{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T21:53:21Z","timestamp":1721858001472},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T00:00:00Z","timestamp":1399766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s12013-014-0002-9","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T05:58:04Z","timestamp":1399701484000},"page":"939-956","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["An Integrated in Silico Approach to Analyze the Involvement of Single Amino Acid Polymorphisms in FANCD1\/BRCA2-PALB2 and FANCD1\/BRCA2-RAD51 Complex"],"prefix":"10.1007","volume":"70","author":[{"given":"C. George Priya","family":"Doss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Nagasundaram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,11]]},"reference":[{"key":"2_CR1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ng1458","volume":"36","author":"AR Meetei","year":"2004","unstructured":"Meetei, A. R., Levitus, M., Xue, Y., Medhurst, A. L., Zwaan, M., et al. (2004). X-linked inheritance of Fanconi anemia complementation group B. Nature Genetics, 36, 1219\u20131224.","journal-title":"Nature Genetics"},{"key":"2_CR2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ng1947","volume":"39","author":"S Reid","year":"2007","unstructured":"Reid, S., Schindler, D., Hanenberg, H., Barker, K., Hanks, S., et al. (2007). Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nature Genetics, 39, 162\u2013164.","journal-title":"Nature Genetics"},{"issue":"6","key":"2_CR3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2006.05.022","volume":"22","author":"B Xia","year":"2006","unstructured":"Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., et al. (2006). Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Molecular Cell, 22(6), 719\u2013729.","journal-title":"Molecular Cell"},{"key":"2_CR4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/87876","volume":"7","author":"KN Nathanson","year":"2001","unstructured":"Nathanson, K. N., Wooster, R., & Weber, B. L. (2001). Breast cancer genetics: What we know and what we need. Nature Medicine, 7, 552\u2013556.","journal-title":"Nature Medicine"},{"key":"2_CR5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/378789a0","volume":"378","author":"R Wooster","year":"1995","unstructured":"Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., et al. (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature, 378, 789\u2013792.","journal-title":"Nature"},{"key":"2_CR6","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","volume":"62","author":"D Ford","year":"1998","unstructured":"Ford, D., Easton, D. F., Stratton, M., Narod, S., Goldgar, D., et al. (1998). Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. American Journal of Human Genetics, 62, 676\u2013689.","journal-title":"American Journal of Human Genetics"},{"key":"2_CR7","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.2270482","volume":"250","author":"JM Hall","year":"1990","unstructured":"Hall, J. M., Lee, M. K., Newman, B., Morrow, J. E., Anderson, L. A., et al. (1990). Linkage of early- onset familial breast cancer to chromosome 17q21. Science, 250, 1684\u20131689.","journal-title":"Science"},{"key":"2_CR8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1101\/gr.8.12.1229","volume":"8","author":"FS Collins","year":"1998","unstructured":"Collins, F. S., Brooks, L. D., & Chakravarti, A. (1998). A DNA polymorphism discovery resource for research on human genetic variation. Genome Research, 8, 1223\u20131229.","journal-title":"Genome Research"},{"key":"2_CR9","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jmb.2005.12.025","volume":"356","author":"P Yue","year":"2006","unstructured":"Yue, P., & Moult, J. (2006). Identification and analysis of deleterious human SNPs. Journal of Molecular Biology, 356, 1263\u20131274.","journal-title":"Journal of Molecular Biology"},{"key":"2_CR10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/nar\/gkh104","volume":"32","author":"NO Stitziel","year":"2004","unstructured":"Stitziel, N. O., Binkowski, T. A., Tseng, Y. Y., Kasif, S., & Liang, J. (2004). TopoSNP: A topographic database of non-synonymous single nucleotide polymorphisms with and without known disease association. Nucleic Acids Research, 32, 52\u2013522.","journal-title":"Nucleic Acids Research"},{"key":"2_CR11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/nar\/gkm232","volume":"35","author":"A Uzun","year":"2007","unstructured":"Uzun, A., Leslin, C. M., Abyzov, A., & Ilyin, V. (2007). Structure SNP (StSNP): A web server for mapping and modeling nsSNPs on protein structures with linkage to metabolic pathways. Nucleic Acids Research, 35, 384\u2013392.","journal-title":"Nucleic Acids Research"},{"key":"2_CR12","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1093\/nar\/gkf493","volume":"30","author":"V Ramensky","year":"2002","unstructured":"Ramensky, V., Bork, P., & Sunyaev, S. (2002). Human non-synonymous SNPs: Server and survey. Nucleic Acids Research, 30, 3894\u20133900.","journal-title":"Nucleic Acids Research"},{"key":"2_CR13","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/humu.10212","volume":"21","author":"PD Stenson","year":"2003","unstructured":"Stenson, P. D., Ball, E. V., Mort, M., Phillips, A. D., Shiel, J. A., et al. (2003). Human gene mutation database (HGMD) 2003 update. Human Mutation, 21, 577\u2013581.","journal-title":"Human Mutation"},{"key":"2_CR14","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","volume":"316","author":"S Matsuoka","year":"2007","unstructured":"Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R, I. I. I., Hurov, K. E., et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science, 316, 1160\u20131166.","journal-title":"Science"},{"key":"2_CR15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/humu.9174","volume":"22","author":"P Meyer","year":"2003","unstructured":"Meyer, P., Voigtlaender, T., Bartram, C. R., & Klaes, R. (2003). Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and\/or ovarian cancer families in Southern Germany. Human Mutation, 22, 259.","journal-title":"Human Mutation"},{"key":"2_CR16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng1959","volume":"39","author":"N Rahman","year":"2007","unstructured":"Rahman, N., Seal, S., Thompson, D., Thompson, D., Kelly, P., Renwick, A., et al. (2007). PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nature Genetics, 39, 165\u2013167.","journal-title":"Nature Genetics"},{"issue":"19","key":"2_CR17","first-page":"323","volume":"108","author":"A Meindl","year":"2011","unstructured":"Meindl, A., Ditsch, N., Kast, K., Rhiem, K., & Schmutzler, R. K. (2011). Hereditary breast and ovarian cancer: New genes, new treatments, new concepts. Deutsches Arzteblatt International, 108(19), 323\u2013330.","journal-title":"Deutsches Arzteblatt International"},{"key":"2_CR18","doi-asserted-by":"crossref","unstructured":"George Priya Doss, C. (2012) In Silico Profiling of deleterious amino acid substitutions of potential pathological importance in Hemophilia A and Hemophilia B. BMC Journal of biomedical science, 19, 30.","DOI":"10.1186\/1423-0127-19-30"},{"issue":"4","key":"2_CR19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10689-009-9241-0","volume":"8","author":"M Sluiter","year":"2009","unstructured":"Sluiter, M., Mew, S., & van Rensburg, E. J. (2009). PALB2 sequence variants in young South African breast cancer patients. Familial Cancer, 8(4), 347\u2013353.","journal-title":"Familial Cancer"},{"key":"2_CR20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/humu.21445","volume":"32","author":"J Thusberg","year":"2011","unstructured":"Thusberg, J., Olatubosun, A., & Vihinen, M. (2011). Performance of mutation pathogenicity prediction methods on missense variants. Human Mutation, 32, 358\u2013368.","journal-title":"Human Mutation"},{"key":"2_CR21","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/bioinformatics\/btl423","volume":"22","author":"E Capriotti","year":"2006","unstructured":"Capriotti, E., Calabrese, R., & Casadio, R. (2006). Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information. Bioinformatics, 22, 2729\u20132734.","journal-title":"Bioinformatics"},{"key":"2_CR22","doi-asserted-by":"crossref","unstructured":"Capriotti, E., Fariselli, P., Rossi, I., & Casadio, R. (2008). A three-state prediction of single point mutations on protein stability changes. BMC Bioinfomatics,\u00a09, S6.","DOI":"10.1186\/1471-2105-9-S2-S6"},{"key":"2_CR23","doi-asserted-by":"crossref","first-page":"42105","DOI":"10.1074\/jbc.M110.172098","volume":"285","author":"MN Offman","year":"2010","unstructured":"Offman, M. N., Krol, M., Silman, I., Sussman, J. L., & Futerman, A. H. (2010). Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S. Journal of Biological Chemistry, 285, 42105\u201342114.","journal-title":"Journal of Biological Chemistry"},{"key":"2_CR24","doi-asserted-by":"crossref","first-page":"e31677","DOI":"10.1371\/journal.pone.0031677","volume":"7","author":"C George Priya Doss","year":"2012","unstructured":"George Priya Doss. C., & NagaSundaram, N. (2012). Investigating the structural impacts of I64T and P311S mutations in APE1-DNA complex: A molecular dynamics approach. PLoS ONE, 7, e31677.","journal-title":"PLoS ONE"},{"key":"2_CR25","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12013-012-9512-5","volume":"66","author":"N Nagasundaram","year":"2013","unstructured":"Nagasundaram, N., & George Priya Doss, C. (2013). Predicting the impact of single nucleotide polymorphisms in CDK2-Flavopiridol complex by molecular dynamics analysis. Cell Biochemistry and Biophysics, 66, 681\u2013695.","journal-title":"Cell Biochemistry and Biophysics"},{"key":"2_CR26","unstructured":"John, A. M., George Priya Doss, C., Ebenazer, A., Seshadri, M. S., Nair, A., Rajaratnam, S., et al. (2013). p.Arg82Leu von Hippel Lindau (VHL) gene mutation among three members of a family with familial bilateral pheochromocytoma in India: Molecular analysis and in silico characterization. PLoS ONE, 8, e61908."},{"key":"2_CR27","doi-asserted-by":"crossref","unstructured":"Kumar, P., Henikoff, S., & Ng, P. C. (2009). SIFT: Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nature Protocols, 4, 1073\u20131081.","DOI":"10.1038\/nprot.2009.86"},{"key":"2_CR28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/nar\/gkl869","volume":"35","author":"H Mi","year":"2007","unstructured":"Mi, H., Guo, N., Kejariwal, A., & Thomas, P. D. (2007). PANTHER version 6: Protein sequence and function evolution data with expanded representation of biological pathways. Nucleic Acids Research, 35, 247\u2013252.","journal-title":"Nucleic Acids Research"},{"key":"2_CR29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/nar\/gki375","volume":"33","author":"E Capriotti","year":"2005","unstructured":"Capriotti, E., Fariselli, P., & Casadio, R. (2005). I-Mutant 2.0: Predicting stability changes upon mutation from the protein sequence or structure. Nucleic Acids Research, 33, 306\u2013310.","journal-title":"Nucleic Acids Research"},{"issue":"Suppl 