{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:52:01Z","timestamp":1787313121602,"version":"build-2736575974"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s12013-021-01012-w","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T05:02:36Z","timestamp":1624770156000},"page":"449-459","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lipid-Derived Mediators are Pivotal to Leukocyte and Lung Cell Responses in Sepsis and ARDS"],"prefix":"10.1007","volume":"79","author":[{"given":"Julie","family":"Nijmeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-5731","authenticated-orcid":false,"given":"Bruce D.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"1012_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","volume":"140","author":"C Nathan","year":"2010","unstructured":"Nathan, C., & Ding, A. (2010). Nonresolving inflammation. Cell, 140, 871\u2013882","journal-title":"Cell"},{"key":"1012_CR2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","volume":"510","author":"CN Serhan","year":"2014","unstructured":"Serhan, C. N. (2014). Pro-resolving lipid mediators are leads for resolution physiology. Nature, 510, 92\u2013101","journal-title":"Nature"},{"key":"1012_CR3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1146\/annurev-physiol-021113-170408","volume":"76","author":"BD Levy","year":"2014","unstructured":"Levy, B. D., & Serhan, C. N. (2014). Resolution of acute inflammation in the lung. Annual Review Physiology, 76, 467\u2013492","journal-title":"Annual Review Physiology"},{"key":"1012_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nri.2015.4","volume":"16","author":"MC Basil","year":"2016","unstructured":"Basil, M. C., & Levy, B. D. (2016). Specialized pro-resolving mediators: Endogenous regulators of infection and inflammation. Nature Review Immunology, 16, 51\u201367","journal-title":"Nature Review Immunology"},{"key":"1012_CR5","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1172\/JCI97943","volume":"128","author":"CN Serhan","year":"2018","unstructured":"Serhan, C. N., & Levy, B. D. (2018). Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators. Journal of Clinical Investigation, 128, 2657\u20132669","journal-title":"Journal of Clinical Investigation"},{"key":"1012_CR6","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1152\/physrev.00026.2017","volume":"98","author":"N Krishnamoorthy","year":"2018","unstructured":"Krishnamoorthy, N., Abdulnour, R. E., Walker, K. H., Engstrom, B. D., & Levy, B. D. (2018). Specialized proresolving mediators in innate and adaptive immune responses in airway diseases. Physiological Reviews, 98, 1335\u20131370","journal-title":"Physiological Reviews"},{"key":"1012_CR7","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1056\/NEJMoa012918","volume":"346","author":"CM Albert","year":"2002","unstructured":"Albert, C. M., et al. (2002). Blood levels of long-chain n-3 fatty acids and the risk of sudden death. The New England Journal of Medicine, 346, 1113\u20131118","journal-title":"The New England Journal of Medicine"},{"key":"1012_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/026010600902000102","volume":"20","author":"C Galli","year":"2009","unstructured":"Galli, C., & Rise, P. (2009). Fish consumption, omega 3 fatty acids and cardiovascular disease. The science and the clinical trials. Nutrition and Health, 20, 11\u201320","journal-title":"Nutrition and Health"},{"key":"1012_CR9","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1056\/NEJMoa1503734","volume":"375","author":"H Bisgaard","year":"2016","unstructured":"Bisgaard, H., et al. (2016). Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. The New England Journal of Medicine, 375, 2530\u20132539","journal-title":"The New England Journal of Medicine"},{"key":"1012_CR10","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1056\/NEJMclde1614333","volume":"375","author":"R Ramaswami","year":"2016","unstructured":"Ramaswami, R., Serhan, C. N., Levy, B. D., & Makrides, M. (2016). Fish oil supplementation in pregnancy. The New England Journal of Medicine, 375, 2599\u20132601","journal-title":"The New England Journal of Medicine"},{"key":"1012_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1172\/JCI82224","volume":"126","author":"MJ Delano","year":"2016","unstructured":"Delano, M. J., & Ward, P. A. (2016). Sepsis-induced immune dysfunction: Can immune therapies reduce