{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:36:40Z","timestamp":1790890600302,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A1A2008452"],"award-info":[{"award-number":["NRF-2013R1A1A2008452"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2015R1D1A1A01060699"],"award-info":[{"award-number":["NRF-2015R1D1A1A01060699"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s12013-016-0771-4","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T04:00:49Z","timestamp":1478664049000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Maturation of Adipocytes is Suppressed by Fluid Shear Stress"],"prefix":"10.1007","volume":"75","author":[{"given":"Jongyun","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Min","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"issue":"11","key":"771_CR1","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm3198","volume":"12","author":"AG Cristancho","year":"2011","unstructured":"Cristancho, A. G., & Lazar, M. A. (2011). Forming functional fat: A growing understanding of adipocyte differentiation. Natural Reviews Molecular Cell Biology, 12(11), 722\u2013734.","journal-title":"Natural Reviews Molecular Cell Biology"},{"issue":"6","key":"771_CR2","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.cmet.2008.11.001","volume":"8","author":"KW Park","year":"2008","unstructured":"Park, K. W., Halperin, D. S., & Tontonoz, P. (2008). Before they were fat: adipocyte progenitors. Cell Metabolism, 8(6), 454\u2013457.","journal-title":"Cell Metabolism"},{"issue":"5","key":"771_CR3","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1242\/dmm.009613","volume":"5","author":"JC Wells","year":"2012","unstructured":"Wells, J. C. (2012). The evolution of human adiposity and obesity: Where did it all go wrong? Diseases Models & Mechanisms, 5(5), 595\u2013607.","journal-title":"Diseases Models & Mechanisms"},{"issue":"3","key":"771_CR4","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0092-8674(00)81359-8","volume":"87","author":"BM Spiegelman","year":"1996","unstructured":"Spiegelman, B. M., & Flier, J. S. (1996). Adipogenesis and obesity: Rounding out the big picture. Cell, 87(3), 377\u2013389.","journal-title":"Cell"},{"issue":"2","key":"771_CR5","doi-asserted-by":"publisher","first-page":"C429","DOI":"10.1152\/ajpcell.00167.2011","volume":"302","author":"N Shoham","year":"2012","unstructured":"Shoham, N., Gottlieb, R., & Sharabani-Yosef, O., et al. (2012). Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway. The American Journal of Physiology: Cell Physiology, 302(2), C429\u2013441.","journal-title":"The American Journal of Physiology: Cell Physiology"},{"issue":"1","key":"771_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbiomech.2011.10.023","volume":"45","author":"N Shoham","year":"2012","unstructured":"Shoham, N., & Gefen, A. (2012). Mechanotransduction in adipocytes. Journal of Biomechanics, 45(1), 1\u20138.","journal-title":"Journal of Biomechanics"},{"issue":"3","key":"771_CR7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.jbiomech.2007.10.011","volume":"41","author":"E Linder-Ganz","year":"2008","unstructured":"Linder-Ganz, E., Shabshin, N., & Itzchak, Y., et al. (2008). Strains and stresses in sub-dermal tissues of the buttocks are greater in paraplegics than in healthy during sitting. Journal of Biomechanics, 41(3), 567\u2013580.","journal-title":"Journal of Biomechanics"},{"issue":"7","key":"771_CR8","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/j.jbiomech.2006.06.020","volume":"40","author":"E Linder-Ganz","year":"2007","unstructured":"Linder-Ganz, E., Shabshin, N., & Itzchak, Y., et al. (2007). Assessment of mechanical conditions in sub-dermal tissues during sitting: A combined experimental-MRI and finite element approach. Journal of Biomechanics, 40(7), 1443\u20131454.","journal-title":"Journal of Biomechanics"},{"issue":"1","key":"771_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.biochi.2004.10.018","volume":"87","author":"F Bost","year":"2005","unstructured":"Bost, F., Aouadi, M., & Caron, L., et al. (2005). The role of MAPKs in adipocyte differentiation and obesity. Biochimie, 87(1), 51\u201356.","journal-title":"Biochimie"},{"issue":"4","key":"771_CR10","doi-asserted-by":"publisher","first-page":"C853","DOI":"10.1152\/ajpcell.00331.2001","volume":"282","author":"F Machinal-Quelin","year":"2002","unstructured":"Machinal-Quelin, F., Dieudonne, M. N., & Leneveu, M. C., et al. (2002). Proadipogenic effect of leptin on rat preadipocytes in vitro: Activation of MAPK and STAT3 signaling pathways. The American Journal