{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:16:24Z","timestamp":1785240984640,"version":"3.55.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s12013-024-01376-9","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T06:02:25Z","timestamp":1721196145000},"page":"2651-2671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biological Applications, In Vitro Cytotoxicity, Cellular Uptake, and Apoptotic Pathway Studies Induced by Ternary Cu (II) Complexes Involving Triflupromazine with Biorelevant Ligands"],"prefix":"10.1007","volume":"82","author":[{"given":"Nourhan S.","family":"Sultan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza A.","family":"Shoukry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma B.","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba K. A.","family":"Elhakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"issue":"45","key":"1376_CR1","doi-asserted-by":"publisher","first-page":"17263","DOI":"10.1039\/D2DT02237K","volume":"51","author":"P Selvam","year":"2022","unstructured":"Selvam, P., De, S., Paira, P., Kumar, S. K. A., Kumar R, S., Moorthy, A., Ghosh, A., Kuo, Y.-C., Banerjee, S., & Jenifer, S. K. (2022). In vitro studies on the selective cytotoxic effect of luminescent Ru(ii)-p-cymene complexes of imidazo-pyridine and imidazo quinoline ligands. Dalton Transactions, 51(45), 17263\u201317276.","journal-title":"Dalton Transactions"},{"key":"1376_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jinorgbio.2016.02.033","volume":"159","author":"L Jia","year":"2016","unstructured":"Jia, L., Xu, J., Zhao, X., Shen, S., Zhou, T., Xu, Z., Zhu, T., Chen, R., Ma, T., Xie, J., Dong, K., & Huang, J. (2016). Synthesis, characterization, and antitumor activity of three ternary dinuclear copper (II) complexes with a reduced Schiff base ligand and diimine coligands in vitro and in vivo. Journal of Inorganic Biochemistry, 159, 107\u2013119.","journal-title":"Journal of Inorganic Biochemistry"},{"key":"1376_CR3","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.3390\/molecules20022115","volume":"20","author":"L Kuckov\u00e1","year":"2015","unstructured":"Kuckov\u00e1, L., Jomov\u00e1, K., \u0160vorcov\u00e1, A., Valko, M., Seg\u013ea, P., Monco\u013e, J., & Ko\u017e\u00ed\u0161ek, J. (2015). Synthesis, crystal structure, spectroscopic properties and potential biological activities of salicylate\u2012neocuproine ternary copper(II) complexes. Molecules, 20, 2115\u20132137. https:\/\/doi.org\/10.3390\/molecules20022115.","journal-title":"Molecules"},{"key":"1376_CR4","doi-asserted-by":"publisher","first-page":"119641","DOI":"10.1016\/j.ica.2020.119641","volume":"508","author":"S De","year":"2020","unstructured":"De, S., & Ashok Kumar, S. K. (2020). Development of highly potent Arene-Ru (II)-ninhydrin complexes for inhibition of cancer cell growth. Inorganica Chimica Acta, 508, 119641.","journal-title":"Inorganica Chimica Acta"},{"issue":"8","key":"1376_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrc2167","volume":"7","author":"L Kelland","year":"2007","unstructured":"Kelland, L. (2007). The resurgence of platinum-based cancer chemotherapy. Nature Reviews Cancer, 7(8), 573\u2013584.","journal-title":"Nature Reviews Cancer"},{"key":"1376_CR6","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jinorgbio.2014.06.007","volume":"139","author":"S Iglesias","year":"2014","unstructured":"Iglesias, S., Alvarez, N., Torre, M. H., Kremer, E., Ellena, J., Ribeiro, R. R., Barroso, R. P., Costa-Filho, A. J., Kramer, M. G., & Facchin, G. (2014). Synthesis, structural characterization and cytotoxic activity of ternary copper(II)\u2013dipeptide\u2013phenanthroline complexes. A step towards the development of new copper compounds for the treatment of cancer. Journal of Inorganic Biochemistry, 139, 117\u2013123.","journal-title":"Journal of Inorganic Biochemistry"},{"issue":"12","key":"1376_CR7","doi-asserted-by":"publisher","first-page":"4555","DOI":"10.1080\/07391102.2020.1776641","volume":"39","author":"BS Bhatt","year":"2021","unstructured":"Bhatt, B. S., Gandhi, D. H., Vaidya, F. U., Pathak, C., & Patel, T. N. (2021). Cell apoptosis induced by ciprofloxacin based Cu(II) complexes: cytotoxicity, SOD mimic and antibacterial