mortality? Journal of Clinical Investigation, 126, 23\u201331","journal-title":"Journal of Clinical Investigation"},{"key":"1012_CR12","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1111\/jcmm.13112","volume":"21","author":"XF Shen","year":"2017","unstructured":"Shen, X. F., Cao, K., Jiang, J. P., Guan, W. X., & Du, J. F. (2017). Neutrophil dysregulation during sepsis: An overview and update. Journal of Cellular and Molecular Medicine, 21, 1687\u20131697","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"1012_CR13","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer, M., et al. (2016). The Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 315, 801\u2013810","journal-title":"JAMA"},{"key":"1012_CR14","doi-asserted-by":"publisher","first-page":"F1000 Faculty R","DOI":"10.12688\/f1000research.7646.1","volume":"5","author":"RM Baron","year":"2016","unstructured":"Baron, R. M., & Levy, B. D. (2016). Recent advances in understanding and treating ARDS. F1000Res, 5, F1000 Faculty Rev-725","journal-title":"F1000Res"},{"key":"1012_CR15","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1056\/NEJM198902093200606","volume":"320","author":"SJ Weiss","year":"1989","unstructured":"Weiss, S. J. (1989). Tissue destruction by neutrophils. The New England Journal of Medicine, 320, 365\u2013376","journal-title":"The New England Journal of Medicine"},{"key":"1012_CR16","unstructured":"Majno, G., & Joris, I. (2004). In Cells, tissues, and disease: Principles of general pathology (chap. 8, 2nd, ed.). Oxford University Press, 307-332"},{"key":"1012_CR17","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/nature08541","volume":"461","author":"M Spite","year":"2009","unstructured":"Spite, M., et al. (2009). Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature, 461, 1287\u20131291","journal-title":"Nature"},{"key":"1012_CR18","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.1039\/C6LC00940A","volume":"16","author":"JL Prieto","year":"2016","unstructured":"Prieto, J. L., et al. (2016). Monitoring sepsis using electrical cell profiling. Lab on a Chip, 16, 4333\u20134340","journal-title":"Lab on a Chip"},{"key":"1012_CR19","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/s41551-019-0473-5","volume":"3","author":"B Jundi","year":"2019","unstructured":"Jundi, B., et al. (2019). Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity. Nature Biomedical Engineering, 3, 961\u2013973","journal-title":"Nature Biomedical Engineering"},{"key":"1012_CR20","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.cell.2010.02.043","volume":"140","author":"CA Dinarello","year":"2010","unstructured":"Dinarello, C. A. (2010). Anti-inflammatory agents: Present and future. Cell, 140, 935\u2013950","journal-title":"Cell"},{"key":"1012_CR21","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.4049\/jimmunol.174.8.5033","volume":"174","author":"K Fukunaga","year":"2005","unstructured":"Fukunaga, K., Kohli, P., Bonnans, C., Fredenburgh, L. E., & Levy, B. D. (2005). Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. The Journal of Immunology, 174, 5033\u20135039","journal-title":"The Journal of Immunology"},{"key":"1012_CR22","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/mi.2012.66","volume":"6","author":"O Eickmeier","year":"2013","unstructured":"Eickmeier, O., et al. (2013). Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury. Mucosal Immunology, 6, 256\u2013266","journal-title":"Mucosal Immunology"},{"key":"1012_CR23","doi-asserted-by":"publisher","first-page":"16526","DOI":"10.1073\/pnas.1407123111","volume":"111","author":"RE Abdulnour","year":"2014","unstructured":"Abdulnour, R. E., et al. (2014). Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proceedings of the National Academy of Sciences of the United States of America, 111, 16526\u201316531","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"1012_CR24","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1097\/CCM.0000000000002014","volume":"45","author":"J Dalli","year":"2017","unstructured":"Dalli, J., et al. (2017). Human sepsis eicosanoid and proresolving lipid mediator temporal profiles: Correlations with survival and clinical outcomes. Critical Care Medicine, 45, 58\u201368","journal-title":"Critical Care Medicine"},{"key":"1012_CR25","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000241","volume":"2","author":"P