{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:04:15Z","timestamp":1780488255211,"version":"3.54.1"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-01997-2","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T03:41:42Z","timestamp":1768362102000},"page":"2347-2368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardio Protective Role of Graphene-based Fe2O3 Nanozymes against isoproterenol-induced Myocardial Infarction by Moderating Oxidative Stress and Inflammation"],"prefix":"10.1007","volume":"84","author":[{"given":"Kousar","family":"Rasheed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazish","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"issue":"10","key":"1997_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S1473-3099(09)70233-6","volume":"9","author":"C Warren-Gash","year":"2009","unstructured":"Warren-Gash, C., Smeeth, L., & Hayward, A. C. (2009). Influenza as A trigger for acute myocardial infarction or death from cardiovascular disease: A systematic review. The Lancet Infectious Diseases, 9(10), 601\u2013610.","journal-title":"The Lancet Infectious Diseases"},{"issue":"36","key":"1997_CR2","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1093\/eurheartj\/ehaf367","volume":"46","author":"I. R. van Kelters","year":"2025","unstructured":"Kelters, I. R., Koop, Y., Young, M. E., Daiber, A., & van Laake, L. W. (2025). Circadian rhythms in cardiovascular disease. European Heart Journal, 46(36), 3532\u20133545.","journal-title":"European Heart Journal"},{"issue":"22","key":"1997_CR3","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/j.jacc.2007.09.011","volume":"50","author":"K Thygesen","year":"2007","unstructured":"Thygesen, K., Alpert, J. S., White, H. D., & Infarction, J. E. A. A. W. T. F. R. M. (2007). Universal definition of myocardial infarction. Journal of the American College of Cardiology, 50(22), 2173\u20132195.","journal-title":"Journal of the American College of Cardiology"},{"issue":"13","key":"1997_CR4","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1056\/NEJM200009283431303","volume":"343","author":"JA Goldstein","year":"2000","unstructured":"Goldstein, J. A., Demetriou, D., Grines, C. L., Pica, M., Shoukfeh, M., & O\u2019Neill, W. W. (2000). Multiple complex coronary plaques in patients with acute myocardial infarction. New England Journal of Medicine, 343(13), 915\u2013922.","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"1997_CR5","doi-asserted-by":"publisher","first-page":"101754","DOI":"10.1016\/j.dhjo.2024.101754","volume":"18","author":"IY Cho","year":"2025","unstructured":"Cho, I. Y., Koo, H. Y., Um, Y. J., Park, Y-M-M., Kim, K. M., Lee, C. E., et al. (2025). Intellectual disabilities and risk of cardiovascular diseases: A population-based cohort study. Disability and Health Journal, 18(2), 101754.","journal-title":"Disability and Health Journal"},{"key":"1997_CR6","doi-asserted-by":"publisher","first-page":"101269","DOI":"10.1016\/j.nantod.2021.101269","volume":"40","author":"H. Wei","year":"2021","unstructured":"Wei, H., Gao, L., Fan, K., Liu, J., He, J., & Qu, X. (2021). Nanozymes: A clear definition with fuzzy edges. Nano Today, 40, 101269.","journal-title":"Nano Today"},{"issue":"13","key":"1997_CR7","doi-asserted-by":"publisher","first-page":"2204809","DOI":"10.1002\/smll.202204809","volume":"19","author":"Y. Zhang","year":"2023","unstructured":"Zhang, Y., Liu, W., Wang, X., Liu, Y., & Wei, H. J. S. (2023). Nanozyme-enabled treatment of cardio\u2010and cerebrovascular