{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:44:29Z","timestamp":1782809069500,"version":"3.54.5"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T00:00:00Z","timestamp":1416873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:p>To study the therapeutic effect of Armillarisin A on patients with ulcerative colitis (UC) and on serum IL-1\u03b2 and IL-4, sixty patients with UC were randomly divided into three groups: Armillarisin A treatment group (Group I), Armillarisin-combined hormone therapy group (Group II), and hormones treatment as the control group (Group III). Patients in Group I received Armillarisin A 10\u00a0mg enema in 100\u00a0ml saline. Patients in Group II received Armillarisin A 10\u00a0mg and dexamethasone 5\u00a0mg enema in 100\u00a0ml saline. Patients in Group III received only dexamethasone 5\u00a0mg enema in 100\u00a0ml saline. The therapeutic efficacy and serum levels of IL-4 and IL-1\u03b2 were observed. After 4\u00a0week treatment, the total effective rates were 90.0\u00a0% in Group I and 95.0\u00a0% in Group II. Both are higher than it in control group, which was 70.0\u00a0%. The serum levels of IL-4 in Groups I and II were significantly higher than it in control group. Compared to IL-4 levels before treatment, the levels of IL-4 after treatment were significantly higher in both Groups I and II. The serum levels of IL-11\u03b2 were significantly decreased in Groups I and II in comparison to it in control group. Compared to the levels of IL-1\u03b2 before treatment, the levels of IL-1\u03b2 were significantly decreased. Armillarisin A shows a significant effect in treating UC. It helps increase IL-4 and lower IL-1\u03b2 and the mechanism may be related to the body\u2019s immunity regulation.<\/jats:p>","DOI":"10.1007\/s12013-014-0413-7","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T18:32:23Z","timestamp":1417545143000},"page":"103-106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The Effects of Armillarisin A on Serum IL-1\u03b2 and IL-4 and in Treating Ulcerative Colitis"],"prefix":"10.1007","volume":"72","author":[{"given":"Ping","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,25]]},"reference":[{"issue":"2","key":"413_CR1","first-page":"152","volume":"12","author":"D Sisi","year":"2010","unstructured":"Sisi, D., & Keli, D. (2010). The effects of Yuyang enema regimen in treating ulcerative colitis and on serum IL-4 and IL-10. Liaoning University Traditional Chinese Medicine,\n                  12(2), 152\u2013153.","journal-title":"Liaoning University Traditional Chinese Medicine"},{"issue":"5","key":"413_CR2","first-page":"566","volume":"32","author":"Z Zhijie","year":"2011","unstructured":"Zhijie, Z., Sheng, X., Gaofeng, M., Wenge, Y., & Xinshan, X. (2011). The effect of traditional Chinese medicine in serum IL-8 and IL-10 in ulcerative colitis patients. Shanxi Traditional Chinese Medicine,\n                  32(5), 566\u2013568.","journal-title":"Shanxi Traditional Chinese Medicine"},{"issue":"36","key":"413_CR3","first-page":"34","volume":"49","author":"C Qiangmei","year":"2011","unstructured":"Qiangmei, C. (2011). The study of the mechanism of the effect of sustained release mesalamine granules on serum IL-6 and TNF-\u03b1 in ulcerative colitis patients. Clinical Research,\n                  49(36), 34\u201335.","journal-title":"Clinical Research"},{"key":"413_CR4","unstructured":"Ou, Y., Hu, P., Qian, J., Zheng, J., Hu, R.; Chinese Consensus on Diagnosis and Treatment Standard of Inflammatory Bowel Disease. Inflammatory Bowel Disease Collaborative Group, Chinese Medical Association. (2007). Chinese Journal of Gastroenterology, 12(8), 488\u2013495."},{"issue":"22","key":"413_CR5","first-page":"4742","volume":"21","author":"Lijun Hao","year":"2011","unstructured":"Hao, Lijun, Tang, Wenjun, & Zhang, Rongjuan. (2011). Effect of glutamine granules enema on IFN-y, IL-4, IL-8 in patients with ulcerative colitis and observation of clinical efficacy. Chinese Journal of Nosocomiology,\n                  21(22), 4742\u20134744.","journal-title":"Chinese Journal of Nosocomiology"},{"issue":"1","key":"413_CR6","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1124\/jpet.104.068023","volume":"311","author":"W Cao","year":"2004","unstructured":"Cao, W., Vrees, M. D., Potenti, F. M., Harnett, K. M., Fiocchi, C., & Pricolo, V. E. (2004). Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. Journal of Pharmacology and Experimental Therapeutics,\n                  311(1), 60\u201370.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"7","key":"413_CR7","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/00365520510015629","volume":"40","author":"RD Mittal","year":"2005","unstructured":"Mittal, R. D., Bid, H. K., & Ghoshal, U. C. (2005). IL-1 receptor antagonist (IL-1Ra) gene polymorphism in patients with inflammatory bowel disease in India. Scandinavian Journal of Gastroenterology,\n                  40(7), 827\u2013831.","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"5","key":"413_CR8","first-page":"454","volume":"39","author":"Y Wenjie","year":"2012","unstructured":"Wenjie, Y., Yi, L., Wei, X., Le, D., Xiaoting, L., Weiru, J., et al. (2012). The expression characteristics of IL-2, IL-4, IL-17 and IL-10 and the relationships between these cytokines and the severity of ulcerative colitis. Fudan Xuebao,\n                  39(5), 454\u2013459.","journal-title":"Fudan Xuebao"},{"issue":"6","key":"413_CR9","first-page":"825","volume":"16","author":"S Zhaomin","year":"2011","unstructured":"Zhaomin, S., & Guoqiang, Z. (2011). The clinical observation of the effect of Armillarisin in treating acute biliary tract infection. Journal of Zhejiang Trauma Surgery,\n                  16(6), 825\u2013826.","journal-title":"Journal of Zhejiang Trauma Surgery"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0413-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-014-0413-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0413-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-0413-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:39:41Z","timestamp":1602268781000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-014-0413-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,25]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["413"],"URL":"https:\/\/doi.org\/10.1007\/s12013-014-0413-7","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,25]]},"assertion":[{"value":"25 November 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}