2","key":"2_CR30","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2164-11-S2-S5","volume":"11","author":"S Teng","year":"2010","unstructured":"Teng, S., Srivastava, A. K., & Wang, L. (2010). Sequence feature-based prediction of protein stability changes upon amino acid substitutions. BMC Genomics, 11(Suppl 2), S5.","journal-title":"BMC Genomics"},{"key":"2_CR31","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","volume":"18","author":"N Guex","year":"1997","unstructured":"Guex, N., & Peitsch, M. C. (1997). SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling. Electrophoresis, 18, 2714\u20132723.","journal-title":"Electrophoresis"},{"key":"2_CR32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","volume":"4","author":"B Hess","year":"2008","unstructured":"Hess, B., Kutzner, C., van der Spoel, D., & Lindahl, E. (2008). GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation. Journal of Chemical Theory and Computation, 4, 435\u2013447.","journal-title":"Journal of Chemical Theory and Computation"},{"key":"2_CR33","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jcc.20703","volume":"28","author":"C Kutzner","year":"2007","unstructured":"Kutzner, C., van der Spoel, D., Fechner, M., Lindahl, E., Schmittn, U. W., De Groot, B. L., et al. (2007). Speeding up parallel GROMACS on high-latency networks. Journal of Computational Chemistry, 28, 2075\u20132084.","journal-title":"Journal of Computational Chemistry"},{"issue":"1","key":"2_CR34","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","volume":"29","author":"ST Sherry","year":"2001","unstructured":"Sherry, S. T., Ward, M. H., Kholodov, M., Baker, J., Phan, L., Smigielski, E. M., et al. (2001). dbSNP: The NCBI database of genetic variation. Nucleic Acids Research, 29(1), 308\u2013311.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"2_CR35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/nar\/24.1.21","volume":"24","author":"B Amos","year":"1996","unstructured":"Amos, B., & Rolf, A. (1996). The SWISS-PROT protein sequence data bank and its new supplement TREMBL. Nucleic Acids Research, 24(1), 21\u201325.","journal-title":"Nucleic Acids Research"},{"key":"2_CR36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/nar\/gkn665","volume":"37","author":"J Amberger","year":"2009","unstructured":"Amberger, J., Bocchini, C. A., Scott, A. F., & Hamosh, A. (2009). McKusick\u2019s Online Mendelian Inheritance in Man (OMIM). Nucleic Acids Research, 37, 793\u2013796.","journal-title":"Nucleic Acids Research"},{"key":"2_CR37","doi-asserted-by":"crossref","unstructured":"Oliver, A. W., Swift, S., Lord, C. J., Ashworth, A., & Pearl, L. H. (2009). Structural basis for recruitment of BRCA2 by PALB2. EMBO Reports, 10, 990\u2013996.","DOI":"10.1038\/embor.2009.126"},{"key":"2_CR38","doi-asserted-by":"crossref","unstructured":"Mark, B. L., Mahuran, D. J., Cherney, M. M., Zhao, D., Knapp, S., & James, M. N. (2003). Crystal structure of human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease. Journal of Molecular Biology, 327, 1093\u2013109.","DOI":"10.1016\/S0022-2836(03)00216-X"},{"key":"2_CR39","doi-asserted-by":"crossref","first-page":"D302","DOI":"10.1093\/nar\/gkj120","volume":"34","author":"A Kouranov","year":"2006","unstructured":"Kouranov, A., Xie, L., de la Cruz, J., Chen, L., Westbrook, J., et al. (2006). The RCSB PDBinformation portal for structural genomics. Nucleic Acids Research, 34, D302\u2013D305.","journal-title":"Nucleic Acids Research"},{"key":"2_CR40","first-page":"1050","volume":"60","author":"P Vehmanen","year":"1997","unstructured":"Vehmanen, P., Friedman, L. S., Eerola, H., Sarantaus, L., Pyrhoenen, S., et al. (1997). A low proportion of BRCA2 mutations in Finnish breast cancer families. American Journal of Human Genetics, 60, 1050\u20131058.","journal-title":"American Journal of Human Genetics"},{"key":"2_CR41","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s004390050936","volume":"104","author":"SSL Li","year":"1999","unstructured":"Li, S. S. L., Tseng, H. M., Yang, T. P., Liu, C. H., Teng, S. J., et al. (1999). Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan. Human Genetics, 104, 201\u2013204.","journal-title":"Human Genetics"},{"key":"2_CR42","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/humu.9084","volume":"20","author":"P Ruiz-Flores","year":"2002","unstructured":"Ruiz-Flores, P., Sinilnikova, O. M., Badzioch, M., Calderon-Garciduenas, A. L., Chopin, S., et al. (2002). BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico. Human Mutation, 20, 474\u2013475.","journal-title":"Human Mutation"},{"key":"2_CR43","first-page":"1121","volume":"8","author":"N Hu","year":"2002","unstructured":"Hu, N., Li, G., Li, W. J., Wang, C., Goldstein, A. M., et al. (2002). Infrequent mutation in the BRCA2 gene in esophageal squamous cell carcinoma. Clinical Cancer Research, 8, 1121\u20131126.","journal-title":"Clinical Cancer Research"},{"key":"2_CR44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/1098-1004(2001)17:1<73::AID-HUMU12>3.0.CO;2-O","volume":"17","author":"E Kwiatkowska","year":"2001","unstructured":"Kwiatkowska, E., Teresiak, M., Lamperska, K. M., Karczewska, A., Breborowicz, D., et al. (2001). BRCA2 germline mutations in male breast cancer patients in the Polish population. Human Mutation, 17, 73.","journal-title":"Human Mutation"},{"key":"2_CR45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s100380050035","volume":"43","author":"T Katagiri","year":"1998","unstructured":"Katagiri, T., Kasumi, F., Yoshimoto, M., Nomizu, T., Asaishi, K., et