{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:17:59Z","timestamp":1789600679484,"version":"build-2803163510"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01723-4","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T09:07:40Z","timestamp":1742288860000},"page":"2779-2791","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeting the NLRP3 by Natural Compounds: Therapeutic Strategies to Mitigate Doxorubicin-Induced Cardiotoxicity"],"prefix":"10.1007","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-9750","authenticated-orcid":false,"given":"Dareuosh","family":"Shackebaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8592-7651","authenticated-orcid":false,"given":"Kheirollah","family":"Yari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-1408","authenticated-orcid":false,"given":"Nader","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-8089","authenticated-orcid":false,"given":"Sara","family":"Gorgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-8766","authenticated-orcid":false,"given":"Fatemeh","family":"Yarmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"1723_CR1","doi-asserted-by":"publisher","first-page":"111708","DOI":"10.1016\/j.biopha.2021.111708","volume":"139","author":"PS Rawat","year":"2021","unstructured":"Rawat, P. S., Jaiswal, A., Khurana, A., Bhatti, J. S., & Navik, U. (2021). Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 139, 111708. https:\/\/doi.org\/10.1016\/j.biopha.2021.111708.","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"issue":"2","key":"1723_CR2","doi-asserted-by":"publisher","first-page":"e23261","DOI":"10.1002\/jbt.23261","volume":"37","author":"F Yarmohammadi","year":"2023","unstructured":"Yarmohammadi, F., Ebrahimian, Z., & Karimi, G. (2023). MicroRNAs target the PI3K\/Akt\/p53 and the Sirt1\/Nrf2 signaling pathways in doxorubicin\u2010induced cardiotoxicity. Journal of Biochemical and Molecular Toxicology, 37(2), e23261.","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"key":"1723_CR3","doi-asserted-by":"publisher","first-page":"105383","DOI":"10.1016\/j.phrs.2020.105383","volume":"164","author":"F Yarmohammadi","year":"2021","unstructured":"Yarmohammadi, F., Rezaee, R., Haye, A. W., & Karimi, G. (2021). Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review. Pharmacological Research, 164, 105383. https:\/\/doi.org\/10.1016\/j.phrs.2020.105383.","journal-title":"Pharmacological Research"},{"key":"1723_CR4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.yjmcc.2019.08.009","volume":"136","author":"L Meng","year":"2019","unstructured":"Meng, L., Lin, H., Zhang, J., Lin, N., Sun, Z., Gao, F., Luo, H., Ni, T., Luo, W., Chi, J., & Guo, H. (2019). Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3. Journal of Molecular and Cellular Cardiology, 136, 15\u201326. https:\/\/doi.org\/10.1016\/j.yjmcc.2019.08.009.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"5","key":"1723_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s12012-020-09576-4","volume":"20","author":"S Wei","year":"2020","unstructured":"Wei, S., Ma, W., Li, X., Jiang, C., Sun, T., Li, Y., Zhang, B., & Li, W. (2020). Involvement of ROS\/NLRP3 Inflammasome Signaling Pathway in Doxorubicin-Induced Cardiotoxicity. Cardiovascular Toxicology, 20(5), 507\u2013519. https:\/\/doi.org\/10.1007\/s12012-020-09576-4.","journal-title":"Cardiovascular Toxicology"},{"key":"1723_CR6","doi-asserted-by":"publisher","first-page":"4938287","DOI":"10.1155\/2023\/4938287","volume":"2023","author":"Z Ping","year":"2023","unstructured":"Ping, Z., Fangfang, T., Yuliang, Z., Xinyong, C., Lang, H., Fan, H., Jun, M., & Liang, S. (2023). Oxidative stress and pyroptosis in doxorubicin-induced heart failure and atrial fibrillation. Oxidative Medicine and Cellular Longevity, 2023, 4938287. https:\/\/doi.org\/10.1155\/2023\/4938287.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"1723_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep26489","volume":"6","author":"M Kobayashi","year":"2016","unstructured":"Kobayashi, M., Usui, F., Karasawa, T., Kawashima, A., Kimura, H., Mizushina, Y., Shirasuna, K., Mizukami, H., Kasahara, T., & Hasebe, N. (2016). NLRP3 deficiency reduces macrophage interleukin-10 production and enhances the susceptibility to doxorubicin-induced cardiotoxicity. Scientific Reports, 6(1), 1\u201311.","journal-title":"Scientific Reports"},{"issue":"1","key":"1723_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00204-020-02876-2","volume":"95","author":"ZH Maayah","year":"2021","unstructured":"Maayah, Z. H., Takahara, S., & Dyck, J. R. B. (2021). The beneficial effects of reducing NLRP3 inflammasome activation in the cardiotoxicity and the anti-cancer effects of doxorubicin. Archives of toxicology, 95(1), 1\u20139. https:\/\/doi.org\/10.1007\/s00204-020-02876-2.","journal-title":"Archives of toxicology"},{"key":"1723_CR9","doi-asserted-by":"publisher","unstructured":"Bontempo, P., De Masi, L., & Rigano, D. (2023, June). Functional Properties of Natural Products and Human Health. Nutrients. Switzerland. https:\/\/doi.org\/10.3390\/nu15132961","DOI":"10.3390\/nu15132961"},{"key":"1723_CR10","doi-asserted-by":"publisher","first-page":"155880","DOI":"10.1016\/j.phymed.2024.155880","volume":"132","author":"X Pu","year":"2024","unstructured":"Pu, X., Zhang, Q., Liu, J., Wang, Y., Guan, X., Wu, Q., Liu, Z., Liu, R., & Chang, X. (2024). Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions. Phytomedicine, 132, 155880. https:\/\/doi.org\/10.1016\/j.phymed.2024.155880.","journal-title":"Phytomedicine"},{"issue":"5","key":"1723_CR11","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1002\/ptr.8177","volume":"38","author":"X Chang","year":"2024","unstructured":"Chang, X., Zhang, Q., Huang, Y., Liu, J., Wang, Y., Guan, X., Wu, Q., Liu, Z., & Liu, R. (2024). Quercetin inhibits necroptosis in cardiomyocytes after ischemia-reperfusion via DNA-PKcs-SIRT5-orchestrated mitochondrial quality control. Phytotherapy research: PTR, 38(5), 2496\u20132517. https:\/\/doi.org\/10.1002\/ptr.8177.","journal-title":"Phytotherapy research: PTR"},{"key":"1723_CR12","doi-asserted-by":"publisher","first-page":"1049888","DOI":"10.3389\/fonc.2022.1049888","volume":"12","author":"Y Nan","year":"2022","unstructured":"Nan, Y., Su, H., Zhou, B., & Liu, S. (2022). The function of natural compounds in important anticancer mechanisms. Frontiers in Oncology, 12, 1049888. https:\/\/doi.org\/10.3389\/fonc.2022.1049888.","journal-title":"Frontiers in Oncology"},{"issue":"8","key":"1723_CR13","doi-asserted-by":"publisher","first-page":"624","DOI":"10.2174\/0113816128295053240207090928","volume":"30","author":"H Singhai","year":"2024","unstructured":"Singhai, H., Rathee, S., Jain, S. K., & Patil, U. K. (2024). The Potential of Natural Products in the Management of Cardiovascular Disease. Current Pharmaceutical Design, 30(8), 624\u2013638. https:\/\/doi.org\/10.2174\/0113816128295053240207090928.","journal-title":"Current Pharmaceutical Design"},{"issue":"13","key":"1723_CR14","doi-asserted-by":"publisher","first-page":"5145","DOI":"10.7150\/ijbs.96748","volume":"20","author":"J Wang","year":"2024","unstructured":"Wang, J., Zhuang, H., Yang, X., Guo, Z., Zhou, K., Liu, N., An, Y., Chen, Y., Zhang, Z., Wang, M., Chen, J., Li, C., & Chang, X. (2024). Exploring the mechanism of ferroptosis induction by sappanone A in cancer: Insights into the mitochondrial dysfunction mediated by NRF2\/xCT\/GPX4 axis. International Journal of Biological Sciences, 20(13), 5145\u20135161. https:\/\/doi.org\/10.7150\/ijbs.96748.","journal-title":"International Journal of Biological Sciences"},{"issue":"8","key":"1723_CR15","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.1039\/d2fo03904d","volume":"14","author":"S Hu","year":"2023","unstructured":"Hu, S., Liu, B., Yang, M., Mao, S., Ju, H., Liu, Z., Huang, M., & Wu, G. (2023). Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2\/HO-1 pathway. Food and Function, 14(8), 3849\u20133862. https:\/\/doi.org\/10.1039\/d2fo03904d.","journal-title":"Food and Function"},{"issue":"4","key":"1723_CR16","doi-asserted-by":"publisher","first-page":"752","DOI":"10.21037\/cdt-19-707","volume":"10","author":"W Yu","year":"2020","unstructured":"Yu, W., Qin, X., Zhang, Y., Qiu, P., Wang, L., Zha, W., & Ren, J. (2020). Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K\/Akt\/mTOR-dependent manner. Cardiovascular Diagnosis and Therapy, 10(4), 752. https:\/\/doi.org\/10.21037\/cdt-19-707.","journal-title":"Cardiovascular Diagnosis and Therapy"},{"key":"1723_CR17","doi-asserted-by":"publisher","unstructured":"Zou, H., Zhang, M., Yang, X., Shou, H., Chen, Z., Zhu, Q., Luo T., Mou X., & Chen, X. (2024). Cynaroside regulates the AMPK\/SIRT3\/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis. Journal of Zhejiang University: Science B. https:\/\/doi.org\/10.1631\/jzus.B2300691","DOI":"10.1631\/jzus.B2300691"},{"issue":"8","key":"1723_CR18","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.12122\/j.issn.1673-4254.2022.08.13","volume":"42","author":"F Xiong","year":"2022","unstructured":"Xiong, F., Liu, R., Li, Y., & Sun, N. (2022). Honokiol reduces doxorubicin-induced cardiotoxicity in vitro by inhibiting pyroptosis via activating AMPK\/Nrf2 signaling. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 42(8), 1205\u20131211. https:\/\/doi.org\/10.12122\/j.issn.1673-4254.2022.08.13.","journal-title":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University"},{"issue":"9","key":"1723_CR19","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1002\/ptr.7900","volume":"37","author":"S Wei","year":"2023","unstructured":"Wei, S., Ma, W., Jiang, C., Liu, J., Liu, J., Zhang, B., & Li, W. (2023). Hyperoside prevents doxorubicin-induced cardiotoxicity by inhibiting NOXs\/ROS\/NLRP3 inflammasome signaling pathway. Phytotherapy Research, 37(9), 4196\u20134209. https:\/\/doi.org\/10.1002\/ptr.7900.","journal-title":"Phytotherapy Research"},{"key":"1723_CR20","doi-asserted-by":"publisher","unstructured":"\u00d6zt\u00fcrk, K. H., & \u00dcnal, G. \u00d6. (2022). Novel splice\u2011site variants c.393G>A, c.278_2A>G in exon 2 and Q705K variant in exon 3 of NLRP3 gene are associated with bipolar I disorder. Molecular Medicine Reports, 26(3). https:\/\/doi.org\/10.3892\/mmr.2022.12810","DOI":"10.3892\/mmr.2022.12810"},{"issue":"6","key":"1723_CR21","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.ajpath.2022.03.003","volume":"192","author":"RML Colunga Biancatelli","year":"2022","unstructured":"Colunga Biancatelli, R. M. L., Solopov, P. A., & Catravas, J. D. (2022). The inflammasome NLR family pyrin domain-containing protein 3 (NLRP3) as a novel therapeutic target for idiopathic pulmonary fibrosis. The American Journal of Pathology, 192(6), 837\u2013846. https:\/\/doi.org\/10.1016\/j.ajpath.2022.03.003.","journal-title":"The American Journal of Pathology"},{"key":"1723_CR22","doi-asserted-by":"publisher","first-page":"879021","DOI":"10.3389\/fnagi.2022.879021","volume":"14","author":"HM Blevins","year":"2022","unstructured":"Blevins, H. M., Xu, Y., Biby, S., & Zhang, S. (2022). The NLRP3 inflammasome pathway: A review of mechanisms and inhibitors for the treatment of inflammatory diseases. Frontiers in Aging Neuroscience, 14, 879021. https:\/\/doi.org\/10.3389\/fnagi.2022.879021.","journal-title":"Frontiers in Aging Neuroscience"},{"key":"1723_CR23","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.coi.2020.01.005","volume":"62","author":"L Wang","year":"2020","unstructured":"Wang, L., Negro, R., & Wu, H. (2020). TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation. Current Opinion in Immunology, 62, 131\u2013135. https:\/\/doi.org\/10.1016\/j.coi.2020.01.005.","journal-title":"Current Opinion in Immunology"},{"key":"1723_CR24","doi-asserted-by":"publisher","first-page":"116679","DOI":"10.1016\/j.biopha.2024.116679","volume":"175","author":"W Ren","year":"2024","unstructured":"Ren, W., Sun, Y., Zhao, L., & Shi, X. (2024). NLRP3 inflammasome and its role in autoimmune diseases: A promising therapeutic target. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 175, 116679. https:\/\/doi.org\/10.1016\/j.biopha.2024.116679.","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"1723_CR25","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"J Fu","year":"2023","unstructured":"Fu, J., & Wu, H. (2023). Structural mechanisms of NLRP3 inflammasome assembly and activation. Annual Review of Immunology, 41, 301\u2013316. https:\/\/doi.org\/10.1146\/annurev-immunol-081022-021207.","journal-title":"Annual Review of Immunology"},{"issue":"8","key":"1723_CR26","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson, K. V., Deng, M., & Ting, J. P. Y. (2019). The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nature Reviews Immunology, 19(8), 477\u2013489. https:\/\/doi.org\/10.1038\/s41577-019-0165-0.","journal-title":"Nature Reviews Immunology"},{"key":"1723_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2023.09.007","volume":"74","author":"T Ye","year":"2023","unstructured":"Ye, T., Tao, W., Chen, X., Jiang, C., Di, B., & Xu, L. (2023). Mechanisms of NLRP3 inflammasome activation and the development of peptide inhibitors. Cytokine & Growth Factor Reviews, 74, 1\u201313. https:\/\/doi.org\/10.1016\/j.cytogfr.2023.09.007.","journal-title":"Cytokine & Growth Factor Reviews"},{"key":"1723_CR28","doi-asserted-by":"publisher","first-page":"101394","DOI":"10.1016\/j.redox.2019.101394","volume":"29","author":"B Kalyanaraman","year":"2020","unstructured":"Kalyanaraman, B. (2020). Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree? Redox biology, 29, 101394. https:\/\/doi.org\/10.1016\/j.redox.2019.101394.","journal-title":"Redox biology"},{"key":"1723_CR29","doi-asserted-by":"publisher","first-page":"110028","DOI":"10.1016\/j.cbi.2022.110028","volume":"365","author":"N Ahmad","year":"2022","unstructured":"Ahmad, N., Ullah, A., Chu, P., Tian, W., Tang, Z., & Sun, Z. (2022). Doxorubicin induced cardio toxicity through sirtuins mediated mitochondrial disruption. Chemico-Biological Interactions, 365, 110028. https:\/\/doi.org\/10.1016\/j.cbi.2022.110028.","journal-title":"Chemico-Biological Interactions"},{"issue":"1","key":"1723_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.21037\/cdt-23-142","volume":"14","author":"H Zeng","year":"2024","unstructured":"Zeng, H., Zou, P., Chen, Y., Zhang, P., & Shao, L. (2024). NOX4 aggravates doxorubicin-induced cardiomyocyte pyroptosis by increasing reactive oxygen species content and activating the NLRP3 inflammasome. Cardiovascular Diagnosis and Therapy, 14(1), 84\u2013100. https:\/\/doi.org\/10.21037\/cdt-23-142.","journal-title":"Cardiovascular Diagnosis and Therapy"},{"key":"1723_CR31","doi-asserted-by":"publisher","first-page":"101523","DOI":"10.1016\/j.redox.2020.101523","volume":"34","author":"C Zeng","year":"2020","unstructured":"Zeng, C., Duan, F., Hu, J., Luo, B., Huang, B., Lou, X., Sun, X., Li, H., Zhang, X., Yin, S., & Tan, H. (2020). NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy. Redox Biology, 34, 101523. https:\/\/doi.org\/10.1016\/j.redox.2020.101523.","journal-title":"Redox Biology"},{"issue":"4","key":"1723_CR32","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1002\/tox.24075","volume":"39","author":"W Zhang","year":"2024","unstructured":"Zhang, W., Shi, C., Yao, Z., & Qian, S. (2024). Bardoxolone methyl attenuates doxorubicin-induced cardiotoxicity by inhibiting the TXNIP\u2013NLRP3 pathway through Nrf2 activation. Environmental Toxicology, 39(4), 1936\u20131950. https:\/\/doi.org\/10.1002\/tox.24075.","journal-title":"Environmental Toxicology"},{"issue":"1","key":"1723_CR33","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3892\/ijmm.2019.4393","volume":"45","author":"PP Huang","year":"2020","unstructured":"Huang, P. P., Fu, J., Liu, L. H., Wu, K. F., Liu, H. X., Qi, B. M., Liu, Y., & Qi, B. L. (2020). Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation. International Journal of Molecular Medicine, 45(1), 186\u2013194. https:\/\/doi.org\/10.3892\/ijmm.2019.4393.","journal-title":"International Journal of Molecular Medicine"},{"issue":"11","key":"1723_CR34","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3390\/ph14111188","volume":"14","author":"AM Kabel","year":"2021","unstructured":"Kabel, A. M., Salama, S. A., Adwas, A. A., & Estfanous, R. S. (2021). Targeting oxidative Stress, NLRP3 inflammasome, and autophagy by fraxetin to combat doxorubicin-induced cardiotoxicity. Pharmaceuticals (Basel, Switzerland), 14(11), 1188. https:\/\/doi.org\/10.3390\/ph14111188.","journal-title":"Pharmaceuticals (Basel, Switzerland)"},{"key":"1723_CR35","doi-asserted-by":"publisher","first-page":"115662","DOI":"10.1016\/j.bcp.2023.115662","volume":"214","author":"S Wei","year":"2023","unstructured":"Wei, S., Ma, W., Yang, Y., Sun, T., Jiang, C., Liu, J., Zhang, B., & Li, W. (2023). Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro. Biochemical Pharmacology, 214, 115662. https:\/\/doi.org\/10.1016\/j.bcp.2023.115662.","journal-title":"Biochemical Pharmacology"},{"issue":"1","key":"1723_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70151-w","volume":"14","author":"X Zhai","year":"2024","unstructured":"Zhai, X., Zhou, J., Huang, X., Weng, J., Lin, H., Sun, S., Chi, J., & Meng, L. (2024). LncRNA GHET1 from bone mesenchymal stem cell\u2013derived exosomes improves doxorubicin-induced pyroptosis of cardiomyocytes by mediating NLRP3. Scientific Reports, 14(1), 19078. https:\/\/doi.org\/10.1038\/s41598-024-70151-w.","journal-title":"Scientific Reports"},{"key":"1723_CR37","doi-asserted-by":"publisher","first-page":"1133354","DOI":"10.3389\/fimmu.2023.1133354","volume":"14","author":"M Pereira","year":"2023","unstructured":"Pereira, M., & Gazzinelli, R. T. (2023). Regulation of innate immune signaling by IRAK proteins. Frontiers in Immunology, 14, 1133354. https:\/\/doi.org\/10.3389\/fimmu.2023.1133354.","journal-title":"Frontiers in Immunology"},{"issue":"10","key":"1723_CR38","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s00210-021-02132-z","volume":"394","author":"F Yarmohammadi","year":"2021","unstructured":"Yarmohammadi, F., Karbasforooshan, H., Hayes, A. W., & Karimi, G. (2021). Inflammation suppression in doxorubicin-induced cardiotoxicity: Natural compounds as therapeutic options. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology, 394(10), 2003\u20132011. https:\/\/doi.org\/10.1007\/s00210-021-02132-z.","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"issue":"1","key":"1723_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01346-y","volume":"20","author":"V Quagliariello","year":"2021","unstructured":"Quagliariello, V., De Laurentiis, M., Rea, D., Barbieri, A., Monti, M. G., Carbone, A., Paccone, A., Altucci, L., Conte, M., Canale, M. L., Botti, G., & Maurea, N. (2021). The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin. Cardiovascular Diabetology, 20(1), 150. https:\/\/doi.org\/10.1186\/s12933-021-01346-y.","journal-title":"Cardiovascular Diabetology"},{"issue":"12","key":"1723_CR40","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/j.cellsig.2007.08.013","volume":"19","author":"R Ahmad","year":"2007","unstructured":"Ahmad, R., Sylvester, J., & Zafarullah, M. (2007). MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation. Cellular Signalling, 19(12), 2549\u20132557. https:\/\/doi.org\/10.1016\/j.cellsig.2007.08.013.","journal-title":"Cellular Signalling"},{"issue":"15","key":"1723_CR41","doi-asserted-by":"publisher","first-page":"3792","DOI":"10.3390\/ijms20153792","volume":"20","author":"N Lu","year":"2019","unstructured":"Lu, N., & Malemud, C. J. (2019). Extracellular signal-regulated Kinase: A regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression. International Journal of Molecular Sciences, 20(15), 3792. https:\/\/doi.org\/10.3390\/ijms20153792.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"1723_CR42","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1128\/MMBR.00043-14","volume":"80","author":"A Zeke","year":"2016","unstructured":"Zeke, A., Misheva, M., Rem\u00e9nyi, A., & Bogoyevitch, M. A. (2016). JNK signaling: Regulation and functions based on complex protein-protein partnerships. Microbiology and Molecular Biology Reviews: MMBR, 80(3), 793\u2013835. https:\/\/doi.org\/10.1128\/MMBR.00043-14.","journal-title":"Microbiology and Molecular Biology Reviews: MMBR"},{"issue":"10","key":"1723_CR43","doi-asserted-by":"publisher","first-page":"7808","DOI":"10.1074\/jbc.M108133200","volume":"277","author":"EP McDermott","year":"2002","unstructured":"McDermott, E. P., & O\u2019Neill, L. A. J. (2002). Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1*. Journal of Biological Chemistry, 277(10), 7808\u20137815. https:\/\/doi.org\/10.1074\/jbc.M108133200.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"1723_CR44","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12964-023-01077-5","volume":"21","author":"S Shi","year":"2023","unstructured":"Shi, S., Chen, Y., Luo, Z., Nie, G., & Dai, Y. (2023). Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy. Cell Communication and Signaling: CCS, 21(1), 61. https:\/\/doi.org\/10.1186\/s12964-023-01077-5.","journal-title":"Cell Communication and Signaling: CCS"},{"key":"1723_CR45","doi-asserted-by":"publisher","first-page":"115654","DOI":"10.1016\/j.biopha.2023.115654","volume":"168","author":"Z Zhong","year":"2023","unstructured":"Zhong, Z., Gao, Y., Zhou, J., Wang, F., Zhang, P., Hu, S., Wu, H., Lou, H., Chi, J., Lin, H., & Guo, H. (2023). Inhibiting mir-34a-5p regulates doxorubicin-induced autophagy disorder and alleviates myocardial pyroptosis by targeting Sirt3-AMPK pathway. Biomedicine & Pharmacotherapy, 168, 115654. https:\/\/doi.org\/10.1016\/j.biopha.2023.115654.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"5","key":"1723_CR46","doi-asserted-by":"publisher","first-page":"11087","DOI":"10.3390\/ijms160511087","volume":"16","author":"Z Wang","year":"2015","unstructured":"Wang, Z., Wang, J., Xie, R., Liu, R., & Lu, Y. (2015). Mitochondria-derived reactive oxygen species play an important role in Doxorubicin-induced platelet apoptosis. International Journal of Molecular Sciences, 16(5), 11087\u201311100. https:\/\/doi.org\/10.3390\/ijms160511087.","journal-title":"International Journal of Molecular Sciences"},{"issue":"7","key":"1723_CR47","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","volume":"55","author":"E-H Choi","year":"2023","unstructured":"Choi, E.-H., & Park, S.-J. (2023). TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target. Experimental & Molecular Medicine, 55(7), 1348\u20131356. https:\/\/doi.org\/10.1038\/s12276-023-01019-8.","journal-title":"Experimental & Molecular Medicine"},{"key":"1723_CR48","doi-asserted-by":"publisher","first-page":"514","DOI":"10.3389\/fimmu.2013.00514","volume":"4","author":"E Yoshihara","year":"2014","unstructured":"Yoshihara, E., Masaki, S., Matsuo, Y., Chen, Z., Tian, H., & Yodoi, J. (2014). Thioredoxin\/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Frontiers in Immunology, 4, 514. https:\/\/doi.org\/10.3389\/fimmu.2013.00514.","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"1723_CR49","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1159\/000485089","volume":"44","author":"L He","year":"2017","unstructured":"He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017). Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cellular Physiology and Biochemistry, 44(2), 532\u2013553. https:\/\/doi.org\/10.1159\/000485089.","journal-title":"Cellular Physiology and Biochemistry"},{"key":"1723_CR50","doi-asserted-by":"publisher","first-page":"112164","DOI":"10.1016\/j.biopha.2021.112164","volume":"143","author":"L-X Zhang","year":"2021","unstructured":"Zhang, L.