{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:34:11Z","timestamp":1767652451864},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T00:00:00Z","timestamp":1399334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s12013-014-9993-5","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T20:51:21Z","timestamp":1399323081000},"page":"1489-1498","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treg\/Th17 Ratio Acts as a Novel Indicator for Acute Coronary Syndrome"],"prefix":"10.1007","volume":"70","author":[{"given":"Qing","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,6]]},"reference":[{"key":"9993_CR1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1471-4906(01)01922-6","volume":"22","author":"Y Shoenfeld","year":"2001","unstructured":"Shoenfeld, Y., Sherer, Y., & Harats, D. (2001). Artherosclerosis as an infectious, inflammatory and autoimmune disease. Trends in Immunology, 22, 293\u2013295.","journal-title":"Trends in Immunology"},{"key":"9993_CR2","first-page":"109","volume":"50","author":"G Rodr\u00edguez","year":"2009","unstructured":"Rodr\u00edguez, G., Mago, N., & Rosa, F. (2009). Role of inflammation in atherogenesis. Investigacion Clinica, 50, 109\u2013129.","journal-title":"Investigacion Clinica"},{"key":"9993_CR3","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","volume":"352","author":"GK Hansson","year":"2005","unstructured":"Hansson, G. K. (2005). Inflammation, atherosclerosis, and coronary artery disease. New England Journal of Medicine, 352, 1685\u20131695.","journal-title":"New England Journal of Medicine"},{"key":"9993_CR4","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1001\/jama.294.20.2623","volume":"294","author":"CJ Swap","year":"2005","unstructured":"Swap, C. J., & Nagurney, J. T. (2005). Value and limitations of chest pain history in the evaluation of patients with suspected acute coronary syndromes. Journal of the American Medical Association, 294, 2623\u20132629.","journal-title":"Journal of the American Medical Association"},{"key":"9993_CR5","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/01.CIR.0000015464.18023.0A","volume":"105","author":"MS Sabatine","year":"2002","unstructured":"Sabatine, M. S., Morrow, D. A., de Lemos, J. A., et al. (2002). Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: Simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide. Circulation, 105, 1760\u20131763.","journal-title":"Circulation"},{"key":"9993_CR6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-065X.2001.1820102.x","volume":"182","author":"S Sakaguchi","year":"2001","unstructured":"Sakaguchi, S., Sakaguchi, N., Shimizu, J., et al. (2001). Immunologic tolerance maintained by CD25+CD4+regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunological Reviews, 182, 18\u201332.","journal-title":"Immunological Reviews"},{"key":"9993_CR7","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","volume":"361","author":"P Miossec","year":"2009","unstructured":"Miossec, P., Korn, T., & Kuchroo, V. K. (2009). Interleukin-17 and type 17 helper T cells. New England Journal of Medicine, 361, 888\u2013898.","journal-title":"New England Journal of Medicine"},{"key":"9993_CR8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00296-010-1710-0","volume":"32","author":"W Wang","year":"2012","unstructured":"Wang, W., Shao, S., Jiao, Z., et al. (2012). The Th17\/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatology International, 32, 887\u2013893.","journal-title":"Rheumatology International"},{"key":"9993_CR9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clim.2008.01.009","volume":"127","author":"X Cheng","year":"2008","unstructured":"Cheng, X., Yu, X., Ding, Y. J., et al. (2008). The Th17\/Treg imbalance in patients with acute coronary syndrome. Clinical Immunology, 127, 89\u201397.","journal-title":"Clinical Immunology"},{"key":"9993_CR10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbrc.2010.03.090","volume":"394","author":"Qing Li","year":"2010","unstructured":"Li, Qing, Wang, Yi, Chen, Ke, et al. (2010). The role of oxidized low-density lipoprotein in breaking peripheral Th17\/Treg balance in patients with acute coronary syndrome. Biochemical and Biophysical Research Communications, 394, 836\u2013842.