{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:05:12Z","timestamp":1789423512901,"version":"build-2803163510"},"reference-count":141,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273174"],"award-info":[{"award-number":["81273174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2020H007"],"award-info":[{"award-number":["LH2020H007"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Construction Project of excellent Innovation Team for basic scientific research business fee of Heilongjiang provincial universities","award":["2022-KYYWF-0652"],"award-info":[{"award-number":["2022-KYYWF-0652"]}]},{"name":"the Jiamusi University National Fund cultivation project","award":["JMSUGPZR2023-018"],"award-info":[{"award-number":["JMSUGPZR2023-018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01686-6","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T18:40:22Z","timestamp":1740681622000},"page":"2651-2668","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Regulatory Roles and Therapeutic Potential of miR-122-5p in Hypoxic-Ischemic Brain Injury: Comprehensive Review"],"prefix":"10.1007","volume":"83","author":[{"given":"Abdulaziz S.","family":"Bamahel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"1686_CR1","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3390\/biom12111560","volume":"136","author":"DP Bartel","year":"2009","unstructured":"Bartel, D. P. (2009). MicroRNAs: Target recognition and regulatory functions. Cell, 136, 215\u2013233. https:\/\/doi.org\/10.3390\/biom12111560.","journal-title":"Cell"},{"key":"1686_CR2","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1016\/j.jmb.2013.03.007","volume":"425","author":"AM Gurtan","year":"2013","unstructured":"Gurtan, A. M., & Sharp, P. A. (2013). The role of miRNAs in regulating gene expression networks. Journal of Molecular Biology, 425, 3582\u20133600. https:\/\/doi.org\/10.1016\/j.jmb.2013.03.007.","journal-title":"Journal of Molecular Biology"},{"key":"1686_CR3","doi-asserted-by":"publisher","first-page":"865","DOI":"10.17219\/acem\/62915","volume":"26","author":"A Wojciechowska","year":"2017","unstructured":"Wojciechowska, A., Braniewska, A., & Kozar-Kami\u0144ska, K. (2017). MicroRNA in cardiovascular biology and disease. Advances in Clinical & Experimental Medicine, 26, 865\u2013874. https:\/\/doi.org\/10.17219\/acem\/62915.","journal-title":"Advances in Clinical & Experimental Medicine"},{"key":"1686_CR4","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1146\/annurev-biochem-060308-103103","volume":"79","author":"MR Fabian","year":"2010","unstructured":"Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010). Regulation of mRNA translation and stability by microRNAs. Annual Review of Biochemistry, 79, 351\u2013379. https:\/\/doi.org\/10.1146\/annurev-biochem-060308-103103.","journal-title":"Annual Review of Biochemistry"},{"key":"1686_CR5","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/cells9010220","volume":"9","author":"I Conti","year":"2020","unstructured":"Conti, I., Varano, G., Simioni, C., Laface, I., Milani, D., Rimondi, E., & Neri, L. M. (2020). miRNAs as influencers of cell\u2013cell communication in tumor microenvironment. Cells, 9, 220. https:\/\/doi.org\/10.3390\/cells9010220.","journal-title":"Cells"},{"key":"1686_CR6","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1016\/j.bbadis.2016.08.003","volume":"1862","author":"M Vijayan","year":"2016","unstructured":"Vijayan, M., & Reddy, P. H. (2016). Peripheral biomarkers of stroke: Focus on circulatory microRNAs. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1862, 1984\u20131993. https:\/\/doi.org\/10.1016\/j.bbadis.2016.08.003.","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"key":"1686_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.aqrep.2020.100401","volume":"52","author":"L Meng","year":"2020","unstructured":"Meng, L., Chen, Z., Jiang, Z., Huang, T., Hu, J., Luo, P., Zhang, H., Huang, M., Huang, L., Chen, Y., Lu, M., Xu, A. M., & Ying, S. (2020). MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN. Acta Biochimica et Biophysica Sinica, 52, 49\u201357. https:\/\/doi.org\/10.1016\/j.aqrep.2020.100401.","journal-title":"Acta Biochimica et Biophysica Sinica"},{"key":"1686_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/cbf.3460","volume":"38","author":"Z Ding","year":"2020","unstructured":"Ding, Z., Lin, J., Sun, Y., Cong, S., Liu, S., Zhang, Y., Chen, Q., & Chen, J. (2020). miR\u2010122\u20105p negatively regulates the transforming growth factor\u2010\u03b2\/Smad signaling pathway in skeletal muscle myogenesis. Cell Biochemistry and Function, 38, 231\u2013238. https:\/\/doi.org\/10.1002\/cbf.3460.","journal-title":"Cell Biochemistry and Function"},{"key":"1686_CR9","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s11010-020-03988-0","volume":"476","author":"Z Yang","year":"2021","unstructured":"Yang, Z., Wu, W., Ou, P., Wu, M., Zeng, F., Zhou, B., & Wu, S. (2021). MiR-122-5p knockdown protects against APAP-mediated liver injury through up-regulating NDRG3. Molecular and Cellular Biochemistry, 476, 1257\u20131267. https:\/\/doi.org\/10.1007\/s11010-020-03988-0.","journal-title":"Molecular and Cellular Biochemistry"},{"key":"1686_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","volume":"3","author":"C Esau","year":"2006","unstructured":"Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., & McKay, R. (2006). miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metabolism, 3, 87\u201398. https:\/\/doi.org\/10.1016\/j.cmet.2006.01.005.","journal-title":"Cell Metabolism"},{"key":"1686_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2020.115054","volume":"399","author":"Y Ge","year":"2020","unstructured":"Ge, Y., Tu, W., Li, J., Chen, X., Chen, Y., Xu, Y., Xu, Y., Wang, Y., & Liu, Y. (2020). MiR-122-5p increases radiosensitivity and aggravates radiation-induced rectal injury through CCAR1. Toxicology and Applied Pharmacology, 399, 115054. https:\/\/doi.org\/10.1016\/j.taap.2020.115054.","journal-title":"Toxicology and Applied Pharmacology"},{"key":"1686_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117851","volume":"256","author":"Z Lu","year":"2020","unstructured":"Lu, Z., Feng, H., Shen, X., He, R., Meng, H., Lin, W., & Geng, Q. (2020). MiR-122-5p protects against acute lung injury via regulation of DUSP4\/ERK signaling in pulmonary microvascular endothelial cells. Life Sciences, 256, 117851. https:\/\/doi.org\/10.1016\/j.lfs.2020.117851.","journal-title":"Life Sciences"},{"key":"1686_CR13","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1172\/JCI63539","volume":"122","author":"S-h Hsu","year":"2012","unstructured":"Hsu, S.-h, Wang, B., Kota, J., Yu, J., Costinean, S., Kutay, H., Yu, L., Bai, S., La Perle, K., & Chivukula, R. R. (2012). Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. The Journal of Clinical Investigation, 122, 2871\u20132883. https:\/\/doi.org\/10.1172\/JCI63539.","journal-title":"The Journal of Clinical Investigation"},{"key":"1686_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110713","volume":"123","author":"ME Al-Gazally","year":"2023","unstructured":"Al-Gazally, M. E., Khan, R., Imran, M., Ram\u00edrez-Coronel, A. A., Alshahrani, S. H., Altalbawy, F. M., Jalil, A. T., Romero-Parra, R. M., Zabibah, R. S., & Iqbal, M. S. (2023). The role and mechanism of action of microRNA-122 in cancer: focusing on the liver. International Immunopharmacology, 123, 110713. https:\/\/doi.org\/10.1016\/j.intimp.2023.110713.","journal-title":"International Immunopharmacology"},{"key":"1686_CR15","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1080\/01635581.2020.1783329","volume":"73","author":"A-HA Abdel-Wahab","year":"2021","unstructured":"Abdel-Wahab, A.