{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T05:21:51Z","timestamp":1764912111264,"version":"3.46.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Young Talents of Basic Research in Universities of Heilongjiang Province","award":["YQJH2023047"],"award-info":[{"award-number":["YQJH2023047"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01786-3","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T06:15:52Z","timestamp":1748672152000},"page":"4567-4581","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lysine Demethylase 5B Alleviates Neuroinflammation in Ischemic Stroke by Repressing Steap4"],"prefix":"10.1007","volume":"83","author":[{"given":"Qi","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"issue":"10244","key":"1786_CR1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","volume":"396","author":"BCV Campbell","year":"2020","unstructured":"Campbell, B. C. V., & Khatri, P. (2020). Stroke. Lancet, 396(10244), 129\u2013142.","journal-title":"Lancet"},{"issue":"4","key":"1786_CR2","doi-asserted-by":"publisher","first-page":"165260","DOI":"10.1016\/j.bbadis.2018.09.012","volume":"1866","author":"D Barthels","year":"2020","unstructured":"Barthels, D., & Das, H. (2020). Current advances in ischemic stroke research and therapies. Biochimica et Biophysica Acta-Molecular Basis of Diseas, 1866(4), 165260.","journal-title":"Biochimica et Biophysica Acta-Molecular Basis of Diseas"},{"issue":"3","key":"1786_CR3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/17474930231210448","volume":"19","author":"J Kim","year":"2024","unstructured":"Kim, J., Olaiya, M. T., De Silva, D. A., Norrving, B., Bosch, J., De Sousa, D. A., Christensen, H. K., Ranta, A., Donnan, G. A., Feigin, V., Martins, S., Schwamm, L. H., Werring, D. J., Howard, G., Owolabi, M., Pandian, J., Mikulik, R., Thayabaranathan, T., & Cadilhac, D. A. (2024). Global stroke statistics 2023: Availability of reperfusion services around the world. International Journal of Stroke, 19(3), 253\u2013270.","journal-title":"International Journal of Stroke"},{"issue":"3","key":"1786_CR4","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1161\/STROKEAHA.122.038466","volume":"54","author":"X Nie","year":"2023","unstructured":"Nie, X., Leng, X., Miao, Z., Fisher, M., & Liu, L. (2023). Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke. Stroke, 54(3), 873\u2013881.","journal-title":"Stroke"},{"issue":"45","key":"1786_CR5","doi-asserted-by":"publisher","first-page":"7463","DOI":"10.1523\/JNEUROSCI.1376-23.2023","volume":"43","author":"D Barnett","year":"2023","unstructured":"Barnett, D., Bohmbach, K., Grelot, V., Charlet, A., Dall\u00e9rac, G., Ju, Y. H., Nagai, J., & Orr, A. G. (2023). Astrocytes as drivers and disruptors of behavior: New advances in basic mechanisms and therapeutic targeting. The Journal of Neuroscience, 43(45), 7463\u20137471.","journal-title":"The Journal of Neuroscience"},{"key":"1786_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pneurobio.2015.09.008","volume":"144","author":"Z Liu","year":"2016","unstructured":"Liu, Z., & Chopp, M. (2016). Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke. Progress in Neurobiology, 144, 103\u2013120.","journal-title":"Progress in Neurobiology"},{"issue":"4","key":"1786_CR7","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","volume":"94","author":"M Pekny","year":"2014","unstructured":"Pekny, M., & Pekna, M. (2014). Astrocyte reactivity and reactive astrogliosis: costs and benefits. Physiological Reviews, 94(4), 1077\u20131098.","journal-title":"Physiological Reviews"},{"issue":"7638","key":"1786_CR8","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"SA Liddelow","year":"2017","unstructured":"Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., M\u00fcnch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V. L., Dawson, T. M., & Stevens, B. (2017). Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 541(7638), 481\u2013487.","journal-title":"Nature"},{"key":"1786_CR9","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fimmu.2020.00294","volume":"11","author":"S Xu","year":"2020","unstructured":"Xu, S., Lu, J., Shao, A., Zhang, J. H., & Zhang, J. (2020). Glial cells: Role of the immune response in ischemic stroke. Frontiers in Immunology, 11, 294.","journal-title":"Frontiers in Immunology"},{"key":"1786_CR10","doi-asserted-by":"publisher","first-page":"106885","DOI":"10.1016\/j.nbd.2025.106885","volume":"209","author":"D Li","year":"2025","unstructured":"Li, D., Huo, X., Shen, L., Qian, M., Wang, J., Mao, S., Chen, W., Li, R., Zhu, T., Zhang, B., Liu, K., Wu, F., & Bai, Y. (2025). Astrocyte heterogeneity in ischemic stroke: Molecular mechanisms and therapeutic targets. Neurobiology of Disease, 209, 106885.","journal-title":"Neurobiology of Disease"},{"issue":"3","key":"1786_CR11","doi-asserted-by":"publisher","first-page":"R123","DOI":"10.1530\/JOE-16-0594","volume":"234","author":"RT Scarl","year":"2017","unstructured":"Scarl, R. T., Lawrence, C. M., Gordon, H. M., & Nunemaker, C. S. (2017). STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper. The Journal of Endocrinology, 234(3), R123\u2013R134.","journal-title":"The Journal of Endocrinology"},{"key":"1786_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.semcancer.2018.11.001","volume":"57","author":"B Xhabija","year":"2019","unstructured":"Xhabija, B., & Kidder, B. L. (2019). KDM5B is a master regulator of the H3K4-methylome in stem cells, development, and cancer. Seminars in Cancer Biology, 57, 79\u201385.","journal-title":"Seminars in Cancer Biology"},{"issue":"1","key":"1786_CR13","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bbadis.2016.09.014","volume":"1863","author":"S Chakravarty","year":"2017","unstructured":"Chakravarty, S., Jhelum, P., Bhat, U. A., Rajan, W. D., Maitra, S., Pathak, S. S., Patel, A. B., & Kumar, A. (2017). Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. Biochimica et Biophysica Acta-Molecular Basis of Diseas, 1863(1), 152\u2013164.","journal-title":"Biochimica et Biophysica Acta-Molecular Basis of Diseas"},{"key":"1786_CR14","doi-asserted-by":"publisher","first-page":"714943","DOI":"10.3389\/fimmu.2021.714943","volume":"12","author":"H Zhu","year":"2021","unstructured":"Zhu, H., Jian, Z., Zhong, Y., Ye, Y., Zhang, Y., Hu, X., Pu, B., Gu, L., & Xiong, X. (2021). Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition. Frontiers in Immunology, 12, 714943.","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"1786_CR15","doi-asserted-by":"publisher","first-page":"e14707","DOI":"10.1111\/cns.14707","volume":"30","author":"M Li","year":"2024","unstructured":"Li, M., Zhang, Y., Yu, G., Gu, L., Zhu, H., Feng, S., Xiong, X., & Jian, Z. (2024). Mitochondria-associated endoplasmic reticulum membranes tethering protein VAPB-PTPIP51 protects against ischemic stroke through inhibiting the activation of autophagy. CNS Neuroscience & Therapeutics, 30(4), e14707.","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"1","key":"1786_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0527-5","volume":"13","author":"YF Dong","year":"2016","unstructured":"Dong, Y. F., Chen, Z. Z., Zhao, Z., Yang, D. D., Yan, H., Ji, J., & Sun, X. L. (2016). Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation. Journal of Neuroinflammation, 13(1), 60.","journal-title":"Journal of Neuroinflammation"},{"issue":"5","key":"1786_CR17","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.ajpath.2013.01.034","volume":"182","author":"MA Kuszczyk","year":"2013","unstructured":"Kuszczyk, M. A., Sanchez, S., Pankiewicz, J., Kim, J., Duszczyk, M., Guridi, M., Asuni, A. A., Sullivan, P. M., Holtzman, D. M., & Sadowski, M. J. (2013). Blocking the interaction between apolipoprotein E and Abeta reduces intraneuronal accumulation of Abeta and inhibits synaptic degeneration. The American Journal of Pathology, 182(5), 1750\u20131768.","journal-title":"The American Journal of Pathology"},{"issue":"1","key":"1786_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02119-w","volume":"18","author":"G Singh","year":"2021","unstructured":"Singh, G., Segura, B. J., Georgieff, M. K., & Gisslen, T. (2021). Fetal inflammation induces acute immune tolerance in the neonatal rat hippocampus. Journal of Neuroinflammation, 18(1), 69.","journal-title":"Journal of Neuroinflammation"},{"key":"1786_CR19","doi-asserted-by":"publisher","first-page":"106044","DOI":"10.1016\/j.nbd.2023.106044","volume":"179","author":"RY Zhao","year":"2023","unstructured":"Zhao, R. Y., Wei, P. J., Sun, X., Zhang, D. H., He, Q. Y., Liu, J., Chang, J. L., Yang, Y., & Guo, Z. N. (2023). Role of lipocalin 2 in stroke. Neurobiology of Disease, 