{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:23:37Z","timestamp":1785936217845,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s12013-016-0728-7","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T06:16:05Z","timestamp":1461046565000},"page":"129-139","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Biophysical Aspect of Huntingtin Protein During polyQ: An In Silico Insight"],"prefix":"10.1007","volume":"74","author":[{"given":"Chandrasekhar","family":"Gopalakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shraddha","family":"Jethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Kalsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituraj","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"728_CR1","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"HDCTG","year":"1993","unstructured":"HDCTG. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell, \n                           72, 971\u2013983.","journal-title":"Cell"},{"key":"728_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/378403a0","volume":"378","author":"Y Trottier","year":"1995","unstructured":"Trottier, Y., et al. (1995). Polyglutamine expansion as a pathological epitope in Huntington\u2019s disease and four dominant cerebellar ataxias. Nature, \n                           378, 403\u2013406.","journal-title":"Nature"},{"key":"728_CR3","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","volume":"14","author":"M DiFiglia","year":"1995","unstructured":"DiFiglia, M., et al. (1995). Huntington is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron, \n                           14, 1075\u20131081.","journal-title":"Neuron"},{"key":"728_CR4","doi-asserted-by":"publisher","first-page":"44889","DOI":"10.1074\/jbc.M106575200","volume":"276","author":"Y Chai","year":"2001","unstructured":"Chai, Y., et al. (2001). The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease. Journal of Biological Chemistry, \n                           276, 44889\u201344897.","journal-title":"Journal of Biological Chemistry"},{"key":"728_CR5","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1093\/hmg\/7.9.1463","volume":"7","author":"PW Faber","year":"1998","unstructured":"Faber, P. W., et al. (1998). Huntington interacts with a family of WW domain proteins. Human Molecular Genetics, \n                           7, 1463\u20131474.","journal-title":"Human Molecular Genetics"},{"key":"728_CR6","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1073\/pnas.100110097","volume":"97","author":"JS Steffan","year":"2000","unstructured":"Steffan, J. S., et al. (2000). The Huntington\u2019s disease protein interactswith p53 and CREB-binding protein and represses transcription. Proceedings of the National Academy of Sciences USA, \n                           97, 6763\u20136768.","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"728_CR7","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1059581","volume":"293","author":"C Zuccato","year":"2001","unstructured":"Zuccato, C., et al. (2001). Loss of Huntington-mediated BDNF gene transcription in Huntington\u2019s disease. Science, \n                           293, 493\u2013498.","journal-title":"Science"},{"key":"728_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/S0166-2236(00)01721-5","volume":"24","author":"E Cattaneo","year":"2001","unstructured":"Cattaneo, E., et al. (2001). Loss of normal huntington function: New developments in Huntington\u2019s disease research. Trends in Neurosciences, \n                           24, 182\u2013188.","journal-title":"Trends in Neurosciences"},{"key":"728_CR9","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1093\/hmg\/8.9.1647","volume":"8","author":"JM Boutell","year":"1999","unstructured":"Boutell, J. M., et al. (1999). Aberrant interactions of transcriptional repressor proteins with the Huntington\u2019s disease gene product, Huntington. Human Molecular Genetics, \n                           8, 1647\u20131655.","journal-title":"Human Molecular Genetics"},{"key":"728_CR10","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1126\/science.1072613","volume":"296","author":"AW Dunah","year":"2002","unstructured":"Dunah, A. W., et al. (2002). Sp1 and TAFII130 transcriptional activity disrupted in early Huntington\u2019s disease. Science, \n                           296, 2238\u20132243.","journal-title":"Science"},{"key":"728_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/35044540","volume":"1","author":"VI Slepnev","year":"2000","unstructured":"Slepnev, V. I., & De Camilli, P. (2000). Accessory factors in clathrin dependent synaptic vesicle endocytosis. Nature Reviews