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"9993_CR11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cyto.2009.09.007","volume":"49","author":"JJ Xie","year":"2010","unstructured":"Xie, J. J., Wang, J., Tang, T. T., et al. (2010). The Th17\/Treg functional imbalance during atherogenesis in ApoE(-\/-) mice. Cytokine, 49, 185\u2013193.","journal-title":"Cytokine"},{"key":"9993_CR12","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/01.ATV.0000033829.14012.18","volume":"22","author":"K Nishi","year":"2002","unstructured":"Nishi, K., Itabe, H., Uno, M., et al. (2002). Oxidized LDL in carotid plaques and plasma associates with plaque instability. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 1649\u20131654.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9993_CR13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nm1343","volume":"12","author":"H Ait-Oufella","year":"2006","unstructured":"Ait-Oufella, H., Salomon, B. L., Potteaux, S., et al. (2006). Natural regulatory T cells control the development of atherosclerosis in mice. Nature Medicine, 12, 178\u2013180.","journal-title":"Nature Medicine"},{"key":"9993_CR14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.ATV.0000259365.31469.89","volume":"27","author":"A Mor","year":"2007","unstructured":"Mor, A., Planer, D., Luboshits, G., et al. (2007). Role of naturally occurring CD4\u00a0+\u00a0CD25\u00a0+\u00a0regulatory T cells in experimental atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 893\u2013900.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"9993_CR15","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1093\/eurheartj\/ehl222","volume":"27","author":"A Mor","year":"2006","unstructured":"Mor, A., Luboshits, G., Planer, D., et al. (2006). Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes. European Heart Journal, 27, 2530\u20132537.","journal-title":"European Heart Journal"},{"key":"9993_CR16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molimm.2008.12.019","volume":"47","author":"S Romagnani","year":"2009","unstructured":"Romagnani, S., Maggi, E., Liotta, F., et al. (2009). Properties and origin of human Th17 cells. Molecular Immunology, 47, 3\u20137.","journal-title":"Molecular Immunology"},{"key":"9993_CR17","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.atherosclerosis.2011.03.043","volume":"217","author":"Z Zhao","year":"2011","unstructured":"Zhao, Z., Wu, Y., Cheng, M., et al. (2011). Activation of Th17\/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome. Atherosclerosis, 217, 518\u2013524.","journal-title":"Atherosclerosis"},{"key":"9993_CR18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/01.mca.0000236288.94553.b4","volume":"17","author":"S Hashmi","year":"2006","unstructured":"Hashmi, S., & Zeng, Q. T. (2006). Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery disease. Coronary Artery Disease, 17, 699\u2013706.","journal-title":"Coronary Artery Disease"},{"key":"9993_CR19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s10557-011-6341-5","volume":"25","author":"S Mitra","year":"2011","unstructured":"Mitra, S., Goyal, T., & Mehta, J. L. (2011). Oxidized LDL, LOX-1 and atherosclerosis. Cardiovascular Drugs and Therapy, 25, 419\u2013429.","journal-title":"Cardiovascular Drugs and Therapy"},{"key":"9993_CR20","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1161\/01.CIR.103.15.1955","volume":"103","author":"S Ehara","year":"2001","unstructured":"Ehara, S., Ueda, M., Naruko, T., et al. (2001). Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes. Circulation, 103, 1955\u20131960.","journal-title":"Circulation"},{"key":"9993_CR21","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1253\/circj.71.681","volume":"71","author":"H Yamashita","year":"2007","unstructured":"Yamashita, H., Ehara, S., Yoshiyama, M., et al. (2007). Elevated plasma levels of oxidized low-density lipoprotein relate to the presence of angiographically detected complex and thrombotic coronary artery lesion morphology in patients with unstable angina. Circulation Journal, 71, 681\u2013687.","journal-title":"Circulation Journal"},{"key":"9993_CR22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s12013-011-9295-0","volume":"62","author":"YC Zhang","year":"2012","unstructured":"Zhang, Y. C., Wei, J. J., Wang, F., et al. (2012). Elevated levels of oxidized low-density