diseases. Small (Weinheim An Der Bergstrasse, Germany), 19(13), 2204809.","journal-title":"Small (Weinheim An Der Bergstrasse, Germany)"},{"issue":"1","key":"1997_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.15212\/AMM-2024-0046","volume":"4","author":"L Liu","year":"2025","unstructured":"Liu, L., Lv, J., Wang, X., Huang, X. T., Zhang, C., Pan, Q., et al. (2025). Targeted nanozyme-enabled treatment of cardiovascular diseases. Acta Materia Medica, 4(1), 70\u201381.","journal-title":"Acta Materia Medica"},{"issue":"2","key":"1997_CR9","first-page":"1473","volume":"8","author":"SFC Araujo","year":"2025","unstructured":"Araujo, S. F. C., da Silva Fonseca, R. A., & Araujo, A. S. (2025). Catalytic nanomedicine: Antioxidant action and clinical benefits using cerium oxide nanoparticles. Precision Nanomedicine, 8(2), 1473\u20131481.","journal-title":"Precision Nanomedicine"},{"key":"1997_CR10","doi-asserted-by":"crossref","unstructured":"Malik, K., Kazmi, A., Sultana, T., Raja, N. I., Bibi, Y., Abbas, M. (2025). A mechanistic overview on green assisted formulation of nanocomposites and their multifunctional role in biomedical applications. Heliyon,11(3).","DOI":"10.1016\/j.heliyon.2025.e41654"},{"issue":"6","key":"1997_CR11","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1007\/s11696-022-02130-2","volume":"76","author":"D. Mundekkad","year":"2022","unstructured":"Mundekkad, D., & Alex, A. V. J. C. P. (2022). Analysis of structural and biomimetic characteristics of the green-synthesized Fe3O4 nanozyme from the fruit Peel extract of Punica granatum. Chemical Papers, 76(6), 3863\u20133878.","journal-title":"Chemical Papers"},{"issue":"11","key":"1997_CR12","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.2174\/1389200218666171016100507","volume":"18","author":"A. A. P. Khan","year":"2017","unstructured":"Khan, A. A. P., Khan, A., Asiri, A. M., Ashraf, G. M., & Alhogbia, B. G. J. C. D. M. (2017). Graphene oxide based metallic nanoparticles and their some biological and environmental application. Current Drug Metabolism, 18(11), 1020\u20131029.","journal-title":"Current Drug Metabolism"},{"issue":"4","key":"1997_CR13","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1007\/s00210-024-03495-9","volume":"398","author":"D. Abdelmoneim","year":"2025","unstructured":"Abdelmoneim, D., Eldomany, E. B., El-Adl, M., Farghali, A., El-Sayed, G., & El-Sherbini, E. S. J. N. S. A. P. (2025). Possible protective effect of natural Flavanone naringenin-reduced graphene oxide nanosheets on nonalcoholic fatty liver disease. Naunyn-Schmiedeberg's Archives of Pharmacology, 398(4):4071\u20134086.","journal-title":"Naunyn-Schmiedeberg's Archives of Pharmacology"},{"key":"1997_CR14","doi-asserted-by":"crossref","unstructured":"Sun, G., Wang, W., Zou, R., He, T., Wang, X., Cui, H. (2025). Efficient solid acid-catalyzed Preparation of 25-OH-ginsenoside Rf and its enhanced cardioprotective effects against Doxorubicin-induced cardiotoxicity. New Journal of Chemistry.","DOI":"10.1039\/D5NJ00980D"},{"issue":"3","key":"1997_CR15","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3390\/ijms26030915","volume":"26","author":"S Stankovic","year":"2025","unstructured":"Stankovic, S., Mutavdzin Krneta, S., Djuric, D., Milosevic, V., & Milenkovic, D. (2025). Plant polyphenols as heart\u2019s best friends: From health Properties, to cellular Effects, to molecular mechanisms of action. International Journal of Molecular Sciences, 26(3), 