{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:51:02Z","timestamp":1791049862567,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2013,6,2]],"date-time":"2013-06-02T00:00:00Z","timestamp":1370131200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s12013-013-9670-0","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T05:54:32Z","timestamp":1370066072000},"page":"1379-1389","source":"Crossref","is-referenced-by-count":10,"title":["Inactivation of HDAC3 and STAT3 is Critically Involved in 1-Stearoyl-sn-Glycero-3-Phosphocholine-Induced Apoptosis in Chronic Myelogenous Leukemia K562 Cells"],"prefix":"10.1007","volume":"67","author":[{"given":"Ji Hoon","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ki","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok-Beom","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duckgu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyong","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,2]]},"reference":[{"key":"9670_CR1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2741\/e388","volume":"4","author":"A Ahmad","year":"2012","unstructured":"Ahmad, A., Sakr, W. A., & Rahman, K. M. (2012). Novel targets for detection of cancer and their modulation by chemopreventive natural compounds. Frontiers in Bioscience (Elite Edition), 4, 410\u2013425.","journal-title":"Frontiers in Bioscience (Elite Edition)"},{"issue":"7","key":"9670_CR2","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1158\/0008-5472.CAN-07-5807","volume":"68","author":"YC Lin","year":"2008","unstructured":"Lin, Y. C., Lin, J. H., Chou, C. W., Chang, Y. F., Yeh, S. H., & Chen, C. C. (2008). Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1\/2. Cancer Research, 68(7), 2375\u20132383.","journal-title":"Cancer Research"},{"issue":"4","key":"9670_CR3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/jcb.22185","volume":"107","author":"PA Marks","year":"2009","unstructured":"Marks, P. A., & Xu, W. S. (2009). Histone deacetylase inhibitors: Potential in cancer therapy. Journal of Cellular Biochemistry, 107(4), 600\u2013608.","journal-title":"Journal of Cellular Biochemistry"},{"key":"9670_CR4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1749-6632.2009.04911.x","volume":"1171","author":"BB Aggarwal","year":"2009","unstructured":"Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Gupta, S. R., Tharakan, S. T., Koca, C., et al. (2009). Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship? Annals of the New York Academy Sciences, 1171, 59\u201376.","journal-title":"Annals of the New York Academy Sciences"},{"issue":"2","key":"9670_CR5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ijc.25059","volume":"127","author":"MK Pandey","year":"2010","unstructured":"Pandey, M. K., Sung, B., & Aggarwal, B. B. (2010). Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. International Journal of Cancer, 127(2), 82\u2013292.","journal-title":"International Journal of Cancer"},{"issue":"1","key":"9670_CR6","doi-asserted-by":"crossref","first-page":"G77","DOI":"10.1152\/ajpgi.00301.2011","volume":"302","author":"K Kakisaka","year":"2012","unstructured":"Kakisaka, K., Cazanave, S. C., Fingas, C. D., Guicciardi, M. E., Bronk, S. F., Werneburg, N. W., et al. (2012). Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis. American Journal of Physiology. Gastrointestinal and Liver Physiology, 302(1), G77\u2013G84.","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"issue":"1","key":"9670_CR7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1158\/1535-7163.MCT-10-0474","volume":"10","author":"P Jantscheff","year":"2011","unstructured":"Jantscheff, P., Schlesinger, M., Fritzsche, J., Taylor, L. A., Graeser, R., Kirfel, G., et al. (2011). Lysophosphatidylcholine pretreatment reduces VLA-4 and P-selectin-mediated b16.f10 melanoma cell adhesion in vitro and inhibits metastasis-like lung invasion in vivo. Molecular Cancer Therapeutics, 10(1), 186\u2013197.","journal-title":"Molecular Cancer Therapeutics"},{"issue":"9","key":"9670_CR8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/mc.20524","volume":"48","author":"CG Gaetano","year":"2009","unstructured":"Gaetano, C. G., Samadi, N., Tomsig, J. L., Macdonald, T. L., Lynch, K. R., & Brindley, D. N. (2009). Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Molecular Carcinogenesis, 48(9), 801\u2013809.","journal-title":"Molecular Carcinogenesis"},{"issue":"4","key":"9670_CR9","first-page":"375","volume":"61","author":"S Park","year":"2010","unstructured":"Park, S., Kim, J. A., Choi, S., & Suh, S. H. (2010). Superoxide is a potential culprit of caspase-3 dependent endothelial cell death induced by lysophosphatidylcholine. Journal of Physiology and Pharmacology, 61(4), 375\u2013381.","journal-title":"Journal of Physiology and Pharmacology"},{"issue":"12","key":"9670_CR10","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s00432-006-0125-5","volume":"132","author":"GY Gwak","year":"2006","unstructured":"Gwak, G. Y., Yoon, J. H., Lee, S. H., Lee, S. M., Lee, H. S., & Gores, G. J. (2006). Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes. Journal of Cancer Research and Clinical Oncology, 132(12), 771\u2013779.","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"9670_CR11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1476-511X-6-17","volume":"6","author":"LA Taylor","year":"2007","unstructured":"Taylor, L. A., Arends, J., Hodina, A. K., Unger, C., & Massing, U. (2007). Plasma lyso-phosphatidylcholine concentration is decreased in cancer patients with weight loss and activated inflammatory status. Lipids Health Disease, 6, 17.","journal-title":"Lipids Health Disease"},{"issue":"11","key":"9670_CR12","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/BF02535552","volume":"22","author":"HD Schick","year":"1987","unstructured":"Schick, H. D., Berdel, W. E., Fromm, M., Fink, U., Jehn, U., Ulm, K., et al. (1987). Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. Lipids, 22(11), 904\u2013910.","journal-title":"Lipids"},{"issue":"3","key":"9670_CR13","first-page":"179","volume":"8","author":"ML Jimeno","year":"2002","unstructured":"Jimeno, M. L., Valverde, S., B\u0142aszczak, W., Fornal, J., & Amarowicz, R. (2002). 13C and 1H NMR study of lysophosphatidylcholine (LPC) isolated from the surface of wheat starch granules. Food Science and Technology International, 8(3), 179\u2013183.","journal-title":"Food Science and Technology International"},{"issue":"5","key":"9670_CR14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/ptr.3616","volume":"26","author":"SH Won","year":"2011","unstructured":"Won, S. H., Lee, H. J., Jeong, S. J., Lu, J., & Kim, S. H. (2011). Activation of p53 signaling and inhibition of androgen receptor mediate tanshinone IIA induced G1 arrest in LNCaP prostate cancer cells. Phytotherapy Research, 26(5), 669\u2013674.","journal-title":"Phytotherapy Research"},{"issue":"37","key":"9670_CR15","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1038\/sj.onc.1210620","volume":"26","author":"WS Xu","year":"2007","unstructured":"Xu, W. S., Parmigiani, R. B., & Marks, P. A. (2007). Histone deacetylase inhibitors: Molecular mechanisms of action. Oncogene, 26(37), 5541\u20135552.","journal-title":"Oncogene"},{"issue":"37","key":"9670_CR16","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/sj.onc.1210599","volume":"26","author":"XJ Yang","year":"2007","unstructured":"Yang, X. J., & Seto, E. (2007). HATs and HDACs: From structure, function and regulation to novel strategies for therapy and prevention. Oncogene, 26(37), 5310\u20135318.","journal-title":"Oncogene"},{"issue":"26","key":"9670_CR17","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1200\/JCO.2008.21.3264","volume":"27","author":"M Benekli","year":"2009","unstructured":"Benekli, M., Baumann, H., & Wetzler, M. (2009). Targeting signal transducer and activator of transcription signaling pathway in leukemias. Journal of Clinical Oncology, 27(26), 4422\u20134432.","journal-title":"Journal of Clinical Oncology"},{"issue":"1\u20132","key":"9670_CR18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1385\/IR:35:1:127","volume":"35","author":"FW Tsui","year":"2006","unstructured":"Tsui, F. W., Martin, A., Wang, J., & Tsui, H. W. (2006). Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1. Immunologic Research, 35(1\u20132), 127\u2013136.","journal-title":"Immunologic Research"},{"key":"9670_CR19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1196\/annals.1378.063","volume":"1091","author":"BB Aggarwal","year":"2006","unstructured":"Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K., Pandey, M. K., Kunnumakkara, A. B., et al. (2006). Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: Modern target but ancient solution. Annals of the New York Academy Sciences, 1091, 151\u2013169.","journal-title":"Annals of the New York Academy Sciences"},{"issue":"1","key":"9670_CR20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbalip.2008.09.007","volume":"1791","author":"Y Sun","year":"2009","unstructured":"Sun, Y., Lee, J. H., Kim, N. H., Lee, C. W., Kim, M. J., Kim, S. H., et al. (2009). Lysophosphatidylcholine-induced apoptosis in H19-7 hippocampal progenitor cells is enhanced by the upregulation of Fas ligand. Biochimica et Biophysica Acta, 1791(1), 61\u201368.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"2","key":"9670_CR21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0021-9150(01)00674-8","volume":"161","author":"M Takahashi","year":"2002","unstructured":"Takahashi, M., Okazaki, H., Ogata, Y., Takeuchi, K., Ikeda, U., & Shimada, K. (2002). Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism. Atherosclerosis, 161(2), 387\u2013394.","journal-title":"Atherosclerosis"},{"issue":"4","key":"9670_CR22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/emm.2006.44","volume":"38","author":"DH Yun","year":"2006","unstructured":"Yun, D. H., Jeon, E. S., Sung, S. M., Ryu, S. H., & Kim, J. H. (2006). Lysophosphatidylcholine suppresses apoptosis and induces neurite outgrowth in PC12 cells through activation of phospholipase D2. Experimental and Molecular Medicine, 38(4), 375\u2013384.","journal-title":"Experimental and Molecular Medicine"},{"issue":"10","key":"9670_CR23","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/stem.185","volume":"27","author":"MM Sherry","year":"2009","unstructured":"Sherry, M. M., Reeves, A., Wu, J. K., & Cochran, B. H. (2009). STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells, 27(10), 2383\u20132392.","journal-title":"Stem Cells"},{"issue":"10","key":"9670_CR24","doi-asserted-by":"crossref","first-page":"48160","DOI":"10.1371\/journal.pone.0048160","volume":"7","author":"AL Mencalha","year":"2012","unstructured":"Mencalha, A. L., Binato, R., Ferreira, G. M., Du Rocher, B., & Abdelhay, E. (2012). Forkhead box M1 (FoxM1) gene is a new STAT3 transcriptional factor target and is essential for proliferation, survival and DNA repair of K562 cell line. PLoS One, 7(10), 48160.","journal-title":"PLoS One"},{"issue":"37","key":"9670_CR25","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1038\/sj.onc.1210610","volume":"26","author":"MA Glozak","year":"2007","unstructured":"Glozak, M. A., & Seto, E. (2007). Histone deacetylases and cancer. Oncogene, 26(37), 5420\u20135432.","journal-title":"Oncogene"},{"issue":"4","key":"9670_CR26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.biocel.2008.05.026","volume":"41","author":"R Codd","year":"2009","unstructured":"Codd, R., Braich, N., Liu, J., Soe, C. Z., & Pakchung, A. A. (2009). Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A. International Journal of Biochemistry & Cell Biology, 41(4), 736\u2013739.","journal-title":"International Journal of Biochemistry & Cell Biology"},{"issue":"5","key":"9670_CR27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1517\/13543784.16.5.659","volume":"16","author":"WK Rasheed","year":"2007","unstructured":"Rasheed, W. K., Johnstone, R. W., & Prince, H. M. (2007). Histone deacetylase inhibitors in cancer therapy. Expert Opinion on Investigational Drugs, 16(5), 659\u2013678.","journal-title":"Expert Opinion on Investigational Drugs"},{"issue":"13","key":"9670_CR28","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1158\/0008-5472.CAN-05-4563","volume":"66","author":"S Inoue","year":"2006","unstructured":"Inoue, S., Mai, A., Dyer, M. J., & Cohen, G. M. (2006). Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Research, 66(13), 6785\u20136792.","journal-title":"Cancer Research"},{"issue":"11","key":"9670_CR29","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","volume":"9","author":"H Yu","year":"2009","unstructured":"Yu, H., Pardoll, D., & Jove, R. (2009). STATs in cancer inflammation and immunity: A leading role for STAT3. Nature Reviews Cancer, 9(11), 798\u2013809.","journal-title":"Nature Reviews Cancer"},{"issue":"14","key":"9670_CR30","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1158\/0008-5472.CAN-09-0536","volume":"69","author":"NH Thoennissen","year":"2009","unstructured":"Thoennissen, N. H., Iwanski, G. B., Doan, N. B., Okamoto, R., Lin, P., Abbassi, S., et al. (2009). Cucurbitacin B induces apoptosis by inhibition of the JAK\/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Research, 69(14), 5876\u20135884.","journal-title":"Cancer Research"},{"issue":"5","key":"9670_CR31","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1158\/0008-5472.CAN-08-2944","volume":"69","author":"B Sen","year":"2009","unstructured":"Sen, B., Saigal, B., Parikh, N., Gallick, G., & Johnson, F. M. (2009). Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding. Cancer Research, 69(5), 1958\u20131965.","journal-title":"Cancer Research"},{"key":"9670_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00400-1","volume":"306","author":"C Wu","year":"2003","unstructured":"Wu, C., Sun, M., Liu, L., & Zhou, G. W. (2003). The function of the protein tyrosine phosphatase SHP-1 in cancer. Gene, 306, 1\u201312.","journal-title":"Gene"},{"issue":"9","key":"9670_CR33","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/sj.leu.2402214","volume":"15","author":"B Bruecher-Encke","year":"2001","unstructured":"Bruecher-Encke, B., Griffin, J. D., Neel, B. G., & Lorenz, U. (2001). Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation. Leukemia, 15(9), 1424\u20131432.","journal-title":"Leukemia"},{"key":"9670_CR34","first-page":"pe30","volume":"343","author":"SP Gao","year":"2006","unstructured":"Gao, S. P., & Bromberg, J. F. (2006). Touched and moved by STAT3. Science\u2019s STKE: Signal Transduction Knowledge Environment, 343, pe30.","journal-title":"Science\u2019s STKE: Signal Transduction Knowledge Environment"},{"issue":"21","key":"9670_CR35","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1182\/blood-2009-07-231985","volume":"115","author":"TY Lin","year":"2010","unstructured":"Lin, T. Y., Fenger, J., Murahari, S., Bear, M. D., Kulp, S. K., Wang, D., et al. (2010). AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated kit. Blood, 115(21), 4217\u20134225.","journal-title":"Blood"},{"issue":"2","key":"9670_CR36","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbrc.2008.12.132","volume":"379","author":"S Togi","year":"2009","unstructured":"Togi, S., Kamitani, S., Kawakami, S., Ikeda, O., Muromoto, R., Nanbo, A., et al. (2009). HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A. Biochemical and Biophysical Research Communications, 379(2), 616\u2013620.","journal-title":"Biochemical and Biophysical Research Communications"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-013-9670-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-013-9670-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-013-9670-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T13:34:52Z","timestamp":1715434492000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-013-9670-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,2]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["9670"],"URL":"https:\/\/doi.org\/10.1007\/s12013-013-9670-0","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,2]]}}}