{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:11:24Z","timestamp":1761919884539},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s12013-014-0199-7","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T15:21:29Z","timestamp":1408634489000},"page":"307-314","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is rs8099917 Polymorphism of IL-28B Gene a Good Predictor of Response to Therapy of HCV than rs12979860? An Egyptian Study"],"prefix":"10.1007","volume":"71","author":[{"given":"Olfat","family":"Shaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Rashad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada Abd El","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maissa El","family":"Raziky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"199_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/S1473-3099(05)70216-4","volume":"5","author":"CW Shepard","year":"2005","unstructured":"Shepard, C. W., Finelli, L., & Alter, M. J. (2005). Global epidemiology of hepatitis C virus infection. The Lancet Infectious Diseases,\n                  5, 558\u2013567.","journal-title":"The Lancet Infectious Diseases"},{"key":"199_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/0003-4819-148-1-200801010-00002","volume":"148","author":"JH Jou","year":"2008","unstructured":"Jou, J. H., & Muir, A. J. (2008). In the clinic. Hepatitis C. Annals of Internal Medicine,\n                  148, 1\u201316.","journal-title":"Annals of Internal Medicine"},{"key":"199_CR3","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1002\/hep.22127","volume":"47","author":"SM Kamal","year":"2008","unstructured":"Kamal, S. M., & Naser, L. A. (2008). Hepatitis C genotype4: what we know what we don\u2019t yet know. Hepatology,\n                  47, 1371\u20131383.","journal-title":"Hepatology"},{"issue":"13","key":"199_CR4","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1056\/NEJMoa020047","volume":"347","author":"MW Fried","year":"2002","unstructured":"Fried, M. W., Shiffman, M. L., & Reddy, K. R. (2002). Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. New England Journal of Medicine,\n                  347(13), 975\u2013982.","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"199_CR5","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1002\/hep.20119","volume":"39","author":"DB Strader","year":"2004","unstructured":"Strader, D. B., Wright, T., Thomas, D. L., & Seeff, L. B. (2004). American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C. Hepatology,\n                  39(4), 1147\u20131171.","journal-title":"Hepatology"},{"key":"199_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nri1573","volume":"5","author":"B Rehermann","year":"2005","unstructured":"Rehermann, B., & Nascimbeni, M. (2005). Immunology of hepatitis B virus and hepatitis C virus infection. Nature Reviews Immunology,\n                  5, 215\u2013229.","journal-title":"Nature Reviews Immunology"},{"key":"199_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","volume":"202","author":"S Pestka","year":"2004","unstructured":"Pestka, S., Krause, C. D., & Walter, M. R. (2004). Interferons, interferon-like cytokines, and their receptors. Immunological Reviews,\n                  202, 8\u201332.","journal-title":"Immunological Reviews"},{"key":"199_CR8","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1053\/j.gastro.2009.12.056","volume":"138","author":"A Rauch","year":"2010","unstructured":"Rauch, A., Kutalik, Z., & Descombes, P. (2010). Genetic variation in IL28B isassociated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology,\n                  138, 1338\u20131348.","journal-title":"Gastroenterology"},{"key":"199_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1089\/jir.2005.25.271","volume":"25","author":"A Houldsworth","year":"2005","unstructured":"Houldsworth, A., Metzner, M., Rossol, S., Shaw, S., Kaminiski, E., Demaine, A. C., et al. (2005). Polymorphism in the IL12B gene and outcome of HCV infection. Journal of Interferon and Cytokine Research,\n                  25, 271\u2013276.","journal-title":"Journal of Interferon and Cytokine Research"},{"key":"199_CR10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nature08309","volume":"461","author":"D Ge","year":"2009","unstructured":"Ge, D., Fellay, J., & Thompson, A. J. (2009). Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature,\n                  461, 399\u2013401.","journal-title":"Nature"},{"key":"199_CR11","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","volume":"22","author":"K Ishak","year":"1995","unstructured":"Ishak, K., Baptista, A., & Bianchi, L. (1995). Histological grading and staging of chronic hepatitis. Journal of Hepatology,\n                  22, 696\u2013699.","journal-title":"Journal of Hepatology"},{"key":"199_CR12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/hep.24052","volume":"53","author":"NH Afdhal","year":"2011","unstructured":"Afdhal, N. H., McHutchison, J. G., Zeuzem, S., Mangia, A., Pawlotsky, J. M., Murray, J. S., et al. (2011). Hepatitis C pharmacogenetics. Hepatology,\n                  53, 336\u2013345.","journal-title":"Hepatology"},{"issue":"9","key":"199_CR13","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/infdis\/jir536","volume":"204","author":"F Kurbanov","year":"2011","unstructured":"Kurbanov, F., Abdel-Hamid, M., Latanich, R., Astemborski, J., Mohamed, M., Mikhail, N. M., et al. (2011). Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort. Journal of Infectious Diseases,\n                  204(9), 1391\u20131394.","journal-title":"Journal of Infectious Diseases"},{"issue":"12","key":"199_CR14","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1111\/j.1440-1746.2012.07273.x","volume":"27","author":"OG Shaker","year":"2012","unstructured":"Shaker, O. G., & Sadik, N. A. (2012). Polymorphisms in interleukin-10 and interleukin-28B genes in Egyptian patients with chronic hepatitis C virus genotype 4 and their effect on the response to pegylated interferon\/ribavirin-therapy. Journal of Gastroenterology and Hepatology,\n                  27(12), 1842\u20131849.","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"7","key":"199_CR15","first-page":"e10509","volume":"13","author":"M Khairy","year":"2013","unstructured":"Khairy, M., Fouad, R., Mabrouk, M., El-Akel, W., Awad, A. B., Salama, R., et al. (2013). The impact of interleukin 28b gene polymorphism on the virological response to combined pegylated interferon and ribavirin therapy in chronic HCV genotype 4 infected egyptian patients using data mining analysis. Hepatitis Monthly,\n                  13(7), e10509.","journal-title":"Hepatitis Monthly"},{"issue":"4","key":"199_CR16","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1002\/hep.22759","volume":"49","author":"MG Ghany","year":"2009","unstructured":"Ghany, M. G., Strader, D. B., Thomas, D. L., & Seeff, L. B. (2009). American Association for the Study of Liver Diseases. Diagnosis, management and treatment of hepatitis C. Hepatology,\n                  49(4), 1335\u20131374.","journal-title":"Hepatology"},{"issue":"6","key":"199_CR17","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1056\/NEJMoa0808010","volume":"361","author":"JG McHutchison","year":"2009","unstructured":"McHutchison, J. G., Lawitz, E. J., & Shiffman, M. L. (2009). Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitisC infection. New England Journal of Medicine,\n                  361(6), 580\u2013593.","journal-title":"New England Journal of Medicine"},{"key":"199_CR18","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nature08463","volume":"461","author":"DL Thomas","year":"2009","unstructured":"Thomas, D. L., Thio, C. L., & Martin, M. P. (2009). Genetic variation in IL28B and to spontaneous clearance of hepatitis C virus. Nature,\n                  461, 780\u2013798.","journal-title":"Nature"},{"key":"199_CR19","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1053\/j.gastro.2006.09.052","volume":"131","author":"T Marcello","year":"2006","unstructured":"Marcello, T., Grakoui, A., Barba-Spaeth, G., Machlin, E. S., Kotenko, S. V., MacDonald, M. R., et al. (2006). Interferons \u03b1 and \u03bb inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics. Gastroenterology,\n                  131, 1887\u20131898.","journal-title":"Gastroenterology"},{"key":"199_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/gene.2008.87","volume":"10","author":"C Dellgren","year":"2009","unstructured":"Dellgren, C., Gad, H. H., Hamming, O. J., Melchjorsen, J., & Hartmann, R. (2009). Human interferonlambda3 is a potent member of the type III interferon family. Genes and Immunity,\n                  10, 125\u2013131.","journal-title":"Genes and Immunity"},{"key":"199_CR21","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/ni873","volume":"4","author":"P Sheppard","year":"2003","unstructured":"Sheppard, P., Kindsvogel, W., Xu, W., Henderson, K., Schlutsmeyer, S., Whitmore, T. E., et al. (2003). IL-28, IL-29 and their class II cytokine receptor IL-28R. Nature Immunology,\n                  4, 63\u201368.","journal-title":"Nature Immunology"},{"issue":"1","key":"199_CR22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jhep.2010.10.032","volume":"55","author":"MW Fried","year":"2011","unstructured":"Fried, M. W., Hadziyannis, S. J., Shiffman, M., Messinger, D., & Zeuzem, S. (2011). Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. Journal of Hepatology,\n                  55(1), 69\u201375.","journal-title":"Journal of Hepatology"},{"key":"199_CR23","doi-asserted-by":"publisher","first-page":"e13771","DOI":"10.1371\/journal.pone.0013771","volume":"5","author":"E Aparicio","year":"2010","unstructured":"Aparicio, E., Parera, M., Franco, S., Prez-Alvarez, N., & Tural, C. (2010). IL28B SNP rs8099917 is strongly Associated with pegylated interferon-a and ribavirin therapy treatment failure in HCV\/HIV-1 Coinfected Patients. PLoS ONE,\n                  5, e13771.","journal-title":"PLoS ONE"},{"key":"199_CR24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/hep.23850","volume":"52","author":"J Grebely","year":"2010","unstructured":"Grebely, J., Petoumenos, K., Hellard, M., Matthews, G. V., & Suppiah, V. (2010). Potential role for Interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology,\n                  52, 216\u2013224.","journal-title":"Hepatology"},{"issue":"4","key":"199_CR25","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cgh.2010.07.019","volume":"9","author":"AF St\u00e4ttermayer","year":"2011","unstructured":"St\u00e4ttermayer, A. F., Stauber, R., Hofer, H., Rutter, K., & Beinhardt, S. (2011). Impact of IL28B Genotype on the Early and Sustained Virologic Response in Treatment-naive Patients With Chronic Hepatitis C. Clinical Gastroenterology and Hepatology,\n                  9(4), 344\u2013350.","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"1","key":"199_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/hep.23976","volume":"53","author":"M Yu","year":"2011","unstructured":"Yu, M., Huang, C., Huang, J., Chang, N., Yang, J., Lin, Z., et al. (2011). Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients. Hepatology,\n                  53(1), 7\u201313.","journal-title":"Hepatology"},{"key":"199_CR27","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/ng.447","volume":"41","author":"V Suppiah","year":"2009","unstructured":"Suppiah, V., Moldovan, M., Ahlenstiel, G., Berg, T., Weltman, M., & Abate, M. L. (2009). IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nature Genetics,\n                  41, 1100\u20131104.","journal-title":"Nature Genetics"},{"key":"199_CR28","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/ng.449","volume":"41","author":"Y Tanaka","year":"2009","unstructured":"Tanaka, Y., Nishida, N., Sugiyama, M., Kurosaki, M., Matsuura, K., & Sakamoto, N. (2009). Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic Hepatitis C. Nature Genetics,\n                  41, 1105\u20131109.","journal-title":"Nature Genetics"},{"key":"199_CR29","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1159\/000118791","volume":"51","author":"TS Wang","year":"2008","unstructured":"Wang, T. S., Mo, L. R., Lim, R. T., Kuo, J. J., Chang, K. K., & Wu, J. J. (2008). Artificial neutral net work model is superior to logistic regression model in predicting treatment outcomes of interferon-combination of therapy in patient of chronic hepatitis C. Intervirology,\n                  51, 14\u201320.","journal-title":"Intervirology"},{"key":"199_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.trsl.2006.03.004","volume":"148","author":"S Hosogaya","year":"2006","unstructured":"Hosogaya, S., Ozaki, Y., Enomoto, N., & Akahine, Y. (2006). Analysis of prognostic factors in therapeutic responses to interferon in patients with CHC. Translational Research,\n                  148, 79\u201386.","journal-title":"Translational Research"},{"key":"199_CR31","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/j.1478-3231.2008.01750.x","volume":"28","author":"RR Gad","year":"2008","unstructured":"Gad, R. R., Males, S., El Makhzandy, H., Showman, S., Hassan, A., & Atallah, N. (2008). Predictors of sustained virological response in patients infected with hepatitis C virus genotype4. Liver International,\n                  28, 1112\u20131119.","journal-title":"Liver International"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0199-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-014-0199-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0199-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0199-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:13:35Z","timestamp":1602267215000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-014-0199-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["199"],"URL":"https:\/\/doi.org\/10.1007\/s12013-014-0199-7","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,13]]},"assertion":[{"value":"13 August 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}