{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:47:42Z","timestamp":1744289262065},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T00:00:00Z","timestamp":1351555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s12013-012-9442-2","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T20:04:01Z","timestamp":1351541041000},"page":"381-398","source":"Crossref","is-referenced-by-count":10,"title":["Bumetanide Hyperpolarizes Madin\u2013Darby Canine Kidney Cells and Enhances Cellular Gentamicin Uptake by Elevating Cytosolic Ca2+ Thus Facilitating Intermediate Conductance Ca2+-Activated Potassium Channels"],"prefix":"10.1007","volume":"65","author":[{"given":"Tian","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-qin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Cai","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding-Hua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Steyger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Gen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,30]]},"reference":[{"key":"9442_CR1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/j.1552-4604.1981.tb05675.x","volume":"21","author":"RE Brummett","year":"1981","unstructured":"Brummett, R. E., Bendrick, T., & Himes, D. (1981). Comparative ototoxicity of bumetanide and furosemide when used in combination with kanamycin. Journal of Clinical Pharmacology, 21, 628\u2013636.","journal-title":"Journal of Clinical Pharmacology"},{"key":"9442_CR2","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","volume":"72","author":"LP Rybak","year":"2007","unstructured":"Rybak, L. P., & Ramkumar, V. (2007). Ototoxicity. Kidney International, 72, 931\u2013935.","journal-title":"Kidney International"},{"key":"9442_CR3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10162-007-0105-8","volume":"9","author":"RR Taylor","year":"2008","unstructured":"Taylor, R. R., Nevill, G., & Forge, A. (2008). Rapid hair cell loss: A mouse model for cochlear lesions. Journal of the Association for Research in Otolaryngology: JARO, 9, 44\u201364.","journal-title":"Journal of the Association for Research in Otolaryngology: JARO"},{"key":"9442_CR4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000276948","volume":"59","author":"H Naito","year":"1997","unstructured":"Naito, H., & Watanabe, K. (1997). Alteration in capillary permeability of horseradish peroxidase in the stria vascularis and movement of leaked horseradish peroxidase after administration of furosemide. ORL Journal of Oto-Rhino-Laryngology and Its Related Specialties, 59, 248\u2013257.","journal-title":"ORL Journal of Oto-Rhino-Laryngology and Its Related Specialties"},{"key":"9442_CR5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0030-6665(20)30770-2","volume":"26","author":"LP Rybak","year":"1993","unstructured":"Rybak, L. P. (1993). Ototoxicity of loop diuretics. Otolaryngologic Clinics of North America, 26, 829\u2013844.","journal-title":"Otolaryngologic Clinics of North America"},{"key":"9442_CR6","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1080\/003655402\/000028051","volume":"122","author":"H Azuma","year":"2002","unstructured":"Azuma, H., Takeuchi, S., Higashiyama, K., Ando, M., Kakigi, A., Nakahira, M., et al. (2002). Bumetanide-induced enlargement of the intercellular space in the stria vascularis requires an active Na+\u2013K+\u2013ATPase. Acta Oto-Laryngologica, 122, 816\u2013821.","journal-title":"Acta Oto-Laryngologica"},{"key":"9442_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5955(03)00226-0","volume":"186","author":"K Higashiyama","year":"2003","unstructured":"Higashiyama, K., Takeuchi, S., Azuma, H., Sawada, S., Yamakawa, K., Kakigi, A., et al. (2003). Bumetanide-induced enlargement of the intercellular space in the stria vascularis critically depends on Na+ transport. Hearing Research, 186, 1\u20139.","journal-title":"Hearing Research"},{"key":"9442_CR8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0005-2736(97)00225-3","volume":"1369","author":"F Gagnon","year":"1998","unstructured":"Gagnon, F., Orlov, S. N., Tremblay, J., & Hamet, P. (1998). Complete inhibition of Na+, K+, Cl\u2212 cotransport in Madin\u2013Darby canine kidney cells by PMA-sensitive protein kinase. Biochimica et Biophysica Acta, 1369, 233\u2013239.