{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:12:39Z","timestamp":1760890359188,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100006144","name":"Kerala State Council for Science, Technology and Environment","doi-asserted-by":"publisher","award":["KSCSTE\/2706\/2018-FSHP-LS"],"award-info":[{"award-number":["KSCSTE\/2706\/2018-FSHP-LS"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100006144","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s12013-021-01009-5","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:21:44Z","timestamp":1623248504000},"page":"629-639","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Thermally Oxidized Coconut Oil as Fat Source in High-Fat Diet Induces Hepatic Fibrosis in Diabetic Rat Model"],"prefix":"10.1007","volume":"79","author":[{"given":"Veena","family":"Gopinath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mullam Kunnathu A.","family":"Shamsitha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishak","family":"Penarveettil Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Punnakkal","family":"Seena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rao M.","family":"Uppu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-1780","authenticated-orcid":false,"given":"Achuthan","family":"C. Raghavamenon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"issue":"4","key":"1009_CR1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1055\/s-0028-1091978","volume":"28","author":"M Lazo","year":"2008","unstructured":"Lazo, M., & Clark, J. M. (2008). The epidemiology of non-alcoholic fatty liver disease: a global perspective. Seminars in Liver Disease, 28(4), 339\u2013350.","journal-title":"Seminars in Liver Disease"},{"issue":"2","key":"1009_CR2","first-page":"76","volume":"25","author":"SP Singh","year":"2004","unstructured":"Singh, S. P., Nayak, S., Swain, M., Rout, N., Mallik, R. N., Agrawal, O., Meher, C., & Rao, M. V. K. (2004). Prevalence of non-alcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey. Tropical Gastroenterology, 25(2), 76\u201379.","journal-title":"Tropical Gastroenterology"},{"issue":"1","key":"1009_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jhep.2015.08.028","volume":"64","author":"U Saran","year":"2016","unstructured":"Saran, U., Humar, B., Kolly, P., & Dufour, J. F. (2016). Hepatocellular carcinoma and lifestyles. Journal of Hepatology, 64(1), 203\u201314.","journal-title":"Journal of Hepatology"},{"issue":"4","key":"1009_CR4","first-page":"303","volume":"114","author":"JJ DiNicolantonio","year":"2017","unstructured":"DiNicolantonio, J. J., & O\u2019Keefe, J. H. (2017). Good fats versus bad fats: a comparison of fatty acids in the promotion of insulin resistance, inflammation, and obesity. Missouri Medicine, 114(4), 303\u2013307.","journal-title":"Missouri Medicine"},{"issue":"4","key":"1009_CR5","first-page":"217","volume":"165","author":"SK Ku","year":"2014","unstructured":"Ku, S. K., Ruhaifi, M. S. M., Fatin, S. S., Saffana, M., Anna, K. T., Das, S., & Kamsiah, J. (2014). The harmful effects of consumption of repeatedly heated edible oils: a short review. La Clinica Terapeutica, 165(4), 217\u201321.","journal-title":"La Clinica Terapeutica"},{"issue":"9","key":"1009_CR6","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1177\/0960327116674530","volume":"36","author":"A Narayanankutty","year":"2017","unstructured":"Narayanankutty, A., Manalil, J. J., Susheela, I. M., Ramavarma, S. K., Mathew, S. E., Illam, S. P., Babu, T. D., Kuzhivelil, B. T., & Raghavamenon, A. C. (2017). Deep-fried edible oil disturb hepatic redox equilibrium, lipotoxicity and hepatosteatosis in male Wistar rats. Human & Experimental Toxicology, 36(9), 919\u2013930.","journal-title":"Human & Experimental Toxicology"},{"issue":"1","key":"1009_CR7","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch, J., Lees, M., & Stanley, C. H. S. (1957). A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry, 226(1), 497\u2013509.","journal-title":"Journal of Biological Chemistry"},{"key":"1009_CR8","first-page":"486","volume":"41","author":"A Zlatkis","year":"1953","unstructured":"Zlatkis, A., Zak, B., & Boyle, A. J. (1953). A new method for the direct determination of serum cholesterol. Journal of Laboratory and Clinical Medicine, 41, 486\u201392.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"1009_CR9","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0021-9258(18)84756-1","volume":"66","author":"CH Fiske","year":"1925","unstructured":"Fiske, C. H., & Subbarow, Y. (1925). The colorimetric determination of phosphorous. Journal of Biological Chemistry, 66, 375\u2013400.","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"1009_CR10","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissue by thiobarbituric acid reactions. Analytical Biochemistry, 95(2), 351\u2013358.","journal-title":"Analytical Biochemistry"},{"issue":"12","key":"1009_CR11","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1021\/ac60205a053","volume":"35","author":"I Bergman","year":"1963","unstructured":"Bergman, I., & Loxle, R. (1963). Two improved and simplified methods for the spectrophotometric determination of hydroxyproline. Analytical Chemistry, 35(12), 1961\u20131965.","journal-title":"Analytical Chemistry"},{"issue":"1","key":"1009_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","volume":"582","author":"MS Moron","year":"1979","unstructured":"Moron, M. S., Depierre, J. W., & Mannervik, B. (1979). Levels of glutathione, glutathione reductase, and glutathione s transferase activities in rat lung and liver. Biochimica et Biophysica Acta, 582(1), 67\u201378.","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"1009_CR13","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/jn\/104.5.580","volume":"104","author":"DG Hafeman","year":"1974","unstructured":"Hafeman, D. G., Sunde, R. A., & Hoekstra, W. G. (1974). Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. Journal of Nutrition, 104(5), 580\u2013587.","journal-title":"Journal of Nutrition"},{"issue":"4","key":"1009_CR14","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0021-9258(19)81737-4","volume":"243","author":"RD Mavis","year":"1968","unstructured":"Mavis, R. D., & Stellwagen, E. (1968). Purification and subunit structure of glutathione reductase from bakers\u2019 yeast. Journal of Biological Chemistry, 243(4), 809\u2013814.","journal-title":"Journal of Biological Chemistry"},{"issue":"22","key":"1009_CR15","doi-asserted-by":"publisher","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","volume":"244","author":"JM McCord","year":"1969","unstructured":"McCord, J. M., & Fridovich, I. (1969). Superoxide dismutase an enzymatic function for erythrocuprein. Journal of Biological Chemistry, 244(22), 6049\u20136055.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"1009_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","volume":"195","author":"RF Beers","year":"1952","unstructured":"Beers, Jr., R. F., & Sizer, I. W. (1952). A spectrophotometric method for the breakdown of hydrogen peroxide by catalase. Journal of Biological Chemistry, 195(1), 133\u2013140.","journal-title":"Journal of Biological Chemistry"},{"issue":"22","key":"1009_CR17","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry, 249(22), 7130\u20139.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"1009_CR18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry, O. H., Rosebrough, N. H., Farr, A. L., & Randal, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193(1), 265\u2013275.","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"1009_CR19","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1042\/bj3130893","volume":"313","author":"M Bergo","year":"1996","unstructured":"Bergo, M., Olivecrona, G., & Olivecrona, T. (1996). Forms of lipoprotein lipase in rat tissues: In adipose tissue, the proportion of inactive lipase increases on fasting. Biochemical Journal, 313(3), 893\u2013898.","journal-title":"Biochemical Journal"},{"issue":"39","key":"1009_CR20","doi-asserted-by":"publisher","first-page":"4436","DOI":"10.3748\/wjg.v24.i39.4436","volume":"24","author":"JM O\u2019Rourke","year":"2018","unstructured":"O\u2019Rourke, J. M., Sagar, V. M., Shah, T., & Shetty, S. (2018). Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer. World Journal of Gastroenterology, 24(39), 4436\u20134447.","journal-title":"World Journal of Gastroenterology"},{"issue":"2","key":"1009_CR21","doi-asserted-by":"publisher","first-page":"G194","DOI":"10.1152\/ajpgi.00413.2005","volume":"290","author":"MW Bradbury","year":"2006","unstructured":"Bradbury, M. W. (2006). Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 290(2), G194\u2013G198.","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"issue":"2","key":"1009_CR22","first-page":"149","volume":"45","author":"I Bruda\u015fc\u0103","year":"2007","unstructured":"Bruda\u015fc\u0103, I., & Cucuianu, M. (2007). Pathogenic role of abnormal fatty acids and adipokines in the portal flow. Relevance for metabolic syndrome, hepatic steatosis, and steatohepatitis. Romanian Journal of Internal Medicine, 45(2), 149\u2013157.","journal-title":"Romanian Journal of Internal Medicine"},{"issue":"6","key":"1009_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald, W. T., Levy, R. I. & Fredrickson, D. S. (1972). Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499\u2013502.","journal-title":"Clinical Chemistry"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-021-01009-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-021-01009-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-021-01009-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T09:41:01Z","timestamp":1635327661000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-021-01009-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1009"],"URL":"https:\/\/doi.org\/10.1007\/s12013-021-01009-5","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"type":"print","value":"1085-9195"},{"type":"electronic","value":"1559-0283"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"28 May 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All experiments involving animals conducted in this study were in accordance with the institution\u2019s ethical standards and had prior permission from the Institutional Animal Ethical Committee that follow the guidelines of CPCSEA, Government of India (approval no: ACRC\/IEAC\/19(1) P-1). The manuscript does not contain any studies involving human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}