{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:21:36Z","timestamp":1791206496073,"version":"4.1.0"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s12013-014-0006-5","type":"journal-article","created":{"date-parts":[[2014,5,7]],"date-time":"2014-05-07T15:23:31Z","timestamp":1399476211000},"page":"707-719","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Autophagy of Mitochondria: A Promising Therapeutic Target for Neurodegenerative Disease"],"prefix":"10.1007","volume":"70","author":[{"given":"Pradip K.","family":"Kamat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Kalani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kyles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C.","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,8]]},"reference":[{"key":"6_CR1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2741\/2714","volume":"13","author":"JJ Shacka","year":"2008","unstructured":"Shacka, J. J., Roth, K. A., & Zhang, J. (2008). The autophagy\u2013lysosomal degradation pathway: Role in neurodegenerative disease and therapy. Frontiers in Bioscience, 13, 718\u2013736.","journal-title":"Frontiers in Bioscience"},{"key":"6_CR2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2217\/14796708.3.3.309","volume":"3","author":"SJ Cherra 3rd","year":"2008","unstructured":"Cherra, S. J, 3rd, & Chu, C. T. (2008). Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurology, 3, 309\u2013323.","journal-title":"Future Neurology"},{"key":"6_CR3","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1136\/jnnp.74.9.1188","volume":"74","author":"PF Chinnery","year":"2003","unstructured":"Chinnery, P. F., & Schon, E. A. (2003). Mitochondria. Journal of Neurology, Neurosurgery and Psychiatry, 74, 1188\u20131199.","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"6_CR4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00702-009-0240-y","volume":"9","author":"KA Jellinger","year":"2009","unstructured":"Jellinger, K. A. (2009). Recent advances in our understanding of neurodegeneration. Journal of Neural Transmission, 9, 1111\u20131162.","journal-title":"Journal of Neural Transmission"},{"key":"6_CR5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/NMM:4:1-2:21","volume":"4","author":"M Hashimoto","year":"2003","unstructured":"Hashimoto, M., Rockenstein, E., Crews, L., & Masliah, E. (2003). Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer\u2019s and Parkinson\u2019s diseases. NeuroMolecular Medicine, 4, 21\u201336.","journal-title":"NeuroMolecular Medicine"},{"key":"6_CR6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00415-011-6113-y","volume":"259","author":"E Cardaioli","year":"2012","unstructured":"Cardaioli, E., Sicurelli, F., Carluccio, M. A., Gallus, G. N., Da Pozzo, P., Mondelli, M., et al. (2012). A new thymidine phosphorylase mutation causing elongation of the protein underlies mitochondrial neurogastrointestinal encephalomyopathy. Journal of Neurology, 259, 172\u2013174.","journal-title":"Journal of Neurology"},{"key":"6_CR7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pbb.2011.08.019","volume":"100","author":"PK Kamat","year":"2011","unstructured":"Kamat, P. K., Tota, S., Shukla, R., Ali, S., Najmi, A. K., & Nath, C. (2011). Mitochondrial dysfunction: a crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain. Pharmacology, Biochemistry and Behavior, 100, 311\u2013319.","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"6_CR8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10863-005-4128-8","volume":"37","author":"PD Gavin","year":"2005","unstructured":"Gavin, P. D., Prescott, M., & Devenish, R. J. (2005). F1F0-ATP synthase complex interactions in vivo can occur in the absence of the dimer specific subunit. Journal of Bioenergetics and Biomembranes, 37, 55\u201366.","journal-title":"Journal of Bioenergetics and Biomembranes"},{"key":"6_CR9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.abb.2007.03.034","volume":"462","author":"I Kim","year":"2007","unstructured":"Kim, I., Rodr\u00edguez-Enr\u00edquez, S., & Lemasters, J. J. (2007). Selective degradation of mitochondria by mitophagy. Archives of Biochemistry and Biophysics, 462, 245\u2013253.","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"6_CR10","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3858\/emm.2012.44.2.028","volume":"44","author":"K Jing","year":"2012","unstructured":"Jing, K., & Lim, K. (2012). Why is autophagy important in human diseases? Experimental & Molecular Medicine, 44, 69\u201372.","journal-title":"Experimental & Molecular Medicine"},{"key":"6_CR11","doi-asserted-by":"crossref","first-page":"C203","DOI":"10.1152\/ajpcell.00097.2010","volume":"299","author":"RA Gottlieb","year":"2010","unstructured":"Gottlieb, R. A., & Carreira, R. S. (2010). Autophagy in health and disease. American Journal of Physiology - Cell Physiology, 299, C203\u2013C210.","journal-title":"American Journal of Physiology - Cell Physiology"},{"key":"6_CR12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","volume":"441","author":"M Komatsu","year":"2006","unstructured":"Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J. I., Tanida, I., et al. (2006). Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature, 441, 880\u2013884.","journal-title":"Nature"},{"key":"6_CR13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.tins.2010.09.001","volume":"33","author":"R Banerjee","year":"2010","unstructured":"Banerjee, R., Beal, M. F., & Thomas, B. (2010). Autophagy in neurodegenerative disorders: Pathogenic roles and therapeutic implications. Trends in Neuroscience, 33, 541\u2013549.","journal-title":"Trends in Neuroscience"},{"key":"6_CR14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn.2575","volume":"13","author":"E Wong","year":"2010","unstructured":"Wong, E., & Cuervo, A. M. (2010). Autophagy gone awry in neurodegenerative diseases. Nature Neuroscience, 13, 805\u2013811.","journal-title":"Nature Neuroscience"},{"key":"6_CR15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1586\/ern.10.84","volume":"10","author":"PI Moreira","year":"2010","unstructured":"Moreira, P. I., Santos, R. X., Zhu, X., Lee, H. G., Smith, M. A., Casadesus, G., et al. (2010). Autophagy in Alzheimer\u2019s disease. Expert Review of Neurotherapeutics, 10, 1209\u20131218.","journal-title":"Expert Review of Neurotherapeutics"},{"key":"6_CR16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1745-7254.2005.00235.x","volume":"26","author":"YP Yang","year":"2005","unstructured":"Yang, Y. P., Liang, Z. Q., Gu, Z. L., & Qin, Z. H. (2005). Molecular mechanism and regulation of autophagy. Acta Pharmacologica Sinica, 26, 1421\u20131434.","journal-title":"Acta Pharmacologica Sinica"},{"key":"6_CR17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/hmg\/ddg109","volume":"12","author":"B Ravikumar","year":"2003","unstructured":"Ravikumar, B., Stewart, A., Kita, H., Kato, K., Duden, R., & Rubinsztein, D. C. (2003). Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Human Molecular Genetics, 12, 985\u2013994.","journal-title":"Human Molecular Genetics"},{"key":"6_CR18","doi-asserted-by":"crossref","first-page":"25009","DOI":"10.1074\/jbc.M300227200","volume":"278","author":"JL Webb","year":"2003","unstructured":"Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., & Rubinsztein, D. C. (2003). Alpha-Synuclein is degraded by both autophagy and the proteasome. Journal of Biological Chemistry, 278, 25009\u201325013.","journal-title":"Journal of Biological Chemistry"},{"key":"6_CR19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.canlet.2008.09.042","volume":"275","author":"B Liu","year":"2009","unstructured":"Liu, B., Cheng, Y., Zhang, B., Bian, H. J., & Bao, J. K. (2009). Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Letters, 275, 54\u201360.","journal-title":"Cancer Letters"},{"key":"6_CR20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0076-6879(08)04011-1","volume":"453","author":"CT Chu","year":"2009","unstructured":"Chu, C. T., Plowey, E. D., Dagda, R. K., Hickey, R. W., Cherra, S. J, 3rd, & Clark, R. S. (2009). Autophagy in neurite injury and neurodegeneration: In vitro and in vivo models. Methods in Enzymology, 453, 217\u2013249.","journal-title":"Methods in Enzymology"},{"key":"6_CR21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/157015908784533897","volume":"6","author":"B Bossy","year":"2008","unstructured":"Bossy, B., Perkins, G., & Bossy-Wetzel, E. (2008). Clearing the brain\u2019s cobwebs: The role of autophagy in neuroprotection. Current Neuropharmacology, 6, 97\u2013101.","journal-title":"Current Neuropharmacology"},{"key":"6_CR22","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s00415-011-6104-z","volume":"258","author":"M Filosto","year":"2011","unstructured":"Filosto, M., Scarpelli, M., Cotelli, M. S., Vielmi, V., Todeschini, A., Gregorelli, V., et al. (2011). The role of mitochondria in neurodegenerative diseases. Journal of Neurology, 258, 1763\u20131774.","journal-title":"Journal of Neurology"},{"key":"6_CR23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00424-012-1079-x","volume":"464","author":"MU Khan","year":"2012","unstructured":"Khan, M. U., Cheema, Y., Shahbaz, A. U., Ahokas, R. A., Sun, Y., Gerling, I. C., et al. (2012). Mitochondria play a central role in nonischemic cardiomyocyte necrosis: Common to acute and chronic stressor states. Pflugers Archiv, 464, 123\u2013131.","journal-title":"Pflugers Archiv"},{"key":"6_CR24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1194\/jlr.M800658-JLR200","volume":"50","author":"YZ Zheng","year":"2009","unstructured":"Zheng, Y. Z., Berg, K. B., & Foster, L. J. (2009). Mitochondria do not contain lipid rafts, and lipid rafts do not contain mitochondrial proteins. Journal of Lipid Research, 50, 988\u2013998.","journal-title":"Journal of Lipid Research"},{"key":"6_CR25","doi-asserted-by":"crossref","first-page":"8791","DOI":"10.1167\/iovs.11-8203","volume":"52","author":"JM Santos","year":"2011","unstructured":"Santos, J. M., & Kowluru, R. A. (2011). Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Investigative Ophthalmology & Visual Science, 52, 8791\u20138798.","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"6_CR26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3410\/B1-17","volume":"1","author":"MJ Parsons","year":"2009","unstructured":"Parsons, M. J., & Green, D. R. (2009). Mitochondria and apoptosis: a quick take on a long view. F1000 Biology Reports, 1, 17.","journal-title":"F1000 Biology Reports"},{"key":"6_CR27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fgene.2012.00297","volume":"3","author":"K Palikaras","year":"2012","unstructured":"Palikaras, K., & Tavernarakis, N. (2012). Mitophagy in neurodegeneration and aging. Frontiers in Genetics, 3, 297.","journal-title":"Frontiers in Genetics"},{"key":"6_CR28","doi-asserted-by":"crossref","first-page":"G274","DOI":"10.1152\/ajpcell.00153.2003","volume":"285","author":"T