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"Suppl A","key":"9442_CR9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/13.suppl_A.9","volume":"13","author":"G Kahlmeter","year":"1984","unstructured":"Kahlmeter, G., & Dahlager, J. I. (1984). Aminoglycoside toxicity: A review of clinical studies published between 1975 and 1982. Journal of Antimicrobial Chemotherapy, 13(Suppl A), 9\u201322.","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"9442_CR10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1124\/mol.110.068130","volume":"79","author":"MG Leitner","year":"2011","unstructured":"Leitner, M. G., Halaszovich, C. R., & Oliver, D. (2011). Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate. Molecular Pharmacology, 79, 51\u201360.","journal-title":"Molecular Pharmacology"},{"key":"9442_CR11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000013861","volume":"5","author":"A Forge","year":"2000","unstructured":"Forge, A., & Schacht, J. (2000). Aminoglycoside antibiotics [in process citation]. Audiology and Neurotology, 5, 3\u201322.","journal-title":"Audiology and Neurotology"},{"key":"9442_CR12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1113\/jphysiol.2005.085951","volume":"567","author":"W Marcotti","year":"2005","unstructured":"Marcotti, W., van Netten, S. M., & Kros, C. J. (2005). The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels. The Journal of physiology, 567, 505\u2013521.","journal-title":"The Journal of physiology"},{"key":"9442_CR13","doi-asserted-by":"crossref","first-page":"e22347","DOI":"10.1371\/journal.pone.0022347","volume":"6","author":"A Alharazneh","year":"2011","unstructured":"Alharazneh, A., Luk, L., Huth, M., Monfared, A., Steyger, P., Cheng, A., et al. (2011). Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity. PLoS ONE, 6, e22347.","journal-title":"PLoS ONE"},{"key":"9442_CR14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(95)01198-6","volume":"704","author":"E Hashino","year":"1995","unstructured":"Hashino, E., & Shero, M. (1995). Endocytosis of aminoglycoside antibiotics in sensory hair cells. Brain Research, 704, 135\u2013140.","journal-title":"Brain Research"},{"key":"9442_CR15","doi-asserted-by":"crossref","first-page":"9939","DOI":"10.1523\/JNEUROSCI.1124-08.2008","volume":"28","author":"RJ Goodyear","year":"2008","unstructured":"Goodyear, R. J., Gale, J. E., Ranatunga, K. M., Kros, C. J., & Richardson, G. P. (2008). Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 28, 9939\u20139952.","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"9442_CR16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/srep00059","volume":"1","author":"H Li","year":"2011","unstructured":"Li, H., & Steyger, P. S. (2011). Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. Science Reports, 1, 59.","journal-title":"Science Reports"},{"key":"9442_CR17","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1172\/JCI112463","volume":"77","author":"P Tran Ba Huy","year":"1986","unstructured":"Tran Ba Huy, P., Bernard, P., & Schacht, J. (1986). Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs. Journal of Clinical Investigation, 77, 1492\u20131500.","journal-title":"Journal of Clinical Investigation"},{"key":"9442_CR18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0196-0709(86)80037-0","volume":"7","author":"DJ Lim","year":"1986","unstructured":"Lim, D. J. (1986). Effects of noise and ototoxic drugs at the cellular level in the cochlea: A review. American Journal of Otolaryngology, 7, 73\u201399.","journal-title":"American Journal of Otolaryngology"},{"key":"9442_CR19","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1523\/JNEUROSCI.23-10-04054.2003","volume":"23","author":"JR Meyers","year":"2003","unstructured":"Meyers, J. R., MacDonald, R. B., Duggan, A., Lenzi, D., Standaert, D. G., Corwin, J. T., et al. (2003). Lighting up the senses: Fm1-43 loading of sensory cells through nonselective ion channels. