{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:09:33Z","timestamp":1772932173754,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"TUBAP","award":["2024\/51"],"award-info":[{"award-number":["2024\/51"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-025-01932-x","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T04:18:54Z","timestamp":1760674734000},"page":"1165-1175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Theranekron D6 Shows Selective Effects on HEL299, A549, and Hep3B cells, Indicating Potential in the Fight Against Cancer"],"prefix":"10.1007","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0693-3569","authenticated-orcid":false,"given":"Deniz","family":"\u015eUMNULU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"issue":"3","key":"1932_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., & Jemal, A. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Can J Clin, 71(3), 209\u2013249.","journal-title":"CA: A Can J Clin"},{"key":"1932_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/bs.ircmb.2020.01.003","volume":"352","author":"WD Fairlie","year":"2020","unstructured":"Fairlie, W. D., Tran, S., & Lee, E. F. (2020). Crosstalk between apoptosis and autophagy signaling pathways. Int Rev Cell Mol Biol, 352, 115\u2013158.","journal-title":"Int Rev Cell Mol Biol"},{"key":"1932_CR3","doi-asserted-by":"publisher","first-page":"603","DOI":"10.18632\/aging.100934","volume":"8","author":"G Pistritto","year":"2016","unstructured":"Pistritto, G., Trsiciuoglio, D., Ceci, C., Garufi, A., & D\u2019Orazi, G. (2016). Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies. Aging (Albany Ny), 8, 603\u2013619.","journal-title":"Aging (Albany Ny)"},{"key":"1932_CR4","doi-asserted-by":"publisher","first-page":"20855","DOI":"10.1074\/jbc.274.30.20855","volume":"274","author":"C Adrain","year":"1999","unstructured":"Adrain, C., Slee, E. A., Harte, M. T., & Martin, S. J. (1999). Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. Journal of Biological Chemistry, 274, 20855\u201320860.","journal-title":"Journal of Biological Chemistry"},{"key":"1932_CR5","doi-asserted-by":"publisher","first-page":"33489","DOI":"10.1074\/jbc.273.50.33489","volume":"273","author":"Y Hu","year":"1998","unstructured":"Hu, Y., Ding, L., Spencer, D. M., & Nunez, G. (1998). WD-40 repeat region regulates Apaf-1 selfassociation and procaspase-9 activation. Journal of Biological Chemistry, 273, 33489\u201333494.","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"1932_CR6","doi-asserted-by":"publisher","first-page":"9980","DOI":"10.1093\/emboj\/20.5.998","volume":"20","author":"SB Bratton","year":"2001","unstructured":"Bratton, S. B., Walker, G., Srinivasula, S. M., Sun, X. M., Butterworth, M., Alnemri, E. S., & Cohen, G. M. (2001). Recruitment, activation and retention of caspases-9 and \u2013\u20093 by Apaf-1 apoptosome and associated XIAP complexes. Embo Journal, 20(5), 9980\u20139989.","journal-title":"Embo Journal"},{"issue":"14","key":"1932_CR7","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.1074\/jbc.273.14.7787","volume":"273","author":"R Takahashi","year":"1998","unstructured":"Takahashi, R., Deveraux, Q., Tamm, I., Welsh, K., Assa-Munt, N., & Salvesen, G. S. (1998). A single BIR domain of XIAP sufficient for inhibiting caspases. Journal of Biological Chemistry, 273(14), 7787\u20137790.","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"1932_CR8","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S1097-2765(03)00054-6","volume":"11","author":"EN Shiozaki","year":"2003","unstructured":"Shiozaki, E. N., Chai, J., Rigotti, D. J., Riedl, S. J., Li, P., Srinivasula, S. M., Alnemri, E. S., Fairman, R., & Shi, Y. (2003). Mechanism of XIAP-mediated Inhibition