Hagen","year":"2003","unstructured":"Hagen, T., Lagace, C. J., Modica-Napolitano, J. S., & Aprille, J. R. (2003). Permeability transition in rat liver mitochondria is modulated by the ATP-Mg\/Pi carrier. American Journal of Physiology: Gastrointestinal and Liver Physiology, 285, G274\u2013G281.","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"6_CR29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1101\/sqb.2005.70.035","volume":"70","author":"DC Wallace","year":"2005","unstructured":"Wallace, D. C. (2005). Mitochondria and cancer: Warburg addressed. Cold Spring Harbor Symposia on Quantitative Biology, 70, 363\u2013374.","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"6_CR30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-4419-6706-0_8","volume":"687","author":"M Karbowski","year":"2010","unstructured":"Karbowski, M. (2010). Mitochondria on guard: Role of mitochondrial fusion and fission in the regulation of apoptosis. Advances in Experimental Medicine and Biology, 687, 131\u2013142.","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"6_CR31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/bst0290431","volume":"29","author":"T Langer","year":"2001","unstructured":"Langer, T., Kaser, M., Klanner, C., & Leonhard, K. (2001). AAA proteases of mitochondria: Quality control of membrane proteins and regulatory functions during mitochondrial biogenesis. Biochemical Society Transactions, 29, 431\u2013436.","journal-title":"Biochemical Society Transactions"},{"key":"6_CR32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cub.2011.11.057","volume":"22","author":"V Soubannier","year":"2012","unstructured":"Soubannier, V., McLelland, G. L., Zunino, R., Braschi, E., Rippstein, P., Fon, E. A., et al. (2012). A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Current Biology, 22, 135\u2013141.","journal-title":"Current Biology"},{"key":"6_CR33","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0891-5849(03)00464-7","volume":"35","author":"S Miwa","year":"2003","unstructured":"Miwa, S., St-Pierre, J., Partridge, L., & Brand, M. D. (2003). Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radical Biology & Medicine, 35, 938\u2013948.","journal-title":"Free Radical Biology & Medicine"},{"key":"6_CR34","doi-asserted-by":"crossref","first-page":"C176","DOI":"10.1152\/ajpcell.00348.2005","volume":"291","author":"G Twig","year":"2006","unstructured":"Twig, G., Graf, S. A., Wikstrom, J. D., Mohamed, H., Haigh, S. E., Elorza, A., et al. (2006). Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. American Journal of Physiology Cell Physiology, 291, C176\u2013C184.","journal-title":"American Journal of Physiology Cell Physiology"},{"key":"6_CR35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","volume":"27","author":"G Twig","year":"2008","unstructured":"Twig, G., Elorza, A., Molina, A. J., Mohamed, H., Wikstrom, J. D., Walzer, G., et al. (2008). Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO Journal, 27, 433\u2013446.","journal-title":"EMBO Journal"},{"key":"6_CR36","doi-asserted-by":"crossref","first-page":"43198","DOI":"10.1074\/jbc.M510279200","volume":"280","author":"M Frieden","year":"2005","unstructured":"Frieden, M., Arnaudeau, S., Castelbou, C., & Demaurex, N. (2005). Subplasmalemmal mitochondria modulate the activity of plasma membrane Ca2\u00a0+\u00a0-ATPases. Journal of Biological Chemistry, 280, 43198\u201343208.","journal-title":"Journal of Biological Chemistry"},{"key":"6_CR37","author":"J Gruber","year":"2012","unstructured":"Gruber, J., Fong, S., Chen, C. B., Yoong, S., Pastorin, G., Schaffer, S., et al. (2012). Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnology Advances. doi: 10.1016\/j.biotechadv.2012.09.005 .","journal-title":"Biotechnology Advances"},{"key":"6_CR38","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-006-6715-5","volume":"11","author":"J Chen","year":"2006","unstructured":"Chen, J., Tang, X. Q., Zhi, J. L., Cui, Y., Yu, H. M., Tang, E. H., et al. (2006). Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis, 11, 943\u2013953.","journal-title":"Apoptosis"},{"key":"6_CR39","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1158\/1535-7163.MCT-05-0476","volume":"5","author":"L Tang","year":"2006","unstructured":"Tang, L., Zhang, Y., Jobson, H. E., Li, J., Stephenson, K. K., Wade, K. L., et al. (2006). Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. Molecular Cancer Therapeutics, 5, 935\u2013944.","journal-title":"Molecular Cancer Therapeutics"},{"key":"6_CR40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2005.8.3","volume":"8","author":"JJ Lemasters","year":"2005","unstructured":"Lemasters, J. J. (2005). Selective mitochondrial autophagy, or\u00a0mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Research, 8, 3\u20135.","journal-title":"Rejuvenation Research"},{"key":"6_CR41","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/nm1106-1241","volume":"12","author":"MT Lin","year":"2006","unstructured":"Lin, M. T., & Beal, M. F. (2006). Alzheimer\u2019s APP mangles mitochondria. Nature Medicine, 12, 1241\u20131243.","journal-title":"Nature Medicine"},{"key":"6_CR42","doi-asserted-by":"crossref","first-page":"H2166","DOI":"10.1152\/ajpheart.00780.2011","volume":"302","author":"G Frazziano","year":"2012","unstructured":"Frazziano, G., Champion, H. C., & Pagano, P. J. (2012). NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone. American