2015). Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction. Cell Death & Disease, 6, e1765\u2013e1765.","journal-title":"Cell Death & Disease"},{"key":"10175_CR62","doi-asserted-by":"publisher","first-page":"H443","DOI":"10.1152\/ajpheart.00176.2020","volume":"319","author":"L Dugaucquier","year":"2020","unstructured":"Dugaucquier, L., Feyen, E., Mateiu, L., Bruyns, T. A. M., De Keulenaer, G. W., & Segers, V. F. (2020). The role of endothelial autocrine NRG1\/ERBB4 signaling in cardiac remodeling. American Journal of Physiology-Heart and Circulatory Physiology, 319, H443\u2013H455.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10175_CR63","doi-asserted-by":"crossref","unstructured":"Talmage, D. A. (2008). Mechanisms of neuregulin action, in Growth Factors and Psychiatric Disorders: Novartis Foundation Symposium 289, pp 74-86, Wiley Online Library.","DOI":"10.1002\/9780470751251.ch6"},{"key":"10175_CR64","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/CIRCRESAHA.123.323321","volume":"133","author":"J Grego-Bessa","year":"2023","unstructured":"Grego-Bessa, J., G\u00f3mez-Api\u00f1aniz, P., Prados, B., G\u00f3mez, M. J., MacGrogan, D., & de la Pompa, J. L. (2023). Nrg1 regulates cardiomyocyte migration and cell cycle in ventricular development. Circulation research, 133, 927\u2013943.","journal-title":"Circulation research"},{"key":"10175_CR65","doi-asserted-by":"publisher","first-page":"H2139","DOI":"10.1152\/ajpheart.00063.2012","volume":"302","author":"B Wadugu","year":"2012","unstructured":"Wadugu, B., & K\u00fchn, B. (2012). The role of neuregulin\/ErbB2\/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. American Journal of Physiology-Heart and Circulatory Physiology, 302, H2139\u2013H2147.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10175_CR66","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.yjmcc.2008.10.010","volume":"46","author":"K Doggen","year":"2009","unstructured":"Doggen, K., Ray, L., Mathieu, M., Mc Entee, K., Lemmens, K., & De Keulenaer, G. W. (2009). Ventricular ErbB2\/ErbB4 activation and downstream signaling in pacing-induced heart failure. Journal of Molecular and Cellular Cardiology, 46, 33\u201338.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10175_CR67","doi-asserted-by":"publisher","first-page":"H1271","DOI":"10.1152\/ajpheart.00517.2014","volume":"309","author":"F Belmonte","year":"2015","unstructured":"Belmonte, F., Das, S., Sysa-Shah, P., Sivakumaran, V., Stanley, B., Guo, X., Paolocci, N., Aon, M. A., Nagane, M., & Kuppusamy, P. (2015). ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. American Journal of Physiology-Heart and Circulatory Physiology, 309, H1271\u2013H1280.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10175_CR68","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.freeradbiomed.2023.06.019","volume":"206","author":"T Ye","year":"2023","unstructured":"Ye, T., Yang, W., Gao, T., Yu, X., Chen, T., Yang, Y., Guo, J., Li, Q., Li, H., & Yang, L. (2023). Trastuzumab-induced cardiomyopathy via ferroptosis-mediated mitochondrial dysfunction. Free Radical Biology and Medicine, 206, 143\u2013161.","journal-title":"Free Radical Biology and Medicine"},{"key":"10175_CR69","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1097\/01.sla.0000216770.23642.d8","volume":"243","author":"K Byrnes","year":"2006","unstructured":"Byrnes, K., White, S., Chu, Q., Meschonat, C., Yu, H., Johnson, L. W., DeBenedetti, A., Abreo, F., Turnage, R. H., & McDonald, J. C. (2006). High eIF4E, VEGF, and microvessel density in stage I to III breast cancer. Annals of surgery, 243, 684\u2013692.","journal-title":"Annals of surgery"},{"key":"10175_CR70","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.ejca.2009.04.007","volume":"45","author":"M Raica","year":"2009","unstructured":"Raica, M., Cimpean, A. M., & Ribatti, D. (2009). Angiogenesis in pre-malignant conditions. European Journal of Cancer, 45, 1924\u20131934.","journal-title":"European Journal of Cancer"},{"key":"10175_CR71","first-page":"2393","volume":"118","author":"Y Kubota","year":"2008","unstructured":"Kubota, Y., Hirashima, M., Kishi, K., Stewart, C. L., & Suda, T. (2008). Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. The Journal of Clinical Investigation, 118, 2393\u20132403.","journal-title":"The Journal of Clinical Investigation"},{"key":"10175_CR72","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1161\/HYPERTENSIONAHA.117.08856","volume":"70","author":"RM Touyz","year":"2017","unstructured":"Touyz, R. M., Lang, N. N., Herrmann, J., Van Den Meiracker, A. H., & Danser, A. J. (2017). Recent advances in hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition. Hypertension, 70, 220\u2013226.","journal-title":"Hypertension"},{"key":"10175_CR73","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1093\/cvr\/cvz022","volume":"115","author":"J Versmissen","year":"2019","unstructured":"Versmissen, J., Mirabito Colafella, K. M., Koolen, S. L., & Danser, A. J. (2019). Vascular cardio-oncology: Vascular endothelial growth factor inhibitors and hypertension. Cardiovascular Research, 115, 904\u2013914.","journal-title":"Cardiovascular Research"},{"key":"10175_CR74","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.redox.2015.09.007","volume":"6","author":"L Le\u00f3n-Mateos","year":"2015","unstructured":"Le\u00f3n-Mateos, L., Mosquera, J., & Aparicio, L. A. (2015). Treatment of sunitinib-induced hypertension in solid tumor by nitric oxide donors. Redox Biology, 6, 421\u2013425.","journal-title":"Redox Biology"},{"key":"10175_CR75","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1161\/HYPERTENSIONAHA.117.10490","volume":"71","author":"KB Neves","year":"2018","unstructured":"Neves, K. B., Rios, F. J., Van Der Mey, L., Alves-Lopes, R., Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C., & Touyz, R. M. (2018). VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71, 638\u2013647.","journal-title":"Hypertension"},{"key":"10175_CR76","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/nm1446","volume":"12","author":"R Kerkel\u00e4","year":"2006","unstructured":"Kerkel\u00e4, R., Grazette, L., Yacobi, R., Iliescu, C., Patten, R., Beahm, C., Walters, B., Shevtsov, S., Pesant, S., & Clubb, F. J. (2006). Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nature medicine, 12, 908\u2013916.","journal-title":"Nature medicine"},{"key":"10175_CR77","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1172\/JCI35660","volume":"119","author":"C Bellodi","year":"2009","unstructured":"Bellodi, C., Lidonnici, M. R., Hamilton, A., Helgason, G. V., Soliera, A. R., Ronchetti, M., Galavotti, S., Young, K. W., Selmi, T., & Yacobi, R. (2009). Targeting autophagy potentiates tyrosine kinase inhibitor\u2013induced cell death in Philadelphia chromosome\u2013positive cells, including primary CML stem cells. The Journal of Clinical Investigation, 119, 1109\u20131123.","journal-title":"The Journal of Clinical Investigation"},{"key":"10175_CR78","doi-asserted-by":"publisher","first-page":"5209","DOI":"10.1158\/1078-0432.CCR-08-0374","volume":"14","author":"A Zannetti","year":"2008","unstructured":"Zannetti, A., Iommelli, F., Fonti, R., Papaccioli, A., Sommella, J., Lettieri, A., Pirozzi, G., Bianco, R., Tortora, G., & Salvatore, M. (2008). Gefitinib induction of in vivo detectable signals by Bcl-2\/Bcl-xL modulation of inositol trisphosphate receptor type 3. Clinical Cancer Research, 14, 5209\u20135219.","journal-title":"Clinical Cancer Research"},{"key":"10175_CR79","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1161\/CIRCRESAHA.122.321504","volume":"132","author":"S Tousif","year":"2023","unstructured":"Tousif, S., Singh, A. P., Umbarkar, P., Galindo, C., Wheeler, N., Cora, T., Zhang, A., Prabhu, Q., S.D. and, & Lal, H. (2023). Ponatinib drives cardiotoxicity by S100A8\/A9-NLRP3-IL-1\u03b2 mediated inflammation. Circulation Research, 132, 267\u2013289.","journal-title":"Circulation Research"},{"key":"10175_CR80","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1161\/CIRCRESAHA.123.323683","volume":"134","author":"G Yan","year":"2024","unstructured":"Yan, G., Han, Z., Kwon, Y., Jousma, J., Nukala, S. B., Prosser, B. L., Du, X., Pinho, S., Ong, S. B., & Lee, W. H. (2024). Integrated stress response potentiates ponatinib-induced cardiotoxicity. Circulation Research, 134, 482\u2013501.","journal-title":"Circulation Research"},{"key":"10175_CR81","doi-asserted-by":"publisher","first-page":"eaaf2584","DOI":"10.1126\/scitranslmed.aaf2584","volume":"9","author":"A Sharma","year":"2017","unstructured":"Sharma, A., Burridge, P. W., McKeithan, W. L., Serrano, R., Shukla, P., Sayed, N., Churko, J. M., Kitani, T., Wu, H., & Holmstr\u00f6m, A. (2017). High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells. Science Translational Medicine, 9, eaaf2584.","journal-title":"Science Translational Medicine"},{"key":"10175_CR82","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/cvr\/cvz006","volume":"115","author":"AP Singh","year":"2019","unstructured":"Singh, A. P., Glennon, M. S., Umbarkar, P., Gupte, M., Galindo, C. L., Zhang, Q., Force, T., Becker, J. R., & Lal, H. (2019). Ponatinib-induced cardiotoxicity: Delineating the signalling mechanisms and potential rescue strategies. Cardiovascular research, 115, 966\u2013977.","journal-title":"Cardiovascular research"},{"key":"10175_CR83","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.3390\/ijms23031912","volume":"23","author":"BB Wu","year":"2022","unstructured":"Wu, B. B., Leung, K. T., & Poon, E. N. Y. (2022). Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity. International Journal of Molecular Sciences, 23, 1912.","journal-title":"International Journal of Molecular Sciences"},{"key":"10175_CR84","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/cvr\/cvt021","volume":"98","author":"RM Shaw","year":"2013","unstructured":"Shaw, R. M., & Colecraft, H. M. (2013). L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovascular Research, 98, 177\u2013186.","journal-title":"Cardiovascular Research"},{"key":"10175_CR85","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.yjmcc.2010.08.018","volume":"49","author":"K Zhang","year":"2010","unstructured":"Zhang, K., Heidrich, F. M., DeGray, B., Boehmerle, W., & Ehrlich, B. E. (2010). Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R. Journal of Molecular and Cellular Cardiology, 49, 829\u2013835.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10175_CR86","doi-asserted-by":"publisher","first-page":"144","DOI":"10.47487\/apcyccv.v6i3.502","volume":"6","author":"MJ Santa-Ana-Bayona","year":"2025","unstructured":"Santa-Ana-Bayona, M. J., Ponce-Acosta, C., Quispe-Silvestre, E., Acosta-Guti\u00e9rrez, G. H., Gonz\u00e1lez-Trejo, A., Valencia-Hern\u00e1ndez, H. A., Guerra, E. C., Alarc\u00f3n-Toxqui, P. O., Mart\u00ednez-Ba\u00f1agas, K., & Espinola-Zavaleta, N. (2025). Immune checkpoint inhibitor-induced myocarditis: A comprehensive review with clinical case insights. Archivos peruanos de cardiolog\u00eda y cirug\u00eda cardiovascular, 6, 144.","journal-title":"Archivos peruanos de cardiolog\u00eda y cirug\u00eda cardiovascular"},{"key":"10175_CR87","doi-asserted-by":"publisher","first-page":"e035689","DOI":"10.1161\/JAHA.124.035689","volume":"14","author":"AC Lindsay","year":"2025","unstructured":"Lindsay, A. C., Walker, A. M., & Schneeweiss, S. (2025). Myocarditis in patients starting combination checkpoint inhibitor therapy: Analysis of a commercial claims database. Journal of the American Heart Association, 14, e035689.","journal-title":"Journal of the American Heart Association"},{"key":"10175_CR88","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1200\/JCO.2002.20.5.1215","volume":"20","author":"A Seidman","year":"2002","unstructured":"Seidman, A., Hudis, C., Pierri, M. K., Shak, S., Paton, V., Ashby, M., Murphy, M., Stewart, S. J., & Keefe, D. (2002). Cardiac dysfunction in the trastuzumab clinical trials experience. Journal of Clinical Oncology, 20, 1215\u20131221.","journal-title":"Journal of Clinical Oncology"},{"key":"10175_CR89","doi-asserted-by":"crossref","unstructured":"Blackwell, K. L., Miles, D., Gianni, L., Krop, I. E., Welslau, M., Baselga, J., Pegram, M. D., Oh, D. Y., Dieras, V., & Olsen, S. R. (2012). Primary results from EMILIA, a phase III study of trastuzumab emtansine (T-DM1) versus capecitabine (X) and lapatinib (L) in HER2-positive locally advanced or metastatic breast cancer (MBC) previously treated with trastuzumab (T) and a taxane. American Society of Clinical Oncology.","DOI":"10.1200\/jco.2012.30.18_suppl.lba1"},{"key":"10175_CR90","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1200\/JCO.20.03398","volume":"39","author":"SM Tolaney","year":"2021","unstructured":"Tolaney, S. M., Tayob, N., Dang, C., Yardley, D. A., Isakoff, S. J., Valero, V., Faggen, M., Mulvey, T., Bose, R., & Hu, J. (2021). Adjuvant