Tejera","year":"2020","unstructured":"Tejera, P., et al. (2020). Plasma levels of proresolving and prophlogistic lipid mediators: Association with severity of respiratory failure and mortality in acute respiratory distress syndrome. Critical Care Explorations, 2, e0241","journal-title":"Critical Care Explorations"},{"key":"1012_CR26","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1164\/rccm.201712-2530OC","volume":"197","author":"RE Abdulnour","year":"2018","unstructured":"Abdulnour, R. E., et al. (2018). Early intravascular events are associated with development of acute respiratory distress syndrome. A substudy of the LIPS-A clinical trial. American Journal of Respiratory and Critical Care Medicine, 197, 1575\u20131585","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1012_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.blre.2006.06.001","volume":"21","author":"A Zarbock","year":"2007","unstructured":"Zarbock, A., Polanowska-Grabowska, R. K., & Ley, K. (2007). Platelet-neutrophil-interactions: linking hemostasis and inflammation. Blood Reviews, 21, 99\u2013111","journal-title":"Blood Reviews"},{"key":"1012_CR28","first-page":"3450","volume":"119","author":"MR Looney","year":"2009","unstructured":"Looney, M. R., et al. (2009). Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. Journal of Clinical Investigation, 119, 3450\u20133461","journal-title":"Journal of Clinical Investigation"},{"key":"1012_CR29","doi-asserted-by":"publisher","first-page":"9475","DOI":"10.1073\/pnas.92.21.9475","volume":"92","author":"J Claria","year":"1995","unstructured":"Claria, J., & Serhan, C. N. (1995). Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proceedings of the National Academy of Sciences of the United States of America, 92, 9475\u20139479","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"1012_CR30","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1164\/rccm.201403-0544OC","volume":"190","author":"E Ono","year":"2014","unstructured":"Ono, E., et al. (2014). Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. American Journal of Respiratory and Critical Care Medicine, 190, 886\u2013897","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1012_CR31","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1164\/rccm.201801-0139WS","volume":"198","author":"CS Dela Cruz","year":"2018","unstructured":"Dela Cruz, C. S., et al. (2018). Future research directions in pneumonia. NHLBI working group report. American Journal of Respiratory Critical Care Medicine, 198, 256\u2013263","journal-title":"American Journal of Respiratory Critical Care Medicine"},{"key":"1012_CR32","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1165\/rcmb.2009-0047TR","volume":"43","author":"G Balamayooran","year":"2010","unstructured":"Balamayooran, G., Batra, S., Fessler, M. B., Happel, K. I., & Jeyaseelan, S. (2010). Mechanisms of neutrophil accumulation in the lungs against bacteria. American Journal of Respiratory Cell and Molecular Biology, 43, 5\u201316","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"1012_CR33","doi-asserted-by":"publisher","first-page":"836","DOI":"10.4049\/jimmunol.0901809","volume":"184","author":"H Seki","year":"2010","unstructured":"Seki, H., et al. (2010). The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. Journal of Immunology, 184, 836\u2013843","journal-title":"Journal of Immunology"},{"key":"1012_CR34","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1073\/pnas.1610242114","volume":"114","author":"BA Flitter","year":"2017","unstructured":"Flitter, B. A., et al. (2017). Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proceedings of the National Academy of Sciences of United States of America, 114, 136\u2013141","journal-title":"Proceedings of the National Academy of Sciences of United States of America"},{"key":"1012_CR35","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nm.2715","volume":"18","author":"TS Cohen","year":"2012","unstructured":"Cohen, T. S., & Prince, A. (2012). Cystic fibrosis: a mucosal immunodeficiency syndrome. Nature Medicine, 18, 509\u2013519","journal-title":"Nature Medicine"},{"key":"1012_CR36","doi-asserted-by":"publisher","first-page":"L150","DOI":"10.1152\/ajplung.00383.2017","volume":"314","author":"KL Hvorecny","year":"2018","unstructured":"Hvorecny, K. L., et al. (2018). An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung. American Journal of Physiology