{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:44:01Z","timestamp":1792147441003,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["202201-065"],"award-info":[{"award-number":["202201-065"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shandong Province","award":["ZR2020MH031"],"award-info":[{"award-number":["ZR2020MH031"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Toxicol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12012-026-10193-w","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:02:03Z","timestamp":1789797723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exposure to Polystyrene Nanoplastics Induces Ferroptosis-Associated Cardiac Injury: Cell-Based Evidence for Lysosome-Associated NLRX1 Loss and an NLRX1\u2013STING\u2013NCOA4 Response"],"prefix":"10.1007","volume":"26","author":[{"given":"Guangzhen","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-9001","authenticated-orcid":false,"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"issue":"8","key":"10193_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12081298","volume":"12","author":"H Lai","year":"2022","unstructured":"Lai, H., Liu, X., & Qu, M. (2022). Nanoplastics and human health: Hazard identification and biointerface. Nanomaterials, 12(8), Article 1298. https:\/\/doi.org\/10.3390\/nano12081298","journal-title":"Nanomaterials"},{"issue":"2","key":"10193_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/nano11020496","volume":"11","author":"MS Yee","year":"2021","unstructured":"Yee, M.S., Hii, L.W., Looi, C.K., Lim, W.M., Wong, S.F., Kok, Y.Y., Tan, B.K., Wong, C.Y., & Leong, C.O. (2021). Impact of microplastics and nanoplastics on human health. Nanomaterials (Basel, Switzerland), 11(2), Article 496. https:\/\/doi.org\/10.3390\/nano11020496","journal-title":"Nanomaterials (Basel, Switzerland)"},{"issue":"10","key":"10193_CR3","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1056\/NEJMoa2309822","volume":"390","author":"R Marfella","year":"2024","unstructured":"Marfella, R., Prattichizzo, F., Sardu, C., Fulgenzi, G., Graciotti, L., Spadoni, T., D'Onofrio, N., Scisciola, L., La Grotta, R., Frig\u00e9, C., Pellegrini, V., Municin\u00f2, M., Siniscalchi, M., Spinetti, F., Vigliotti, G., Vecchione, C., Carrizzo, A., Accarino, G., Squillante, A., Spaziano, G., Mirra, D., Esposito, R., Altieri, S., Falco, G., Fenti, A., Galoppo, S., Canzano, S., Sasso, F. C., Matacchione, G., Olivieri, F., Ferraraccio, F., Panarese, I., Paolisso, P., Barbato, E., Lubritto, C., Balestrieri, M. L., Mauro, C., Caballero, A. E., Rajagopalan, S., Ceriello, A., D'Agostino, B., Iovino, P., & Paolisso, G. (2024). Microplastics and nanoplastics in atheromas and cardiovascular events. New England Journal of Medicine, 390(10), 900\u2013910. https:\/\/doi.org\/10.1056\/NEJMoa2309822","journal-title":"New England Journal of Medicine"},{"issue":"11","key":"10193_CR4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.125.327073","volume":"138","author":"Y Pan","year":"2026","unstructured":"Pan, Y., Liu, L., Luo, J., Zhou, X., Wang, Y., Zheng, L., Yang, Y., Peng, Z., Li, J., Su, G., Xue, M., Hua, K., Chen, H., & Yang, X. (2026). Micro(nano)plastics in the development of myocardial fibrosis: From clinical detection to molecular mechanism. Circulation Research, 138(11), Article e327073. https:\/\/doi.org\/10.1161\/CIRCRESAHA.125.327073","journal-title":"Circulation Research"},{"key":"10193_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134823","volume":"474","author":"JZ Yang","year":"2024","unstructured":"Yang, J. Z., Zhang, K. K., Hsu, C., Miao, L., Chen, L. J., Liu, J. L., Li, J. H., Li, X. W., Zeng, J. H., Chen, L., Li, J. H., Xie, X. L., & Wang, Q. (2024). Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-\u03b21\/Smad3 pathways. Journal of Hazardous Materials, 474, Article 134823. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.134823","journal-title":"Journal of Hazardous Materials"},{"key":"10193_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117712","volume":"290","author":"Z Xiong","year":"2025","unstructured":"Xiong, Z., Kong, Q., Hua, J., Chen, Q., & Wang, D. (2025). Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice. Ecotoxicology and Environmental Safety, 290, Article 117712. https:\/\/doi.org\/10.1016\/j.ecoenv.2025.117712","journal-title":"Ecotoxicology and Environmental Safety"},{"issue":"1","key":"10193_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-023-00557-3","volume":"20","author":"T Zhang","year":"2023","unstructured":"Zhang, T., Yang, S., Ge, Y., Wan, X., Zhu, Y., Yang, F., Li, J., Gong, S., Cheng, Y., Hu, C., Chen, Z., Yin, L., Pu, Y., & Liang, G. (2023). Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics. Particle and Fibre Toxicology, 20(1), Article 46. https:\/\/doi.org\/10.1186\/s12989-023-00557-3","journal-title":"Particle and Fibre Toxicology"},{"issue":"1","key":"10193_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02375-x","volume":"22","author":"K Wang","year":"2024","unstructured":"Wang, K., Du, Y., Li, P., Guan, C., Zhou, M., Wu, L., Liu, Z., & Huang, Z. (2024). Nanoplastics causes heart aging\/myocardial cell senescence through the Ca2+\/mtDNA\/cGAS-STING signaling cascade. Journal of Nanobiotechnology, 22(1), Article 96. https:\/\/doi.org\/10.1186\/s12951-024-02375-x","journal-title":"Journal of Nanobiotechnology"},{"issue":"45","key":"10193_CR9","doi-asserted-by":"publisher","first-page":"31569","DOI":"10.1021\/acsnano.4c13262","volume":"18","author":"T Zhang","year":"2024","unstructured":"Zhang, T., Yang, S., Ge, Y., Wan, X., Zhu, Y., Yang, F., Li, J., Gong, S., Cheng, Y., Hu, C., Chen, Z., Yin, L., Pu, Y., & Liang, G. (2024). Unveiling the heart\u2019s hidden enemy: Dynamic insights into polystyrene nanoplastic-induced cardiotoxicity based on cardiac organoid-on-a-chip. ACS Nano, 18(45), 31569\u201331585. https:\/\/doi.org\/10.1021\/acsnano.4c13262","journal-title":"ACS Nano"},{"key":"10193_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2025.115489","volume":"202","author":"J Ma","year":"2025","unstructured":"Ma, J., Ladd, D. M., Kaval, N., & Wang, H.-S. (2025). Toxicity of long term exposure to low dose polystyrene microplastics and nanoplastics in human iPSC-derived cardiomyocytes. Food and Chemical Toxicology, 202, Article 115489. https:\/\/doi.org\/10.1016\/j.fct.2025.115489","journal-title":"Food and Chemical Toxicology"},{"issue":"1","key":"10193_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09853-w","volume":"40","author":"W Fang","year":"2024","unstructured":"Fang, W., Xie, S., & Deng, W. (2024). Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future. Cell Biology and Toxicology, 40(1), Article Article 17. https:\/\/doi.org\/10.1007\/s10565-024-09853-w","journal-title":"Cell Biology and Toxicology"},{"issue":"4","key":"10193_CR12","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang, X., Stockwell, B. R., & Conrad, M. (2021). Ferroptosis: Mechanisms, biology and role in disease. Nature Reviews Molecular Cell Biology, 22(4), 266\u2013282. https:\/\/doi.org\/10.1038\/s41580-020-00324-8","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"6","key":"10193_CR13","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","volume":"25","author":"SJ Dixon","year":"2024","unstructured":"Dixon, S. J., & Olzmann, J. A. (2024). The cell biology of ferroptosis. Nature Reviews Molecular Cell Biology, 25(6), 424\u2013442. https:\/\/doi.org\/10.1038\/s41580-024-00703-5","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10193_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2025.126685","volume":"382","author":"H Niu","year":"2025","unstructured":"Niu, H., & Li, W. (2025). Exposure of polystyrene nanoplastics led to ferroptosis on cardiomyocytes. Environmental Pollution, 382, Article 126685. https:\/\/doi.org\/10.1016\/j.envpol.2025.126685","journal-title":"Environmental Pollution"},{"key":"10193_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101328","volume":"28","author":"G Miotto","year":"2020","unstructured":"Miotto, G., Rossetto, M., Di Paolo, M. L., Orian, L., Venerando, R., Roveri, A., Vu\u010dkovi\u0107, A. M., Bosello Travain, V., Zaccarin, M., Zennaro, L., Maiorino, M., Toppo, S., Ursini, F., & Cozza, G. (2020). Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biology, 28, Article 101328. https:\/\/doi.org\/10.1016\/j.redox.2019.101328","journal-title":"Redox Biology"},{"issue":"9","key":"10193_CR16","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","volume":"21","author":"KP Hopfner","year":"2020","unstructured":"Hopfner, K. P., & Hornung, V. (2020). Molecular mechanisms and cellular functions of cGAS-STING signalling. Nature Reviews Molecular Cell Biology, 21(9), 501\u2013521. https:\/\/doi.org\/10.1038\/s41580-020-0244-x","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"9","key":"10193_CR17","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","volume":"21","author":"A Decout","year":"2021","unstructured":"Decout, A., Katz, J. D., Venkatraman, S., & Ablasser, A. (2021). The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nature Reviews Immunology, 21(9), 548\u2013569. https:\/\/doi.org\/10.1038\/s41577-021-00524-z","journal-title":"Nature Reviews Immunology"},{"issue":"3","key":"10193_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166997","volume":"1870","author":"L Wang","year":"2024","unstructured":"Wang, L., Zhang, S., Liu, H., Gao, L., He, L., Chen, Y., Zhang, J., Yang, M., & He, C. (2024). STING activation in cardiomyocytes drives hypertrophy-associated heart failure via NF-\u03baB-mediated inflammatory response. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870(3), Article 166997. https:\/\/doi.org\/10.1016\/j.bbadis.2023.166997","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"11","key":"10193_CR19","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1161\/CIRCRESAHA.122.321587","volume":"132","author":"W Luo","year":"2023","unstructured":"Luo, W., Zou, X., Wang, Y., Dong, Z., Weng, X., Pei, Z., Song, S., Zhao, Y., Wei, Z., Gao, R., Zhang, B., Liu, L., Bai, P., Liu, J., Wang, X., Gao, T., Zhang, Y., Sun, X., Chen, H., Hu, K., Du, S., Sun, A., & Ge, J. (2023). Critical role of the cGAS-STING pathway in doxorubicin-induced cardiotoxicity. Circulation Research, 132(11), e223\u2013e242. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.321587","journal-title":"Circulation Research"},{"issue":"4\u20136","key":"10193_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1089\/ars.2023.0510","volume":"42","author":"Q Chen","year":"2025","unstructured":"Chen, Q., Wang, Y., Wang, J., Ouyang, X., Zhong, J., Huang, Y., Huang, Z., Zheng, B., Peng, L., Tang, X., & Li, S. (2025). Lipotoxicity induces cardiomyocyte ferroptosis via activating the STING pathway. Antioxidants & Redox Signaling, 42(4\u20136), 184\u2013198. https:\/\/doi.org\/10.1089\/ars.2023.0510","journal-title":"Antioxidants &amp; Redox Signaling"},{"issue":"1","key":"10193_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02216-9","volume":"10","author":"X Wang","year":"2025","unstructured":"Wang, X., Chen, T., Chen, S., Zhang, J., Cai, L., Liu, C., Zhang, Y., Wu, X., Li, N., Ma, Z., Cao, L., Li, Q., Guo, C., Deng, Q., Qi, W., Hou, Y., Ren, R., Sui, W., Zheng, H., Zhang, Y., Zhang, M., & Zhang, C. (2025). STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation. Signal Transduction and Targeted Therapy, 10(1), Article Article 136. https:\/\/doi.org\/10.1038\/s41392-025-02216-9","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"1","key":"10193_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2023.100635","volume":"47","author":"PY Bi","year":"2024","unstructured":"Bi, P. Y., Killackey, S. A., Schweizer, L., & Girardin, S. E. (2024). NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy. Biomedical Journal, 47(1), Article 100635. https:\/\/doi.org\/10.1016\/j.bj.2023.100635","journal-title":"Biomedical Journal"},{"key":"10193_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.852243","volume":"15","author":"LE Fritsch","year":"2022","unstructured":"Fritsch, L. E., Ju, J., Gudenschwager