{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:46:41Z","timestamp":1791218801095,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,4,16]],"date-time":"2011-04-16T00:00:00Z","timestamp":1302912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1007\/s12013-011-9191-7","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T08:55:12Z","timestamp":1302857712000},"page":"251-259","source":"Crossref","is-referenced-by-count":22,"title":["Conformational Changes of the Multispecific Transporter Organic Anion Transporter 1 (OAT1\/SLC22A6) Suggests a Molecular Mechanism for Initial Stages of Drug and Metabolite Transport"],"prefix":"10.1007","volume":"61","author":[{"given":"Igor F.","family":"Tsigelny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Kovalskyy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina L.","family":"Kouznetsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksii","family":"Balinskyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Sharikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K.","family":"Nigam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,16]]},"reference":[{"key":"9191_CR1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/09687680410001716862","volume":"21","author":"J Abramson","year":"2004","unstructured":"Abramson, J., Iwata, S., & Kaback, H. R. (2004). Lactose permease as a paradigm for membrane transport proteins (review). Molecular Membrane Biology, 21, 227\u2013236.","journal-title":"Molecular Membrane Biology"},{"key":"9191_CR2","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1126\/science.1088196","volume":"301","author":"J Abramson","year":"2003","unstructured":"Abramson, J., Smirnova, I., Kasho, V., Verner, G., Kaback, H. R., & Iwata, S. (2003). Structure and mechanism of the lactose permease of Escherichia coli. Science, 301, 610\u2013615.","journal-title":"Science"},{"key":"9191_CR3","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1021\/bi010138+","volume":"40","author":"M Auer","year":"2001","unstructured":"Auer, M., Kim, M. J., Lemieux, M. J., Villa, A., Song, J., Li, X. D., et al. (2001). High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter. Biochemistry, 40, 6628\u20136635.","journal-title":"Biochemistry"},{"key":"9191_CR4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2958.1987.tb01931.x","volume":"1","author":"K Eiglmeier","year":"1987","unstructured":"Eiglmeier, K., Boos, W., & Cole, S. T. (1987). Nucleotide sequence and transcriptional startpoint of the GlpT gene of Escherichia coli: Extensive sequence homology of the glycerol-3-phosphate transport protein with components of the hexose-6-phosphate transport system. Molecular Microbiology, 1, 251\u2013258.","journal-title":"Molecular Microbiology"},{"key":"9191_CR5","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1016\/S0021-9258(18)93858-5","volume":"239","author":"S Hayashi","year":"1964","unstructured":"Hayashi, S., Koch, J. P., & Lin, E. C. (1964). Active transport of L-alpha-glycerophosphate in Escherichia coli. Journal of Biological Chemistry, 239, 3098\u20133105.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR6","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/0955-0674(93)90144-F","volume":"5","author":"PJ Henderson","year":"1993","unstructured":"Henderson, P. J. (1993). The 12-transmembrane helix transporters. Current Opinion in Cell Biology, 5, 708\u2013721.","journal-title":"Current Opinion in Cell Biology"},{"key":"9191_CR7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1126\/science.1087619","volume":"301","author":"Y Huang","year":"2003","unstructured":"Huang, Y., Lemieux, M. J., Song, J., Auer, M., & Wang, D. N. (2003). Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science, 301, 616\u2013620.","journal-title":"Science"},{"key":"9191_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.62.1.1-34.1998","volume":"62","author":"SS Pao","year":"1998","unstructured":"Pao, S. S., Paulsen, I. T., & Saier, M. H., Jr. (1998). Major facilitator superfamily. Microbiology and Molecular Biology Reviews, 62, 1\u201334.","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"9191_CR9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/pro.5560020103","volume":"2","author":"J Reizer","year":"1993","unstructured":"Reizer, J., Finley, K., Kakuda, D., MacLeod, C. L., Reizer, A., & Saier, M. H., Jr. (1993). Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Protein Science, 2, 20\u201330.","journal-title":"Protein Science"},{"key":"9191_CR10","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1074\/jbc.272.10.6471","volume":"272","author":"CE Lopez-Nieto","year":"1997","unstructured":"Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., & Nigam, S. K. (1997). Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. Journal of Biological Chemistry, 272, 6471\u20136478.