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 23, 4054\u20134065.","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"issue":"6","key":"9442_CR20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10162-011-0288-x","volume":"12","author":"RS Stepanyan","year":"2011","unstructured":"Stepanyan, R. S., Indzhykulian, A. A., Velez-Ortega, A. C., Boger, E. T., Steyger, P. S., Friedman, T. B., et al. (2011). Trpa1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells. Journal of the Association for Research in Otolaryngology: JARO, 12(6), 729\u2013740.","journal-title":"Journal of the Association for Research in Otolaryngology: JARO"},{"key":"9442_CR21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.heares.2005.02.002","volume":"204","author":"SE Myrdal","year":"2005","unstructured":"Myrdal, S. E., Johnson, K. C., & Steyger, P. S. (2005). Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis. Hearing Research, 204, 156\u2013169.","journal-title":"Hearing Research"},{"key":"9442_CR22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.heares.2005.02.005","volume":"204","author":"SE Myrdal","year":"2005","unstructured":"Myrdal, S. E., & Steyger, P. S. (2005). Trpv1 regulators mediate gentamicin penetration of cultured kidney cells. Hearing Research, 204, 170\u2013182.","journal-title":"Hearing Research"},{"issue":"Pt 17","key":"9442_CR23","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1242\/jcs.023705","volume":"121","author":"T Karasawa","year":"2008","unstructured":"Karasawa, T., Wang, Q., Fu, Y., Cohen, D. M., & Steyger, P. S. (2008). Trpv4 enhances the cellular uptake of aminoglycoside antibiotics. Journal of Cell Science, 121(Pt 17), 2871\u20132879.","journal-title":"Journal of Cell Science"},{"key":"9442_CR24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10162-009-0160-4","volume":"10","author":"Q Wang","year":"2009","unstructured":"Wang, Q., & Steyger, P. S. (2009). Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. Journal of the Association for Research in Otolaryngology: JARO, 10, 205\u2013219.","journal-title":"Journal of the Association for Research in Otolaryngology: JARO"},{"key":"9442_CR25","doi-asserted-by":"crossref","first-page":"C1187","DOI":"10.1152\/ajpcell.00024.2007","volume":"293","author":"F Lang","year":"2007","unstructured":"Lang, F., Vallon, V., Knipper, M., & Wangemann, P. (2007). Functional significance of channels and transporters expressed in the inner ear and kidney. American Journal of Physiology. Cell Physiology, 293, C1187\u2013C1208.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9442_CR26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/mol.108.053744","volume":"76","author":"E Migliati","year":"2009","unstructured":"Migliati, E., Meurice, N., DuBois, P., Fang, J. S., Somasekharan, S., Beckett, E., et al. (2009). Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site. Molecular Pharmacology, 76, 105\u2013112.","journal-title":"Molecular Pharmacology"},{"key":"9442_CR27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1681\/ASN.V92167","volume":"9","author":"R Sandoval","year":"1998","unstructured":"Sandoval, R., Leiser, J., & Molitoris, B. A. (1998). Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells. Journal of the American Society of Nephrology, 9, 167\u2013174.","journal-title":"Journal of the American Society of Nephrology"},{"key":"9442_CR28","doi-asserted-by":"crossref","first-page":"e19130","DOI":"10.1371\/journal.pone.0019130","volume":"6","author":"H Li","year":"2011","unstructured":"Li, H., Wang, Q., & Steyger, P. S. (2011). Acoustic trauma increases cochlear and hair cell uptake of gentamicin. PLoS ONE, 6, e19130.","journal-title":"PLoS ONE"},{"key":"9442_CR29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1113\/jphysiol.2001.012828","volume":"537","author":"Z-G Jiang","year":"2001","unstructured":"Jiang, Z. -G., Si, J. -Q., Lasarev, M. R., & Nuttall, A. L. (2001). Two resting potential levels regulated by inward rectifying potassium channels in guinea pig cochlea spiral modiolar artery. Journal of Physiology (London), 537, 829\u2013842.","journal-title":"Journal of Physiology (London)"},{"key":"9442_CR30","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/sj.bjp.0707244","volume":"151","author":"BC Guan","year":"2007","unstructured":"Guan, B. C., Si, J. Q., & Jiang, Z. G. (2007). Blockade of gap junction coupling by glycyrrhetinic acids in guinea pig cochlear artery: A whole-cell voltage- & current-clamp study. British Journal of Pharmacology, 151, 1049\u20131060.","journal-title":"British Journal of Pharmacology"},{"key":"9442_CR31","doi-asserted-by":"crossref","first-page":"H335","DOI":"10.1152\/ajpheart.00737.2010","volume":"300","author":"K-T Ma","year":"2011","unstructured":"Ma, K. -T., Guan, B. -C., Yang, Y. -Q., Nuttall, A. L., & Jiang, Z. -G. (2011). 2-Aminoethoxydiphenyl borate (2-apb) blocks electrical coupling and inhibits voltage-gated potassium channels in guinea-pig arteriole cells. American journal of physiology: Heart and circulatory physiology, 300, H335\u2013H346.","journal-title":"American journal of physiology: Heart and circulatory physiology"},{"key":"9442_CR32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0165-0270(94)90031-0","volume":"51","author":"PH Barry","year":"1994","unstructured":"Barry, P. H. (1994). JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements. Journal of Neuroscience Methods, 51, 107\u2013116.","journal-title":"Journal of Neuroscience Methods"},{"key":"9442_CR33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2170\/jjphysiol.44.433","volume":"44","author":"N Akaike","year":"1994","unstructured":"Akaike, N., & Harata, N. (1994). Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Japanese Journal of Physiology, 44, 433\u2013473.","journal-title":"Japanese Journal of Physiology"},{"key":"9442_CR34","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI0216112","volume":"110","author":"T Ma","year":"2002","unstructured":"Ma, T., Thiagarajah, J. R., Yang, H., Sonawane, N. D., Folli, C., Galietta, L. J., et al. (2002). Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. Journal of Clinical Investigation, 110, 1651\u20131658.","journal-title":"Journal of Clinical Investigation"},{"key":"9442_CR35","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF00580668","volume":"407","author":"F Lang","year":"1986","unstructured":"Lang, F., Defregger, M., & Paulmichl, M. (1986). Apparent chloride conductance of subconfluent Madin\u2013Darby canine kidney cells. Pflugers Archiv. European Journal of Physiology, 407, 158\u2013162.","journal-title":"Pflugers Archiv. European Journal of Physiology"},{"key":"9442_CR36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00232-002-1055-z","volume":"191","author":"HA Praetorius","year":"2003","unstructured":"Praetorius, H. A., Frokiaer, J., Nielsen, S., & Spring, K. R. (2003). Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells. The Journal of membrane biology, 191, 193\u2013200.","journal-title":"The Journal of membrane biology"},{"key":"9442_CR37","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ki.1992.291","volume":"42","author":"WL Macias","year":"1992","unstructured":"Macias, W. L., McAteer, J. A., Tanner, G. A., Fritz, A. L., & Armstrong, W. M. (1992). Nacl transport by Madin\u2013Darby canine kidney cyst epithelial cells. Kidney International, 42, 308\u2013319.","journal-title":"Kidney International"},{"key":"9442_CR38","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1124\/jpet.106.115212","volume":"320","author":"ZG Jiang","year":"2007","unstructured":"Jiang, Z. G., Shi, X., Guan, B. C., Zhao, H., & Yang, Y. Q. (2007). Dihydropyridines inhibit ach-induced hyperpolarization in cochlear artery via blockade of intermediate conductance calcium activated potassium channels. Journal of Pharmacology and Experimental Therapeutics, 320, 544\u2013551.