915.","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"1997_CR16","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s12265-025-10660-9","volume":"18","author":"Y. Mao","year":"2025","unstructured":"Mao, Y., Wang, R., Shi, X., Jin, Y., Pan, Z., & Chatterjee, E. (2025). Nanoparticles for rescue: Innovative therapeutic strategy for cardiac repair after myocardial infarction. Journal of Cardiovascular Translational Research, 18(5), 1113\u20131131.","journal-title":"Journal of Cardiovascular Translational Research"},{"key":"1997_CR17","doi-asserted-by":"publisher","first-page":"129328","DOI":"10.1016\/j.chemosphere.2020.129328","volume":"268","author":"P. K. Boruah","year":"2021","unstructured":"Boruah, P. K., Darabdhara, G., & Das, M. R. J. C. (2021). Polydopamine functionalized graphene sheets decorated with magnetic metal oxide nanoparticles as efficient nanozyme for the detection and degradation of harmful triazine pesticides. Chemosphere, 268, 129328.","journal-title":"Chemosphere"},{"issue":"5","key":"1997_CR18","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s12265-025-10660-9","volume":"18","author":"Y. Mao","year":"2025","unstructured":"Mao, Y., Wang, R., Shi, X., Jin, Y., Pan, Z., & Chatterjee, E. (2025). Nanoparticles for rescue: Innovative therapeutic strategy for cardiac repair after myocardial infarction. Journal of Cardiovascular Translational Research, 18(5), 1113\u20131131.","journal-title":"Journal of Cardiovascular Translational Research"},{"issue":"10","key":"1997_CR19","doi-asserted-by":"publisher","first-page":"6722","DOI":"10.1021\/acsabm.0c00632","volume":"3","author":"N Yadav","year":"2020","unstructured":"Yadav, N., Kannan, D., Patil, S., Singh, S., & Lochab, B. (2020). Amplified activity of Artesunate mediated by iron oxide nanoparticles loaded on a graphene oxide carrier for cancer therapeutics. ACS Applied Bio Materials, 3(10), 6722\u20136736.","journal-title":"ACS Applied Bio Materials"},{"issue":"4","key":"1997_CR20","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3390\/bios12040244","volume":"12","author":"I Badillo-Ram\u00edrez","year":"2022","unstructured":"Badillo-Ram\u00edrez, I., Carre\u00f3n, Y. J., Rodr\u00edguez-Almaz\u00e1n, C., Medina-Dur\u00e1n, C. M., Islas, S. R., & Saniger, J. M. (2022). Graphene-based biosensors for molecular chronic inflammatory disease biomarker detection. Biosensors, 12(4), 244.","journal-title":"Biosensors"},{"key":"1997_CR21","doi-asserted-by":"publisher","first-page":"1125571","DOI":"10.3389\/fcvm.2024.1125571","volume":"11","author":"GC Pereira","year":"2024","unstructured":"Pereira, G. C. (2024). A novel degradable PEG superparamagnetic iron oxide capsule coupled with a polyphenolic nano-enzymatic conjugate (PSPM-NE), to treat ROS-driven cardiovascular-diseases, tested in atherosclerosis as a model disease, and hypothesizing autoimmunity as an atheroma\u2019s trigger. Frontiers in Cardiovascular Medicine, 11, 1125571.","journal-title":"Frontiers in Cardiovascular Medicine"},{"key":"1997_CR22","doi-asserted-by":"publisher","first-page":"113490","DOI":"10.1016\/j.inoche.2024.113490","volume":"170","author":"HS Jabbar","year":"2024","unstructured":"Jabbar, H. S., Smail, H. A., Saeed, I. Q., Ibrahim, W. M., & Muhammad, H. Y. (2024). Pomegranate Peel extract for green synthesis of magnetite (Fe3O4) nanozymes as a colorimetric probe for determination of diclofenac. Inorganic Chemistry Communications, 170, 113490.","journal-title":"Inorganic Chemistry