trastuzumab emtansine versus paclitaxel in combination with trastuzumab for stage I HER2-positive breast cancer (ATEMPT): a randomized clinical trial. Journal of Clinical Oncology, 39, 2375\u20132385.","journal-title":"Journal of Clinical Oncology"},{"key":"10175_CR91","doi-asserted-by":"publisher","first-page":"e2540336","DOI":"10.1001\/jamanetworkopen.2025.40336","volume":"8","author":"L Seth","year":"2025","unstructured":"Seth, L., Bhave, A., Kollapaneni, S., Shah, V., Nahle, T., Blaes, A., Dent, S., Hurvitz, S. A., & Guha, A. (2025). Cardiotoxic effects of antibody drug conjugates vs standard chemotherapy in ERBB2-positive advanced breast cancer: A systematic review and meta-analysis. JAMA Network Open, 8, e2540336.","journal-title":"JAMA Network Open"},{"key":"10175_CR92","doi-asserted-by":"publisher","first-page":"101613","DOI":"10.1016\/j.esmoop.2023.101613","volume":"8","author":"L Soares","year":"2023","unstructured":"Soares, L., Vilbert, M., Rosa, V., Oliveira, J., Deus, M., & Freitas-Junior, R. (2023). Incidence of interstitial lung disease and cardiotoxicity with trastuzumab deruxtecan in breast cancer patients: A systematic review and single-arm meta-analysis. ESMO open, 8, 101613.","journal-title":"ESMO open"},{"key":"10175_CR93","doi-asserted-by":"publisher","first-page":"1492203","DOI":"10.3389\/fonc.2024.1492203","volume":"14","author":"X Zhang","year":"2025","unstructured":"Zhang, X., Yin, Y., Yu, Q., Chen, X., & Cheng, Y. (2025). Review of the clinical status of cardiotoxicity of HER-2 positive breast cancer targeted therapeutic drugs. Frontiers in Oncology, 14, 1492203.","journal-title":"Frontiers in Oncology"},{"key":"10175_CR94","doi-asserted-by":"publisher","first-page":"e46","DOI":"10.1161\/HYP.0000000000000224","volume":"80","author":"JB Cohen","year":"2023","unstructured":"Cohen, J. B., Brown, N. J., Brown, S. A., Dent, S., Van Dorst, D. C., Herrmann, S. M., Lang, N. N., Oudit, G. Y., Touyz, R. M., & Disease, C.o.t.K.i.C. (2023). Cancer therapy\u2013related hypertension: A scientific statement from the American Heart Association. Hypertension, 80, e46\u2013e57.","journal-title":"Hypertension"},{"key":"10175_CR95","doi-asserted-by":"crossref","unstructured":"Aghel, N., & Lipton, J. H. (2025). Cardiovascular disease in patients with chronic myeloid leukemia: JACC: CardioOncology state-of-the-art review. CardioOncology.","DOI":"10.1016\/j.jaccao.2025.06.007"},{"key":"10175_CR96","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1200\/JCO.2015.62.4718","volume":"33","author":"JJ Moslehi","year":"2015","unstructured":"Moslehi, J. J., & Deininger, M. (2015). Tyrosine kinase inhibitor\u2013associated cardiovascular toxicity in chronic myeloid leukemia. Journal of clinical oncology, 33, 4210\u20134218.","journal-title":"Journal of clinical oncology"},{"key":"10175_CR97","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1002\/cncr.11407","volume":"97","author":"SM Swain","year":"2003","unstructured":"Swain, S. M., Whaley, F. S., & Ewer, M. S. (2003). Congestive heart failure in patients treated with doxorubicin: A retrospective analysis of three trials. Cancer: Interdisciplinary International Journal of the American Cancer Society, 97, 2869\u20132879.","journal-title":"Cancer: Interdisciplinary International Journal of the American Cancer Society"},{"key":"10175_CR98","first-page":"e005443","volume":"10","author":"V Buza","year":"2017","unstructured":"Buza, V., Rajagopalan, B., & Curtis, A. B. (2017). Cancer treatment\u2013induced arrhythmias: Focus on chemotherapy and targeted therapies. Circulation: Arrhythmia and Electrophysiology, 10, e005443.","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"key":"10175_CR99","doi-asserted-by":"publisher","first-page":"580811","DOI":"10.3389\/fphys.2020.580811","volume":"11","author":"X Kong","year":"2020","unstructured":"Kong, X., Liu, H., He, X., Sun, Y., & Ge, W. (2020). Unraveling the mystery of cold stress-induced myocardial injury. Frontiers in physiology, 11, 580811.","journal-title":"Frontiers in physiology"},{"key":"10175_CR100","doi-asserted-by":"publisher","first-page":"1740919","DOI":"10.3389\/fphys.2025.1740919","volume":"16","author":"Y Li","year":"2025","unstructured":"Li, Y., Wu, J., Xu, Y., Dong, J., Xing, B., Wang, Y., Zhou, Z., Sun, B., Li, J., & Yu, L. (2025). Cold exposure and the cardiovascular system: From physiological adaptation to pathological risk. Frontiers in Physiology, 16, 1740919.","journal-title":"Frontiers in Physiology"},{"key":"10175_CR101","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3390\/life13020366","volume":"13","author":"D Mihalcea","year":"2023","unstructured":"Mihalcea, D., Memis, H., Mihaila, S., & Vinereanu, D. (2023). Cardiovascular toxicity induced by vascular endothelial growth factor inhibitors. Life, 13, 366.","journal-title":"Life"},{"key":"10175_CR102","doi-asserted-by":"publisher","first-page":"1242596","DOI":"10.3389\/fcvm.2023.1242596","volume":"10","author":"Y Qiu","year":"2023","unstructured":"Qiu, Y., Jiang, P., & Huang, Y. (2023). Anthracycline-induced cardiotoxicity: Mechanisms, monitoring, and prevention. Frontiers in cardiovascular medicine, 10, 1242596.","journal-title":"Frontiers in cardiovascular medicine"},{"key":"10175_CR103","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.1469-7793.1999.0409v.x","volume":"516","author":"F Howarth","year":"1999","unstructured":"Howarth, F., Calaghan, S., Boyett, M., & White, E. (1999). Effect of the microtubule polymerizing agent taxol on contraction, Ca2\u2009+\u2009transient and L-type Ca2\u2009+\u2009current in rat ventricular myocytes. The Journal of Physiology, 516, 409.","journal-title":"The Journal of Physiology"},{"key":"10175_CR104","doi-asserted-by":"publisher","first-page":"896792","DOI":"10.3389\/fcvm.2022.896792","volume":"9","author":"G Zhang","year":"2022","unstructured":"Zhang, G., Yuan, C., Su, X., Zhang, J., Gokulnath, P., Vulugundam, G., Li, G., Yang, X., An, N., & Liu, C. (2022). Relevance of ferroptosis to cardiotoxicity caused by anthracyclines: Mechanisms to target treatments. Frontiers in Cardiovascular Medicine, 9, 896792.","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10175_CR105","doi-asserted-by":"publisher","first-page":"e70358","DOI":"10.1111\/jcmm.70358","volume":"29","author":"J Lian","year":"2025","unstructured":"Lian, J., Lin, H., Zhong, Z., Song, Y., Shao, X., Zhou, J., Xu, L., Sun, Z., Yang, Y., & Chi, J. (2025). Indole-3\u2010Lactic