{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:03:41Z","timestamp":1788311021076,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01832-0","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T21:43:23Z","timestamp":1752961403000},"page":"5141-5166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bryophyllum pinnatum (L.) Pers. Modulates Multiple Neuroprotective Targets in Alzheimer\u2019s Disease: Evidence from Computational and Experimental Validation"],"prefix":"10.1007","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-269X","authenticated-orcid":false,"given":"Laxmi","family":"Pattanashetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj M.","family":"Donagannavar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Jigalur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal S.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"issue":"10284","key":"1832_CR1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Ch\u00e9telat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021). Alzheimer\u2019s disease. The Lancet, 397(10284), 1577\u20131590. https:\/\/doi.org\/10.1016\/S0140-6736(20)32205-4.","journal-title":"The Lancet"},{"issue":"11","key":"1832_CR2","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","volume":"18","author":"S Khan","year":"2020","unstructured":"Khan, S., Barve, K. H., & Kumar, M. S. (2020). Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease. Current Neuropharmacology, 18(11), 1106\u20131125. https:\/\/doi.org\/10.2174\/1570159X18666200528142429.","journal-title":"Current Neuropharmacology"},{"issue":"3","key":"1832_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/S1474-4422(20)30440-3","volume":"20","author":"J Graff-Radford","year":"2021","unstructured":"Graff-Radford, J., Yong, K. X. X., Apostolova, L. G., Bouwman, F. H., Carrillo, M., Dickerson, B. C., Rabinovici, G. D., Schott, J. M., Jones, D. T., & Murray, M. E. (2021). New insights into atypical Alzheimer\u2019s disease in the era of biomarkers. The Lancet Neurology, 20(3), 222\u2013234. https:\/\/doi.org\/10.1016\/S1474-4422(20)30440-3.","journal-title":"The Lancet Neurology"},{"issue":"1","key":"1832_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.4103\/0253-7613.201016","volume":"49","author":"LA Pattanashetti","year":"2017","unstructured":"Pattanashetti, L. A., Taranalli, A. D., Parvatrao, V., Malabade, R. H., & Kumar, D. (2017). Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine-induced amnesia in rats. Indian Journal of Pharmacology, 49(1), 60\u201364. https:\/\/doi.org\/10.4103\/0253-7613.201016.","journal-title":"Indian Journal of Pharmacology"},{"key":"1832_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102199","volume":"94","author":"N Liu","year":"2024","unstructured":"Liu, N., Liang, X., Chen, Y., & Xie, L. (2024). Recent trends in treatment strategies for Alzheimer\u2019s disease and the challenges: A topical advancement. Ageing Research Reviews, 94, 102199 https:\/\/doi.org\/10.1016\/j.arr.2024.102199.","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"1832_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/NG.2024.01X","volume":"12","author":"DR Brown","year":"2024","unstructured":"Brown, D. R., & Tahsin, R. (2024). Experimental AAV-mediated APOE2 delivery for APOE4 carriers: Safety and initial cognition outcomes. Neurogenetics, 12(1), 45\u201358. https:\/\/doi.org\/10.1001\/NG.2024.01X.","journal-title":"Neurogenetics"},{"key":"1832_CR7","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3389\/fnagi.2019.00369","volume":"11","author":"GK Bhatti","year":"2020","unstructured":"Bhatti, G. K., Reddy, A. P., & Bhatti, J. S. (2020). Lifestyle modifications and nutritional interventions in aging-associated cognitive decline and Alzheimer\u2019s disease. Frontiers in Aging Neuroscience, 11, 369 https:\/\/doi.org\/10.3389\/fnagi.2019.00369.","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"1832_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-024-00900-6","volume":"19","author":"Z Chen","year":"2024","unstructured":"Chen, Z., Wang, X., Du, S., Liu, Q., Xu, Z., Guo, Y., & Lin, X. (2024). A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer\u2019s