Neuroscience, \n                           1, 161\u2013172.","journal-title":"Nature Reviews Neuroscience"},{"key":"728_CR12","doi-asserted-by":"publisher","first-page":"24713","DOI":"10.1074\/jbc.M103501200","volume":"276","author":"Y Sun","year":"2001","unstructured":"Sun, Y., et al. (2001). Polyglutamine-expanded Huntington promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95. Journal of Biological Chemistry, \n                           276, 24713\u201324718.","journal-title":"Journal of Biological Chemistry"},{"key":"728_CR13","volume-title":"Huntington\u2019s disease","author":"G Bates","year":"2002","unstructured":"Bates, G., et al. (2002). Huntington\u2019s disease (3rd ed.). New York: Oxford University Press.","edition":"3"},{"issue":"1","key":"728_CR14","first-page":"21","volume":"31","author":"A Ontoya","year":"2006","unstructured":"Ontoya, A., Price, B. H., Menear, M., & Lepage, M. (2006). Brain imaging and cognitive dysfunctions in Huntington\u2019s disease. The Journal of Psychiatry & Neuroscience, \n                           31(1), 21\u201329.","journal-title":"The Journal of Psychiatry & Neuroscience"},{"key":"728_CR15","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"JP Vonsattel","year":"1985","unstructured":"Vonsattel, J. P., et al. (1985). Neuropathological classification of Huntington\u2019s disease. Journal of Neuropathology and Experimental Neurology, \n                           44, 559\u2013577.","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"728_CR16","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0896-6273(03)00594-4","volume":"40","author":"S Gunawardena","year":"2003","unstructured":"Gunawardena, S., et al. (2003). Disruption of axonal transport by loss of Huntington or expression of pathogenic polyQ proteins in Drosophila. Neuron, \n                           40, 25\u201340.","journal-title":"Neuron"},{"key":"728_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0896-6273(03)00569-5","volume":"40","author":"G Szebenyi","year":"2003","unstructured":"Szebenyi, G., et al. (2003). Neuropathogenic forms of Huntington and androgen receptor inhibit fast axonal transport. Neuron, \n                           40, 41\u201352.","journal-title":"Neuron"},{"issue":"8","key":"728_CR18","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","volume":"8","author":"JM Van der Burg","year":"2009","unstructured":"Van der Burg, J. M., Bj\u00f6rkqvist, M., & Brundin, P. (2009). Beyond the brain: Widespread pathology in Huntington\u2019s disease. The Lancet Neurology, \n                           8(8), 765\u2013774. doi:\n                    10.1016\/S1474-4422(09)70178-4\n                    \n                  .","journal-title":"The Lancet Neurology"},{"key":"728_CR19","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0092-8674(00)80514-0","volume":"90","author":"E Scherzinger","year":"1997","unstructured":"Scherzinger, E., et al. (1997). Huntington-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo. Cell, \n                           90, 549\u2013558.","journal-title":"Cell"},{"key":"728_CR20","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1515\/BC.2000.114","volume":"381","author":"EE Wanker","year":"2000","unstructured":"Wanker, E. E. (2000). Protein aggregation and pathogenesis of Huntington\u2019s disease: mechanisms and correlations. The Journal of Biological Chemistry, \n                           381, 937\u2013942.","journal-title":"The Journal of Biological Chemistry"},{"key":"728_CR21","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/hmg\/ddi071","volume":"14","author":"MA Poirier","year":"2005","unstructured":"Poirier, M. A., Jiang, H., & Ross, C. A. (2005). A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure. Human Molecular Genetics, \n                           14, 765\u2013774.","journal-title":"Human Molecular Genetics"},{"key":"728_CR22","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","volume":"87","author":"L Mangiarini","year":"1996","unstructured":"Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., et al. (1996). Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, \n                           87, 493\u2013506.","journal-title":"Cell"},{"key":"728_CR23","doi-asserted-by":"publisher","first-page":"16017","DOI":"10.1074\/jbc.M111.252577","volume":"287","author":"LG Nucifora","year":"2012","unstructured":"Nucifora, L. G., Burke, K. A., Feng, X., Arbez, N., Zhu, S., Miller, J., et al. (2012). Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. Journal of Biological Chemistry, \n                           287, 16017\u201316028.","journal-title":"Journal of Biological Chemistry"},{"key":"728_CR24","doi-asserted-by":"publisher","first-page":"8188","DOI":"10.1074\/jbc.M110.192013","volume":"286","author":"QC Zhang","year":"2011","unstructured":"Zhang, Q. C., Yeh, T.