Lung Cellular and Molecular Physiology, 314, L150\u2013L156","journal-title":"American Journal of Physiology Lung Cellular and Molecular Physiology"},{"key":"1012_CR37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1164\/ajrccm.151.2.7842182","volume":"151","author":"LD Hudson","year":"1995","unstructured":"Hudson, L. D., Milberg, J. A., Anardi, D., & Maunder, R. J. (1995). Clinical risks for development of the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 151, 293\u2013301","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1012_CR38","doi-asserted-by":"publisher","unstructured":"Tavares, A. H., Colby, J. K., Levy, B. D., & Abdulnour, R. E. (2019). A model of self-limited acute lung injury by unilateral intra-bronchial acid instillation. Journal of Visualized Experiments, https:\/\/doi.org\/10.3791\/60024","DOI":"10.3791\/60024"},{"key":"1012_CR39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.plefa.2010.09.002","volume":"84","author":"BD Levy","year":"2011","unstructured":"Levy, B. D., et al. (2011). The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins, Leukotrienes & Essential Fatty Acids, 84, 43\u201350","journal-title":"Prostaglandins, Leukotrienes & Essential Fatty Acids"},{"key":"1012_CR40","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nm.2847","volume":"18","author":"BG Yipp","year":"2012","unstructured":"Yipp, B. G., et al. (2012). Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nature Medicine, 18, 1386\u20131393","journal-title":"Nature Medicine"},{"key":"1012_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76781-0","volume":"10","author":"A Arcanjo","year":"2020","unstructured":"Arcanjo, A., et al. (2020). The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19). Scientific Reports, 10, 19630","journal-title":"Scientific Reports"},{"key":"1012_CR42","doi-asserted-by":"publisher","first-page":"eaao4747","DOI":"10.1126\/sciimmunol.aao4747","volume":"3","author":"N Krishnamoorthy","year":"2018","unstructured":"Krishnamoorthy, N., et al. (2018). Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Science Immunology, 3, eaao4747","journal-title":"Science Immunology"},{"key":"1012_CR43","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1164\/rccm.201810-1869OC","volume":"199","author":"ME Lachowicz-Scroggins","year":"2019","unstructured":"Lachowicz-Scroggins, M. E., et al. (2019). Extracellular DNA, neutrophil extracellular traps, and inflammasome activation in severe asthma. American Journal of Respiratory and Critical Care Medicine, 199, 1076\u20131085","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1012_CR44","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/89759","volume":"2","author":"BD Levy","year":"2001","unstructured":"Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001). Lipid mediator class switching during acute inflammation: signals in resolution. Nature Immunology, 2, 612\u2013619","journal-title":"Nature Immunology"},{"key":"1012_CR45","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1038\/mi.2015.129","volume":"9","author":"RE Abdulnour","year":"2016","unstructured":"Abdulnour, R. E., et al. (2016). Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. Mucosal Immunology, 9, 1278\u20131287","journal-title":"Mucosal Immunology"},{"key":"1012_CR46","doi-asserted-by":"publisher","first-page":"eaar8320","DOI":"10.1126\/sciadv.aar8320","volume":"4","author":"CA Loynes","year":"2018","unstructured":"Loynes, C. A., et al. (2018). PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Science Advances, 4, eaar8320","journal-title":"Science Advances"},{"key":"1012_CR47","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.4049\/jimmunol.1602090","volume":"200","author":"HP Sham","year":"2018","unstructured":"Sham, H. P., et al. (2018). 15-epi-Lipoxin A4, resolvin D2, and resolvin D3 induce NF-kappaB regulators in bacterial pneumonia. Journal of Immunology, 200, 2757\u20132766","journal-title":"Journal of Immunology"},{"key":"1012_CR48","doi-asserted-by":"publisher","first-page":"875","DOI":"10.4049\/jimmunol.1500244","volume":"195","author":"X Fang","year":"2015","unstructured":"Fang, X., et al. (2015). Human mesenchymal stem (stromal) cells promote the resolution of acute lung injury in part through lipoxin A4. Journal of Immunology, 195, 875\u2013881","journal-title":"Journal of Immunology"},{"key":"1012_CR49","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1126\/science.2820055","volume":"237","author":"B Samuelsson","year":"1987","unstructured":"Samuelsson, B., Dahlen, S. E., Lindgren, J. A., Rouzer, C. A., & Serhan, C. N. (1987). Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science, 237, 1171\u20131176","journal-title":"Science"},{"key":"1012_CR50","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/40180","volume":"389","author":"BD Levy","year":"1997","unstructured":"Levy, B. D., Petasis, N. A., & Serhan, C. N. (1997). Polyisoprenyl phosphates in intracellular signalling. Nature, 389, 985\u2013990","journal-title":"Nature"},{"key":"1012_CR51","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1096\/fasebj.13.8.903","volume":"13","author":"BD Levy","year":"1999","unstructured":"Levy, B. D., et al. (1999). Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a \u2018stop\u2019 signaling switch for aspirin-triggered lipoxin A4. The FASEB Journal, 13, 903\u2013911","journal-title":"The FASEB Journal"},{"key":"1012_CR52","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/sj.bjp.0706338","volume":"146","author":"BD Levy","year":"2005","unstructured":"Levy, B. D., et al. (2005). Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. British Journal of Pharmacology, 146, 344\u2013351","journal-title":"British Journal of Pharmacology"},{"key":"1012_CR53","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1084\/jem.20052143","volume":"203","author":"C Bonnans","year":"2006","unstructured":"Bonnans, C., Fukunaga, K., Keledjian, R., Petasis, N. A., & Levy, B. D. (2006). Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury. Journal of Experimental Medicine, 203, 857\u2013863","journal-title":"Journal of Experimental Medicine"},{"key":"1012_CR54","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1096\/fj.12-223982","volume":"27","author":"T Carlo","year":"2013","unstructured":"Carlo, T., Kalwa, H., & Levy, B. D. (2013). 15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1. The FASEB Journal, 27, 2733\u20132741","journal-title":"The FASEB Journal"},{"key":"1012_CR55","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1021\/bi8020636","volume":"48","author":"T Carlo","year":"2009","unstructured":"Carlo, T., Petasis, N. A., & Levy, B. D. (2009). Activation of polyisoprenyl diphosphate phosphatase 1 remodels cellular presqualene diphosphate. Biochemistry, 48, 2997\u20133004","journal-title":"Biochemistry"},{"key":"1012_CR56","doi-asserted-by":"publisher","first-page":"9490","DOI":"10.1074\/jbc.M512970200","volume":"281","author":"K Fukunaga","year":"2006","unstructured":"Fukunaga, K., et al. (2006). Identification and functional characterization of a presqualene diphosphate phosphatase. Journal of Biological Chemistry, 281, 9490\u20139497","journal-title":"Journal of Biological Chemistry"},{"key":"1012_CR57","doi-asserted-by":"publisher","first-page":"13918","DOI":"10.1074\/jbc.M109.083931","volume":"285","author":"S Miriyala","year":"2010","unstructured":"Miriyala, S., et al. (2010). Functional characterization of the atypical integral membrane lipid phosphatase PDP1\/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. Journal of Biology Chemistry, 285, 13918\u201313929","journal-title":"Journal of Biology Chemistry"},{"key":"1012_CR58","doi-asserted-by":"publisher","first-page":"299","DOI":"10.2332\/allergolint.08-RAI-0018","volume":"57","author":"T Carlo","year":"2008","unstructured":"Carlo, T., & Levy, B. D. (2008). Chemical mediators and the resolution of airway inflammation. Allergology International, 57, 299\u2013305","journal-title":"Allergology International"},{"key":"1012_CR59","doi-asserted-by":"publisher","first-page":"30227","DOI":"10.1074\/jbc.M111078200","volume":"277","author":"RJ Cummings","year":"2002","unstructured":"Cummings, R. J., et al. (2002). Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. Journal of Biology Chemistry, 277, 30227\u201330235","journal-title":"Journal of Biology Chemistry"},{"key":"1012_CR60","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","volume":"6","author":"RJ Hewitt","year":"2021","unstructured":"Hewitt, R. J. & Lloyd, C. M. (2021). Regulation of immune responses by the airway epithelial cell landscape. Nature Review Immunology, 6, 347\u2013362","journal-title":"Nature Review Immunology"},{"key":"1012_CR61","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1002\/JLB.3A0617-252RR","volume":"103","author":"RE Abdulnour","year":"2018","unstructured":"Abdulnour, R. E., et al. (2018). Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury. Journal of Leukocyte Biology, 103, 919\u2013932","journal-title":"Journal of Leukocyte Biology"},{"key":"1012_CR62","doi-asserted-by":"publisher","first-page":"4553","DOI":"10.1128\/iai.61.11.4553-4559.1993","volume":"61","author":"S Chollet-Martin","year":"1993","unstructured":"Chollet-Martin, S., et al. (1993). High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome. Infection and Immunity, 61, 4553\u20134559","journal-title":"Infection and Immunity"},{"key":"1012_CR63","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1165\/ajrcmb.11.2.8049083","volume":"11","author":"V Natarajan","year":"1994","unstructured":"Natarajan, V., Jayaram, H. N., Scribner, W. M., & Garcia, J. G. (1994). Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. American Journal of Respiratory Cell and Molecular Biology, 11, 221\u2013229","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"1012_CR64","doi-asserted-by":"publisher","first-page":"107828","DOI":"10.1016\/j.celrep.2020.107828","volume":"31","author":"Q Chen","year":"2020","unstructured":"Chen, Q., et al. (2020). Angiocrine sphingosine-1-phosphate activation of S1PR2-YAP signaling axis in alveolar type II cells is essential for lung repair. Cell Reports, 31, 107828","journal-title":"Cell Reports"},{"key":"1012_CR65","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3390\/antiox10030477","volume":"10","author":"P Fu","year":"2021","unstructured":"Fu, P., et al. (2021). NOX4 mediates pseudomonas aeruginosa-induced nuclear reactive oxygen species generation and chromatin remodeling in lung epithelium. Antioxidants (Basel), 10, 477","journal-title":"Antioxidants (Basel)"},{"key":"1012_CR66","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/ijms19010114","volume":"19","author":"V Suryadevara","year":"2018","unstructured":"Suryadevara, V., et al. (2018). Sphingolipids in ventilator induced lung injury: role of sphingosine-1-phosphate lyase. International Journal of Molecular Sciences, 19, 114","journal-title":"International Journal of Molecular Sciences"},{"key":"1012_CR67","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.3390\/ijms21124257","volume":"21","author":"V Suryadevara","year":"2020","unstructured":"Suryadevara, V., Ramchandran, R., Kamp, D. W. & Natarajan, V. (2020). Lipid mediators regulate pulmonary fibrosis: potential mechanisms and signaling pathways. International Journal of Molecular Sciences, 21, 4257","journal-title":"International Journal of Molecular Sciences"},{"key":"1012_CR68","doi-asserted-by":"publisher","first-page":"158681","DOI":"10.1016\/j.bbalip.2020.158681","volume":"1865","author":"DL Ebenezer","year":"2020","unstructured":"Ebenezer, D. L., et al. (2020). S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1865, 158681","journal-title":"Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids"},{"key":"1012_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-6367-9","volume":"20","author":"DL Ebenezer","year":"2019","unstructured":"Ebenezer, D. L., et al. (2019). Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung. BMC Genomics, 20, 984","journal-title":"BMC Genomics"},{"key":"1012_CR70","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jbior.2016.09.007","volume":"63","author":"DL Ebenezer","year":"2017","unstructured":"Ebenezer, D. L., Fu, P., Suryadevara, V., Zhao, Y., & Natarajan, V. (2017). Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. Advances in Biological Regulation, 63, 156\u2013166","journal-title":"Advances in Biological Regulation"},{"key":"1012_CR71","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.pharmthera.2016.09.008","volume":"168","author":"DL Ebenezer","year":"2016","unstructured":"Ebenezer, D. L., Fu, P., & Natarajan, V. (2016). Targeting sphingosine-1-phosphate signaling in lung diseases. Pharmacology and Therapeutics, 168, 143\u2013157","journal-title":"Pharmacology and Therapeutics"},{"key":"1012_CR72","doi-asserted-by":"publisher","first-page":"108","DOI":"10.4103\/2045-8932.109925","volume":"3","author":"PV Usatyuk","year":"2013","unstructured":"Usatyuk, P. V., Kotha, S. R., Parinandi, N. L., & Natarajan, V. (2013). Phospholipase D signaling mediates reactive oxygen species-induced lung endothelial barrier