{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:15:12Z","timestamp":1761920112962},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s12013-016-0725-x","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T23:08:19Z","timestamp":1456355299000},"page":"277-283","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["ZFX Facilitates Cell Proliferation and Imatinib Resistance in Chronic Myeloid Leukemia Cells"],"prefix":"10.1007","volume":"74","author":[{"given":"Jingjing","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"issue":"9976","key":"725_CR1","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/S0140-6736(13)62120-0","volume":"385","author":"JF Apperley","year":"2015","unstructured":"Apperley, J. F. (2015). Chronic myeloid leukaemia. Lancet, \n                           385(9976), 1447\u20131459.","journal-title":"Lancet"},{"issue":"3","key":"725_CR2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nrc1567","volume":"5","author":"R Ren","year":"2005","unstructured":"Ren, R. (2005). Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nature Reviews Cancer, \n                           5(3), 172\u2013183.","journal-title":"Nature Reviews Cancer"},{"issue":"2","key":"725_CR3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/sj.leu.2403241","volume":"18","author":"LS Steelman","year":"2004","unstructured":"Steelman, L. S., Pohnert, S. C., Shelton, J. G., Franklin, R. A., Bertrand, F. E., & McCubrey, J. A. (2004). JAK\/STAT, Raf\/MEK\/ERK, PI3K\/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia, \n                           18(2), 189\u2013218.","journal-title":"Leukemia"},{"issue":"14","key":"725_CR4","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","volume":"344","author":"BJ Druker","year":"2001","unstructured":"Druker, B. J., Talpaz, M., Resta, D. J., Peng, B., Buchdunger, E., Ford, J. M., et al. (2001). Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. The New England Journal of Medicine, \n                           344(14), 1031\u20131037.","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"725_CR5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1182\/blood-2002-02-0545","volume":"101","author":"HM Kantarjian","year":"2003","unstructured":"Kantarjian, H. M., Cortes, J. E., O\u2019Brien, S., Giles, F., Garcia-Manero, G., Faderl, S., et al. (2003). Imatinib mesylate therapy in newly diagnosed patients with Philadelphia chromosome-positive chronic myelogenous leukemia: High incidence of early complete and major cytogenetic responses. Blood, \n                           101(1), 97\u2013100.","journal-title":"Blood"},{"issue":"11","key":"725_CR6","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1038\/sj.leu.2402741","volume":"16","author":"A Hochhaus","year":"2002","unstructured":"Hochhaus, A., Kreil, S., Corbin, A. S., La Rosee, P., Muller, M. C., Lahaye, T., et al. (2002). Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia, \n                           16(11), 2190\u20132196.","journal-title":"Leukemia"},{"issue":"5","key":"725_CR7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.clml.2013.03.018","volume":"13","author":"EJ Jabbour","year":"2013","unstructured":"Jabbour, E. J., Cortes, J. E., & Kantarjian, H. M. (2013). Resistance to tyrosine kinase inhibition therapy for chronic myelogenous leukemia: A clinical perspective and emerging treatment options. Clinical Lymphoma Myeloma and Leukemia, \n                           13(5), 515\u2013529.","journal-title":"Clinical Lymphoma Myeloma and Leukemia"},{"issue":"1","key":"725_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0959-440X(00)00167-6","volume":"11","author":"JH Laity","year":"2001","unstructured":"Laity, J. H., Lee, B. M., & Wright, P. E. (2001). Zinc finger proteins: New insights into structural and functional diversity. Current Opinion in Structural Biology, \n                           11(1), 39\u201346.","journal-title":"Current Opinion in Structural Biology"},{"issue":"1","key":"725_CR9","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1139\/g03-099","volume":"47","author":"A Poloumienko","year":"2004","unstructured":"Poloumienko, A. (2004). Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY. Genome G\u00e9nome\/Conseil National De Recherches Canada, \n                           47(1), 74\u201383.","journal-title":"Genome G\u00e9nome\/Conseil National De Recherches Canada"},{"issue":"2","key":"725_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.cell.2007.04.002","volume":"129","author":"S Cellot","year":"2007","unstructured":"Cellot, S., & Sauvageau, G. (2007). Zfx: At the crossroads of survival and self-renewal. Cell, \n                           129(2), 239\u2013241.","journal-title":"Cell"},{"issue":"2","key":"725_CR11","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.cell.2007.03.014","volume":"129","author":"JM Galan-Caridad","year":"2007","unstructured":"Galan-Caridad, J. M., Harel, S., Arenzana, T. L., Hou, Z. E., Doetsch, F. K., Mirny, L. A., et al. (2007). Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell, \n                           129(2), 345\u2013357.","journal-title":"Cell"},{"issue":"8","key":"725_CR12","doi-asserted-by":"publisher","first-page":"e42302","DOI":"10.1371\/journal.pone.0042302","volume":"7","author":"S Harel","year":"2012","unstructured":"Harel, S., Tu, E. Y., Weisberg, S., Esquilin, M., Chambers, S. M., Liu, B., et al. (2012). ZFX controls the self-renewal of human embryonic stem cells. PLoS One, \n                           7(8), e42302.","journal-title":"PLoS One"},{"issue":"10","key":"725_CR13","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1038\/cgt.2012.53","volume":"19","author":"H Jiang","year":"2012","unstructured":"Jiang, H., Zhang, L., Liu, J., Chen, Z., Na, R., Ding, G., et al. (2012). Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9. Cancer Gene Therapy, \n                           19(10), 684\u2013689.","journal-title":"Cancer Gene Therapy"},{"issue":"4","key":"725_CR14","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3727\/096504012X13548165987493","volume":"20","author":"M Jiang","year":"2012","unstructured":"Jiang, M., Xu, S., Yue, W., Zhao, X., Zhang, L., Zhang, C., et al. (2012). The role of ZFX in non-small cell lung cancer development. Oncology Research, \n                           20(4), 171\u2013178.","journal-title":"Oncology Research"},{"issue":"2","key":"725_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.canlet.2013.04.003","volume":"337","author":"S Wu","year":"2013","unstructured":"Wu, S., Lao, X. Y., Sun, T. T., Ren, L. L., Kong, X., Wang, J. L., et al. (2013). Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway. Cancer Letters, \n                           337(2), 293\u2013300.","journal-title":"Cancer Letters"},{"issue":"1","key":"725_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11060-012-1032-z","volume":"112","author":"Z Zhu","year":"2013","unstructured":"Zhu, Z., Li, K., Xu, D., Liu, Y., Tang, H., Xie, Q., et al. (2013). ZFX regulates glioma cell proliferation and survival in vitro and in vivo. Journal of Neuro-oncology, \n                           112(1), 17\u201325.","journal-title":"Journal of Neuro-oncology"},{"issue":"3","key":"725_CR17","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00280-014-2379-y","volume":"73","author":"H Yang","year":"2014","unstructured":"Yang, H., Lu, Y., Zheng, Y., Yu, X., Xia, X., He, X., et al. (2014). shRNA-mediated silencing of ZFX attenuated the proliferation of breast cancer cells. Cancer Chemotherapy and Pharmacology, \n                           73(3), 569\u2013576.","journal-title":"Cancer Chemotherapy and Pharmacology"},{"issue":"3","key":"725_CR18","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.celrep.2014.01.007","volume":"6","author":"SP Weisberg","year":"2014","unstructured":"Weisberg, S. P., Smith-Raska, M. R., Esquilin, J. M., Zhang, J., Arenzana, T. L., Lau, C. M., et al. (2014). ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia. Cell Reports, \n                           6(3), 528\u2013540.","journal-title":"Cell Reports"},{"issue":"6","key":"725_CR19","first-page":"337","volume":"25","author":"J Qi","year":"2004","unstructured":"Qi, J., Peng, H., Gu, Z. L., Liang, Z. Q., & Yang, C. Z. (2004). Establishment of an imatinib resistant cell line K562\/G01 and its characterization. Zhonghua Xue Ye Xue Za Zhi, \n                           25(6), 337\u2013341.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"issue":"5","key":"725_CR20","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1600-0609.2010.01416.x","volume":"84","author":"I Conde","year":"2010","unstructured":"Conde, I., Pabon, D., Jayo, A., Lastres, P., & Gonzalez-Manchon, C. (2010). Involvement of ERK1\/2, p38 and PI3K in megakaryocytic differentiation of K562 cells. European Journal of Haematology, \n                           84(5), 430\u2013440.","journal-title":"European Journal of Haematology"},{"issue":"1","key":"725_CR21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3892\/or.2014.3572","volume":"33","author":"J Yin","year":"2015","unstructured":"Yin, J., Jiang, Y., Wu, H., Wang, J., Zhang, S., & Liu, H. (2015). Overexpression of ZFX and its involvement in squamous cell carcinoma of the tongue. Oncology Reports, \n                           33(1), 141\u2013148.","journal-title":"Oncology Reports"},{"issue":"8","key":"725_CR22","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1002\/ijc.28819","volume":"135","author":"KP Lai","year":"2014","unstructured":"Lai, K. P., Chen, J., He, M., Ching, A. K., Lau, C., Lai, P. B., et al. (2014). Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma. International Journal of Cancer, \n                           135(8), 1790\u20131799.","journal-title":"International Journal of Cancer"},{"issue":"11","key":"725_CR23","first-page":"2460","volume":"6","author":"K Li","year":"2013","unstructured":"Li, K., Zhu, Z. C., Liu, Y. J., Liu, J. W., Wang, H. T., Xiong, Z. Q., et al. (2013). ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. International Journal of Clinical and Experimental Pathology, \n                           6(11), 2460\u20132467.","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"10\u201312","key":"725_CR24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.cancergen.2014.08.007","volume":"207","author":"Q Fang","year":"2014","unstructured":"Fang, Q., Fu, W. H., Yang, J., Li, X., Zhou, Z. S., Chen, Z. W., et al. (2014). Knockdown of ZFX suppresses renal carcinoma cell growth and induces apoptosis. Cancer Genetics, \n                           207(10\u201312), 461\u2013466.","journal-title":"Cancer Genetics"},{"issue":"11","key":"725_CR25","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.leukres.2013.08.019","volume":"37","author":"H Zhang","year":"2013","unstructured":"Zhang, H., Chang, G., Wang, J., Lin, Y., Ma, L., & Pang, T. (2013). CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment. Leukemia Research, \n                           37(11), 1583\u20131591.","journal-title":"Leukemia Research"},{"issue":"4","key":"725_CR26","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.bbrc.2014.03.086","volume":"446","author":"H Wang","year":"2014","unstructured":"Wang, H., Yu, J., Zhang, L., Xiong, Y., Chen, S., Xing, H., et al. (2014). RPS27a promotes proliferation, regulates cell cycle progression and inhibits apoptosis of leukemia cells. Biochemical and Biophysical Research Communications, \n                           446(4), 1204\u20131210.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"725_CR27","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12013-015-0668-7","volume":"73","author":"Y Wang","year":"2015","unstructured":"Wang, Y., Jiang, Y., Bian, C., Dong, Y., Ma, C., Hu, X., et al. (2015). Overexpression of Hiwi inhibits the cell growth of chronic myeloid leukemia K562 cells and enhances their chemosensitivity to daunomycin. Cell Biochemistry and Biophysics, \n                           73(1), 129\u2013135.","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"1\u20132","key":"725_CR28","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s11010-011-1069-x","volume":"360","author":"J Fang","year":"2012","unstructured":"Fang, J., Yu, Z., Lian, M., Ma, H., Tai, J., Zhang, L., et al. (2012). Knockdown of zinc finger protein, X-linked (ZFX) inhibits cell proliferation and induces apoptosis in human laryngeal squamous cell carcinoma. Molecular and Cellular Biochemistry, \n                           360(1\u20132), 301\u2013307.","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"20","key":"725_CR29","doi-asserted-by":"publisher","first-page":"5914","DOI":"10.1158\/0008-5472.CAN-14-0834","volume":"74","author":"CJ Palmer","year":"2014","unstructured":"Palmer, C. J., Galan-Caridad, J. M., Weisberg, S. P., Lei, L., Esquilin, J. M., Croft, G. F., et al. (2014). Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Research, \n                           74(20), 5914\u20135924.","journal-title":"Cancer Research"},{"issue":"10","key":"725_CR30","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1038\/sj.leu.2403898","volume":"19","author":"A Burchert","year":"2005","unstructured":"Burchert, A., Wang, Y., Cai, D., von, B. N., Paschka, P., Muller-Brusselbach, S., et al. (2005). Compensatory PI3-kinase\/Akt\/mTor activation regulates imatinib resistance development. Leukemia, \n                           19(10), 1774\u20131782.","journal-title":"Leukemia"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0725-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-016-0725-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0725-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0725-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:16:55Z","timestamp":1602267415000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-016-0725-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,24]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["725"],"URL":"https:\/\/doi.org\/10.1007\/s12013-016-0725-x","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,24]]},"assertion":[{"value":"31 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}