Communications"},{"issue":"1","key":"1997_CR23","doi-asserted-by":"publisher","first-page":"2405597","DOI":"10.1002\/advs.202405597","volume":"12","author":"J Xing","year":"2025","unstructured":"Xing, J., Ma, X., Yu, Y., Xiao, Y., Chen, L., Yuan, W., et al. (2025). A cardiac-Targeting and anchoring bimetallic cluster nanozyme alleviates Chemotherapy\u2010Induced cardiac ferroptosis and PANoptosis. Advanced Science, 12(1), 2405597.","journal-title":"Advanced Science"},{"issue":"20","key":"1997_CR24","doi-asserted-by":"publisher","first-page":"7228","DOI":"10.3390\/ma15207228","volume":"15","author":"N. M\u00e9ndez-Lozano","year":"2022","unstructured":"M\u00e9ndez-Lozano, N., P\u00e9rez-Reynoso, F., & Gonz\u00e1lez-Guti\u00e9rrez, C. J. M. (2022). Eco-friendly approach for graphene oxide synthesis by modified hummers method. Materials, 15(20), 7228.","journal-title":"Materials"},{"issue":"1","key":"1997_CR25","first-page":"20","volume":"26","author":"S Tripathi","year":"2025","unstructured":"Tripathi, S., Gangwar, N., Gangwar, C., & Shukla, R. J. S. (2025). Imaging. Enhanced humidity sensing using graphene oxide and reduced graphene oxide synthesized via modified. Hummers\u2019 Method, 26(1), 20.","journal-title":"Hummers\u2019 Method"},{"key":"1997_CR26","doi-asserted-by":"crossref","unstructured":"Hu, J., Ren, Q., Fan, D., Wu, W., Zhang, X., Wang, D., et al. (2025). Two-Dimensional nanozyme based on iron Metal\u2013Organic Gel\/Carboxylated graphene oxide for electrochemical and colorimetric Dual-Mode detection of hydrogen peroxide. ACS Applied Nano Materials.","DOI":"10.1021\/acsanm.4c06510"},{"issue":"1","key":"1997_CR27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11220-025-00547-z","volume":"26","author":"S Tripathi","year":"2025","unstructured":"Tripathi, S., Gangwar, N., Gangwar, C., & Shukla, R. (2025). Enhanced humidity sensing using graphene oxide and reduced graphene oxide synthesized via modified hummers\u2019 method. Sensing and Imaging, 26(1), 20.","journal-title":"Sensing and Imaging"},{"issue":"8","key":"1997_CR28","doi-asserted-by":"publisher","first-page":"e202401479","DOI":"10.1002\/asia.202401479","volume":"20","author":"K Bharti","year":"2025","unstructured":"Bharti, K., Dalal, S., Tyagi, A., & Sadhu, K. (2025). Dual activities of Flower-Like Gold\u2010Iron oxide nanozyme for Peroxidase\u2010Mimicking and glucose detection. Chemistry\u2013An Asian Journal, 20(8), e202401479.","journal-title":"Chemistry\u2013An Asian Journal"},{"key":"1997_CR29","doi-asserted-by":"crossref","unstructured":"Suhag, S., Yadav, P., Sachdeva, V., Lohan, K., Luhach, V., & Hooda, V. (2025). Enhancing cellulase performance through nanomaterials and mofs: Innovations and applications. Preparative Biochemistry & Biotechnology. 1\u201322.","DOI":"10.1080\/10826068.2025.2494105"},{"issue":"7","key":"1997_CR30","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s00604-025-07276-w","volume":"192","author":"AA Ashour","year":"2025","unstructured":"Ashour, A. A., Tayeb, F. J., Felemban, M. F., & Shafie, A. (2025). Nanomaterial-based biosensors for cancer diagnosis: Trends and innovations (2022\u20132025). Microchimica Acta, 192(7), 404.","journal-title":"Microchimica Acta"},{"key":"1997_CR31","doi-asserted-by":"publisher","first-page":"110635","DOI":"10.1016\/j.colsurfb.2019.110635","volume":"185","author":"W Bei","year":"2020","unstructured":"Bei, W., Jing, L., & Chen, N. (2020). Cardio protective role of Wogonin loaded nanoparticle against isoproterenol induced myocardial infarction by moderating oxidative stress and