of caspase-9. Molecular Cell, 11(2), 519\u2013527.","journal-title":"Molecular Cell"},{"issue":"5","key":"1932_CR9","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0092-8674(01)00274-4","volume":"104","author":"SJ Riedl","year":"2001","unstructured":"Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S. W., Liddington, R. C., & Salvesen, G. S. (2001). Structural basis for the Inhibition of caspase-3 by XIAP. Cell, 104(5), 791\u2013800.","journal-title":"Cell"},{"key":"1932_CR10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S0092-8674(01)00272-0","volume":"104","author":"J Chai","year":"2001","unstructured":"Chai, J., Shiozaki, E., Srinivasula, S. M., Wu, Q., Datta, P., Alnemri, E. S., & Shi, Y. (2001). Structural basis of caspase-7 Inhibition by XIAP. Cell, 104, 769\u2013780.","journal-title":"Cell"},{"key":"1932_CR11","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1074\/jbc.M109784200","volume":"277","author":"LM Martins","year":"2002","unstructured":"Martins, L. M., Iaccarino, I., Tenev, T., Gschmeissner, S., Totty, N. F., Lemoine, N. R., Savopoulos, J., Gray, C. W., Creasy, C. L., Dingwall, C., & Downward, J. (2002). The Serine protease Omi\/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. Journal of Biological Chemistry, 277, 439\u2013444.","journal-title":"Journal of Biological Chemistry"},{"key":"1932_CR12","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/35022514","volume":"406","author":"J Chai","year":"2000","unstructured":"Chai, J., Du, C., Wu, J. W., Kyin, S., Wang, X., & Shi, Y. (2000). Structural and biochemical basis of apoptotic activation by Smac\/DIABLO. Nature, 406, 855\u2013862.","journal-title":"Nature"},{"key":"1932_CR13","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/35065125","volume":"410","author":"SM Srinivasula","year":"2001","unstructured":"Srinivasula, S. M., Hegde, R., Saleh, A., Datta, P., Shiozaki, E., Chai, J., Lee, R. A., Robbins, P. D., Fernandes-Alnemri, T., Shi, Y., & Alnemri, E. S. (2001). A conserved XIAP-interaction motif in caspase-9 and Smac\/DIABLO regulates caspase activity and apoptosis. Nature, 410, 112\u2013116.","journal-title":"Nature"},{"issue":"7","key":"1932_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nrm3143","volume":"12","author":"D Vucic","year":"2011","unstructured":"Vucic, D., Dixit, V. M., & Wertz, I. E. (2011). Ubiquitylation in apoptosis: A post-translational modification at the edge of life and death. Nature Reviews Molecular Cell Biology, 12(7), 439\u2013452.","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"5689","key":"1932_CR15","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1126\/science.1098231","volume":"305","author":"L Li","year":"2004","unstructured":"Li, L., Thomas, R. M., Suzuki, H., De Brabander, J. K., Wang, X., & Harran, P. G. (2004). A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science, 305(5689), 1471\u20131474.","journal-title":"Science"},{"key":"1932_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroscience.2015.06.030","volume":"303","author":"XS Zhang","year":"2015","unstructured":"Zhang, X. S., Ha, S., Wang, X. L., Shi, Y. L., Duan, S. S., & Li, Z. A. (2015). Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153\/NF-E2-related factor 2\/antioxidant response element signaling pathway. Neuroscience, 303, 489\u2013502.","journal-title":"Neuroscience"},{"key":"1932_CR17","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1177\/0091270005282630","volume":"45","author":"L Zhou","year":"2005","unstructured":"Zhou, L., Zuo, Z., & Chow, M. S. (2005). Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. Journal of Clinical Pharmacology, 45, 1345\u20131359.","journal-title":"Journal of Clinical Pharmacology"},{"issue":"5","key":"1932_CR18","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1517\/13543784.2014.899350","volume":"23","author":"FE Lennon","year":"2014","unstructured":"Lennon, F. E., & Salgia, R. (2014). Mitochondrial dynamics: Biology and therapy in lung cancer. Exp Opin Inves Drugs, 23(5), 675\u2013692.","journal-title":"Exp Opin Inves Drugs"},{"issue":"9","key":"1932_CR19","doi-asserted-by":"publisher","first-page":"e1001399","DOI":"10.1371\/journal.pbio.1001399","volume":"10","author":"G Basanez","year":"2012","unstructured":"Basanez, G., Soane, L., & Hardwick, J. M. (2012). A new view of the lethal apoptotic pore. Plos Biology, 10(9), e1001399.","journal-title":"Plos Biology"},{"key":"1932_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12860-018-0174-z","volume":"19","author":"S Jieensinue","year":"2018","unstructured":"Jieensinue, S., Zhu, H., Li, G., Dong, K., Liang, M., & Li, Y. (2018). Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK-Mff signaling pathways. Bmc Cell Biology, 19, 21.","journal-title":"Bmc Cell Biology"},{"issue":"11","key":"1932_CR21","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1248\/bpb.33.1828","volume":"33","author":"SH Won","year":"2010","unstructured":"Won, S. H., Lee, H. J., Jeong, S. J., Lee, H. J., Lee, E. O., Jung, D. B., & Shin, J. M. (2010). Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an Inhibition of phosphoinositide 3-kinase\/AKT pathway. Biological &\/And Pharmaceutical Bulletin, 33(11), 1828\u20131834.","journal-title":"Biological &\/And Pharmaceutical Bulletin"},{"issue":"9","key":"1932_CR22","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1002\/ptr.6392","volume":"33","author":"XZ Liao","year":"2019","unstructured":"Liao, X. Z., Gao, Y., Huang, S., Chen, Z. Z., Sun, L. L., & Liu, J. H. (2019). Tanshinone IIA combined with cisplatin synergistically inhibits non-small-cell lung cancer in vitro and in vivo via down-regulating the phosphatidylinositol 3-kinase\/Akt signalling pathway. Phyt Res, 33(9), 2298\u20132309.","journal-title":"Phyt Res"},{"key":"1932_CR23","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/540516","author":"PY Tseng","year":"2014","unstructured":"Tseng, P. Y., Lu, W. C., Hsieh, M. J., Chien, S. Y., & Chen, M. K. (2014). Tanshinone IIA induces apoptosis in human oral cancer KB cells through a Mitochondria-Dependent pathway. BioMed Res Int. https:\/\/doi.org\/10.1155\/2014\/540516","journal-title":"BioMed Res Int"},{"issue":"1","key":"1932_CR24","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41420-023-01462-6","volume":"9","author":"J Schaf","year":"2023","unstructured":"Schaf, J., Shinhmar, S., Zeng, Q., Pardo, O. E., Beesley, P., & Syed, N. (2023). Enhanced sestrin expression through Tanshinone 2A treatment improves PI3Kdependent Inhibition of glioma growth. Cell Death Disc, 9(1), 172.","journal-title":"Cell Death Disc"},{"issue":"1","key":"1932_CR25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1186\/s12885-017-3329-y","volume":"17","author":"X Li","year":"2017","unstructured":"Li, X., Li, Z., Li, X., Liu, B., & Liu, Z. (2017). Mechanisms of Tanshinone II a inhibits malignant melanoma development through blocking autophagy signal transduction in A375 cell. Bmc Cancer, 17(1), 357.","journal-title":"Bmc Cancer"},{"issue":"5","key":"1932_CR26","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3892\/mmr.2021.12010","volume":"23","author":"Y Wang","year":"2021","unstructured":"Wang, Y., Jin, W., & Wang, J. (2021). Tanshinone IIA regulates microRNA-125b\/foxp3\/caspase-1 signaling and inhibits cell viability of nasopharyngeal carcinoma. Molecular Medicine Reports, 23(5), 371.","journal-title":"Molecular Medicine Reports"},{"issue":"2","key":"1932_CR27","first-page":"93","volume":"48","author":"A