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"9442_CR39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0005-2736(88)90182-4","volume":"941","author":"F Lang","year":"1988","unstructured":"Lang, F., Klotz, L., & Paulmichl, M. (1988). Effect of acetylcholine on electrical properties of subconfluent Madin\u2013Darby canine kidney cells. Biochimica et Biophysica Acta, 941, 217\u2013224.","journal-title":"Biochimica et Biophysica Acta"},{"key":"9442_CR40","doi-asserted-by":"crossref","first-page":"C102","DOI":"10.1152\/ajpcell.00354.2008","volume":"297","author":"B Fioretti","year":"2009","unstructured":"Fioretti, B., Catacuzzeno, L., Sforna, L., Aiello, F., Pagani, F., Ragozzino, D., et al. (2009). Histamine hyperpolarizes human glioblastoma cells by activating the intermediate-conductance Ca2+-activated K+ channel. American Journal of Physiology. Cell Physiology, 297, C102\u2013C110.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9442_CR41","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000107525","volume":"20","author":"R Garcia-Villegas","year":"2007","unstructured":"Garcia-Villegas, R., Escamilla, J., Fiorentino, R., & Cereijido, M. (2007). Potassium channels lost during harvesting of epithelial cells are restored with a kinetics that depends on channel species. Cellular Physiology and Biochemistry, 20, 405\u2013416.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"9442_CR42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/BF00594173","volume":"413","author":"M Paulmichl","year":"1989","unstructured":"Paulmichl, M., Friedrich, F., Maly, K., & Lang, F. (1989). The effect of hypoosmolarity on the electrical properties of Madin\u2013Darby canine kidney cells. Pflugers Archiv. European Journal of Physiology, 413, 456\u2013462.","journal-title":"Pflugers Archiv. European Journal of Physiology"},{"key":"9442_CR43","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1161\/01.ATV.0000156399.12787.5c","volume":"25","author":"I Grgic","year":"2005","unstructured":"Grgic, I., Eichler, I., Heinau, P., Si, H., Brakemeier, S., Hoyer, J., et al. (2005). Selective blockade of the intermediate-conductance Ca2+-activated K+ channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 25, 704\u2013709.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9442_CR44","doi-asserted-by":"crossref","first-page":"C89","DOI":"10.1152\/ajpcell.00369.2004","volume":"289","author":"B Fioretti","year":"2005","unstructured":"Fioretti, B., Pietrangelo, T., Catacuzzeno, L., & Franciolini, F. (2005). Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. American Journal of Physiology. Cell Physiology, 289, C89\u2013C96.","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"9442_CR45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF01869613","volume":"97","author":"JJ Bolivar","year":"1987","unstructured":"Bolivar, J. J., & Cereijido, M. (1987). Voltage and Ca2+-activated K+ channel in cultured epithelial cells (MDCK). The Journal of membrane biology, 97, 43\u201351.","journal-title":"The Journal of membrane biology"},{"key":"9442_CR46","first-page":"82","volume":"13","author":"F Lang","year":"1990","unstructured":"Lang, F., Friedrich, F., Paulmichl, M., Schobersberger, W., Jungwirth, A., Ritter, M., et al. (1990). Ion channels in Madin\u2013Darby canine kidney cells. Renal Physiology and Biochemistry, 13, 82\u201393.","journal-title":"Renal Physiology and Biochemistry"},{"key":"9442_CR47","doi-asserted-by":"crossref","first-page":"F507","DOI":"10.1152\/ajprenal.00222.2010","volume":"299","author":"JD