{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:56:21Z","timestamp":1786982181531,"version":"build-2736575974"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shanghai Municipal Education Commission Professional Master's Degree Excellent Cultivation Research Project","award":["No. 2023PYZX20"],"award-info":[{"award-number":["No. 2023PYZX20"]}]},{"name":"2022 Research Project of Shanghai Sanda University","award":["No. 2022BSZX04"],"award-info":[{"award-number":["No. 2022BSZX04"]}]},{"name":"the 2025 Key Research Project of Shanghai Sanda University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01804-4","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:29:55Z","timestamp":1750066195000},"page":"4793-4806","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV against Henoch-Sch\u00f6nlein Purpura Nephritis"],"prefix":"10.1007","volume":"83","author":[{"given":"Shuang","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiou","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"issue":"38","key":"1804_CR1","doi-asserted-by":"publisher","first-page":"e12520","DOI":"10.1097\/MD.0000000000012520","volume":"97","author":"K Wang","year":"2018","unstructured":"Wang, K., Sun, X., Cao, Y., Dai, L., Sun, F., Yu, P., & Dong, L. (2018). Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Sch\u00f6nlein purpura: A retrospective study. Medicine, 97(38), e12520.","journal-title":"Medicine"},{"issue":"1","key":"1804_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12969-019-0311-z","volume":"17","author":"M Jelusic","year":"2019","unstructured":"Jelusic, M., Sestan, M., Cimaz, R., & Ozen, S. (2019). Different histological classifications for Henoch-Sch\u00f6nlein purpura nephritis: Which one should be used? Pediatric Rheumatology Online Journal, 17(1), 10.","journal-title":"Pediatric Rheumatology Online Journal"},{"issue":"5","key":"1804_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1136\/ard-2022-222495","volume":"82","author":"A Kronbichler","year":"2023","unstructured":"Kronbichler, A., Bajema, I., Geetha, D., & S\u00e4emann, M. (2023). Novel aspects in the pathophysiology and diagnosis of glomerular diseases. Annals of the Rheumatic Diseases, 82(5), 585\u2013593.","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"2","key":"1804_CR4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/MOP.0000000000001120","volume":"34","author":"E N\u00fcsken","year":"2022","unstructured":"N\u00fcsken, E., & Weber, L. T. (2022). IgA vasculitis nephritis. Current Opinion in Pediatrics, 34(2), 209\u2013216.","journal-title":"Current Opinion in Pediatrics"},{"issue":"1","key":"1804_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2478\/v10042-008-0086-4","volume":"48","author":"M Danilewicz","year":"2010","unstructured":"Danilewicz, M., & Wagrowska-Danilewicz, M. (2010). Differential glomerular immunoexpression of matrix metalloproteinases MMP-2 and MMP-9 in idiopathic IgA nephropathy and Schoenlein-Henoch nephritis. Folia Histochemica et Cytobiologica, 48(1), 63\u201367.","journal-title":"Folia Histochemica et Cytobiologica"},{"issue":"5","key":"1804_CR6","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s00467-019-04445-x","volume":"35","author":"C Dumont","year":"2020","unstructured":"Dumont, C., M\u00e9rouani, A., Ducruet, T., Benoit, G., Clermont, M. J., Lapeyraque, A. L., Phan, V., & Patey, N. (2020). Clinical relevance of membrane attack complex deposition in children with IgA nephropathy and Henoch-Sch\u00f6nlein purpura. Pediatric Nephrology, 35(5), 843\u2013850.","journal-title":"Pediatric Nephrology"},{"issue":"9","key":"1804_CR7","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1681\/ASN.2004111006","volume":"16","author":"IC