{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T05:17:43Z","timestamp":1740806263244,"version":"3.38.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005230","name":"the Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["cstc2019jcyj-msxmX0025"],"award-info":[{"award-number":["cstc2019jcyj-msxmX0025"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key R&D Program of China","award":["2017YFA0505700"],"award-info":[{"award-number":["2017YFA0505700"]}]},{"name":"the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2019PT320002"],"award-info":[{"award-number":["2019PT320002"]}]},{"name":"the National Key Program International Cooperation Project","award":["81820108015"],"award-info":[{"award-number":["81820108015"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81701361"],"award-info":[{"award-number":["81701361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-024-01509-0","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T05:01:50Z","timestamp":1727499710000},"page":"777-782","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Car1 Knockout Mice Exhibit Antidepressant-like Behaviors Accompanied with Gut Microbiota Disturbance"],"prefix":"10.1007","volume":"83","author":[{"given":"Chong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"1509_CR1","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/s0140-6736(18)31948-2","volume":"392","author":"GS Malhi","year":"2018","unstructured":"Malhi, G. S., & Mann, J. J. (2018). Depression. Lancet, 392, 2299\u20132312. https:\/\/doi.org\/10.1016\/s0140-6736(18)31948-2.","journal-title":"Lancet"},{"key":"1509_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.05.053","volume":"321","author":"C M\u00e9nard","year":"2016","unstructured":"M\u00e9nard, C., Hodes, G. E., & Russo, S. J. (2016). Pathogenesis of depression: Insights from human and rodent studies. Neuroscience, 321, 138\u2013162. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.05.053.","journal-title":"Neuroscience"},{"key":"1509_CR3","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/mp.2016.44","volume":"21","author":"P Zheng","year":"2016","unstructured":"Zheng, P., et al. (2016). Gut microbiome remodeling induces depression-like behaviors through a pathway mediated by the host\u2019s metabolism. Molecular Psychiatry, 21, 786\u2013796. https:\/\/doi.org\/10.1038\/mp.2016.44.","journal-title":"Molecular Psychiatry"},{"key":"1509_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0078-2","volume":"8","author":"B Li","year":"2018","unstructured":"Li, B., et al. (2018). Metabolite identification in fecal microbiota transplantation mouse livers and combined proteomics with chronic unpredictive mild stress mouse livers. Translational Psychiatry, 8, 34. https:\/\/doi.org\/10.1038\/s41398-017-0078-2.","journal-title":"Translational Psychiatry"},{"key":"1509_CR5","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan, J. F., & Dinan, T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13, 701\u2013712. https:\/\/doi.org\/10.1038\/nrn3346.","journal-title":"Nature Reviews Neuroscience"},{"key":"1509_CR6","doi-asserted-by":"publisher","first-page":"11859","DOI":"10.1073\/pnas.1614057113","volume":"113","author":"PW Tetteh","year":"2016","unstructured":"Tetteh, P. W., et al. (2016). Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America, 113, 11859\u201311864. https:\/\/doi.org\/10.1073\/pnas.1614057113.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"1509_CR7","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1189\/jlb.1212612","volume":"93","author":"K Mori","year":"2013","unstructured":"Mori, K., et al. (2013). Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3-CD4+CD25- T cells. Journal of Leukocyte Biology, 93, 963\u2013972. https:\/\/doi.org\/10.1189\/jlb.1212612.","journal-title":"Journal of Leukocyte Biology"},{"key":"1509_CR8","doi-asserted-by":"publisher","unstructured":"Cheng, K., et al. (2023). Upregulation of carbonic anhydrase 1 beneficial for depressive disorder. Acta Neuropathologica Communications 11, 59. https:\/\/doi.org\/10.1186\/s40478-023-01545-6.","DOI":"10.1186\/s40478-023-01545-6"},{"key":"1509_CR9","doi-asserted-by":"publisher","first-page":"e25263","DOI":"10.1371\/journal.pone.0025263","volume":"6","author":"H Tamaki","year":"2011","unstructured":"Tamaki, H., et al. (2011). Analysis of 16S rRNA amplicon sequencing options on Roche\/454 next-generation titanium sequencing platform. PloS One, 6, e25263. https:\/\/doi.org\/10.1371\/journal.pone.0025263.","journal-title":"PloS One"},{"key":"1509_CR10","doi-asserted-by":"publisher","first-page":"D633","DOI":"10.1093\/nar\/gkt1244","volume":"42","author":"JR