dysfunction. Pulmonary Circulation, 3, 108\u2013115","journal-title":"Pulmonary Circulation"},{"key":"1012_CR73","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1165\/rcmb.2006-0269TR","volume":"36","author":"C Bonnans","year":"2007","unstructured":"Bonnans, C., & Levy, B. D. (2007). Lipid mediators as agonists for the resolution of acute lung inflammation and injury. American Journal of Respiratory Cell and Molecular Biology, 36, 201\u2013205","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"1012_CR74","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1034\/j.1399-3003.2000.16a08.x","volume":"16","author":"M Sanak","year":"2000","unstructured":"Sanak, M., et al. (2000). Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. European Respiratory Journal, 16, 44\u201349","journal-title":"European Respiratory Journal"},{"key":"1012_CR75","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1164\/rccm.200410-1413OC","volume":"172","author":"BD Levy","year":"2005","unstructured":"Levy, B. D., et al. (2005). Diminished lipoxin biosynthesis in severe asthma. American Journal of Respiratory and Critical Care Medicine, 172, 824\u2013830","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"1012_CR76","doi-asserted-by":"publisher","first-page":"174ra126","DOI":"10.1126\/scitranslmed.3004812","volume":"5","author":"C Barnig","year":"2013","unstructured":"Barnig, C., et al. (2013). Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Science Translational Medicine, 5, 174ra126","journal-title":"Science Translational Medicine"},{"key":"1012_CR77","doi-asserted-by":"publisher","DOI":"10.5936\/csbj.201303018","volume":"6","author":"V Urbach","year":"2013","unstructured":"Urbach, V., Higgins, G., Buchanan, P., & Ringholz, F. (2013). The role of Lipoxin A4 in cystic fibrosis lung disease. Computational Structural Biotechnology Journal, 6, e201303018","journal-title":"Computational Structural Biotechnology Journal"},{"key":"1012_CR78","first-page":"1548","volume":"6","author":"S Bozinovski","year":"2014","unstructured":"Bozinovski, S., Anthony, D., & Vlahos, R. (2014). Targeting pro-resolution pathways to combat chronic inflammation in COPD. Journal of Thoracic Disease, 6, 1548\u20131556","journal-title":"Journal of Thoracic Disease"},{"key":"1012_CR79","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1213\/01.ane.0000252414.00363.c4","volume":"104","author":"SW Jin","year":"2007","unstructured":"Jin, S. W., et al. (2007). Posttreatment with aspirin-triggered lipoxin A4 analog attenuates lipopolysaccharide-induced acute lung injury in mice: the role of heme oxygenase-1. Anesthesia and Analgesia, 104, 369\u2013377","journal-title":"Anesthesia and Analgesia"},{"key":"1012_CR80","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/ni.1627","volume":"9","author":"O Haworth","year":"2008","unstructured":"Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., & Levy, B. D. (2008). Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nature Immunology, 9, 873\u2013879","journal-title":"Nature Immunology"},{"key":"1012_CR81","doi-asserted-by":"publisher","first-page":"14983","DOI":"10.1073\/pnas.1206641109","volume":"109","author":"D El Kebir","year":"2012","unstructured":"El Kebir, D., Gjorstrup, P., & Filep, J. G. (2012). Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Proceedings of the National Academy Sciences of United States of America, 109, 14983\u201314988","journal-title":"Proceedings of the National Academy Sciences of United States of America"},{"key":"1012_CR82","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1517\/14728220902865622","volume":"13","author":"T Hisada","year":"2009","unstructured":"Hisada, T., Ishizuka, T., Aoki, H., & Mori, M. (2009). Resolvin E1 as a novel agent for the treatment of asthma. Expert Opinion on Therapeutic Targets, 13, 513\u2013522","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"1012_CR83","first-page":"6254587","volume":"2019","author":"H Xia","year":"2019","unstructured":"Xia, H., et al. (2019). Resolvin D1 alleviates ventilator-induced lung injury in mice by activating PPARgamma\/NF-kappaB signaling pathway. Biomed Research International, 2019, 6254587","journal-title":"Biomed Research International"},{"key":"1012_CR84","doi-asserted-by":"publisher","first-page":"105877","DOI":"10.1016\/j.intimp.2019.105877","volume":"76","author":"HW Zhang","year":"2019","unstructured":"Zhang, H. W., et