studies. Journal of Biomolecular Structure and Dynamics, 39(12), 4555\u20134562.","journal-title":"Journal of Biomolecular Structure and Dynamics"},{"issue":"2","key":"1376_CR8","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s11030-021-10199-2","volume":"26","author":"DH Gandhi","year":"2022","unstructured":"Gandhi, D. H., Vaidya, F. U., Pathak, C., Patel, T. N., & Bhatt, B. S. (2022). Mechanistic insight of cell anti-proliferative activity of fluoroquinolone drug-based Cu(II) complexes. Molecular Diversity, 26(2), 869\u2013878.","journal-title":"Molecular Diversity"},{"key":"1376_CR9","doi-asserted-by":"publisher","first-page":"109231","DOI":"10.1016\/j.cbi.2020.109231","volume":"330","author":"RR Varma","year":"2020","unstructured":"Varma, R. R., Pandya, J. G., Vaidya, F. U., Pathak, C., Bhatt, B. S., & Patel, M. N. (2020). Biological activities of pyrazoline-indole based Re(I) carbonyls: DNA interaction, antibacterial, anticancer, ROS production, lipid peroxidation, in vivo and in vitro cytotoxicity studies. Chemico-Biological Interactions, 330, 109231.","journal-title":"Chemico-Biological Interactions"},{"key":"1376_CR10","first-page":"8","volume":"3","author":"MN Arumugham","year":"2013","unstructured":"Arumugham, M. N. (2013). Synthesis, characterisation, DNA-binding studies and antimicrobial activity of copper(II) complex with 1,10 phenanthroline, L-tyrosine and urea as ligands. International Journal of Inorganic and Bioinorganic Chemistry, 3, 8\u201315.","journal-title":"International Journal of Inorganic and Bioinorganic Chemistry"},{"issue":"12","key":"1376_CR11","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1002\/cbdv.201100372","volume":"9","author":"MN Patel","year":"2012","unstructured":"Patel, M. N., Bhatt, B. S., & Dosi, P. A. (2012). Study of SOD mimic and nucleic acid interaction activity exerted by enrofloxacin-based copper(II) complexes. Chemistry & Biodiversity, 9(12), 2810\u20132824.","journal-title":"Chemistry & Biodiversity"},{"key":"1376_CR12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.inoche.2014.10.014","volume":"50","author":"X Li","year":"2014","unstructured":"Li, X., Bi, C.-F., Fan, Y.-H., Zhang, X., Meng, X.-M., & Cui, L.-S. (2014). Synthesis, crystal structure and anticancer activity of a novel ternary copper(II) complex with Schiff base derived from 2-amino-4-fluorobenzoic acid and salicylaldehyde. Inorganic Chemistry Communications, 50, 35\u201341.","journal-title":"Inorganic Chemistry Communications"},{"issue":"5","key":"1376_CR13","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.3892\/mmr.2014.2519","volume":"10","author":"T Zhu","year":"2014","unstructured":"Zhu, T., Chen, R., Yu, H., Feng, Y., Chen, J., Lu, Q., Xie, J., Ding, W., & Ma, T. (2014). Antitumor effect of a copper (II) complex of a coumarin derivative and phenanthroline on lung adenocarcinoma cells and the mechanism of action. Molecular Medicine Reports, 10(5), 2477\u20132482.","journal-title":"Molecular Medicine Reports"},{"issue":"7","key":"1376_CR14","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1021\/acs.cgd.6b01860","volume":"17","author":"L Chen","year":"2017","unstructured":"Chen, L., Dong, W.-K., Zhang, H., Zhang, Y., & Sun, Y.-X. (2017). Structural variation and luminescence properties of tri- and dinuclear CuII and ZnII complexes constructed from a naphthalenediol-based bis(salamo)-type ligand. Crystal Growth & Design, 17(7), 3636\u20133648.","journal-title":"Crystal Growth & Design"},{"key":"1376_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.molstruc.2014.10.014","volume":"1082","author":"WH Mahmoud","year":"2015","unstructured":"Mahmoud, W. H., Mohamed, G. G., & El-Dessouky, M. M. I. (2015). Synthesis, structural characterization, in vitro antimicrobial and anticancer activity studies of ternary metal complexes containing glycine amino acid and the anti-inflammatory drug lornoxicam. Journal of Molecular Structure, 1082, 12\u201322.","journal-title":"Journal of Molecular Structure"},{"issue":"2","key":"1376_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.bbrc.2003.12.089","volume":"314","author":"N Grosser","year":"2004","unstructured":"Grosser, N., Oberle, S., Berndt, G., Erdmann, K., Hemmerle, A., & Schr\u00f6der, H. (2004). Antioxidant action of l-alanine: heme oxygenase-1 and ferritin as possible mediators. Biochemical and Biophysical Research Communications, 314(2), 351\u2013355.