-H. A., Effat, H., Mahrous, E. A., Ali, M. A., & Al-Shafie, T. A. (2021). A licorice roots extract induces apoptosis and cell cycle arrest and improves metabolism via regulating MiRNAs in liver cancer cells. Nutrition and Cancer, 73, 1047\u20131058. https:\/\/doi.org\/10.1080\/01635581.2020.1783329.","journal-title":"Nutrition and Cancer"},{"key":"1686_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.106978","volume":"138","author":"A Ismail","year":"2023","unstructured":"Ismail, A., El-Mahdy, H. A., Eldeib, M. G., & Doghish, A. S. (2023). miRNAs as cornerstones in diabetic microvascular complications. Molecular Genetics and Metabolism, 138, 106978. https:\/\/doi.org\/10.1016\/j.ymgme.2022.106978.","journal-title":"Molecular Genetics and Metabolism"},{"key":"1686_CR17","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1007\/s11064-023-04014-7","volume":"48","author":"N Yu","year":"2023","unstructured":"Yu, N., Tian, W., Liu, C., Zhang, P., Zhao, Y., Nan, C., Jin, Q., Li, X., & Liu, Y. (2023). miR-122-5p Promotes peripheral and central nervous system inflammation in a mouse model of intracerebral hemorrhage via disruption of the MLLT1\/PI3K\/AKT signaling. Neurochemical Research, 48, 3665\u20133682. https:\/\/doi.org\/10.1007\/s11064-023-04014-7.","journal-title":"Neurochemical Research"},{"key":"1686_CR18","doi-asserted-by":"publisher","first-page":"7978","DOI":"10.1002\/jcb.28075","volume":"120","author":"XM Zhou","year":"2019","unstructured":"Zhou, X. M., Liu, J., Wang, Y., & Zhang, M. H. (2019). Silencing of long noncoding RNA MEG3 enhances cerebral protection of dexmedetomidine against hypoxic-ischemic brain damage in neonatal mice by binding to miR-129-5p. Journal of Cellular Biochemistry, 120, 7978\u20137988. https:\/\/doi.org\/10.1002\/jcb.28075.","journal-title":"Journal of Cellular Biochemistry"},{"key":"1686_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.omtn.2020.01.009","volume":"20","author":"J Zhao","year":"2020","unstructured":"Zhao, J., He, L., & Yin, L. (2020). lncRNA NEAT1 Binds to MiR-339-5p to Increase HOXA1 and Alleviate Ischemic Brain Damage in Neonatal Mice. Molecular Therapy Nucleic Acids, 20, 117\u2013127. https:\/\/doi.org\/10.1016\/j.omtn.2020.01.009.","journal-title":"Molecular Therapy Nucleic Acids"},{"key":"1686_CR20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2174\/1567202614666171026114630","volume":"14","author":"J Lin","year":"2017","unstructured":"Lin, J., & Zheng, X. (2017). Salvianolate blocks apoptosis during myocardial infarction by down regulating miR-122-5p. Current Neurovascular Research, 14, 323\u2013329. https:\/\/doi.org\/10.2174\/1567202614666171026114630.","journal-title":"Current Neurovascular Research"},{"key":"1686_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122319","volume":"336","author":"X Li","year":"2024","unstructured":"Li, X., Zhang, J., Liu, G., Wu, G., Wang, R., & Zhang, J. (2024). High altitude hypoxia and oxidative stress: The new hope brought by free radical scavengers. Life Sciences, 336, 122319. https:\/\/doi.org\/10.1016\/j.lfs.2023.122319.","journal-title":"Life Sciences"},{"key":"1686_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ncl.2005.10.004","volume":"24","author":"I Harukuni","year":"2006","unstructured":"Harukuni, I., & Bhardwaj, A. (2006). Mechanisms of brain injury after global cerebral ischemia. Neurologic Clinics, 24, 1\u201321. https:\/\/doi.org\/10.1016\/j.ncl.2005.10.004.","journal-title":"Neurologic Clinics"},{"key":"1686_CR23","doi-asserted-by":"crossref","unstructured":"Fishbein G. A., Fishbein M. C., Wang J., Buja L. M. (2022) Myocardial ischemia and its complications. In: Cardiovascular pathology. Elsevier. pp. 407-445.","DOI":"10.1016\/B978-0-12-822224-9.00022-0"},{"key":"1686_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110668","volume":"107","author":"Z Dong","year":"2023","unstructured":"Dong, Z., Jia, L., Han, W., Wang, Y., Sheng, M., Ren, Y., Weng, Y., Li, H., & Yu, W. (2023). The protective effect of lncRNA NEAT1\/miR-122-5p\/Wnt1 axis on hippocampal damage in hepatic ischemic reperfusion young mice. Cellular Signalling, 107, 110668. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110668.","journal-title":"Cellular Signalling"},{"key":"1686_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10555-023-10129-8","volume":"43","author":"SF Jawad","year":"2024","unstructured":"Jawad, S. F., Altalbawy, F. M. A., Hussein, R. M., Fadhil, A. A., Jawad, M. A., Zabibah, R. S., Taraki, T. Y., Mohan, C. D., & Rangappa, K. S. (2024). The strict regulation of HIF-1\u03b1 by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies. Cancer Metastasis Reviews, 43, 5\u201327. https:\/\/doi.org\/10.1007\/s10555-023-10129-8.","journal-title":"Cancer Metastasis Reviews"},{"key":"1686_CR26","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/liv.12633","volume":"35","author":"T Csak","year":"2015","unstructured":"Csak, T., Bala, S., Lippai, D., Satishchandran, A., Catalano, D., Kodys, K., & Szabo, G. (2015). micro RNA\u2010122 regulates hypoxia\u2010inducible factor\u20101 and vimentin in hepatocytes and correlates with fibrosis in diet\u2010induced steatohepatitis. Liver International, 35, 532\u2013541. https:\/\/doi.org\/10.1111\/liv.12633.","journal-title":"Liver International"},{"key":"1686_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153481","volume":"83","author":"W Feng","year":"2021","unstructured":"Feng, W., Ying, Z., Ke, F., & Mei-Lin, X. (2021). Apigenin suppresses TGF-\u03b21-induced cardiac fibroblast differentiation and collagen synthesis through the downregulation of HIF-1\u03b1 expression by miR-122-5p. Phytomedicine, 83, 153481. https:\/\/doi.org\/10.1016\/j.phymed.2021.153481.","journal-title":"Phytomedicine"},{"key":"1686_CR28","doi-asserted-by":"publisher","first-page":"24302","DOI":"10.3390\/ijms161024302","volume":"16","author":"C Liu","year":"2015","unstructured":"Liu, C., Zhao, L., Han, S., Li, J., & Li, D. (2015). Identification and functional analysis of microRNAs in mice following focal cerebral ischemia injury. International Journal of Molecular Sciences, 16, 24302\u201324318. https:\/\/doi.org\/10.3390\/ijms161024302.","journal-title":"International Journal of Molecular Sciences"},{"key":"1686_CR29","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.2174\/15680266113139990106","volume":"13","author":"G Koutsis","year":"2013","unstructured":"Koutsis, G., Siasos, G., & Spengos, K. (2013). The emerging role of microRNA in stroke. Current Topics in Medicinal Chemistry, 13, 1573\u20131588. https:\/\/doi.org\/10.2174\/15680266113139990106.","journal-title":"Current Topics in Medicinal Chemistry"},{"key":"1686_CR30","doi-asserted-by":"publisher","first-page":"e99283","DOI":"10.1371\/journal.pone.0099283","volume":"9","author":"GC Jickling","year":"2014","unstructured":"Jickling, G. C., Ander, B. P., Zhan, X., Noblett, D., Stamova, B., & Liu, D. (2014). microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS ONE, 9, e99283. https:\/\/doi.org\/10.1371\/journal.pone.0099283.","journal-title":"PLoS ONE"},{"key":"1686_CR31","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.17576\/jsm-2021-5011-15","volume":"50","author":"H Yu","year":"2021","unstructured":"Yu, H., Xu, J., Zhu, P., & Zhang, C. (2021). MiR-122-5p Attenuates Endothelial-to-Mesenchymal Transition Induced by Oxygen and Glucose Deprivation\/Reperfusion. Sains Malaysiana, 50, 3313\u20133320. https:\/\/doi.org\/10.17576\/jsm-2021-5011-15.","journal-title":"Sains Malaysiana"},{"key":"1686_CR32","doi-asserted-by":"publisher","first-page":"12655","DOI":"10.26355\/eurrev_202012_24163","volume":"24","author":"K-W Li","year":"2020","unstructured":"Li, K.-W., Wang, S.-H., Wei, X., Hou, Y.-Z., & Li, Z.-H. (2020). Mechanism of miR-122-5p regulating the activation of PI3K-Akt-mTOR signaling pathway on the cell proliferation and apoptosis of osteosarcoma cells through targeting TP53 gene. European Review for Medical & Pharmacological Sciences, 24, 12655\u201312666. https:\/\/doi.org\/10.26355\/eurrev_202012_24163.","journal-title":"European Review for Medical & Pharmacological Sciences"},{"key":"1686_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04190-8","volume":"21","author":"K Li","year":"2023","unstructured":"Li, K., Gong, Q., Xiang, X.-D., Guo, G., Liu, J., Zhao, L., Li, J., Chen, N., Li, H., & Zhang, L.