Moura","year":"2005","unstructured":"Moura, I. C., Arcos-Fajardo, M., Gdoura, A., Leroy, V., Sadaka, C., Mahlaoui, N., Lepelletier, Y., Vrtovsnik, F., Haddad, E., Benhamou, M., & Monteiro, R. C. (2005). Engagement of transferrin receptor by polymeric IgA1: Evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. Journal of the American Society of Nephrology, 16(9), 2667\u20132676.","journal-title":"Journal of the American Society of Nephrology"},{"issue":"12","key":"1804_CR8","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1016\/j.autrev.2017.10.009","volume":"16","author":"MH Heineke","year":"2017","unstructured":"Heineke, M. H., Ballering, A. V., Jamin, A., Ben Mkaddem, S., Monteiro, R. C., & Van Egmond, M. (2017). New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Sch\u00f6nlein purpura). Autoimmunity Reviews, 16(12), 1246\u20131253.","journal-title":"Autoimmunity Reviews"},{"key":"1804_CR9","doi-asserted-by":"publisher","first-page":"155129","DOI":"10.1016\/j.phymed.2023.155129","volume":"121","author":"Z Shen","year":"2023","unstructured":"Shen, Z., Cui, T., Liu, Y., Wu, S., Han, C., & Li, J. (2023). Astragalus membranaceus and Salvia miltiorrhiza ameliorate diabetic kidney disease via the \u201cgut-kidney axis\u201d. Phytomedicine, 121, 155129.","journal-title":"Phytomedicine"},{"issue":"1","key":"1804_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.55730\/1300-0152.2641","volume":"47","author":"D Zhang","year":"2022","unstructured":"Zhang, D., Li, Z., Gao, Y., & Sun, H. (2022). Astragaloside IV improves renal function and alleviates renal damage and inflammation in rats with chronic glomerulonephritis. Turkish Journal of Biology, 47(1), 61\u201373.","journal-title":"Turkish Journal of Biology"},{"issue":"1","key":"1804_CR11","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/ph16010088","volume":"16","author":"B Xu","year":"2023","unstructured":"Xu, B., Yao, M., Liu, Z., Zhang, S., Wang, B., Han, Y., Gao, J., Wu, D., & Wang, X. (2023). Metabolomic analysis of stephania tetrandra-Astragalus membranaceus herbal pair-improving nephrotic syndrome identifies activation of IL-13\/STAT6 Signaling Pathway. Pharmaceuticals, 16(1), 88.","journal-title":"Pharmaceuticals"},{"key":"1804_CR12","doi-asserted-by":"publisher","first-page":"176632","DOI":"10.1016\/j.ejphar.2024.176632","volume":"975","author":"L Shi","year":"2024","unstructured":"Shi, L., Deng, J., He, J., Zhu, F., Jin, Y., Zhang, X., Ren, Y., & Du, X. (2024). Integrative transcriptomics and proteomics analysis reveal the protection of Astragaloside IV against myocardial fibrosis by regulating senescence. European Journal of Pharmacology, 975, 176632.","journal-title":"European Journal of Pharmacology"},{"issue":"7","key":"1804_CR13","doi-asserted-by":"publisher","first-page":"e0305058","DOI":"10.1371\/journal.pone.0305058","volume":"19","author":"C Luo","year":"2024","unstructured":"Luo, C., Ye, Y., Lv, A., Zuo, W., Yang, Y., Jiang, C., & Ke, J. (2024). The impact of Astragaloside IV on the inflammatory response and gut microbiota in cases of acute lung injury is examined through the utilization of the PI3K\/AKT\/mTOR pathway. PLoS ONE, 19(7), e0305058.","journal-title":"PLoS ONE"},{"key":"1804_CR14","doi-asserted-by":"publisher","first-page":"155346","DOI":"10.1016\/j.phymed.2024.155346","volume":"125","author":"J Xu","year":"2024","unstructured":"Xu, J., Zhang, Z., Ren, D., Liu, L., Xing, H., Wang, D., Wu, Y., Zhang, Y., Chen, Q., & Wang, T. (2024). Astragaloside IV negatively regulates Gpr97-TPL2 signaling to protect against hyperhomocysteine-exacerbated sepsis associated acute kidney injury. Phytomedicine, 125, 155346.","journal-title":"Phytomedicine"},{"issue":"14","key":"1804_CR15","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.18632\/aging.204189","volume":"14","author":"JL Tang","year":"2022","unstructured":"Tang, J. L., Xin, M., & Zhang, L. C. (2022). Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury. Aging, 14(14), 5855\u20135877.","journal-title":"Aging"},{"issue":"9","key":"1804_CR16","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1002\/ptr.8298","volume":"38","author":"M Wang","year":"2022","unstructured":"Wang, M., Li, Q., Wang, S., Zuo, L., Hai, Y., Yuan, S., Li, X., Huang, X., Yang, C., Yao, L., Cao, W., Zuo, G., & Wang, J. (2022). Astragaloside IV protects renal tubular epithelial cells against oxidative stress-induced injury by upregulating CPT1A-mediated HSD17B10 lysine succinylation in diabetic kidney disease. Phytotherapy Research, 38(9), 4519\u20134540.","journal-title":"Phytotherapy Research"},{"key":"1804_CR17","doi-asserted-by":"publisher","first-page":"118517","DOI":"10.1016\/j.jep.2024.118517","volume":"334","author":"J Liu","year":"2024","unstructured":"Liu, J., Ren, J., Zhou, L., Tan, K., Du, D., Xu, L., Cao, W., & Zhang, Y. (2024). Proteomic and lipidomic analysis of the mechanism underlying Astragaloside IV in mitigating ferroptosis through hypoxia-inducible factor 1\u03b1\/heme oxygenase 1 pathway in renal tubular epithelial cells in diabetic kidney disease. Journal of Ethnopharmacology, 334, 118517.","journal-title":"Journal of Ethnopharmacology"},{"key":"1804_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.658236","volume":"12","author":"C Liu","year":"2021","unstructured":"Liu, C., Li, X., Shuai, L., Dang, X., Peng, F., Zhao, M., Xiong, S., Liu, Y., & He, Q. (2021). Astragaloside IV inhibits galactose-deficient IgA1 secretion via miR-98-5p in pediatric IgA nephropathy. Frontiers in Pharmacology, 12, 658236.","journal-title":"Frontiers in Pharmacology"},{"key":"1804_CR19","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1646905","volume":"2020","author":"Z Zhou","year":"2020","unstructured":"Zhou, Z., Chen, B., Chen, S., Lin, M., Chen, Y., Jin, S., Chen, W., & Zhang, Y. (2020). Applications of network pharmacology in traditional chinese medicine research. Evidence-Based Complementary and Alternative Medicine, 2020, 1646905.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"1804_CR20","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.2147\/DDDT.S450324","volume":"18","author":"B Cai","year":"2024","unstructured":"Cai, B., Qi, M., Zhang, X., & Zhang, D. (2024). Integrating network pharmacology with in vitro experiments to validate the efficacy of celastrol against hepatocellular carcinoma through ferroptosis. Drug Design, Development and Therapy, 18, 3121\u20133141.","journal-title":"Drug Design, Development and Therapy"},{"key":"1804_CR21","doi-asserted-by":"publisher","first-page":"e33308","DOI":"10.1016\/j.heliyon.2024.e33308","volume":"10","author":"Z Chun-Peng","year":"2024","unstructured":"Chun-Peng, Z., Tian, C., & Xue, Y. (2024). Pharmacological mechanisms of Taohe Chengqi decoction in diabetic cardiovascular complications: A systematic review, network pharmacology and molecular docking. Heliyon, 10, e33308.","journal-title":"Heliyon"},{"key":"1804_CR22","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.2147\/DDDT.S404710","volume":"17","author":"S Yuan","year":"2023","unstructured":"Yuan, S., Zuo, B., Zhou, S. C., Wang, M., Tan, K. Y., Chen, Z. W., & Cao, W. F. (2023). Integrating network pharmacology and experimental validation to explore the pharmacological mechanism of Astragaloside IV in treating bleomycin-induced pulmonary fibrosis. Drug Design, Development and Therapy, 17, 1289\u20131302.","journal-title":"Drug Design, Development and Therapy"},{"issue":"9","key":"1804_CR23","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1080\/17460441.2016.1216967","volume":"11","author":"S Kim","year":"2016","unstructured":"Kim, S. (2016). Getting the most out of PubChem for virtual screening. Expert Opinion on Drug Discovery, 11(9), 