{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:15:54Z","timestamp":1772928954513,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01884-2","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:59:40Z","timestamp":1757408380000},"page":"663-682","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated In Vivo, In Vitro, and In Silico Evaluation of Spermacoce ocymoides Methanolic Extract for Antidiarrheal, Thrombolytic, and Antiarthritic Activities"],"prefix":"10.1007","volume":"84","author":[{"given":"Bakul","family":"Akter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kutub Uddin","family":"Ahamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Hossain","family":"Sohrab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Aishee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bidhan","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afra","family":"Anika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Kamrul","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan M.","family":"Alharbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad Rashad","family":"Sindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Most. Nazmin","family":"Aktar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"1884_CR1","doi-asserted-by":"publisher","first-page":"4586318","DOI":"10.1155\/2022\/4586318","volume":"2022","author":"AJ Chakraborty","year":"2022","unstructured":"Chakraborty, A. J., Uddin, T. M., Matin Zidan, B., Mitra, S., Das, R., Nainu, F., Dhama, K., Roy, A., Hossain, M. J., Khusro, A., & Emran, T. B. (2022). Allium cepa: A treasure of bioactive phytochemicals with prospective health benefits. Evidence-Based Complementary and Alternative Medicine, 2022, 4586318 https:\/\/doi.org\/10.1155\/2022\/4586318.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"1","key":"1884_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z","volume":"18","author":"EG Tse","year":"2019","unstructured":"Tse, E. G., Korsik, M., & Todd, M. H. (2019). The past, present and future of anti-malarial medicines. Malaria Journal, 18(1), 93 https:\/\/doi.org\/10.1186\/s12936-019-2724-z.","journal-title":"Malaria Journal"},{"issue":"3","key":"1884_CR3","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1021\/ar500400w","volume":"48","author":"JE Sears","year":"2015","unstructured":"Sears, J. E., & Boger, D. L. (2015). Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure\u2013function properties. Accounts of Chemical Research, 48(3), 653\u2013662. https:\/\/doi.org\/10.1021\/ar500400w.","journal-title":"Accounts of Chemical Research"},{"issue":"2","key":"1884_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.janh.2017.02.001","volume":"3","author":"K Brook","year":"2017","unstructured":"Brook, K., Bennett, J., & Desai, S. P. (2017). The chemical history of morphine: An 8000-year journey, from resin to de-novo synthesis. Journal of Anesthesia History, 3(2), 50\u201355. https:\/\/doi.org\/10.1016\/j.janh.2017.02.001.","journal-title":"Journal of Anesthesia History"},{"key":"1884_CR5","doi-asserted-by":"publisher","first-page":"892265","DOI":"10.3389\/fmed.2022.892265","volume":"9","author":"C Do","year":"2022","unstructured":"Do, C., Evans, G. J., DeAguero, J., Escobar, G. P., Lin, H. C., & Wagner, B. (2022). Dysnatremia in gastrointestinal disorders. Frontiers Media S.A., 9, 892265 https:\/\/doi.org\/10.3389\/fmed.2022.892265.","journal-title":"Frontiers Media S.A."},{"issue":"1","key":"1884_CR6","doi-asserted-by":"publisher","first-page":"3037120","DOI":"10.1155\/2018\/3037120","volume":"2018","author":"B Mekonnen","year":"2018","unstructured":"Mekonnen, B., Asrie, A. B., & Wubneh, Z. B. (2018). Antidiarrheal activity of 80% methanolic leaf extract of Justicia schimperiana. Evidence-Based Complementary and Alternative Medicine, 2018(1), 3037120 https:\/\/doi.org\/10.1155\/2018\/3037120.