Holtzclaw","year":"2010","unstructured":"Holtzclaw, J. D., Liu, L., Grimm, P. R., & Sansom, S. C. (2010). Shear stress-induced volume decrease in C11-MDCK cells by bk-alpha\/beta4. American journal of physiology: Renal physiology, 299, F507\u2013F516.","journal-title":"American journal of physiology: Renal physiology"},{"key":"9442_CR48","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00233450","volume":"143","author":"D Talavera","year":"1995","unstructured":"Talavera, D., Ponce, A., Fiorentino, R., Gonzalez-Mariscal, L., Contreras, R. G., Sanchez, S. H., et al. (1995). Expression of potassium channels in epithelial cells depends on calcium-activated cell\u2013cell contacts. The Journal of membrane biology, 143, 219\u2013226.","journal-title":"The Journal of membrane biology"},{"issue":"Pt 1","key":"9442_CR49","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1042\/bj3220259","volume":"322","author":"A Mohamed","year":"1997","unstructured":"Mohamed, A., Ferguson, D., Seibert, F. S., Cai, H. M., Kartner, N., Grinstein, S., et al. (1997). Functional expression and apical localization of the cystic fibrosis transmembrane conductance regulator in MDCK I cells. Biochemical Journal, 322(Pt 1), 259\u2013265.","journal-title":"Biochemical Journal"},{"key":"9442_CR50","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/BF00583597","volume":"403","author":"HA Kolb","year":"1985","unstructured":"Kolb, H. A., Brown, C. D., & Murer, H. (1985). Identification of a voltage-dependent anion channel in the apical membrane of a Cl(-)-secretory epithelium (MDCK). Pflugers Archiv. European Journal of Physiology, 403, 262\u2013265.","journal-title":"Pflugers Archiv. European Journal of Physiology"},{"key":"9442_CR51","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/356238a0","volume":"356","author":"M Paulmichl","year":"1992","unstructured":"Paulmichl, M., Li, Y., Wickman, K., Ackerman, M., Peralta, E., & Clapham, D. (1992). New mammalian chloride channel identified by expression cloning. Nature, 356, 238\u2013241.","journal-title":"Nature"},{"key":"9442_CR52","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-physiol-021909-135811","volume":"72","author":"C Duran","year":"2010","unstructured":"Duran, C., Thompson, C. H., Xiao, Q., & Hartzell, H. C. (2010). Chloride channels: Often enigmatic, rarely predictable. Annual Review of Physiology, 72, 95\u2013121.","journal-title":"Annual Review of Physiology"},{"key":"9442_CR53","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cell.2007.03.034","volume":"129","author":"DE Clapham","year":"2007","unstructured":"Clapham, D. E. (2007). Snapshot: Mammalian Trp channels. Cell, 129, 220.","journal-title":"Cell"},{"key":"9442_CR54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1113\/jphysiol.2004.061267","volume":"558","author":"HE Farris","year":"2004","unstructured":"Farris, H. E., LeBlanc, C. L., Goswami, J., & Ricci, A. J. (2004). Probing the pore of the auditory hair cell mechanotransducer channel in turtle. The Journal of physiology, 558, 769\u2013792.","journal-title":"The Journal of physiology"},{"key":"9442_CR55","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bpj.2009.11.007","volume":"98","author":"Y Karashima","year":"2010","unstructured":"Karashima, Y., Prenen, J., Talavera, K., Janssens, A., Voets, T., & Nilius, B. (2010). Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel Trpa1. Biophysical Journal, 98, 773\u2013783.","journal-title":"Biophysical Journal"},{"key":"9442_CR56","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1085\/jgp.200810051","volume":"132","author":"A Jara-Oseguera","year":"2008","unstructured":"Jara-Oseguera, A., Llorente, I., Rosenbaum, T., & Islas, L. D. (2008). Properties of the inner pore region of Trpv1 channels revealed by block with quaternary ammoniums. The Journal of general physiology, 132, 547\u2013562.","journal-title":"The Journal of general physiology"},{"key":"9442_CR57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","volume":"76","author":"K