al. (1998). High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families. Journal of Human Genetics, 43, 42\u201348.","journal-title":"Journal of Human Genetics"},{"key":"2_CR46","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1086\/302583","volume":"65","author":"SA Gayther","year":"1999","unstructured":"Gayther, S. A., Russell, P., Harrington, P., Antoniou, A. C., Easton, D. F., et al. (1999). The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: No evidence for other ovarian cancer-susceptibility genes. American Journal of Human Genetics, 65, 1021\u20131029.","journal-title":"American Journal of Human Genetics"},{"key":"2_CR47","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/sj.bjc.6601656","volume":"90","author":"K Claes","year":"2004","unstructured":"Claes, K., Poppe, B., Coene, I., De Paepe, A., & Messiaen, L. (2004). BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast\/ovarian cancer families. British Journal of Cancer, 90, 1244\u20131251.","journal-title":"British Journal of Cancer"},{"key":"2_CR48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng0696-238","volume":"13","author":"JM Lancaster","year":"1996","unstructured":"Lancaster, J. M., Wooster, R., Mangion, J., Phelan, C. M., Cochran, C., et al. (1996). BRCA2 mutations in primary breast and ovarian cancers. Nature Genetics, 13, 238\u2013240.","journal-title":"Nature Genetics"},{"key":"2_CR49","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1086\/521032","volume":"81","author":"DF Easton","year":"2007","unstructured":"Easton, D. F., Deffenbaugh, A. M., Pruss, D., Frye, C., Wenstrup, R. J., et al. (2007). A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes. American Journal of Human Genetics, 81, 873\u2013883.","journal-title":"American Journal of Human Genetics"},{"key":"2_CR50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/jnci\/95.3.214","volume":"95","author":"SA Hahn","year":"2003","unstructured":"Hahn, S. A., Greenhalf, B., Ellis, I., Sina-Frey, M., Rieder, H., et al. (2003). BRCA2 germline mutations in familial pancreatic carcinoma. Journal of the National Cancer Institute, 95, 214\u2013221.","journal-title":"Journal of the National Cancer Institute"},{"key":"2_CR51","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ejca.2003.09.016","volume":"40","author":"S Malander","year":"2004","unstructured":"Malander, S., Ridderheim, M., Masbaeck, A., Loman, N., Kristoffersson, U., et al. (2004). One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: Results of a prospective study in Southern Sweden. European Journal of Cancer, 40, 422\u2013428.","journal-title":"European Journal of Cancer"},{"key":"2_CR52","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/humu.21267","volume":"31","author":"LC Walker","year":"2010","unstructured":"Walker, L. C., Whiley, P. J., Couch, F. J., Farrugia, D. J., Healey, S., et al. (2010). Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: Implications for prediction of pathogenicity. Human Mutation, 31, 1484\u20131505.","journal-title":"Human Mutation"},{"key":"2_CR53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jmg.2004.025056","volume":"42","author":"SW Kim","year":"2005","unstructured":"Kim, S. W., Lee, C. S., Fey, J. V., Borgen, P. I., & Boyd, J. (2005). Prevalence of BRCA2 mutations in a hospital based series of unselected breast cancer cases. Journal of Medical Genetics, 42, 5.","journal-title":"Journal of Medical Genetics"},{"issue":"3","key":"2_CR54","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1371\/journal.pgen.0030047","volume":"3","author":"B Peng","year":"2007","unstructured":"Peng, B., Amos, C. I., & Kimmel, M. (2007). Forward-time simulations of human populations with complex diseases. PLoS Genetics, 3(3), e47.","journal-title":"PLoS Genetics"},{"key":"2_CR55","first-page":"2738","volume":"56","author":"H Takahashi","year":"1996","unstructured":"Takahashi, H., Chiu, H. C., Bandera, C. A., Behbakht, K., & Liu, P. C. (1996). Mutations of the BRCA2 gene in ovarian carcinomas. Cancer Research, 56, 2738\u20132741.","journal-title":"Cancer Research"},{"key":"2_CR56","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/humu.9083","volume":"20","author":"X Zhi","year":"2002","unstructured":"Zhi, X., Szabo, C., Chopin, S., Suter, N., & Wang, Q. S. (2002). BRCA1 and BRCA2 sequence variants in Chinese breast cancer families. Human Mutation, 20, 474.","journal-title":"Human Mutation"},{"key":"2_CR57","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/(SICI)1097-0215(19990730)82:3<325::AID-IJC3>3.0.CO;2-G","volume":"82","author":"OM Sinilnikova","year":"1999","unstructured":"Sinilnikova, O. M., Egan, K. M., Quinn, J. L., Boutrand, L., Lenoir, G. M., et al. (1999). Germline brca2 sequence variants in patients with ocular melanoma. International Journal of Cancer, 82, 325\u2013328.","journal-title":"International Journal of Cancer"},{"key":"2_CR58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/jmg.37.9.e17","volume":"37","author":"J Plaschke","year":"2000","unstructured":"Plaschke, J., Commer, T., Jacobi, C., Schackert, H. K., & Chang-Claude, J. (2000). BRCA2 germline mutations among early onset breast cancer patients unselected for family history of the disease. Journal of Medical Genetics, 37, 17.","journal-title":"Journal of Medical Genetics"},{"key":"2_CR59","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1086\/342192","volume":"71","author":"JD Fackenthal","year":"2002","unstructured":"Fackenthal, J. D., Cartegni, L., Krainer, A. R., & Olopade, O. I. (2002). BRCA2 