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"3","key":"1884_CR7","doi-asserted-by":"publisher","first-page":"234","DOI":"10.7861\/CLINMED2023-0076","volume":"23","author":"J Schofield","year":"2023","unstructured":"Schofield, J., & Toh, C. H. (2023). How to approach acute thrombosis and thrombocytopenia. Clinical Medicine, 23(3), 234\u2013241. https:\/\/doi.org\/10.7861\/CLINMED2023-0076.","journal-title":"Clinical Medicine"},{"issue":"1","key":"1884_CR8","doi-asserted-by":"publisher","first-page":"41","DOI":"10.5958\/2231-5659.2021.00007.2","volume":"11","author":"V Patel","year":"2021","unstructured":"Patel, V., Manek, R. A., & Sheth, D. B. (2021). Evaluation of in-vitro thrombolytic activity of methanolic extract of Prunus avium L. Asian Journal of Research in Pharmaceutical Science, 11(1), 41\u201344. https:\/\/doi.org\/10.5958\/2231-5659.2021.00007.2.","journal-title":"Asian Journal of Research in Pharmaceutical Science"},{"issue":"Suppl 2","key":"1884_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0049-3848(14)50009-6","volume":"133","author":"PW Kamphuisen","year":"2014","unstructured":"Kamphuisen, P. W., & Beyer-Westendorf, J. (2014). Bleeding complications during anticoagulant treatment in patients with cancer. Thrombosis Research, 133(Suppl 2), 2\u201355. https:\/\/doi.org\/10.1016\/S0049-3848(14)50009-6.","journal-title":"Thrombosis Research"},{"issue":"18","key":"1884_CR10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1056\/NEJM199005033221805","volume":"322","author":"FH Epstein","year":"1990","unstructured":"Epstein, F. H., & Harris, E. D. (1990). Rheumatoid arthritis. New England Journal of Medicine, 322(18), 1277\u20131289. https:\/\/doi.org\/10.1056\/NEJM199005033221805.","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"1884_CR11","doi-asserted-by":"publisher","first-page":"821","DOI":"10.18433\/J3VW2F","volume":"16","author":"S Harirforoosh","year":"2013","unstructured":"Harirforoosh, S., Asghar, W., & Jamali, F. (2013). Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. Journal of Pharmacy & Pharmaceutical Sciences, 16(5), 821\u2013847. https:\/\/doi.org\/10.18433\/J3VW2F.","journal-title":"Journal of Pharmacy & Pharmaceutical Sciences"},{"issue":"5","key":"1884_CR12","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s11101-019-09629-9","volume":"19","author":"I S\u00fcntar","year":"2020","unstructured":"S\u00fcntar, I. (2020). Importance of ethnopharmacological studies in drug discovery: role of medicinal plants. Phytochemistry Reviews, 19(5), 1199\u20131209. https:\/\/doi.org\/10.1007\/s11101-019-09629-9.","journal-title":"Phytochemistry Reviews"},{"issue":"2","key":"1884_CR13","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.jep.2013.12.017","volume":"151","author":"H Bhatia","year":"2014","unstructured":"Bhatia, H., Sharma, Y. P., Manhas, R. K., & Kumar, K. (2014). Ethnomedicinal plants used by the villagers of district Udhampur, J&K, India. Journal of ethnopharmacology, 151(2), 1005\u20131018. https:\/\/doi.org\/10.1016\/j.jep.2013.12.017.","journal-title":"Journal of ethnopharmacology"},{"key":"1884_CR14","unstructured":"Uddin, M. S., Sajid, M., Howlader, A., & Uddin, S. B. (2015). Three new records of dicotyledonous plants from Bangladesh, from www.tropicalplantresearch.com"},{"issue":"11","key":"1884_CR15","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4103\/0973-7847.95866","volume":"6","author":"LM Conserva","year":"2012","unstructured":"Conserva, L. M., & Ferreira, J. C. (2012). Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities. Pharmacognosy Reviews, 6(11), 46\u201355. https:\/\/doi.org\/10.4103\/0973-7847.95866.","journal-title":"Pharmacognosy Reviews"},{"issue":"08","key":"1884_CR16","first-page":"94","volume":"1","author":"S Shanmugam","year":"2011","unstructured":"Shanmugam, S., Annadurai, M., & Rajendran, K. (2011). Ethnomedicinal plants used to cure diarrhoea and dysentery in Pachalur hills of Dindigul district in Tamil Nadu, southern India. Journal of Applied Pharmaceutical Science, 1(08), 94\u201397.","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"1884_CR17","doi-asserted-by":"publisher","unstructured":"C. Okwuosa, D. Nwachukwu, P. Achukwu, C. Ezeorah, & A. Eze, Anti-ulcer activity of the leaf extracts of Borreria ocymoides in rats, Biological Research, 7(1), 2009, https:\/\/doi.org\/10.4314\/br.v7i1.45471.","DOI":"10.4314\/br.v7i1.45471"},{"issue":"1","key":"1884_CR18","first-page":"78","volume":"10","author":"O Oluwayemi","year":"2012","unstructured":"Oluwayemi, O., & Funmilayo, A. (2012). Preliminary studies on phytochemical and antimicrobial investigation of plants (Irawo-ile) Mitracarpus villosus, Euphorbia Hirta and Spermacoce Ocymoides. International Journal of Research 10(1), 78-81","journal-title":"International Journal of Research"},{"key":"1884_CR19","unstructured":"Ayyanar, M. (2009). Herbal medicines for wound healing among tribal people in Southern India: Ethnobotanical and scientific evidences, from http:\/\/www.healthy-synergies.com"},{"key":"1884_CR20","first-page":"100","volume":"1","author":"PK Parhi","year":"2012","unstructured":"Parhi, P. K., & Mohapatra, P. (2012). In-vitro anthelmintic activty of galenicals OF Spermacoce ocymoides (Burm F) DC. European Journal of Experimental Biology, 1, 100\u2013106.","journal-title":"European Journal of Experimental Biology"},{"issue":"4","key":"1884_CR21","doi-asserted-by":"publisher","first-page":"534","DOI":"10.5530\/PJ.2017.4.86","volume":"9","author":"SA Adesegun","year":"2017","unstructured":"Adesegun, S. A., Orabueze, C. I., & Babatunde Coker, H. A. (2017). Antimalarial and antioxidant potentials of extract and fractions of aerial part of Borreria ocymoides DC (Rubiaceae). Polymer Journal, 9(4), 534\u2013540. https:\/\/doi.org\/10.5530\/PJ.2017.4.86.","journal-title":"Polymer Journal"},{"key":"1884_CR22","doi-asserted-by":"publisher","unstructured":"Prieto-Mart\u00ednez, F. D., L\u00f3pez-L\u00f3pez, E., Ju\u00e1rez-Mercado, K. E., & Medina-Franco, J. L. (2019). Computational drug design methods\u2014current and future perspectives. In silico drug design, 19\u201344 https:\/\/doi.org\/10.1016\/B978-0-12-816125-8.00002-X.","DOI":"10.1016\/B978-0-12-816125-8.00002-X"},{"key":"1884_CR23","doi-asserted-by":"publisher","first-page":"125922","DOI":"10.1016\/j.biortech.2021.125922","volume":"342","author":"M L\u00f3pez-Rodr\u00edguez","year":"2021","unstructured":"L\u00f3pez-Rodr\u00edguez, M., Cer\u00f3n-Garc\u00eda, M. C., L\u00f3pez-Rosales, L., Navarro-L\u00f3pez, E., S\u00e1nchez Mir\u00f3n, A., Molina-Miras, A., Abreu, A. C., Fern\u00e1ndez, I., & Garc\u00eda-Camacho, F. (2021). An integrated approach for the efficient separation of specialty compounds from biomass of the marine microalgae Amphidinium carterae. Bioresource Technology, 342, 125922 https:\/\/doi.org\/10.1016\/j.biortech.2021.125922.","journal-title":"Bioresource Technology"},{"issue":"8","key":"1884_CR24","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.arabjc.2015.01.013","volume":"11","author":"N Akhtar","year":"2018","unstructured":"Akhtar, N., Haq, I. U., & Mirza, B. (2018). Phytochemical analysis and comprehensive evaluation of antimicrobial and antioxidant properties of 61 medicinal plant species. Arabian Journal of Chemistry, 11(8), 1223\u20131235. https:\/\/doi.org\/10.1016\/j.arabjc.2015.01.013.","journal-title":"Arabian Journal of Chemistry"},{"issue":"4","key":"1884_CR25","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nprot.2007.102","volume":"2","author":"EA Ainsworth","year":"2007","unstructured":"Ainsworth, E. A., & Gillespie, K. M. (2007). Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin\u2013Ciocalteu reagent. Nature protocols, 2(4), 875\u2013877. https:\/\/doi.org\/10.1038\/nprot.2007.102.","journal-title":"Nature protocols"},{"key":"1884_CR26","doi-asserted-by":"publisher","first-page":"111932","DOI":"10.1016\/j.lwt.2021.111932","volume":"150","author":"AM Shraim","year":"2021","unstructured":"Shraim, A. M., Ahmed, T. A., Rahman, M. M., & Hijji, Y. M. (2021). Determination of total flavonoid content by aluminum chloride assay: A critical evaluation. LWT, 150, 111932 https:\/\/doi.org\/10.1016\/j.lwt.2021.111932.","journal-title":"LWT"},{"issue":"4","key":"1884_CR27","doi-asserted-by":"publisher","first-page":"960","DOI":"10.3390\/plants12040960","volume":"12","author":"NA Baeshen","year":"2023","unstructured":"Baeshen, N. A., Almulaiky, Y. Q., Afifi, M., Al-Farga, A., Ali, H. A., Baeshen, N. N., Abomughaid, M. M., Abdelazim, A. M., & Baeshen, M. N. (2023). GC-MS Analysis of bioactive compounds extracted from plant Rhazya stricta using various solvents. Plants, 12(4), 960 https:\/\/doi.org\/10.3390\/plants12040960.","journal-title":"Plants"},{"issue":"4","key":"1884_CR28","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.joad.2016.05.002","volume":"5","author":"B Lawal","year":"2016","unstructured":"Lawal, B., Shittu, O. K., Oibiokpa, F. I., Mohammed, H., Umar, S. I., & Haruna, G. M. (2016). Antimicrobial evaluation, acute and sub-acute toxicity studies of Allium sativum. Journal of Acute Disease, 5(4), 296\u2013301. https:\/\/doi.org\/10.1016\/j.joad.2016.05.002.","journal-title":"Journal of Acute Disease"},{"key":"1884_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15058","volume":"8","author":"WX Yan","year":"2017","unstructured":"Yan, W. X., Mirzazadeh, R., Garnerone, S., Scott, D., Schneider, M. W., Kallas, T., Custodio, J., Wernersson, E., Li, Y., Gao, L., Federova, Y., Zetsche, B., Zhang, F., Bienko, M., & Crosetto, N. (2017). BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks. Nature Communications, 8, 15058 https:\/\/doi.org\/10.1038\/ncomms15058.","journal-title":"Nature Communications"},{"issue":"1","key":"1884_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-021-00541-7","volume":"23","author":"Y-Y Zhang","year":"2022","unstructured":"Zhang, Y.-Y., Huang, Y.-F., Liang, J., & Zhou, H. (2022). Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method. BMC Pharmacology and Toxicology, 23(1), 3 https:\/\/doi.org\/10.1186\/s40360-021-00541-7.","journal-title":"BMC Pharmacology and Toxicology"},{"key":"1884_CR31","doi-asserted-by":"publisher","unstructured":"M. Jhansi Rani, V. Hari Bhaskar, K. Bannoth Chandra Sekhar, & C. Author, Pharmacognostic and phytopharmaceutical studies of alocasia fornicata and its anti-diarrheal effect on castor oil induced diarrhea in rats, IOSR Journal Of Pharmacy And Biological Sciences, 16(1), 20\u201334, https:\/\/doi.org\/10.9790\/3008-1601052034.","DOI":"10.9790\/3008-1601052034"},{"issue":"1","key":"1884_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-460","volume":"14","author":"TT Tadesse","year":"2014","unstructured":"Tadesse, T. T., Hailu, E. E., Gurmu, E. E., & Mechesso, F. F. (2014). Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice. BMC Complementary and Alternative Medicine, 14(1), 460 https:\/\/doi.org\/10.1186\/1472-6882-14-460.","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"1","key":"1884_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-4-14","volume":"4","author":"S Prasad","year":"2006","unstructured":"Prasad, S., Kashyap, R. S., Deopujari, J. Y., Purohit, H. J., Taori, G. M., & Daginawala, H. F. (2006). Development of an in vitro model to study clot lysis activity of thrombolytic drugs. Thrombosis Journal, 4(1), 14 https:\/\/doi.org\/10.1186\/1477-9560-4-14.","journal-title":"Thrombosis Journal"},{"issue":"1","key":"1884_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0643-2","volume":"15","author":"TB Emran","year":"2015","unstructured":"Emran, T. B., Rahman, M. A., Uddin, M. M., Rahman, M. M., Uddin, M. Z., Dash, R., & Layzu, C. (2015). Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis. BMC Complementary and Alternative Medicine, 15(1), 128 https:\/\/doi.org\/10.1186\/s12906-015-0643-2.","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"1","key":"1884_CR35","doi-asserted-by":"publisher","first-page":"253","DOI":"10.36721\/PJPS.2022.35.1.SUP.253-257.1","volume":"35","author":"NH Alotaibi","year":"2022","unstructured":"Alotaibi, N. H., Sarwar, M., Alamgeer, Jabbar, Z., Munir, M. U., Irfan, H. M., Akram, M., Abbas Bukhari, S. N., Rasul Niazi, Z., & Khan, A. Q. (2022). Pharmacological exploration of anti-arthritic potential of terbutaline through in-vitro and in-vivo experimental models. Pakistan Journal of Pharmaceutical Sciences, 35(1), 253\u2013257. https:\/\/doi.org\/10.36721\/PJPS.2022.35.1.SUP.253-257.1.","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"issue":"1","key":"1884_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1879-9","volume":"17","author":"AM Alamgeer","year":"2017","unstructured":"Alamgeer, A. M., Uttra, & Hasan, U. H. (2017). Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch. BMC Complementary and Alternative Medicine, 17(1), 371 https:\/\/doi.org\/10.1186\/s12906-017-1879-9.","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"1","key":"1884_CR37","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1119\/1.19375","volume":"68","author":"N Argaman","year":"2000","unstructured":"Argaman, N., & Makov, G. (2000). Density functional theory: An introduction. American Journal of Physics, 68(1), 69\u201379. https:\/\/doi.org\/10.1119\/1.19375.","journal-title":"American Journal of Physics"},{"issue":"1","key":"1884_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14889-7","volume":"11","author":"T Che","year":"2020","unstructured":"Che, T., English, J., Krumm, B. E., Kim, K., Pardon, E., Olsen, R., Wang, S., Zhang, S., Diberto, J. F., Sciaky, N., Carroll, F. I., Steyaert, J., Wacker, D., & Roth, B. L. (2020). Nanobody-enabled monitoring of kappa opioid receptor states. Nature Communications, 11(1), 1145 https:\/\/doi.org\/10.1038\/s41467-020-14889-7.","journal-title":"Nature Communications"},{"issue":"35","key":"1884_CR39","doi-asserted-by":"publisher","first-page":"21713","DOI":"10.1074\/jbc.272.35.21713","volume":"272","author":"M Renatus","year":"1997","unstructured":"Renatus, M., Bode, W., Huber, R., St\u00fcrzebecher, J., Prasa, D., Fischer, S., Kohnert, U., & Stubbs, M. T. (1997). Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Journal of Biological Chemistry, 272(35), 21713\u201321719. https:\/\/doi.org\/10.1074\/jbc.272.35.21713.","journal-title":"Journal of Biological Chemistry"},{"issue":"6782","key":"1884_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/35011103","volume":"405","author":"JR Kiefer","year":"2000","unstructured":"Kiefer, J. R., Pawlitz, J. L., Moreland, K. T., Stegeman, R. A., Hood, W. F., Gierse, J. K., Stevens, A. M., Goodwin, D. C., Rowlinson, S. W., Marnett, L. J., Stallings, W. C., & Kurumbail, R. G. (2000). Structural insights into the stereochemistry of the cyclooxygenase reaction. Nature, 405(6782), 97\u2013101. https:\/\/doi.org\/10.1038\/35011103.","journal-title":"Nature"},{"key":"1884_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7, 42717 https:\/\/doi.org\/10.1038\/srep42717.","journal-title":"Scientific Reports"},{"issue":"8","key":"1884_CR42","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/bioinformatics\/16.8.747","volume":"16","author":"A Lagunin","year":"2000","unstructured":"Lagunin, A., Stepanchikova, A., Filimonov, D., & Poroikov, V. (2000). PASS: Prediction of activity spectra for biologically active substances. Bioinformatics, 16(8), 747\u2013748. https:\/\/doi.org\/10.1093\/bioinformatics\/16.8.747.","journal-title":"Bioinformatics"},{"issue":"1","key":"1884_CR43","doi-asserted-by":"publisher","first-page":"12702","DOI":"10.1016\/j.heliyon.2022.e12702","volume":"9","author":"AA Muzahid","year":"2023","unstructured":"Muzahid, A. A., Sharmin, S., Hossain, M. S., Ahamed, K. U., Ahmed, N., Yeasmin, M. S., Ahmed, N. U., Saha, B. K., Rana, G., Maitra, B., & Bhuiyan, M. (2023). Analysis of bioactive compounds present in different crude extracts of Benincasa hispida and Cucurbita moschata seeds by gas chromatography-mass spectrometry. Heliyon, 9(1), 12702 https:\/\/doi.org\/10.1016\/j.heliyon.2022.e12702.","journal-title":"Heliyon"},{"issue":"1","key":"1884_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1625-3","volume":"17","author":"M Sisay","year":"2017","unstructured":"Sisay, M., Engidawork, E., & Shibeshi, W. (2017). Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model. BMC Complementary and Alternative Medicine, 17(1), 103 https:\/\/doi.org\/10.1186\/s12906-017-1625-3.","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"8","key":"1884_CR45","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/0024-3205(87)90677-1","volume":"41","author":"IM Coupar","year":"1987","unstructured":"Coupar, I. M. (1987). Opioid action on the intestine: The importance of the intestinal mucosa. Life Sciences, 41(8), 917\u2013925. https:\/\/doi.org\/10.1016\/0024-3205(87)90677-1.","journal-title":"Life Sciences"},{"issue":"17","key":"1884_CR46","doi-asserted-by":"publisher","first-page":"5377","DOI":"10.3390\/molecules26175377","volume":"26","author":"MC Dias","year":"2021","unstructured":"Dias, M. C., Pinto, D. C. G. A., & Silva, A. M. S. (2021). Plant flavonoids: Chemical characteristics and biological activity. Molecules, 26(17), 5377 https:\/\/doi.org\/10.3390\/molecules26175377.","journal-title":"Molecules"},{"key":"1884_CR47","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jep.2019.03.019","volume":"237","author":"AM Uttra","year":"2019","unstructured":"Uttra, A. M., Alamgeer, Shahzad, M., Shabbir, A., Jahan, S., Bukhari, I. A., & Assiri, A. M. (2019). Ribes orientale: A novel therapeutic approach targeting rheumatoid arthritis with reference to pro-inflammatory cytokines, inflammatory enzymes and anti-inflammatory cytokines. Journal of Ethnopharmacology, 237, 92\u2013107. https:\/\/doi.org\/10.1016\/j.jep.2019.03.019.","journal-title":"Journal of Ethnopharmacology"},{"key":"1884_CR48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","volume":"6","author":"Q Guo","year":"2018","unstructured":"Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N. J., & Xu, J. (2018). Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Research, 6, 15 https:\/\/doi.org\/10.1038\/s41413-018-0016-9.","journal-title":"Bone Research"},{"key":"1884_CR49","doi-asserted-by":"publisher","first-page":"2515260","DOI":"10.1155\/2022\/2515260","volume":"2022","author":"S Islam","year":"2022","unstructured":"Islam, S., Fahad, F. I., Sultana, A., Sayem, S., Roy, S. B., Islam, M. N., Roy, A., & Sayeed, M. A. (2022). Evaluation of antioxidant, cytotoxic, anti-inflammatory, antiarthritic, thrombolytic, and anthelmintic activity of methanol extract of lepidagathis hyalina nees root. Evidence-Based Complementary and Alternative Medicine, 2022, 2515260 https:\/\/doi.org\/10.1155\/2022\/2515260.","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"1","key":"1884_CR50","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1515\/jbcpp-2016-0023","volume":"28","author":"P Ansari","year":"2017","unstructured":"Ansari, P., Uddin, M. J., Rahman, M. M., Abdullah-Al-Mamun, M., Islam, M. R., Ali, M. H., & Reza, A. S. (2017). Anti-inflammatory, anti-diarrheal, thrombolytic