179, 106044.","journal-title":"Neurobiology of Disease"},{"issue":"2","key":"1786_CR20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.gpb.2019.09.006","volume":"18","author":"Q Zhang","year":"2020","unstructured":"Zhang, Q., Liu, W., Zhang, H. M., Xie, G. Y., Miao, Y. R., Xia, M., & Guo, A. Y. (2020). hTFtarget: A comprehensive database for regulations of human transcription factors and their targets. Genomics, Proteomics & Bioinformatics \/ Beijing Genomics Institute, 18(2), 120\u2013128.","journal-title":"Genomics, Proteomics & Bioinformatics \/ Beijing Genomics Institute"},{"issue":"D1","key":"1786_CR21","doi-asserted-by":"publisher","first-page":"D1243","DOI":"10.1093\/nar\/gkae974","volume":"53","author":"G Perez","year":"2025","unstructured":"Perez, G., Barber, G. P., Benet-Pages, A., Casper, J., Clawson, H., Diekhans, M., Fischer, C., Gonzalez, J. N., Hinrichs, A. S., Lee, C. M., Nassar, L. R., Raney, B. J., Speir, M. L., van Baren, M. J., Vaske, C. J., Haussler, D., Kent, W. J., & Haeussler, M. (2025). The UCSC genome browser database: 2025 update. Nucleic Acids Research, 53(D1), D1243\u2013D1249.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"1786_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1177\/0271678X211026770","volume":"42","author":"K Zheng","year":"2022","unstructured":"Zheng, K., Lin, L., Jiang, W., Chen, L., Zhang, X., Zhang, Q., Ren, Y., & Hao, J. (2022). Single-cell RNA-seq reveals the transcriptional landscape in ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 42(1), 56\u201373.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"1786_CR23","doi-asserted-by":"publisher","first-page":"828447","DOI":"10.3389\/fimmu.2022.828447","volume":"13","author":"H Zhu","year":"2022","unstructured":"Zhu, H., Hu, S., Li, Y., Sun, Y., Xiong, X., Hu, X., Chen, J., & Qiu, S. (2022). Interleukins and ischemic stroke. Frontiers in Immunology, 13, 828447.","journal-title":"Frontiers in Immunology"},{"issue":"Pt 1","key":"1786_CR24","doi-asserted-by":"publisher","first-page":"142797","DOI":"10.1016\/j.ijbiomac.2025.142797","volume":"309","author":"Q Cai","year":"2025","unstructured":"Cai, Q., Jing, C., Wang, X., Xing, X., & Liu, W. (2025). STEAP proteins: Roles in disease biology and potential for therapeutic intervention. International Journal of Biological Macromolecules, 309(Pt 1), 142797.","journal-title":"International Journal of Biological Macromolecules"},{"issue":"20","key":"1786_CR25","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.21037\/atm-21-2794","volume":"9","author":"H Jiang","year":"2021","unstructured":"Jiang, H., Dong, Y., Yan, D., Wu, Y., Wang, Y., Ren, Y., Mao, G., Liang, G., Liu, W., Zhou, Y., Huang, Z., & Qi, L. (2021). The expression of STEAP4 in peripheral blood predicts the outcome of septic patients. Annals of Translational Medicine, 9(20), 1519.","journal-title":"Annals of Translational Medicine"},{"issue":"45","key":"1786_CR26","first-page":"E9608","volume":"114","author":"X Xue","year":"2017","unstructured":"Xue, X., Bredell, B. X., Anderson, E. R., Martin, A., Mays, C., Nagao-Kitamoto, H., Huang, S., Gy\u0151rffy, B., Greenson, J. K., Hardiman, K., Spence, J. R., Kamada, N., & Shah, Y. M. (2017). Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proceedings of the National Academy of Sciences of the United States of America, 114(45), E9608\u2013E9617.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"1786_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02146-7","volume":"18","author":"J Zhao","year":"2021","unstructured":"Zhao, J., Liao, Y., Miller-Little, W., Xiao, J., Liu, C., Li, X., Li, X., & Kang, Z. (2021). STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis. Journal of Neuroinflammation, 18(1), 98.","journal-title":"Journal of Neuroinflammation"},{"key":"1786_CR28","doi-asserted-by":"publisher","first-page":"149550","DOI":"10.1016\/j.bbrc.2024.149550","volume":"701","author":"R Gao","year":"2024","unstructured":"Gao, R., Ali, T., Liu, Z., Li, A., Hao, L., He, L., Yu, X., & Li, S. (2024). Ceftriaxone averts neuroinflammation and relieves depressive-like behaviors via GLT-1\/TrkB signaling. Biochemical and Biophysical Research Communications, 701, 149550.","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"1","key":"1786_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14698-y","volume":"11","author":"Y Liao","year":"2020","unstructured":"Liao, Y., Zhao, J., Bulek, K., Tang, F., Chen, X., Cai, G., Jia, S., Fox, P. L., Huang, E., Pizarro, T. T., Kalady, M. F., Jackson, M. W., Bao, S., Sen, G. C., Stark, G. R., Chang, C. J., & Li, X. (2020). Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nature Communications, 11(1), 900.","journal-title":"Nature Communications"},{"issue":"1-2","key":"1786_CR30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","volume":"168","author":"Q Zhang","year":"2017","unstructured":"Zhang, Q., Lenardo, M. J., & Baltimore, D. (2017). 30 years of NF-kappaB: A blossoming of relevance to human pathobiology. Cell, 168(1-2), 37\u201357.","journal-title":"Cell"},{"issue":"6","key":"1786_CR31","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow, S. A., & Barres, B. A. (2017). Reactive astrocytes: Production, function, and therapeutic potential. Immunity, 46(6), 957\u2013967.","journal-title":"Immunity"},{"issue":"22","key":"1786_CR32","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1038\/emboj.2011.383","volume":"30","author":"SU Schmitz","year":"2011","unstructured":"Schmitz, S. U., Albert, M., Malatesta, M., Morey, L., Johansen, J. V., Bak, M., Tommerup, N., Abarrategui, I., & Helin, K. (2011). Jarid1b targets genes regulating development and is involved in neural differentiation. The EMBO Journal, 30(22), 4586\u20134600.","journal-title":"The EMBO Journal"},{"issue":"4","key":"1786_CR33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1177\/0271678X231216158","volume":"44","author":"J Huang","year":"2024","unstructured":"Huang, J., Wang, X. S., Gao, T., Wang, X., Yu, M. Y., Song, H. X., Wang, B. Y., Li, L. M., Zeng, Q., & Zhang, H. N. (2024). Astrocyte KDM4A mediates chemokines and drives neutrophil infiltration to aggravate cerebral ischemia and reperfusion injury. Journal of Cerebral Blood Flow and Metabolism, 44(4), 491\u2013507.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"1786_CR34","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1073\/pnas.1914742117","volume":"117","author":"A Al Mamun","year":"2020","unstructured":"Al Mamun, A., Chauhan, A., Qi, S., Ngwa, C., Xu, Y., Sharmeen, R., Hazen, A. L., Li, J., Aronowski, J. A., McCullough, L. D., & Liu, F. (2020). Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes. Proceedings of the National Academy of Sciences of the United States of America, 117(3), 1742\u20131752.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"1786_CR35","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/s41419-019-1558-5","volume":"10","author":"J Li","year":"2019","unstructured":"Li, J., Zhang, J., Zhang, Y., Wang, Z., Song, Y., Wei, S., He, M., You, S., Jia, J., & Cheng, J. (2019). TRAF2 protects against cerebral ischemia-induced brain injury by suppressing necroptosis. Cell Death & Disease, 10(5), 328.","journal-title":"Cell Death & Disease"},{"issue":"2","key":"1786_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S1084-9521(02)00018-6","volume":"13","author":"Z Zhu","year":"2002","unstructured":"Zhu, Z., Zheng, T., Lee, C. G., Homer, R. J., & Elias, J. A. (2002). Tetracycline-controlled transcriptional regulation systems: advances and application in transgenic animal modeling. Seminars in Cell & Developmental Biology, 13(2), 121\u2013128.","journal-title":"Seminars in Cell & Developmental Biology"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01786-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01786-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01786-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T04:52:01Z","timestamp":1764910321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01786-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1786"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01786-3","relation":{},"ISSN":["1559-0283"],"issn-type":[{"type":"electronic","value":"1559-0283"}],"subject":[],"published":{"date-parts":[[2025,5,31]]},"assertion":[{"value":"17 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The Animal Ethics Committee of Harbin Medical University Affiliated Fourth Hospital approved the use of animals. All animal experiments were conducted following the Guide for the Care and Use of Laboratory Animals (NIH, Bethesda, MD, USA).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}