T2722R is a deleterious allele that causes exon skipping. American Journal of Human Genetics, 71, 625\u2013631.","journal-title":"American Journal of Human Genetics"},{"key":"2_CR60","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/humu.9082","volume":"20","author":"S Saxena","year":"2002","unstructured":"Saxena, S., Szabo, C. I., Chopin, S., Barjhoux, L., & Sinilnikova, O. (2002). BRCA1 and BRCA2 in Indian breast cancer patients. Human Mutation, 20, 473\u2013474.","journal-title":"Human Mutation"},{"key":"2_CR61","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1182\/blood-2003-06-1970","volume":"103","author":"B Hirsch","year":"2003","unstructured":"Hirsch, B., Shimamura, A., Moreau, L., Baldinger, S., Hag-alshiekh, M., et al. (2003). Association of biallelic BRCA2\/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood. Blood, 103, 2554\u20132559.","journal-title":"Blood"},{"key":"2_CR62","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cancergencyto.2003.09.020","volume":"151","author":"A Hadjisavvas","year":"2004","unstructured":"Hadjisavvas, A., Charalambous, E., Adamou, A., Neuhausen, S. L., Christodoulou, C. G., et al. (2004). Hereditary breast and ovarian cancer in Cyprus: Identification of a founder BRCA2 mutation. Cancer Genetics and Cytogenetics, 151, 152\u2013156.","journal-title":"Cancer Genetics and Cytogenetics"},{"key":"2_CR63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng0696-245","volume":"13","author":"Y Miki","year":"1996","unstructured":"Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T., & Nakamura, Y. (1996). Mutation analysis in the BRCA2 gene in primary breast cancers. Nature Genetics, 13, 245\u2013247.","journal-title":"Nature Genetics"},{"key":"2_CR64","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/humu.7","volume":"17","author":"SM Edwards","year":"2001","unstructured":"Edwards, S. M., Kote-Jarai, Z., Hamoudi, R., & Eeles, R. A. (2001). An improved high throughput heteroduplex mutation detection system for screening BRCA2 mutations-fluorescent mutation detection (F-MD). Human Mutation, 17, 220\u2013232.","journal-title":"Human Mutation"},{"key":"2_CR65","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/humu.9213","volume":"23","author":"MT Valarmathi","year":"2004","unstructured":"Valarmathi, M. T., Sawhney, M., Deo, S. S., Shukla, N. K., & Das, S. N. (2004). Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. Human Mutation, 23, 205.","journal-title":"Human Mutation"},{"key":"2_CR66","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/sj.bjc.6600562","volume":"87","author":"A Jakubowska","year":"2002","unstructured":"Jakubowska, A., Nej, K., Huzarski, T., Scott, R. J., & Lubinski, J. (2002). BRCA2 gene mutations in families with aggregations of breast and stomach cancers. British Journal of Cancer, 87, 888\u2013891.","journal-title":"British Journal of Cancer"},{"key":"2_CR67","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ng0596-123","volume":"13","author":"FJ Couch","year":"1996","unstructured":"Couch, F. J., Farid, L. M., DeShano, M. L., Tavtigian, S. V., & Calzone, K. (1996). BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nature Genetics, 13, 123\u2013125.","journal-title":"Nature Genetics"},{"key":"2_CR68","first-page":"350","volume":"24","author":"JH Seo","year":"2004","unstructured":"Seo, J. H., Cho, D. Y., Ahn, S. H., Yoon, K. S., & Kang, C. S. (2004). BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. Human Mutation, 24, 350.","journal-title":"Human Mutation"},{"key":"2_CR69","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/humu.9110","volume":"21","author":"A Hadjisavvas","year":"2003","unstructured":"Hadjisavvas, A., Charalambous, E., Adamou, A., Christodoulou, C. G., & Kyriacou, K. (2003). BRCA2 germline mutations in Cypriot patients with familial breast\/ovarian cancer. Human Mutation, 21, 171.","journal-title":"Human Mutation"},{"key":"2_CR70","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s100380300020","volume":"48","author":"M Sakayori","year":"2003","unstructured":"Sakayori, M., Kawahara, M., Shiraishi, K., Nomizu, T., & Shimada, A. (2003). Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1 and BRCA2 genes in familial breast cancer. Journal of Human Genetics, 48, 130\u2013137.","journal-title":"Journal of Human Genetics"},{"key":"2_CR71","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng0396-333","volume":"12","author":"SV Tavtigian","year":"1996","unstructured":"Tavtigian, S. V., Simard, J., Rommens, J., Couch, F., Shattuck-Eidens, D., et al. (1996). The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genetics, 12, 333\u2013337.","journal-title":"Nature Genetics"},{"key":"2_CR72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/10906570260199375","volume":"6","author":"AM Deffenbaugh","year":"2002","unstructured":"Deffenbaugh, A. M., Frank, T. S., Hoffman, M., Cannon-Albright, L., & Neuhausen, S. L. (2002). Characterization of common BRCA1 and BRCA2 variants. Genetic Testing, 6, 119\u2013121.","journal-title":"Genetic Testing"},{"issue":"3","key":"2_CR73","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/humu.9267","volume":"24","author":"A Sharp","year":"2004","unstructured":"Sharp, A., Pichert, G., Lucassen, A., & Eccles, D. (2004). RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1. Human Mutation, 24(3), 272.","journal-title":"Human Mutation"},{"key":"2_CR74","first-page":"3789","volume":"62","author":"KM Murphy","year":"2002","unstructured":"Murphy, K. M., Brune, K. A., Griffin, C., Sollenberger, J. E., & Petersen, G. M. (2002). Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: Deleterious BRCA2 mutations in 17\u00a0%. Cancer Research, 62, 3789\u20133793.","journal-title":"Cancer Research"},{"key":"2_CR75","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0005-2795(75)90109-9","volume":"405","author":"BW Matthews","year":"1975","unstructured":"Matthews, B. W. (1975). Comparison of the predicted and observed secondary structure of T4 phage lysozyme. Biochimica et Biophysica Acta, 405, 442\u2013451.","journal-title":"Biochimica et Biophysica Acta"},{"key":"2_CR76","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/bioinformatics\/16.5.412","volume":"16","author":"P Baldi","year":"2000","unstructured":"Baldi, P., Brunak, S., Chauvin, Y., Andersen, C. A. F., & Nielsen, H. (2000). Assessing the accuracy of prediction algorithms for classification: An overview. Bioinformatics, 16, 412\u2013424.","journal-title":"Bioinformatics"},{"key":"2_CR77","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/humu.21242","volume":"31","author":"S Khan","year":"2010","unstructured":"Khan, S., & Vihinen, M. (2010). Performance of protein stability predictors. Human Mutation, 31, 675\u2013684.","journal-title":"Human Mutation"},{"key":"2_CR78","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jmb.2007.09.061","volume":"375","author":"S Chandrasekar","year":"2008","unstructured":"Chandrasekar, S., Chartron, J., Jaru-Ampornpan, P., & Shan, S. O. (2008). Structure of the chloroplast signal recognition particle (SRP) receptor: Domain arrangement modulates SRP receptor interaction. Journal of Molecular Biology, 375, 425\u2013436.","journal-title":"Journal of Molecular Biology"},{"key":"2_CR79","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1016\/j.febslet.2007.11.024","volume":"581","author":"KF Stengel","year":"2007","unstructured":"Stengel, K. F., Holdermann, I., Wild, K., & Sinning, I. (2007). The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site. FEBS Letters, 581, 5671\u20135676.","journal-title":"FEBS Letters"},{"key":"2_CR80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0968-0004(84)90122-1","volume":"9","author":"AR Fersht","year":"1984","unstructured":"Fersht, A. R. (1984). Basis of biological specificity. Trends in Biochemical Sciences, 9, 145\u2013147.","journal-title":"Trends in Biochemical Sciences"},{"key":"2_CR81","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0065-3233(08)60331-9","volume":"46","author":"B Honig","year":"1995","unstructured":"Honig, B., & Yang, A. S. (1995). Free energy balance in protein folding. Advances in Protein Chemistry, 46, 27\u201358.","journal-title":"Advances in Protein Chemistry"},{"key":"2_CR82","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1021\/bi00118a013","volume":"31","author":"BA Shirley","year":"1992","unstructured":"Shirley, B. A., Stanssens, P., Hahn, U., & Pace, C. N. (1992). Contribution of hydrogen bonding to the conformational stability of ribonuclease T1. Biochemistry, 31, 725\u2013732.","journal-title":"Biochemistry"},{"key":"2_CR83","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0969-2126(00)00072-1","volume":"2","author":"C Wilson","year":"1994","unstructured":"Wilson, C., Mau, T., Weisgraber, K. H., Wardell, M. R., Mahley, R. W., et al. (1994). Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure, 2, 713\u2013718.","journal-title":"Structure"},{"key":"2_CR84","doi-asserted-by":"crossref","first-page":"7621","DOI":"10.1021\/bi9605191","volume":"35","author":"ZS Hendsch","year":"1996","unstructured":"Hendsch, Z. S., Jonsson, T., Sauer, R. T., & Tidor, B. (1996). Protein stabilization by removal of unsatisfied polar groups: Computational approaches and experimental tests. Biochemistry, 35, 7621\u20137625.","journal-title":"Biochemistry"},{"key":"2_CR85","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/S0006-3495(96)79401-8","volume":"71","author":"JK Myers","year":"1996","unstructured":"Myers, J. K., & Pace, C. N. (1996). Hydrogen bonding stabilizes globular proteins. Biophysical Journal, 71, 2033\u20132039.","journal-title":"Biophysical Journal"},{"key":"2_CR86","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/jmbi.1996.0712","volume":"265","author":"D Xu","year":"1997","unstructured":"Xu, D., Lin, S. L., & Nussinov, R. (1997). Protein binding versus protein folding: The role of hydrophilic bridges in protein associations. Journal of Molecular Biology, 265, 68\u201384.","journal-title":"Journal of Molecular Biology"},{"issue":"12","key":"2_CR87","doi-asserted-by":"crossref","first-page":"e14217","DOI":"10.1371\/journal.pone.0014217","volume":"5","author":"S Mohan","year":"2010","unstructured":"Mohan, S., Sheena, A., Poulose, N., & Anilkumar, G. (2010). Molecular dynamics simulation studies of GLUT4: Substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibition. PLoS One, 5(12), e14217. doi: 10.1371\/journal.pone.0014217 .","journal-title":"PLoS One"},{"key":"2_CR88","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/nar\/gkm423","volume":"35","author":"KG Tina","year":"2007","unstructured":"Tina, K. G., Bhadra, R., & Srinivasan, N. (2007). PIC: Protein Interactions Calculator. Nucleic Acids Research, 35, 473\u2013476.","journal-title":"Nucleic Acids Research"},{"key":"2_CR89","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0022-2836(73)90011-9","volume":"79","author":"A Shrake","year":"1997","unstructured":"Shrake, A., & Rupley, J. A. (1997). Environment