-X., Li, C.-X., Kakar, M. U., Khan, M. S., Wu, P.-F., Amir, R. M., Dai, D. F., Naveed, M., Li, Q. Y., Saeed, M., Shen, J. Q., Rajput, S. A., & Li, J.-H. (2021). Resveratrol (RV): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 143, 112164. https:\/\/doi.org\/10.1016\/j.biopha.2021.112164.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"12","key":"1723_CR51","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1002\/1873-3468.14091","volume":"595","author":"ZH Maayah","year":"2021","unstructured":"Maayah, Z. H., Alam, A. S., Takahara, S., Soni, S., Ferdaoussi, M., Matsumura, N., Zordoky, B. N., Eisenstat, D. D., & Dyck, J. R. B. (2021). Resveratrol reduces cardiac NLRP3-inflammasome activation and systemic inflammation to lessen doxorubicin-induced cardiotoxicity in juvenile mice. FEBS Letters, 595(12), 1681\u20131695. https:\/\/doi.org\/10.1002\/1873-3468.14091.","journal-title":"FEBS Letters"},{"issue":"1","key":"1723_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01466-w","volume":"22","author":"J Liu","year":"2024","unstructured":"Liu, J., Zhou, J., Luan, Y., Li, X., Meng, X., Liao, W., Tang, J., & Wang, Z. (2024). cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation. Cell Communication and Signaling, 22(1), 22. https:\/\/doi.org\/10.1186\/s12964-023-01466-w.","journal-title":"Cell Communication and Signaling"},{"issue":"10","key":"1723_CR53","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/ni.3558","volume":"17","author":"Q Chen","year":"2016","unstructured":"Chen, Q., Sun, L., & Chen, Z. J. (2016). Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nature Immunology, 17(10), 1142\u20131149. https:\/\/doi.org\/10.1038\/ni.3558.","journal-title":"Nature Immunology"},{"issue":"3","key":"1723_CR54","doi-asserted-by":"publisher","first-page":"e0033621","DOI":"10.1128\/mSystems.00336-21","volume":"6","author":"NP Manes","year":"2021","unstructured":"Manes, N. P., & Nita-Lazar, A. (2021). Molecular mechanisms of the toll-like receptor, STING, MAVS, inflammasome, and interferon pathways. mSystems, 6(3), e0033621. https:\/\/doi.org\/10.1128\/mSystems.00336-21.","journal-title":"mSystems"},{"issue":"1","key":"1723_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01830-4","volume":"17","author":"Y Peng","year":"2020","unstructured":"Peng, Y., Zhuang, J., Ying, G., Zeng, H., Zhou, H., Cao, Y., Chen, H., Xu, C., Fu, X., Xu, H., Li, J., Cao, S., Chen, J., Gu, C., Yan, F., & Chen, G. (2020). Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. Journal of Neuroinflammation, 17(1), 165. https:\/\/doi.org\/10.1186\/s12974-020-01830-4.","journal-title":"Journal of Neuroinflammation"},{"key":"1723_CR56","doi-asserted-by":"publisher","first-page":"154922","DOI":"10.1016\/j.phymed.2023.154922","volume":"117","author":"G Fang","year":"2023","unstructured":"Fang, G., Li, X., Yang, F., Huang, T., Qiu, C., Peng, K., Wang, Z., Yang, Y., & Lan, C. (2023). Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING\/NLRP3 signalling pathway. Phytomedicine, 117, 154922. https:\/\/doi.org\/10.1016\/j.phymed.2023.154922.","journal-title":"Phytomedicine"},{"issue":"1","key":"1723_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11280-3","volume":"7","author":"HS Eun","year":"2017","unstructured":"Eun, H. S., Cho, S. Y., Joo, J. S., Kang, S. H., Moon, H. S., Lee, E. S., Kim, S. H., & Lee, B. S. (2017). Gene expression of NOX family members and their clinical significance in hepatocellular carcinoma. Scientific Reports, 7(1), 11060. https:\/\/doi.org\/10.1038\/s41598-017-11280-3.","journal-title":"Scientific Reports"},{"issue":"5","key":"1723_CR58","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.3892\/mmr.2020.11521","volume":"22","author":"D Cheng","year":"2020","unstructured":"Cheng, D., Chen, L., Tu, W., Wang, H., Wang, Q., Meng, L., Li, Z., & Yu, Q. (2020). Protective effects of valsartan administration on doxorubicin\u2011induced myocardial injury in rats and the role of oxidative stress and NOX2\/NOX4 signaling. Molecular Medicine Reports, 22(5), 4151\u20134162. https:\/\/doi.org\/10.3892\/mmr.2020.11521.","journal-title":"Molecular Medicine Reports"},{"key":"1723_CR59","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.2147\/JIR.S418222","volume":"16","author":"K Wang","year":"2023","unstructured":"Wang, K., Zhang, H., Yuan, L., Li, X., & Cai, Y. (2023). Potential implications of hyperoside on oxidative stress-induced human diseases: A comprehensive review. Journal of Inflammation Research, 16, 4503\u20134526. https:\/\/doi.org\/10.2147\/JIR.S418222.","journal-title":"Journal of Inflammation Research"},{"key":"1723_CR60","doi-asserted-by":"publisher","first-page":"101538","DOI":"10.1016\/j.redox.2020.101538","volume":"34","author":"Y Han","year":"2020","unstructured":"Han, Y., Sun, W., Ren, D., Zhang, J., He, Z., Fedorova, J., Sun, X., Han, F., & Li, J. (2020). SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion. Redox Biology, 34, 101538. https:\/\/doi.org\/10.1016\/j.redox.2020.101538.","journal-title":"Redox Biology"},{"key":"1723_CR61","doi-asserted-by":"publisher","first-page":"9952578","DOI":"10.1155\/2021\/9952578","volume":"2021","author":"G Gong","year":"2021","unstructured":"Gong, G., Zheng, Y., Yang, Y., Sui, Y., & Wen, Z. (2021). Pharmaceutical values of Calycosin: one type of flavonoid isolated from Astragalus. Evidence-Based Complementary and Alternative Medicine: eCAM, 2021, 9952578. https:\/\/doi.org\/10.1155\/2021\/9952578.","journal-title":"Evidence-Based Complementary and Alternative Medicine: eCAM"},{"issue":"3","key":"1723_CR62","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/ptr.6557","volume":"34","author":"J Zhai","year":"2020","unstructured":"Zhai, J., Tao, L., Zhang, S., Gao, H., Zhang, Y., Sun, J., Song, Y., & Qu, X. (2020). Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway. Phytotherapy Research: PTR, 34(3), 649\u2013659. https:\/\/doi.org\/10.1002\/ptr.6557.","journal-title":"Phytotherapy Research: PTR"},{"key":"1723_CR63","doi-asserted-by":"publisher","first-page":"1733834","DOI":"10.1155\/2022\/1733834","volume":"2022","author":"L Zhang","year":"2022","unstructured":"Zhang, L., Fan, C., Jiao, H.-C., Zhang, Q., Jiang, Y.-H., Cui, J., Liu, Y., Jiang, Y. H., Zhang, J., Yang, M. Q., Li, Y., & Xue, Y.-T. (2022). Calycosin alleviates doxorubicin-induced cardiotoxicity and pyroptosis by inhibiting NLRP3 inflammasome activation. Oxidative Medicine and Cellular Longevity, 2022, 1733834. https:\/\/doi.org\/10.1155\/2022\/1733834.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"1723_CR64","doi-asserted-by":"publisher","first-page":"113888","DOI":"10.1016\/j.bcp.2020.113888","volume":"175","author":"Z Sun","year":"2020","unstructured":"Sun, Z., Lu, W., Lin, N., Lin, H., Zhang, J., Ni, T., Meng, L., Zhang, C., & Guo, H. (2020). Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1. Biochemical Pharmacology, 175, 113888. https:\/\/doi.org\/10.1016\/j.bcp.2020.113888.","journal-title":"Biochemical Pharmacology"},{"issue":"2","key":"1723_CR65","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1142\/S0192415X24500198","volume":"52","author":"W Tian","year":"2024","unstructured":"Tian, W., Zhang, P., Yang, L., Song, P., Zhao, J., Wang, H., Zhao, Y., & Cao, L. (2024). Astragaloside IV alleviates doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte pyroptosis through the SIRT1\/NLRP3 pathway. American Journal of Chinese Medicine, 52(2), 453\u2013469. https:\/\/doi.org\/10.1142\/S0192415X24500198.","journal-title":"American Journal of Chinese Medicine"},{"issue":"13","key":"1723_CR66","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.3390\/ijms21134777","volume":"21","author":"F He","year":"2020","unstructured":"He, F., Ru, X., & Wen, T. (2020). NRF2, a transcription factor for stress response and beyond. International Journal of Molecular Sciences, 21(13), 4777. https:\/\/doi.org\/10.3390\/ijms21134777.","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"1723_CR67","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1089\/ars.2015.6615","volume":"26","author":"X Liu","year":"2017","unstructured":"Liu, X., Zhang, X., Ding, Y., Zhou, W., Tao, L., Lu, P., Wang, Y., & Hu, R. (2017). Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming. Antioxidants & Redox Signaling, 26(1), 28\u201343. https:\/\/doi.org\/10.1089\/ars.2015.6615.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"1","key":"1723_CR68","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01565-0","volume":"9","author":"X Zhao","year":"2023","unstructured":"Zhao, X., Tian, Z., Sun, M., & Dong, D. (2023). Nrf2: a dark horse in doxorubicin-induced cardiotoxicity. Cell Death Discovery, 9(1), 261. https:\/\/doi.org\/10.1038\/s41420-023-01565-0.","journal-title":"Cell Death Discovery"},{"issue":"18","key":"1723_CR69","doi-asserted-by":"publisher","first-page":"14013","DOI":"10.3390\/ijms241814013","volume":"24","author":"MF Nagoor Meeran","year":"2023","unstructured":"Nagoor Meeran, M. F., Arunachalam, S., Azimullah, S., Saraswathiamma, D., Albawardi, A., Almarzooqi, S., Jha, N. K., Subramanya, S., Beiram, R., & Ojha, S. (2023). \u03b1-Bisabolol, a dietary sesquiterpene, attenuates doxorubicin-induced acute cardiotoxicity in rats by inhibiting cellular signaling pathways, Nrf2\/Keap-1\/HO-1, Akt\/mTOR\/GSK-3\u03b2, NF-\u03baB\/p38\/MAPK, and NLRP3 inflammasomes regulating oxidative stress and inflamm. International Journal of Molecular Sciences, 24(18), 14013. https:\/\/doi.org\/10.3390\/ijms241814013.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"1723_CR70","doi-asserted-by":"publisher","first-page":"45","DOI":"10.31083\/j.fbl2803045","volume":"28","author":"X Chen","year":"2023","unstructured":"Chen, X., Tian, C., Zhang, Z., Qin, Y., Meng, R., Dai, X., Zhong, Y., Wei, X., Zhang, J., & Shen, C. (2023). Astragaloside IV inhibits NLRP3 inflammasome-mediated pyroptosis via activation of Nrf-2\/HO-1 signaling pathway and protects against doxorubicin-induced cardiac dysfunction. Frontiers in Bioscience - Landmark, 28(3), 45. https:\/\/doi.org\/10.31083\/j.fbl2803045.","journal-title":"Frontiers in Bioscience - Landmark"},{"key":"1723_CR71","doi-asserted-by":"publisher","first-page":"107533","DOI":"10.1016\/j.intimp.2021.107533","volume":"95","author":"J Gu","year":"2021","unstructured":"Gu, J., Huang, H., Liu, C., Jiang, B., Li, M., Liu, L., & Zhang, S. (2021). Pinocembrin inhibited cardiomyocyte pyroptosis against doxorubicin-induced cardiac dysfunction via regulating Nrf2\/Sirt3 signaling pathway. International Immunopharmacology, 95, 107533. https:\/\/doi.org\/10.1016\/j.intimp.2021.107533.","journal-title":"International Immunopharmacology"},{"issue":"2","key":"1723_CR72","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1042\/BJ20140306","volume":"463","author":"Y-J Son","year":"2014","unstructured":"Son, Y.-J., Kwon, M., Ro, D.-K., & Kim, S.-U. (2014). Enantioselective microbial synthesis of the indigenous natural product (-)-\u03b1-bisabolol by a sesquiterpene synthase from chamomile (Matricaria recutita). The Biochemical Journal, 463(2), 239\u2013248. https:\/\/doi.org\/10.1042\/BJ20140306.","journal-title":"The Biochemical Journal"},{"key":"1723_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11746-009-1483-3","volume":"87","author":"GP Kamatou","year":"2009","unstructured":"Kamatou, G. P., & Viljoen, A. (2009). A review of the application and pharmacological properties of \u03b1-bisabolol and \u03b1-bisabolol-rich oils. J. Am. Oil Chem. Soc., 87, 1\u20137. https:\/\/doi.org\/10.1007\/s11746-009-1483-3.","journal-title":"J. Am. Oil Chem. Soc."