lipoprotein correlate positively with C-reactive protein in patients with acute coronary syndrome. Cell Biochemistry and Biophysics, 62, 365\u2013372.","journal-title":"Cell Biochemistry and Biophysics"},{"key":"9993_CR23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.CIR.0000029802.88087.5E","volume":"106","author":"S Verma","year":"2002","unstructured":"Verma, S., Wang, C. H., Li, S. H., et al. (2002). A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation, 106, 913\u2013919.","journal-title":"Circulation"},{"key":"9993_CR24","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1161\/01.CIR.0000033116.22237.F9","volume":"106","author":"SK Venugopal","year":"2002","unstructured":"Venugopal, S. K., Devaraj, S., Yuhanna, I., et al. (2002). Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation, 106, 1439\u20131441.","journal-title":"Circulation"},{"key":"9993_CR25","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","volume":"102","author":"V Pasceri","year":"2000","unstructured":"Pasceri, V., Willerson, J. T., & Yeh, E. T. (2000). Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation, 102, 2165\u20132168.","journal-title":"Circulation"},{"key":"9993_CR26","first-page":"164","volume":"2","author":"LM Biasucci","year":"2001","unstructured":"Biasucci, L. M., Liuzzo, G., Colizzi, C., et al. (2001). Clinical use of C-reactive protein for the prognostic stratification of patients with ischemic heart disease. Italian Heart Journal, 2, 164\u2013171.","journal-title":"Italian Heart Journal"},{"key":"9993_CR27","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.amjcard.2004.05.062","volume":"15","author":"J Sanchis","year":"2004","unstructured":"Sanchis, J., Bodi, V., Llacer, A., et al. (2004). Usefulness of C-reactive protein and left ventricular function for risk assessment in survivors of acute myocardial infarction. American Journal of Cardiology, 15, 766\u2013769.","journal-title":"American Journal of Cardiology"},{"key":"9993_CR28","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/S0735-1097(98)00469-0","volume":"32","author":"G Dangas","year":"1998","unstructured":"Dangas, G., Mehran, R., Harpel, P. C., et al. (1998). Lipoprotein(a) and inflammation in human coronary atheroma: Association with the severity of clinical presentation. Journal of the American College of Cardiology, 32, 2035\u20132042.","journal-title":"Journal of the American College of Cardiology"},{"key":"9993_CR29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3349\/ymj.2003.44.3.445","volume":"44","author":"SK Ryu","year":"2003","unstructured":"Ryu, S. K., Hong, B. K., Kwon, H. M., et al. (2003). Age-related contribution of Lp(a) with coronary artery calcification in patients with acute coronary syndrome: A potential role of metabolic disorder in calcified plaque. Yonsei Medical Journal, 44, 445\u2013453.","journal-title":"Yonsei Medical Journal"},{"key":"9993_CR30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0733-8627(05)70186-3","volume":"19","author":"DJ Karras","year":"2001","unstructured":"Karras, D. J., & Kane, D. L. (2001). Serum markers in the emergency department diagnosis of acute myocardial infarction. Emergency Medicine Clinics of North America, 19, 321\u2013337.","journal-title":"Emergency Medicine Clinics of North America"},{"key":"9993_CR31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/00365510601175976","volume":"67","author":"IM Penttil\u00e4","year":"2007","unstructured":"Penttil\u00e4, I. M., Laatikainen, A., Penttil\u00e4, K., et al. (2007). Imprecision of cardiac marker analyses among laboratories on the basis of external quality assurance results: Finnish experience. Scandinavian Journal of Clinical and Laboratory Investigation, 67, 507\u2013518.","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-9993-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-014-9993-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-014-9993-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T01:44:39Z","timestamp":1559439879000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-014-9993-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,6]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["9993"],"URL":"https:\/\/doi.org\/10.1007\/s12013-014-9993-5","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,6]]}}}