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR11","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0022-3565(24)38273-4","volume":"289","author":"M Tsuda","year":"1999","unstructured":"Tsuda, M., Sekine, T., Takeda, M., Cha, S. H., Kanai, Y., Kimura, M., et al. (1999). Transport of ochratoxin A by renal multispecific organic anion transporter 1. Journal of Pharmacology and Experimental Therapeutics, 289, 1301\u20131305.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"9191_CR12","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1523-1755.2005.00585.x","volume":"68","author":"RK Zalups","year":"2005","unstructured":"Zalups, R. K., & Ahmad, S. (2005). Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1. Kidney International, 68, 1684\u20131699.","journal-title":"Kidney International"},{"key":"9191_CR13","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1074\/jbc.M508050200","volume":"281","author":"SA Eraly","year":"2006","unstructured":"Eraly, S. A., Vallon, V., Vaughn, D. A., Gangoiti, J. A., Richter, K., Nagle, M., et al. (2006). Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. Journal of Biological Chemistry, 281, 5072\u20135083.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR14","doi-asserted-by":"crossref","first-page":"F867","DOI":"10.1152\/ajprenal.00528.2007","volume":"294","author":"V Vallon","year":"2008","unstructured":"Vallon, V., Rieg, T., Ahn, S. Y., Wu, W., Eraly, S. A., & Nigam, S. K. (2008). Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. American Journal of Physiology - Renal Physiology, 294, F867\u2013F873.","journal-title":"American Journal of Physiology - Renal Physiology"},{"key":"9191_CR15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00204-009-0445-8","volume":"83","author":"G Di Giusto","year":"2009","unstructured":"Di Giusto, G., Anzai, N., Ruiz, M. L., Endou, H., & Torres, A. M. (2009). Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride. Archives of Toxicology, 83, 887\u2013897.","journal-title":"Archives of Toxicology"},{"key":"9191_CR16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.taap.2004.10.016","volume":"204","author":"DH Sweet","year":"2005","unstructured":"Sweet, D. H. (2005). Organic anion transporter (Slc22a) family members as mediators of toxicity. Toxicology and Applied Pharmacology, 204, 198\u2013215.","journal-title":"Toxicology and Applied Pharmacology"},{"key":"9191_CR17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-3565(24)37757-2","volume":"287","author":"C Sauvant","year":"1998","unstructured":"Sauvant, C., Silbernagl, S., & Gekle, M. (1998). Exposure to ochratoxin A impairs organic anion transport in proximal-tubule-derived opossum kidney cells. Journal of Pharmacology and Experimental Therapeutics, 287, 13\u201320.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"9191_CR18","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1016\/S0024-3205(01)01296-6","volume":"69","author":"KY Jung","year":"2001","unstructured":"Jung, K. Y., Takeda, M., Kim, D. K., Tojo, A., Narikawa, S., Yoo, B. S., et al. (2001). Characterization of ochratoxin A transport by human organic anion transporters. Life Sciences, 69, 2123\u20132135.","journal-title":"Life Sciences"},{"key":"9191_CR19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10254-002-0003-8","volume":"146","author":"BC Burckhardt","year":"2003","unstructured":"Burckhardt, B. C., & Burckhardt, G. (2003). Transport of organic anions across the basolateral membrane of proximal tubule cells. Reviews of Physiology Biochemistry and Pharmacology, 146, 95\u2013158.","journal-title":"Reviews of Physiology Biochemistry and Pharmacology"},{"key":"9191_CR20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.taap.2009.06.008","volume":"239","author":"V Zlender","year":"2009","unstructured":"Zlender, V., Breljak, D., Ljubojevic, M., Flajs, D., Balen, D., Brzica, H., et al. (2009). Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex. Toxicology and Applied Pharmacology, 239, 284\u2013296.","journal-title":"Toxicology and Applied Pharmacology"},{"issue":"286","key":"9191_CR21","first-page":"243","volume":"2010","author":"MA Nagle","year":"2010","unstructured":"Nagle, M. A., Truong, D. M., Dnyanmote, A. V., Eraly, S. A., Wu, W., & Nigam, S. K. (2010). Analysis of 3-dimensional systems for developing and mature kidney clarifies the role of OAT1 and OAT3 in antiviral handling. Journal of Biological Chemistry, 2010(286), 243\u2013251.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR22","doi-asserted-by":"crossref","first-page":"8654","DOI":"10.1074\/jbc.M708615200","volume":"283","author":"DM Truong","year":"2008","unstructured":"Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P. W., & Nigam, S. K. (2008). Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. Journal of Biological Chemistry, 283, 8654\u20138663.