Basso, E. K., Soliman, E., Paul, S., Chen, J., Kaloss, A. M., Kowalski, E. A., Tuhy, T. C., Somaiya, R. D., Wang, X., Allen, I. C., Theus, M. H., & Pickrell, A. M. (2022). Type I interferon response is mediated by NLRX1-cGAS-STING signaling in brain injury. Frontiers in Molecular Neuroscience, 15, Article Article 852243. https:\/\/doi.org\/10.3389\/fnmol.2022.852243","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"8","key":"10193_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2024.119852","volume":"1871","author":"K Mi","year":"2024","unstructured":"Mi, K., Wang, X., Ma, C., Tan, Y., Zhao, G., Cao, X., & Yuan, H. (2024). NLRX1 attenuates endoplasmic reticulum stress via STING in cardiac hypertrophy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1871(8), Article Article 119852. https:\/\/doi.org\/10.1016\/j.bbamcr.2024.119852","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"10193_CR25","doi-asserted-by":"publisher","first-page":"pp. 41","DOI":"10.1007\/978-3-030-62026-4_4","volume-title":"Ferroptosis: Mechanism and diseases","author":"N Santana-Codina","year":"2021","unstructured":"Santana-Codina, N., Gikandi, A., & Mancias, J. D. (2021). The role of NCOA4-mediated ferritinophagy in ferroptosis. In A. F. Florez & H. Alborzinia (Eds.), Ferroptosis: Mechanism and diseases (Vol. Vol. 1301, pp. 41\u201357). Springer. https:\/\/doi.org\/10.1007\/978-3-030-62026-4_4"},{"issue":"6","key":"10193_CR26","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","volume":"7","author":"Y Fang","year":"2021","unstructured":"Fang, Y., Chen, X., Tan, Q., Zhou, H., Xu, J., & Gu, Q. (2021). Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: A new mechanism of action. ACS Central Science, 7(6), 980\u2013989. https:\/\/doi.org\/10.1021\/acscentsci.0c01592","journal-title":"ACS Central Science"},{"issue":"2","key":"10193_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118913","volume":"1868","author":"M Gryzik","year":"2021","unstructured":"Gryzik, M., Asperti, M., Denardo, A., Arosio, P., & Poli, M. (2021). NCOA4-mediated ferritinophagy promotes ferroptosis induced by erastin, but not by RSL3 in HeLa cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1868(2), Article 118913. https:\/\/doi.org\/10.1016\/j.bbamcr.2020.118913","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"issue":"7","key":"10193_CR28","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13621","volume":"57","author":"JY Li","year":"2024","unstructured":"Li, J. Y., Feng, Y. H., Li, Y. X., He, P. Y., Zhou, Q. Y., Tian, Y. P., Yao, R. Q., & Yao, Y. M. (2024). Ferritinophagy: A novel insight into the double-edged sword in ferritinophagy-ferroptosis axis and human diseases. Cell Proliferation, 57(7), Article e13621. https:\/\/doi.org\/10.1111\/cpr.13621","journal-title":"Cell Proliferation"},{"issue":"7","key":"10193_CR29","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/s41419-022-05115-x","volume":"13","author":"J Wu","year":"2022","unstructured":"Wu, J., Liu, Q., Zhang, X., Tan, M., Li, X., Liu, P., Wu, L., Jiao, F., Lin, Z., Wu, X., Wang, X., Zhao, Y., & Ren, J. (2022). The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death & Disease, 13(7), 653. https:\/\/doi.org\/10.1038\/s41419-022-05115-x","journal-title":"Cell Death &amp; Disease"},{"key":"10193_CR30","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2023.08.025","volume":"208","author":"L Jin","year":"2023","unstructured":"Jin, L., Yu, B., Wang, H., Shi, L., Yang, J., Wu, L., Gao, C., Pan, H., Han, F., Lin, W., Lai, E. Y., Wang, Y. F., & Yang, Y. (2023). STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. Free Radical Biology and Medicine, 208, 348\u2013360. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2023.08.025","journal-title":"Free Radical Biology and Medicine"},{"key":"10193_CR31","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.2147\/IJN.S466258","volume":"19","author":"B Du","year":"2024","unstructured":"Du, B., Li, T., He, H., Xu, X., Zhang, C., Lu, X., Wang, Y., Cao, J., Lu, Y., Liu, Y., Hu, S., Li, J., Li, L., & Shi, M. (2024). Analysis of biodistribution and in vivo toxicity of varying sized polystyrene micro and nanoplastics in mice. International Journal of Nanomedicine, 19, 7617\u20137630. https:\/\/doi.org\/10.2147\/IJN.S466258","journal-title":"International Journal of Nanomedicine"},{"key":"10193_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.171681","volume":"924","author":"YMM Paing","year":"2024","unstructured":"Paing, Y. M. M., Eom, Y., Song, G. B., Kim, B., Choi, M. G., Hong, S., & Lee, S. H. (2024). Neurotoxic effects of polystyrene nanoplastics on memory and microglial activation: Insights from in vivo and in vitro studies. Science of the Total Environment, 924, Article 171681. https:\/\/doi.org\/10.1016\/j.scitotenv.2024.171681","journal-title":"Science of the Total Environment"},{"issue":"1","key":"10193_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/toxics14010052","volume":"14","author":"S Wang","year":"2026","unstructured":"Wang, S., Wu, T., Dai, J., Liu, X., He, L., Dong, Y., Zhao, L., & Li, N. (2025). Evaluation of polystyrene nanoplastics induced cardiotoxicity under different dietary patterns in mice. Toxics, 14(1), Article 52. https:\/\/doi.org\/10.3390\/toxics14010052","journal-title":"Toxics"},{"issue":"3","key":"10193_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031316","volume":"22","author":"T Fekete","year":"2021","unstructured":"Fekete, T., Bencze, D., B\u00edr\u00f3, E., Benk\u0151, S., & P\u00e1zm\u00e1ndi, K. (2021). Focusing on the cell type specific regulatory actions of NLRX1. International Journal of Molecular Sciences, 22(3), Article 1316. https:\/\/doi.org\/10.3390\/ijms22031316","journal-title":"International Journal of Molecular Sciences"},{"issue":"12","key":"10193_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260803","volume":"16","author":"A Banerjee","year":"2021","unstructured":"Banerjee, A., Billey, L. O., & Shelver, W. L. (2021). Uptake and toxicity of polystyrene micro\/nanoplastics in gastric cells: Effects of particle size and surface functionalization. PLoS One, 16(12), Article e0260803. https:\/\/doi.org\/10.1371\/journal.pone.0260803","journal-title":"PLoS One"},{"issue":"1","key":"10193_CR36","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/toxsci\/kfad023","volume":"193","author":"E El Hayek","year":"2023","unstructured":"El Hayek, E., Castillo, E., In, J. G., Garcia, M., Cerrato, J., Brearley, A., Gonzalez-Estrella, J., Herbert, G., Bleske, B., Benavidez, A., Hsiao, H., Yin, L., Campen, M. J., & Yu, X. (2023). Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity. Toxicological Sciences, 193(1), 90\u2013102. https:\/\/doi.org\/10.1093\/toxsci\/kfad023","journal-title":"Toxicological Sciences"}],"container-title":["Cardiovascular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10193-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-026-10193-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12012-026-10193-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:46:18Z","timestamp":1792143978000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12012-026-10193-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10193"],"URL":"https:\/\/doi.org\/10.1007\/s12012-026-10193-w","relation":{},"ISSN":["1530-7905","1559-0259"],"issn-type":[{"value":"1530-7905","type":"print"},{"value":"1559-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]},"assertion":[{"value":"28 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were performed in accordance with institutional guidelines and were approved by the Animal Ethics Committee of Shandong Provincial Hospital Affiliated with Shandong First Medical University (approval No. 2026-031). The approved protocol covered both the adult-mouse exposure experiment and isolation of primary cardiomyocytes from neonatal mice.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors reviewed the final version of the manuscript and consented to publication.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"112"}}