843\u2013855.","journal-title":"Expert Opinion on Drug Discovery"},{"issue":"23","key":"1804_CR24","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1093\/bioinformatics\/btt540","volume":"29","author":"D Gfeller","year":"2013","unstructured":"Gfeller, D., Michielin, O., & Zoete, V. (2013). Shaping the interaction landscape of bioactive molecules. Bioinformatics, 29(23), 3073\u20133079.","journal-title":"Bioinformatics"},{"key":"1804_CR25","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1093\/nar\/gku1205","volume":"43","author":"JS Amberger","year":"2015","unstructured":"Amberger, J. S., Bocchini, C. A., Schiettecatte, F., Scott, A. F., & Hamosh, A. (2015). OMIM.org: Online mendelian inheritance in man (OMIM\u00ae), an online catalog of human genes and genetic disorders. Nucleic Acids Research, 43, 789\u2013798.","journal-title":"Nucleic Acids Research"},{"key":"1804_CR26","doi-asserted-by":"publisher","first-page":"baq020","DOI":"10.1093\/database\/baq020","volume":"2010","author":"M Safran","year":"2010","unstructured":"Safran, M., Dalah, I., Alexander, J., Rosen, N., Iny Stein, T., Shmoish, M., Nativ, N., Bahir, I., Doniger, T., Krug, H., Sirota-Madi, A., Olender, T., Golan, Y., Stelzer, G., Harel, A., & Lancet, D. (2010). GeneCards version 3: The human gene integrator. Database, 2010, baq020.","journal-title":"Database"},{"issue":"D1","key":"1804_CR27","first-page":"D845","volume":"48","author":"J Pi\u00f1ero","year":"2020","unstructured":"Pi\u00f1ero, J., Ram\u00edrez-Anguita, J. M., Sa\u00fcch-Pitarch, J., Ronzano, F., Centeno, E., Sanz, F., & Furlong, L. I. (2020). The DisGeNET knowledge platform for disease genomics: 2019 update. Nucleic Acids Research, 48(D1), D845\u2013D855.","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"1804_CR28","doi-asserted-by":"publisher","first-page":"D607-","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., Simonovic, M., Doncheva, N. T., Morris, J. H., Bork, P., Jensen, L. J., & Mering, C. V. (2019). STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Research, 47(D1), D607-\u2013D6613.","journal-title":"Nucleic Acids Research"},{"issue":"2","key":"1804_CR29","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva, N. T., Morris, J. H., Gorodkin, J., & Jensen, L. J. (2019). Cytoscape stringApp: Network analysis and visualization of proteomics data. Journal of Proteome Research, 18(2), 623\u2013632.","journal-title":"Journal of Proteome Research"},{"issue":"6","key":"1804_CR30","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.chom.2015.11.002","volume":"18","author":"S Tripathi","year":"2015","unstructured":"Tripathi, S., Pohl, M. O., Zhou, Y., Rodriguez-Frandsen, A., Wang, G., Stein, D. A., Moulton, H. M., DeJesus, P., Che, J., Mulder, L. C., Y\u00e1ng\u00fcez, E., Andenmatten, D., Pache, L., Manicassamy, B., Albrecht, R. A., Gonzalez, M. G., Nguyen, Q., Brass, A., Elledge, S., White, M., Shapira, S., Hacohen, N., Karlas, A., Meyer, T. F., Shales, M., Gatorano, A., Johnson, J. R., Jang, G., Johnson, T., Verschueren, E., Sanders, D., Krogan, N., Shaw, M., K\u00f6nig, R., Stertz, S., Garc\u00eda-Sastre, A., & Chanda, S. K. (2015). Meta-and orthogonal integration of influenza \u201cOMICs\u201d data defines a role for UBR4 in virus budding. Cell Host and Microbe, 18(6), 723\u2013735.","journal-title":"Cell Host and Microbe"},{"issue":"1","key":"1804_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019). Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nature Communications, 10(1), 1523.","journal-title":"Nature Communications"},{"issue":"D1","key":"1804_CR32","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Matsuura, Y., & Ishiguro-Watanabe, M. (2025). KEGG: Biological systems database as a model of the real world. Nucleic Acids Research, 53(D1), D672\u2013D677.","journal-title":"Nucleic Acids Research"},{"issue":"11","key":"1804_CR33","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. (2019). Toward understanding the origin and evolution of cellular organisms. Protein Science, 28(11), 1947\u20131951.","journal-title":"Protein Science"},{"issue":"1","key":"1804_CR34","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M., & Goto, S. (2000). KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Research, 28(1), 27\u201330.","journal-title":"Nucleic Acids Research"},{"issue":"21","key":"1804_CR35","doi-asserted-by":"publisher","first-page":"3755","DOI":"10.1093\/bioinformatics\/bty419","volume":"34","author":"AS Rose","year":"2018","unstructured":"Rose, A. S., Bradley, A. R., Valasatava, Y., Duarte, J. M., Prlic, A., & Rose, P. W. (2018). NGL viewer: Web-based molecular graphics for large complexes. Bioinformatics, 34(21), 3755\u20133758.","journal-title":"Bioinformatics"},{"issue":"W1","key":"1804_CR36","doi-asserted-by":"publisher","first-page":"W431","DOI":"10.1093\/nar\/gkab314","volume":"49","author":"D Sehnal","year":"2021","unstructured":"Sehnal, D., Bittrich, S., Deshpande, M., Svobodov\u00e1, R., Berka, K., Bazgier, V., Velankar, S., Burley, S. K., Ko\u010da, J., & Rose, A. S. (2021). Mol* viewer: Modern web app for 3D visualization and analysis of large biomolecular structures. Nucleic Acids Research, 49(W1), W431\u2013W437.","journal-title":"Nucleic Acids Research"},{"issue":"2","key":"1804_CR37","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O., & Olson, A. J. (2010). AutoDock vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455\u2013461.","journal-title":"Journal of Computational Chemistry"},{"issue":"1","key":"1804_CR38","first-page":"57","volume":"17","author":"MF Sanner","year":"1999","unstructured":"Sanner, M. F. (1999). Python: A programming language for software integration and development. Journal of Molecular Graphics and Modelling, 17(1), 57\u201361.","journal-title":"Journal of Molecular Graphics and Modelling"},{"issue":"8","key":"1804_CR39","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","volume":"61","author":"J Eberhardt","year":"2021","unstructured":"Eberhardt, J., Santos-Martins, D., Tillack, A. F., & Forli, S. (2021). AutoDock vina 1.2.0: New docking methods, expanded force field, and python bindings. Journal of Chemical Information and Modeling, 61(8), 3891\u20133898.","journal-title":"Journal of Chemical Information and Modeling"},{"issue":"3","key":"1804_CR40","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1083\/jcb.123.3.513","volume":"123","author":"C Schl\u00fcter","year":"1993","unstructured":"Schl\u00fcter, C., Duchrow, M., Wohlenberg, C., Becker, M. H., Key, G., Flad, H. D., & Gerdes, J. (1993). The cell proliferation-associated antigen of antibody Ki-67: A very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. Journal of Cell Biology, 123(3), 513\u2013522.","journal-title":"Journal of Cell Biology"},{"key":"1804_CR41","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2147\/PHMT.S379862","volume":"14","author":"M Sestan","year":"2023","unstructured":"Sestan, M., & Jelusic, M. (2023). Diagnostic and management strategies of IgA vasculitis Nephritis\/Henoch-Sch\u00f6nlein purpura nephritis in pediatric patients: Current perspectives. Pediatric Health, Medicine and Therapeutics, 14, 89\u201398.","journal-title":"Pediatric Health, Medicine and Therapeutics"},{"issue":"14","key":"1804_CR42","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.addr.2010.08.011","volume":"62","author":"YM Scindia","year":"2010","unstructured":"Scindia, Y. M., Deshmukh, U. S., & Bagavant, H. (2010). Mesangial pathology in glomerular disease: Targets for therapeutic intervention. Advanced Drug Delivery Reviews, 62(14), 