Gomes","year":"2010","unstructured":"Gomes, A., Bhattacharjee, P., Mishra, R., Biswas, A. K., Dasgupta, S. C., & Giri, B. (2010). Anticancer potential of animal venoms and toxins. Ind J Exp Biol, 48(2), 93\u2013103.","journal-title":"Ind J Exp Biol"},{"issue":"5","key":"1932_CR28","first-page":"704","volume":"49","author":"Z Paksoy","year":"2015","unstructured":"Paksoy, Z., G\u00fclesci, N., Kandemir, F. M., & Din\u00e7el, G. \u00c7. (2015). Effectiveness of levamisole and tarantula Cubensis extract in the treatment of teat papillomatosis of cows. Ind J Anim Res, 49(5), 704\u2013708.","journal-title":"Ind J Anim Res"},{"issue":"3","key":"1932_CR29","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00580-006-0657-8","volume":"16","author":"K Sardari","year":"2007","unstructured":"Sardari, K., Kakhki, E. G., & Mohri, M. (2007). Evaluation of wound contraction and epithelialization after subcutaneous administration of TheranekronR in cows. Comparative Clinical Pathology, 16(3), 197\u2013200.","journal-title":"Comparative Clinical Pathology"},{"key":"1932_CR30","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s43450-021-00221-x","volume":"31","author":"NG Tosun","year":"2021","unstructured":"Tosun, N. G., Kaplan, \u00d6., & \u00d6zg\u00fcr, A. (2021). Apoptosis induced by tarantula Cubensis crude venom (Theranekron\u00ae D6) in cancer cells. Rev Bras Farmacogn, 31, 824\u2013831.","journal-title":"Rev Bras Farmacogn"},{"issue":"1","key":"1932_CR31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.17776\/csj.1363685","volume":"45","author":"D \u015eumnulu","year":"2024","unstructured":"\u015eumnulu, D. (2024). Cytotoxic effects of Theranekron D6 on HepG2 heaptocellular carcinoma cells. Cumhuriyet Sci J, 45(1), 8\u201314.","journal-title":"Cumhuriyet Sci J"},{"key":"1932_CR32","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.58.3.10","volume":"58","author":"T-C Chou","year":"2006","unstructured":"Chou, T-C. (2006). Theoretical Basis, expreimental Design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacological Reviews, 58, 621\u2013681.","journal-title":"Pharmacological Reviews"},{"key":"1932_CR33","first-page":"118688","volume":"1867","author":"L Bouchier-Hayes","year":"2020","unstructured":"Bouchier-Hayes, L., & Boicea, A. (2020). Targeting apoptotic caspases in cancer. Biochim Biophys Mol Cell Res, 1867, 118688.","journal-title":"Biochim Biophys Mol Cell Res"},{"issue":"26","key":"1932_CR34","doi-asserted-by":"publisher","first-page":"19997","DOI":"10.1074\/jbc.M110.122127","volume":"285","author":"S Krautwald","year":"2010","unstructured":"Krautwald, S., Ziegler, E., Ro\u00a8lver, L., Linkermann, A., Keyser, K. A., Steen, P., Wollert, K. C., Korf-Klingebiel, M., & Kunzendorf, U. (2010). Effective blockage of both the extrinsic and intrinsic PathwaysofApoptosisinMicebyTAT-crmA. Journal of Biological Chemistry, 285(26), 19997\u201320005.","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"1932_CR35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-cancerbio-041916-065808","volume":"1","author":"CR Reczek","year":"2017","unstructured":"Reczek, C. R., & Chandel, N. S. (2017). The two faces of reactive oxygen species in cancer. Annu Rev Cancer Biol, 1(1), 79\u201398.","journal-title":"Annu Rev Cancer Biol"},{"issue":"2","key":"1932_CR36","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ccell.2019.12.012","volume":"37","author":"EC Cheung","year":"2020","unstructured":"Cheung, E. C., DeNicola, G. M., Nixon, C., Blyth, K., Labuschagne, C. F., & Tuveson, D. A. (2020). Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer. Cancer Cell, 37(2), 168\u2013182.","journal-title":"Cancer Cell"},{"key":"1932_CR37","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.freeradbiomed.2021.06.009","volume":"172","author":"A Cruz-Gregorio","year":"2021","unstructured":"Cruz-Gregorio, A., Aranda-Rivera, A. K., Ortega-Lozano, A. J., Pedraza-Chaverri, J., & Mendoza-Hoffmann, F. (2021). Lipid metabolism and oxidative stress in HPVrelated cancers. Free Radical Biology and Medicine, 172, 226\u2013236.","journal-title":"Free Radical Biology and Medicine"},{"issue":"1","key":"1932_CR38","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12929-022-00859-2","volume":"29","author":"CL Kuo","year":"2022","unstructured":"Kuo, C. L., Ponneri Babuharisankar, A., Lin, Y. C., Lien, H. W., Lo, Y. K., & Chou, H. Y. (2022). Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: Foe or friend? Journal of Biomedical Science, 29(1), 74.","journal-title":"Journal of Biomedical Science"},{"issue":"12","key":"1932_CR39","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","volume":"1863","author":"M Redza-Dutordoir","year":"2016","unstructured":"Redza-Dutordoir, M., & Averill-Bates, D. A. (2016). Activation of apoptosis signalling pathways by reactive oxygen species. Biochimica Et Biophysica Acta, 1863(12), 2977\u20132992.","journal-title":"Biochimica Et Biophysica Acta"},{"issue":"7","key":"1932_CR40","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrd2803","volume":"8","author":"D Trachootham","year":"2009","unstructured":"Trachootham, D., Alexandre, J., & Huang, P. (2009). Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat Rev Drug Dis, 8(7), 579\u2013591.","journal-title":"Nat Rev Drug Dis"},{"issue":"5\u20136","key":"1932_CR41","doi-asserted-by":"publisher","first-page":"152","DOI":"10.18632\/oncoscience.431","volume":"5","author":"S Navaneetha Krishnan","year":"2018","unstructured":"Navaneetha Krishnan, S., Rosales, J. L., & Lee, K. Y. (2018). Targeting Cdk5 for killing of breast cancer cells via perturbation of redox homeostasis. Oncoscience, 5(5\u20136), 152\u2013154.","journal-title":"Oncoscience"},{"key":"1932_CR42","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jss.2006.12.551","volume":"142","author":"S Huerta","year":"2007","unstructured":"Huerta, S., Heinzerling, J. H., Anguiano-Hernandez, Y. M., Huerta-Yepez, S., Lin, J., Chen, D., Bonavida, B., & Livingston, E. H. (2007). Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: Roles of Fas, Apaf-1, NFB, IAPs, Smac\/DIABLO, and AIF. Journal of Surgical Research, 142, 184\u2013194.","journal-title":"Journal of Surgical Research"},{"issue":"27","key":"1932_CR43","doi-asserted-by":"publisher","first-page":"24453","DOI":"10.1074\/jbc.C100074200","volume":"276","author":"D Chauhan","year":"2001","unstructured":"Chauhan, D., Hideshima, T., Rosen, S., Reed, J. C., Kharbanda, S., & Anderson, K. C. (2001). Apaf-1\/Cytochrome c-independent and smacdependent induction of apoptosis in multiple myeloma (MM) cells. Journal of Biological Chemistry, 276(27), 24453\u201324456.","journal-title":"Journal of Biological Chemistry"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01932-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-025-01932-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-025-01932-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T06:02:35Z","timestamp":1772863355000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-025-01932-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["1932"],"URL":"https:\/\/doi.org\/10.1007\/s12013-025-01932-x","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"7 October 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not involve human participants; therefore, informed consent is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The author declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}