disease based on the neuroinflammatory. Chinese Medicine, 19(1), 35 https:\/\/doi.org\/10.1186\/s13020-024-00900-6.","journal-title":"Chinese Medicine"},{"issue":"2","key":"1832_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3456\/ptrev.v10i2.3456","volume":"10","author":"S Hariprasad","year":"2023","unstructured":"Hariprasad, S., & Raveendran, R. (2023). Phytotherapeutics against Alzheimer\u2019s disease: Mechanism, molecular targets and challenges for drug development. Phytotherapeutics Review, 10(2), 123\u2013145. https:\/\/doi.org\/10.3456\/ptrev.v10i2.3456.","journal-title":"Phytotherapeutics Review"},{"issue":"8","key":"1832_CR10","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.2174\/1570159X20666211217163540","volume":"20","author":"C Choy Ker Woon","year":"2022","unstructured":"Choy Ker Woon, C., Wong Kah Hui, K., Abas, R., Haron, M. H., Das, S., & Teoh Seong Lin, T. (2022). Natural product\u2013based nanomedicine: Recent advances and issues for the treatment of Alzheimer\u2019s disease. Current Neuropharmacology, 20(8), 1498\u20131518. https:\/\/doi.org\/10.2174\/1570159X20666211217163540.","journal-title":"Current Neuropharmacology"},{"key":"1832_CR11","first-page":"876","volume":"3","author":"S Sheikh","year":"2025","unstructured":"Sheikh, S., Bhandakkar, N., Khairkar, P. & & Mahajan, R. (2025). Pharmacological and Phytochemical Profile of Bryophyllum Pinnatum. International Journal of Pharmacy and Pharmaceutical Sciences, 3, 876\u2013882.","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"issue":"3","key":"1832_CR12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.5530\/pj.2018.3.82","volume":"10","author":"OA Ojo","year":"2018","unstructured":"Ojo, O. A., Ojo, A. B., Ajiboye, B. O., Olaiya, O., Akawa, A., Olaoye, O., Anifowose, O. O., Idowu, O., Olasehinde, O., Obafemi, T., & Awe, J. (2018). Inhibitory effect of Bryophyllum pinnatum (Lam.) Oken leaf extract and their fractions on \u03b1-amylase, \u03b1-glucosidase and cholinesterase enzyme. Pharmacognosy Journal, 10(3), 497\u2013506.","journal-title":"Pharmacognosy Journal"},{"issue":"6","key":"1832_CR13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.9734\/indj\/2024\/v21i6452","volume":"21","author":"PO Uahomo","year":"2024","unstructured":"Uahomo, P. O., & Isirima, J. C. (2024). Neuroprotective effects of Bryophyllum pinnatum against ketamine-induced neurotoxicity in Wistar rats: Neurochemical, oxidative stress, and histological investigation. International Neuropsychiatric Disease Journal, 21(6), 19\u201340. https:\/\/doi.org\/10.9734\/indj\/2024\/v21i6452.","journal-title":"International Neuropsychiatric Disease Journal"},{"issue":"9","key":"1832_CR14","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1007\/s12298-024-01509-7","volume":"30","author":"G Sharma","year":"2024","unstructured":"Sharma, G., Jangra, A., Sihag, S., Chaturvedi, S., Yadav, S., & Chhokar, V. (2024). Bryophyllum pinnatum (Lam.) Oken: Unravelling therapeutic potential and navigating toxicity. Physiology and Molecular Biology of Plants, 30(9), 1413\u20131427. https:\/\/doi.org\/10.1007\/s12298-024-01509-7.","journal-title":"Physiology and Molecular Biology of Plants"},{"issue":"4","key":"1832_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/15376516.2021.1995557","volume":"32","author":"JO Ogidigo","year":"2022","unstructured":"Ogidigo, J. O., Anosike, C. A., Joshua, P. E., Ibeji, C. U., Nwanguma, B. C., & Nwodo, O. F. C. (2022). Neuroprotective effect of Bryophyllum pinnatum flavonoids against aluminum chloride-induced neurotoxicity in rats. Toxicology Mechanisms and Methods, 32(4), 243\u2013258. https:\/\/doi.org\/10.1080\/15376516.2021.1995557.","journal-title":"Toxicology Mechanisms and Methods"},{"issue":"4","key":"1832_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.bjp.2019.01.012","volume":"29","author":"JM Fernandes","year":"2019","unstructured":"Fernandes, J. M., Cunha, L. M., Azevedo, E. P., Louren\u00e7o, E. M. G., Fernandes-Pedrosa, M. F., & Zucolotto, S. M. (2019). Kalanchoe laciniata and Bryophyllum pinnatum: An updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology. Revista Brasileira de Farmacognosia, 