of Physiology: Cell Physiology, 282(4), C853\u2013863.","journal-title":"The American Journal of Physiology: Cell Physiology"},{"key":"771_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.abb.2014.05.008","volume":"554","author":"T Zhang","year":"2014","unstructured":"Zhang, T., Yamamoto, N., & Yamashita, Y., et al. (2014). The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK. Archives of Biochemistry and Biophysics, 554, 44\u201354.","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"3","key":"771_CR12","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1002\/jcb.20162","volume":"93","author":"JH Jansen","year":"2004","unstructured":"Jansen, J. H., Weyts, F. A., & Westbroek, I., et al. (2004). Stretch-induced phosphorylation of ERK1\/2 depends on differentiation stage of osteoblasts. Journal of Cellular Biochemistry, 93(3), 542\u2013551.","journal-title":"Journal of Cellular Biochemistry"},{"issue":"4","key":"771_CR13","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/j.1460-2075.1993.tb05813.x","volume":"12","author":"J Sadoshima","year":"1993","unstructured":"Sadoshima, J., & Izumo, S. (1993). Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: Potential involvement of an autocrine\/paracrine mechanism. The EMBO Journal, 12(4), 1681\u20131692.","journal-title":"The EMBO Journal"},{"issue":"3","key":"771_CR14","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.bbrc.2004.12.087","volume":"328","author":"J Iqbal","year":"2005","unstructured":"Iqbal, J., & Zaidi, M. (2005). Molecular regulation of mechanotransduction. Biochemical and Biophysical Research Communications, 328(3), 751\u2013755.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"771_CR15","unstructured":"Tanabe, Y., Saito, M. T., & Nakayama, K. (2015). Mechanical stretching and signaling pathways in adipogenesis. In A. Gefen, D. Benayahu (Eds.), The mechanobiology of obesity and related diseases (pp. 35\u201362). Cham: Springer International Publishing."},{"issue":"5","key":"771_CR16","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1007\/s10439-011-0496-x","volume":"40","author":"A Levy","year":"2012","unstructured":"Levy, A., Enzer, S., & Shoham, N., et al. (2012). Large, but not small sustained tensile strains stimulate adipogenesis in culture. Annals of Biomedical Engineering, 40(5), 1052\u20131060.","journal-title":"Annals of Biomedical Engineering"},{"issue":"157","key":"771_CR17","doi-asserted-by":"publisher","first-page":"ra3","DOI":"10.1126\/scisignal.2001227","volume":"4","author":"Y Hara","year":"2011","unstructured":"Hara, Y., Wakino, S., & Tanabe, Y., et al. (2011). Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. Science Signaling, 4(157), ra3.","journal-title":"Science Signaling"},{"issue":"3","key":"771_CR18","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jbiosc.2009.09.003","volume":"109","author":"MG Hossain","year":"2010","unstructured":"Hossain, M. G., Iwata, T., & Mizusawa, N., et al. (2010). Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARgamma2 and C\/EBPalpha. Journal of Bioscience and Bioengineering, 109(3), 297\u2013303.","journal-title":"Journal of Bioscience and Bioengineering"},{"issue":"Pt 16","key":"771_CR19","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1242\/jcs.01207","volume":"117","author":"Y Tanabe","year":"2004","unstructured":"Tanabe, Y., Koga, M., & Saito, M., et al. (2004). Inhibition of adipocyte differentiation by mechanical stretching through ERK-mediated downregulation of PPARgamma2. Journal of Cell Science, 117(Pt 16), 3605\u20133614.","journal-title":"Journal of Cell Science"},{"key":"771_CR20","first-page":"863421","volume":"2014","author":"YX Qin","year":"2014","unstructured":"Qin, Y. X., & Hu, M. (2014). Mechanotransduction in musculoskeletal tissue regeneration: Effects of fluid flow, loading, and cellular-molecular pathways. BioMed Research International, 2014, 863421.","journal-title":"BioMed Research International"},{"issue":"2","key":"771_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1359\/jbmr.2002.17.2.266","volume":"17","author":"S Wadhwa","year":"2002","unstructured":"Wadhwa, S., Godwin, S. L., & Peterson, D. R., et al. (2002). Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway. Journal of Bone and Mineral Research, 17(2), 266\u2013274.","journal-title":"Journal of Bone and Mineral Research"},{"issue":"1","key":"771_CR22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0021-9290(99)00176-1","volume":"33","author":"CT Hung","year":"2000","unstructured":"Hung, C. T., Henshaw, D. R., & Wang, C. C., et al. (2000). Mitogen-activated protein kinase signaling in bovine articular chondrocytes in response to fluid flow does not require calcium mobilization. Journal of Biomechanics, 33(1), 73\u201380.","journal-title":"Journal of Biomechanics"},{"issue":"6","key":"771_CR23","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s10237-010-0285-8","volume":"10","author":"TM Maul","year":"2011","unstructured":"Maul, T. M., Chew, D. W., & Nieponice, A., et al. (2011). Mechanical stimuli differentially control stem cell behavior: Morphology, proliferation, and differentiation. Biomechanics and Modeling in Mechanobiology, 10(6), 939\u2013953.","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"issue":"1","key":"771_CR24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1073\/pnas.0137044100","volume":"100","author":"QQ Tang","year":"2003","unstructured":"Tang, Q. Q., Otto, T. C., & Lane, M. D. (2003). Mitotic clonal expansion: A synchronous process required for adipogenesis. Proceedings of the National Academy of Sciences of the USA, 100(1), 44\u201349.","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"771_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1146\/annurev.cellbio.13.1.231","volume":"13","author":"CS Hwang","year":"1997","unstructured":"Hwang, C. S., Loftus, T. M., & Mandrup, S., et al. (1997). Adipocyte differentiation and leptin expression. Annual Review of Cell and Developmental Biology, 13, 231\u2013259.","journal-title":"Annual Review of Cell and Developmental Biology"},{"issue":"4","key":"771_CR26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.nutres.2014.12.009","volume":"35","author":"Q Wang","year":"2015","unstructured":"Wang, Q., Wang, S. T., & Yang, X., et al. (2015). Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes. Nutrition Research, 35(4), 317\u2013327.","journal-title":"Nutrition Research"},{"issue":"12","key":"771_CR27","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nrm2066","volume":"7","author":"ED Rosen","year":"2006","unstructured":"Rosen, E. D., & MacDougald, O. A. (2006). Adipocyte differentiation from the inside out. Nature Reviews Molecular Cell Biology, 7(12), 885\u2013896.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"10","key":"771_CR28","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1039\/C5IB00056D","volume":"7","author":"S Abuhattum","year":"2015","unstructured":"Abuhattum, S., Gefen, A., & Weihs, D. (2015). Ratio of total traction force to projected cell area is preserved in differentiating adipocytes. Integrative Biology (Cambridge), 7(10), 1212\u20131217.","journal-title":"Integrative Biology (Cambridge)"},{"issue":"6","key":"771_CR29","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.bpj.2014.01.045","volume":"106","author":"N Shoham","year":"2014","unstructured":"Shoham, N., Girshovitz, P., & Katzengold, R., et al. (2014). Adipocyte stiffness increases with accumulation of lipid droplets. Biophysical Journal, 106(6), 1421\u20131431.","journal-title":"Biophysical Journal"},{"issue":"3","key":"771_CR30","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10237-014-0620-6","volume":"14","author":"R Katzengold","year":"2015","unstructured":"Katzengold, R., Shoham, N., & Benayahu, D., et al. (2015). Simulating single cell experiments in mechanical testing of adipocytes. Biomechanics and Modeling in Mechanobiology, 14(3), 537\u2013547.","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"issue":"1","key":"771_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10237-014-0582-8","volume":"14","author":"M Ben-Or Frank","year":"2015","unstructured":"Ben-Or Frank, M., Shoham, N., & Benayahu, D., et al. (2015). Effects of accumulation of lipid droplets on load transfer between and within adipocytes. Biomechanics and Modeling in Mechanobiology, 14(1), 15\u201328.","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"issue":"5","key":"771_CR32","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.bone.2006.05.017","volume":"39","author":"CH Kim","year":"2006","unstructured":"Kim, C. H., You, L., & Yellowley, C. E., et al. (2006). Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone, 39(5), 1043\u20131047.","journal-title":"Bone"},{"issue":"8","key":"771_CR33","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1002\/jbmr.394","volume":"26","author":"X Wang","year":"2011","unstructured":"Wang, X., Harimoto, K., & Liu, J., et al. (2011). Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway. Journal of Bone and Mineral Research, 26(8), 1964\u20131973.","journal-title":"Journal of Bone and Mineral Research"},{"issue":"5","key":"771_CR34","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1002\/jbmr.2409","volume":"30","author":"Z Chen","year":"2015","unstructured":"Chen, Z., Yue, S. X., & Zhou, G., et al. (2015). ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. Journal of Bone and Mineral Research, 30(5), 765\u2013774.","journal-title":"Journal of Bone and Mineral Research"},{"issue":"4","key":"771_CR35","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.bbrc.2011.01.068","volume":"405","author":"NA Arita","year":"2011","unstructured":"Arita, N. A., Pelaez, D., & Cheung, H. S. (2011). Activation of the extracellular signal-regulated kinases 1 and 2 (ERK1\/2 is needed for the TGFbeta-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells. Biochemical and Biophysical Research Communications, 405(4), 564\u2013569.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"4","key":"771_CR36","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/10409230591008189","volume":"40","author":"TC Otto","year":"2005","unstructured":"Otto, T. C., & Lane, M. D. (2005). Adipose development: from stem cell to adipocyte. Critical Reviews in Biochemistry and Molecular Biology, 40(4), 229\u2013242.","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"issue":"1","key":"771_CR37","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bbrc.2004.04.176","volume":"319","author":"QQ Tang","year":"2004","unstructured":"Tang, Q. Q., Zhang, J. W., & Daniel Lane, M. (2004). Sequential gene promoter interactions of C\/EBPbeta, C\/EBPalpha, and PPARgamma during adipogenesis. Biochemical and Biophysical Research Communications, 319(1), 235\u2013239.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"6","key":"771_CR38","doi-asserted-by":"publisher","first-page":"E1195","DOI":"10.1152\/ajpendo.00513.2004","volume":"288","author":"SE Schadinger","year":"2005","unstructured":"Schadinger, S. E., Bucher, N. L., & Schreiber, B. M., et al. (2005). PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. American Journal of Physiology. Endocrinology and Metabolism, 288(6), E1195\u20131205.","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"10","key":"771_CR39","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1101\/gad.8.10.1224","volume":"8","author":"P Tontonoz","year":"1994","unstructured":"Tontonoz, P., Hu, E., & Graves, R. A., et al. (1994). mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer. Genes & Development, 8(10), 1224\u20131234.","journal-title":"Genes & Development"},{"issue":"14","key":"771_CR40","doi-asserted-by":"publisher","first-page":"9507","DOI":"10.1074\/jbc.M512077200","volume":"281","author":"B Gustafson","year":"2006","unstructured":"Gustafson, B., & Smith, U. (2006). Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. The Journal of Biological Chemistry, 281(14), 9507\u20139516.","journal-title":"The Journal of Biological Chemistry"},{"issue":"5","key":"771_CR41","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.metabol.2016.01.009","volume":"65","author":"SK Choi","year":"2016","unstructured":"Choi, S. K., Park, S., & Jang, S., et al. (2016). Cascade regulation of PPARgamma (2 and C\/EBPalpha signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes. Metabolism, 65(5), 646\u2013654.","journal-title":"Metabolism"},{"issue":"6","key":"771_CR42","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.ceb.2007.09.014","volume":"19","author":"TC Prestwich","year":"2007","unstructured":"Prestwich, T. C., & Macdougald, O. A. (2007). Wnt\/beta-catenin signaling in adipogenesis and metabolism. Current Opinion in Cell Biology, 19(6), 612\u2013617.","journal-title":"Current Opinion in Cell Biology"},{"issue":"5","key":"771_CR43","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/cpr.12053","volume":"46","author":"G Li","year":"2013","unstructured":"Li, G., Fu, N., & Yang, X., et al. (2013). Mechanical compressive force inhibits adipogenesis of adipose stem cells. Cell Proliferation, 46(5), 586\u2013594.","journal-title":"Cell Proliferation"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0771-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12013-016-0771-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-016-0771-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T13:01:14Z","timestamp":1718888474000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12013-016-0771-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["771"],"URL":"https:\/\/doi.org\/10.1007\/s12013-016-0771-4","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]},"assertion":[{"value":"19 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}