{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:04:01Z","timestamp":1790201041609,"version":"4.1.0"},"reference-count":154,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01929-6","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:17:48Z","timestamp":1761895068000},"page":"341-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Revolutionizing Breast Cancer Treatment: Harnessing Ehrlich Ascites Carcinoma Model, Cancer Metabolism, and Nanotechnology-Enhanced Chemotherapy for Improved Patient Outcomes"],"prefix":"10.1007","volume":"84","author":[{"given":"Amira T.","family":"Khattab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai M.","family":"El-Keey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doha M.","family":"Beltagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-6932","authenticated-orcid":false,"given":"Maha M.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"1929_CR1","unstructured":"Milano, E. (2025). ID4-dependent reprogramming of tumor associated macrophages in triple negative breast cancer. Universit\u00e0 degli Studi di Roma \u201cLa Sapienza.\u201d. https:\/\/tesidottorato.depositolegale.it\/handle\/20.500.14242\/95566"},{"issue":"1","key":"1929_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-025-03767-1","volume":"25","author":"H Pang","year":"2025","unstructured":"Pang, H. & Badehnoosh, B. Synergistic strength: unleashing exercise and polyphenols against breast cancer. Cancer Cell Int, 25(1), 144, https:\/\/doi.org\/10.1186\/s12935-025-03767-1 (2025).","journal-title":"Cancer Cell Int"},{"issue":"20","key":"1929_CR3","doi-asserted-by":"publisher","first-page":"14017","DOI":"10.1039\/D4RA02639J","volume":"14","author":"SL Mugundhan","year":"2024","unstructured":"Mugundhan, S. L. & Mohan, M. Nanoscale strides: exploring innovative therapies for breast cancer treatment. RSC Adv, 14(20), 14017\u201340 (2024).","journal-title":"RSC Adv"},{"issue":"2","key":"1929_CR4","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1245\/s10434-024-16454-8","volume":"32","author":"J Pang","year":"2025","unstructured":"Pang, J., Ding, N., Liu, X., He, X., Zhou, W. & Xie, H. et al. Prognostic value of the baseline systemic immune-inflammation index in HER2-positive metastatic breast cancer: Exploratory analysis of two prospective trials. Ann Surg Oncol, 32(2), 750\u20139, https:\/\/doi.org\/10.1245\/s10434-024-16454-8 (2025).","journal-title":"Ann Surg Oncol"},{"issue":"13","key":"1929_CR5","doi-asserted-by":"publisher","first-page":"7208","DOI":"10.3390\/ijms25137208","volume":"25","author":"L Yang","year":"2024","unstructured":"Yang, L., Hu, Q. & Huang, T. Breast cancer treatment strategies targeting the tumor microenvironment: How to convert \u201ccold\u201d tumors to \u201chot\u201d tumors. Int J Mol Sci, 25(13), 7208, https:\/\/doi.org\/10.3390\/ijms25137208 (2024).","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1929_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3390\/biomedinformatics5030046","volume":"5","author":"MA Rahman","year":"2025","unstructured":"Rahman, M. A., Khan, M. S. H., Watanobe, Y., Prioty, J. T., Annita, T. T. & Rahman, S. et al. Advancements in breast cancer detection: A review of global trends, risk factors, imaging modalities, machine learning, and deep learning approaches. BioMedInformatics, 5(3), 46, https:\/\/doi.org\/10.3390\/biomedinformatics5030046 (2025).","journal-title":"BioMedInformatics"},{"issue":"1","key":"1929_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12672-025-01884-x","volume":"16","author":"M Shokoohi","year":"2025","unstructured":"Shokoohi, M., Sedaghatshoar, S., Arian, H., Mokarami, M., Habibi, F. & Bamarinejad, F. Genetic advancements in breast cancer treatment: a review. Discov Oncol, 16(1), 127, https:\/\/doi.org\/10.1007\/s12672-025-01884-x (2025).","journal-title":"Discov Oncol"},{"issue":"8","key":"1929_CR8","doi-asserted-by":"publisher","first-page":"7326","DOI":"10.1007\/s12144-025-07443-5","volume":"44","author":"MK Jamal","year":"2025","unstructured":"Jamal, M. K., Moghadam, F. R., Muhammadamin Malkari, B. H., Meshkvat, M., Rastgou, P. & Moghimi, S. et al. Factors influencing the quality of life of postpartum women: a systematic review. Curr Psychol, 44(8), 7326\u201349, https:\/\/doi.org\/10.1007\/s12144-025-07443-5 (2025).","journal-title":"Curr Psychol"},{"key":"1929_CR9","doi-asserted-by":"publisher","unstructured":"Ribeiro. H. F., Pelloso, F. C., da Fonseca, B. S., Camparoto, C. W., Carvalho, M., & Marques, V. D., et al. (2025). Racial and socioeconomic disparity in breast cancer mortality: A systematic review and meta-analysis. Cancers, 17. https:\/\/doi.org\/10.3390\/cancers17101641","DOI":"10.3390\/cancers17101641"},{"key":"1929_CR10","doi-asserted-by":"publisher","unstructured":"Hawazie, A, & Druce, M. (2025). Breast cancer risk and management in the endocrine clinic: A comprehensive review. Clinical Endocrinology, 4. https:\/\/doi.org\/10.1111\/cen.15209","DOI":"10.1111\/cen.15209"},{"issue":"6","key":"1929_CR11","doi-asserted-by":"publisher","first-page":"e0318079","DOI":"10.1371\/journal.pone.0318079","volume":"20","author":"MA Shaon","year":"2025","unstructured":"Shaon, M. A., Ansari, F., Mahmud, Z., Tamanna, S., Ibrahim, M. N. B. & Alam, N. F. et al. Aldo-keto reductase family 1 member C3 (AKR1C3) gene polymorphism (rs12529) is associated with breast cancer in Bangladeshi population: A case-control study and computational investigation. PLoS One, 20(6), e0318079, https:\/\/doi.org\/10.1371\/journal.pone.0318079 (2025).","journal-title":"PLoS One"},{"issue":"7","key":"1929_CR12","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.31557\/APJCP.2025.26.7.2445","volume":"26","author":"P Manatunga","year":"2025","unstructured":"Manatunga, P., & Kuruppu D. C. (2025). Breast cancer awareness, attitudes, and practices among non-medical female undergraduates in Sri Lanka: Implications for health education and early detection strategies. Asian Pacific Journal of Cancer Prevention, 26(7), 2445\u20132454. https:\/\/journal.waocp.org\/article_91746_44fa6287b72a20077301e494e2b05f34.pdf","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"5","key":"1929_CR13","doi-asserted-by":"publisher","first-page":"051701","DOI":"10.3788\/col202018.051701","volume":"18","author":"X Ma","year":"2020","unstructured":"Ma, X., Cheng, H., Hou, J., Jia, Z., Wu, G. & L\u00fc, X. Y. et al. Detection of breast cancer based on novel porous silicon Bragg reflector surface-enhanced Raman spectroscopy-active structure. Chin Opt Lett, 18(5), 051701, https:\/\/doi.org\/10.3788\/col202018.051701 (2020).","journal-title":"Chin Opt Lett"},{"issue":"1","key":"1929_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","volume":"10","author":"X Xiong","year":"2025","unstructured":"Xiong, X., Zheng, L. W., Ding, Y., Chen, Y. F., Cai, Y. W. & Wang, L. P. et al. Breast cancer: pathogenesis and treatments. Signal Transduct Target Ther, 10(1), 49, https:\/\/doi.org\/10.1038\/s41392-024-02108-4 (2025).","journal-title":"Signal Transduct Target Ther"},{"key":"1929_CR15","doi-asserted-by":"publisher","unstructured":"Brown, S. R., & Vomhof-DeKrey, E. E. (2024). Current immunotherapy treatments of primary breast cancer subtypes. Biomedicines, 12(4). https:\/\/doi.org\/10.3390\/biomedicines12040895","DOI":"10.3390\/biomedicines12040895"},{"key":"1929_CR16","doi-asserted-by":"publisher","first-page":"322","DOI":"10.20892\/j.issn.2095-3941.2024.0510","volume":"22","author":"J Bai","year":"2025","unstructured":"Bai, J., Gao, Y. & Zhang, G. The treatment of breast cancer in the era of precision medicine. Cancer Biol Med, 22, 322\u201347, https:\/\/doi.org\/10.20892\/j.issn.2095-3941.2024.0510 (2025).","journal-title":"Cancer Biol Med"},{"issue":"1","key":"1929_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/10815589241283515","volume":"73","author":"OC Ioachimescu","year":"2025","unstructured":"Ioachimescu, O. C. & Shaker, R. Translational science and related disciplines. J Investig Med, 73(1), 3\u201326, https:\/\/doi.org\/10.1177\/10815589241283515 (2025).","journal-title":"J Investig Med"},{"issue":"2","key":"1929_CR18","doi-asserted-by":"publisher","first-page":"e1230","DOI":"10.1002\/cl2.1230","volume":"18","author":"NR Haddaway","year":"2022","unstructured":"Haddaway, N. R., Page, M. J., Pritchard, C. C. & McGuinness, L. A. PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev., 18(2), e1230, https:\/\/doi.org\/10.1002\/cl2.1230 (2022).","journal-title":"Campbell Syst Rev."