al. (2019). RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar macrophages. International Immunopharmacology, 76, 105877","journal-title":"International Immunopharmacology"},{"key":"1012_CR85","doi-asserted-by":"publisher","first-page":"842","DOI":"10.4049\/jimmunol.1601650","volume":"198","author":"N Chiang","year":"2017","unstructured":"Chiang, N., de la Rosa, X., Libreros, S., & Serhan, C. N. (2017). Novel resolvin D2 receptor axis in infectious inflammation. Journal of Immunology, 198, 842\u2013851","journal-title":"Journal of Immunology"},{"key":"1012_CR86","doi-asserted-by":"publisher","first-page":"496","DOI":"10.4049\/jimmunol.178.1.496","volume":"178","author":"BD Levy","year":"2007","unstructured":"Levy, B. D., et al. (2007). Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. Journal of Immunology, 178, 496\u2013502","journal-title":"Journal of Immunology"},{"key":"1012_CR87","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.jaci.2012.07.048","volume":"131","author":"J Miyata","year":"2013","unstructured":"Miyata, J., et al. (2013). Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. The Journal of Allergy Clinical Immunology, 131, 353\u2013360","journal-title":"The Journal of Allergy Clinical Immunology"},{"key":"1012_CR88","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3760\/cma.j.issn.0366-6999.20131104","volume":"127","author":"X Li","year":"2014","unstructured":"Li, X., et al. (2014). Protectin D1 promotes resolution of inflammation in a murine model of lipopolysaccharide-induced acute lung injury via enhancing neutrophil apoptosis. Chinese Medical Journal, 127, 810\u2013814","journal-title":"Chinese Medical Journal"},{"key":"1012_CR89","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1056\/NEJMoa021218","volume":"350","author":"SD Freedman","year":"2004","unstructured":"Freedman, S. D., et al. (2004). Association of cystic fibrosis with abnormalities in fatty acid metabolism. The New England Journal of Medicine, 350, 560\u2013569","journal-title":"The New England Journal of Medicine"},{"key":"1012_CR90","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1084\/jem.20081880","volume":"206","author":"CN Serhan","year":"2009","unstructured":"Serhan, C. N., et al. (2009). Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. Journal of Experimental Medicine, 206, 15\u201323","journal-title":"Journal of Experimental Medicine"},{"key":"1012_CR91","doi-asserted-by":"publisher","first-page":"4131420","DOI":"10.1155\/2021\/4131420","volume":"2021","author":"G Ou","year":"2021","unstructured":"Ou, G., et al. (2021). The protective effects of Maresin 1 in the OVA-induced asthma mouse model. Mediators of Inflammation, 2021, 4131420","journal-title":"Mediators of Inflammation"},{"key":"1012_CR92","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.jss.2020.06.062","volume":"256","author":"N Qiao","year":"2020","unstructured":"Qiao, N., et al. (2020). Maresin1 promotes M2 macrophage polarization through peroxisome proliferator-activated receptor-gamma activation to expedite resolution of acute lung injury. Journal of Surgical Research, 256, 584\u2013594","journal-title":"Journal of Surgical Research"},{"key":"1012_CR93","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.trsl.2015.01.001","volume":"166","author":"TM Nordgren","year":"2015","unstructured":"Nordgren, T. M., et al. (2015). Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Translational Research, 166, 57\u201369","journal-title":"Translational Research"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-021-01012-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-021-01012-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-021-01012-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T15:09:24Z","timestamp":1725289764000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-021-01012-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,27]]},"references-count":93,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["1012"],"URL":"https:\/\/doi.org\/10.1007\/s12013-021-01012-w","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,27]]},"assertion":[{"value":"24 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"B.D.L. is an inventor on patents (SPMs) assigned to Brigham and Women\u2019s Hospital. J.N. has no conflicts of interest to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}