29(4), 529\u2013558. https:\/\/doi.org\/10.1016\/j.bjp.2019.01.012.","journal-title":"Revista Brasileira de Farmacognosia"},{"issue":"3","key":"1832_CR17","first-page":"423","volume":"3","author":"AK Prasad","year":"2012","unstructured":"Prasad, A. K., Kumar, S., Iyer, S. V., Sudani, R. J., & Vaidya, S. K. (2012). Pharmacognostical, phytochemical and pharmacological review on Bryophyllum pinnata. International Journal of Pharmaceutical and Biological Archive, 3(3), 423\u2013433.","journal-title":"International Journal of Pharmaceutical and Biological Archive"},{"issue":"6","key":"1832_CR18","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.13040\/IJPSR.0975-8232.5","volume":"5","author":"C Gurnani","year":"2014","unstructured":"Gurnani, C., Kumar, V., Mukhija, S., Narula, P., & Bhola, R. (2014). Conservation of medicinal plant Bryophyllum pinnatum (Lam.) Kurz by in vitro nodal culture. International Journal of Pharmaceutical Sciences and Research, 5(6), 2406 https:\/\/doi.org\/10.13040\/IJPSR.0975-8232.5.","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"issue":"1","key":"1832_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-145","volume":"14","author":"M Ayaz","year":"2014","unstructured":"Ayaz, M., Junaid, M., Ahmed, J., Ullah, F., Sadiq, A., Ahmad, S., & Imran, M. (2014). Phenolic contents, antioxidant and anticholinesterase potentials of crude extract, subsequent fractions and crude saponins from Polygonum hydropiper L. BMC Complementary and Alternative Medicine, 14(1), 145 https:\/\/doi.org\/10.1186\/1472-6882-14-145.","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"1832_CR20","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8706589","volume":"2019","author":"Q Zeng","year":"2019","unstructured":"Zeng, Q., Li, L., Jin, Y., Chen, Z., Duan, L., Cao, M., Ma, M., & Wu, Z. (2019). A network pharmacology approach to reveal the underlying mechanisms of Paeonia lactiflora Pall. on the treatment of Alzheimer\u2019s disease. Evidence-Based Complementary and Alternative Medicine, 2019, 8706589 https:\/\/doi.org\/10.1155\/2019\/8706589.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"1","key":"1832_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/nar\/gkg034","volume":"31","author":"C von Mering","year":"2003","unstructured":"von Mering, C., Huynen, M., Jaeggi, D., Schmidt, S., Bork, P., & Snel, B. (2003). STRING: A database of predicted functional associations between proteins. Nucleic Acids Research, 31(1), 258\u2013261. https:\/\/doi.org\/10.1093\/nar\/gkg034.","journal-title":"Nucleic Acids Research"},{"issue":"Database issue","key":"1832_CR22","doi-asserted-by":"publisher","first-page":"D561","DOI":"10.1093\/nar\/gkq973","volume":"39","author":"D Szklarczyk","year":"2011","unstructured":"Szklarczyk, D., Franceschini, A., Kuhn, M., Simonovic, M., Roth, A., Minguez, P., Doerks, T., Stark, M., Muller, J., Bork, P., Jensen, L. J., & von Mering, C. (2011). The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Research, 39(Database issue), D561\u2013D568. https:\/\/doi.org\/10.1093\/nar\/gkq973.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"1832_CR23","doi-asserted-by":"publisher","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","volume":"54","author":"G Stelzer","year":"2016","unstructured":"Stelzer, G., Rosen, N., Plaschkes, I., Zimmerman, S., Twik, M., Fishilevich, S., Iny Stein, T., Nudel, R., Lieder, I., Mazor, Y., Kaplan, S., Dahary, D., Warshawsky, D., Guan-Golan, Y., Kohn, A., Rappaport, N., Safran, M., & Lancet, D. (2016). The GeneCards suite: From gene data mining to disease genome sequence analyses. Current Protocols in Bioinformatics, 54(1), 1.30.1\u20131.30.33. https:\/\/doi.org\/10.1002\/cpbi.5.","journal-title":"Current Protocols in Bioinformatics"},{"issue":"D1","key":"1832_CR24","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2017","unstructured":"Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017). KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Research, 45(D1), D353\u2013D361. https:\/\/doi.org\/10.1093\/nar\/gkw1092.