Cole","year":"2014","unstructured":"Cole, J. R., et al. (2014). Ribosomal Database Project: data and tools for high throughput rRNA analysis. Nucleic Acids Research, 42, D633\u2013642,. https:\/\/doi.org\/10.1093\/nar\/gkt1244.","journal-title":"Nucleic Acids Research"},{"key":"1509_CR11","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.0030-1299.2005.13735.x","volume":"109","author":"CJ Keylock","year":"2005","unstructured":"Keylock, C. J. (2005). Simpson diversity and the Shannon-Wiener index as special cases of a generalized entropy. Oikos, 109, 203\u2013207. https:\/\/doi.org\/10.1111\/j.0030-1299.2005.13735.x.","journal-title":"Oikos"},{"key":"1509_CR12","doi-asserted-by":"publisher","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","volume":"71","author":"C Lozupone","year":"2005","unstructured":"Lozupone, C., & Knight, R. (2005). UniFrac: a new phylogenetic method for comparing microbial communities. Applied and Environmental Microbiology, 71, 8228\u20138235. https:\/\/doi.org\/10.1128\/AEM.71.12.8228-8235.2005.","journal-title":"Applied and Environmental Microbiology"},{"key":"1509_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60","volume":"12","author":"N Segata","year":"2011","unstructured":"Segata, N., et al. (2011). Metagenomic biomarker discovery and explanation. Genome Biology, 12, R60. https:\/\/doi.org\/10.1186\/gb-2011-12-6-r60.","journal-title":"Genome Biology"},{"key":"1509_CR14","doi-asserted-by":"publisher","first-page":"D261","DOI":"10.1093\/nar\/gku1223","volume":"43","author":"MY Galperin","year":"2015","unstructured":"Galperin, M. Y., Makarova, K. S., Wolf, Y. I., & Koonin, E. V. (2015). Expanded microbial genome coverage and improved protein family annotation in the COG database. Nucleic Acids Research, 43, D261\u2013269. https:\/\/doi.org\/10.1093\/nar\/gku1223.","journal-title":"Nucleic Acids Research"},{"key":"1509_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6423021","volume":"2017","author":"G Zhang","year":"2017","unstructured":"Zhang, G., & Yang, P. (2017). Bioinformatics Genes and Pathway Analysis for Chronic Neuropathic Pain after Spinal Cord Injury. BioMed Research International, 2017, 6423021. https:\/\/doi.org\/10.1155\/2017\/6423021.","journal-title":"BioMed Research International"},{"key":"1509_CR16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.4476","volume":"20","author":"TC Fung","year":"2017","unstructured":"Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017). Interactions between the microbiota, immune and nervous systems in health and disease. Nature Neuroscience, 20, 145\u2013155. https:\/\/doi.org\/10.1038\/nn.4476.","journal-title":"Nature Neuroscience"},{"key":"1509_CR17","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.cell.2016.10.027","volume":"167","author":"G Sharon","year":"2016","unstructured":"Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016). The Central Nervous System and the Gut Microbiome. Cell, 167, 915\u2013932. https:\/\/doi.org\/10.1016\/j.cell.2016.10.027.","journal-title":"Cell"},{"key":"1509_CR18","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan, J. F., et al. (2019). The Microbiota-Gut-Brain Axis. Physiological Reviews, 99, 1877\u20132013. https:\/\/doi.org\/10.1152\/physrev.00018.2018.","journal-title":"Physiological Reviews"},{"key":"1509_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1146\/annurev-psych-122216-011613","volume":"71","author":"JS Cruz-Pereira","year":"2020","unstructured":"Cruz-Pereira, J. S., et al. (2020). Depression\u2019s Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome. Annual Review of Psychology, 71, 49\u201378. https:\/\/doi.org\/10.1146\/annurev-psych-122216-011613.","journal-title":"Annual Review of Psychology"},{"key":"1509_CR20","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/s41380-019-0380-x","volume":"25","author":"J Pearson-Leary","year":"2020","unstructured":"Pearson-Leary, J., et al. (2020). The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats. Molecular Psychiatry, 25, 1068\u20131079. https:\/\/doi.org\/10.1038\/s41380-019-0380-x.","journal-title":"Molecular Psychiatry"},{"key":"1509_CR21","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.tins.2013.01.005","volume":"36","author":"JA Foster","year":"2013","unstructured":"Foster, J. A., & McVey Neufeld, K. A. (2013). Gut-brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, 36, 305\u2013312. https:\/\/doi.org\/10.1016\/j.tins.2013.01.005.","journal-title":"Trends in Neurosciences"},{"key":"1509_CR22","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1038\/s41380-018-0086-5","volume":"23","author":"M Soto","year":"2018","unstructured":"Soto, M., et al. (2018). Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism. Molecular Psychiatry, 23, 2287\u20132301. https:\/\/doi.org\/10.1038\/s41380-018-0086-5.","journal-title":"Molecular Psychiatry"},{"key":"1509_CR23","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.7150\/ijms.37322","volume":"16","author":"L Sun","year":"2019","unstructured":"Sun, L., et al. (2019). Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice. International Journal of Medical Sciences, 16, 1260\u20131270. https:\/\/doi.org\/10.7150\/ijms.37322.","journal-title":"International Journal of Medical Sciences"},{"key":"1509_CR24","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1039\/c8fo02599a","volume":"10","author":"J Song","year":"2019","unstructured":"Song, J., et al. (2019). Modulation of gut microbiota by chlorogenic acid pretreatment on rats with adrenocorticotropic hormone induced depression-like behavior. Food & Function, 10, 2947\u20132957. https:\/\/doi.org\/10.1039\/c8fo02599a.","journal-title":"Food & Function"},{"key":"1509_CR25","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.psyneuen.2019.02.025","volume":"104","author":"Z Hao","year":"2019","unstructured":"Hao, Z., Wang, W., Guo, R., & Liu, H. (2019). Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats. Psychoneuroendocrinology, 104, 132\u2013142. https:\/\/doi.org\/10.1016\/j.psyneuen.2019.02.025.","journal-title":"Psychoneuroendocrinology"},{"key":"1509_CR26","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1111\/nmo.12378","volume":"26","author":"A Naseribafrouei","year":"2014","unstructured":"Naseribafrouei, A., et al. (2014). Correlation between the human fecal microbiota and depression. Neurogastroenterology and Motility, 26, 1155\u20131162. https:\/\/doi.org\/10.1111\/nmo.12378.","journal-title":"Neurogastroenterology and Motility"},{"key":"1509_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108621","volume":"112","author":"HZ Zhu","year":"2019","unstructured":"Zhu, H. Z., et al. (2019). Xiaoyaosan improves depressive-like behavior in rats with chronic immobilization stress through modulation of the gut microbiota. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 112, 108621. https:\/\/doi.org\/10.1016\/j.biopha.2019.108621.","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"1509_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0031-4","volume":"7","author":"C Yang","year":"2017","unstructured":"Yang, C., et al. (2017). Possible role of the gut microbiota-brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model. Translational Psychiatry, 7, 1294. https:\/\/doi.org\/10.1038\/s41398-017-0031-4.","journal-title":"Translational Psychiatry"},{"key":"1509_CR29","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1136\/gutjnl-2011-301501","volume":"61","author":"IB Jeffery","year":"2012","unstructured":"Jeffery, I. B., et al. (2012). An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut, 61, 997\u20131006. https:\/\/doi.org\/10.1136\/gutjnl-2011-301501.","journal-title":"Gut"},{"key":"1509_CR30","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","volume":"444","author":"RE Ley","year":"2006","unstructured":"Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006). Microbial ecology: human gut microbes associated with obesity. Nature, 444, 1022\u20131023. https:\/\/doi.org\/10.1038\/4441022a.","journal-title":"Nature"},{"key":"1509_CR31","doi-asserted-by":"publisher","first-page":"10454","DOI":"10.18632\/aging.102469","volume":"11","author":"F Yu","year":"2019","unstructured":"Yu, F., et al. (2019). Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db\/db mice. Aging, 11, 10454\u201310467. https:\/\/doi.org\/10.18632\/aging.102469.","journal-title":"Aging"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-024-01509-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-024-01509-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-024-01509-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T06:25:42Z","timestamp":1740723942000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-024-01509-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,28]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["1509"],"URL":"https:\/\/doi.org\/10.1007\/s12013-024-01509-0","relation":{},"ISSN":["1559-0283"],"issn-type":[{"type":"electronic","value":"1559-0283"}],"subject":[],"published":{"date-parts":[[2024,9,28]]},"assertion":[{"value":"25 August 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}