-J. (2023). HNRNPA2B1-mediated m6A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p\/PTEN axis. Journal of Translational Medicine, 21, 382. https:\/\/doi.org\/10.1186\/s12967-023-04190-8.","journal-title":"Journal of Translational Medicine"},{"key":"1686_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.892575","volume":"10","author":"Y Xu","year":"2022","unstructured":"Xu, Y., Ge, Y., Chen, X., Zhang, Y., Chen, H., Liu, D., Lu, Y., Liu, Y., & Tu, W. (2022). Hypoxic cell-derived extracellular vesicles aggravate rectal injury following radiotherapy via MiR-122-5p. Frontiers in Cell and Developmental Biology, 10, 892575. https:\/\/doi.org\/10.3389\/fcell.2022.892575.","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"1686_CR35","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1159\/000490078","volume":"47","author":"M Jiang","year":"2018","unstructured":"Jiang, M., Wang, H., Jin, M., Yang, X., Ji, H., Jiang, Y., Zhang, H., Wu, F., Wu, G., Lai, X., Cai, L., Hu, R., Xu, L., & Li, L. (2018). Exosomes from MiR-30d-5p-ADSCs reverse acute ischemic stroke-induced, autophagy-mediated brain injury by promoting M2 Microglial\/macrophage polarization. Cellular Physiology and Biochemistry, 47, 864\u2013878. https:\/\/doi.org\/10.1159\/000490078.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"1686_CR36","doi-asserted-by":"publisher","first-page":"391","DOI":"10.22038\/ijbms.2019.30224.7287","volume":"22","author":"R Yan","year":"2019","unstructured":"Yan, R., Tian, H., & Du, Z. (2019). Quercetin protects PC-12 cells against hypoxia injury by down-regulation of miR-122. Iranian Journal of Basic Medical Sciences, 22, 391\u2013398. https:\/\/doi.org\/10.22038\/ijbms.2019.30224.7287.","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"1686_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.109995","volume":"83","author":"M Budakoti","year":"2021","unstructured":"Budakoti, M., Panwar, A. S., Molpa, D., Singh, R. K., B\u00fcsselberg, D., Mishra, A. P., Coutinho, H. D. M., & Nigam, M. (2021). Micro-RNA: The darkhorse of cancer. Cellular Signalling, 83, 109995. https:\/\/doi.org\/10.1016\/j.cellsig.2021.109995.","journal-title":"Cellular Signalling"},{"key":"1686_CR38","doi-asserted-by":"publisher","first-page":"4663","DOI":"10.1093\/emboj\/cdf476","volume":"21","author":"Y Lee","year":"2002","unstructured":"Lee, Y., Jeon, K., Lee, J.-T., Kim, S., & Kim, V. N. (2002). MicroRNA maturation: Stepwise processing and subcellular localization. The EMBO Journal, 21, 4663\u20134670. https:\/\/doi.org\/10.1093\/emboj\/cdf476.","journal-title":"The EMBO Journal"},{"key":"1686_CR39","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1101\/gad.1262504","volume":"18","author":"J Han","year":"2004","unstructured":"Han, J., Lee, Y., Yeom, K. H., Kim, Y. K., Jin, H., & Kim, V. N. (2004). The Drosha-DGCR8 complex in primary microRNA processing. Genes & Development, 18, 3016\u20133027. https:\/\/doi.org\/10.1101\/gad.1262504.","journal-title":"Genes & Development"},{"key":"1686_CR40","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature08199","volume":"460","author":"HI Suzuki","year":"2009","unstructured":"Suzuki, H. I., Yamagata, K., Sugimoto, K., Iwamoto, T., Kato, S., & Miyazono, K. (2009). Modulation of microRNA processing by p53. Nature, 460, 529\u2013533. https:\/\/doi.org\/10.1038\/nature08199.","journal-title":"Nature"},{"key":"1686_CR41","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/ncb1577","volume":"9","author":"T Fukuda","year":"2007","unstructured":"Fukuda, T., Yamagata, K., Fujiyama, S., Matsumoto, T., Koshida, I., Yoshimura, K., Mihara, M., Naitou, M., Endoh, H., & Nakamura, T. (2007). DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs. Nature Cell Biology, 9, 604\u2013611. https:\/\/doi.org\/10.1038\/ncb1577.","journal-title":"Nature Cell Biology"},{"key":"1686_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cell.2004.06.017","volume":"118","author":"H Zhang","year":"2004","unstructured":"Zhang, H., Kolb, F. A., Jaskiewicz, L., Westhof, E., & Filipowicz, W. (2004). Single processing center models for human Dicer and bacterial RNase III. Cell, 118, 57\u201368. https:\/\/doi.org\/10.1016\/j.cell.2004.06.017.","journal-title":"Cell"},{"key":"1686_CR43","doi-asserted-by":"crossref","unstructured":"Kim, H., Kim, J., Yu, S., Lee, Y. Y., Park, J., Choi, R. J., Yoon, S. J., Kang, S. G., & Kim, V. N. (2020). A mechanism for microRNA arm switching regulated by uridylation. Molecular Cell 78, 1224\u20131236.e5. https:\/\/pubmed.ncbi.nlm.nih.gov\/32442398\/.","DOI":"10.1016\/j.molcel.2020.04.030"},{"key":"1686_CR44","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1101\/gad.1781009","volume":"23","author":"D Gatfield","year":"2009","unstructured":"Gatfield, D., Le Martelot, G., Vejnar, C. E., Gerlach, D., Schaad, O., Fleury-Olela, F., Ruskeep\u00e4\u00e4, A. L., Oresic, M., Esau, C. C., Zdobnov, E. M., & Schibler, U. (2009). Integration of microRNA miR-122 in hepatic circadian gene expression. Genes & Development, 23, 1313\u20131326. https:\/\/doi.org\/10.1101\/gad.1781009.","journal-title":"Genes & Development"},{"key":"1686_CR45","doi-asserted-by":"publisher","first-page":"55","DOI":"10.20517\/evcna.2021.04","volume":"2","author":"L Xiao","year":"2021","unstructured":"Xiao, L., Hareendran, S., & Loh, Y. P. (2021). Function of exosomes in neurological disorders and brain tumors. Extracellular Vesicles and Circulating Nucleic Acids, 2, 55 https:\/\/doi.org\/10.20517\/evcna.2021.04.","journal-title":"Extracellular Vesicles and Circulating Nucleic Acids"},{"key":"1686_CR46","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/WNR.0000000000000752","volume":"28","author":"Y Yang","year":"2017","unstructured":"Yang, Y., Shen, Z., Sun, W., Gao, S., Li, Y., & Guo, Y. (2017). The role of miR-122-5p in negatively regulating T-box brain 1 expression on the differentiation of mouse bone mesenchymal stem cells. Neuroreport, 28, 367\u2013374. https:\/\/doi.org\/10.1097\/WNR.0000000000000752.","journal-title":"Neuroreport"},{"key":"1686_CR47","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1159\/000486067","volume":"44","author":"F Zhi","year":"2017","unstructured":"Zhi, F., Shao, N., Xue, L., Xu, Y., Kang, X., Yang, Y., & Xia, Y. (2017). Characteristic MicroRNA Expression Induced by \u03b4-Opioid Receptor Activation in the Rat Liver Under Prolonged Hypoxia. Cellular Physiology and Biochemistry, 44, 2296\u20132309. https:\/\/doi.org\/10.1159\/000486067.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"1686_CR48","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1055\/a-2013-0336","volume":"43","author":"J Zhang","year":"2023","unstructured":"Zhang, J., Fu, L., Zhang, J., Zhou, B., Tang, Y., Zhang, Z., & Gu, T. (2023). Inhibition of MicroRNA-122-5p relieves myocardial ischemia-reperfusion injury via SOCS1. Hamostaseologie, 43, 271\u2013280. https:\/\/doi.org\/10.1055\/a-2013-0336.","journal-title":"Hamostaseologie"},{"key":"1686_CR49","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1007\/s10571-021-01085-4","volume":"42","author":"W Shan","year":"2022","unstructured":"Shan, W., Ge, H., Chen, B., Huang, L., Zhu, S., & Zhou, Y. (2022). Upregulation of miR-499a-5p decreases cerebral ischemia\/reperfusion injury by targeting PDCD4. Cellular and Molecular Neurobiology, 42, 2157\u20132170. https:\/\/doi.org\/10.1007\/s10571-021-01085-4.","journal-title":"Cellular and Molecular Neurobiology"},{"key":"1686_CR50","doi-asserted-by":"publisher","first-page":"e86872","DOI":"10.1371\/journal.pone.0086872","volume":"9","author":"AM Liu","year":"2014","unstructured":"Liu, A. M., Xu, Z., Shek, F. H., Wong, K.-F., Lee, N. P., Poon, R. T., Chen, J., & Luk, J. M. (2014). miR-122 targets pyruvate kinase M2 and affects metabolism of hepatocellular carcinoma. PLoS ONE, 9, e86872. https:\/\/doi.org\/10.1371\/journal.pone.0086872.","journal-title":"PLoS ONE"},{"key":"1686_CR51","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.3390\/cells9010220","volume":"28","author":"C Coulouarn","year":"2009","unstructured":"Coulouarn, C., Factor, V. M., Andersen, J. B., Durkin, M. E., & Thorgeirsson, S. S. (2009). Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene, 28, 3526\u20133536. https:\/\/doi.org\/10.3390\/cells9010220.","journal-title":"Oncogene"},{"key":"1686_CR52","doi-asserted-by":"publisher","first-page":"377","DOI":"10.21037\/atm.2016.08.22","volume":"4","author":"SP Guenther","year":"2016","unstructured":"Guenther, S. P., & Schrepfer, S. (2016). miR-126: A potential new key player in hypoxia and reperfusion? Annals of Translational Medicine, 4, 377. https:\/\/doi.org\/10.21037\/atm.2016.08.22.","journal-title":"Annals of Translational Medicine"},{"key":"1686_CR53","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.2174\/0929867322666150209154755","volume":"22","author":"Y Yang","year":"2015","unstructured":"Yang, Y., K. Sandhu, H., Zhi, F., Hua, F., Wu, M., & Xia, Y. (2015). Effects of hypoxia and ischemia on microRNAs in the brain. Current Medicinal Chemistry, 22, 1292\u20131301. https:\/\/doi.org\/10.2174\/0929867322666150209154755.","journal-title":"Current Medicinal Chemistry"},{"key":"1686_CR54","doi-asserted-by":"publisher","first-page":"e22922","DOI":"10.1016\/j.heliyon.2023.e22922","volume":"9","author":"H Zhao","year":"2023","unstructured":"Zhao, H., Duan, R., Wang, Q., Hu, X., Zhao, Q., Wu, W., Jiang, R., Gong, S., Wang, L., & Liu, J. (2023). MiR-122-5p as a potential regulator of pulmonary vascular wall cell in idiopathic pulmonary arterial hypertension. Heliyon, 9, e22922. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e22922.","journal-title":"Heliyon"},{"key":"1686_CR55","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.yexcr.2018.04.027","volume":"369","author":"D Guo","year":"2018","unstructured":"Guo, D., Ma, J., Li, T., & Yan, L. (2018). Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-\u03baB pathway by targeting FOXO3. Experimental Cell Research, 369, 34\u201342. https:\/\/doi.org\/10.1016\/j.yexcr.2018.04.027.","journal-title":"Experimental Cell Research"},{"key":"1686_CR56","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s12012-020-09603-4","volume":"20","author":"Y Liu","year":"2020","unstructured":"Liu, Y., Song, J.-W., Lin, J.-Y., Miao, R., & Zhong, J.-C. (2020). Roles of microRNA-122 in cardiovascular fibrosis and related diseases. Cardiovascular Toxicology, 20, 463\u2013473.","journal-title":"Cardiovascular Toxicology"},{"key":"1686_CR57","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s00018-023-04755-2","volume":"80","author":"M Omorou","year":"2023","unstructured":"Omorou, M., Huang, Y., Gao, M., Mu, C., Xu, W., Han, Y., & Xu, H. (2023). The forkhead box O3 (FOXO3): a key player in the regulation of ischemia and reperfusion injury. Cellular and Molecular Life Sciences, 80, 102. https:\/\/doi.org\/10.1007\/s00018-023-04755-2.","journal-title":"Cellular and Molecular Life Sciences"},{"key":"1686_CR58","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3390\/ddc2010009","volume":"2","author":"Z Melo","year":"2023","unstructured":"Melo, Z., Palomino, J., Franco-Acevedo, A., Garc\u00eda, D., Gonz\u00e1lez-Gonz\u00e1lez, R., Verdugo-Molinares, M., Portilla-de Buen, E., Moreno-Carranza, B., Fuentes-Orozco, C., & Barbosa-Camacho, F. (2023). Pharmacological blockade of TGF-Beta reduces renal interstitial fibrosis in a chronic ischemia\u2013reperfusion animal model. Drugs Drug Candidates 2023, 2, 137\u2013147.","journal-title":"Drugs Drug Candidates 2023"},{"key":"1686_CR59","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/cbf.3460","volume":"38","author":"Z Ding","year":"2020","unstructured":"Ding, Z., Lin, J., Sun, Y., Cong, S., Liu, S., Zhang, Y., Chen, Q., & Chen, J. (2020). miR-122-5p negatively regulates the transforming growth factor-\u03b2\/Smad signaling pathway in skeletal muscle myogenesis. Cell Biochemistry and Function, 38, 231\u2013238. https:\/\/doi.org\/10.1002\/cbf.3460.","journal-title":"Cell Biochemistry and Function"},{"key":"1686_CR60","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3892\/etm.2018.6962","volume":"17","author":"B Cheng","year":"2019","unstructured":"Cheng, B., Zhu, Q., Lin, W., & Wang, L. (2019). MicroRNA-122 inhibits epithelial-mesenchymal transition of hepatic stellate cells induced by the TGF-\u03b21\/Smad signaling pathway. Experimental and Therapeutic Medicine, 17, 284\u2013290. https:\/\/doi.org\/10.3892\/etm.2018.6962.","journal-title":"Experimental and Therapeutic Medicine"},{"key":"1686_CR61","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.1080\/21655979.2022.2038448","volume":"13","author":"Y Che","year":"2022","unstructured":"Che, Y., He, J., Li, X., Wu, D., Zhang, Y., & Yuan, G. (2022). Overexpression of microRNA-381-3p ameliorates hypoxia\/ischemia-induced neuronal damage and microglial inflammation via regulating the CC chemokine receptor type 2\/nuclear transcription factor-kappa B axis. Bioengineered, 13, 6839\u20136855. https:\/\/doi.org\/10.1080\/21655979.2022.2038448.","journal-title":"Bioengineered"},{"key":"1686_CR62","doi-asserted-by":"publisher","first-page":"5703","DOI":"10.3390\/ijms24065703","volume":"24","author":"Y Liang","year":"2023","unstructured":"Liang, Y., Tang, X., Zhang, X., Cao, C., Yu, M., & Wan, M. (2023). Adipose mesenchymal stromal cell-derived exosomes carrying MiR-122-5p antagonize the inhibitory effect of dihydrotestosterone on hair follicles by targeting the TGF-\u03b21\/SMAD3 signaling pathway. International Journal of Molecular Sciences, 24, 5703. https:\/\/doi.org\/10.3390\/ijms24065703.","journal-title":"International Journal of Molecular Sciences"},{"key":"1686_CR63","doi-asserted-by":"publisher","first-page":"e18238","DOI":"10.1016\/j.heliyon.2023.e18238","volume":"9","author":"H Wu","year":"2023","unstructured":"Wu, H., Fu, Q., Li, Z., Wei, H., & Qin, S. (2023). Inhibition of microRNA-122 alleviates pyroptosis by targeting dual-specificity phosphatase 4 in myocardial ischemia\/reperfusion injury. Heliyon, 9, e18238. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18238.","journal-title":"Heliyon"},{"key":"1686_CR64","doi-asserted-by":"publisher","first-page":"4165","DOI":"10.2147\/JIR.S422114","volume":"16","author":"C He","year":"2023","unstructured":"He, C., Li, Z., Yang, M., Yu, W., Luo, R., Zhou, J., He, J., Chen, Q., Song, Z., & Cheng, S. (2023). Non-coding RNA in microglia activation and neuroinflammation in Alzheimer\u2019s disease. Journal of Inflammation Research, 16, 4165\u20134211. https:\/\/doi.org\/10.2147\/JIR.S422114.","journal-title":"Journal of Inflammation Research"},{"key":"1686_CR65","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.21873\/anticanres.16634","volume":"43","author":"P Ren","year":"2023","unstructured":"Ren, P., Wu, N., Fu, S., Wang, W., Li, Q., & Cheng, Q. (2023). miR-122-5p restrains pancreatic cancer cell growth and causes apoptosis by negatively regulating ASCT2. Anticancer Research, 43, 4379\u20134388. https:\/\/doi.org\/10.21873\/anticanres.16634.","journal-title":"Anticancer Research"},{"key":"1686_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.154725","volume":"249","author":"R Mirzaei","year":"2023","unstructured":"Mirzaei, R., Karampoor, S., & Korotkova, N. L. (2023). The emerging role of miRNA-122 in infectious diseases: Mechanisms and potential biomarkers. Pathology-Research and Practice, 249, 154725. https:\/\/doi.org\/10.1016\/j.prp.2023.154725.","journal-title":"Pathology-Research and Practice"},{"key":"1686_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2023.110594","volume":"115","author":"Z Wang","year":"2023","unstructured":"Wang, Z., Xu, F., Zhao, X., Zhang, Y., Wang, X., Zhang, Z., Yang, L. Z., Badshah, J. S., Xu, B., & Xie, R. (2023). Expression analysis and targets prediction of microRNAs in OGD\/R treated astrocyte-derived exosomes by smallRNA sequencing. Genomics, 115, 110594. https:\/\/doi.org\/10.1016\/j.ygeno.2023.110594.","journal-title":"Genomics"},{"key":"1686_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2023.100199","volume":"78","author":"X-J Yu","year":"2023","unstructured":"Yu, X.-J., Zhang, T., Wei, Z.-Z., Gu, B., Guo, T., Jiang, W.-J., Shen, Y.-Q., Wang, D., Wang, Q., & Wang, J. (2023). Abnormal expression of miRNA-122 in cerebral infarction and related mechanism of regulating vascular endothelial cell proliferation and apoptosis by targeting CCNG1. Clinics, 78, 100199. https:\/\/doi.org\/10.1016\/j.clinsp.2023.100199.","journal-title":"Clinics"},{"key":"1686_CR69","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-02868-z","volume":"23","author":"M Faramin Lashkarian","year":"2023","unstructured":"Faramin Lashkarian, M., Hashemipour, N., Niaraki, N., Soghala, S., Moradi, A., Sarhangi, S., Hatami, M., Aghaei-Zarch, F., Khosravifar, M., & Mohammadzadeh, A. (2023). MicroRNA-122 in human cancers: from mechanistic to clinical perspectives. Cancer Cell International, 23, 29. https:\/\/doi.org\/10.1186\/s12935-023-02868-z.","journal-title":"Cancer Cell International"},{"key":"1686_CR70","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01790-y","volume":"29","author":"S Feng","year":"2024","unstructured":"Feng, S., Wu, Z., Zheng, X., Shao, Z., Lin, Q., & Sun, S. (2024). Abnormal levels of expression of microRNAs in peripheral blood of patients with traumatic brain injury are induced by microglial activation and correlated with severity of injury. European Journal of Medical Research, 29, 188. https:\/\/doi.org\/10.1186\/s40001-024-01790-y.","journal-title":"European Journal of Medical Research"},{"key":"1686_CR71","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3389\/fimmu.2020.00759","volume":"11","author":"Y Kong","year":"2020","unstructured":"Kong, Y., Li, S., Cheng, X., Ren, H., Zhang, B., Ma, H., Li, M., & Zhang, X.