acid inhibits doxorubicin\u2010induced ferroptosis through activating aryl hydrocarbon receptor\/nrf2 signalling pathway. Journal of Cellular and Molecular Medicine, 29, e70358.","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"10175_CR106","doi-asserted-by":"publisher","first-page":"808480","DOI":"10.3389\/fphar.2021.808480","volume":"12","author":"D Li","year":"2022","unstructured":"Li, D., Liu, X., Pi, W., Zhang, Y., Yu, L., Xu, C., Sun, Z., & Jiang, J. (2022). Fisetin attenuates doxorubicin-induced cardiomyopathy in vivo and in vitro by inhibiting ferroptosis through SIRT1\/Nrf2 signaling pathway activation. Frontiers in Pharmacology, 12, 808480.","journal-title":"Frontiers in Pharmacology"},{"key":"10175_CR107","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3390\/antiox12020457","volume":"12","author":"G Mendez-Valdes","year":"2023","unstructured":"Mendez-Valdes, G., Gomez-Hevia, F., Bragato, M. C., Lillo-Moya, J., Rojas-Sole, C., Saso, L., & Rodrigo, R. (2023). Antioxidant protection against trastuzumab cardiotoxicity in breast cancer therapy. Antioxidants, 12, 457.","journal-title":"Antioxidants"},{"key":"10175_CR108","doi-asserted-by":"publisher","first-page":"e2","DOI":"10.4142\/jvs.22185","volume":"24","author":"H Lv","year":"2022","unstructured":"Lv, H., He, Y., Wu, J., Zhen, L., & Zheng, Y. (2022). Chronic cold stress-induced myocardial injury: Effects on oxidative stress, inflammation and pyroptosis. Journal of Veterinary Science, 24, e2.","journal-title":"Journal of Veterinary Science"},{"key":"10175_CR109","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12872-018-0748-x","volume":"18","author":"P Cong","year":"2018","unstructured":"Cong, P., Liu, Y., Liu, N., Zhang, Y., Tong, C., Shi, L., Liu, X., Shi, X., Liu, Y., & Tong, Z. (2018). Cold exposure induced oxidative stress and apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway. BMC Cardiovascular Disorders, 18, 36.","journal-title":"BMC Cardiovascular Disorders"},{"key":"10175_CR110","doi-asserted-by":"publisher","first-page":"6640","DOI":"10.1038\/s41467-024-50996-5","volume":"15","author":"SJ Sun","year":"2024","unstructured":"Sun, S. J., Jiao, X. D., Chen, Z. G., Cao, Q., Zhu, J. H., Shen, Q. R., Liu, Y., Zhang, Z., Xu, F. F., & Shi, Y. (2024). Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation. Nature Communications, 15, 6640.","journal-title":"Nature Communications"},{"key":"10175_CR111","doi-asserted-by":"crossref","unstructured":"Zhang, H., Lin, J., Shen, Y., Pan, J., Wang, C., & Cheng, L. (2022). Protective effect of crocin on immune checkpoint inhibitors-related myocarditis through inhibiting NLRP3 mediated pyroptosis in cardiomyocytes via NF-\u03baB pathway. Journal of Inflammation Research, 15, 1653\u20131666.","DOI":"10.2147\/JIR.S348464"},{"key":"10175_CR112","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s12012-023-09823-4","volume":"24","author":"Z Pei","year":"2024","unstructured":"Pei, Z., Xiong, Y., Jiang, S., Guo, R., Jin, W., Tao, J., Zhang, Z., Zhang, Y., Zou, Y., & Gong, Y. (2024). Heavy metal scavenger metallothionein rescues against cold stress-evoked myocardial contractile anomalies through regulation of mitophagy. Cardiovascular Toxicology, 24, 85\u2013101.","journal-title":"Cardiovascular Toxicology"},{"key":"10175_CR113","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1517\/17425255.2011.574127","volume":"7","author":"J Zhou","year":"2011","unstructured":"Zhou, J., & Poloyac, S. M. (2011). The effect of therapeutic hypothermia on drug metabolism and response: Cellular mechanisms to organ function. Expert opinion on drug metabolism & toxicology, 7, 803\u2013816.","journal-title":"Expert opinion on drug metabolism & toxicology"},{"key":"10175_CR114","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1124\/dmd.111.040642","volume":"39","author":"J Zhou","year":"2011","unstructured":"Zhou, J., Empey, P. E., Bies, R. R., Kochanek, P. M., & Poloyac, S. M. (2011). Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism. Drug Metabolism and Disposition, 39, 2209\u20132218.","journal-title":"Drug Metabolism and Disposition"},{"key":"10175_CR115","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1080\/00498254.2023.2248498","volume":"53","author":"M Kojima","year":"2023","unstructured":"Kojima, M., Machida, K., Cho, S., Watanabe, D., Seki, H., Shimoji, M., Imaoka, A., Yamazaki, H., Guengerich, F. P., & Nakamura, K. (2023). The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro. Xenobiotica, 53, 357\u2013365.","journal-title":"Xenobiotica"},{"key":"10175_CR116","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1007\/s11010-022-04656-1","volume":"478","author":"MS Mohan","year":"2023","unstructured":"Mohan, M. S., Aswani, S., Aparna, N., Boban, P., Sudhakaran, P., & Saja, K. (2023). Effect of acute cold exposure on cardiac mitochondrial function: role of sirtuins. Molecular and Cellular Biochemistry, 478, 2257\u20132270.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10175_CR117","doi-asserted-by":"publisher","first-page":"H1162","DOI":"10.1152\/ajpheart.00001.2024","volume":"327","author":"R Zhou","year":"2024","unstructured":"Zhou, R., Barnes, K., Gibson, S., & Fillmore, N. (2024). Dual-edged role of SIRT1 in energy metabolism and cardiovascular disease. American Journal of Physiology-Heart and Circulatory Physiology, 327, H1162\u2013H1173.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10175_CR118","doi-asserted-by":"publisher","first-page":"3659278","DOI":"10.1155\/2022\/3659278","volume":"2022","author":"Y Li","year":"2022","unstructured":"Li, Y., Lin, R., Peng, X., Wang, X., Liu, X., Li, L., Bai, R., Wen, S., Ruan, Y., & Chang, X. (2022). The role of mitochondrial quality control in anthracycline-induced cardiotoxicity: From bench to bedside. Oxidative Medicine and Cellular Longevity, 2022, 3659278.