inflammation. Colloids and Surfaces B: Biointerfaces, 185, 110635.","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"key":"1997_CR32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.lfs.2019.04.056","volume":"227","author":"A Ardjmand","year":"2019","unstructured":"Ardjmand, A., Shahaboddin, M. E., Mazoochi, T., & Ghavipanjeh, G. (2019). Ameliorative effects of cerebrolysin against isoproterenol-induced myocardial injury in male rats. Life Sciences, 227, 187\u2013192.","journal-title":"Life Sciences"},{"issue":"4","key":"1997_CR33","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/ddr.21517","volume":"80","author":"C Zhu","year":"2019","unstructured":"Zhu, C., Li, W., Wang, X., Xue, J., Zhao, L., Song, Y., et al. (2019). Phloroglucinol averts isoprenaline hydrochloride induced myocardial infarction in rats. Drug Development Research, 80(4), 453\u2013460.","journal-title":"Drug Development Research"},{"key":"1997_CR34","unstructured":"Boulaares, I., Derouiche, S., Chetehouna, S., & Niemann, J. (2025). Green synthesis of manganese oxide nanoparticles using Basil extract for biocompatibility and therapeutic targeting of Metribuzin poisoned heart and lung tissues in Wistar rats. Archives of Razi Institute."},{"issue":"3","key":"1997_CR35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.etp.2010.07.009","volume":"64","author":"M. N. Shahzad","year":"2012","unstructured":"Shahzad, M. N., Javed, M. T., Shabir, S., Irfan, M., Hussain, R. J. E., & Pathology, T. (2012). Effects of feeding Urea and copper sulphate in different combinations on live body weight, carcass weight, percent weight to body weight of different organs and histopathological tissue changes in broilers. Experimental and Toxicologic Pathology, 64(3), 141\u2013147.","journal-title":"Experimental and Toxicologic Pathology"},{"key":"1997_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2014.10.002","volume":"79","author":"C Zeng","year":"2015","unstructured":"Zeng, C., Zhong, P., Zhao, Y., Kanchana, K., Zhang, Y., Khan, Z. A., et al. (2015). Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-\u03baB both in vitro and in vivo. Journal of Molecular and Cellular Cardiology, 79, 1\u201312.","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"2","key":"1997_CR37","doi-asserted-by":"publisher","first-page":"7","DOI":"10.33640\/2405-609X.3404","volume":"11","author":"HQ Al-assdy","year":"2025","unstructured":"Al-assdy, H. Q., Al-Tamimi, W. H., & Almansoory, A. F. (2025). Treatment wastewater of oil refinery by Fe2O3 NPs produce by the novel Alishewanella Jeotgali strain HAQ8. Karbala International Journal of Modern Science, 11(2), 7.","journal-title":"Karbala International Journal of Modern Science"},{"issue":"4","key":"1997_CR38","doi-asserted-by":"publisher","first-page":"4071","DOI":"10.1007\/s00210-024-03495-9","volume":"398","author":"D Abdelmoneim","year":"2025","unstructured":"Abdelmoneim, D., Eldomany, E. B., El-Adl, M., Farghali, A., El-Sayed, G., & El-Sherbini, E. S. (2025). Possible protective effect of natural Flavanone naringenin-reduced graphene oxide nanosheets on nonalcoholic fatty liver disease. Naunyn-Schmiedeberg\u2019s Archives of Pharmacology, 398(4), 4071\u20134086.","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"key":"1997_CR39","doi-asserted-by":"crossref","unstructured":"Nu\u00f1ez, J. M., LimaJr, E., Lohr JHn, V\u00e1squez Mansilla, M., Zysler, R. D., Tolley, A., et al. (2025). Phase stability and structural evolution of Core\/Shell iron oxide