-A. (2020). Brain ischemia significantly alters microRNA expression in human peripheral blood natural killer cells. Frontiers in immunology, 11, 759. https:\/\/doi.org\/10.3389\/fimmu.2020.00759.","journal-title":"Frontiers in immunology"},{"key":"1686_CR72","doi-asserted-by":"publisher","first-page":"9582","DOI":"10.3390\/ijms21249582","volume":"21","author":"L Moreno-Garc\u00eda","year":"2020","unstructured":"Moreno-Garc\u00eda, L., L\u00f3pez-Royo, T., Calvo, A. C., Toivonen, J. M., de la Torre, M., Moreno-Mart\u00ednez, L., Molina, N., Aparicio, P., Zaragoza, P., & Manzano, R. (2020). Competing endogenous RNA networks as biomarkers in neurodegenerative diseases. International Journal of Molecular Sciences, 21, 9582. https:\/\/doi.org\/10.3390\/ijms21249582.","journal-title":"International Journal of Molecular Sciences"},{"key":"1686_CR73","doi-asserted-by":"crossref","unstructured":"You H., Pei Z. (2023) MicroRNAs as potential biomarkers in Huntington\u2019s Disease. In: Biomarkers for Huntington\u2019s Disease: Improving Clinical Outcomes. Springer. pp. 387-402.","DOI":"10.1007\/978-3-031-32815-2_16"},{"key":"1686_CR74","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","volume":"87","author":"JA Smith","year":"2012","unstructured":"Smith, J. A., Das, A., Ray, S. K., & Banik, N. L. (2012). Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Research Bulletin, 87, 10\u201320. https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.004.","journal-title":"Brain Research Bulletin"},{"key":"1686_CR75","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/sj.cdd.4401837","volume":"13","author":"M Mattson","year":"2006","unstructured":"Mattson, M., & Meffert, M. (2006). Roles for NF-\u03baB in nerve cell survival, plasticity, and disease. Cell Death & Differentiation, 13, 852\u2013860. https:\/\/doi.org\/10.1038\/sj.cdd.4401837.","journal-title":"Cell Death & Differentiation"},{"key":"1686_CR76","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3390\/pathogens8040290","volume":"8","author":"S Fochi","year":"2019","unstructured":"Fochi, S., Ciminale, V., Trabetti, E., Bertazzoni, U., D\u2019Agostino, D. M., Zipeto, D., & Romanelli, M. G. (2019). NF-\u03baB and MicroRNA deregulation mediated by HTLV-1 tax and HBZ. Pathogens, 8, 290. https:\/\/doi.org\/10.3390\/pathogens8040290.","journal-title":"Pathogens"},{"key":"1686_CR77","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI11916","volume":"107","author":"MP Mattson","year":"2001","unstructured":"Mattson, M. P., & Camandola, S. (2001). NF-\u03baB in neuronal plasticity and neurodegenerative disorders. The Journal of Clinical Investigation, 107, 247\u2013254. https:\/\/doi.org\/10.1172\/JCI11916.","journal-title":"The Journal of Clinical Investigation"},{"key":"1686_CR78","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1007\/s11064-005-6961-x","volume":"30","author":"MP Mattson","year":"2005","unstructured":"Mattson, M. P. (2005). NF-\u03baB in the survival and plasticity of neurons. Neurochemical Research, 30, 883\u2013893. https:\/\/doi.org\/10.1007\/s11064-005-6961-x.","journal-title":"Neurochemical Research"},{"key":"1686_CR79","doi-asserted-by":"publisher","first-page":"17214","DOI":"10.1074\/jbc.M112.445965","volume":"288","author":"G-Z Tao","year":"2013","unstructured":"Tao, G.-Z., Lehwald, N., Jang, K. Y., Baek, J., Xu, B., Omary, M. B., & Sylvester, K. G. (2013). Wnt\/\u03b2-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. Journal of Biological Chemistry, 288, 17214\u201317224. https:\/\/doi.org\/10.1074\/jbc.M112.445965.","journal-title":"Journal of Biological Chemistry"},{"key":"1686_CR80","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/0886022X.2022.2039194","volume":"44","author":"L Cheng","year":"2022","unstructured":"Cheng, L., Qiu, X., He, L., & Liu, L. (2022). MicroRNA-122-5p ameliorates tubular injury in diabetic nephropathy via FIH-1\/HIF-1\u03b1 pathway. Renal Failure, 44, 293\u2013303. https:\/\/doi.org\/10.1080\/0886022X.2022.2039194.","journal-title":"Renal Failure"},{"key":"1686_CR81","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/ddr.21928","volume":"83","author":"F Wang","year":"2022","unstructured":"Wang, F., Zhang, J., Niu, G., Weng, J., Zhang, Q., Xie, M., Li, C., & Sun, K. (2022). Apigenin inhibits isoproterenol\u2010induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR\u2010122\u20105p\/155\u20105p expressions. Drug Development Research, 83, 1003\u20131015. https:\/\/doi.org\/10.1002\/ddr.21928.","journal-title":"Drug Development Research"},{"key":"1686_CR82","doi-asserted-by":"publisher","DOI":"10.1038\/srep21340","volume":"6","author":"A Ambade","year":"2016","unstructured":"Ambade, A., Satishchandran, A., & Szabo, G. (2016). Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1\u03b1 activation. Scientific Reports, 6, 21340. https:\/\/doi.org\/10.1038\/srep21340.","journal-title":"Scientific Reports"},{"key":"1686_CR83","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.3390\/biom5042363","volume":"5","author":"A Loffreda","year":"2015","unstructured":"Loffreda, A., Rigamonti, A., Barabino, S. M., & Lenzken, S. C. (2015). RNA-binding proteins in the regulation of miRNA activity: a focus on neuronal functions. Biomolecules, 5, 2363\u20132387. https:\/\/doi.org\/10.3390\/biom5042363.","journal-title":"Biomolecules"},{"key":"1686_CR84","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1188574","volume":"17","author":"KA Ko\u0142osowska","year":"2023","unstructured":"Ko\u0142osowska, K. A., Schratt, G., & Winterer, J. (2023). microRNA-dependent regulation of gene expression in GABAergic interneurons. Frontiers in Cellular Neuroscience, 17, 1188574. https:\/\/doi.org\/10.3389\/fncel.2023.1188574.","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"1686_CR85","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3389\/fcell.2020.00273","volume":"8","author":"B Salvatori","year":"2020","unstructured":"Salvatori, B., Biscarini, S., & Morlando, M. (2020). Non-coding RNAs in nervous system development and disease. Frontiers in Cell and Developmental Biology, 8, 273. https:\/\/doi.org\/10.3389\/fcell.2020.00273.","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"1686_CR86","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2174\/0929867327666200121122910","volume":"28","author":"RC Segaran","year":"2021","unstructured":"Segaran, R. C., Chan, L. Y., Wang, H., Sethi, G., & Tang, F. R. (2021). Neuronal development-related miRNAs as biomarkers for Alzheimer\u2019s disease, depression, schizophrenia and ionizing radiation exposure. Current Medicinal Chemistry, 28, 19\u201352. https:\/\/doi.org\/10.2174\/0929867327666200121122910.","journal-title":"Current Medicinal Chemistry"},{"key":"1686_CR87","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.3390\/biom12111560","volume":"12","author":"BS Basavarajappa","year":"2022","unstructured":"Basavarajappa, B. S., & Subbanna, S. (2022). Molecular insights into epigenetics and cannabinoid receptors. Biomolecules, 12, 1560. https:\/\/doi.org\/10.3390\/biom12111560.","journal-title":"Biomolecules"},{"key":"1686_CR88","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/cbf.3763","volume":"41","author":"S Guha","year":"2023","unstructured":"Guha, S., Sesili, S., Mir, I. H., & Thirunavukkarasu, C. (2023). Epigenetics and mitochondrial dysfunction insights into the impact of the progression of non\u2010alcoholic fatty liver disease. Cell Biochemistry and Function, 41, 4\u201319. https:\/\/doi.org\/10.1002\/cbf.3763.","journal-title":"Cell Biochemistry and Function"},{"key":"1686_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113290","volume":"153","author":"D Li","year":"2022","unstructured":"Li, D., Li, Y., Yang, S., Lu, J., Jin, X., & Wu, M. (2022). Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics. Biomedicine & Pharmacotherapy, 153, 113290. https:\/\/doi.org\/10.1016\/j.biopha.2022.113290.