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"11","key":"1376_CR17","first-page":"5983","volume":"37","author":"V Borisz","year":"2017","unstructured":"Borisz, V., \u00c1Kos, C., Andrea, C., Joseph, M., Leonard, A., & Gabriella, S. (2017). Possible biological and clinical applications of phenothiazines. Anticancer Research, 37(11), 5983 p.","journal-title":"Anticancer Research"},{"key":"1376_CR18","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.biopha.2018.06.170","volume":"106","author":"K \u015aroda-Pomianek","year":"2018","unstructured":"\u015aroda-Pomianek, K., Michalak, K., \u015awi\u0105tek, P., Po\u0142a, A., Palko-\u0141abuz, A., & Weso\u0142owska, O. (2018). Increased lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line LoVo and its doxorubicin-resistant subline LoVo\/Dx in the presence of newly synthesized phenothiazine derivatives. Biomedicine & Pharmacotherapy, 106, 624\u2013636.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1376_CR19","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.molstruc.2015.06.055","volume":"1099","author":"V Kumar","year":"2015","unstructured":"Kumar, V., Upadhyay, N., & Manhas, A. (2015). Designing, syntheses, characterization, computational study and biological activities of silver-phenothiazine metal complex. Journal of Molecular Structure, 1099, 135\u2013141.","journal-title":"Journal of Molecular Structure"},{"issue":"20","key":"1376_CR20","doi-asserted-by":"publisher","first-page":"5840","DOI":"10.1016\/j.electacta.2010.05.033","volume":"55","author":"MV Colqui Quiroga","year":"2010","unstructured":"Colqui Quiroga, M. V., Monz\u00f3n, L. M. A., & Yudi, L. M. (2010). Interaction of triflupromazine with distearoylphosphatidylglycerol films studied by surface pressure isotherms and cyclic voltammetry at a 1,2-dichloroethane\/water interface. Electrochimica Acta, 55(20), 5840\u20135846.","journal-title":"Electrochimica Acta"},{"issue":"2","key":"1376_CR21","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.schres.2011.02.018","volume":"129","author":"FH-C Chou","year":"2011","unstructured":"Chou, F. H.-C., Tsai, K.-Y., Su, C.-Y., & Lee, C.-C. (2011). The incidence and relative risk factors for developing cancer among patients with schizophrenia: A nine-year follow-up study. Schizophrenia Research, 129(2), 97\u2013103.","journal-title":"Schizophrenia Research"},{"issue":"4","key":"1376_CR22","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrn3464","volume":"14","author":"R Tabar\u00e9s-Seisdedos","year":"2013","unstructured":"Tabar\u00e9s-Seisdedos, R., & Rubenstein, J. L. (2013). Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nature Reviews Neuroscience, 14(4), 293\u2013304.","journal-title":"Nature Reviews Neuroscience"},{"issue":"1","key":"1376_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/S1734-1140(12)70726-0","volume":"64","author":"A Jaszczyszyn","year":"2012","unstructured":"Jaszczyszyn, A., G\u0105siorowski, K., \u015awi\u0105tek, P., Malinka, W., Cie\u015blik-Boczula, K., Petrus, J., & Czarnik-Matusewicz, B. (2012). Chemical structure of phenothiazines and their biological activity. Pharmacological Reports, 64(1), 16\u201323.","journal-title":"Pharmacological Reports"},{"issue":"n\/a","key":"1376_CR24","doi-asserted-by":"publisher","first-page":"e202300450","DOI":"10.1002\/cbdv.202300450","volume":"n\/a","author":"NS Sultan","year":"2023","unstructured":"Sultan, N. S., Elhakim, H. K. A., Shoukry, A. A., & Rashidi, F. B. (2023). Synthesis, characterization, and biological evaluation of Cu(II) complexes containing triflupromazine with glycine and histidine. Chemistry & Biodiversity, n\/a(n\/a), e202300450.","journal-title":"Chemistry & Biodiversity"},{"issue":"1","key":"1376_CR25","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-266","volume":"13","author":"M Donalisio","year":"2013","unstructured":"Donalisio, M., Nana, H. M., Ngono Ngane, R. A., Gatsing, D., Tiabou Tchinda, A., Rovito, R., Cagno, V., Cagliero, C., Boyom, F. F., Rubiolo, P., Bicchi, C., & Lembo, D. (2013). In