nanoparticles due to oxidative diffusion: Implications for spintronic applications. ACS Applied Nano Materials.","DOI":"10.1021\/acsanm.5c01929"},{"key":"1997_CR40","doi-asserted-by":"crossref","unstructured":"Abdullah, W., Razak, N. N. A. N. A., Dheyab, M. A., Salem, F., Aziz, A. A., Alanezi, S. T. (2025). Melanin-Driven green synthesis and surface modification of metal and metal\u2010Oxide nanoparticles for biomedical applications. Advanced Functional Materials. :2503017.","DOI":"10.1002\/adfm.202503017"},{"key":"1997_CR41","unstructured":"Bhat, F. A., Najmi, A. K., Aqil, M., Haque, S. E., Akhtar, M., & Kamthan, M. Development and Evaluation of a Dapagliflozin-Loaded Bilosomal Nanocarrier for Enhanced Cardioprotection in Isoproterenol-Induced Heart Failure in Rats. Available at SSRN 5292626."},{"issue":"1","key":"1997_CR42","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12896-024-00912-y","volume":"24","author":"R Li","year":"2024","unstructured":"Li, R., Xu, A., Chen, Y., Li, Y., Fu, R., Jiang, W., et al. (2024). Fabrication of apigenin and adenosine-loaded nanoparticles against doxorubicin-induced myocardial infarction by reducing inflammation and oxidative stress. BMC Biotechnology, 24(1), 87.","journal-title":"BMC Biotechnology"},{"key":"1997_CR43","doi-asserted-by":"publisher","first-page":"124047","DOI":"10.1016\/j.ijpharm.2024.124047","volume":"655","author":"J Jing","year":"2024","unstructured":"Jing, J., Fang, S., Li, Y., Liu, W., Wang, C., Lan, Y., et al. (2024). An enhanced cardio-protective effect of nanoparticles loaded with active components from polygonum orientale L. against isoproterenol-induced myocardial ischemia in rats. International Journal of Pharmaceutics, 655, 124047.","journal-title":"International Journal of Pharmaceutics"},{"key":"1997_CR44","unstructured":"Hasanzadeh-Moghadam, M., Khadem-Ansari, M. H., Farjah, G. H., & Rasmi, Y. (Eds.). (2018). Hepatoprotective effects of betaine on liver damages followed by myocardial infarction. Veterinary Research Forum."},{"key":"1997_CR45","doi-asserted-by":"publisher","first-page":"1551141","DOI":"10.3389\/fphar.2025.1551141","volume":"16","author":"L Wang","year":"2025","unstructured":"Wang, L., Lin, F., Miao, R., Zhao, T., Liu, Y., Yang, L., et al. (2025). Cardiac protection of Wogonin in mice with pulmonary fibrosis by regulating Sirt1\/\u03b3-H2AX pathway. Frontiers in Pharmacology, 16, 1551141.","journal-title":"Frontiers in Pharmacology"},{"key":"1997_CR46","doi-asserted-by":"crossref","unstructured":"Kamal, N. H., Heikal, L. A., & Abdallah, O. Y. (2025). The future of cardiac repair: A review on cell-free nanotherapies for regenerative myocardial infarction. Drug Delivery and Translational Research. :1\u201319.","DOI":"10.1007\/s13346-024-01763-y"},{"key":"1997_CR47","doi-asserted-by":"publisher","first-page":"215937","DOI":"10.1016\/j.ccr.2024.215937","volume":"517","author":"S Shahraki","year":"2024","unstructured":"Shahraki, S., Vaziri, E., Saboury, A. A., & Fan, K. (2024). Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications. Coordination Chemistry Reviews, 517, 215937.","journal-title":"Coordination Chemistry Reviews"},{"issue":"1","key":"1997_CR48","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/clinchem\/hvaa281","volume":"67","author":"I. A. Katrukha","year":"2021","unstructured":"Katrukha, I. A., & Katrukha, A. G. J. C. (2021). Myocardial injury and the release of troponins I and T in the blood of patients. Clinical chemistry, 67(1), 124\u2013130.","journal-title":"Clinical chemistry"},{"issue":"6673","key":"1997_CR49","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.adg8392","volume":"382","author":"L Xie","year":"2023","unstructured":"Xie, L., Yin, L., Yu, Y., Peng, G., Song, S., Ying, P., et al. (2023). Screening strategy for developing thermoelectric interface materials. Science, 382(6673), 921\u2013928.","journal-title":"Science"},{"issue":"4","key":"1997_CR50","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.jsps.2017.04.027","volume":"25","author":"W Gao","year":"2017","unstructured":"Gao, W., Wang, Y., Basavanagoud, B., & Jamil, M. K. (2017). Characteristics studies of molecular structures in drugs. Saudi Pharmaceutical Journal, 25(4), 580\u2013586.","journal-title":"Saudi Pharmaceutical Journal"},{"issue":"1","key":"1997_CR51","doi-asserted-by":"publisher","first-page":"7244677","DOI":"10.1155\/2021\/7244677","volume":"2021","author":"V Mihailovic","year":"2021","unstructured":"Mihailovic, V., Katanic Stankovic, J. S., Selakovic, D., & Rosic, G. (2021). An overview of the beneficial role of antioxidants in the treatment of Nanoparticle-Induced toxicities. Oxidative Medicine and Cellular Longevity, 2021(1), 7244677.","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"17","key":"1997_CR52","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1089\/ars.2014.6123","volume":"22","author":"MA Aon","year":"2015","unstructured":"Aon, M. A., Tocchetti, C. G., Bhatt, N., Paolocci, N., & Cortassa, S. (2015). Protective mechanisms of mitochondria and heart function in diabetes. Antioxidants & Redox Signaling, 22(17), 1563\u20131586.","journal-title":"Antioxidants & Redox Signaling"},{"issue":"1","key":"1997_CR53","first-page":"1","volume":"6","author":"C Wang","year":"2021","unstructured":"Wang, C., Wang, Z., Wang, G., Lau, J. Y. N., Zhang, K., & Li, W. (2021). COVID-19 in early 2021: Current status and looking forward. Signal Transduction and Targeted Therapy, 6(1), 1\u201314.","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"05","key":"1997_CR54","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","volume":"135","author":"C Xia","year":"2022","unstructured":"Xia, C., Dong, X., Li, H., Cao, M., Sun, D., He, S., et al. (2022). Cancer statistics in China and united States, 2022: profiles, trends, and determinants. Chinese Medical Journal, 135(05), 584\u2013590.","journal-title":"Chinese Medical Journal"},{"issue":"4","key":"1997_CR55","doi-asserted-by":"publisher","first-page":"042009","DOI":"10.1088\/2631-7990\/acf254","volume":"5","author":"S Sui","year":"2023","unstructured":"Sui, S., Guo, S., Ma, D., Guo, C., Wu, X., Zhang, Z., et al. (2023). Additive manufacturing of magnesium and its alloys: process-formability-microstructure-performance relationship and underlying mechanism. International Journal of Extreme Manufacturing, 5(4), 042009.","journal-title":"International Journal of Extreme Manufacturing"},{"key":"1997_CR56","doi-asserted-by":"crossref","unstructured":"Singh, A. K., Vishwakarma, S., Yadav, R., Patel, V. K., & Makam, P. (2025). Rosy. Graphitic carbon Nitride-Copper oxide nanocomposites with enhanced Peroxidase-Mimicking and electrocatalytic activity for vitamin B12 detection. ACS Applied Nano Materials.8(33), pp.16553-16567.","DOI":"10.1021\/acsanm.5c03201"},{"key":"1997_CR57","doi-asserted-by":"publisher","first-page":"100461","DOI":"10.1016\/j.prmcm.2024.100461","volume":"12","author":"P. Jurel","year":"2024","unstructured":"Jurel, P., Bahadur, S., & Bajpai, M. (2024). Emerging