Journal of Physiology Heart and Circulatory Physiology, 302, H2166\u2013H2177.","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"6_CR43","first-page":"H718","volume":"276","author":"E Takahashi","year":"1999","unstructured":"Takahashi, E., Endoh, H., & Doi, K. (1999). Intracellular gradients of O2 supply to mitochondria in actively respiring single cardiomyocyte of rats. American Journal of Physiology, 276, H718\u2013H724.","journal-title":"American Journal of Physiology"},{"key":"6_CR44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neuint.2011.07.003","volume":"59","author":"MC McKenna","year":"2011","unstructured":"McKenna, M. C. (2011). Glutamate dehydrogenase in brain mitochondria: Do lipid modifications and transient metabolon formation influence enzyme activity? Neurochemistry International, 59, 525\u2013533.","journal-title":"Neurochemistry International"},{"key":"6_CR45","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0891-5849(01)00724-9","volume":"31","author":"J Nordberg","year":"2001","unstructured":"Nordberg, J., & Arner, E. S. (2001). Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radical Biology & Medicine, 31, 1287\u20131312.","journal-title":"Free Radical Biology & Medicine"},{"key":"6_CR46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","volume":"552","author":"JF Turrens","year":"2003","unstructured":"Turrens, J. F. (2003). Mitochondrial formation of reactive oxygen species. Journal of Physiology, 552, 335\u2013344.","journal-title":"Journal of Physiology"},{"key":"6_CR47","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/00002281-200211000-00001","volume":"14","author":"IE Lundberg","year":"2002","unstructured":"Lundberg, I. E. (2002). New possibilities to achieve increased understanding of disease mechanisms in idiopathic inflammatory myopathies. Current Opinion in Rheumatology, 14, 639\u2013642.","journal-title":"Current Opinion in Rheumatology"},{"key":"6_CR48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0014-5793(96)00230-X","volume":"383","author":"RH Burdon","year":"1996","unstructured":"Burdon, R. H., Gill, V., Boyd, P. A., & Rahim, R. A. (1996). Hydrogen peroxide and sequence-specific DNA damage in human cells. FEBS Letters, 383, 150\u2013154.","journal-title":"FEBS Letters"},{"key":"6_CR49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4161\/auto.1.1.1513","volume":"1","author":"DC Rubinsztein","year":"2005","unstructured":"Rubinsztein, D. C., DiFiglia, M., Heintz, N., Nixon, R. A., Qin, Z. H., Ravikumar, B., et al. (2005). Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy, 1, 11\u201322.","journal-title":"Autophagy"},{"key":"6_CR50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2665","volume":"10","author":"L Galluzzi","year":"2009","unstructured":"Galluzzi, L., Blomgren, K., & Kroemer, G. (2009). Mitochondrial membrane permeabilization in neuronal injury. Nature Reviews Neuroscience, 10, 481\u2013494.","journal-title":"Nature Reviews Neuroscience"},{"key":"6_CR51","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1038\/onc.2008.308","volume":"27","author":"P Pinton","year":"2008","unstructured":"Pinton, P., Giorgi, C., Siviero, R., Zecchini, E., & Rizzuto, R. (2008). Calcium and apoptosis: ER-mitochondria Ca2\u00a0+\u00a0transfer in the control of apoptosis. Oncogene, 27, 6407\u20136418.","journal-title":"Oncogene"},{"key":"6_CR52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jcb.22080","volume":"107","author":"V Zecchini","year":"2009","unstructured":"Zecchini, V., & Mills, I. G. (2009). Putting chromatin immunoprecipitation into context. Journal of Cellular Biochemistry, 107, 19\u201329.","journal-title":"Journal of Cellular Biochemistry"},{"key":"6_CR53","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1527-3458.2003.tb00254.x","volume":"9","author":"MA Rogawski","year":"2003","unstructured":"Rogawski, M. A., & Wenk, G. L. (2003). The neuropharmacological basis for the use of memantine in the treatment of Alzheimer\u2019s disease. CNS Drug Reviews, 9, 275\u2013308.","journal-title":"CNS Drug Reviews"},{"key":"6_CR54","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1471-4159.2004.02438.x","volume":"89","author":"SM Cardoso","year":"2004","unstructured":"Cardoso, S. M., Santana, I., Swerdlow, R. H., & Oliveira, C. R. (2004). Mitochondria dysfunction of Alzheimer\u2019s disease cybrids enhances Abeta toxicity. Journal of Neurochemistry, 89, 1417\u20131426.","journal-title":"Journal of Neurochemistry"},{"key":"6_CR55","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0891-5849(02)00794-3","volume":"32","author":"DA Butterfield","year":"2002","unstructured":"Butterfield, D. A., & Lauderback, C. M. (2002). Lipid peroxidation and protein oxidation in Alzheimer\u2019s disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radical Biology & Medicine, 32, 1050\u20131060.","journal-title":"Free Radical Biology & Medicine"},{"key":"6_CR56","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0306-4522(00)00580-7","volume":"103","author":"MY Aksenov","year":"2000","unstructured":"Aksenov, M. Y., Aksenova, M. V., Butterfield, D. A., Geddes, J. W., & Markesbery, W. R. (2000). Protein oxidation in the brain in Alzheimer\u2019s disease. Neuroscience, 103, 373\u2013383.","journal-title":"Neuroscience"},{"key":"6_CR57","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pnpbp.2010.07.004","volume":"35","author":"A Maruszak","year":"2011","unstructured":"Maruszak, A., & Zekanowski, C. (2011). Mitochondrial dysfunction and Alzheimer\u2019s disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35, 320\u2013330.","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"6_CR58","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4161\/auto.2729","volume":"2","author":"D Butler","year":"2006","unstructured":"Butler, D., Nixon, R. A., & Bahr, B. A. (2006). Potential compensatory responses through autophagic\/lysosomal pathways in neurodegenerative diseases. Autophagy, 2, 234\u2013237.","journal-title":"Autophagy"},{"key":"6_CR59","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jnen\/64.2.113","volume":"64","author":"RA Nixon","year":"2005","unstructured":"Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., et al. (2005). Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Neuropathology & Experimental Neurology, 64, 113\u2013122.","journal-title":"Neuropathology & Experimental Neurology"},{"key":"6_CR60","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1242\/jcs.019265","volume":"120","author":"RA Nixon","year":"2007","unstructured":"Nixon, R. A. (2007). Autophagy, amyloidogenesis and Alzheimer disease. Journal of Cell Science, 120, 4081\u20134091.","journal-title":"Journal of Cell Science"},{"key":"6_CR61","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1523\/JNEUROSCI.22-07-02780.2002","volume":"22","author":"D Kirik","year":"2002","unstructured":"Kirik, D., Rosenblad, C., Burger, C., Lundberg, C., Johansen, T. E., Muzyczka, N., et al. (2002). Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. Journal of Neuroscience, 22, 2780\u20132791.","journal-title":"Journal of Neuroscience"},{"key":"6_CR62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1742-2094-9-155","volume":"9","author":"L Tian","year":"2012","unstructured":"Tian, L., Ma, L., Kaarela, T., & Li, Z. (2012). Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases. Journal of Neuroinflammation, 9, 155.","journal-title":"Journal of Neuroinflammation"},{"key":"6_CR63","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jns.2007.10.012","volume":"267","author":"C Battisti","year":"2008","unstructured":"Battisti, C., Formichi, P., Radi, E., & Federico, A. (2008). Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation. Journal of the Neurological Sciences, 267, 120\u2013124.","journal-title":"Journal of the Neurological Sciences"},{"key":"6_CR64","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/archneurol.2010.198","volume":"67","author":"L Alvarez-Erviti","year":"2010","unstructured":"Alvarez-Erviti, L., Rodriguez-Oroz, M. C., Cooper, J. M., Caballero, C., Ferrer, I., Obeso, J. A., et al. (2010). Chaperone-mediated autophagy markers in Parkinson disease brains. Archives of Neurology, 67, 1464\u20131472.","journal-title":"Archives of Neurology"},{"key":"6_CR65","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1001\/archneur.61.12.1898","volume":"61","author":"E Rogaeva","year":"2004","unstructured":"Rogaeva, E., Johnson, J., Lang, A. E., Gulick, C., Gwinn-Hardy, K., Kawarai, T., et al. (2004). Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Archives of Neurology, 61, 1898\u20131904.","journal-title":"Archives of Neurology"},{"key":"6_CR66","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11596-006-0430-x","volume":"26","author":"L Yang","year":"2006","unstructured":"Yang, L., Xia, Y., Zhao, H., Zhao, J., & Zhu, X. (2006). Magnetic resonance imaging of transplanted neural stem cells in Parkinson disease rats. Journal of Huazhong University of Science and Technology (Medical Sciences), 26, 489\u2013492.","journal-title":"Journal of Huazhong University of Science and Technology (Medical Sciences)"},{"key":"6_CR67","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bbadis.2008.11.007","volume":"7","author":"R Banerjee","year":"2009","unstructured":"Banerjee, R., Starkov, A. A., Beal, M. F., & Thomas, B. (2009). Mitochondrial dysfunction in the limelight of Parkinson\u2019s disease pathogenesis. Biochimica et Biophysica Acta, 7, 651\u2013663.","journal-title":"Biochimica et Biophysica Acta"},{"key":"6_CR68","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra, D., Tanaka, A., Suen, D. F., & Youle, R. J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. Journal of Cell Biology, 183, 795\u2013803.","journal-title":"Journal of Cell Biology"},{"key":"6_CR69","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4161\/auto.4625","volume":"3","author":"CT Chu","year":"2007","unstructured":"Chu, C. T., Zhu, J., & Dagda, R. (2007). Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: Implications for neurodegeneration and cell death. Autophagy, 3, 663\u2013666.","journal-title":"Autophagy"},{"key":"6_CR70","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","volume":"284","author":"RK Dagda","year":"2009","unstructured":"Dagda, R. K., Cherra, S. J, 3rd, Kulich, S. M., Tandon, A., Park, D., & Chu, C. T. (2009). Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. Journal of Biological Chemistry, 284, 13843\u201313855.","journal-title":"Journal of Biological Chemistry"},{"key":"6_CR71","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1083\/jcb.200810184","volume":"183","author":"HM McBride","year":"2008","unstructured":"McBride, H. M. (2008). Parkin mitochondria in the autophagosome. Journal of Cell Biology, 183, 757\u2013759.","journal-title":"Journal of Cell Biology"},{"key":"6_CR72","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/15216540152845939","volume":"52","author":"JT Greenamyre","year":"2001","unstructured":"Greenamyre, J. T., Sherer, T. B., Betarbet, R., & Panov, A. V. (2001). Complex I and Parkinson\u2019s disease. IUBMB Life, 52, 135\u2013141.","journal-title":"IUBMB Life"},{"key":"6_CR73","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.freeradbiomed.2009.11.026","volume":"48","author":"RC Seet","year":"2010","unstructured":"Seet, R. C., Lee, C. Y., Lim, E. C., Tan, J. J., Quek, A. M., Chong, W. L., et al. (2010). Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. Free Radical Biology & Medicine, 48, 560\u2013566.","journal-title":"Free Radical Biology & Medicine"},{"key":"6_CR74","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","volume":"38","author":"A Bender","year":"2006","unstructured":"Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., et al. (2006). High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nature Genetics, 38, 515\u2013517.","journal-title":"Nature Genetics"},{"key":"6_CR75","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2005.01.034","volume":"380","author":"E Dalfo","year":"2005","unstructured":"Dalfo, E., & Ferrer, I. (2005). Alpha-synuclein binding to rab3a in multiple system atrophy. Neuroscience Letters, 380, 170\u2013175.","journal-title":"Neuroscience Letters"},{"key":"6_CR76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2009.03.003","volume":"640","author":"BM Murphy","year":"2009","unstructured":"Murphy, B. M., Dandy, D. S., & Henry, C. S. (2009). Analysis of oxidative stress biomarkers using a simultaneous competitive\/non-competitive micromosaic immunoassay. Analytica Chimica Acta, 640, 1\u20136.","journal-title":"Analytica Chimica Acta"},{"key":"6_CR77","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1196\/annals.1397.043","volume":"1095","author":"CY Chen","year":"2007","unstructured":"Chen, C. Y., Jang, J. H., Park, M. H., Hwang, S. J., Surh, Y. J., & Park, O. J. (2007). Attenuation of Abeta-induced apoptosis of plant extract (Saengshik) mediated by the inhibition of mitochondrial dysfunction and antioxidative effect. Annals of the New York Academy of Sciences, 1095, 399\u2013411.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"6_CR78","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.conb.2007.04.010","volume":"17","author":"MW Dodson","year":"2007","unstructured":"Dodson, M. W., & Guo, M. (2007). Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson\u2019s disease. Current Opinion in Neurobiology, 17, 331\u2013337.","journal-title":"Current Opinion in Neurobiology"},{"key":"6_CR79","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1212\/01.wnl.0000222734.56412.17","volume":"66","author":"N Pavese","year":"2006","unstructured":"Pavese, N., Gerhard, A., Tai, Y. F., Ho, A. K., Turkheimer, F., Barker, R. A., et al. (2006). Microglial activation correlates with severity in Huntington disease: A clinical and PET study. Neurology, 66, 1638\u20131643.","journal-title":"Neurology"},{"key":"6_CR80","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/0959-4388(95)80072-7","volume":"5","author":"JF Gusella","year":"1995","unstructured":"Gusella, J. F., & MacDonald, M. E. (1995). Huntington\u2019s disease: CAG genetics expands neurobiology. Current Opinion in Neurobiology, 5, 656\u2013662.","journal-title":"Current Opinion in Neurobiology"},{"key":"6_CR81","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1523\/JNEUROSCI.20-19-07268.2000","volume":"20","author":"KB Kegel","year":"2000","unstructured":"Kegel, K. B., Kim, M., Sapp, E., McIntyre, C., Castano, J. G., Aronin, N., et al. (2000). Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. Journal of Neuroscience, 20, 7268\u20137278.","journal-title":"Journal of Neuroscience"},{"key":"6_CR82","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1523\/JNEUROSCI.0106-08.2008","volume":"28","author":"AL Orr","year":"2008","unstructured":"Orr, A. L., Li, S., Wang, C. E., Li, H., Wang, J., Rong, J., et al. (2008). N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. Journal of Neuroscience, 28, 2783\u20132792.","journal-title":"Journal of Neuroscience"},{"key":"6_CR83","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","volume":"5","author":"AV Panov","year":"2002","unstructured":"Panov, A. V., Gutekunst, C. A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., et al. (2002). Early mitochondrial calcium defects in Huntington\u2019s disease are a direct effect of polyglutamines. Nature Neuroscience, 5, 731\u2013736.","journal-title":"Nature Neuroscience"},{"key":"6_CR84","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/S1388-2457(01)00599-5","volume":"112","author":"N Modugno","year":"2001","unstructured":"Modugno, N., Curra, A., Giovannelli, M., Priori, A., Squitieri, F., Ruggieri, S., et al. (2001). The prolonged cortical silent period in patients with Huntington\u2019s disease. Clinical Neurophysiology, 112, 1470\u20131474.","journal-title":"Clinical Neurophysiology"},{"key":"6_CR85","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jns.2008.11.005","volume":"277","author":"YO Herishanu","year":"2009","unstructured":"Herishanu, Y. O., Parvari, R., Pollack, Y., Shelef, I., Marom, B., Martino, T., et al. (2009). Huntington disease in subjects from an Israeli Karaite community carrying alleles of intermediate and expanded CAG repeats in the HTT gene: Huntington disease or phenocopy? Journal of