vitro anti-Herpes simplex virus activity of crude extract of the roots of Nauclea latifolia Smith (Rubiaceae). BMC Complementary and Alternative Medicine, 13(1), 266.","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"3","key":"1376_CR26","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/nprot.2006.179","volume":"1","author":"V Vichai","year":"2006","unstructured":"Vichai, V., & Kirtikara, K. (2006). Sulforhodamine B colorimetric assay for cytotoxicity screening. Nature Protocols, 1(3), 1112\u20131116.","journal-title":"Nature Protocols"},{"issue":"4","key":"1376_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/0166-0934(88)90134-6","volume":"20","author":"R Pauwels","year":"1988","unstructured":"Pauwels, R., Balzarini, J., Baba, M., Snoeck, R., Schols, D., Herdewijn, P., Desmyter, J., & De Clercq, E. (1988). Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. Journal of Virological Methods, 20(4), 309\u2013321.","journal-title":"Journal of Virological Methods"},{"key":"1376_CR28","doi-asserted-by":"crossref","unstructured":"Zandi, K., Zadeh, M. A., Sartavi, K. & Rastian, Z. (2007). Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. African Journal of Biotechnology. 6 (15).","DOI":"10.5897\/AJB2007.000-2276"},{"key":"1376_CR29","first-page":"2164","volume":"10","author":"R Al-salahi","year":"2013","unstructured":"Al-salahi, R., Al-Swaidan, I., Al-Omar, M., & Marzouk, M. (2013). Antiviral activity of 2-phenoxy-[1,2,4]triazolo[1,5-\u03b1]quinazoline derivatives. Life Science Journal, 10, 2164\u20132169.","journal-title":"Life Science Journal"},{"issue":"3","key":"1376_CR30","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.exppara.2012.11.025","volume":"133","author":"NS Vila-Nova","year":"2013","unstructured":"Vila-Nova, N. S., de Morais, S. M., Falc\u00e3o, M. J. C., Alcantara, T. T. N., Ferreira, P. A. T., Cavalcanti, E. S. B., Vieira, I. G. P., Campello, C. C., & Wilson, M. (2013). Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone. Experimental Parasitology, 133(3), 334\u2013338. p.","journal-title":"Experimental Parasitology"},{"issue":"1","key":"1376_CR31","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.actatropica.2011.12.008","volume":"122","author":"L Tritten","year":"2012","unstructured":"Tritten, L., Nwosu, U., Vargas, M., & Keiser, J. (2012). In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum. Acta Tropica, 122(1), 101\u2013107.","journal-title":"Acta Tropica"},{"issue":"2","key":"1376_CR32","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.parint.2016.11.012","volume":"66","author":"DM Abou Rayia","year":"2017","unstructured":"Abou Rayia, D. M., Saad, A. E., Ashour, D. S., & Oreiby, R. M. (2017). Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies. Parasitology International, 66(2), 56\u201363.","journal-title":"Parasitology International"},{"issue":"1","key":"1376_CR33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S1658-3655(12)60018-1","volume":"3","author":"FA Bughdadi","year":"2010","unstructured":"Bughdadi, F. A. (2010). Ultrastractural studies on the parasitic worm Trichinella Spiralis. Journal of Taibah University for Science, 3(1), 33\u201338.","journal-title":"Journal of Taibah University for Science"},{"issue":"1","key":"1376_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/2008-2231-20-76","volume":"20","author":"CA Anosike","year":"2012","unstructured":"Anosike, C. A., Obidoa, O., & Ezeanyika, L. U. S. (2012). Membrane stabilization as a mechanism of the anti-inflammatory activity of methanol extract of garden egg (Solanum aethiopicum). DARU Journal of Pharmaceutical Sciences, 20(1), 76.","journal-title":"DARU Journal of Pharmaceutical Sciences"},{"issue":"21","key":"1376_CR35","doi-asserted-by":"publisher","first-page":"e1984","DOI":"10.21769\/BioProtoc.1984","volume":"6","author":"EA Orellana","year":"2016","unstructured":"Orellana, E. A., & Kasinski, A. L. (2016). Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation. Bio-protocol, 6(21), e1984\u2013e1984.","journal-title":"Bio-protocol"},{"key":"1376_CR36","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jinorgbio.2017.07.002","volume":"175","author":"W Hu","year":"2017","unstructured":"Hu, W., Fang, L., Hua, W., & Gou, S. (2017). Biotin-Pt (IV)-indomethacin hybrid: A targeting anticancer prodrug providing enhanced cancer cellular uptake and reversing cisplatin resistance. Journal of Inorganic Biochemistry, 175, 47\u201357.","journal-title":"Journal of Inorganic Biochemistry"},{"issue":"1","key":"1376_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-018-1427-5","volume":"16","author":"MRKL Lie","year":"2018","unstructured":"Lie, M. R. K. L., van der Giessen, J., Fuhler, G. M., de Lima, A., Peppelenbosch, M. P., van der Ent, C., & van der Woude, C. J. (2018). Low dose Naltrexone for induction of remission in inflammatory bowel disease patients. Journal of Translational Medicine, 16(1), 55.","journal-title":"Journal of Translational Medicine"},{"issue":"1","key":"1376_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36089-6","volume":"9","author":"MI Fekry","year":"2019","unstructured":"Fekry, M. I., Ezzat, S. M., Salama, M. M., Alshehri, O. Y., & Al-Abd, A. M. (2019). Bioactive glycoalkaloides isolated from Solanum melongena fruit peels with potential anticancer properties against hepatocellular carcinoma cells. Scientific Reports, 9(1), 1746.","journal-title":"Scientific Reports"},{"issue":"1","key":"1376_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-30046-z","volume":"8","author":"HA Bashmail","year":"2018","unstructured":"Bashmail, H. A., Alamoudi, A. A., Noorwali, A., Hegazy, G. A., AJabnoor, G., Choudhry, H., & Al-Abd, A. M. (2018). Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities. Scientific Reports, 8(1), 1\u201311.","journal-title":"Scientific Reports"},{"issue":"8","key":"1376_CR40","doi-asserted-by":"publisher","first-page":"12280","DOI":"10.1002\/jcb.28491","volume":"120","author":"A Rezaei","year":"2019","unstructured":"Rezaei, A., Mahmoodi, M., Mohammadizadeh, F., Mohamadi, M., Hajizadeh, M. R., Mirzaei, M. R., & Khanamani Falahati-Pour, S. (2019). A novel copper (II) complex activated both extrinsic and intrinsic apoptotic pathways in liver cancerous cells. Journal of Cellular Biochemistry, 120(8), 12280\u201312289.","journal-title":"Journal of Cellular Biochemistry"},{"issue":"21","key":"1376_CR41","doi-asserted-by":"publisher","first-page":"12996","DOI":"10.1039\/C7NJ01998J","volume":"41","author":"N Biswas","year":"2017","unstructured":"Biswas, N., Khanra, S., Sarkar, A., Bhattacharjee, S., Prasad Mandal, D., Chaudhuri, A., Chakraborty, S., & Roy Choudhury, C. (2017). One new azido bridged dinuclear copper(ii) thiosemicarbazide complex: synthesis, DNA\/protein binding, molecular docking study and cytotoxicity activity. New Journal of Chemistry, 41(21), 12996\u201313011.","journal-title":"New Journal of Chemistry"},{"issue":"16","key":"1376_CR42","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. Journal of Computational Chemistry, 30(16), 2785\u20132791.","journal-title":"Journal of Computational Chemistry"},{"key":"1376_CR43","doi-asserted-by":"publisher","first-page":"126901","DOI":"10.1016\/j.molstruc.2019.126901","volume":"1199","author":"A De","year":"2020","unstructured":"De, A., Ray, H. P., Jain, P., Kaur, H., & Singh, N. (2020). Synthesis, characterization, molecular docking and DNA cleavage study of transition metal complexes of o-vanillin and glycine-derived Schiff base ligand. Journal of Molecular Structure, 1199, 126901.","journal-title":"Journal of Molecular Structure"},{"issue":"3","key":"1376_CR44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.2116\/analsci.22.439","volume":"22","author":"M Aslanoglu","year":"2006","unstructured":"Aslanoglu, M. (2006). Electrochemical and spectroscopic studies of the interaction of proflavine with DNA. Analytical Sciences, 22(3), 439\u2013443.","journal-title":"Analytical Sciences"},{"issue":"3","key":"1376_CR45","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.bpc.2005.04.009","volume":"116","author":"N Li","year":"2005","unstructured":"Li, N., Ma, Y., Yang, C., Guo, L., & Yang, X. (2005). Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods. Biophysical Chemistry, 116(3), 199\u2013205.","journal-title":"Biophysical Chemistry"},{"issue":"3","key":"1376_CR46","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.saa.2009.12.061","volume":"75","author":"A Shah","year":"2010","unstructured":"Shah, A., Zaheer, M., Qureshi, R., Akhter, Z., & Faizan Nazar, M. (2010). Voltammetric and spectroscopic investigations of 4-nitrophenylferrocene interacting with DNA. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 75(3), 1082\u20131087.","journal-title":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"},{"key":"1376_CR47","doi-asserted-by":"publisher","first-page":"173553","DOI":"10.1016\/j.ejphar.2020.173553","volume":"887","author":"M Otr\u0119ba","year":"2020","unstructured":"Otr\u0119ba, M., Ko\u015bmider, L., & Rzepecka-Stojko, A. (2020). Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review. European Journal of Pharmacology, 887, 173553.","journal-title":"European Journal of Pharmacology"},{"issue":"Pt 3","key":"1376_CR48","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1099\/vir.0.061911-0","volume":"95","author":"BJ Hart","year":"2014","unstructured":"Hart, B. J., Dyall, J., Postnikova, E., Zhou, H., Kindrachuk, J., Johnson, R. F., Olinger, Jr, G. G., Frieman, M. B., Holbrook, M. R., & Jahrling, P. B. (2014). Interferon-\u03b2 and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays. The Journal of General Virology, 95(Pt 3), 571.","journal-title":"The Journal of General Virology"},{"issue":"1","key":"1376_CR49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.7150\/thno.21425","volume":"8","author":"Z Zeng","year":"2018","unstructured":"Zeng, Z., Zhang, R., Hong, W., Cheng, Y., Wang, H., Lang, Y., Ji, Z., Wu, Y., Li, W., & Xie, Y. (2018). Histidine-rich modification of a scorpion-derived peptide improves bioavailability and inhibitory activity against HSV-1. Theranostics, 8(1), 199.","journal-title":"Theranostics"},{"issue":"1","key":"1376_CR50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00436-010-1827-9","volume":"107","author":"MA Shalaby","year":"2010","unstructured":"Shalaby, M. A., Moghazy, F. M., Shalaby, H. A., & Nasr, S. M. (2010). Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats. Parasitology Research, 107(1), 17\u201325.","journal-title":"Parasitology Research"},{"issue":"1","key":"1376_CR51","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00436-011-2551-9","volume":"110","author":"AK Yadav","year":"2012","unstructured":"Yadav, A. K., & Temjenmongla (2012). Efficacy of Lasia spinosa leaf extract in treating mice infected with Trichinella spiralis. Parasitology Research, 110(1), 493\u2013498.","journal-title":"Parasitology Research"},{"issue":"7","key":"1376_CR52","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/1469-0691.12162","volume":"19","author":"O Djurkovi\u0107-Djakovi\u0107","year":"2013","unstructured":"Djurkovi\u0107-Djakovi\u0107, O., Bobi\u0107, B., Nikoli\u0107, A., Klun, I., & Dupouy-Camet, J. (2013). Pork as a source of human parasitic infection. Clinical Microbiology and Infection, 19(7), 586\u2013594.","journal-title":"Clinical Microbiology and Infection"},{"key":"1376_CR53","doi-asserted-by":"publisher","first-page":"661","DOI":"10.3389\/fphar.2018.00661","volume":"9","author":"SM Abdul Wahab","year":"2018","unstructured":"Abdul Wahab, S. M., Jantan, I., Haque, M. A., & Arshad, L. (2018). Exploring the leaves of Annona muricata L. as a source of potential anti-inflammatory and anticancer agents. Frontiers in Pharmacology, 9, 661.","journal-title":"Frontiers in Pharmacology"},{"issue":"4","key":"1376_CR54","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/0169-4758(90)90227-U","volume":"6","author":"E Lacey","year":"1990","unstructured":"Lacey, E. (1990). Mode of action of benzimidazoles. Parasitology Today, 6(4), 112\u2013115.","journal-title":"Parasitology Today"},{"key":"1376_CR55","doi-asserted-by":"publisher","unstructured":"Gunathilake, K. D. P. P., Ranaweera, K. K. D. S. & Rupasinghe, H. P. V. (2018). In vitro anti-inflammatory properties of selected green leafy vegetables. Biomedicines. 