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1686_CR90","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.3390\/cells11182852","volume":"11","author":"S Chen","year":"2022","unstructured":"Chen, S., Wang, Y., Li, D., Wang, H., Zhao, X., Yang, J., Chen, L., Guo, M., Zhao, J., & Chen, C. (2022). Mechanisms controlling microRNA expression in tumor. Cells, 11, 2852. https:\/\/doi.org\/10.3390\/cells11182852.","journal-title":"Cells"},{"key":"1686_CR91","first-page":"4167","volume":"13","author":"Q Li","year":"2021","unstructured":"Li, Q., Nong, A., Huang, Z., He, K., Jia, Y., & Huang, Y. (2021). Exosomes containing miR-122-5p secreted by LPS-induced neutrophils regulate the apoptosis and permeability of brain microvascular endothelial cells by targeting OCLN. American Journal of Translational Research, 13, 4167.","journal-title":"American Journal of Translational Research"},{"key":"1686_CR92","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1080\/21655979.2021.1926201","volume":"12","author":"W Song","year":"2021","unstructured":"Song, W., Zhang, T., Yang, N., Zhang, T., Wen, R., & Liu, C. (2021). Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1. Bioengineered, 12, 1902\u20131915. https:\/\/doi.org\/10.1080\/21655979.2021.1926201.","journal-title":"Bioengineered"},{"key":"1686_CR93","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cbpb.2015.02.002","volume":"184","author":"X Wang","year":"2015","unstructured":"Wang, X., Shao, F., Yu, J., Jiang, H., Gong, D., & Gu, Z. (2015). MicroRNA-122 targets genes related to liver metabolism in chickens. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 184, 29\u201335. https:\/\/doi.org\/10.1016\/j.cbpb.2015.02.002.","journal-title":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"},{"key":"1686_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.aqrep.2020.100401","volume":"17","author":"R-H Lu","year":"2020","unstructured":"Lu, R.-H., Jia, S.-Z., Yang, F., Qin, C.-B., Zhang, Y.-R., Meng, X.-L., Yan, X., Feng, J.-C., & Nie, G.-X. (2020). The function of miR-122 in the lipid metabolism and immunity of grass carp (Ctenopharyngodon idellus). Aquaculture Reports, 17, 100401.","journal-title":"Aquaculture Reports"},{"key":"1686_CR95","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1530\/EJE-14-0867","volume":"172","author":"R Wang","year":"2015","unstructured":"Wang, R., Hong, J., Cao, Y., Shi, J., Gu, W., Ning, G., Zhang, Y., & Wang, W. (2015). Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults. European Journal of Endocrinology, 172, 291\u2013300. https:\/\/doi.org\/10.1530\/EJE-14-0867.","journal-title":"European Journal of Endocrinology"},{"key":"1686_CR96","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/nyas.14566","volume":"1495","author":"KM Citrin","year":"2021","unstructured":"Citrin, K. M., Fern\u00e1ndez\u2010Hernando, C., & Su\u00e1rez, Y. (2021). MicroRNA regulation of cholesterol metabolism. Annals of the New York Academy of Sciences, 1495, 55\u201377. https:\/\/doi.org\/10.1111\/nyas.14566.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"1686_CR97","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1161\/ATVBAHA.112.300144","volume":"33","author":"C Fern\u00e1ndez-Hernando","year":"2013","unstructured":"Fern\u00e1ndez-Hernando, C., Ram\u00edrez, C. M., Goedeke, L., & Su\u00e1rez, Y. (2013). MicroRNAs in metabolic disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 33, 178\u2013185. https:\/\/doi.org\/10.1161\/ATVBAHA.112.300144.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"1686_CR98","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1172\/JCI63539","volume":"122","author":"W-C Tsai","year":"2012","unstructured":"Tsai, W.-C., Hsu, S.-D., Hsu, C.-S., Lai, T.-C., Chen, S.-J., Shen, R., Huang, Y., Chen, H.-C., Lee, C.-H., & Tsai, T.-F. (2012). MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. The Journal of Clinical Investigation, 122, 2884\u20132897. https:\/\/doi.org\/10.1172\/JCI63539.","journal-title":"The Journal of Clinical Investigation"},{"key":"1686_CR99","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/s41440-021-00837-5","volume":"45","author":"E Mishima","year":"2022","unstructured":"Mishima, E. (2022). The E2F1-IREB2 axis regulates neuronal ferroptosis in cerebral ischemia. Hypertension Research, 45, 1085\u20131086. https:\/\/doi.org\/10.1038\/s41440-021-00837-5.","journal-title":"Hypertension Research"},{"key":"1686_CR100","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1115996","volume":"10","author":"R Mahmoudi-Lamouki","year":"2023","unstructured":"Mahmoudi-Lamouki, R., Kadkhoda, S., Hussen, B. M., & Ghafouri-Fard, S. (2023). Emerging role of miRNAs in the regulation of ferroptosis. Frontiers in Molecular Biosciences, 10, 1115996. https:\/\/doi.org\/10.3389\/fmolb.2023.1115996.","journal-title":"Frontiers in Molecular Biosciences"},{"key":"1686_CR101","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3390\/cells12010090","volume":"12","author":"Y Sun","year":"2022","unstructured":"Sun, Y., Li, Q., Guo, H., & He, Q. (2022). Ferroptosis and iron metabolism after intracerebral hemorrhage. Cells, 12, 90. https:\/\/doi.org\/10.3390\/cells12010090.","journal-title":"Cells"},{"key":"1686_CR102","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/nature04478","volume":"438","author":"P Carmeliet","year":"2005","unstructured":"Carmeliet, P. (2005). Angiogenesis in life, disease and medicine. Nature, 438, 932\u2013936. https:\/\/doi.org\/10.1038\/nature04478.","journal-title":"Nature"},{"key":"1686_CR103","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6202","volume":"5","author":"R Rupaimoole","year":"2014","unstructured":"Rupaimoole, R., Wu, S. Y., Pradeep, S., Ivan, C., Pecot, C. V., Gharpure, K. M., Nagaraja, A. S., Armaiz-Pena, G. N., McGuire, M., & Zand, B. (2014). Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nature Communications, 5, 5202. https:\/\/doi.org\/10.1038\/ncomms6202.","journal-title":"Nature Communications"},{"key":"1686_CR104","first-page":"203","volume":"60","author":"T Veikkola","year":"2000","unstructured":"Veikkola, T., Karkkainen, M., Claesson-Welsh, L., & Alitalo, K. (2000). Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Research, 60, 203\u2013212.","journal-title":"Cancer Research"},{"key":"1686_CR105","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/1947601911423031","volume":"2","author":"M Shibuya","year":"2011","unstructured":"Shibuya, M. (2011). Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti-and pro-angiogenic therapies. Genes & Cancer, 2, 1097\u20131105. https:\/\/doi.org\/10.1177\/1947601911423031.","journal-title":"Genes & Cancer"},{"key":"1686_CR106","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1038\/s41374-020-0454-z","volume":"100","author":"X Shi","year":"2020","unstructured":"Shi, X., Ma, W., Pan, Y., Li, Y., Wang, H., Pan, S., Tian, Y., Xu, C., & Li, L. (2020). MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice. Laboratory Investigation, 100, 1564\u20131574. https:\/\/doi.org\/10.1038\/s41374-020-0454-z.","journal-title":"Laboratory Investigation"},{"key":"1686_CR107","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3892\/etm.2022.11559","volume":"24","author":"Z Luo","year":"2022","unstructured":"Luo, Z., Gong, T., Li, W., & Tao, W. (2022). LncRNA Meg3 promotes oxygen and glucose deprivation injury by decreasing angiogenesis in hBMECs by targeting the miR\u2011122\u20115p\/NDRG3 axis. Experimental and Therapeutic Medicine, 24, 622 https:\/\/doi.org\/10.3892\/etm.2022.11559.","journal-title":"Experimental and Therapeutic Medicine"},{"key":"1686_CR108","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.26355\/eurrev_201808_15631","volume":"22","author":"C-Q Ding","year":"2018","unstructured":"Ding, C.-Q., Deng, W.-S., Yin, X.-F., & Ding, X.