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10175_CR119","doi-asserted-by":"publisher","first-page":"H1508","DOI":"10.1152\/ajpheart.00377.2025","volume":"329","author":"ML Ndzie Noah","year":"2025","unstructured":"Ndzie Noah, M. L., Nath, N. D., & Yoshioka, J. (2025). Chemotherapy-induced cardiotoxicity in breast cancer: Mechanisms, diagnostic advances, and emerging protective strategies. American Journal of Physiology-Heart and Circulatory Physiology, 329, H1508\u2013H1525.","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10175_CR120","doi-asserted-by":"publisher","first-page":"571659","DOI":"10.3389\/fendo.2020.571659","volume":"11","author":"BT McNeill","year":"2020","unstructured":"McNeill, B. T., Morton, N. M., & Stimson, R. H. (2020). Substrate utilization by brown adipose tissue: What\u2019s hot and what\u2019s not? Frontiers in Endocrinology, 11, 571659.","journal-title":"Frontiers in Endocrinology"},{"key":"10175_CR121","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1161\/CIRCRESAHA.116.310115","volume":"120","author":"H Taegtmeyer","year":"2017","unstructured":"Taegtmeyer, H., Karlstaedt, A., Rees, M. L., & Davogustto, G. (2017). Oncometabolic tracks in the heart. Circulation Research, 120, 267\u2013269.","journal-title":"Circulation Research"},{"key":"10175_CR122","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.3390\/biomedicines13081900","volume":"13","author":"S\u00c8 Thibodeau","year":"2025","unstructured":"Thibodeau, S. \u00c8., Legros, M. L., Labb\u00e9, E. A., Walsh-Wilkinson, \u00c9., Morin-Grandmont, A., Beji, S., Arsenault, M., Caron, A., & Couet, J. (2025). Cold exposure exacerbates cardiac dysfunction in a model of heart failure with preserved ejection fraction in male and female C57Bl\/6J mice. Biomedicines, 13, 1900.","journal-title":"Biomedicines"},{"key":"10175_CR123","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1093\/cvr\/cvz058","volume":"115","author":"P Libby","year":"2019","unstructured":"Libby, P., & Kobold, S. (2019). Inflammation: A common contributor to cancer, aging, and cardiovascular diseases\u2014expanding the concept of cardio-oncology. Cardiovascular research, 115, 824\u2013829.","journal-title":"Cardiovascular research"},{"key":"10175_CR124","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1126\/science.1203543","volume":"331","author":"CL Chaffer","year":"2011","unstructured":"Chaffer, C. L., & Weinberg, R. A. (2011). A perspective on cancer cell metastasis. science, 331, 1559\u20131564.","journal-title":"science"},{"key":"10175_CR125","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1146\/annurev.cb.09.110193.002545","volume":"9","author":"WG Stetler-Stevenson","year":"1993","unstructured":"Stetler-Stevenson, W. G., Aznavoorian, S., & Liotta, L. A. (1993). Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annual Review of Cell Biology, 9, 541\u2013573.","journal-title":"Annual Review of Cell Biology"},{"key":"10175_CR126","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/01.RES.75.1.181","volume":"75","author":"ZS Galis","year":"1994","unstructured":"Galis, Z. S., Muszynski, M., Sukhova, G. K., Simon-Morrissey, E., Unemori, E. N., Lark, M. W., Amento, E., & Libby, P. (1994). Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circulation Research, 75, 181\u2013189.","journal-title":"Circulation Research"},{"key":"10175_CR127","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.03-0329fje","volume":"17","author":"YJ Jung","year":"2003","unstructured":"Jung, Y. J., Isaacs, J. S., Lee, S., Trepel, J., & Neckers, L. (2003). IL-1\u03b2 mediated up-regulation of HIF-l\u03b1 via an NFkB\/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. The FASEB Journal, 17, 1\u201322.","journal-title":"The FASEB Journal"},{"key":"10175_CR128","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s00018-023-04934-1","volume":"80","author":"B McDonald","year":"2023","unstructured":"McDonald, B., Barth, K., & Schmidt, M. H. (2023). The origin of brain malignancies at the blood\u2013brain barrier. Cellular and Molecular Life Sciences, 80, 282.","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10175_CR129","doi-asserted-by":"publisher","first-page":"1607225","DOI":"10.3389\/fimmu.2025.1607225","volume":"16","author":"X Gong","year":"2025","unstructured":"Gong, X., Wang, X., Jin, J., & Gong, Z. (2025). The novel functions of chemokines in lung cancer progression. Frontiers in Immunology, 16, 1607225.","journal-title":"Frontiers in Immunology"},{"key":"10175_CR130","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","volume":"51","author":"FR Greten","year":"2019","unstructured":"Greten, F. R., & Grivennikov, S. I. (2019). Inflammation and cancer: Triggers, mechanisms, and consequences. Immunity, 51, 27\u201341.","journal-title":"Immunity"},{"key":"10175_CR131","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008). Cancer-related inflammation. Nature, 454, 436\u2013444.","journal-title":"Nature"},{"key":"10175_CR132","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s12935-023-03080-9","volume":"23","author":"B Hassani","year":"2023","unstructured":"Hassani, B., Attar, Z., & Firouzabadi, N. (2023). The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: Foes versus allies. Cancer Cell International, 23, 254.","journal-title":"Cancer Cell International"},{"key":"10175_CR133","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1161\/CIRCULATIONAHA.118.033603","volume":"138","author":"E Bertero","year":"2018","unstructured":"Bertero, E., Canepa, M., Maack, C., & Ameri, P. (2018). Linking heart failure to cancer: Background evidence and research perspectives. Circulation, 138, 735\u2013742.","journal-title":"Circulation"},{"key":"10175_CR134","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10555-025-10241-x","volume":"44","author":"A Sattler","year":"2025","unstructured":"Sattler, A., Korzun, T., Gupta, K., Diba, P., Kyprianou, N., & Eksi, S. E. (2025). Sympathetic nerve signaling rewires the tumor microenvironment: A shift in microenvironmental-ity. Cancer and Metastasis Reviews, 44, 25.","journal-title":"Cancer and Metastasis Reviews"},{"key":"10175_CR135","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc3978","volume":"15","author":"SW Cole","year":"2015","unstructured":"Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K. (2015). Sympathetic nervous system regulation of the tumour microenvironment. Nature Reviews Cancer, 15, 563\u2013572.","journal-title":"Nature Reviews Cancer"},{"key":"10175_CR136","first-page":"55","volume":"6","author":"T Tani","year":"2024","unstructured":"Tani, T., Oikawa, M., Misaka, T., Ishida, T., & Takeishi, Y. (2024). Heart failure post-myocardial infarction promotes mammary tumor growth through the NGF-TRKA pathway. Cardio Oncology, 6, 55\u201366.","journal-title":"Cardio Oncology"},{"key":"10175_CR137","doi-asserted-by":"publisher","first-page":"8103","DOI":"10.3390\/curroncol29110640","volume":"29","author":"F