and exposure to solvent of protein atoms. Lysozyme and insulin. Journal of Molecular Biology, 79, 351\u2013371.","journal-title":"Journal of Molecular Biology"},{"key":"2_CR90","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/jmbi.1997.1237","volume":"272","author":"D Gilis","year":"1997","unstructured":"Gilis, D., & Rooman, M. (1997). Predicting protein stability changes upon mutation using database-derived potentials: Solvent accessibility determines the importance of local versus non-local interactions along the sequence. Journal of Molecular Biology, 272, 276\u2013290.","journal-title":"Journal of Molecular Biology"},{"issue":"1","key":"2_CR91","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0263-7855(90)80070-V","volume":"8","author":"G Vriend","year":"1990","unstructured":"Vriend, G. (1990). WHAT IF: A molecular modeling and drug design program. Journal of Molecular Graphics, 8(1), 52\u201356.","journal-title":"Journal of Molecular Graphics"},{"key":"2_CR92","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ng.462","volume":"41","author":"JC Chambers","year":"2009","unstructured":"Chambers, J. C., Zhang, W., Li, Y., Sehmi, J., Wass, M. N., Zabaneh, D., et al. (2009). Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature Genetics, 41, 1170\u20131172.","journal-title":"Nature Genetics"},{"key":"2_CR93","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.2217\/pgs.11.109","volume":"12","author":"E Giovannetti","year":"2011","unstructured":"Giovannetti, E., Pacetti, P., Reni, M., Leon, L. G., Mambrini, A., et al. (2011). Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy. Pharmacogenomics, 12, 1641\u20131652.","journal-title":"Pharmacogenomics"},{"key":"2_CR94","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/humu.22","volume":"17","author":"Z Wang","year":"2001","unstructured":"Wang, Z., & Moult, J. (2001). SNPs, protein structure, and disease. Human Mutation, 17, 263\u2013270.","journal-title":"Human Mutation"},{"key":"2_CR95","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbapap.2007.04.014","volume":"1774","author":"W-T Hsu","year":"2007","unstructured":"Hsu, W.-T., Pang, C. N., Sheetal, J., & Wilkins, M. R. (2007). Protein\u2013protein interactions and disease: Use of S. cerevisiae as a model system. Biochimica et Biophysica Acta, 1774, 838\u2013847.","journal-title":"Biochimica et Biophysica Acta"},{"key":"2_CR96","first-page":"1173","volume":"11","author":"RR Brent","year":"1995","unstructured":"Brent, R. R. (1995). p16 proteins from melanoma-prone families are deficient in binding to Cdk4. Oncogene, 11, 1173\u20131178.","journal-title":"Oncogene"},{"key":"2_CR97","first-page":"6026","volume":"62","author":"X Sun","year":"2002","unstructured":"Sun, X., Zheng, L., & Shen, B. (2002). Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome. Cancer Research, 62, 6026\u20136030.","journal-title":"Cancer Research"},{"key":"2_CR98","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/hmg\/7.9.1475","volume":"7","author":"J Anderson","year":"1998","unstructured":"Anderson, J., Burns, H. D., Harris, P. E., Wilkie, A. O. M., & Heath, J. K. (1998). Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Human Molecular Genetics, 7, 1475\u20131483.","journal-title":"Human Molecular Genetics"},{"key":"2_CR99","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1210\/mend.15.1.0581","volume":"15","author":"G Buchanan","year":"2001","unstructured":"Buchanan, G., Yang, M., Harris, J. M., Nahm, H. S., Han, G., et al. (2001). Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function. Molecular Endocrinology, 15, 46\u201356.","journal-title":"Molecular Endocrinology"},{"key":"2_CR100","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0047-6374(03)00164-7","volume":"124","author":"JC Shen","year":"2003","unstructured":"Shen, J. C., Lao, Y., Kamath-Loeb, A., Wold, M. S., & Loe, L. A. (2003). The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity. Mechanisms of Ageing and Development, 124, 921\u2013930.","journal-title":"Mechanisms of Ageing and Development"},{"key":"2_CR101","volume-title":"The PyMOL molecular graphics system, Version 0.99","author":"WL DeLano","year":"2002","unstructured":"DeLano, W. L. (2002). The PyMOL molecular graphics system, Version 0.99. San Carlos, CA: DeLano Scientific."},{"key":"2_CR102","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature01230","volume":"420","author":"L Pellegrini","year":"2002","unstructured":"Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., et al. (2002). Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature, 420, 287\u2013293.","journal-title":"Nature"},{"key":"2_CR103","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.febslet.2011.05.027","volume":"585","author":"K Ochiai","year":"2011","unstructured":"Ochiai, K., Yoshikawa, Y., Yoshimatsu, K., Oonuma, T., Tomioka, Y., et al. (2011). Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51. FEBS Letters, 585, 1771\u20131777.","journal-title":"FEBS Letters"},{"key":"2_CR104","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/157016409789973734","volume":"6","author":"J Chen","year":"2009","unstructured":"Chen, J., & Shen, B. (2009). Computational analysis of amino acid mutation: A proteome wide perspective. Current Proteomics, 6, 4.","journal-title":"Current Proteomics"},{"key":"2_CR105","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.abb.2007.02.020","volume":"461","author":"Z Bikadi","year":"2007","unstructured":"Bikadi, Z., Demko, L., & Hazai, E. (2007). Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot. Archives of Biochemistry and Biophysics, 461, 225\u2013234.","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"2_CR106","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0168-9525(03)00195-1","volume":"19","author":"RE Steward","year":"2003","unstructured":"Steward, R. E., MacArthur, M. W., Laskowski, R. A., et al. (2003). Molecular basis of inherited diseases: A structural perspective. Trends in Genetics, 19, 505\u2013513.","journal-title":"Trends in Genetics"},{"key":"2_CR107","first-page":"439","volume":"4","author":"Y Ye","year":"2006","unstructured":"Ye, Y., Li, Z., & Godzik, A. (2006). Modeling and analyzing threedimensional structures of human disease proteins. Pacific Symposium on Biocomputing, 4, 439\u2013450.","journal-title":"Pacific Symposium on Biocomputing"},{"key":"2_CR108","first-page":"3812","volume":"13","author":"PC Ng","year":"2003","unstructured":"Ng, P. C., & Henikoff, S. (2003). SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Research, 13, 3812\u20133814.","journal-title":"Nucleic Acids Research"},{"key":"2_CR109","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1101\/gr.176601","volume":"11","author":"PC Ng","year":"2001","unstructured":"Ng, P. C., & Henikoff, S. (2001). SIFT: Predicting deleterious amino acid changes that affect protein function. Genome Research, 11, 863\u2013874.","journal-title":"Genome Research"},{"key":"2_CR110","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1471-2105-7-217","volume":"7","author":"RJ Dobson","year":"2006","unstructured":"Dobson, R. J., Munroe, P. B., Caulfield, M. J., & Saqi, M. A. (2006). Predicting deleterious nsSNPs: An analysis of sequence and structural attributes. BMC Bioinformatics, 7, 217.","journal-title":"BMC Bioinformatics"},{"key":"2_CR111","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1093\/bioinformatics\/bti365","volume":"21","author":"L Bao","year":"2005","unstructured":"Bao, L., & Cui, Y. (2005). Prediction of the phenotypic effects of non-synonymous single nucleotide polymorphisms using structural and evolutionary information. Bioinformatics, 21, 2185\u20132190.","journal-title":"Bioinformatics"},{"key":"2_CR112","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/nar\/28.1.374","volume":"28","author":"S Kawashima","year":"2000","unstructured":"Kawashima, S., & Kanehisa, M. (2000). AAindex: Amino acid index database. Nucleic Acids Research, 28, 374.","journal-title":"Nucleic Acids Research"},{"key":"2_CR113","volume-title":"Biomolecular simulation: The GROMOS96 manual and user guide","author":"WF Gunsteren Van","year":"1996","unstructured":"Van Gunsteren, W. F., Billeter, S. R., Eising, A. A., Hunenberger, P. H., Kruger, P., et al. (1996). Biomolecular simulation: The GROMOS96 manual and user guide. Groningen: vdf Hochschulverlag AG an der ETH Zurich and BIOMOS b.v."},{"key":"2_CR114","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"WL Jorgensen","year":"1983","unstructured":"Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., & Klein, M. L. (1983). Comparison of simple potential functions for simulating liquid water. The Journal of Chemical Physics, 79, 926.","journal-title":"The Journal of Chemical Physics"},{"key":"2_CR115","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"HJC Berendsen","year":"1984","unstructured":"Berendsen, H. J. C., Postma, J. P. M., van Gunsteren, W. F., DiNola, A., & Haak, J. R. (1984). Molecular dynamics with coupling to an external bath. The Journal of Chemical Physics, 81, 3684\u20133690.","journal-title":"The Journal of Chemical Physics"},{"key":"2_CR116","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"U Essmann","year":"1995","unstructured":"Essmann, U., Perera, L., Berkowitz, M. L., Darden, T., Lee, H., & Pedersen, L. G. (1995). A smootparticle meshes Ewald method. The Journal of Chemical Physics, 103, 8577\u20138593.","journal-title":"The Journal of Chemical Physics"},{"key":"2_CR117","volume-title":"AMBER simulation software package","author":"DA Case","year":"2002","unstructured":"Case, D. A., Pearlman, D. A., Caldwell, J. W., Wang, J., Ross, W. S., et al. (2002). AMBER simulation software package. San Francisco, CA: University of California."},{"key":"2_CR118","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0079-6107(84)90007-5","volume":"44","author":"EN Baker","year":"1984","unstructured":"Baker, E. N., & Hubbard, R. E. (1984). Hydrogen bonding in globular proteins. Progress in Biophysics and Molecular Biology, 44, 97\u2013179.","journal-title":"Progress in Biophysics and Molecular Biology"},{"key":"2_CR119","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0022-2836(83)80079-5","volume":"168","author":"DJ Barlow","year":"1983","unstructured":"Barlow, D. J., & Thornton, J. M. (1983). Ion-pairs in proteins. Journal of Molecular Biology, 168, 867\u2013885.","journal-title":"Journal of Molecular Biology"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0002-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-014-0002-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0002-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T07:59:01Z","timestamp":1597823941000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-014-0002-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,11]]},"references-count":119,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["2"],"URL":"https:\/\/doi.org\/10.1007\/s12013-014-0002-9","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,11]]}}}