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"1832_CR25","first-page":"2726","volume":"8","author":"KC Devraj","year":"2019","unstructured":"Devraj, K. C., Anuradha, K. N., Santosh, P., & Ashma, K. C. (2019). A comparative pharmacognostic evaluation of two source plants of pashanabheda Bergenia ligulata Linn. and Bryophyllum pinnatum Lam (Oken). Journal of Pharmacognosy and Phytochemistry, 8(1), 2726\u20132732.","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"issue":"D1","key":"1832_CR26","doi-asserted-by":"publisher","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","volume":"46","author":"DS Wishart","year":"2018","unstructured":"Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., Assempour, N., Iynkkaran, I., Liu, Y., Maciejewski, A., Gale, N., Wilson, A., Chin, L., Cummings, R., Le, D., & Wilson, M. (2018). DrugBank 5.0: A major update to the DrugBank database for 2018. Nucleic Acids Research, 46(D1), D1074\u2013D1082. https:\/\/doi.org\/10.1093\/nar\/gkx1037.","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"1832_CR27","doi-asserted-by":"publisher","first-page":"D1398","DOI":"10.1093\/nar\/gkab953","volume":"50","author":"Y Zhou","year":"2022","unstructured":"Zhou, Y., Zhang, Y., Lian, X., Li, F., Wang, C., Zhu, F., Qiu, Y., Chen, Y., Ren, Z., Zhuang, L., Fu, X., Zhao, J., Tan, Y., Feng, Y., Guo, Z., & Chen, Y. Z. (2022). Therapeutic target database update 2022: Facilitating drug discovery with enriched comparative data of targeted agents. Nucleic Acids Research, 50(D1), D1398\u2013D1407. https:\/\/doi.org\/10.1093\/nar\/gkab953.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"1832_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019). Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nature Communications, 10(1), 1523 https:\/\/doi.org\/10.1038\/s41467-019-09234-6.","journal-title":"Nature Communications"},{"issue":"W1","key":"1832_CR29","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gku293","volume":"42","author":"D Gfeller","year":"2014","unstructured":"Gfeller, D., Grosdidier, A., Wirth, M., Daina, A., Michielin, O., & Zoete, V. (2014). SwissTargetPrediction: A web server for target prediction of bioactive small molecules. Nucleic Acids Research, 42(W1), W32\u2013W38. https:\/\/doi.org\/10.1093\/nar\/gku293.","journal-title":"Nucleic Acids Research"},{"issue":"W1","key":"1832_CR30","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina, A., Michielin, O., & Zoete, V. (2019). SwissTargetPrediction: Updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Research, 47(W1), W357\u2013W364. https:\/\/doi.org\/10.1093\/nar\/gkz382.","journal-title":"Nucleic Acids Research"},{"issue":"16","key":"1832_CR31","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry, 30(16), 2785\u20132791. https:\/\/doi.org\/10.1002\/jcc.21256.","journal-title":"Journal of Computational Chemistry"},{"issue":"2","key":"1832_CR32","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O., & Olson, A. J. (2010). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455\u2013461. https:\/\/doi.org\/10.1002\/jcc.21334.","journal-title":"Journal of Computational Chemistry"},{"key":"1832_CR33","volume-title":"Discovery Studio Modeling Environment, Release 2017","author":"Dassault Syst\u00e8mes BIOVIA.","year":"2016","unstructured":"Dassault Syst\u00e8mes BIOVIA. (2016). Discovery Studio Modeling Environment, Release 2017. (Dassault Syst\u00e8mes."},{"issue":"Pt 6 No 1","key":"1832_CR34","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1107\/S0907444902003451","volume":"58","author":"HM Berman","year":"2002","unstructured":"Berman, H. M., Battistuz, T., Bhat, T. N., Bluhm, W. F., Bourne, P. E., Burkhardt, K., Feng, Z., Gilliland, G. L., Iype, L., Jain, S., Fagan, P., Marvin, J., Padilla, D., Ravichandran, V., Schneider, B., Thanki, N., Weissig, H., Westbrook, J. D., & Zardecki, C. (2002). The Protein Data Bank. Acta Crystallographica Section D: Biological Crystallography, 58(Pt 6 No 1), 899\u2013907. https:\/\/doi.org\/10.1107\/S0907444902003451.","journal-title":"Acta Crystallographica Section D: Biological Crystallography"},{"issue":"D1","key":"1832_CR35","doi-asserted-by":"publisher","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","volume":"49","author":"S