},{"issue":"1","key":"1723_CR74","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12942","volume":"7","author":"U Scheler","year":"2016","unstructured":"Scheler, U., Brandt, W., Porzel, A., Rothe, K., Manzano, D., Bo\u017ei\u0107, D., Papaefthimiou, D., Balcke, G. U., Henning, A., Lohse, S., Marillonnet, S., Kanellis, A. K., Ferrer, A., & Tissier, A. (2016). Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast. Nature Communications, 7(1), 12942. https:\/\/doi.org\/10.1038\/ncomms12942.","journal-title":"Nature Communications"},{"key":"1723_CR75","doi-asserted-by":"publisher","first-page":"114337","DOI":"10.1016\/j.biopha.2023.114337","volume":"161","author":"A Bouyahya","year":"2023","unstructured":"Bouyahya, A., Taha, D., Benali, T., Zengin, G., El Omari, N., El Hachlafi, N., Khalid, A., Abdalla, A. N., Ardianto, C., Tan, C. S., Ming, L. C., & Sahib, N. (2023). Natural sources, biological effects, and pharmacological properties of cynaroside. Biomedicine & Pharmacotherapy, 161, 114337. https:\/\/doi.org\/10.1016\/j.biopha.2023.114337.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"7","key":"1723_CR76","doi-asserted-by":"publisher","first-page":"2400092","DOI":"10.1002\/ardp.202400092","volume":"357","author":"NM Ha","year":"2024","unstructured":"Ha, N. M., & Son, N. T. (2024). Health benefits of fraxetin: From chemistry to medicine. Archiv der Pharmazie, 357(7), 2400092. https:\/\/doi.org\/10.1002\/ardp.202400092.","journal-title":"Archiv der Pharmazie"},{"issue":"1","key":"1723_CR77","doi-asserted-by":"publisher","first-page":"379850","DOI":"10.1155\/2013\/379850","volume":"2013","author":"A Rasul","year":"2013","unstructured":"Rasul, A., Millimouno, F. M., Ali Eltayb, W., Ali, M., Li, J., & Li, X. (2013). Pinocembrin: A novel natural compound with versatile pharmacological and biological activities. BioMed Research International, 2013(1), 379850. https:\/\/doi.org\/10.1155\/2013\/379850.","journal-title":"BioMed Research International"},{"issue":"14","key":"1723_CR78","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1128\/MCB.00118-16","volume":"36","author":"MS Joo","year":"2016","unstructured":"Joo, M. S., Kim, W. D., Lee, K. Y., Kim, J. H., Koo, J. H., & Kim, S. G. (2016). AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550. Molecular and Cellular Biology, 36(14), 1931\u20131942.","journal-title":"Molecular and Cellular Biology"},{"key":"1723_CR79","doi-asserted-by":"publisher","first-page":"632606","DOI":"10.3389\/fimmu.2021.632606","volume":"12","author":"F Yang","year":"2021","unstructured":"Yang, F., Ye, X.-J., Chen, M.-Y., Li, H.-C., Wang, Y.-F., Zhong, M.-Y., Zhong, C. S., Zeng, B., Xu, L. H., He, X. H., & Ouyang, D.-Y. (2021). Inhibition of NLRP3 inflammasome activation and pyroptosis in macrophages by taraxasterol is associated with its regulation on mTOR signaling. Frontiers in Immunology, 12, 632606. https:\/\/doi.org\/10.3389\/fimmu.2021.632606.","journal-title":"Frontiers in Immunology"},{"key":"1723_CR80","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s00210-021-02072-8","volume":"394","author":"F Yarmohammadi","year":"2021","unstructured":"Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2021). Protective effects of curcumin on chemical and drug-induced cardiotoxicity: A review. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology, 394, 1341\u20131353. https:\/\/doi.org\/10.1007\/s00210-021-02072-8.","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"key":"1723_CR81","doi-asserted-by":"publisher","first-page":"1292022","DOI":"10.3389\/fimmu.2023.1292022","volume":"14","author":"L Yan","year":"2023","unstructured":"Yan, L., Cui, Y., & Feng, J. (2023). Biology of Pellino1: a potential therapeutic target for inflammation in diseases and cancers. Frontiers in Immunology, 14, 1292022. https:\/\/doi.org\/10.3389\/fimmu.2023.1292022.","journal-title":"Frontiers in Immunology"},{"key":"1723_CR82","doi-asserted-by":"publisher","first-page":"121334","DOI":"10.1016\/j.carbpol.2023.121334","volume":"321","author":"E Zhang","year":"2023","unstructured":"Zhang, E., Shang, C., Ma, M., Zhang, X., Liu, Y., Song, S., & Li, X. (2023). Polyguluronic acid alleviates doxorubicin-induced cardiotoxicity by suppressing Peli1-NLRP3 inflammasome-mediated pyroptosis. Carbohydrate Polymers, 321, 121334. https:\/\/doi.org\/10.1016\/j.carbpol.2023.121334.","journal-title":"Carbohydrate Polymers"},{"key":"1723_CR83","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.ijbiomac.2018.06.154","volume":"118","author":"RA Khajouei","year":"2018","unstructured":"Khajouei, R. A., Keramat, J., Hamdami, N., Ursu, A.-V., Delattre, C., Laroche, C., Gardarin, C., Lecerf, D., Desbri\u00e8res, J., Djelveh, G., & Michaud, P. (2018). Extraction and characterization of an alginate from the Iranian brown seaweed Nizimuddinia zanardini. International Journal of Biological Macromolecules, 118, 1073\u20131081. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.06.154.","journal-title":"International Journal of Biological Macromolecules"},{"issue":"1","key":"1723_CR84","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/bab.1700","volume":"66","author":"T Sho","year":"2019","unstructured":"Sho, T., & Xu, J. (2019). Role and mechanism of ROS scavengers in alleviating NLRP3\u2010mediated inflammation. Biotechnology and Applied Biochemistry, 66(1), 4\u201313.","journal-title":"Biotechnology and Applied Biochemistry"},{"issue":"6","key":"1723_CR85","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3177\/jnsv.65.470","volume":"65","author":"L Wang","year":"2019","unstructured":"Wang, L., Wu, H., Yang, F., & Dong, W. (2019). The protective effects of myricetin against cardiovascular disease. Journal of Nutritional Science and Vitaminology, 65(6), 470\u2013476. https:\/\/doi.org\/10.3177\/jnsv.65.470.","journal-title":"Journal of Nutritional Science and Vitaminology"},{"issue":"2","key":"1723_CR86","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/nu13020342","volume":"13","author":"R Pluta","year":"2021","unstructured":"Pluta, R., Januszewski, S., & Czuczwar, S. J. (2021). Myricetin as a promising molecule for the treatment of post-ischemic brain neurodegeneration. Nutrients, 13(2), 342. https:\/\/doi.org\/10.3390\/nu13020342.","journal-title":"Nutrients"},{"key":"1723_CR87","doi-asserted-by":"publisher","first-page":"109506","DOI":"10.1016\/j.biopha.2019.109506","volume":"120","author":"M Jiang","year":"2019","unstructured":"Jiang, M., Zhu, M., Wang, L., & Yu, S. (2019). Anti-tumor effects and associated molecular mechanisms of myricetin. Biomedicine & Pharmacotherapy, 120, 109506. https:\/\/doi.org\/10.1016\/j.biopha.2019.109506.