},{"issue":"10","key":"1929_CR19","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.3390\/ijms26104572","volume":"26","author":"A Ciringione","year":"2025","unstructured":"Ciringione, A. & Rizzi, F. Facing the challenge to mimic breast cancer heterogeneity: Established and emerging experimental preclinical models integrated with omics technologies. Int J Mol Sci, 26(10), 4572, https:\/\/doi.org\/10.3390\/ijms26104572 (2025).","journal-title":"Int J Mol Sci"},{"key":"1929_CR20","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.sajb.2024.08.044","volume":"174","author":"E Kilickaya Selvi","year":"2024","unstructured":"Kilickaya Selvi, E. & Unal, G. The anticancer activity of Cuscuta campestris Yunck extract: An combined study of in vitro and in vivo experiments. S Afr J Bot, 174, 40\u20138, https:\/\/doi.org\/10.1016\/j.sajb.2024.08.044 (2024).","journal-title":"S Afr J Bot"},{"issue":"5","key":"1929_CR21","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1093\/jleuko\/qiae013","volume":"115","author":"K Mahanti","year":"2024","unstructured":"Mahanti, K., Saha, J., Sarkar, D., Pramanik, A., Roy Chattopadhyay, N. & Bhattacharyya, S. Alteration of functionality and differentiation directed by changing gene expression patterns in myeloid-derived suppressor cells (MDSCs) in tumor microenvironment and bone marrow through early to terminal phase of tumor progression. J Leukoc Biol, 115(5), 958\u201384, https:\/\/doi.org\/10.1093\/jleuko\/qiae013 (2024).","journal-title":"J Leukoc Biol"},{"issue":"5","key":"1929_CR22","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1208\/s12249-025-03107-6","volume":"26","author":"AK Lunawat","year":"2025","unstructured":"Lunawat, A. K., Mukherjee, D., Shivgotra, R., Raikwar, S., Awasthi, A. & Singh, A. et al. Carboplatin co-loaded 5-fluorouracil nanoparticles conjugated with trastuzumab for targeted therapy in HER2+ heterogeneity breast cancer. AAPS PharmSciTech, 26(5), 114, https:\/\/doi.org\/10.1208\/s12249-025-03107-6 (2025).","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"1929_CR23","doi-asserted-by":"publisher","first-page":"142","DOI":"10.21608\/djs.2024.310411.1180","volume":"48","author":"MM Elwan","year":"2024","unstructured":"Elwan, M. M., Elserafy, M. A., Elborady, O. M., Massoud, A. & Aboushafei, A. The potential therapeutic effect of loaded ginger nanoparticles against Ehrlich ascites carcinoma (EAC) bearing mice-induced renal toxicity. Delta Journal of Science, 48(2), 142\u201360, https:\/\/doi.org\/10.21608\/djs.2024.310411.1180 (2024).","journal-title":"Delta Journal of Science"},{"issue":"4","key":"1929_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02669-6","volume":"42","author":"NI Giritlioglu","year":"2025","unstructured":"Giritlioglu, N. I., Poyraz, F. S., Mansuroglu, B. & Erisen, S. Cost-effective isolation of Viburnum opulus-derived nanovesicles and evaluation of their cytotoxic, anticancer, and antioxidant properties on human glioblastoma cell line U87MG. Med Oncol, 42(4), 112, https:\/\/doi.org\/10.1007\/s12032-025-02669-6 (2025).","journal-title":"Med Oncol"},{"issue":"43","key":"1929_CR25","doi-asserted-by":"publisher","first-page":"20131","DOI":"10.1039\/d4nr02365j","volume":"16","author":"P Gupta","year":"2024","unstructured":"Gupta, P., Bansal, A., Kaur, H., Anees, M., Singh, N. & Singh, H. Folic acid-targeted redox responsive polylactic acid-based nanoparticles co-delivering pirarubicin and salinomycin suppress breast cancer tumor growth in vivo. Nanoscale, 16(43), 20131\u201346, https:\/\/doi.org\/10.1039\/d4nr02365j (2024).","journal-title":"Nanoscale"},{"issue":"25","key":"1929_CR26","doi-asserted-by":"publisher","first-page":"20143","DOI":"10.1039\/D5RA01014D","volume":"15","author":"M El Behery","year":"2025","unstructured":"El Behery, M., Abo-Elmatty, D. M., Alsunbul, M., Mohey El-Deen, Y. I., Mohamed, D. I. & Rashad Sindi, E. et al. Exploration of the anticancer efficacy of a novel 1,3-thiazole analog in an ehrlich ascites carcinoma model: in vivo and in silico insights into hepatorenal protective potentials via the modulation of apoptosis, oxidative stress and inflammation. RSC Adv, 15(25), 20143\u201367, https:\/\/doi.org\/10.1039\/D5RA01014D (2025).","journal-title":"RSC Adv"},{"issue":"16","key":"1929_CR27","doi-asserted-by":"publisher","first-page":"8041","DOI":"10.3390\/ijms26168041","volume":"26","author":"MK Piera\u0144ski","year":"2025","unstructured":"Piera\u0144ski, M. K., Kaniowski, D. & Szweda, P. Therapeutic potential of Propolis in preclinical models of cancer and infectious diseases: A review. Int J Mol Sci, 26(16), 8041, https:\/\/doi.org\/10.3390\/ijms26168041 (2025).","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1929_CR28","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1007\/s11696-025-04007-6","volume":"79","author":"C Selvaraj","year":"2025","unstructured":"Selvaraj, C., Santhosh, R., Alothaim, A. S., Vijayakumar, R., Desai, D. & Safi, S. Z. et al. Advances in cancer therapy: unveil the immunomodulatory protein involved in signaling pathways as molecular targets. Chem Pap, 79(6), 3493\u2013511, https:\/\/doi.org\/10.1007\/s11696-025-04007-6 (2025).","journal-title":"Chem Pap"},{"key":"1929_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-025-00779-x","volume":"13","author":"X Liu","year":"2025","unstructured":"Liu, X., Zhang, J., Yi, T., Li, H., Tang, X. & Liu, D. et al. Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies. Biomark Res., 13, 62, https:\/\/doi.org\/10.1186\/s40364-025-00779-x (2025).","journal-title":"Biomark Res."},{"issue":"10","key":"1929_CR30","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1111\/bph.16232","volume":"182","author":"X Lu","year":"2025","unstructured":"Lu, X., Friedrich, L. J. & Efferth, T. Natural products targeting tumour angiogenesis. Br J Pharmacol, 182(10), 2094\u2013136, https:\/\/doi.org\/10.1111\/bph.16232 (2025).","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1929_CR31","doi-asserted-by":"publisher","first-page":"2535787","DOI":"10.1080\/21645515.2025.2535787","volume":"21","author":"I Owliaee","year":"2025","unstructured":"Owliaee, I., Shoushtari, M., Karimi, Z. & Shojaeian, A. Natural carrier systems in cancer vaccines and immunotherapy. Hum Vaccin Immunother, 21(1), 2535787, https:\/\/doi.org\/10.1080\/21645515.2025.2535787 (2025).","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"1929_CR32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00395-024-01090-w","volume":"120","author":"J Brauer","year":"2025","unstructured":"Brauer, J., Tumani, M., Frey, N. & Lehmann, L. H. The cardio-oncologic burden of breast cancer: molecular mechanisms and importance of preclinical models. Basic Res Cardiol, 120(1), 91\u2013112, https:\/\/doi.org\/10.1007\/s00395-024-01090-w (2025).","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"1929_CR33","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s43556-025-00261-y","volume":"6","author":"X Dai","year":"2025","unstructured":"Dai, X., Xi, M. & Li, J. Cancer metastasis: molecular mechanisms and therapeutic interventions. Mol Biomed, 6(1), 20, https:\/\/doi.org\/10.1186\/s43556-025-00261-y (2025).","journal-title":"Mol Biomed"},{"issue":"1","key":"1929_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3390\/cancers17010155","volume":"17","author":"R Clay","year":"2025","unstructured":"Clay, R., Li, K. & Jin, L. Metabolic signaling in the tumor microenvironment. Cancers (Basel), 17(1), 155, https:\/\/doi.org\/10.3390\/cancers17010155 (2025).","journal-title":"Cancers (Basel)"},{"key":"1929_CR35","doi-asserted-by":"publisher","first-page":"1484686","DOI":"10.3389\/fimmu.2025.1484686","volume":"16","author":"H Li","year":"2025","unstructured":"Li, H., Shan, C., Zhu, Y., Yao, X., Lin, L. & Zhang, X. et al. Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications. Front Immunol, 16, 1484686, https:\/\/doi.org\/10.3389\/fimmu.2025.1484686 (2025).","journal-title":"Front Immunol"},{"issue":"5","key":"1929_CR36","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.3390\/ijms26051967","volume":"26","author":"Z Frost","year":"2025","unstructured":"Frost, Z., Bakhit, S., Amaefuna, C. N., Powers, R. V. & Ramana, K. V. Recent advances on the role of B vitamins in cancer prevention and progression. Int J Mol Sci, 26(5), 1967, https:\/\/doi.org\/10.3390\/ijms26051967 (2025).","journal-title":"Int J Mol Sci"},{"issue":"11","key":"1929_CR37","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.7150\/thno.107812","volume":"15","author":"Z Zhang","year":"2025","unstructured":"Zhang, Z., Tang, S., Qi, M., Zhao, H., Wu, M. & Huang, S. W. Mitochondria-targeting natural product rhein conjugated with dichloroacetate as the dual inhibitor of glycolysis and oxidative phosphorylation to off energize cancer cells and induce ROS storm. Theranostics, 15(11), 4909\u201329, https:\/\/doi.org\/10.7150\/thno.107812 (2025).","journal-title":"Theranostics"},{"issue":"1","key":"1929_CR38","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13287-025-04218-4","volume":"16","author":"C Zhang","year":"2025","unstructured":"Zhang, C., Xu, S., Yin, C., Hu, S. & Liu, P. The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials. Stem Cell Res Ther, 16(1), 156, https:\/\/doi.org\/10.1186\/s13287-025-04218-4 (2025).","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"1929_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53517-y","volume":"14","author":"AA Noser","year":"2024","unstructured":"Noser, A. A., El-Barbary, A. A., Salem, M. M., El Salam, H. A. A. & Shahien, M. Synthesis and molecular docking simulations of novel azepines based on quinazolinone moiety as prospective antimicrobial and antitumor hedgehog signaling inhibitors. Scientific Reports, 14(1), 3530, https:\/\/doi.org\/10.1038\/s41598-024-53517-y (2024).","journal-title":"Scientific Reports"},{"issue":"7","key":"1929_CR40","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.3390\/ijms26073279","volume":"26","author":"Y Salinas","year":"2025","unstructured":"Salinas, Y., Chauhan, S. C. & Bandyopadhyay, D. Small-molecule mitotic inhibitors as anticancer agents: Discovery, classification, mechanisms of action, and clinical trials. Int J Mol Sci, 26(7), 3279, https:\/\/doi.org\/10.3390\/ijms26073279 (2025).","journal-title":"Int J Mol Sci"},{"issue":"8","key":"1929_CR41","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.3390\/antiox12081597","volume":"12","author":"M Monroy-C\u00e1rdenas","year":"2023","unstructured":"Monroy-C\u00e1rdenas, M., Andrades, V., Almarza, C., Vera, M. J., Mart\u00ednez, J. & Pulgar, R. et al. A new quinone-based inhibitor of mitochondrial Complex I in D-conformation, producing invasion reduction and sensitization to venetoclax in breast cancer cells. Antioxidants (Basel), 12(8), 1597, https:\/\/doi.org\/10.3390\/antiox12081597 (2023).","journal-title":"Antioxidants (Basel)"},{"key":"1929_CR42","doi-asserted-by":"publisher","unstructured":"Zafar, A., Khatoon, S., Khan, M.J., Abu, J., & Naeem, A. (2025). Advancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy. Discover Oncology, 16(1). https:\/\/doi.org\/10.1007\/s12672-025-02198-8","DOI":"10.1007\/s12672-025-02198-8"},{"issue":"4","key":"1929_CR43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41388-024-03227-6","volume":"44","author":"A Jain","year":"2025","unstructured":"Jain, A., Barge, A. & Parris, C. N. Combination strategies with PARP inhibitors in BRCA-mutated triple-negative breast cancer: overcoming resistance mechanisms. Oncogene., 44(4), 193\u2013207, https:\/\/www.nature.com\/articles\/s41388-024-03227-6.pdf (2025).","journal-title":"Oncogene."},{"key":"1929_CR44","doi-asserted-by":"publisher","unstructured":"Haynes, J, & Manogaran, P. (2025). Mechanisms and strategies to overcome drug resistance in colorectal cancer. International Journal of Molecular, 26. https:\/\/doi.org\/10.3390\/ijms26051988","DOI":"10.3390\/ijms26051988"},{"issue":"1","key":"1929_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42137-7","volume":"13","author":"WM Hamada","year":"2023","unstructured":"Hamada, W. M., El-Nahass, M. N., Noser, A. A., Fayed, T. A., El-Kemary, M., Salem, M. M. & Bakr, E. A. Simple dihydropyridine-based colorimetric chemosensors for heavy metal ion detection, biological evaluation, molecular docking, and ADMET profiling. Scientific Reports, 13(1), 15420 (2023).","journal-title":"Scientific Reports"},{"issue":"25","key":"1929_CR46","doi-asserted-by":"publisher","first-page":"26762","DOI":"10.1021\/acsomega.4c00617","volume":"9","author":"N Bano","year":"2024","unstructured":"Bano, N., Parveen, S., Saeed, M., Siddiqui, S., Abohassan, M. & Mir, S. S. Drug repurposing of selected antibiotics: An emerging approach in cancer drug discovery. ACS Omega, 9(25), 26762\u201379, https:\/\/doi.org\/10.1021\/acsomega.4c00617 (2024).","journal-title":"ACS Omega"},{"issue":"10","key":"1929_CR47","doi-asserted-by":"publisher","first-page":"e70947","DOI":"10.1002\/cam4.70947","volume":"14","author":"I Attique","year":"2025","unstructured":"Attique, I., Haider, Z., Khan, M., Hassan, S., Soliman, M. M. & Ibrahim, W. N. et al. Reactive oxygen species: From tumorigenesis to therapeutic strategies in cancer. Cancer Med, 14(10), e70947, https:\/\/doi.org\/10.1002\/cam4.70947 (2025).","journal-title":"Cancer Med"},{"issue":"115722","key":"1929_CR48","doi-asserted-by":"publisher","first-page":"115722","DOI":"10.1016\/j.envres.2023.115722","volume":"227","author":"YQ Almajidi","year":"2023","unstructured":"Almajidi, Y. Q., Kadhim, M. M., Alsaikhan, F., Turki Jalil, A., Hassan Sayyid, N. & Alexis Ram\u00edrez-Coronel, A. et al. Doxorubicin-loaded micelles in tumor cell-specific chemotherapy. Environ Res, 227(115722), 115722, https:\/\/doi.org\/10.1016\/j.envres.2023.115722 (2023).","journal-title":"Environ Res"},{"key":"1929_CR49","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bioactmat.2022.12.010","volume":"24","author":"X Qu","year":"2023","unstructured":"Qu, X., Zhou, D., Lu, J., Qin, D., Zhou, J. & Liu, H. J. Cancer nanomedicine in preoperative therapeutics: Nanotechnology-enabled neoadjuvant chemotherapy, radiotherapy, immunotherapy, and phototherapy. Bioact Mater., 24, 136\u201352, https:\/\/doi.org\/10.1016\/j.bioactmat.2022.12.010 (2023).","journal-title":"Bioact Mater."},{"key":"1929_CR50","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1007\/s13346-024-01648-0","volume":"15","author":"A Bisht","year":"2025","unstructured":"Bisht, A., Avinash, D., Sahu, K. K., Patel, P., Das Gupta, G. & Kurmi, B. D. A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer. Drug Deliv Transl Res., 15, 102\u201333 (2025).","journal-title":"Drug Deliv Transl Res."},{"issue":"8","key":"1929_CR51","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/1120009X.2023.2300217","volume":"36","author":"MA Manavi","year":"2024","unstructured":"Manavi, M. A., Fathian Nasab, M. H., Mohammad Jafari, R. & Dehpour, A. R. Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents. J Chemother, 36(8), 623\u201353, https:\/\/doi.org\/10.1080\/1120009X.2023.2300217 (2024).","journal-title":"J Chemother"},{"key":"1929_CR52","doi-asserted-by":"publisher","unstructured":"Ingole, S., Vasdev, N., Tekade, M., Gupta, T., Pawar, B., & Mhatre, M., et al. (2024). Toxic effects of cancer therapies. In: Public health and toxicology issues drug research (pp. 353\u2013379). Elsevier. https:\/\/doi.org\/10.1016\/b978-0-443-15842-1.00004-1","DOI":"10.1016\/b978-0-443-15842-1.00004-1"},{"key":"1929_CR53","doi-asserted-by":"publisher","DOI":"10.1039\/d4cs00483c","author":"A Ressnerova","year":"2025","unstructured":"Ressnerova, A., Heger, Z. & Pumera, M. Translational nanorobotics breaking through biological membranes. Chem Soc Rev https:\/\/doi.org\/10.1039\/d4cs00483c (2025).","journal-title":"Chem Soc Rev"},{"issue":"1","key":"1929_CR54","doi-asserted-by":"publisher","first-page":"155","DOI":"10.7150\/thno.103376","volume":"15","author":"M Jiang","year":"2025","unstructured":"Jiang, M., Fang, H. & Tian, H. Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer. Theranostics, 15(1), 155\u201388, https:\/\/doi.org\/10.7150\/thno.103376 (2025).","journal-title":"Theranostics"},{"key":"1929_CR55","doi-asserted-by":"publisher","unstructured":"Sutkowy, P., & Czele\u0144, P. (2025). Redox balance in cancer in the context of tumor prevention and treatment. Biomedicines, 13. https:\/\/doi.org\/10.3390\/biomedicines13051149","DOI":"10.3390\/biomedicines13051149"},{"issue":"8","key":"1929_CR56","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41568-025-00824-9","volume":"25","author":"A Soragni","year":"2025","unstructured":"Soragni, A., Knudsen, E. S., O\u2019Connor, T. N., Tognon, C. E., Tyner, J. W. & Gini, B. et al. Acquired resistance in cancer: towards targeted therapeutic strategies. Nat Rev Cancer, 25(8), 613\u201333, https:\/\/doi.org\/10.1038\/s41568-025-00824-9 (2025).","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1929_CR57","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s43556-024-00239-2","volume":"6","author":"Y Gu","year":"2025","unstructured":"Gu, Y., Yang, R., Zhang, Y., Guo, M., Takehiro, K. & Zhan, M. et al. Molecular mechanisms and therapeutic strategies in overcoming chemotherapy resistance in cancer. Mol Biomed, 6(1), 2, https:\/\/doi.org\/10.1186\/s43556-024-00239-2 (2025).","journal-title":"Mol Biomed"},{"issue":"12","key":"1929_CR58","doi-asserted-by":"publisher","first-page":"115064","DOI":"10.1016\/j.celrep.2024.115064","volume":"43","author":"Y Mao","year":"2024","unstructured":"Mao, Y., Xia, Z., Xia, W. & Jiang, P. Metabolic