Bruno","year":"2022","unstructured":"Bruno, F., Arcuri, D., Vozzo, F., Malvaso, A., Montesanto, A., & Maletta, R. (2022). Expression and signaling pathways of nerve growth factor (NGF) and pro-NGF in breast cancer: A systematic review. Current Oncology, 29, 8103\u20138120.","journal-title":"Current Oncology"},{"key":"10175_CR138","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1161\/CIRCULATIONAHA.117.030816","volume":"138","author":"WC Meijers","year":"2018","unstructured":"Meijers, W. C., Maglione, M., Bakker, S. J., Oberhuber, R., Kieneker, L. M., De Jong, S., Haubner, B. J., Nagengast, W. B., Lyon, A. R., & Van Der Vegt, B. (2018). Heart failure stimulates tumor growth by circulating factors. Circulation, 138, 678\u2013691.","journal-title":"Circulation"},{"key":"10175_CR139","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s12920-023-01763-w","volume":"16","author":"H Liu","year":"2023","unstructured":"Liu, H., Wu, X., Wang, D., Li, Q., Zhang, X., & Xu, L. (2023). Unveiling the role of miR-137-3p\/miR-296-5p\/SERPINA3 signaling in colorectal cancer progression: Integrative analysis of gene expression profiles and in vitro studies. BMC Medical Genomics, 16, 327.","journal-title":"BMC Medical Genomics"},{"key":"10175_CR140","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/biomedicines11010156","volume":"11","author":"M De Mezer","year":"2023","unstructured":"De Mezer, M., Rogali\u0144ski, J., Przewo\u017any, S., Chojnicki, M., Niepolski, L., Sobieska, M., & Przysta\u0144ska, A. (2023). SERPINA3: Stimulator or inhibitor of pathological changes. Biomedicines, 11, 156.","journal-title":"Biomedicines"},{"key":"10175_CR141","doi-asserted-by":"publisher","first-page":"6225","DOI":"10.3390\/jcm11206225","volume":"11","author":"S P\u0105czek","year":"2022","unstructured":"P\u0105czek, S., & Mroczko, B. (2022). The role of selected serpins in gastrointestinal (GI) malignancies. Journal of clinical medicine, 11, 6225.","journal-title":"Journal of clinical medicine"},{"key":"10175_CR142","doi-asserted-by":"publisher","first-page":"E7159","DOI":"10.1073\/pnas.1700455114","volume":"114","author":"YS Chang","year":"2017","unstructured":"Chang, Y. S., Jalgaonkar, S. P., Middleton, J. D., & Hai, T. (2017). Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis. Proceedings of the National Academy of Sciences, 114, E7159\u2013E7168.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10175_CR143","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1158\/0008-5472.CAN-21-2463","volume":"82","author":"L Awwad","year":"2022","unstructured":"Awwad, L., & Aronheim, A. (2022). Cardiac dysfunction promotes cancer progression via multiple secreted factors. Cancer research, 82, 1753\u20131761.","journal-title":"Cancer research"},{"key":"10175_CR144","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s13402-023-00907-5","volume":"47","author":"Y Liu","year":"2024","unstructured":"Liu, Y., Cao, Y., Liu, P., Zhai, S., Liu, Y., Tang, X., Lin, J., Shi, M., Qi, D., & Deng, X. (2024). ATF3-induced activation of NF-\u03baB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma. Cellular Oncology, 47, 939\u2013950.","journal-title":"Cellular Oncology"},{"key":"10175_CR145","doi-asserted-by":"publisher","first-page":"ehab724","DOI":"10.1093\/eurheartj\/ehab724.2841","volume":"42","author":"L Awwad","year":"2021","unstructured":"Awwad, L., & Aronheim, A. (2021). Irreversible cardiac remodeling promotes cancer progression via secreted factors in ATF3 transgenic mouse model. European Heart Journal, 42, ehab724.","journal-title":"European Heart Journal"},{"key":"10175_CR146","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1161\/CIRCULATIONAHA.123.066911","volume":"149","author":"T Caller","year":"2024","unstructured":"Caller, T., Rotem, I., Shaihov-Teper, O., Lendengolts, D., Schary, Y., Shai, R., Glick-Saar, E., Dominissini, D., Motiei, M., & Katzir, I. (2024). Small extracellular vesicles from infarcted and failing heart accelerate tumor growth. Circulation, 149, 1729\u20131748.","journal-title":"Circulation"},{"key":"10175_CR147","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41392-023-01336-4","volume":"8","author":"Y Yuan","year":"2023","unstructured":"Yuan, Y., Mei, Z., Qu, Z., Li, G., Yu, S., Liu, Y., Liu, K., Shen, Z., Pu, J., & Wang, Y. (2023). Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure. Signal Transduction and Targeted Therapy, 8, 121.","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10175_CR148","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.gene.2018.05.100","volume":"670","author":"W Zhao","year":"2018","unstructured":"Zhao, W., Sun, Q., Yu, Z., Mao, S., Jin, Y., Li, J., Jiang, Z., Zhang, Y., Chen, M., & Chen, P. (2018). MiR-320a-3p\/ELF3 axis regulates cell metastasis and invasion in non-small cell lung cancer via PI3K\/Akt pathway. Gene, 670, 31\u201337.","journal-title":"Gene"},{"key":"10175_CR149","doi-asserted-by":"publisher","first-page":"9664","DOI":"10.3892\/mmr.2017.7819","volume":"16","author":"X Ge","year":"2017","unstructured":"Ge, X., Cui, H., Zhou, Y., Yin, D., Feng, Y., Xin, Q., Xu, X., Liu, W., Liu, S., & Zhang, Q. (2017). miR-320a modulates cell growth and chemosensitivity via regulating ADAM10 in gastric cancer. Molecular Medicine Reports, 16, 9664\u20139670.","journal-title":"Molecular Medicine Reports"},{"key":"10175_CR150","doi-asserted-by":"crossref","unstructured":"Dang, Y., Ma, M., Wang, Y., Zhao, M., Cao, Y., Su, H., Liu, T., Zheng, M., Gao, J., & Wu, X. (2025). Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity. Cell Reports 44.","DOI":"10.1016\/j.celrep.2025.115572"},{"key":"10175_CR151","doi-asserted-by":"publisher","first-page":"68314","DOI":"10.18632\/oncotarget.11599","volume":"7","author":"C Zhou","year":"2016","unstructured":"Zhou, C., Chen, X., Zeng, W., Peng, C., Huang, G., Li, X., Ouyang, Z., Luo, Y., Xu, X., & Xu, B. (2016). Propranolol induced G0\/G1\/S phase arrest and apoptosis in melanoma cells via AKT\/MAPK pathway. Oncotarget, 7, 68314.","journal-title":"Oncotarget"},{"key":"10175_CR152","first-page":"884","volume":"11","author":"J Yang","year":"2021","unstructured":"Yang, J., Yang, X., Gao, L., Zhang, J., Yi, C., & Huang, Y. (2021). The role of the renin-angiotensin system inhibitors in malignancy: A review. American journal of cancer research, 11, 884.","journal-title":"American journal of cancer research"},{"key":"10175_CR153","doi-asserted-by":"publisher","first-page":"E4111","DOI":"10.1073\/pnas.1511698112","volume":"112","author":"C Scafoglio","year":"2015","unstructured":"Scafoglio, C., Hirayama, B. A., Kepe, V., Liu, J., Ghezzi, C., Satyamurthy, N., Moatamed, N. A., Huang, J., Koepsell, H., & Barrio, J. R. (2015). Functional expression of sodium-glucose transporters in cancer. Proceedings of the National Academy of Sciences, 112, E4111\u2013E4119.