6, https:\/\/doi.org\/10.3390\/biomedicines6040107.","DOI":"10.3390\/biomedicines6040107"},{"issue":"5","key":"1376_CR56","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4236\/abc.2021.115013","volume":"11","author":"TO Aiyelabola","year":"2021","unstructured":"Aiyelabola, T. O. (2021). Syntheses, characterization and biological activity of novel thiazoylazo dye and its coordination compounds. Advances in Biological Chemistry, 11(5), 179\u2013205.","journal-title":"Advances in Biological Chemistry"},{"issue":"4","key":"1376_CR57","doi-asserted-by":"publisher","first-page":"e3582","DOI":"10.1002\/aoc.3582","volume":"31","author":"M Mohanraj","year":"2017","unstructured":"Mohanraj, M., Ayyannan, G., Raja, G., & Jayabalakrishnan, C. (2017). Synthesis, characterization and in vitro biological assays of copper(II) and nickel(II) complexes with furan-\u00ad2\u00ad-carboxylic acid hydrazide. Applied Organometallic Chemistry, 31(4), e3582.","journal-title":"Applied Organometallic Chemistry"},{"issue":"2","key":"1376_CR58","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S1534-5807(02)00120-X","volume":"2","author":"CM Franz","year":"2002","unstructured":"Franz, C. M., Jones, G. E., & Ridley, A. J. (2002). Cell migration in development and disease. Developmental Cell, 2(2), 153\u2013158.","journal-title":"Developmental Cell"},{"issue":"13","key":"1376_CR59","doi-asserted-by":"publisher","first-page":"5226","DOI":"10.1021\/acs.jmedchem.5b00651","volume":"58","author":"P Nagababu","year":"2015","unstructured":"Nagababu, P., Barui, A. K., Thulasiram, B., Devi, C. S., Satyanarayana, S., Patra, C. R., & Sreedhar, B. (2015). Antiangiogenic activity of mononuclear copper(II) polypyridyl complexes for the treatment of cancers. Journal of Medicinal Chemistry, 58(13), 5226\u20135241.","journal-title":"Journal of Medicinal Chemistry"},{"issue":"5","key":"1376_CR60","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nrc.2018.15","volume":"18","author":"CH Stuelten","year":"2018","unstructured":"Stuelten, C. H., Parent, C. A., & Montell, D. J. (2018). Cell motility in cancer invasion and metastasis: insights from simple model organisms. Nature Reviews Cancer, 18(5), 296\u2013312.","journal-title":"Nature Reviews Cancer"},{"issue":"9","key":"1376_CR61","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1039\/C7MD00067G","volume":"8","author":"I Ali","year":"2017","unstructured":"Ali, I., Lone, M. N., & Aboul-Enein, H. Y. (2017). Imidazoles as potential anticancer agents. MedChemComm, 8(9), 1742\u20131773.","journal-title":"MedChemComm"},{"issue":"8","key":"1376_CR62","doi-asserted-by":"publisher","first-page":"101284","DOI":"10.1016\/j.jscs.2021.101284","volume":"25","author":"S Nayak","year":"2021","unstructured":"Nayak, S., Gaonkar, S. L., Musad, E. A., & Dawsar, A. M. A. L. (2021). 1,3,4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships. Journal of Saudi Chemical Society, 25(8), 101284.","journal-title":"Journal of Saudi Chemical Society"},{"issue":"6","key":"1376_CR63","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1081\/SL-120016277","volume":"35","author":"X Wang","year":"2002","unstructured":"Wang, X., Li, Y., Gong, S., & Fu, D. (2002). A spectroscopic study on the dna binding behavior of the anticancer drug dacarbazine. Spectroscopy Letters, 35(6), 751\u2013756.","journal-title":"Spectroscopy Letters"},{"issue":"7","key":"1376_CR64","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s00775-008-0400-9","volume":"13","author":"S Chatterjee","year":"2008","unstructured":"Chatterjee, S., Kundu, S., Bhattacharyya, A., Hartinger, C. G., & Dyson, P. J. (2008). The ruthenium(II)\u2013arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53\u2013JNK pathways. Journal of Biological Inorganic Chemistry, 13(7), 1149\u20131155.","journal-title":"Journal of Biological Inorganic Chemistry"},{"issue":"2","key":"1376_CR65","doi-asserted-by":"publisher","first-page":"e6082","DOI":"10.1002\/aoc.6082","volume":"35","author":"ME El-Afify","year":"2021","unstructured":"El-Afify, M. E., Elsayed, S. A., Shalaby, T. I., Toson, E. A., & El-Hendawy, A. M. (2021). Synthesis, characterization, DNA binding\/cleavage, cytotoxic, apoptotic, and antibacterial activities of V(IV), Mo(VI), and Ru(II) complexes containing a bioactive ONS-donor chelating agent. Applied Organometallic Chemistry, 35(2), e6082 p.","journal-title":"Applied Organometallic Chemistry"},{"issue":"17","key":"1376_CR66","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1007\/s00018-008-8329-2","volume":"65","author":"T Chen","year":"2008","unstructured":"Chen, T., & Wong, Y. S. (2008). Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation. Cellular and Molecular Life Sciences, 65(17), 2763.","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"11","key":"1376_CR67","doi-asserted-by":"publisher","first-page":"E255","DOI":"10.1038\/ncb1101-e255","volume":"3","author":"KF Ferri","year":"2001","unstructured":"Ferri, K. F., & Kroemer, G. (2001). Organelle-specific initiation of cell death pathways. Nature Cell Biology, 3(11), E255\u2013E263.","journal-title":"Nature Cell Biology"},{"issue":"7","key":"1376_CR68","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S1471-4914(01)02026-3","volume":"7","author":"JC Reed","year":"2001","unstructured":"Reed, J. C. (2001). Apoptosis-regulating proteins as targets for drug discovery. Trends in Molecular Medicine, 7(7), 314\u2013319.","journal-title":"Trends in Molecular Medicine"},{"issue":"6907","key":"1376_CR69","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/nature01101","volume":"419","author":"VS Marsden","year":"2002","unstructured":"Marsden, V. S., O\u2019Connor, L., O\u2019Reilly, L. A., Silke, J., Metcalf, D., Ekert, P. G., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., Roy, S., Nicholson, D. W., Vaux, D. L., Bouillet, P., Adams, J. M., & Strasser, A. (2002). Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c\/Apaf-1\/caspase-9 apoptosome. Nature, 419(6907), 634\u2013637.","journal-title":"Nature"},{"issue":"8","key":"1376_CR70","doi-asserted-by":"publisher","first-page":"e69534","DOI":"10.1371\/journal.pone.0069534","volume":"8","author":"MA Siddiqui","year":"2013","unstructured":"Siddiqui, M. A., Alhadlaq, H. A., Ahmad, J., Al-Khedhairy, A. A., Musarrat, J., & Ahamed, M. (2013). Copper oxide nanoparticles induced mitochondria-mediated apoptosis in human hepatocarcinoma cells. PLOS One, 8(8), e69534.","journal-title":"PLOS One"},{"issue":"12","key":"1376_CR71","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1002\/tox.22197","volume":"31","author":"R-M Fan","year":"2016","unstructured":"Fan, R.-M., Zhu, B.-Z., Huang, C.-P., Sheng, Z.-G., Mao, L., & Li, M.-X. (2016). Different modes of synergistic toxicities between metam\/copper (II) and metam\/zinc (II) in HepG2 cells: apoptosis vs. necrosis. Environmental Toxicology, 31(12), 1964\u20131973.","journal-title":"Environmental Toxicology"},{"issue":"39","key":"1376_CR72","doi-asserted-by":"publisher","first-page":"2003559","DOI":"10.1002\/adfm.202003559","volume":"30","author":"W-L Liu","year":"2020","unstructured":"Liu, W.-L., Zou, M.-Z., Qin, S.-Y., Cheng, Y.-J., Ma, Y.-H., Sun, Y.-X., & Zhang, X.-Z. (2020). Recent advances of cell membrane-coated nanomaterials for biomedical applications. Advanced Functional Materials, 30(39), 2003559.","journal-title":"Advanced Functional Materials"},{"issue":"11","key":"1376_CR73","doi-asserted-by":"publisher","first-page":"5701","DOI":"10.21873\/anticanres.11153","volume":"36","author":"S Gabriella","year":"2016","unstructured":"Gabriella, S., \u00c1Kos, C., Joseph, M., & Leonard, A. (2016). The anticancer activity of the old neuroleptic phenothiazine-type drug thioridazine. Anticancer Research, 36(11), 5701 p.","journal-title":"Anticancer Research"},{"key":"1376_CR74","doi-asserted-by":"publisher","unstructured":"Sharma, P., LaRosa, C., Antwi, J., Govindarajan, R., & Werbovetz, K. A. (2021). Imidazoles as potential anticancer agents: an update on recent studies. Molecules 26, https:\/\/doi.org\/10.3390\/molecules26144213.","DOI":"10.3390\/molecules26144213"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-024-01376-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-024-01376-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-024-01376-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T15:11:54Z","timestamp":1727795514000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-024-01376-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["1376"],"URL":"https:\/\/doi.org\/10.1007\/s12013-024-01376-9","relation":{},"ISSN":["1085-9195","1559-0283"],"issn-type":[{"value":"1085-9195","type":"print"},{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"18 June 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}