reprogramming, sensing, and cancer therapy. Cell Rep, 43(12), 115064, https:\/\/doi.org\/10.1016\/j.celrep.2024.115064 (2024).","journal-title":"Cell Rep"},{"issue":"4","key":"1929_CR59","doi-asserted-by":"publisher","first-page":"C869","DOI":"10.1152\/ajpcell.00429.2024","volume":"327","author":"MG Rolver","year":"2024","unstructured":"Rolver, M. G., Severin, M. & Pedersen, S. F. Regulation of cancer cell lipid metabolism and oxidative phosphorylation by microenvironmental acidosis. Am J Physiol Cell Physiol, 327(4), C869\u201383, https:\/\/doi.org\/10.1152\/ajpcell.00429.2024 (2024).","journal-title":"Am J Physiol Cell Physiol"},{"issue":"10","key":"1929_CR60","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.3390\/cancers12102819","volume":"12","author":"RM Pascale","year":"2020","unstructured":"Pascale, R. M., Calvisi, D. F., Simile, M. M., Feo, C. F. & Feo, F. The Warburg effect 97 years after its discovery. Cancers (Basel), 12(10), 2819, https:\/\/doi.org\/10.3390\/cancers12102819 (2020).","journal-title":"Cancers (Basel)"},{"issue":"6","key":"1929_CR61","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.3390\/ijms25063142","volume":"25","author":"I Barba","year":"2024","unstructured":"Barba, I., Carrillo-Bosch, L. & Seoane, J. Targeting the Warburg effect in cancer: Where do we stand? Int J Mol Sci., 25(6), 3142, https:\/\/doi.org\/10.3390\/ijms25063142 (2024).","journal-title":"Int J Mol Sci."},{"issue":"3","key":"1929_CR62","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1021\/acsptsci.3c00301","volume":"7","author":"R Akter","year":"2024","unstructured":"Akter, R., Awais, M., Boopathi, V., Ahn, J. C., Yang, D. C. & Kang, S. C. et al. Inversion of the Warburg effect: Unraveling the metabolic nexus between obesity and cancer. ACS Pharmacol Transl Sci., 7(3), 560\u20139, https:\/\/doi.org\/10.1021\/acsptsci.3c00301 (2024).","journal-title":"ACS Pharmacol Transl Sci."},{"issue":"3","key":"1929_CR63","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/cancers16030504","volume":"16","author":"M Mathew","year":"2024","unstructured":"Mathew, M., Nguyen, N. T., Bhutia, Y. D., Sivaprakasam, S. & Ganapathy, V. Metabolic signature of Warburg effect in cancer: An effective and obligatory interplay between nutrient transporters and catabolic\/anabolic pathways to promote tumor growth. Cancers (Basel), 16(3), 504, https:\/\/doi.org\/10.3390\/cancers16030504 (2024).","journal-title":"Cancers (Basel)"},{"issue":"28","key":"1929_CR64","doi-asserted-by":"publisher","first-page":"e2308255","DOI":"10.1002\/advs.202308255","volume":"11","author":"S Confalonieri","year":"2024","unstructured":"Confalonieri, S., Matoskova, B., Pennisi, R., Martino, F., De Mario, A. & Miloro, G. et al. A PET-surrogate signature for the interrogation of the metabolic status of breast cancers. Adv Sci (Weinh), 11(28), e2308255, https:\/\/doi.org\/10.1002\/advs.202308255 (2024).","journal-title":"Adv Sci (Weinh)"},{"issue":"7","key":"1929_CR65","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3390\/metabo12070643","volume":"12","author":"R Subramani","year":"2022","unstructured":"Subramani, R., Poudel, S., Smith, K. D., Estrada, A. & Lakshmanaswamy, R. Metabolomics of breast cancer: A review. Metabolites, 12(7), 643, https:\/\/doi.org\/10.3390\/metabo12070643 (2022).","journal-title":"Metabolites"},{"issue":"1","key":"1929_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02165-x","volume":"23","author":"S Liu","year":"2024","unstructured":"Liu, S., Zhang, X., Wang, W., Li, X., Sun, X. & Zhao, Y. et al. Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer. Mol Cancer, 23(1), 261, https:\/\/doi.org\/10.1186\/s12943-024-02165-x (2024).","journal-title":"Mol Cancer"},{"key":"1929_CR67","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/s12276-025-01415-2","volume":"57","author":"S Park","year":"2025","unstructured":"Park, S. & Hall, M. N. Metabolic reprogramming in hepatocellular carcinoma: mechanisms and therapeutic implications. Exp Mol Med, 57, 515\u201323, https:\/\/doi.org\/10.1038\/s12276-025-01415-2 (2025).","journal-title":"Exp Mol Med"},{"key":"1929_CR68","doi-asserted-by":"publisher","unstructured":"Huang, X., Liu, B., & Shen, S. (2025). Lipid metabolism in breast cancer: From basic research to clinical application. Cancers, 17. https:\/\/doi.org\/10.3390\/cancers17040650","DOI":"10.3390\/cancers17040650"},{"issue":"1","key":"1929_CR69","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s12929-024-01013-w","volume":"31","author":"S Xu","year":"2024","unstructured":"Xu, S., Wang, L., Zhao, Y., Mo, T., Wang, B. & Lin, J. et al. Metabolism-regulating non-coding RNAs in breast cancer: roles, mechanisms and clinical applications. J Biomed Sci, 31(1), 25, https:\/\/doi.org\/10.1186\/s12929-024-01013-w (2024).","journal-title":"J Biomed Sci"},{"key":"1929_CR70","doi-asserted-by":"publisher","first-page":"117955492513317","DOI":"10.1177\/11795549251331755","volume":"19","author":"S Zhu","year":"2025","unstructured":"Zhu, S., Liu, Y., Chen, H., Zhu, X., Liu, X. & Xu, K. et al. Mechanism and therapeutic progress of one-carbon metabolic key enzyme: Serine hydroxymethyltransferase 2 in cancer. Clin Med Insights Oncol, 19, 11795549251331756, https:\/\/doi.org\/10.1177\/11795549251331755 (2025).","journal-title":"Clin Med Insights Oncol"},{"issue":"217977","key":"1929_CR71","doi-asserted-by":"publisher","first-page":"217977","DOI":"10.1016\/j.canlet.2025.217977","volume":"632","author":"HY Tsai","year":"2025","unstructured":"Tsai, H. Y., Chen, M. H., Yun, J., Lai, L. A., Valentine, J. F. & Bronner, M. P. et al. Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer. Cancer Lett, 632(217977), 217977, https:\/\/doi.org\/10.1016\/j.canlet.2025.217977 (2025).","journal-title":"Cancer Lett"},{"issue":"10","key":"1929_CR72","doi-asserted-by":"publisher","first-page":"e2415550","DOI":"10.1002\/adma.202415550","volume":"37","author":"J Shi","year":"2025","unstructured":"Shi, J., Han, W., Wang, J. & Kong, X. Anti-tumor strategies targeting nutritional deprivation: Challenges and opportunities. Adv Mater, 37(10), e2415550, https:\/\/doi.org\/10.1002\/adma.202415550 (2025).","journal-title":"Adv Mater"},{"issue":"1","key":"1929_CR73","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12929-025-01167-1","volume":"32","author":"BS Pan","year":"2025","unstructured":"Pan, B. S., Hsu, C. C., Wu, H. E., Chen, Y. R., Zhou, X. & Wang, S. C. et al. Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting. J Biomed Sci, 32(1), 71, https:\/\/doi.org\/10.1186\/s12929-025-01167-1 (2025).","journal-title":"J Biomed Sci"},{"key":"1929_CR74","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2024","author":"Y Peng-Winkler","year":"2025","unstructured":"Peng-Winkler, Y. & Fendt, S. M. Metabolic adaptations in cancer progression. Physiol Rev https:\/\/doi.org\/10.1152\/physrev.00037.2024 (2025).","journal-title":"Physiol Rev"},{"issue":"1","key":"1929_CR75","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/procel\/pwae052","volume":"16","author":"Z Jiang","year":"2025","unstructured":"Jiang, Z., Xiong, N., Yan, R., Li, S. T., Liu, H. & Mao, Q. et al. PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression. Protein Cell, 16(1), 49\u201363, https:\/\/doi.org\/10.1093\/procel\/pwae052 (2025).","journal-title":"Protein Cell"},{"issue":"15","key":"1929_CR76","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3390\/cells14151177","volume":"14","author":"M Cordani","year":"2025","unstructured":"Cordani, M., Rumio, C., Bontempi, G., Strippoli, R. & Marcucci, F. Oxidative and glycolytic metabolism: Their reciprocal regulation and dysregulation in cancer. Cells, 14(15), 1177, https:\/\/doi.org\/10.3390\/cells14151177 (2025).","journal-title":"Cells"},{"key":"1929_CR77","doi-asserted-by":"publisher","unstructured":"Li, Y., Zhang, H., Yu, C., Dong, X., Yang, F., & Wang, M, et al. (2024) . New insights into mitochondria in health and diseases. International Journal of Molecular Sciences, 25(18). https:\/\/doi.org\/10.3390\/ijms25189975","DOI":"10.3390\/ijms25189975"},{"issue":"7","key":"1929_CR78","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3390\/cells14070511","volume":"14","author":"NR Selvaraj","year":"2025","unstructured":"Selvaraj, N. R., Nandan, D., Nair, B. G., Nair, V. A., Venugopal, P. & Aradhya, R. Oxidative stress and redox imbalance: Common mechanisms in cancer stem cells and neurodegenerative diseases. Cells, 14(7), 511, https:\/\/doi.org\/10.3390\/cells14070511 (2025).","journal-title":"Cells"},{"issue":"11","key":"1929_CR79","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.3390\/biomedicines12112589","volume":"12","author":"I