Venkatachalam","year":"2007","unstructured":"Venkatachalam, K., & Montell, C. (2007). Trp channels. Annual Review of Biochemistry, 76, 387\u2013417.","journal-title":"Annual Review of Biochemistry"},{"issue":"179","key":"9442_CR58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-540-34891-7_9","volume":"179","author":"SC Pingle","year":"2007","unstructured":"Pingle, S. C., Matta, J. A., & Ahern, G. P. (2007). Capsaicin receptor: Trpv1 a promiscuous trp channel. Handbook of Experimental Pharmacology, 179(179), 155\u2013171.","journal-title":"Handbook of Experimental Pharmacology"},{"issue":"9","key":"9442_CR59","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1096\/fj.11-183145","volume":"25","author":"Z-G Jiang","year":"2011","unstructured":"Jiang, Z. -G., Wang, T., Karasawa, T., & Yang, Y. -Q. (2011). A functional channel in kidney epithelial cells exhibit characteristics of gentamicin uptake-related trpv4 channel. FASEB Journal, 25(9), 3197\u20133207.","journal-title":"FASEB Journal"},{"key":"9442_CR60","volume-title":"Ionic channels of excitable membranes","author":"B Hille","year":"2001","unstructured":"Hille, B. (2001). Ionic channels of excitable membranes (3rd ed.). Sunderland, MA: Sinauer Associates Inc.","edition":"3"},{"key":"9442_CR61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s004240100629","volume":"443","author":"M Glanville","year":"2001","unstructured":"Glanville, M., Kingscote, S., Thwaites, D. T., & Simmons, N. L. (2001). Expression and role of sodium, potassium, chloride cotransport (NKCC1) in mouse inner medullary collecting duct (mIMCD-k2) epithelial cells. Pflugers Archiv. European Journal of Physiology, 443, 123\u2013131.","journal-title":"Pflugers Archiv. European Journal of Physiology"},{"issue":"Pt 3","key":"9442_CR62","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1113\/jphysiol.1995.sp020834","volume":"486","author":"C Delles","year":"1995","unstructured":"Delles, C., Haller, T., & Dietl, P. (1995). A highly calcium-selective cation current activated by intracellular calcium release in MDCK cells. The Journal of physiology, 486(Pt 3), 557\u2013569.","journal-title":"The Journal of physiology"},{"key":"9442_CR63","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/j.1552-4604.1982.tb02670.x","volume":"22","author":"DH Lawson","year":"1982","unstructured":"Lawson, D. H., Tilstone, W. J., Gray, J. M., & Srivastava, P. K. (1982). Effect of furosemide on the pharmacokinetics of gentamicin in patients. Journal of Clinical Pharmacology, 22, 254\u2013258.","journal-title":"Journal of Clinical Pharmacology"},{"key":"9442_CR64","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/01.RES.0000233356.10630.8a","volume":"99","author":"R Inoue","year":"2006","unstructured":"Inoue, R., Jensen, L. J., Shi, J., Morita, H., Nishida, M., Honda, A., et al. (2006). Transient receptor potential channels in cardiovascular function and disease. Circulation Research, 99, 119\u2013131.","journal-title":"Circulation Research"},{"key":"9442_CR65","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1113\/jphysiol.2004.080960","volume":"564","author":"ZG Jiang","year":"2005","unstructured":"Jiang, Z. G., Nuttall, A. L., Zhao, H., Dai, C. F., Guan, B. C., Si, J. Q., et al. (2005). Electrical coupling and release of K+ from endothelial cells co-mediate Ach-induced smooth muscle hyperpolarization in guinea-pig inner ear artery. The Journal of physiology, 564, 475\u2013487.","journal-title":"The Journal of physiology"},{"key":"9442_CR66","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.heares.2008.01.005","volume":"239","author":"K-T Ma","year":"2008","unstructured":"Ma, K. -T., Guan, B. -C., Yang, Y. Q., Zhao, H., & Jiang, Z. -G. (2008). Ach-induced depolarization in inner ear artery is generated by activation of a Trp-like non-selective cation conductance and inactivation of a potassium conductance. Hearing