-L., Leyva, A., Frank, L. G., Miller, J., Kim, Y. E., et al. (2011). A compact beta model of huntingtin toxicity. Journal of Biological Chemistry, \n                           286, 8188\u20138196.","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"728_CR25","doi-asserted-by":"publisher","first-page":"e20373","DOI":"10.1371\/journal.pone.0020373","volume":"6","author":"Z Zhang","year":"2011","unstructured":"Zhang, Z., Norris, J., Schwartz, C., & Alexov, E. (2011). In silico and in vitro investigations of the mutability of disease-causing missense mutation sites in spermine synthase. PLoS One, \n                           6(5), e20373.","journal-title":"PLoS One"},{"key":"728_CR26","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"M DiFiglia","year":"1997","unstructured":"DiFiglia, M., et al. (1997). Aggregation of Huntington in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, \n                           277, 1990\u20131993.","journal-title":"Science"},{"key":"728_CR27","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/0896-6273(95)90345-3","volume":"14","author":"AH Sharp","year":"1995","unstructured":"Sharp, A. H., et al. (1995). Widespread expression of Huntington\u2019s disease gene (IT15) protein product. Neuron, \n                           14, 1065\u20131074.","journal-title":"Neuron"},{"key":"728_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S1097-2765(00)80142-2","volume":"2","author":"A Sittler","year":"1998","unstructured":"Sittler, A., W\u00e4lter, S., Wedemeyer, N., Hasenbank, R., Scherzinger, E., Eickhoff, H., et al. (1998). SH3GL3 associates with the huntington exon 1 protein and promotes the formation of polygln-containing protein aggregates. Molecular Cell, \n                           2, 427\u2013436.","journal-title":"Molecular Cell"},{"issue":"12","key":"728_CR29","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1093\/hmg\/6.12.2141","volume":"6","author":"Sathasivam","year":"1997","unstructured":"Sathasivam, et al. (1997). Aberrant processing of the Fugu HD (FrHD) mRNA in mouse cells and in transgenic mice. Human Molecular Genetics, \n                           6(12), 2141\u20132149.","journal-title":"Human Molecular Genetics"},{"key":"728_CR30","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1093\/hmg\/11.21.2547","volume":"11","author":"J Modregger","year":"2002","unstructured":"Modregger, J., et al. (2002). PACSIN 1 interacts with Huntington and is absent from synaptic varicosities in presymptomatic Huntington\u2019s disease brains. Human Molecular Genetics, \n                           11, 2547\u20132558.","journal-title":"Human Molecular Genetics"},{"key":"728_CR31","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1046\/j.0953-816X.2000.01379.x","volume":"13","author":"B Nicniocaill","year":"2001","unstructured":"Nicniocaill, B., Haraldsson, B., Hansson, O., O\u2019Connor, W. T., & Brundin, P. (2001). Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6\/1 Huntington transgenic mice. European Journal of Neuroscience, \n                           13, 206\u2013210.","journal-title":"European Journal of Neuroscience"},{"issue":"4","key":"728_CR32","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s00894-010-0785-6","volume":"17","author":"R Purohit","year":"2011","unstructured":"Purohit, R., Rajendran, V., & Sethumadhavan, R. (2011). Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and isoniazid susceptibility: An in silico analysis. Journal of Molecular Modeling, \n                           17(4), 869\u2013877.","journal-title":"Journal of Molecular Modeling"},{"issue":"1","key":"728_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.gene.2012.04.032","volume":"503","author":"A Kumar","year":"2012","unstructured":"Kumar, A., & Purohit, R. (2012). Computational investigation of pathogenic nsSNPs in CEP63 protein. Gene, \n                           503(1), 75\u201382.","journal-title":"Gene"},{"issue":"2","key":"728_CR34","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00726-011-1108-7","volume":"43","author":"V Rajendran","year":"2012","unstructured":"Rajendran, V., Purohit, R., & Sethumadhavan, R. (2012). In silico investigation of molecular mechanism of laminopathy caused by a point mutation (R482W) in lamin A\/C protein. Amino Acids, \n                           43(2), 603\u2013615.","journal-title":"Amino Acids"},{"issue":"2","key":"728_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/07391102.2012.759885","volume":"32","author":"V Rajendran","year":"2014","unstructured":"Rajendran, V., & Sethumadhavan, R. (2014). Drug resistance mechanism of PncA in Mycobacterium tuberculosis. Journal of Biomolecular Structure & Dynamics, \n                           32(2), 209\u2013221.","journal-title":"Journal of Biomolecular Structure & Dynamics"},{"issue":"7","key":"728_CR36","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1080\/07391102.2013.803264","volume":"32","author":"R Purohit","year":"2014","unstructured":"Purohit, R. (2014). Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight. Journal of Biomolecular Structure & Dynamics, \n                           32(7), 1033\u20131046.","journal-title":"Journal of Biomolecular Structure & Dynamics"},{"issue":"1\u20132","key":"728_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-015-2462-7","volume":"409","author":"C Gopalakrishnan","year":"2015","unstructured":"Gopalakrishnan, C., Kalsi, N., Jethi, S., & Purohit, R. (2015). Computational investigation of molecular mechanism and neuropathological implications in Huntington disease. Molecular and Cellular Biochemistry, \n                           409(1\u20132), 1\u201311.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"728_CR38","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2015.1127774","author":"N Kalsi","year":"2016","unstructured":"Kalsi, N., Gopalakrishnan, C., Rajendran, V., & Purohit, R. (2016). Biophysical aspect of phosphatidylinositol 3-kinase and role of oncogenic mutants (E542K & E545K). Journal of Biomolecular Structure & Dynamics,. doi:\n                    10.1080\/07391102.2015.1127774\n                    \n                  .","journal-title":"Journal of Biomolecular Structure & Dynamics"},{"key":"728_CR39","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2105-9-40","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y. (2008). I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, \n                           9, 40.","journal-title":"BMC Bioinformatics"},{"key":"728_CR40","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1021\/ja026939x","volume":"125","author":"C Dominguez","year":"2003","unstructured":"Dominguez, C., Boelens, R., & Bonvin, A. M. (2003). HADDOCK: A protein\u2013protein docking approach based on biochemical or biophysical information. Journal of the American Chemical Society, \n                           125, 1731\u20131737.","journal-title":"Journal of the American Chemical Society"},{"key":"728_CR41","first-page":"883","volume":"5","author":"C Dominguez","year":"2003","unstructured":"Dominguez, C., Boelens, R., & Bonvin, A. M. (2003). The HADDOCK web server for data-driven biomolecular docking. Nature Protocols, \n                           5, 883\u2013897.","journal-title":"Nature Protocols"},{"key":"728_CR42","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1006\/jmbi.1994.0053","volume":"245","author":"M Nilges","year":"1995","unstructured":"Nilges, M. (1995). Calculation of protein structures with ambiguous distance restraints. Automated assignment of ambiguous NOE crosspeaks and disulphide connectivities. Journal of Molecular Biology, \n                           245, 645\u2013660.","journal-title":"Journal of Molecular Biology"},{"key":"728_CR43","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1006\/jmbi.1997.1044","volume":"269","author":"M Nilges","year":"1997","unstructured":"Nilges, M., Macias, M. J., O\u2019Donoghue, S. I., & Oschkinat, H. (1997). Automated NOESY interpretation with ambiguous distance restraints: the refined NMR solution structure of the pleckstrin homology domain from beta-spectrin. Journal of Molecular Biology, \n                           269, 408\u2013422.","journal-title":"Journal of Molecular Biology"},{"key":"728_CR44","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"AT Brunger","year":"1998","unstructured":"Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse- Kunstleve, R. W., et al. (1998). Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallographica. Section D, Biological Crystallography, \n                           54, 905\u2013921.","journal-title":"Acta Crystallographica. Section D, Biological Crystallography"},{"key":"728_CR45","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/prot.21248","volume":"66","author":"A Porollo","year":"2007","unstructured":"Porollo, A., & Meller, J. (2007). Prediction-based fingerprints of protein-protein interactions. Proteins: Structure, Function, and Bioinformatics, \n                           66, 630\u2013645.","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"key":"728_CR46","unstructured":"Porollo, A., & Meller, J. (2012). Computational methods for prediction of protein-protein interaction sites. In W. Cai & H. Hong (Eds.), Protein-protein interactions\u2014computational and experimental tools, InTech (Vol. 472, pp. 3\u201326)."