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10175_CR154","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.canlet.2021.07.035","volume":"519","author":"D Ren","year":"2021","unstructured":"Ren, D., Sun, Y., Zhang, D., Li, D., Liu, Z., Jin, X., & Wu, H. (2021). SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis. Cancer letters, 519, 277\u2013288.","journal-title":"Cancer letters"},{"key":"10175_CR155","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.3390\/cancers14102566","volume":"14","author":"S Nochaiwong","year":"2022","unstructured":"Nochaiwong, S., Chuamanochan, M., Ruengorn, C., Noppakun, K., Awiphan, R., Phosuya, C., Tovanabutra, N., Chiewchanvit, S., Sood, M. M., & Hutton, B. (2022). Use of thiazide diuretics and risk of all types of skin cancers: An updated systematic review and meta-analysis. Cancers, 14, 2566.","journal-title":"Cancers"},{"key":"10175_CR156","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1002\/pros.21401","volume":"71","author":"CC Chang","year":"2011","unstructured":"Chang, C. C., Ho, S. C., Chiu, H. F., & Yang, C. Y. (2011). Statins increase the risk of prostate cancer: A population-based case\u2013control study. The Prostate, 71, 1818\u20131824.","journal-title":"The Prostate"},{"key":"10175_CR157","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1074\/jbc.M111.246173","volume":"287","author":"SA Mir","year":"2012","unstructured":"Mir, S. A., Chatterjee, A., Mitra, A., Pathak, K., Mahata, S. K., & Sarkar, S. (2012). Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. Journal of Biological Chemistry, 287, 2666\u20132677.","journal-title":"Journal of Biological Chemistry"},{"key":"10175_CR158","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.cellsig.2018.01.015","volume":"44","author":"Z Wei","year":"2018","unstructured":"Wei, Z., Jiang, W., Wang, H., Li, H., Tang, B., Liu, B., Jiang, H., & Sun, X. (2018). The IL-6\/STAT3 pathway regulates adhesion molecules and cytoskeleton of endothelial cells in thromboangiitis obliterans. Cellular signalling, 44, 118\u2013126.","journal-title":"Cellular signalling"},{"key":"10175_CR159","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11886-018-1067-7","volume":"20","author":"SM Schumacher","year":"2018","unstructured":"Schumacher, S. M., & Naga Prasad, S. V. (2018). Tumor necrosis factor-\u03b1 in heart failure: An updated review. Current cardiology reports, 20, 117.","journal-title":"Current cardiology reports"},{"key":"10175_CR160","doi-asserted-by":"publisher","first-page":"e1600200","DOI":"10.1126\/sciadv.1600200","volume":"2","author":"RJ DeBerardinis","year":"2016","unstructured":"DeBerardinis, R. J., & Chandel, N. S. (2016). Fundamentals of cancer metabolism. Science Advances, 2, e1600200.","journal-title":"Science Advances"},{"key":"10175_CR161","first-page":"129","volume":"95","author":"P Ginckels","year":"2022","unstructured":"Ginckels, P., & Holvoet, P. (2022). Oxidative stress and inflammation in cardiovascular diseases and cancer: Role of non-coding RNAs. The Yale Journal of Biology and Medicine, 95, 129.","journal-title":"The Yale Journal of Biology and Medicine"},{"key":"10175_CR162","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/ncb3094","volume":"17","author":"MY Fong","year":"2015","unstructured":"Fong, M. Y., Zhou, W., Liu, L., Alontaga, A. Y., Chandra, M., Ashby, J., Chow, A., O\u2019Connor, S. T. F., Li, S., & Chin, A. R. (2015). Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nature Cell Biology, 17, 183\u2013194.","journal-title":"Nature Cell Biology"},{"key":"10175_CR163","doi-asserted-by":"publisher","first-page":"11975","DOI":"10.3390\/cimb46110711","volume":"46","author":"E Al Ageeli","year":"2024","unstructured":"Al Ageeli, E. (2024). Dual roles of microRNA-122 in hepatocellular carcinoma and breast cancer progression and metastasis: A comprehensive review. Current Issues in Molecular Biology, 46, 11975\u201311992.","journal-title":"Current Issues in Molecular Biology"},{"key":"10175_CR164","doi-asserted-by":"publisher","first-page":"e17493","DOI":"10.1002\/advs.202417493","volume":"12","author":"Z Mei","year":"2025","unstructured":"Mei, Z., Liu, Q., Liu, G., Zhang, M., Fang, J., He, X., He, X., Qin, Z., Liu, R., & Liu, C. (2025). Tumor extracellular vesicles aggravate mitochondrial damage in myocardial ischemia\/reperfusion injury. Advanced Science, 12, e17493.","journal-title":"Advanced Science"},{"key":"10175_CR165","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40959-024-00207-3","volume":"10","author":"S Mori","year":"2024","unstructured":"Mori, S., Bertamino, M., Guerisoli, L., Stratoti, S., Canale, C., Spallarossa, P., Porto, I., & Ameri, P. (2024). Pericardial effusion in oncological patients: Current knowledge and principles of management. Cardio-Oncology, 10, 8.","journal-title":"Cardio-Oncology"},{"key":"10175_CR166","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3390\/ijms25010046","volume":"25","author":"MC Scott","year":"2023","unstructured":"Scott, M. C., & Fuller, S. (2023). The effects of intermittent cold exposure on adipose tissue. International Journal of Molecular Sciences, 25, 46.","journal-title":"International Journal of Molecular Sciences"},{"key":"10175_CR167","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1017\/S0007114515003177","volume":"114","author":"M Rodr\u00edguez-Monforte","year":"2015","unstructured":"Rodr\u00edguez-Monforte, M., Flores-Mateo, G., & S\u00e1nchez, E. (2015). Dietary patterns and CVD: A systematic review and meta-analysis of observational studies. British Journal of Nutrition, 114, 1341\u20131359.","journal-title":"British Journal of Nutrition"},{"key":"10175_CR168","doi-asserted-by":"crossref","unstructured":"Raymond-Lezman, J. R., Riskin, S. I., & Lezman, J. (2023). Benefits and risks of sun exposure to maintain adequate vitamin D levels. Cureus 15.","DOI":"10.7759\/cureus.38578"},{"key":"10175_CR169","doi-asserted-by":"publisher","first-page":"18287","DOI":"10.1038\/s41598-023-44205-4","volume":"13","author":"A