Research, 239, 20\u201333.","journal-title":"Hearing Research"},{"key":"9442_CR67","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/00016480510038572","volume":"125","author":"M Takumida","year":"2005","unstructured":"Takumida, M., Kubo, N., Ohtani, M., Suzuka, Y., & Anniko, M. (2005). Transient receptor potential channels in the inner ear: Presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear. Acta Oto-Laryngologica, 125, 929\u2013934.","journal-title":"Acta Oto-Laryngologica"},{"key":"9442_CR68","doi-asserted-by":"crossref","unstructured":"Shen, Z., & Marcus, D. C. (1998). Divalent cations inhibit IsK\/KvLQT1 channels in excised membrane patches of strial marginal cells. Hearing Research, 123, 157\u2013167.","DOI":"10.1016\/S0378-5955(98)00110-5"},{"key":"9442_CR69","doi-asserted-by":"crossref","unstructured":"Teramoto, N., Tomoda, T., Yunoki, T., & Ito, Y. (2006). Different glibenclamide-sensitivity of ATP-sensitive K+ currents using different patch-clamp recording methods. European Journal of Pharmacology, 531, 34\u201340.","DOI":"10.1016\/j.ejphar.2005.12.011"},{"key":"9442_CR70","doi-asserted-by":"crossref","unstructured":"Bourcier, N., Grygorczyk, R., Gekle, M., Berthiaume, Y., & Orlov, S. N. (2002). Purinergic-induced ion current in monolayers of C7-MDCK cells: Role of basolateral and apical ion transporters. The Journal of Membrane Biology, 186, 131\u2013143.","DOI":"10.1007\/s00232-001-0141-y"},{"key":"9442_CR71","doi-asserted-by":"crossref","unstructured":"Schwab, A., Wulf, A., Schulz, C., Kessler, W., Nechyporuk-Zloy, V., Romer, M., et al. (2006). Subcellular distribution of calcium-sensitive potassium channels (IK1) in migrating cells. Journal of Cellular Physiology, 206, 86\u201394.","DOI":"10.1002\/jcp.20434"},{"key":"9442_CR72","doi-asserted-by":"crossref","unstructured":"Reinhardt, J., Golenhofen, N., Pongs, O., Oberleithner, H., & Schwab, A. (1998). Migrating transformed MDCK cells are able to structurally polarize a voltage-activated K+ channel. Proceedings of the National Academy of Sciences of the United States of America, 95, 5378\u20135382.","DOI":"10.1073\/pnas.95.9.5378"},{"key":"9442_CR73","doi-asserted-by":"crossref","unstructured":"Jiang, Z. -G., Shi, X. R., Zhao, H., Si, J. Q., & Nuttall, A. L. (2004). Basal nitric oxide production contributes to membrane potential and vasotone regulation of guinea pig in vitro spiral modiolar artery. Hearing Research, 189, 92\u2013100.","DOI":"10.1016\/S0378-5955(03)00398-8"},{"key":"9442_CR74","unstructured":"Di Stefano, A., Wittner, M., Schlatter, E., Lang, H. J., Englert, H., & Greger, R. (1985). Diphenylamine-2-carboxylate, a blocker of the Cl(-)-conductive pathway in Cl(-)-transporting epithelia. Pflugers Archiv : European Journal of Physiology, 405(Suppl 1), S95\u2013100."},{"key":"9442_CR75","doi-asserted-by":"crossref","unstructured":"Hartzell, C., Putzier, I., & Arreola, J. (2005). Calcium-activated chloride channels. Annual Review of Physiology, 67, 719\u2013758.","DOI":"10.1146\/annurev.physiol.67.032003.154341"},{"key":"9442_CR76","doi-asserted-by":"crossref","unstructured":"Liantonio, A., Picollo, A., Babini, E., Carbonara, G., Fracchiolla, G., Loiodice, F., et al. (2006). Activation and inhibition of kidney CLC-K chloride channels by fenamates. Molecular pharmacology, 69, 165\u2013173.","DOI":"10.1124\/mol.105.017384"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-012-9442-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-012-9442-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-012-9442-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T17:01:58Z","timestamp":1643562118000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-012-9442-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,30]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["9442"],"URL":"https:\/\/doi.org\/10.1007\/s12013-012-9442-2","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,30]]}}}