the Neurological Sciences, 277, 143\u2013146.","journal-title":"Journal of the Neurological Sciences"},{"key":"6_CR86","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00005072-197404000-00008","volume":"33","author":"I Tellez-Nagel","year":"1974","unstructured":"Tellez-Nagel, I., Johnson, A. B., & Terry, R. D. (1974). Studies on brain biopsies of patients with Huntington\u2019s chorea. Journal of Neuropathology and Experimental Neurology, 33, 308\u2013332.","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"6_CR87","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1212\/01.wnl.0000307756.15383.fc","volume":"70","author":"M Hirano","year":"2008","unstructured":"Hirano, M. (2008). VAPB: new genetic clues to the pathogenesis of ALS. Neurology, 70, 1161\u20131162.","journal-title":"Neurology"},{"key":"6_CR88","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nn.2528","volume":"13","author":"M Martinez-Vicente","year":"2010","unstructured":"Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., et al. (2010). Cargo recognition failure is responsible for inefficient autophagy in Huntington\u2019s disease. Nature Neuroscience, 13, 567\u2013576.","journal-title":"Nature Neuroscience"},{"key":"6_CR89","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.mad.2010.05.003","volume":"131","author":"H Kawamata","year":"2010","unstructured":"Kawamata, H., & Manfredi, G. (2010). Mitochondrial dysfunction and intracellular calcium dysregulation in ALS. Mechanisms of Ageing and Development, 131, 517\u2013526.","journal-title":"Mechanisms of Ageing and Development"},{"key":"6_CR90","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nn0507-535","volume":"10","author":"JP Julien","year":"2007","unstructured":"Julien, J. P. (2007). ALS: Astrocytes move in as deadly neighbors. Nature Neuroscience, 10, 535\u2013537.","journal-title":"Nature Neuroscience"},{"key":"6_CR91","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbapap.2008.12.008","volume":"1794","author":"B Liu","year":"2009","unstructured":"Liu, B., Tewari, A. K., Zhang, L., Green-Church, K. B., Zweier, J. L., Chen, Y. R., et al. (2009). Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target. Biochimica et Biophysica Acta, 1794, 476\u2013485.","journal-title":"Biochimica et Biophysica Acta"},{"key":"6_CR92","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/S0166-2236(00)01981-0","volume":"24","author":"JS Beckman","year":"2001","unstructured":"Beckman, J. S., Estevez, A. G., Crow, J. P., & Barbeito, L. (2001). Superoxide dismutase and the death of motoneurons in ALS. Trends in Neurosciences, 24, S15\u2013S20.","journal-title":"Trends in Neurosciences"},{"key":"6_CR93","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1440-1789.2009.01088.x","volume":"30","author":"K Okamoto","year":"2010","unstructured":"Okamoto, K., Fujita, Y., & Mizuno, Y. (2010). Pathology of protein synthesis and degradation systems in ALS. Neuropathology, 30, 189\u2013193.","journal-title":"Neuropathology"},{"key":"6_CR94","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1017\/S0317167100008672","volume":"35","author":"B Li","year":"2008","unstructured":"Li, B., Liu, X. Y., Li, Z., Bu, H., Sun, M. M., Guo, Y. S., et al. (2008). Effect of ALS IgG on motor neurons in organotypic spinal cord cultures. Canadian Journal of Neurological Sciences, 35, 220\u2013225.","journal-title":"Canadian Journal of Neurological Sciences"},{"key":"6_CR95","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbadis.2010.05.008","volume":"1802","author":"P Shi","year":"2010","unstructured":"Shi, P., Strom, A. L., Gal, J., & Zhu, H. (2010). Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport. Biochimica et Biophysica Acta, 1802, 707\u2013716.","journal-title":"Biochimica et Biophysica Acta"},{"key":"6_CR96","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","volume":"362","author":"DR Rosen","year":"1993","unstructured":"Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., et al. (1993). Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature, 362, 59\u201362.","journal-title":"Nature"},{"key":"6_CR97","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1212\/01.WNL.0000156155.19270.F8","volume":"64","author":"RH Roxburgh","year":"2005","unstructured":"Roxburgh, R. H., Seaman, S. R., Masterman, T., Hensiek, A. E., Sawcer, S. J., Vukusic, S., et al. (2005). Multiple Sclerosis Severity Score: Using disability and disease duration to rate disease severity. Neurology., 64, 1144\u20131151.","journal-title":"Neurology."},{"key":"6_CR98","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(03)12354-9","volume":"361","author":"J Noseworthy","year":"2003","unstructured":"Noseworthy, J., Kappos, L., & Daumer, M. (2003). Competing interests in multiple sclerosis research. Lancet, 361, 350\u2013351.","journal-title":"Lancet"},{"key":"6_CR99","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/ana.21361","volume":"63","author":"SG Waxman","year":"2008","unstructured":"Waxman, S. G. (2008). Axonal dysfunction in chronic multiple sclerosis: Meltdown in the membrane. Annals of Neurology, 63, 411\u2013413.","journal-title":"Annals of Neurology"},{"key":"6_CR100","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/brain\/awn105","volume":"131","author":"D Mahad","year":"2008","unstructured":"Mahad, D., Ziabreva, I., Lassmann, H., & Turnbull, D. (2008). Mitochondrial defects in acute multiple sclerosis lesions. Brain, 131, 