Kim","year":"2021","unstructured":"Kim, S., Chen, J., Cheng, T., Gindulyte, A., He, J., He, S., Li, Q., Shoemaker, B. A., Thiessen, P. A., Yu, B., Zaslavsky, L., Zhang, J., & Bolton, E. E. (2021). PubChem in 2021: New data content and improved web interfaces. Nucleic Acids Research, 49(D1), D1388\u2013D1395. https:\/\/doi.org\/10.1093\/nar\/gkaa971.","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"1832_CR36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"W Humphrey","year":"1996","unstructured":"Humphrey, W., Dalke, A., & Schulten, K. (1996). VMD: Visual molecular dynamics. Journal of Molecular Graphics, 14(1), 33\u201338. https:\/\/doi.org\/10.1016\/0263-7855(96)00018-5.","journal-title":"Journal of Molecular Graphics"},{"issue":"16","key":"1832_CR37","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"JC Phillips","year":"2005","unstructured":"Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kale, L., & Schulten, K. (2005). Scalable molecular dynamics with NAMD. Journal of Computational Chemistry, 26(16), 1781\u20131802. https:\/\/doi.org\/10.1002\/jcc.20289.","journal-title":"Journal of Computational Chemistry"},{"issue":"1","key":"1832_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nmeth.4067","volume":"14","author":"J Huang","year":"2017","unstructured":"Huang, J., Rauscher, S., Nawrocki, G., Belov, D., F\u00f6rster, J., Qin, M., & MacKerell, Jr., A. D. (2017). CHARMM36m: An improved force field for folded and intrinsically disordered proteins. Nature Methods, 14(1), 71\u201373. https:\/\/doi.org\/10.1038\/nmeth.4067.","journal-title":"Nature Methods"},{"issue":"7","key":"1832_CR39","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1021\/ct400341p","volume":"9","author":"DR Roe","year":"2013","unstructured":"Roe, D. R., & Cheatham, T. E. (2013). PTRAJ and CPPTRAJ: Software for processing and analysis of molecular dynamics trajectory data. Journal of Chemical Theory and Computation, 9(7), 3084\u20133095. https:\/\/doi.org\/10.1021\/ct400341p.","journal-title":"Journal of Chemical Theory and Computation"},{"issue":"7","key":"1832_CR40","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1021\/ci500020m","volume":"54","author":"R Kumari","year":"2014","unstructured":"Kumari, R., Kumar, R., Open Source Drug Discovery Consortium, & Lynn, A. (2014). g_mmpbsa\u2014A GROMACS tool for high-throughput MM-PBSA calculations. Journal of Chemical Information and Modeling, 54(7), 1951\u20131962. https:\/\/doi.org\/10.1021\/ci500020m.","journal-title":"Journal of Chemical Information and Modeling"},{"key":"1832_CR41","doi-asserted-by":"publisher","first-page":"952520","DOI":"10.3389\/fnins.2022.952520","volume":"16","author":"Y Tan","year":"2022","unstructured":"Tan, Y., Ma, S., Wang, Y., Ma, L., Song, J., Luo, X., & Huang, Y. (2022). Network pharmacology and molecular docking reveal the neuroprotective mechanism of ligustilide against Alzheimer\u2019s disease. Frontiers in Neuroscience, 16, 952520 https:\/\/doi.org\/10.3389\/fnins.2022.952520.","journal-title":"Frontiers in Neuroscience"},{"issue":"2","key":"1832_CR42","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pharep.2014.09.004","volume":"67","author":"A Kumar","year":"2015","unstructured":"Kumar, A., Singh, A., & Ekavali (2015). A review on Alzheimer\u2019s disease pathophysiology and its management: An update. Pharmacological Reports, 67(2), 195\u2013203. https:\/\/doi.org\/10.1016\/j.pharep.2014.09.004.","journal-title":"Pharmacological Reports"},{"issue":"4","key":"1832_CR43","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","volume":"14","author":"MT Heneka","year":"2015","unstructured":"Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., Herrup, K., Frautschy, S. A., Finsen, B., Brown, G. C., Verkhratsky, A., Yamanaka, K., Koistinaho, J., Latz, E., Halle, A., & Kummer, M. P. (2015). Neuroinflammation in Alzheimer\u2019s disease. The Lancet Neurology, 14(4), 388\u2013405. https:\/\/doi.org\/10.1016\/S1474-4422(15)70016-5.","journal-title":"The Lancet Neurology"},{"issue":"1","key":"1832_CR44","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s12035-014-8653-6","volume":"50","author":"PK Kamat","year":"2014","unstructured":"Kamat, P. K., Rai, S., Swarnkar, S., Shukla, R., & Nath, C. (2014). Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer\u2019s disease: Understanding the therapeutics strategies. Molecular Neurobiology, 50(1), 36\u201349. https:\/\/doi.org\/10.1007\/s12035-014-8653-6.","journal-title":"Molecular Neurobiology"},{"issue":"7","key":"1832_CR45","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sj.bjc.6603671","volume":"96","author":"M Yaar","year":"2007","unstructured":"Yaar, M., & Gilchrest, B. A. (2007). Ageing and cancer: The role of telomeres and telomerase. British Journal of Cancer, 96(7), 1028\u20131033. https:\/\/doi.org\/10.1038\/sj.bjc.6603671.","journal-title":"British Journal of Cancer"},{"key":"1832_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110277","volume":"128","author":"CP Chen","year":"2020","unstructured":"Chen, C. P., Hsu, Y. L., Chen, C. Y., Chuang, J. H., & Liu, C. C. (2020). Therapeutic potential of apigenin against Alzheimer\u2019s disease: Insights from pharmacological perspectives. Biomedicine & Pharmacotherapy, 128, 110277 https:\/\/doi.org\/10.1016\/j.biopha.2020.110277.","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"11","key":"1832_CR47","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1021\/ci300367a","volume":"52","author":"F Cheng","year":"2012","unstructured":"Cheng, F., Li, W., Zhou, Y., Shen, J., Wu, Z., Liu, G., Lee, P. W., & Tang, Y. (2012). admetSAR: A comprehensive source and free tool for assessment of chemical ADMET properties. Journal of Chemical Information and Modeling, 52(11), 3099\u20133105. https:\/\/doi.org\/10.1021\/ci300367a.","journal-title":"Journal of Chemical Information and Modeling"},{"issue":"6","key":"1832_CR48","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/bioinformatics\/bty707","volume":"35","author":"H Yang","year":"2019","unstructured":"Yang, H., Lou, C., Sun, L., Li, J., Cai, Y., Wang, Z., Li, W., Liu, G., & Tang, Y. (2019). admetSAR 2.0: Web-service for prediction and optimization of chemical ADMET properties. Bioinformatics, 35(6), 1067\u20131069. https:\/\/doi.org\/10.1093\/bioinformatics\/bty707.","journal-title":"Bioinformatics"},{"key":"1832_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7, 42717 https:\/\/doi.org\/10.1038\/srep42717.","journal-title":"Scientific Reports"},{"issue":"1","key":"1832_CR50","doi-asserted-by":"publisher","DOI":"10.1007\/s40203-021-00110-0","volume":"9","author":"VS Patil","year":"2021","unstructured":"Patil, V. S., Meena, H., & Harish, D. R. (2021). Erythrina variegata L. bark: an untapped bioactive source harbouring therapeutic properties for the treatment of Alzheimer\u2019s disease. In Silico Pharmacology, 9(1), 51.","journal-title":"In Silico Pharmacology"},{"key":"1832_CR51","doi-asserted-by":"publisher","first-page":"5519292","DOI":"10.1155\/2021\/5519292","volume":"2021","author":"Y Gao","year":"2021","unstructured":"Gao, Y., Wang, Y., Ma, Y., Yang, X., & Zhao, Y. (2021). Network pharmacology and molecular docking reveal the mechanism of the Shunaoxin pill in Alzheimer\u2019s disease. Evidence-Based Complementary and Alternative Medicine, 2021, 5519292 https:\/\/doi.org\/10.1155\/2021\/5519292.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"D1","key":"1832_CR52","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk, D., Gable, A. L., Lyon, D., Junge, A., Wyder, S., Huerta-Cepas, J., Simonovic, M., Doncheva, N. T., Morris, J. H., Bork, P., Jensen, L. J., & Mering, C. V. (2019). STRING v11: Protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Research, 47(D1), D607\u2013D613. https:\/\/doi.org\/10.1093\/nar\/gky1131.","journal-title":"Nucleic Acids Research"},{"key":"1832_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138335","volume":"730","author":"MS Uddin","year":"2020","unstructured":"Uddin, M. S., Kabir, M. T., Tewari, D., Mathew, B., Aleya, L., & Abdel-Daim, M. M. (2020). Exploring the promise of flavonoids to combat aging-associated neurodegeneration. Science of the Total Environment, 730, 138335 https:\/\/doi.org\/10.1016\/j.scitotenv.2020.138335.","journal-title":"Science of the Total