Paraskevaidis","year":"2024","unstructured":"Paraskevaidis, I., Kourek, C., Farmakis, D. & Tsougos, E. Heart failure: A deficiency of energy-A path yet to discover and walk. Biomedicines, 12(11), 2589, https:\/\/doi.org\/10.3390\/biomedicines12112589 (2024).","journal-title":"Biomedicines"},{"key":"1929_CR80","doi-asserted-by":"publisher","first-page":"1421905","DOI":"10.3389\/fphar.2024.1421905","volume":"15","author":"Y Yan","year":"2024","unstructured":"Yan, Y., Li, S., Su, L., Tang, X., Chen, X. & Gu, X. et al. Mitochondrial inhibitors: a new horizon in breast cancer therapy. Front Pharmacol, 15, 1421905, https:\/\/doi.org\/10.3389\/fphar.2024.1421905 (2024).","journal-title":"Front Pharmacol"},{"issue":"5","key":"1929_CR81","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.3390\/cimb46050282","volume":"46","author":"LV Bel\u2019skaya","year":"2024","unstructured":"Bel\u2019skaya, L. V. & Dyachenko, E. I. Oxidative stress in breast cancer: A biochemical map of reactive oxygen species production. Curr Issues Mol Biol, 46(5), 4646\u201387, https:\/\/doi.org\/10.3390\/cimb46050282 (2024).","journal-title":"Curr Issues Mol Biol"},{"key":"1929_CR82","doi-asserted-by":"publisher","first-page":"116008","DOI":"10.1016\/j.ejmech.2023.116008","volume":"264","author":"L Gan","year":"2024","unstructured":"Gan, L., Yang, Y., Liang, Z., Zhang, M., He, Y. & Zhang, S. L. Targeting the pyruvate dehydrogenase complex\/pyruvate dehydrogenase kinase (PDC\/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation. Eur J Med Chem, 264, 116008, https:\/\/doi.org\/10.1016\/j.ejmech.2023.116008 (2024).","journal-title":"Eur J Med Chem"},{"issue":"216924","key":"1929_CR83","doi-asserted-by":"publisher","first-page":"216924","DOI":"10.1016\/j.canlet.2024.216924","volume":"592","author":"D Xiong","year":"2024","unstructured":"Xiong, D., Wang, Q., Wang, W. M. & Sun, Z. J. Tuning cellular metabolism for cancer virotherapy. Cancer Lett, 592(216924), 216924, https:\/\/doi.org\/10.1016\/j.canlet.2024.216924 (2024).","journal-title":"Cancer Lett"},{"issue":"1","key":"1929_CR84","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62262-1","volume":"14","author":"Z Liang","year":"2024","unstructured":"Liang, Z., Ralph-Epps, T., Schmidtke, M. W., Lazcano, P., Denis, S. W. & Bal\u00e1\u017eov\u00e1, M. et al. Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells. Sci Rep, 14(1), 11497, https:\/\/doi.org\/10.1038\/s41598-024-62262-1 (2024).","journal-title":"Sci Rep"},{"issue":"1","key":"1929_CR85","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1146\/annurev-cancerbio-062822-120857","volume":"8","author":"AM Li","year":"2024","unstructured":"Li, A. M. & Ye, J. Deciphering the Warburg effect: Metabolic reprogramming, epigenetic remodeling, and cell dedifferentiation. Annu Rev Cancer Biol., 8(1), 35\u201358, https:\/\/doi.org\/10.1146\/annurev-cancerbio-062822-120857 (2024).","journal-title":"Annu Rev Cancer Biol."},{"key":"1929_CR86","first-page":"313","volume":"84","author":"C Bianchi","year":"2024","unstructured":"Bianchi, C., Martinelli, R. P., Rozados, V. R. & Scharovsky, O. G. Use of sodium dichloroacetate for cancer treatment: a scoping review. Medicina (B Aires)., 84, 313\u201323 (2024).","journal-title":"Medicina (B Aires)."},{"key":"1929_CR87","doi-asserted-by":"publisher","unstructured":"Hunt, S., Thyagarajan, A., & Sahu, R. P. (2025). Dichloroacetate and salinomycin as therapeutic agents in cancer. Medical Sciences, 13. https:\/\/doi.org\/10.3390\/medsci13020047","DOI":"10.3390\/medsci13020047"},{"issue":"6","key":"1929_CR88","doi-asserted-by":"publisher","first-page":"744","DOI":"10.3390\/ph17060744","volume":"17","author":"T Koltai","year":"2024","unstructured":"Koltai, T. & Fliegel, L. Dichloroacetate for cancer treatment: Some facts and many doubts. Pharmaceuticals (Basel), 17(6), 744, https:\/\/doi.org\/10.3390\/ph17060744 (2024).","journal-title":"Pharmaceuticals (Basel)"},{"key":"1929_CR89","doi-asserted-by":"publisher","first-page":"1254313","DOI":"10.3389\/fcell.2023.1254313","volume":"11","author":"KE Pendleton","year":"2023","unstructured":"Pendleton, K. E., Wang, K. & Echeverria, G. V. Rewiring of mitochondrial metabolism in therapy-resistant cancers: permanent and plastic adaptations. Front Cell Dev Biol, 11, 1254313, https:\/\/doi.org\/10.3389\/fcell.2023.1254313 (2023).","journal-title":"Front Cell Dev Biol"},{"issue":"1630279","key":"1929_CR90","doi-asserted-by":"publisher","first-page":"1630279","DOI":"10.3389\/fimmu.2025.1630279","volume":"16","author":"L Zhexian","year":"2025","unstructured":"Zhexian, L., Xingqi, G., Xinxin, D., Tong, X., Siping, M. & Yanxi, L. Clinical application prospects of traditional Chinese medicine as adjuvant therapy for metabolic reprogramming in colorectal cancer. Front Immunol, 16(1630279), 1630279, https:\/\/doi.org\/10.3389\/fimmu.2025.1630279 (2025).","journal-title":"Front Immunol"},{"key":"1929_CR91","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.freeradbiomed.2024.12.035","volume":"227","author":"M Benbelkacem","year":"2025","unstructured":"Benbelkacem, M., Moulai, N., Chader, H., Ouahioune, W. & Bourouba, M. Dichloroacetate and chloroquine in combination with arsenite suppress ROS-induced oral squamous cell carcinoma (OSCC) development and improve BALB\/c mice survival. Free Radic Biol Med, 227, 593\u2013607, https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.12.035 (2025).","journal-title":"Free Radic Biol Med"},{"issue":"13","key":"1929_CR92","doi-asserted-by":"publisher","first-page":"7314","DOI":"10.3390\/ijms25137314","volume":"25","author":"CMC Andr\u00e9s","year":"2024","unstructured":"Andr\u00e9s, C. M. C., P\u00e9rez de la Lastra, J. M., Bustamante Munguira, E., Andr\u00e9s Juan, C. & P\u00e9rez-Lebe\u00f1a, E. Anticancer activity of metallodrugs and metallizing host defense peptides-current developments in structure-activity relationship. Int J Mol Sci, 25(13), 7314, https:\/\/doi.org\/10.3390\/ijms25137314 (2024).","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1929_CR93","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s13105-025-01068-9","volume":"81","author":"M Zhou","year":"2025","unstructured":"Zhou, M., Qin, Z., Zhu, X., Ruan, Y., Ling, H. & Li, C. et al. Pyruvate dehydrogenase kinases: key regulators of cellular metabolism and therapeutic targets for metabolic diseases. J Physiol Biochem, 81(1), 21\u201334, https:\/\/doi.org\/10.1007\/s13105-025-01068-9 (2025).","journal-title":"J Physiol Biochem"},{"issue":"11","key":"1929_CR94","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1038\/s44321-024-00155-6","volume":"16","author":"L Nuyttens","year":"2024","unstructured":"Nuyttens, L., Vandewalle, J. & Libert, C. Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approaches. EMBO Mol Med, 16(11), 2678\u201398, https:\/\/doi.org\/10.1038\/s44321-024-00155-6 (2024).","journal-title":"EMBO Mol Med"},{"issue":"1","key":"1929_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/revic-2023-0007","volume":"44","author":"S De","year":"2024","unstructured":"De, S. & Nag, S. Homo and heterometallic ruthenium and platinum complexes with multiple targets for therapeutic applications: a review. Rev Inorg Chem, 44(1), 1\u201323, https:\/\/doi.org\/10.1515\/revic-2023-0007 (2024).","journal-title":"Rev Inorg Chem"},{"issue":"12","key":"1929_CR96","doi-asserted-by":"publisher","first-page":"e70709","DOI":"10.1096\/fj.202400230rr","volume":"39","author":"VS Bebarta","year":"2025","unstructured":"Bebarta, V. S. & Nath, A. K. Redirecting intermediary metabolism to counteract cyanide poisoning. FASEB J., 39(12), e70709, https:\/\/doi.org\/10.1096\/fj.202400230rr (2025).","journal-title":"FASEB J."},{"key":"1929_CR97","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.2147\/IJN.S513207","volume":"20","author":"K Jiang","year":"2025","unstructured":"Jiang, K., Liu, H., Chen, X., Wang, Z., Wang, X. & Gu, X. et al. Reprogramming of glucose metabolism by nanocarriers to improve cancer immunotherapy: Recent advances and applications. Int J Nanomedicine, 20, 4201\u201334, https:\/\/doi.org\/10.2147\/IJN.S513207 (2025).","journal-title":"Int J Nanomedicine"},{"issue":"14","key":"1929_CR98","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.3390\/cancers17142341","volume":"17","author":"A Dominiak","year":"2025","unstructured":"Dominiak, A., Che\u0142stowska, B. & Nowicka, G. Metabolic adaptations in cancer progression: Optimization strategies and therapeutic targets. Cancers (Basel), 17(14), 2341, https:\/\/doi.org\/10.3390\/cancers17142341 (2025).","journal-title":"Cancers (Basel)"},{"key":"1929_CR99","doi-asserted-by":"publisher","unstructured":"Tang, J,. Karbhari, N., & Campian, J. (2025). Therapeutic targets in glioblastoma: Molecular pathways, emerging strategies, and future directions. Cells, 14. https:\/\/doi.org\/10.3390\/cells14070494","DOI":"10.3390\/cells14070494"},{"issue":"1","key":"1929_CR100","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1080\/20415990.2024.2415281","volume":"16","author":"A Dhiman","year":"2025","unstructured":"Dhiman, A., Rana, D., Benival, D. & Garkhal, K. Comprehensive insights into glioblastoma multiforme: drug delivery challenges and multimodal treatment strategies. Ther Deliv, 16(1), 87\u2013115, https:\/\/doi.org\/10.1080\/20415990.2024.2415281 (2025).","journal-title":"Ther Deliv"},{"key":"1929_CR101","doi-asserted-by":"publisher","DOI":"10.1039\/d4cs00679h","author":"M Ma","year":"2024","unstructured":"Ma, M., Zhang, Y., Pu, K. & Tang, W. Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity. Chem Soc Rev https:\/\/doi.org\/10.1039\/d4cs00679h (2024).","journal-title":"Chem Soc Rev"},{"key":"1929_CR102","doi-asserted-by":"publisher","first-page":"1434137","DOI":"10.3389\/fphar.2024.1434137","volume":"15","author":"Y Tu","year":"2024","unstructured":"Tu, Y., Gong, J., Mou, J., Jiang, H., Zhao, H. & Gao, J. Strategies for the development of stimuli-responsive small molecule prodrugs for cancer treatment. Front Pharmacol, 15, 1434137, https:\/\/doi.org\/10.3389\/fphar.2024.1434137 (2024).","journal-title":"Front Pharmacol"},{"key":"1929_CR103","unstructured":"Ogunjobi, T. T., Nebolisa, N. M., & Ajayi, R. O. https:\/\/www.researchgate.net\/profile\/Morenikeji-Euba-2\/publication\/389320871_European_Journal_of_Sustainable_Development_Research_Novel_mechanism_for_protein_delivery_in_breast_cancer_therapy_A_public_health_perspective_Citation\/links\/67be4ccef5cb8f70d5c00594\/European-Journal-of-Sustainable-Development-Research-Novel-mechanism-for-protein-delivery-in-breast-cancer-therapy-A-public-health-perspective-Citation.pdf"},{"key":"1929_CR104","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.2147\/ijn.s466042","volume":"19","author":"Y Wang","year":"2024","unstructured":"Wang, Y., Xu, Y., Song, J., Liu, X., Liu, S. & Yang, N. et al. Tumor cell-targeting and tumor microenvironment-responsive nanoplatforms for the multimodal imaging-guided photodynamic\/photothermal\/chemodynamic treatment of cervical cancer. Int J Nanomedicine, 19, 5837\u201358, https:\/\/doi.org\/10.2147\/ijn.s466042 (2024).","journal-title":"Int J Nanomedicine"},{"issue":"103263","key":"1929_CR105","doi-asserted-by":"publisher","first-page":"103263","DOI":"10.1016\/j.cis.2024.103263","volume":"332","author":"TT Truong","year":"2024","unstructured":"Truong, T. T., Mondal, S., Doan, V. H. M., Tak, S., Choi, J. & Oh, H. et al. Precision-engineered metal and metal-oxide nanoparticles for biomedical imaging and healthcare applications. Adv Colloid Interface Sci, 332(103263), 103263, https:\/\/doi.org\/10.1016\/j.cis.2024.103263 (2024).","journal-title":"Adv Colloid Interface Sci"},{"key":"1929_CR106","doi-asserted-by":"publisher","first-page":"102332","DOI":"10.1016\/j.tice.2024.102332","volume":"87","author":"FM El-Demerdash","year":"2024","unstructured":"El-Demerdash, F. M., Al Mhanna, A. B., El-Sayed, R. A., Mohamed, T. M. & Salem, M. M. Hepatoprotective impact of Nigella sativa silver nanocomposite against genotoxicity, oxidative stress, and inflammation induced by thioacetamide. Tissue and Cell, 87, 102332, https:\/\/doi.org\/10.1016\/j.tice.2024.102332 (2024).","journal-title":"Tissue and Cell"},{"key":"1929_CR107","doi-asserted-by":"publisher","unstructured":"Rahman, M. A., Jalouli, M., Yadab M., & Al-Zharani, M. (2025). Progress in drug delivery systems based on nanoparticles for improved glioblastoma therapy: Addressing challenges and investigating opportunities. Cancers, 17. https:\/\/doi.org\/10.3390\/cancers17040701","DOI":"10.3390\/cancers17040701"},{"key":"1929_CR108","doi-asserted-by":"publisher","unstructured":"Yuan, H., Chen, Y., Hu, Y., Li, Y., Zhang, H., & Zhang, S., et al. (2025). Disulfide bond-driven nanoassembly of lipophilic epirubicin prodrugs for breast cancer therapy. Journal of Pharmaceutical Investigation. https:\/\/doi.org\/10.1007\/s40005-025-00731-z","DOI":"10.1007\/s40005-025-00731-z"},{"issue":"51","key":"1929_CR109","doi-asserted-by":"publisher","first-page":"48625","DOI":"10.1021\/acsomega.3c07345","volume":"8","author":"M Rahman","year":"2023","unstructured":"Rahman, M., Afzal, O., Ullah, S. N. M. N., Alshahrani, M. Y., Alkhathami, A. G. & Altamimi, A. S. A. et al. Nanomedicine-based drug-targeting in breast cancer: Pharmacokinetics, clinical progress, and challenges. ACS Omega, 8(51), 48625\u201349, https:\/\/doi.org\/10.1021\/acsomega.3c07345 (2023).","journal-title":"ACS Omega"},{"issue":"6","key":"1929_CR110","doi-asserted-by":"publisher","first-page":"6369","DOI":"10.1007\/s00210-024-03764-7","volume":"398","author":"MS Abdelhamid","year":"2025","unstructured":"Abdelhamid, M. S., Wadan, A. H. S., Saad, H. A., El-Dakroury, W. A., Hageen, A. W. & Mohammed, D. H. et al. Nanoparticle innovations in targeted cancer therapy: advancements in antibody-drug conjugates. Naunyn Schmiedebergs Arch Pharmacol, 398(6), 6369\u201389, https:\/\/doi.org\/10.1007\/s00210-024-03764-7 (2025).","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1929_CR111","doi-asserted-by":"publisher","DOI":"10.3390\/onco5010002","author":"C Sousa","year":"2025","unstructured":"Sousa, C. & Videira, M. Dual approaches in oncology: The promise of siRNA and chemotherapy combinations in cancer therapies. Onco (Basel) https:\/\/doi.org\/10.3390\/onco5010002 (2025).","journal-title":"Onco (Basel)"},{"issue":"1","key":"1929_CR112","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s12088-024-01373-9","volume":"65","author":"K Umadevi","year":"2025","unstructured":"Umadevi, K., Sundeep, D., Vighnesh, A. R., Misra, A. & Krishna, A. G. Current trends and advances in nanoplatforms-based imaging for cancer diagnosis. Indian J Microbiol, 65(1), 137\u201376, https:\/\/doi.org\/10.1007\/s12088-024-01373-9 (2025).","journal-title":"Indian J Microbiol"},{"issue":"29","key":"1929_CR113","doi-asserted-by":"publisher","first-page":"e2502315","DOI":"10.1002\/smll.202502315","volume":"21","author":"N Desai","year":"2025","unstructured":"Desai, N., Rana, D., Patel, M., Bajwa, N., Prasad, R. & Vora, L. K. Nanoparticle therapeutics in clinical perspective: Classification, marketed products, and regulatory landscape. Small, 21(29), e2502315, https:\/\/doi.org\/10.1002\/smll.202502315 (2025).","journal-title":"Small"},{"issue":"2","key":"1929_CR114","doi-asserted-by":"publisher","first-page":"2200146","DOI":"10.1002\/ppsc.202200146","volume":"40","author":"S Pedroso-Santana","year":"2023","unstructured":"Pedroso-Santana, S. & Fleitas-Salazar, N. The use of capping agents in the stabilization and functionalization of metallic nanoparticles for biomedical applications. Part Part Syst Charact, 40(2), 2200146, https:\/\/doi.org\/10.1002\/ppsc.202200146 (2023).","journal-title":"Part Part Syst Charact"},{"key":"1929_CR115","doi-asserted-by":"publisher","unstructured":"Yang, J., Zeng, H., Luo, Y., Chen, Y., Wang, M., & Wu, C., et al. (2024). Recent applications of PLGA in drug delivery systems. Polymers, 16. https:\/\/doi.org\/10.3390\/polym16182606","DOI":"10.3390\/polym16182606"},{"issue":"19","key":"1929_CR116","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.3390\/polym16192755","volume":"16","author":"X Liang","year":"2024","unstructured":"Liang, X., Zhong, H. J., Ding, H., Yu, B., Ma, X. & Liu, X. et al. Polyvinyl alcohol (PVA)-based hydrogels: Recent progress in fabrication, properties, and multifunctional applications. Polymers (Basel), 16(19), 2755, https:\/\/doi.org\/10.3390\/polym16192755 (2024).","journal-title":"Polymers (Basel)"},{"issue":"18","key":"1929_CR117","doi-asserted-by":"publisher","first-page":"e38165","DOI":"10.1016\/j.heliyon.2024.e38165","volume":"10","author":"R Sun","year":"2024","unstructured":"Sun, R., Chen, Y., Pei, Y., Wang, W., Zhu, Z. & Zheng, Z. et al. The drug release of PLGA-based nanoparticles and their application in treatment of gastrointestinal cancers. Heliyon, 10(18), e38165, https:\/\/doi.org\/10.1016\/j.heliyon.2024.e38165 (2024).","journal-title":"Heliyon"},{"key":"1929_CR118","doi-asserted-by":"publisher","unstructured":"Alshammari, F., Alshammari, B., Alshamari, A., Sarkar, K., & Thakur, R. (2025). Dual-phase ocular insert with bromfenac-loaded PLGA MPs in a PVA matrix for sustained postoperative anti-inflammatory delivery. Pharmaceutics, 