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1723_CR88","doi-asserted-by":"publisher","first-page":"116748","DOI":"10.1016\/j.biopha.2024.116748","volume":"175","author":"J Li","year":"2024","unstructured":"Li, J., Luo, T., Zhao, Y., Wang, D., Jin, Y., Wu, Z., Yang, G., & Qi, X. (2024). Cardioprotective potentials of myricetin on doxorubicin-induced cardiotoxicity based on biochemical and transcriptomic analysis. Biomedicine and Pharmacotherapy, 175, 116748. https:\/\/doi.org\/10.1016\/j.biopha.2024.116748.","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"5","key":"1723_CR89","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3390\/molecules21050529","volume":"21","author":"W-K Chan","year":"2016","unstructured":"Chan, W.-K., Tan, L. T.-H., Chan, K.-G., Lee, L.-H., & Goh, B.-H. (2016). Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules, 21(5), 529. https:\/\/doi.org\/10.3390\/molecules21050529.","journal-title":"Molecules"},{"issue":"26","key":"1723_CR90","doi-asserted-by":"publisher","first-page":"7334","DOI":"10.1021\/acs.jafc.0c05667","volume":"69","author":"MFN Meeran","year":"2021","unstructured":"Meeran, M. F. N., Azimullah, S., Mamoudh, H. H., Sharma, C., Kumar, S., Goyal, S. N., & Ojha, S. (2021). Nerolidol, a sesquiterpene from the essential oils of aromatic plants, attenuates doxorubicin-induced chronic cardiotoxicity in rats. Journal of Agricultural and Food Chemistry, 69(26), 7334\u20137343. https:\/\/doi.org\/10.1021\/acs.jafc.0c05667.","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"12","key":"1723_CR91","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.3390\/molecules25122791","volume":"25","author":"B Zheng","year":"2020","unstructured":"Zheng, B., & McClements, D. J. (2020). Formulation of more efficacious curcumin delivery systems using colloid science: enhanced solubility, stability, and bioavailability. Molecules, 25(12), 2791. https:\/\/doi.org\/10.3390\/molecules25122791.","journal-title":"Molecules"},{"issue":"2","key":"1723_CR92","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.ijpharm.2015.01.003","volume":"479","author":"N Summerlin","year":"2015","unstructured":"Summerlin, N., Soo, E., Thakur, S., Qu, Z., Jambhrunkar, S., & Popat, A. (2015). Resveratrol nanoformulations: challenges and opportunities. International Journal of Pharmaceutics, 479(2), 282\u2013290. https:\/\/doi.org\/10.1016\/j.ijpharm.2015.01.003.","journal-title":"International Journal of Pharmaceutics"},{"issue":"6","key":"1723_CR93","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1742-7843.2004.t01-1-pto950508.x","volume":"95","author":"Y Gu","year":"2004","unstructured":"Gu, Y., Wang, G., Pan, G., Fawcett, J. P., A, J., & Sun, J. (2004). Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix Astragali. Basic & Clinical Pharmacology & Toxicology, 95(6), 295\u2013298. https:\/\/doi.org\/10.1111\/j.1742-7843.2004.t01-1-pto950508.x.","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"issue":"9","key":"1723_CR94","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/bdd.2304","volume":"42","author":"H Qiu","year":"2021","unstructured":"Qiu, H., Guo, Z., Xu, Q., Mao, S., & Wu, W. (2021). Evaluation on absorption risks of amentoflavone after oral administration in rats. Biopharmaceutics & Drug Disposition, 42(9), 435\u2013443. https:\/\/doi.org\/10.1002\/bdd.2304.","journal-title":"Biopharmaceutics & Drug Disposition"},{"key":"1723_CR95","doi-asserted-by":"publisher","first-page":"107287","DOI":"10.1016\/j.biotechadv.2018.08.004","volume":"38","author":"DJ McClements","year":"2020","unstructured":"McClements, D. J. (2020). Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals. Biotechnology Advances, 38, 107287. https:\/\/doi.org\/10.1016\/j.biotechadv.2018.08.004.","journal-title":"Biotechnology Advances"},{"issue":"24","key":"1723_CR96","doi-asserted-by":"publisher","first-page":"13567","DOI":"10.3390\/ijms252413567","volume":"25","author":"J Szponar","year":"2024","unstructured":"Szponar, J., Ciechanski, E., Ciechanska, M., Dudka, J., & Mandziuk, S. (2024). Evolution of theories on doxorubicin-induced late cardiotoxicity-role of topoisomerase. International Journal of Molecular Sciences, 25(24), 13567. https:\/\/doi.org\/10.3390\/ijms252413567.","journal-title":"International Journal of Molecular Sciences"},{"key":"1723_CR97","doi-asserted-by":"publisher","unstructured":"Liu, S., Liu, J., Su, N., Wei, S., Xie, N., Li, X., Xie S., Liu J., Zhang B., Li W., Tan, S. (2024). An integrated network pharmacology and RNA-seq approach for exploring the protective effect of andrographolide in doxorubicin-induced cardiotoxicity. Cardiovascular Drugs and Therapy. https:\/\/doi.org\/10.1007\/s10557-024-07555-3","DOI":"10.1007\/s10557-024-07555-3"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01723-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01723-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01723-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T08:22:20Z","timestamp":1757146940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01723-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":97,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["1723"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01723-4","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"8 March 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}