{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T10:49:40Z","timestamp":1753181380092},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s12013-024-01275-z","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T09:02:06Z","timestamp":1714640526000},"page":"1235-1242","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells"],"prefix":"10.1007","volume":"82","author":[{"given":"G.","family":"Tamizh Selvan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Venkatachalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"issue":"2","key":"1275_CR1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","volume":"40","author":"A Ciccia","year":"2010","unstructured":"Ciccia, A., & Elledge, S. J. (2010). The DNA damage response: making it safe to play with knives. Molecular Cell, 40(2), 179\u2013204. https:\/\/doi.org\/10.1016\/j.molcel.2010.09.019.","journal-title":"Molecular Cell"},{"issue":"7267","key":"1275_CR2","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08467","volume":"461","author":"SP Jackson","year":"2009","unstructured":"Jackson, S. P., & Bartek, J. (2009). The DNA-damage response in human biology and disease. Nature, 461(7267), 1071\u20131078. https:\/\/doi.org\/10.1038\/nature08467.","journal-title":"Nature"},{"issue":"6","key":"1275_CR3","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/em.21791","volume":"54","author":"C Garm","year":"2013","unstructured":"Garm, C., Moreno-Villanueva, M., B\u00fcrkle, A., Larsen, L. A., Bohr, V. A., Christensen, K., & Stevnsner, T. (2013). Genetic and environmental influence on DNA strand break repair: a twin study. Environmental and Molecular Mutagenesis, 54(6), 414\u2013420. https:\/\/doi.org\/10.1002\/em.21791.","journal-title":"Environmental and Molecular Mutagenesis"},{"issue":"4","key":"1275_CR4","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.cell.2017.01.002","volume":"168","author":"A Tubbs","year":"2017","unstructured":"Tubbs, A., & Nussenzweig, A. (2017). Endogenous DNA Damage as a Source of Genomic Instability in Cancer. Cell, 168(4), 644\u2013656. https:\/\/doi.org\/10.1016\/j.cell.2017.01.002.","journal-title":"Cell"},{"issue":"1","key":"1275_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.molcel.2015.08.020","volume":"60","author":"LB Pontel","year":"2015","unstructured":"Pontel, L. B., Rosado, I. V., Burgos-Barragan, G., Garaycoechea, J. I., Yu, R., Arends, M. J., & Patel, K. J. (2015). Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen. Molecular Cell, 60(1), 177\u2013188. https:\/\/doi.org\/10.1016\/j.molcel.2015.08.020.","journal-title":"Molecular Cell"},{"issue":"2","key":"1275_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3109\/09553002.2012.726397","volume":"89","author":"M Chinnadurai","year":"2013","unstructured":"Chinnadurai, M., Paul, S. F. D., & Venkatachalam, P. (2013). The effect of growth architecture on the induction and decay of bleomycin and X-ray-induced bystander response and genomic instability in lung adenocarcinoma cells and blood lymphocytes. International Journal of Radiation Biology, 89(2), 69\u201378. https:\/\/doi.org\/10.3109\/09553002.2012.726397.","journal-title":"International Journal of Radiation Biology"},{"issue":"3","key":"1275_CR7","doi-asserted-by":"publisher","first-page":"498","DOI":"10.2203\/dose-response.13-060.Selvan","volume":"12","author":"GT Selvan","year":"2014","unstructured":"Selvan, G. T., Bhavani, M., Vijayalakshmi, J., Solomon, F. D. P., Chaudhury, N. K. & & Venkatachalam, P. (2014). Delayed Mitogenic Stimulation Decreases DNA Damage Assessed by Micronucleus Assay in Human Peripheral Blood Lymphocytes after 60 CO Irradiation. Dose-Response, 12(3), 498\u2013508. https:\/\/doi.org\/10.2203\/dose-response.13-060.Selvan.","journal-title":"Dose-Response"},{"issue":"12","key":"1275_CR8","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1002\/cyto.a.22729","volume":"87","author":"R Venkateswarlu","year":"2015","unstructured":"Venkateswarlu, R., Tamizh, S. G., Bhavani, M., Kumar, A., Alok, A., Karthik, K., & Venkatachalam, P. (2015). Mean frequency and relative fluorescence intensity measurement of \u03b3-H2AX foci dose response in PBL exposed to \u03b3-irradiation: An inter- and intra-laboratory comparison and its relevance for radiation triage. Cytometry. Part A: The Journal of the International Society for Analytical Cytology, 87(12), 1138\u20131146. https:\/\/doi.org\/10.1002\/cyto.a.22729.","journal-title":"Cytometry. Part A: The Journal of the International Society for Analytical Cytology"},{"issue":"6","key":"1275_CR9","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","volume":"66","author":"AN Blackford","year":"2017","unstructured":"Blackford, A. N., & Jackson, S. P. (2017). ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response. Molecular Cell, 66(6), 801\u2013817. https:\/\/doi.org\/10.1016\/j.molcel.2017.05.015.","journal-title":"Molecular Cell"},{"issue":"4","key":"1275_CR10","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1158\/0008-5472.CAN-17-3103","volume":"79","author":"JA Torok","year":"2019","unstructured":"Torok, J. A., Oh, P., Castle, K. D., Reinsvold, M., Ma, Y., Luo, L., & Kirsch, D. G. (2019). Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. Cancer Research, 79(4), 773\u2013782. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-3103.","journal-title":"Cancer Research"},{"issue":"2","key":"1275_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1158\/2159-8290.CD-15-0402","volume":"6","author":"NJ Roberts","year":"2016","unstructured":"Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., & Klein, A. P. (2016). Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discovery, 6(2), 166\u2013175. https:\/\/doi.org\/10.1158\/2159-8290.CD-15-0402.","journal-title":"Cancer Discovery"},{"issue":"1","key":"1275_CR12","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nrg3345","volume":"14","author":"M Papamichos-Chronakis","year":"2013","unstructured":"Papamichos-Chronakis, M., & Peterson, C. L. (2013). Chromatin and the genome integrity network. Nature Reviews. Genetics, 14(1), 62\u201375. https:\/\/doi.org\/10.1038\/nrg3345.","journal-title":"Nature Reviews. Genetics"},{"key":"1275_CR13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.coi.2017.11.004","volume":"50","author":"R Dhanwani","year":"2018","unstructured":"Dhanwani, R., Takahashi, M., & Sharma, S. (2018). Cytosolic sensing of immuno-stimulatory DNA, the enemy within. Current Opinion in Immunology, 50, 82\u201387. https:\/\/doi.org\/10.1016\/j.coi.2017.11.004.","journal-title":"Current Opinion in Immunology"},{"issue":"4","key":"1275_CR14","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.molcel.2015.10.040","volume":"60","author":"MJ O\u2019Connor","year":"2015","unstructured":"O\u2019Connor, M. J. (2015). Targeting the DNA Damage Response in Cancer. Molecular Cell, 60(4), 547\u2013560. https:\/\/doi.org\/10.1016\/j.molcel.2015.10.040.","journal-title":"Molecular Cell"},{"issue":"2","key":"1275_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","volume":"16","author":"PG Pili\u00e9","year":"2019","unstructured":"Pili\u00e9, P. G., Tang, C., Mills, G. B., & Yap, T. A. (2019). State-of-the-art strategies for targeting the DNA damage response in cancer. Nature Reviews. Clinical Oncology, 16(2), 81\u2013104. https:\/\/doi.org\/10.1038\/s41571-018-0114-z.","journal-title":"Nature Reviews. Clinical Oncology"},{"issue":"2","key":"1275_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1053\/SRAO00400068","volume":"4","author":"SM Bentzen","year":"1994","unstructured":"Bentzen, S. M., & Overgaard, J. (1994). Patient-to-Patient Variability in the Expression of Radiation-Induced Normal Tissue Injury. Seminars in Radiation Oncology, 4(2), 68\u201380. https:\/\/doi.org\/10.1053\/SRAO00400068.","journal-title":"Seminars in Radiation Oncology"},{"issue":"10","key":"1275_CR17","doi-asserted-by":"publisher","first-page":"e47185","DOI":"10.1371\/journal.pone.0047185","volume":"7","author":"B Greve","year":"2012","unstructured":"Greve, B., B\u00f6lling, T., Amler, S., R\u00f6ssler, U., Gomolka, M., Mayer, C., & Schmezer, P. (2012). Evaluation of different biomarkers to predict individual radiosensitivity in an inter-laboratory comparison\u2013lessons for future studies. PloS One, 7(10), e47185 https:\/\/doi.org\/10.1371\/journal.pone.0047185.","journal-title":"PloS One"},{"issue":"5","key":"1275_CR18","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell, 144(5), 646\u2013674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013.","journal-title":"Cell"},{"issue":"3\u20134","key":"1275_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1269\/jrr.0628","volume":"47","author":"Y Kataoka","year":"2006","unstructured":"Kataoka, Y., Bindokas, V. P., Duggan, R. C., Murley, J. S., & Grdina, D. J. (2006). Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells. Journal of Radiation Research, 47(3\u20134), 245\u2013257. https:\/\/doi.org\/10.1269\/jrr.0628.","journal-title":"Journal of Radiation Research"},{"issue":"5","key":"1275_CR20","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/nprot.2007.77","volume":"2","author":"M Fenech","year":"2007","unstructured":"Fenech, M. (2007). Cytokinesis-block micronucleus cytome assay. Nature Protocols, 2(5), 1084\u20131104. https:\/\/doi.org\/10.1038\/nprot.2007.77.","journal-title":"Nature Protocols"},{"issue":"5192","key":"1275_CR21","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1126\/science.7997877","volume":"266","author":"LH Hartwell","year":"1994","unstructured":"Hartwell, L. H., & Kastan, M. B. (1994). Cell cycle control and cancer. Science (New York, N.Y.), 266(5192), 1821\u20131828. https:\/\/doi.org\/10.1126\/science.7997877.","journal-title":"Science (New York, N.Y.)"},{"issue":"3","key":"1275_CR22","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/85798","volume":"27","author":"KK Khanna","year":"2001","unstructured":"Khanna, K. K., & Jackson, S. P. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27(3), 247\u2013254. https:\/\/doi.org\/10.1038\/85798.","journal-title":"Nature Genetics"},{"issue":"1","key":"1275_CR23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0959-437X(00)00159-3","volume":"11","author":"Y Shiloh","year":"2001","unstructured":"Shiloh, Y. (2001). ATM and ATR: networking cellular responses to DNA damage. Current Opinion in Genetics & Development, 11(1), 71\u201377. https:\/\/doi.org\/10.1016\/S0959-437X(00)00159-3.","journal-title":"Current Opinion in Genetics & Development"},{"issue":"5","key":"1275_CR24","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/00008571-199510000-00001","volume":"5","author":"DL Eaton","year":"1995","unstructured":"Eaton, D. L., Gallagher, E. P., Bammler, T. K., & Kunze, K. L. (1995). Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. Pharmacogenetics, 5(5), 259\u2013274. https:\/\/doi.org\/10.1097\/00008571-199510000-00001.","journal-title":"Pharmacogenetics"},{"issue":"2","key":"1275_CR25","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1158\/1055-9965.EPI-04-0295","volume":"14","author":"AJ Lee","year":"2005","unstructured":"Lee, A. J., Hodges, N. J., & Chipman, J. K. (2005). Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2\u2019-deoxyguanosine DNA glycosylase 1. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 14(2), 497\u2013505. https:\/\/doi.org\/10.1158\/1055-9965.EPI-04-0295.","journal-title":"Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology"},{"issue":"4","key":"1275_CR26","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1093\/nar\/26.4.1032","volume":"26","author":"M Shen","year":"1998","unstructured":"Shen, M. (1998). Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair. Nucleic Acids Research, 26(4), 1032\u20131037. https:\/\/doi.org\/10.1093\/nar\/26.4.1032.","journal-title":"Nucleic Acids Research"},{"issue":"5247","key":"1275_CR27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.271.5247.353","volume":"271","author":"NC Walworth","year":"1996","unstructured":"Walworth, N. C., & Bernards, R. (1996). rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science (New York, N.Y.), 271(5247), 353\u2013356. https:\/\/doi.org\/10.1126\/science.271.5247.353.","journal-title":"Science (New York, N.Y.)"},{"issue":"6811","key":"1275_CR28","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/35044005","volume":"408","author":"B-BS Zhou","year":"2000","unstructured":"Zhou, B.