and cytotoxic activities of an ornamental medicinal plant: Persicaria orientalis. Journal of Basic and Clinical Physiology and Pharmacology, 28(1), 51\u201358. https:\/\/doi.org\/10.1515\/jbcpp-2016-0023.","journal-title":"Journal of Basic and Clinical Physiology and Pharmacology"},{"key":"1884_CR51","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.comptc.2013.02.020","volume":"1012","author":"M Targema","year":"2013","unstructured":"Targema, M., Obi-Egbedi, N. O., & Adeoye, M. D. (2013). Molecular structure and solvent effects on the dipole moments and polarizabilities of some aniline derivatives. Computational and Theoretical Chemistry, 1012, 47\u201353. https:\/\/doi.org\/10.1016\/j.comptc.2013.02.020.","journal-title":"Computational and Theoretical Chemistry"},{"issue":"10","key":"1884_CR52","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1039\/c2sc20731a","volume":"3","author":"BC Popere","year":"2012","unstructured":"Popere, B. C., Della Pelle, A. M., Poe, A., Balaji, G., & Thayumanavan, S. (2012). Predictably tuning the frontier molecular orbital energy levels of panchromatic low band gap BODIPY-based conjugated polymers. Chemical Science, 3(10), 3093 https:\/\/doi.org\/10.1039\/c2sc20731a.","journal-title":"Chemical Science"},{"issue":"4","key":"1884_CR53","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/J.JBIOSC.2014.03.004","volume":"118","author":"JH Choi","year":"2014","unstructured":"Choi, J. H., Kim, D. W., Park, S. E., Choi, B. S., Sapkota, K., Kim, S., & Kim, S. J. (2014). Novel thrombolytic protease from edible and medicinal plant Aster yomena (Kitam.) Honda with anticoagulant activity: Purification and partial characterization. Journal of Bioscience and Bioengineering, 118(4), 372\u2013377. https:\/\/doi.org\/10.1016\/J.JBIOSC.2014.03.004.","journal-title":"Journal of Bioscience and Bioengineering"},{"issue":"1","key":"1884_CR54","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.fuel.2008.07.027","volume":"88","author":"W Geng","year":"2009","unstructured":"Geng, W., Nakajima, T., Takanashi, H., & Ohki, A. (2009). Analysis of carboxyl group in coal and coal aromaticity by Fourier transform infrared (FT-IR) spectrometry. Fuel, 88(1), 139\u2013144. https:\/\/doi.org\/10.1016\/j.fuel.2008.07.027.","journal-title":"Fuel"},{"key":"1884_CR55","doi-asserted-by":"publisher","first-page":"euw091","DOI":"10.1093\/europace\/euw091","volume":"19","author":"J Wang","year":"2016","unstructured":"Wang, J., Wang, G., Quan, X., Ruan, L., Liu, Y., Ruan, Y., Liu, N., Zhang, C., & Bai, R. (2016). Fluconazole-induced long QT syndrome via impaired human ether-a-go-go-related gene (hERG) protein trafficking in rabbits. Europace, 19, euw091\u2013euw1249. https:\/\/doi.org\/10.1093\/europace\/euw091.","journal-title":"Europace"},{"issue":"12","key":"1884_CR56","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1080\/17460441.2020.1798926","volume":"15","author":"S Kar","year":"2020","unstructured":"Kar, S., & Leszczynski, J. (2020). Open access in silico tools to predict the ADMET profiling of drug candidates. Expert opinion on drug discovery, 15(12), 1473.  https:\/\/doi.org\/10.1080\/17460441.2020.1798926.","journal-title":"Cell Biochemistry and Biophysics"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01884-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01884-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:48:13Z","timestamp":1772858893000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01884-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["1884"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01884-2","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"31 August 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}