1722\u20131735.","journal-title":"Brain"},{"key":"6_CR101","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/ana.21381","volume":"63","author":"EA Young","year":"2008","unstructured":"Young, E. A., Fowler, C. D., Kidd, G. J., Chang, A., Rudick, R., Fisher, E., et al. (2008). Imaging correlates of decreased axonal Na\u00a0+\/K\u00a0+\u00a0ATPase in chronic multiple sclerosis lesions. Annals of Neurology, 63, 428\u2013435.","journal-title":"Annals of Neurology"},{"key":"6_CR102","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.freeradbiomed.2011.03.027","volume":"51","author":"A Neymotin","year":"2011","unstructured":"Neymotin, A., Calingasan, N. Y., Wille, E., Naseri, N., Petri, S., Damiano, M., et al. (2011). Neuroprotective effect of Nrf2\/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology & Medicine, 51, 88\u201396.","journal-title":"Free Radical Biology & Medicine"},{"key":"6_CR103","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2010.03.017","volume":"49","author":"C Stack","year":"2010","unstructured":"Stack, C., Ho, D., Wille, E., Calingasan, N. Y., Williams, C., Liby, K., et al. (2010). Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington\u2019s disease. Free Radical Biology and Medicine, 49, 147\u2013158.","journal-title":"Free Radical Biology and Medicine"},{"key":"6_CR104","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.expneurol.2010.10.003","volume":"227","author":"A Sauerbeck","year":"2011","unstructured":"Sauerbeck, A., Gao, J., Readnower, R., Liu, M., Pauly, J. R., Bing, G., et al. (2011). Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. Experimental Neurology, 227, 128\u2013135.","journal-title":"Experimental Neurology"},{"key":"6_CR105","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1124\/mol.106.033845","volume":"71","author":"S Ghosh","year":"2007","unstructured":"Ghosh, S., Patel, N., Rahn, D., McAllister, J., Sadeghi, S., Horwitz, G., et al. (2007). The thiazolidinedione pioglitazone alters mitochondrial function in human neuron-like cells. Molecular Pharmacology, 71, 1695\u20131702.","journal-title":"Molecular Pharmacology"},{"key":"6_CR106","doi-asserted-by":"crossref","first-page":"25628","DOI":"10.1074\/jbc.M804291200","volume":"283","author":"RA Quintanilla","year":"2008","unstructured":"Quintanilla, R. A., Jin, Y. N., Fuenzalida, K., Bronfman, M., & Johnson, G. V. (2008). Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease. Journal of Biological Chemistry, 283, 25628\u201325637.","journal-title":"Journal of Biological Chemistry"},{"key":"6_CR107","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12035-010-8111-y","volume":"41","author":"Y Sun Albert","year":"2010","unstructured":"Albert, Y. Sun. (2010). Resveratrol as a therapeutic agent for neurodegenerative diseases. Molecular Neurobiology, 41, 375\u2013383.","journal-title":"Molecular Neurobiology"},{"key":"6_CR108","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1742-2094-2-21","volume":"2","author":"KR Ayasolla","year":"2005","unstructured":"Ayasolla, K. R., Giri, S., Singh, A. K., & Singh, I. (2005). 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and A\u03b2 peptide-induced inflammatory mediators in astroglia. Journal of Neuroinflammation, 2, 21.","journal-title":"Journal of Neuroinflammation"},{"key":"6_CR109","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.2174\/092986711796957257","volume":"18","author":"D Orsucci","year":"2011","unstructured":"Orsucci, D., Mancuso, M., Ienco, E. C., LoGerfo, A., & Siciliano, G. (2011). Targeting mitochondrial dysfunction and neurodegeneration by means of coenzyme Q10 and its analogues. Current Medicinal Chemistry, 18, 4053\u20134064.","journal-title":"Current Medicinal Chemistry"},{"key":"6_CR110","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/ph203134","volume":"2","author":"Mancuso Michelangelo","year":"2009","unstructured":"Michelangelo, Mancuso, Daniele, Orsucci, Valeria, Calsolaro, Anna, Choub, & Gabriele, Siciliano. (2009). Coenzyme Q10 and neurological diseases. Pharmaceuticals, 2, 134\u2013149.","journal-title":"Pharmaceuticals"},{"key":"6_CR111","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.mito.2011.09.006","volume":"12","author":"N Noe","year":"2012","unstructured":"Noe, N., Dillon, L., Lellek, V., Diaz, F., Hida, A., Moraes, C. T., et al. (2012). Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy. Mitochondrion, 12, 258\u2013259.","journal-title":"Mitochondrion"},{"key":"6_CR112","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/hmg\/ddr541","volume":"21","author":"A Johri","year":"2012","unstructured":"Johri, A., Calingasan, N. Y., Hennessey, T. M., Sharma, A., Yang, L., Wille, E., et al. (2012). Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington\u2019s disease. Human Molecular Genetics, 21, 1124\u20131137.","journal-title":"Human Molecular Genetics"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0006-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-014-0006-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0006-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T06:22:42Z","timestamp":1648966962000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-014-0006-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,8]]},"references-count":112,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["6"],"URL":"https:\/\/doi.org\/10.1007\/s12013-014-0006-5","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,8]]}}}