Marvanova","year":"2023","unstructured":"Marvanova, A., Kasik, P., Elsnicova, B., Tibenska, V., Galatik, F., Hornikova, D., Zvolska, V., Vebr, P., Vodicka, P., & Hejnova, L. (2023). Continuous short-term acclimation to moderate cold elicits cardioprotection in rats, and alters \u03b2-adrenergic signaling and immune status. Scientific Reports, 13, 18287.","journal-title":"Scientific Reports"},{"key":"10175_CR170","doi-asserted-by":"crossref","unstructured":"Tsibulnikov, S. Y., Maslov, L. N., Naryzhnaya, N. V., Ivanov, V. V., Bushov, Y. V., Voronkov, N. S., Jaggi, A. S., & Oeltgen, P. R. (2019). Impact of cold adaptation on cardiac tolerance to ischemia\/reperfusion. Role of glucocorticoid and thyroid hormones (Vol. 38). General Physiology & Biophysics.","DOI":"10.4149\/gpb_2019002"},{"key":"10175_CR171","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.ajcnut.2024.08.016","volume":"120","author":"CE Orsso","year":"2024","unstructured":"Orsso, C. E., Caretero, A., Poltronieri, T. S., Arends, J., de van der Schueren, M. A., Kiss, N., Laviano, A., & Prado, C. M. (2024). Effects of high-protein supplementation during cancer therapy: A systematic review and meta-analysis. The American Journal of Clinical Nutrition, 120, 1311\u20131324.","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10175_CR172","doi-asserted-by":"publisher","first-page":"5030","DOI":"10.3390\/nu15245030","volume":"15","author":"AM Dingemans","year":"2023","unstructured":"Dingemans, A. M., van Walree, N., Schramel, F., Soud, M. Y. E., Baltru\u0161kevi\u010dien\u0117, E., Lybaert, W., Veldhorst, M., van den Berg, C. A., & Kaasa, S. (2023). High protein oral nutritional supplements enable the majority of cancer patients to meet protein intake recommendations during systemic anti-cancer treatment: A randomised controlled parallel-group study. Nutrients, 15, 5030.","journal-title":"Nutrients"},{"key":"10175_CR173","first-page":"43","volume":"8","author":"P Howe","year":"1994","unstructured":"Howe, P., Lungershausen, Y., Cobiac, L., Dandy, G., & Nestel, P. (1994). Effect of sodium restriction and fish oil supplementation on BP and thrombotic risk factors in patients treated with ACE inhibitors. Journal of Human Hypertension, 8, 43\u201349.","journal-title":"Journal of Human Hypertension"},{"key":"10175_CR174","unstructured":"Yang, J., Wang, F., Wang, Z., & Wang, L. (2024). Systematic Assessment of Chinese Medicine Compounds for Mitigating AnthracyclineInduced Cardiotoxicity (p. 30). Alternative Therapies in Health & Medicine."},{"key":"10175_CR175","doi-asserted-by":"publisher","first-page":"867521","DOI":"10.3389\/fphar.2022.867521","volume":"13","author":"I Cheang","year":"2022","unstructured":"Cheang, I., Liao, S., Zhu, Q., Ni, G., Wei, C., Jia, Z., Wu, Y., & Li, X. (2022). Integrating evidence of the traditional Chinese medicine collateral disease theory in prevention and treatment of cardiovascular continuum. Frontiers in Pharmacology, 13, 867521.","journal-title":"Frontiers in Pharmacology"},{"key":"10175_CR176","first-page":"711","volume":"4","author":"I Cheang","year":"2024","unstructured":"Cheang, I., Chen, Z., Zhu, X., Wang, T., Chang, L., Gao, R., Jia, Z., & Li, X. (2024). Translational research and clinical application of traditional Chinese medicine in cardiovascular diseases. JACC: Asia, 4, 711\u2013720.","journal-title":"JACC: Asia"},{"key":"10175_CR177","doi-asserted-by":"publisher","first-page":"1126110","DOI":"10.3389\/fcvm.2023.1126110","volume":"10","author":"Y Rao","year":"2023","unstructured":"Rao, Y., Wang, Y., Lin, Z., Zhang, X., Ding, X., Yang, Y., Liu, Z., & Zhang, B. (2023). Comparative efficacy and pharmacological mechanism of Chinese patent medicines against anthracycline-induced cardiotoxicity: An integrated study of network meta-analysis and network pharmacology approach. Frontiers in Cardiovascular Medicine, 10, 1126110.","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"10175_CR178","doi-asserted-by":"publisher","first-page":"153473542311647","DOI":"10.1177\/15347354231164753","volume":"22","author":"C Li","year":"2023","unstructured":"Li, C., Zheng, Y., Niu, D., Zhu, R., Yan, X., Qu, H., & Zhang, Y. (2023). Effects of traditional Chinese medicine injections for anthracyclines-induced cardiotoxicity: An overview of systematic reviews and meta-analyses. Integrative Cancer Therapies, 22, 15347354231164753.","journal-title":"Integrative Cancer Therapies"},{"key":"10175_CR179","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1152\/japplphysiol.00511.2019","volume":"128","author":"V Tibensk\u00e1","year":"2020","unstructured":"Tibensk\u00e1, V., Benesova, A., Vebr, P., Lipt\u00e1kov\u00e1, A., Hejnov\u00e1, L., Elsnicov\u00e1, B., Drahota, Z., Hornikova, D., Galat\u00edk, F., & Kolar, D. (2020). Gradual cold acclimation induces cardioprotection without affecting \u03b2-adrenergic receptor-mediated adenylyl cyclase signaling. Journal of Applied Physiology, 128, 1023\u20131032.","journal-title":"Journal of Applied Physiology"},{"key":"10175_CR180","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","volume":"42","author":"N Meunier-McVey","year":"2021","unstructured":"Meunier-McVey, N. (2021). 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. The European Heart Journal, 42, 3599\u20133726.","journal-title":"The European Heart Journal"},{"key":"10175_CR181","doi-asserted-by":"crossref","unstructured":"Lyon, A. R., Lopez-Fernandez, T., Couch, L. S., Asteggiano, R., Aznar, M. C., Bergler-Klein, J., Boriani, G., Cardinale, D., Cordoba, R., & Cosyns, B. (2022). 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS) Developed by the task force on cardio-oncology of the European Society of Cardiology (ESC). European heart Journal, 43, 4229\u20134361.","DOI":"10.1093\/eurheartj\/ehac244"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10175-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-026-10175-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10175-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:05:45Z","timestamp":1789470345000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12012-026-10175-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":181,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10175"],"URL":"https:\/\/doi.org\/10.1007\/s12012-026-10175-y","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"assertion":[{"value":"1 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical Trial Number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"97"}}