1337\u20131343.","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"7","key":"1804_CR43","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1002\/cbin.11142","volume":"43","author":"Q Zhang","year":"2019","unstructured":"Zhang, Q., Yan, L., Chen, M., Gui, M., Lu, L., Deng, F., & Ren, Z. (2019). IgA1 isolated from Henoch-Sch\u00f6nlein purpura children promotes proliferation of human mesangial cells in vitro. Cell Biology International, 43(7), 760\u2013769.","journal-title":"Cell Biology International"},{"issue":"5","key":"1804_CR44","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00467-015-3290-4","volume":"31","author":"K Kamei","year":"2016","unstructured":"Kamei, K., Ogura, M., Sato, M., Ito, S., & Ishikura, K. (2016). Evolution of IgA nephropathy into anaphylactoid purpura in six cases-further evidence that IgA nephropathy and Henoch-Schonlein purpura nephritis share common pathogenesis. Pediatric Nephrology, 31(5), 779\u2013785.","journal-title":"Pediatric Nephrology"},{"key":"1804_CR45","doi-asserted-by":"publisher","first-page":"e15282","DOI":"10.1111\/ped.15282","volume":"64","author":"M Kurokawa","year":"2022","unstructured":"Kurokawa, M., Maehara, K., Kaku, Y., & Honjo, S. (2022). Necessity and choice of therapy for Henoch-Sch\u00f6nlein purpura nephritis. Pediatrics International, 64, e15282.","journal-title":"Pediatrics International"},{"key":"1804_CR46","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1515\/biol-2019-0058","volume":"14","author":"P Zhou","year":"2019","unstructured":"Zhou, P., Xiao, Q., Chen, L., Zou, Z. J., Wang, Y. Q., Zhu, L., Yu, H. Y., Zhao, C. G., Wu, Y. B., & Du, X. Y. (2019). Effects of huaiqihuang granules adjuvant therapy in children with primary nephrotic syndrome. Open Life Sciences, 14, 519\u2013527.","journal-title":"Open Life Sciences"},{"issue":"6","key":"1804_CR47","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1152\/ajprenal.00112.2007","volume":"293","author":"G Ding","year":"2007","unstructured":"Ding, G., Zhang, A., Huang, S., Pan, X., Zhen, G., Chen, R., & Yang, T. (2007). ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. American Journal of Physiology Renal Physiology, 293(6), 1889\u20131897.","journal-title":"American Journal of Physiology Renal Physiology"},{"key":"1804_CR48","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.3389\/fimmu.2018.01982","volume":"9","author":"J Bai","year":"2018","unstructured":"Bai, J., Wu, L., Chen, X., Wang, L., Li, Q., Zhang, Y., Wu, J., Cai, G., & Chen, X. (2018). Suppressor of cytokine signaling-1\/STAT1 regulates renal inflammation in mesangial proliferative glomerulonephritis models. Frontiers in Immunology, 9, 1982.","journal-title":"Frontiers in Immunology"},{"key":"1804_CR49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mehy.2016.10.014","volume":"97","author":"ES Mirfazeli","year":"2016","unstructured":"Mirfazeli, E. S., Marashi, S. A., & Kalantari, S. (2016). In silico prediction of specific pathways that regulate mesangial cell proliferation in IgA nephropathy. Medical Hypotheses, 97, 38\u201345.","journal-title":"Medical Hypotheses"},{"issue":"3","key":"1804_CR50","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00709-013-0548-1","volume":"251","author":"E Wawryk-Gawda","year":"2014","unstructured":"Wawryk-Gawda, E., Chyli\u0144ska-Wrzos, P., Lis-Sochocka, M., Ch\u0142apek, K., Bulak, K., J\u0119drych, M., & Jod\u0142owska-J\u0119drych, B. (2014). P53 protein in proliferation, repair and apoptosis of cells. Protoplasma, 251(3), 525\u2013533.","journal-title":"Protoplasma"},{"key":"1804_CR51","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.biopha.2017.01.019","volume":"89","author":"D Roy","year":"2017","unstructured":"Roy, D., Sheng, G. Y., Herve, S., Carvalho, E., Mahanty, A., Yuan, S., & Sun, L. (2017). Interplay between cancer cell cycle and metabolism: Challenges, targets and therapeutic opportunities. Biomedicine and Pharmacotherapy, 89, 288\u2013296.","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"8","key":"1804_CR52","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1111\/jog.15708","volume":"49","author":"T Zhao","year":"2023","unstructured":"Zhao, T., Xiao, X., Li, L., Wu, X., & Yuan, T. (2023). Rosline promotes p21 expression to inhibit ovarian cancer cell proliferation via p53-independent pathway. The Journal of Obstetrics and Gynaecology Research, 49(8), 2126\u20132134.","journal-title":"The Journal of Obstetrics and Gynaecology Research"},{"key":"1804_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0031-7","volume":"16","author":"ZS Wang","year":"2015","unstructured":"Wang, Z. S., Xiong, F., Xie, X. H., Chen, D., Pan, J. H., & Cheng, L. (2015). Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress. BMC Nephrology, 16, 44.","journal-title":"BMC Nephrology"},{"issue":"2","key":"1804_CR54","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.pharep.2018.12.008","volume":"71","author":"Y Su","year":"2019","unstructured":"Su, Y., Chen, Q., Ma, K., Ju, Y., Ji, T., Wang, Z., Li, W., & Li, W. (2019). Astragaloside IV inhibits palmitate-mediated oxidative stress and fibrosis in human glomerular mesangial cells via downregulation of CD36 expression. Pharmacological Reports, 71(2), 319\u2013329.","journal-title":"Pharmacological Reports"},{"issue":"1","key":"1804_CR55","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3892\/ijmm.2014.1741","volume":"34","author":"L Sun","year":"2014","unstructured":"Sun, L., Li, W., Li, W., Xiong, L., Li, G., & Ma, R. (2014). Astragaloside IV prevents damage to human mesangial cells through the inhibition of the NADPH oxidase\/ROS\/Akt\/NF-\u03baB pathway under high glucose conditions. International Journal of Molecular Medicine, 34(1), 167\u2013176.","journal-title":"International Journal of Molecular Medicine"},{"issue":"12","key":"1804_CR56","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1002\/ptr.6772","volume":"34","author":"R Lu","year":"2020","unstructured":"Lu, R., Chen, J., Liu, B., Lin, H., Bai, L., Zhang, P., Chen, D., Li, H., Li, J., Pang, Y., Zhou, Y., Zhou, J., & Wu, J. (2020). Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K\/AKT\/AS160 pathway. Phytotherapy Research, 34(12), 3236\u20133248.","journal-title":"Phytotherapy Research"},{"key":"1804_CR57","doi-asserted-by":"publisher","first-page":"111670","DOI":"10.1016\/j.yexcr.2019.111670","volume":"385","author":"X Mao","year":"2019","unstructured":"Mao, X., Xu, Z., Xu, X., Zeng, M., Zhao, Z., Zhang, Z., Ding, X., & Wu, H. (2019). TGF-\u03b21 inhibits the autophagy of podocytes by activating mTORC1 in IgA nephropathy. Experimental Cell Research, 385, 111670.","journal-title":"Experimental Cell Research"},{"issue":"4","key":"1804_CR58","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/jcb.22789","volume":"111","author":"H Wu","year":"2010","unstructured":"Wu, H., Jiang, W., Zhang, Y., Liu, Y., Zhao, Z., Guo, M., Ma, D., & Zhang, Z. (2010). Regulation of intracellular decorin via proteasome degradation in rat mesangial cells. Journal of Cellular Biochemistry, 111(4), 1010\u20131009.","journal-title":"Journal of Cellular Biochemistry"},{"key":"1804_CR59","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.carbpol.2015.02.012","volume":"125","author":"Y Wang","year":"2015","unstructured":"Wang, Y., Wang, Y., Liu, D., Wang, W., Zhao, H., Wang, M., & Yin, H. (2015). Cordyceps sinensis polysaccharide inhibits PDGF-BB-induced inflammation and ROS production in human mesangial cells. Carbohydrate Polymers, 125, 135\u2013145.","journal-title":"Carbohydrate Polymers"},{"key":"1804_CR60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42881","volume":"8","author":"L Grimm","year":"2019","unstructured":"Grimm, L., Nakajima, H., Chaudhury, S., Bower, N. I., Okuda, K. S., Cox, A. G., Harvey, N. L., Koltowska, K., Mochizuki, N., & Hogan, B. M. (2019). Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. eLife, 8, e42881.","journal-title":"eLife"},{"issue":"2","key":"1804_CR61","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/pros.2990260205","volume":"26","author":"ML Cher","year":"1995","unstructured":"Cher, M. L., Chew, K., Rosenau, W., & Carroll, P. R. (1995). Cellular proliferation in prostatic adenocarcinoma as assessed by bromodeoxyuridine uptake and Ki-67 and PCNA expression. The Prostate, 26(2), 87\u201393.","journal-title":"The Prostate"},{"issue":"5","key":"1804_CR62","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.acthis.2016.05.002","volume":"118","author":"M Jur\u00edkov\u00e1","year":"2016","unstructured":"Jur\u00edkov\u00e1, M., Danihel, \u013d., Pol\u00e1k, \u0160., & Varga, I. (2016). Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer. Acta Histochemica, 118(5), 544\u2013552.","journal-title":"Acta Histochemica"},{"issue":"1","key":"1804_CR63","first-page":"3","volume":"22","author":"A Noske","year":"2009","unstructured":"Noske, A., Lipka, S., Budczies, J., M\u00fcller, K., Loddenkemper, C., Buhr, H. J., & Kruschewski, M. (2009). Combination of p53 expression and p21 loss has an independent prognostic impact on sporadic colorectal cancer. Oncology Reports, 22(1), 3\u20139.","journal-title":"Oncology Reports"},{"key":"1804_CR64","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4103\/0973-1296.157698","volume":"11","author":"S Sikdar","year":"2015","unstructured":"Sikdar, S., Mukherjee, A., & Khuda-Bukhsh, A. R. (2015). Anti-lung cancer potential of pure esteric-glycoside condurangogenin A against nonsmall-cell lung cancer cells in vitro via p21\/p53 mediated cell cycle modulation and DNA damage-induced apoptosis. Pharmacognosy Magazine, 11, 73\u201385.","journal-title":"Pharmacognosy Magazine"},{"key":"1804_CR65","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.biopha.2017.04.127","volume":"91","author":"H Luo","year":"2017","unstructured":"Luo, H., Yao, L., Zhang, Y., & Li, R. (2017). Liquid chromatography-mass spectrometry-based quantitative proteomics analysis reveals chondroprotective effects of Astragaloside IV in interleukin-1\u03b2-induced SW1353 chondrocyte-like cells. Biomedicine and Pharmacotherapy, 91, 796\u2013802.","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"6","key":"1804_CR66","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.jtcme.2024.03.015","volume":"14","author":"Y Zhou","year":"2024","unstructured":"Zhou, Y., Wang, H., Bi, T., Liang, P., Liu, X., Shen, H., Sun, Q., Luo, G., Liu, P., Yang, S., & Ren, W. (2024). Zhilong Huoxue Tongyu capsule protects against atherosclerosis by suppressing EndMT via modulating Hippo\/YAP signaling pathway. Journal of Traditional and Complementary Medicine, 14(6), 656\u2013665.","journal-title":"Journal of Traditional and Complementary Medicine"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01804-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01804-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01804-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T06:01:53Z","timestamp":1764914513000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01804-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":66,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1804"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01804-4","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"assertion":[{"value":"9 June 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This research was approved by the Ethics Committee of Shanghai Sanda University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}}]}}