Environment"},{"issue":"5","key":"1832_CR54","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.3390\/nu12051321","volume":"12","author":"H Khan","year":"2020","unstructured":"Khan, H., Ullah, H., Martorell, M., Valdes, S. E., Belwal, T., Tejada, S., Sureda, A., & Barreto, G. E. (2020). Flavonoids nanoparticles in cancer: Treatment modalities and associated challenges. Nutrients, 12(5), 1321 https:\/\/doi.org\/10.3390\/nu12051321.","journal-title":"Nutrients"},{"key":"1832_CR55","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.redox.2017.10.007","volume":"14","author":"JR Frandsen","year":"2018","unstructured":"Frandsen, J. R., & Narayanasamy, P. (2018). Neuroprotection through flavonoid: Enhancement of the glyoxalase pathway. Redox Biology, 14, 465\u2013473. https:\/\/doi.org\/10.1016\/j.redox.2017.10.007.","journal-title":"Redox Biology"},{"issue":"3","key":"1832_CR56","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M. T., Wang, S., Liu, H., & Yin, Y. (2016). Quercetin, inflammation and immunity. Nutrients, 8(3), 167 https:\/\/doi.org\/10.3390\/nu8030167.","journal-title":"Nutrients"},{"issue":"4","key":"1832_CR57","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1039\/B714182N","volume":"38","author":"JP Spencer","year":"2009","unstructured":"Spencer, J. P. (2009). The impact of flavonoids on memory: Physiological and molecular considerations. Chemical Society Reviews, 38(4), 1152\u20131161. https:\/\/doi.org\/10.1039\/B714182N.","journal-title":"Chemical Society Reviews"},{"issue":"2","key":"1832_CR58","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jep.2012.07.005","volume":"143","author":"F Dajas","year":"2012","unstructured":"Dajas, F. (2012). Life or death: Neuroprotective and anticancer effects of quercetin. Journal of Ethnopharmacology, 143(2), 383\u2013396. https:\/\/doi.org\/10.1016\/j.jep.2012.07.005.","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"1832_CR59","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1007\/s12035-014-8804-2","volume":"51","author":"SF Nabavi","year":"2015","unstructured":"Nabavi, S. F., Sureda, A., Daglia, M., Nabavi, S. M., & Bishayee, A. (2015). Targeting of the Nrf2 signaling pathway by polyphenols: A novel approach for neuroprotection. Molecular Neurobiology, 51(3), 1170\u20131178. https:\/\/doi.org\/10.1007\/s12035-014-8804-2.","journal-title":"Molecular Neurobiology"},{"key":"1832_CR60","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pneurobio.2013.11.003","volume":"111","author":"MS Tan","year":"2014","unstructured":"Tan, M. S., Yu, J. T., Tan, L., & Wang, H. F. (2014). Autophagy in aging and neurodegenerative diseases: Pathogenesis and therapeutic strategies. Progress in Neurobiology, 111, 79\u2013101. https:\/\/doi.org\/10.1016\/j.pneurobio.2013.11.003.","journal-title":"Progress in Neurobiology"},{"issue":"12","key":"1832_CR61","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.3390\/molecules24122277","volume":"24","author":"M Imran","year":"2019","unstructured":"Imran, M., Salehi, B., Sharifi-Rad, J., Aslam Gondal, T., Saeed, F., Imran, A., Shahbaz, M., Khan, M. A., & Capanoglu, E. (2019). Kaempferol: A key emphasis to its anticancer potential. Molecules, 24(12), 2277 https:\/\/doi.org\/10.3390\/molecules24122277.","journal-title":"Molecules"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01832-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01832-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01832-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T04:51:54Z","timestamp":1764910314000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01832-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":61,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1832"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01832-0","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,19]]},"assertion":[{"value":"8 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experiments on AD activity were carried out under the protocol MPh\/NC0220004\/KLECoPH\/21, which was approved by the Institutional Animal Ethics Committee (IAEC) of the Committee for Control and Supervision of Experiments on Animals (CCSEA), Govt. of India.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}