-D. (2018). MiR-122 inhibits cell proliferation and induces apoptosis by targeting runt-related transcription factors 2 in human glioma. European Review for Medical & Pharmacological Sciences, 22, 4925\u20134933. https:\/\/doi.org\/10.26355\/eurrev_201808_15631.","journal-title":"European Review for Medical & Pharmacological Sciences"},{"key":"1686_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/liv.12633","volume":"20","author":"C Dai","year":"2020","unstructured":"Dai, C., Zhang, Y., Xu, Z., & Jin, M. (2020). MicroRNA-122-5p inhibits cell proliferation, migration and invasion by targeting CCNG1 in pancreatic ductal adenocarcinoma. Cancer Cell International, 20, 1\u201318. https:\/\/doi.org\/10.1111\/liv.12633.","journal-title":"Cancer Cell International"},{"key":"1686_CR110","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/j.1478-3231.2011.02750.x","volume":"32","author":"J Xu","year":"2012","unstructured":"Xu, J., Zhu, X., Wu, L., Yang, R., Yang, Z., Wang, Q., & Wu, F. (2012). Micro RNA\u2010122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt\/\u03b2\u2010catenin pathway. Liver international, 32, 752\u2013760. https:\/\/doi.org\/10.1111\/j.1478-3231.2011.02750.x.","journal-title":"Liver international"},{"key":"1686_CR111","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.jhep.2014.10.004","volume":"62","author":"S Bandiera","year":"2015","unstructured":"Bandiera, S., Pfeffer, S., Baumert, T. F., & Zeisel, M. B. (2015). miR-122\u2013a key factor and therapeutic target in liver disease. Journal of Hepatology, 62, 448\u2013457. https:\/\/doi.org\/10.1016\/j.jhep.2014.10.004.","journal-title":"Journal of Hepatology"},{"key":"1686_CR112","doi-asserted-by":"publisher","DOI":"10.1038\/srep16566","volume":"5","author":"N Liu","year":"2015","unstructured":"Liu, N., Jiang, F., He, T.-L., Zhang, J.-K., Zhao, J., Wang, C., Jiang, G.-X., Cao, L.-P., Kang, P.-C., & Zhong, X.-Y. (2015). The roles of microRNA-122 overexpression in inhibiting proliferation and invasion and stimulating apoptosis of human cholangiocarcinoma cells. Scientific Reports, 5, 16566. https:\/\/doi.org\/10.1038\/srep16566.","journal-title":"Scientific Reports"},{"key":"1686_CR113","doi-asserted-by":"publisher","first-page":"e915825","DOI":"10.12659\/MSM.915825","volume":"26","author":"X Xue","year":"2020","unstructured":"Xue, X., Wang, H., & Su, J. (2020). Inhibition of MiR-122 decreases cerebral ischemia-reperfusion injury by upregulating DJ-1-phosphatase and tensin homologue deleted on chromosome 10 (PTEN)\/Phosphonosinol-3 kinase (PI3K)\/AKT. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e915825\u2013915821. https:\/\/doi.org\/10.12659\/MSM.915825.","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"1686_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111853","volume":"131","author":"J Lyu","year":"2024","unstructured":"Lyu, J., Sheng, M., Cao, Y., Jia, L., Zhang, C., Weng, Y., & Yu, W. (2024). Ischemia and reperfusion-injured liver-derived exosomes elicit acute lung injury through miR-122-5p regulated alveolar macrophage polarization. International Immunopharmacology, 131, 111853. https:\/\/doi.org\/10.1016\/j.intimp.2024.111853.","journal-title":"International Immunopharmacology"},{"key":"1686_CR115","doi-asserted-by":"publisher","first-page":"e001223","DOI":"10.1136\/openhrt-2019-001223","volume":"7","author":"S Singh","year":"2020","unstructured":"Singh, S., de Ronde, M. W., Kok, M. G., Beijk, M. A., De Winter, R. J., van der Wal, A. C., Sondermeijer, B. M., Meijers, J. C., Creemers, E. E., & Pinto-Sietsma, S.-J. (2020). MiR-223-3p and miR-122-5p as circulating biomarkers for plaque instability. Open Heart, 7, e001223. https:\/\/doi.org\/10.1136\/openhrt-2019-001223.","journal-title":"Open Heart"},{"key":"1686_CR116","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122241","volume":"334","author":"H Liang","year":"2023","unstructured":"Liang, H., Tang, L. Y., Ge, H. Y., Chen, M. M., Lu, S. Y., Zhang, H. X., Shen, C. L., Shen, Y., Fei, J., & Wang, Z. G. (2023). Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP\/PKA\/CREB\/BCL2 signaling pathway. Life Sciences, 334, 122241. https:\/\/doi.org\/10.1016\/j.lfs.2023.122241.","journal-title":"Life Sciences"},{"key":"1686_CR117","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/bs.ircmb.2017.03.006","volume":"333","author":"T Bertero","year":"2017","unstructured":"Bertero, T., Rezzonico, R., Pottier, N., & Mari, B. (2017). Impact of microRNAs in the cellular response to hypoxia. International Review of Cell and Molecular Biology, 333, 91\u2013158. https:\/\/doi.org\/10.1016\/bs.ircmb.2017.03.006.","journal-title":"International Review of Cell and Molecular Biology"},{"key":"1686_CR118","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1172\/JCI84433","volume":"126","author":"CT Taylor","year":"2016","unstructured":"Taylor, C. T., Doherty, G., Fallon, P. G., & Cummins, E. P. (2016). Hypoxia-dependent regulation of inflammatory pathways in immune cells. The Journal of Clinical Investigation, 126, 3716\u20133724. https:\/\/doi.org\/10.1172\/JCI84433.","journal-title":"The Journal of Clinical Investigation"},{"key":"1686_CR119","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.biochi.2018.10.011","volume":"157","author":"J Hu","year":"2019","unstructured":"Hu, J., Wu, H., Wang, D., Yang, Z., & Dong, J. (2019). LncRNA ANRIL promotes NLRP3 inflammasome activation in uric acid nephropathy through miR-122-5p\/BRCC3 axis. Biochimie, 157, 102\u2013110. https:\/\/doi.org\/10.1016\/j.biochi.2018.10.011.","journal-title":"Biochimie"},{"key":"1686_CR120","doi-asserted-by":"publisher","first-page":"6162","DOI":"10.1073\/pnas.1814139116","volume":"116","author":"Y Wang","year":"2019","unstructured":"Wang, Y., Liang, H., Jin, F., Yan, X., Xu, G., Hu, H., Liang, G., Zhan, S., Hu, X., Zhao, Q., Liu, Y., Jiang, Z. Y., Zhang, C. Y., Chen, X., & Zen, K. (2019). Injured liver-released miRNA-122 elicits acute pulmonary inflammation via activating alveolar macrophage TLR7 signaling pathway. Proceedings of the National Academy of Sciences of the United States of America, 116, 6162\u20136171. https:\/\/doi.org\/10.1073\/pnas.1814139116.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"1686_CR121","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1080\/13813455.2019.1640744","volume":"127","author":"Y Hu","year":"2021","unstructured":"Hu, Y., Du, G., Li, G., Peng, X., Zhang, Z., & Zhai, Y. (2021). The miR-122 inhibition alleviates lipid accumulation and inflammation in NAFLD cell model. Archives of Physiology and Biochemistry, 127, 385\u2013389. https:\/\/doi.org\/10.1080\/13813455.2019.1640744.","journal-title":"Archives of Physiology and Biochemistry"},{"key":"1686_CR122","doi-asserted-by":"publisher","first-page":"350419","DOI":"10.1155\/2013\/350419","volume":"2013","author":"J Qiu","year":"2013","unstructured":"Qiu, J., Zhou, X.-y, Zhou, X.-g, Cheng, R., Liu, H.-y, & Li, Y. (2013). Neuroprotective effects of microRNA-210 on hypoxic-ischemic encephalopathy. BioMed Research International, 2013, 350419. https:\/\/doi.org\/10.1155\/2013\/350419.","journal-title":"BioMed Research International"},{"key":"1686_CR123","doi-asserted-by":"publisher","first-page":"940","DOI":"10.7150\/jca.17496","volume":"8","author":"B Li","year":"2017","unstructured":"Li, B., He, L., Zuo, D., He, W., Wang, Y., Zhang, Y., Liu, W., & Yuan, Y. (2017). Mutual regulation of MiR-199a-5p and HIF-1\u03b1 modulates the Warburg effect in hepatocellular carcinoma. Journal of Cancer, 8, 940. https:\/\/doi.org\/10.7150\/jca.17496.","journal-title":"Journal of Cancer"},{"key":"1686_CR124","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.803445","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu, Y., Peng, X., Du, G., Zhang, Z., Zhai, Y., Xiong, X., & Luo, X. (2022). MicroRNA-122-5p inhibition improves inflammation and oxidative stress damage in dietary-induced non-alcoholic fatty liver disease through targeting FOXO3. Frontiers in Physiology, 13, 803445. https:\/\/doi.org\/10.3389\/fphys.2022.803445.","journal-title":"Frontiers in Physiology"},{"key":"1686_CR125","doi-asserted-by":"publisher","first-page":"8830","DOI":"10.26355\/eurrev_201812_16651","volume":"22","author":"XH Qu","year":"2018","unstructured":"Qu, X. H., & Zhang, K. (2018). MiR-122 regulates cell apoptosis and ROS by targeting DJ-1 in renal ischemic reperfusion injury rat models. European Review for Medical and Pharmacological Sciences, 22, 8830\u20138838. https:\/\/doi.org\/10.26355\/eurrev_201812_16651.","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"1686_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173374","volume":"883","author":"JJ Song","year":"2020","unstructured":"Song, J. J., Yang, M., Liu, Y., Song, J. W., Wang, J., Chi, H. J., Liu, X. Y., Zuo, K., Yang, X. C., & Zhong, J. C. (2020). MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling. European Journal of Pharmacology, 883, 173374. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173374.","journal-title":"European Journal of Pharmacology"},{"key":"1686_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.121192","volume":"312","author":"M Li","year":"2023","unstructured":"Li, M., Ying, M., Gu, S., Zhou, Z., & Zhao, R. (2023). SIRT6 inhibits hypoxia-induced pulmonary arterial smooth muscle cells proliferation via HIF-1\u03b1\/PDK4 signaling. Life Sciences, 312, 121192. https:\/\/doi.org\/10.1016\/j.lfs.2022.121192.","journal-title":"Life Sciences"},{"key":"1686_CR128","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.peptides.2016.10.005","volume":"86","author":"R Xu","year":"2016","unstructured":"Xu, R., Zhang, Z. Z., Chen, L. J., Yu, H. M., Guo, S. J., Xu, Y. L., Oudit, G. Y., Zhang, Y., Chang, Q., Song, B., Chen, D. R., Zhu, D. L., & Zhong, J. C. (2016). Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-\u03b2-catenin signaling. Peptides, 86, 85\u201394. https:\/\/doi.org\/10.1016\/j.peptides.2016.10.005.","journal-title":"Peptides"},{"key":"1686_CR129","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.3892\/mmr.2018.9124","volume":"18","author":"X Zhang","year":"2018","unstructured":"Zhang, X., & Jing, W. (2018). Upregulation of miR\u2011122 is associated with cardiomyocyte apoptosis in atrial fibrillation. Molecular Medicine Reports, 18, 1745\u20131751. https:\/\/doi.org\/10.3892\/mmr.2018.9124.","journal-title":"Molecular Medicine Reports"},{"key":"1686_CR130","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.bbrc.2019.09.035","volume":"519","author":"G Song","year":"2019","unstructured":"Song, G., Zhu, L., Ruan, Z., Wang, R., & Shen, Y. (2019). MicroRNA-122 promotes cardiomyocyte hypertrophy via targeting FoxO3. Biochemical and Biophysical Research Communications, 519, 682\u2013688. https:\/\/doi.org\/10.1016\/j.bbrc.2019.09.035.","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"1686_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12013-024-01322-9","volume":"82","author":"T Barati","year":"2024","unstructured":"Barati, T., Mirzaei, Z., Ebrahimi, A., Shekari Khaniani, M., & Mansoori Derakhshan, S. (2024). miR\u2010449a: A promising biomarker and therapeutic target in cancer and other diseases. Cell Biochemistry and Biophysics, 82, 1\u201322.","journal-title":"Cell Biochemistry and Biophysics"},{"key":"1686_CR132","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00881-9","volume":"116","author":"J Gregorius","year":"2021","unstructured":"Gregorius, J., Wang, C., Stambouli, O., Hussner, T., Qi, Y., Tertel, T., B\u00f6rger, V., Mohamud Yusuf, A., Hagemann, N., Yin, D., Dittrich, R., Mouloud, Y., Mairinger, F. D., Magraoui, F. E., Popa-Wagner, A., Kleinschnitz, C., Doeppner, T. R., Gunzer, M., Meyer, H. E., Giebel, B., & Hermann, D. M. (2021). Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice. Basic Research in Cardiology, 116, 40. https:\/\/doi.org\/10.1007\/s00395-021-00881-9.","journal-title":"Basic Research in Cardiology"},{"key":"1686_CR133","doi-asserted-by":"publisher","DOI":"10.1038\/srep15501","volume":"5","author":"AD Vliegenthart","year":"2015","unstructured":"Vliegenthart, A. D., Shaffer, J. M., Clarke, J. I., Peeters, L. E., Caporali, A., Bateman, D. N., Wood, D. M., Dargan, P. I., Craig, D. G., Moore, J. K., Thompson, A. I., Henderson, N. C., Webb, D. J., Sharkey, J., Antoine, D. J., Park, B. K., Bailey, M. A., Lader, E., Simpson, K. J., & Dear, J. W. (2015). Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury. Scientific Reports, 5, 15501. https:\/\/doi.org\/10.1038\/srep15501.","journal-title":"Scientific Reports"},{"key":"1686_CR134","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1080\/17460441.2020.1765770","volume":"15","author":"M Segal","year":"2020","unstructured":"Segal, M., & Slack, F. J. (2020). Challenges identifying efficacious miRNA therapeutics for cancer. Expert Opinion on Drug Discovery, 15, 987\u2013992. https:\/\/doi.org\/10.1080\/17460441.2020.1765770.","journal-title":"Expert Opinion on Drug Discovery"},{"key":"1686_CR135","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1177\/0271678X15610786","volume":"36","author":"DZ Liu","year":"2016","unstructured":"Liu, D. Z., Jickling, G. C., Ander, B. P., Hull, H., Zhan, X., Cox, C., Shroff, N., Dykstra-Aiello, C., Stamova, B., & Sharp, F. R. (2016). Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. Journal of Cerebral Blood Flow & Metabolism, 36, 1374\u20131383. https:\/\/doi.org\/10.1177\/0271678X15610786.","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"key":"1686_CR136","doi-asserted-by":"publisher","first-page":"74526","DOI":"10.18632\/oncotarget.12931","volume":"7","author":"Y Zeng","year":"2016","unstructured":"Zeng, Y., Lv, Y., Tao, L., Ma, J., Zhang, H., Xu, H., Xiao, B., Shi, Q., Ma, K., & Chen, L. (2016). G6PC3, ALDOA and CS induction accompanies mir-122 down-regulation in the mechanical asphyxia and can serve as hypoxia biomarkers. Oncotarget, 7, 74526. https:\/\/doi.org\/10.18632\/oncotarget.12931.","journal-title":"Oncotarget"},{"key":"1686_CR137","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jad.2023.04.094","volume":"334","author":"M Krivosova","year":"2023","unstructured":"Krivosova, M., Adamcakova, J., Kaadt, E., Mumm, B. H., Dvorska, D., Brany, D., Dankova, Z., Dohal, M., Samec, M., Ferencova, N., Tonhajzerova, I., Ondrejka, I., Hrtanek, I., Hutka, P., Oppa, M., Mokry, J., & Elfving, B. (2023). The VEGF protein levels, miR-101-3p, and miR-122-5p are dysregulated in plasma from adolescents with major depression. Journal of Affective Disorders, 334, 60\u201368. https:\/\/doi.org\/10.1016\/j.jad.2023.04.094.","journal-title":"Journal of Affective Disorders"},{"key":"1686_CR138","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/s11064-021-03232-1","volume":"46","author":"Z Wei","year":"2021","unstructured":"Wei, Z., Liu, J., Xie, H., Wang, B., Wu, J., & Zhu, Z. (2021). MiR-122-5p mitigates inflammation, reactive oxygen species and SH-SY5Y apoptosis by targeting CPEB1 after spinal cord injury via the PI3K\/AKT signaling pathway. Neurochemical Research, 46, 992\u20131005. https:\/\/doi.org\/10.1007\/s11064-021-03232-1.","journal-title":"Neurochemical Research"},{"key":"1686_CR139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1225482","volume":"14","author":"H Wang","year":"2023","unstructured":"Wang, H., Li, Y., Jiang, S., Liu, N., Zhou, Q., Li, Q., Chen, Z., Lin, Y., Chen, C., & Deng, Y. (2023). LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p\/PKC\u03b7 Axis. Frontiers in Immunology, 14, 1225482. https:\/\/doi.org\/10.3389\/fimmu.2023.1225482.","journal-title":"Frontiers in Immunology"},{"key":"1686_CR140","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/bcp.13136","volume":"83","author":"L Rivoli","year":"2017","unstructured":"Rivoli, L., Vliegenthart, A. D., de Potter, C. M., van Bragt, J. J., Tzoumas, N., Gallacher, P., Farrah, T. E., Dhaun, N., & Dear, J. W. (2017). The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122. British Journal of Clinical Pharmacology, 83, 584\u2013592. https:\/\/doi.org\/10.1111\/bcp.13136.","journal-title":"British Journal of Clinical Pharmacology"},{"key":"1686_CR141","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104325","volume":"111","author":"L Gong","year":"2019","unstructured":"Gong, L., Chang, H., & Xu, H. (2019). RETRACTED: LncRNA MALAT1 knockdown alleviates oxygen-glucose deprivation and reperfusion induced cardiomyocyte apoptotic death by regulating miR-122. Experimental and Molecular Pathology, 111, 104325. https:\/\/doi.org\/10.1016\/j.yexmp.2019.104325.","journal-title":"Experimental and Molecular Pathology"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01686-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01686-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01686-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T08:21:09Z","timestamp":1757146869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01686-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":141,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["1686"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01686-6","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"27 January 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}