17. https:\/\/doi.org\/10.3390\/pharmaceutics17081066","DOI":"10.3390\/pharmaceutics17081066"},{"issue":"2","key":"1929_CR119","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3390\/pharmaceutics16020273","volume":"16","author":"M Hassan","year":"2024","unstructured":"Hassan, M., Abdelnabi, H. A. & Mohsin, S. Harnessing the potential of PLGA nanoparticles for enhanced bone regeneration. Pharmaceutics, 16(2), 273, https:\/\/doi.org\/10.3390\/pharmaceutics16020273 (2024).","journal-title":"Pharmaceutics"},{"key":"1929_CR120","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-024-03280-y","author":"N Torabi Fard","year":"2024","unstructured":"Torabi Fard, N., Ahmad Panahi, H., Moniri, E., Reza Soltani, E. & Mahdavijalal, M. Stimuli-responsive dendrimers as nanoscale vectors in drug and gene delivery systems: A review study. J Polym Environ https:\/\/doi.org\/10.1007\/s10924-024-03280-y (2024).","journal-title":"J Polym Environ"},{"issue":"6","key":"1929_CR121","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1039\/d3cs00793f","volume":"53","author":"Y Hang","year":"2024","unstructured":"Hang, Y., Wang, A. & Wu, N. Plasmonic silver and gold nanoparticles: shape- and structure-modulated plasmonic functionality for point-of-caring sensing, bio-imaging and medical therapy. Chem Soc Rev., 53(6), 2932\u201371, https:\/\/doi.org\/10.1039\/d3cs00793f (2024).","journal-title":"Chem Soc Rev."},{"issue":"3","key":"1929_CR122","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.36922\/cp.2589","volume":"5","author":"SCB Gopinath","year":"2023","unstructured":"Gopinath, S. C. B. & Lakshmipriya, T. An update on Nanomaterial-based biosensing systems for discriminative diagnosis of breast cancer. Cancer Plus, 5(3), 2589, https:\/\/doi.org\/10.36922\/cp.2589 (2023).","journal-title":"Cancer Plus"},{"key":"1929_CR123","doi-asserted-by":"publisher","first-page":"1390099","DOI":"10.3389\/fpubh.2024.1390099","volume":"12","author":"F Wang","year":"2024","unstructured":"Wang, F., Zhou, L., Mu, D., Zhang, H., Zhang, G. & Huang, X. et al. Current research on ecotoxicity of metal-based nanoparticles: from exposure pathways, ecotoxicological effects to toxicity mechanisms. Front Public Health, 12, 1390099, https:\/\/doi.org\/10.3389\/fpubh.2024.1390099 (2024).","journal-title":"Front Public Health"},{"issue":"12","key":"1929_CR124","doi-asserted-by":"publisher","first-page":"9243","DOI":"10.1007\/s00210-024-03212-6","volume":"397","author":"B Mesut","year":"2024","unstructured":"Mesut, B., Al-Mohaya, M., Gholap, A. D., Ye\u015filkaya, E., Das, U. & Akhtar, M. S. et al. Demystifying the potential of lipid-based nanocarriers in targeting brain malignancies. Naunyn Schmiedebergs Arch Pharmacol, 397(12), 9243\u201379, https:\/\/doi.org\/10.1007\/s00210-024-03212-6 (2024).","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1929_CR125","doi-asserted-by":"publisher","unstructured":"Zheng, G., Zhang, B., Yu, H., Song, Z., Xu, X., & Zheng, Z., et al. (2025). Therapeutic applications and potential biological barriers of nano-delivery systems in common gastrointestinal disorders: a comprehensive review. Advanced Composites and Hybrid Materials, 8(2). https:\/\/doi.org\/10.1007\/s42114-025-01292-3","DOI":"10.1007\/s42114-025-01292-3"},{"key":"1929_CR126","doi-asserted-by":"publisher","unstructured":"Patel, P. R., & Haemmerich, D. (2024). Review on electrospray nanoparticles for drug delivery: Exploring applications. Polymers for Advanced Technologies, 35. https:\/\/doi.org\/10.1002\/pat.6507","DOI":"10.1002\/pat.6507"},{"issue":"1629803","key":"1929_CR127","doi-asserted-by":"publisher","first-page":"1629803","DOI":"10.3389\/fphar.2025.1629803","volume":"16","author":"X Yu","year":"2025","unstructured":"Yu, X., Lu, Y., Chen, J., Deng, Y. & Liu, H. Unlocking ginsenosides\u2019 therapeutic power with polymer-based delivery systems: current applications and future perspectives. Front Pharmacol, 16(1629803), 1629803, https:\/\/doi.org\/10.3389\/fphar.2025.1629803 (2025).","journal-title":"Front Pharmacol"},{"key":"1929_CR128","doi-asserted-by":"publisher","first-page":"22","DOI":"10.21037\/tbcr-23-32","volume":"4","author":"DR Radulski","year":"2023","unstructured":"Radulski, D. R., Stipp, M. C., Galindo, C. M. & Acco, A. Features and applications of Ehrlich tumor model in cancer studies: a literature review. Transl Breast Cancer Res, 4, 22, https:\/\/doi.org\/10.21037\/tbcr-23-32 (2023).","journal-title":"Transl Breast Cancer Res"},{"issue":"8","key":"1929_CR129","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-025-02865-4","volume":"42","author":"S Das","year":"2025","unstructured":"Das, S., Sahoo, S., Pattanaik, S., Prusty, R. K., Barik, B. & Satapathy, B. S. et al. Advancing breast cancer research: a comprehensive review of in vitro and in vivo experimental models. Med Oncol, 42(8), 316, https:\/\/doi.org\/10.1007\/s12032-025-02865-4 (2025).","journal-title":"Med Oncol"},{"issue":"10","key":"1929_CR130","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1002\/ijc.34849","volume":"154","author":"MP Sharma","year":"2024","unstructured":"Sharma, M. P., Shukla, S. & Misra, G. Recent advances in breast cancer cell line research. Int J Cancer, 154(10), 1683\u201393, https:\/\/doi.org\/10.1002\/ijc.34849 (2024).","journal-title":"Int J Cancer"},{"issue":"2","key":"1929_CR131","doi-asserted-by":"publisher","first-page":"e70059","DOI":"10.1002\/mco2.70059","volume":"6","author":"A Gu","year":"2025","unstructured":"Gu, A., Li, J., Li, M. Y. & Liu, Y. Patient-derived xenograft model in cancer: establishment and applications. MedComm, 6(2), e70059, https:\/\/doi.org\/10.1002\/mco2.70059 (2025).","journal-title":"MedComm"},{"issue":"7","key":"1929_CR132","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41388-023-02929-7","volume":"43","author":"MG Oser","year":"2024","unstructured":"Oser, M. G., MacPherson, D., Oliver, T. G., Sage, J. & Park, K. S. Genetically-engineered mouse models of small cell lung cancer: the next generation. Oncogene, 43(7), 457\u201369, https:\/\/doi.org\/10.1038\/s41388-023-02929-7 (2024).","journal-title":"Oncogene"},{"issue":"1","key":"1929_CR133","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58364-7","volume":"16","author":"TY Jeong","year":"2025","unstructured":"Jeong, T. Y., Yoon, D. E., Kim, S. P., Yang, J., Lim, S. Y. & Ok, S. et al. An innovative approach using CRISPR-ribonucleoprotein packaged in virus-like particles to generate genetically engineered mouse models. Nat Commun, 16(1), 3451, https:\/\/doi.org\/10.1038\/s41467-025-58364-7 (2025).","journal-title":"Nat Commun"},{"key":"1929_CR134","doi-asserted-by":"publisher","first-page":"1413858","DOI":"10.3389\/fimmu.2024.1413858","volume":"15","author":"S Huang","year":"2024","unstructured":"Huang, S., Mei, Z., Wan, A., Zhao, M. & Qi, X. Application and prospect of organoid technology in breast cancer. Front Immunol, 15, 1413858, https:\/\/doi.org\/10.3389\/fimmu.2024.1413858 (2024).","journal-title":"Front Immunol"},{"key":"1929_CR135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21873\/invivo.13800","volume":"39","author":"J Silva","year":"2024","unstructured":"Silva, J., Oliveira, P. A., Duarte, J. A. & Faustino-Rocha, A. Mammary cancer models: An overview from the past to the future. In Vivo, 39, 1\u201316, https:\/\/doi.org\/10.21873\/invivo.13800 (2024).","journal-title":"In Vivo"},{"issue":"2","key":"1929_CR136","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bpj.2020.06.007","volume":"119","author":"J Hou","year":"2020","unstructured":"Hou, J., Reid, N. E., Tromberg, B. J. & Potma, E. O. Kinetic analysis of lipid metabolism in breast cancer cells via nonlinear optical microscopy. Biophysical Journal, 119(2), 258\u201364, https:\/\/www.cell.com\/biophysj\/pdfExtended\/S0006-3495(20)30479-3 (2020).","journal-title":"Biophysical Journal"},{"key":"1929_CR137","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3389\/fonc.2019.00686","volume":"9","author":"DM Demas","year":"2019","unstructured":"Demas, D. M., Demo, S., Fallah, Y., Clarke, R., Nephew, K. P. & Althouse, S. et al. Glutamine metabolism drives growth in advanced hormone receptor positive breast cancer. Front Oncol, 9, 686, https:\/\/doi.org\/10.3389\/fonc.2019.00686 (2019).","journal-title":"Front Oncol"},{"issue":"4","key":"1929_CR138","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.neo.2021.02.003","volume":"23","author":"D Papadopoli","year":"2021","unstructured":"Papadopoli, D., Uchenunu, O., Palia, R., Chekkal, N., Hulea, L. & Topisirovic, I. et al. Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin. Neoplasia, 23(4), 391\u20139, https:\/\/doi.org\/10.1016\/j.neo.2021.02.003 (2021).","journal-title":"Neoplasia"},{"issue":"1\u20132","key":"1929_CR139","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s11010-018-3480-z","volume":"455","author":"W Zhuang","year":"2019","unstructured":"Zhuang, W., Lian, G., Huang, B., Du, A., Gong, J. & Xiao, G. et al. CPT1 regulates the proliferation of pulmonary artery smooth muscle cells through the AMPK-p53-p21 pathway in pulmonary arterial hypertension. Mol Cell Biochem, 455(1\u20132), 169\u201383, https:\/\/doi.org\/10.1007\/s11010-018-3480-z (2019).","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"1929_CR140","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1158\/1078-0432.CCR-19-2023","volume":"26","author":"M Quintela-Fandino","year":"2020","unstructured":"Quintela-Fandino, M., Morales, S., Cort\u00e9s-Salgado, A., Manso, L., Apala, J. V. & Mu\u00f1oz, M. et al. Randomized phase 0\/I trial of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early HER2-negative breast cancer. Clin Cancer Res, 26(1), 35\u201345, https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-2023 (2020).","journal-title":"Clin Cancer Res"},{"issue":"16","key":"1929_CR141","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1158\/1078-0432.CCR-17-3167","volume":"24","author":"S Thakur","year":"2018","unstructured":"Thakur, S., Daley, B., Gaskins, K., Vasko, V. V., Boufraqech, M. & Patel, D. et al. Metformin targets mitochondrial glycerophosphate dehydrogenase to control rate of oxidative phosphorylation and growth of thyroid cancer in vitro and in vivo. Clin Cancer Res, 24(16), 4030\u201343, https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-3167 (2018).","journal-title":"Clin Cancer Res"},{"issue":"3","key":"1929_CR142","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1158\/0008-5472.CAN-18-3985","volume":"80","author":"M Gale","year":"2020","unstructured":"Gale, M., Li, Y., Cao, J., Liu, Z. Z., Holmbeck, M. A. & Zhang, M. et al. Acquired resistance to HER2-targeted therapies creates vulnerability to ATP synthase inhibition. Cancer Res, 80(3), 524\u201335, https:\/\/doi.org\/10.1158\/0008-5472.CAN-18-3985 (2020).","journal-title":"Cancer Res"},{"key":"1929_CR143","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.freeradbiomed.2015.08.006","volume":"89","author":"KT Allen","year":"2015","unstructured":"Allen, K. T., Chin-Sinex, H., DeLuca, T., Pomerening, J. R., Sherer, J. & Watkins, J. B. 3rd et al. Dichloroacetate alters Warburg metabolism, inhibits cell growth, and increases the X-ray sensitivity of human A549 and H1299 NSC lung cancer cells. Free Radic Biol Med, 89, 263\u201373, https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.08.006 (2015).","journal-title":"Free Radic Biol Med"},{"key":"1929_CR144","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.2147\/cmar.s156530","volume":"10","author":"X Lu","year":"2018","unstructured":"Lu, X., Zhou, D., Hou, B., Liu, Q. X., Chen, Q. & Deng, X. F. et al. Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer. Cancer Manag Res, 10, 1231\u201341, https:\/\/doi.org\/10.2147\/cmar.s156530 (2018).","journal-title":"Cancer Manag Res"},{"issue":"2","key":"1929_CR145","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3892\/ijo.2010.851","volume":"38","author":"J Xie","year":"2011","unstructured":"Xie, J., Wang, B. S., Yu, D. H., Lu, Q., Ma, J. & Qi, H. et al. Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells. International Journal of Oncology, 38(2), 409\u201317, https:\/\/doi.org\/10.3892\/ijo.2010.851 (2011).","journal-title":"International Journal of Oncology"},{"key":"1929_CR146","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.ejphar.2016.08.004","volume":"789","author":"Z Yang","year":"2016","unstructured":"Yang, Z. & Tam, K. Y. Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines. European journal of pharmacology, 789, 458\u201367, https:\/\/www.dcaguide.org\/dca-information\/dca-papers-and-clinical-trials\/anti-cancer-synergy-of-dichloroacetate-and-egfr-tyrosine-kinase-inhibitors-in-nsclc-cell-lines\/ (2016).","journal-title":"European journal of pharmacology"},{"issue":"1","key":"1929_CR147","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08186-9","volume":"21","author":"J Parczyk","year":"2021","unstructured":"Parczyk, J., Ruhnau, J., Pelz, C., Schilling, M., Wu, H. & Piaskowski, N. N. et al. Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines. BMC Cancer, 21(1), 481, https:\/\/doi.org\/10.1186\/s12885-021-08186-9 (2021).","journal-title":"BMC Cancer"},{"issue":"2","key":"1929_CR148","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.bbrc.2017.05.097","volume":"489","author":"M Wang","year":"2017","unstructured":"Wang, M., Liao, C., Hu, Y., Pan, Q. & Jiang, J. Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy. Biochemical and biophysical research communications, 489(2), 103\u20138, https:\/\/www.dcaguide.org\/dca-information\/dca-papers-and-clinical-trials\/sensitization-of-breast-cancer-cells-to-paclitaxel-by-dichloroacetate-through-inhibiting-autophagy\/ (2017).","journal-title":"Biochemical and biophysical research communications"},{"issue":"5","key":"1929_CR149","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s00280-013-2281-z","volume":"72","author":"MF Zheng","year":"2013","unstructured":"Zheng, M. F., Shen, S. Y. & Huang, W. D. DCA increases the antitumor effects of capecitabine in a mouse B16 melanoma allograft and a human non-small cell lung cancer A549 xenograft. Cancer chemotherapy and pharmacology, 72(5), 1031\u201341, https:\/\/doi.org\/10.1007\/s00280-013-2281-z (2013).","journal-title":"Cancer chemotherapy and pharmacology"},{"key":"1929_CR150","doi-asserted-by":"publisher","unstructured":"Fraguas-S\u00e1nchez, A., Lozza I., & Torres-Su\u00e1rez, A. (2022). Actively targeted nanomedicines in breast cancer: From pre-clinal investigation to clinic. Cancers, 14. https:\/\/doi.org\/10.3390\/cancers14051198","DOI":"10.3390\/cancers14051198"},{"key":"1929_CR151","doi-asserted-by":"publisher","first-page":"1526718","DOI":"10.3389\/fonc.2025.1526718","volume":"15","author":"T You","year":"2025","unstructured":"You, T. & Zhang, S. Recent advances in PLGA polymer nanocarriers for ovarian cancer therapy. Front Oncol, 15, 1526718, https:\/\/doi.org\/10.3389\/fonc.2025.1526718 (2025).","journal-title":"Front Oncol"},{"issue":"5","key":"1929_CR152","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1208\/s12249-022-02214-y","volume":"23","author":"M Tang","year":"2022","unstructured":"Tang, M., Huang, Y., Liang, X., Tao, Y., He, N. & Li, Z. et al. Sorafenib-loaded PLGA-TPGS nanosystems enhance hepatocellular carcinoma therapy through reversing P-glycoprotein-mediated multidrug resistance. AAPS PharmSciTech, 23(5), 130, https:\/\/doi.org\/10.1208\/s12249-022-02214-y (2022).","journal-title":"AAPS PharmSciTech"},{"key":"1929_CR153","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.colsurfb.2019.03.011","volume":"178","author":"R Dom\u00ednguez-R\u00edos","year":"2019","unstructured":"Dom\u00ednguez-R\u00edos, R., S\u00e1nchez-Ram\u00edrez, D. R., Ruiz-Saray, K., Oceguera-Basurto, P. E., Almada, M. & Ju\u00e1rez, J. et al. Cisplatin-loaded PLGA nanoparticles for HER2 targeted ovarian cancer therapy. Colloids Surf B Biointerfaces., 178, 199\u2013207, https:\/\/doi.org\/10.1016\/j.colsurfb.2019.03.011 (2019).","journal-title":"Colloids Surf B Biointerfaces."},{"issue":"1","key":"1929_CR154","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3762\/bjnano.15.17","volume":"15","author":"PT Dang-Luong","year":"2024","unstructured":"Dang-Luong, P. T., Nguyen, H. P., Le-Tuan, L., Cao, X. T., Tran-Anh, V. & Quang, H. V. Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics. Beilstein Journal of Nanotechnology, 15(1), 180\u20139, https:\/\/www.beilstein-journals.org\/bjnano\/articles\/15\/17 (2024).","journal-title":"Beilstein Journal of Nanotechnology"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01929-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01929-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01929-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:47:58Z","timestamp":1772858878000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01929-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":154,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["1929"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01929-6","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"5 October 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments were conducted in accordance with the recommended national ethical guidelines for laboratory animal care and the Animal Ethical Committee of the Faculty of Science, Tanta University (protocol approval code Serial No. IACUC-SCI-TU-0210).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}