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR23","doi-asserted-by":"crossref","first-page":"18999","DOI":"10.1073\/pnas.0709387104","volume":"104","author":"YJ Chen","year":"2007","unstructured":"Chen, Y. J., Pornillos, O., Lieu, S., Ma, C., Chen, A. P., & Chang, G. (2007). X-ray structure of EmrE supports dual topology model. Proceedings of the National Academy of Sciences of the United States of America, 104, 18999\u201319004.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9191_CR24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/09687680701496507","volume":"24","author":"MJ Lemieux","year":"2007","unstructured":"Lemieux, M. J. (2007). Eukaryotic major facilitator superfamily transporter modeling based on the prokaryotic GlpT crystal structure. Molecular Membrane Biology, 24, 333\u2013341.","journal-title":"Molecular Membrane Biology"},{"key":"9191_CR25","doi-asserted-by":"crossref","first-page":"38071","DOI":"10.1074\/jbc.M608834200","volume":"281","author":"JL Perry","year":"2006","unstructured":"Perry, J. L., Dembla-Rajpal, N., Hall, L. A., & Pritchard, J. B. (2006). A three-dimensional model of human organic anion transporter 1: Aromatic amino acids required for substrate transport. Journal of Biological Chemistry, 281, 38071\u201338079.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR26","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1142\/S0219720008003801","volume":"6","author":"IF Tsigelny","year":"2008","unstructured":"Tsigelny, I. F., Greenberg, J., Kouznetsova, V., & Nigam, S. K. (2008). Modeling of glycerol-3-phosphate transporter suggests a potential \u2018tilt\u2019 mechanism involved in its function. Journal of Bioinformatics and Computational Biology, 6, 885\u2013904.","journal-title":"Journal of Bioinformatics and Computational Biology"},{"key":"9191_CR27","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/protein\/15.5.347","volume":"15","author":"I Tsigelny","year":"2002","unstructured":"Tsigelny, I., Sharikov, Y., & Ten Eyck, L. F. (2002). Hidden Markov models-based system (HMMSPECTR) for detecting structural homologies on the basis of sequential information. Protein Engineering, 15, 347\u2013352.","journal-title":"Protein Engineering"},{"key":"9191_CR28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01213011-200504000-00003","volume":"15","author":"T Fujita","year":"2005","unstructured":"Fujita, T., Brown, C., Carlson, E. J., Taylor, T., de la Cruz, M., Johns, S. J., et al. (2005). Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenetics and Genomics, 15, 201\u2013209.","journal-title":"Pharmacogenetics and Genomics"},{"issue":"33\u201338","key":"9191_CR29","first-page":"27","volume":"14","author":"W Humphrey","year":"1996","unstructured":"Humphrey, W., Dalke, A., & Schulten, K. (1996). VMD: Visual molecular dynamics. Journal of Molecular Graphics, 14(33\u201338), 27\u201338.","journal-title":"Journal of Molecular Graphics"},{"key":"9191_CR30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","volume":"4","author":"B Hess","year":"2008","unstructured":"Hess, B., Kutzner, C., Van Der Spoel, D., & Lindahl, E. (2008). GROMACS4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation. Journal of Chemical Theory and Computation, 4, 435\u2013447.","journal-title":"Journal of Chemical Theory and Computation"},{"key":"9191_CR31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00249-004-0448-6","volume":"34","author":"C Oostenbrink","year":"2005","unstructured":"Oostenbrink, C., Soares, T. A., van der Vegt, N. F., & van Gunsteren, W. F. (2005). Validation of the 53A6 GROMOS force field. European Biophysics Journal, 34, 273\u2013284.","journal-title":"European Biophysics Journal"},{"key":"9191_CR32","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/jcc.20090","volume":"25","author":"C Oostenbrink","year":"2004","unstructured":"Oostenbrink, C., Villa, A., Mark, A. E., & van Gunsteren, W. F. (2004). A biomolecular force field based on the free enthalpy of hydration and solvation: The GROMOS force-field parameter sets 53A5 and 53A6. Journal of Computational Chemistry, 25, 1656\u20131676.","journal-title":"Journal of Computational Chemistry"},{"key":"9191_CR33","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess, B., Bekker, H., Berendsen, H. J. C., & Fraaije, J. G. E. M. (1997). LINCS: A linear constraint solver for molecular simulations. Journal of Computational Chemistry, 18, 1463\u20131472.","journal-title":"Journal of Computational Chemistry"},{"key":"9191_CR34","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1093\/bioinformatics\/bti464","volume":"21","author":"CP Barrett","year":"2005","unstructured":"Barrett, C. P., & Noble, M. E. (2005). Dynamite extended: Two new services to simplify protein dynamic analysis. Bioinformatics, 21, 3174\u20133175.","journal-title":"Bioinformatics"},{"key":"9191_CR35","first-page":"F295","volume":"276","author":"R Lu","year":"1999","unstructured":"Lu, R., Chan, B. S., & Schuster, V. L. (1999). Cloning of the human kidney PAH transporter: Narrow substrate specificity and regulation by protein kinase C. American Journal of Physiology, 276, F295\u2013F303.","journal-title":"American Journal of Physiology"},{"key":"9191_CR36","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1006\/bbrc.1998.9978","volume":"255","author":"JE Race","year":"1999","unstructured":"Race, J. E., Grassl, S. M., Williams, W. J., & Holtzman, E. J. (1999). Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochemical and Biophysical Research Communications, 255, 508\u2013514.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9191_CR37","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nbt0796-857","volume":"14","author":"CE Lopez-Nieto","year":"1996","unstructured":"Lopez-Nieto, C. E., & Nigam, S. K. (1996). Selective amplification of protein-coding regions of large sets of genes using statistically designed primer sets. Nature Biotechnology, 14, 857\u2013861.","journal-title":"Nature Biotechnology"},{"key":"9191_CR38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00041552-200309000-00011","volume":"12","author":"SA Eraly","year":"2003","unstructured":"Eraly, S. A., Blantz, R. C., Bhatnagar, V., & Nigam, S. K. (2003). Novel aspects of renal organic anion transporters. Current Opinion in Nephrology and Hypertension, 12, 551\u2013558.","journal-title":"Current Opinion in Nephrology and Hypertension"},{"key":"9191_CR39","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1124\/mol.65.3.479","volume":"65","author":"SA Eraly","year":"2004","unstructured":"Eraly, S. A., Bush, K. T., Sampogna, R. V., Bhatnagar, V., & Nigam, S. K. (2004). The molecular pharmacology of organic anion transporters: From DNA to FDA? Molecular Pharmacology, 65, 479\u2013487.","journal-title":"Molecular Pharmacology"},{"key":"9191_CR40","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/med.10019","volume":"22","author":"G You","year":"2002","unstructured":"You, G. (2002). Structure, function, and regulation of renal organic anion transporters. Medicinal Research Reviews, 22, 602\u2013616.","journal-title":"Medicinal Research Reviews"},{"key":"9191_CR41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1389200043489207","volume":"5","author":"G You","year":"2004","unstructured":"You, G. (2004). The role of organic ion transporters in drug disposition: An update. Current Drug Metabolism, 5, 55\u201362.","journal-title":"Current Drug Metabolism"},{"key":"9191_CR42","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11095-006-9144-9","volume":"24","author":"F Zhou","year":"2007","unstructured":"Zhou, F., & You, G. (2007). Molecular insights into the structure\u2013function relationship of organic anion transporters OATs. Pharmaceutical Research, 24, 28\u201336.","journal-title":"Pharmaceutical Research"},{"key":"9191_CR43","doi-asserted-by":"crossref","first-page":"31422","DOI":"10.1074\/jbc.M109.024489","volume":"284","author":"SY Ahn","year":"2009","unstructured":"Ahn, S. Y., Eraly, S. A., Tsigelny, I., & Nigam, S. K. (2009). Interaction of organic cations with organic anion transporters. Journal of Biological Chemistry, 284, 31422\u201331430.","journal-title":"Journal of Biological Chemistry"},{"key":"9191_CR44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1124\/mol.109.056564","volume":"76","author":"SY Ahn","year":"2009","unstructured":"Ahn, S. Y., & Nigam, S. K. (2009). Toward a systems level understanding of organic anion and other multispecific drug transporters: A remote sensing and signaling hypothesis. Molecular Pharmacology, 76, 481\u2013490.","journal-title":"Molecular Pharmacology"},{"key":"9191_CR45","doi-asserted-by":"crossref","first-page":"23841","DOI":"10.1074\/jbc.M703467200","volume":"282","author":"G Kaler","year":"2007","unstructured":"Kaler, G., Truong, D. M., Khandelwal, A., Nagle, M., Eraly, S. A., Swaan, P. W., et al. (2007). Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. Journal of Biological Chemistry, 282, 23841\u201323853.","journal-title":"Journal of Biological Chemistry"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-011-9191-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-011-9191-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-011-9191-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T02:54:36Z","timestamp":1741143276000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-011-9191-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,16]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["9191"],"URL":"https:\/\/doi.org\/10.1007\/s12013-011-9191-7","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,16]]}}}