},{"key":"728_CR47","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1021\/ct700301q","volume":"4","author":"B Hess","year":"2008","unstructured":"Hess, B., Kutzner, C., Spoel, D., & Lindahl, E. (2008). GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation. Journal of Chemical Theory and Computation, \n                           4, 435\u2013447.","journal-title":"Journal of Chemical Theory and Computation"},{"key":"728_CR48","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"D Spoel","year":"2005","unstructured":"Spoel D., et al. (2005). GROMACS: Fast, flexible, and free. Journal of Computational Chemistry, \n                           26, 1701\u20131718.","journal-title":"Journal of Computational Chemistry"},{"key":"728_CR49","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/978-94-015-7658-1_21","volume-title":"Intermolecular forces","author":"HJC Berendsen","year":"1981","unstructured":"Berendsen, H. J. C., Postma, J. P. M., Gunsteren, W. F. V., & Hermans, J. (1981). Interaction models for water in relation to protein hydration. In B. Pullman (Ed.), Intermolecular forces (pp. 331\u2013342). Dordrecht: D. Reidel Publishing Company."},{"key":"728_CR50","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1063\/1.448118","volume":"81","author":"HJC Berendsen","year":"1984","unstructured":"Berendsen, H. J. C., Postma, J. P. M., DiNola, A., & Hakk, J. R. (1984). Molecular dynamics with coupling to an external bath. The Journal of Chemical Physics, \n                           81, 3684\u20133690.","journal-title":"The Journal of Chemical Physics"},{"key":"728_CR51","doi-asserted-by":"publisher","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"U Essmann","year":"1995","unstructured":"Essmann, U., Perera, L., Berkowitz, M. L., Darden, T., Lee, H., & Pedersen, L. G. (1995). A smooth particle mesh Ewald method. The Journal of Chemical Physics, \n                           103, 8577\u20138593.","journal-title":"The Journal of Chemical Physics"},{"key":"728_CR52","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/prot.10115","volume":"47","author":"I Halperin","year":"2002","unstructured":"Halperin, I., Ma, B., Wolfson, H., & Nussinov, R. (2002). Principles of docking: An overview of search algorithms and a guide to scoring functions. Proteins: Structure, Function, and Genetics, \n                           47, 409\u2013443.","journal-title":"Proteins: Structure, Function, and Genetics"},{"key":"728_CR53","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/prot.10381","volume":"52","author":"J Janin","year":"2003","unstructured":"Janin, J., Henrick, K., Moult, J., Eyck, L. T., Sternberg, M. J., Vajda, S., et al. (2003). CAPRI: A critical assessment of predicted interactions. Proteins: Structure, Function, and Genetics, \n                           52, 2\u20139.","journal-title":"Proteins: Structure, Function, and Genetics"},{"issue":"11","key":"728_CR54","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1093\/nar\/gkl412","volume":"34","author":"M van Dijk","year":"2006","unstructured":"van Dijk, M., van Dijk, A. D. J., Hsu, V., Boelens, R., & Bonvin, A. M. J. J. (2006). Information-driven protein\u2013DNA docking using HADDOCK: It is a matter of flexibility. Nucleic Acids Research., \n                           34(11), 3317\u20133325. doi:\n                    10.1093\/nar\/gkl412\n                    \n                  .","journal-title":"Nucleic Acids Research."},{"issue":"5","key":"728_CR55","doi-asserted-by":"publisher","first-page":"e82","DOI":"10.1371\/journal.pgen.0030082","volume":"3","author":"LS Kaltenbach","year":"2007","unstructured":"Kaltenbach, L. S., et al. (2007). Huntingtin interacting proteins are genetic modifiers of Neurodegeneration. PLoS Genetics, \n                           3(5), e82.","journal-title":"PLoS Genetics"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0728-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-016-0728-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0728-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0728-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T18:17:10Z","timestamp":1602267430000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-016-0728-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["728"],"URL":"https:\/\/doi.org\/10.1007\/s12013-016-0728-7","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,19]]},"assertion":[{"value":"16 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}