-B. S., & Elledge, S. J. (2000). The DNA damage response: putting checkpoints in perspective. Nature, 408(6811), 433\u2013439. https:\/\/doi.org\/10.1038\/35044005.","journal-title":"Nature"},{"issue":"1","key":"1275_CR29","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1269\/jrr.0642","volume":"48","author":"M Kan\u2019o","year":"2007","unstructured":"Kan\u2019o, M., Kawata, T., Ito, H., Shigematsu, N., Liu, C., Uno, T., & Kubo, A. (2007). Repair of potentially lethal damage in normal cells and ataxia telangiectasia cells; consideration of non-homologous end-joining. Journal of Radiation Research, 48(1), 31\u201338. https:\/\/doi.org\/10.1269\/jrr.0642.","journal-title":"Journal of Radiation Research"},{"issue":"3","key":"1275_CR30","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1093\/nar\/7.3.793","volume":"7","author":"MO Bradley","year":"1979","unstructured":"Bradley, M. O., & Kohn, K. W. (1979). X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution. Nucleic Acids Research, 7(3), 793\u2013804. https:\/\/doi.org\/10.1093\/nar\/7.3.793.","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"1275_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1080\/09553008214551241","volume":"42","author":"D Bl\u00f6cher","year":"1982","unstructured":"Bl\u00f6cher, D., & Pohlit, W. (1982). DNA double-strand breaks in Ehrlich ascites tumour cells at low doses of x-rays. II. Can cell death be attributed to double strand breaks? International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine, 42(3), 329\u2013338. https:\/\/doi.org\/10.1080\/09553008214551241.","journal-title":"International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine"},{"issue":"7","key":"1275_CR32","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.7150\/ijbs.41246","volume":"16","author":"L Bian","year":"2020","unstructured":"Bian, L., Meng, Y., Zhang, M., Guo, Z., Liu, F., Zhang, W., & Li, D. (2020). ATM Expression Is Elevated in Established Radiation-Resistant Breast Cancer Cells and Improves DNA Repair Efficiency. International Journal of Biological Sciences, 16(7), 1096\u20131106. https:\/\/doi.org\/10.7150\/ijbs.41246.","journal-title":"International Journal of Biological Sciences"},{"issue":"10","key":"1275_CR33","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1080\/095530099139359","volume":"75","author":"MF Lavin","year":"1999","unstructured":"Lavin, M. F., & Khanna, K. K. (1999). ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia. International Journal of Radiation Biology, 75(10), 1201\u20131214. https:\/\/doi.org\/10.1080\/095530099139359.","journal-title":"International Journal of Radiation Biology"},{"issue":"6423","key":"1275_CR34","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/362849a0","volume":"362","author":"AR Clarke","year":"1993","unstructured":"Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993). Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature, 362(6423), 849\u2013852. https:\/\/doi.org\/10.1038\/362849a0.","journal-title":"Nature"},{"issue":"1","key":"1275_CR35","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/sj.onc.1210634","volume":"27","author":"P Venkatachalam","year":"2008","unstructured":"Venkatachalam, P., De Toledo, S. M., Pandey, B. N., Tephly, L. A., Carter, A. B., Little, J. B., & Azzam, E. I. (2008). Regulation of normal cell cycle progression by flavin-containing oxidases. Oncogene, 27(1), 20\u201331. https:\/\/doi.org\/10.1038\/sj.onc.1210634.","journal-title":"Oncogene"},{"issue":"3","key":"1275_CR36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/cyto.a.20357","volume":"71","author":"M Kajstura","year":"2007","unstructured":"Kajstura, M., Halicka, H. D., Pryjma, J., & Darzynkiewicz, Z. (2007). Discontinuous fragmentation of nuclear DNA during apoptosis revealed by discrete \u201csub-G1\u201d peaks on DNA content histograms. Cytometry. Part A: The Journal of the International Society for Analytical Cytology, 71(3), 125\u2013131. https:\/\/doi.org\/10.1002\/cyto.a.20357.","journal-title":"Cytometry. Part A: The Journal of the International Society for Analytical Cytology"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-024-01275-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-024-01275-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-024-01275-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T06:20:04Z","timestamp":1724480404000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-024-01275-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1275"],"URL":"https:\/\/doi.org\/10.1007\/s12013-024-01275-z","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"type":"print","value":"1085-9195"},{"type":"electronic","value":"1559-0283"}],"subject":[],"published":{"date-parts":[[2024,5,2]]},"assertion":[{"value":"8 April 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}