trends in Pharmacological and therapeutic potential of glycyrrhizic acids: Traditional and Nanotechnological approach. Pharmacological Research-Modern Chinese Medicine, 12, 100461.","journal-title":"Pharmacological Research-Modern Chinese Medicine"},{"key":"1997_CR58","doi-asserted-by":"publisher","first-page":"109816","DOI":"10.1016\/j.envres.2020.109816","volume":"188","author":"B Maher","year":"2020","unstructured":"Maher, B., Gonz\u00e1lez-Maciel, A., Reynoso-Robles, R., Torres-Jard\u00f3n, R., & Calder\u00f3n-Garcidue\u00f1as, L. (2020). Iron-rich air pollution nanoparticles: An unrecognised environmental risk factor for myocardial mitochondrial dysfunction and cardiac oxidative stress. Environmental Research, 188, 109816.","journal-title":"Environmental Research"},{"issue":"10","key":"1997_CR59","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3390\/antiox8100504","volume":"8","author":"P-M. Boarescu","year":"2019","unstructured":"Boarescu, P-M., Boarescu, I., Boc\u0219an, I. C., Gheban, D., Bulboac\u0103, A. E., & Nicula, C. (2019). Antioxidant and anti-inflammatory effects of Curcumin nanoparticles on drug-induced acute myocardial infarction in diabetic rats. Antioxidants, 8(10), 504.","journal-title":"Antioxidants"},{"issue":"1","key":"1997_CR60","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1161\/HYPERTENSIONAHA.116.07237","volume":"68","author":"H. A. Itani","year":"2016","unstructured":"Itani, H. A., McMasterJr, W. G., Saleh, M. A., Nazarewicz, R. R., Mikolajczyk, T. P., & Kaszuba, A. M. (2016). Activation of human T cells in hypertension: Studies of humanized mice and hypertensive humans. Hypertension, 68(1), 123\u2013132.","journal-title":"Hypertension"},{"issue":"5","key":"1997_CR61","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1161\/HYPERTENSIONAHA.115.05779","volume":"66","author":"C. T. Chan","year":"2015","unstructured":"Chan, C. T., Sobey, C. G., Lieu, M., Ferens, D., Kett, M. M., & Diep, H. (2015). Obligatory role for B cells in the development of angiotensin II\u2013dependent hypertension. Hypertension, 66(5), 1023\u20131033.","journal-title":"Hypertension"},{"issue":"10","key":"1997_CR62","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1021\/acsanm.4c06510","volume":"8","author":"J. Hu","year":"2025","unstructured":"Hu, J., Ren, Q., Fan, D., Wu, W., Zhang, X., & Wang, D. (2025). Two-Dimensional nanozyme based on iron Metal\u2013Organic Gel\/Carboxylated graphene oxide for electrochemical and colorimetric Dual-Mode detection of hydrogen peroxide. ACS Applied Nano Materials, 8(10), 4989\u20135000.","journal-title":"ACS Applied Nano Materials"},{"key":"1997_CR63","first-page":"S27","volume":"178","author":"SP Alexander","year":"2021","unstructured":"Alexander, S. P., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., et al. (2021). The concise guide to PHARMACOLOGY 2021\/22: G protein-coupled receptors. British Journal of Pharmacology, 178, S27\u2013S156.","journal-title":"British Journal of Pharmacology"},{"issue":"6","key":"1997_CR64","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1080\/17435390.2021.1919329","volume":"15","author":"M Zhu","year":"2021","unstructured":"Zhu, M., Chen, H., Zhou, S., Zheng, L., Li, X., Chu, R., et al. (2021). Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload. Nanotoxicology, 15(6), 761\u2013778.","journal-title":"Nanotoxicology"},{"issue":"3","key":"1997_CR65","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1021\/bp049594q","volume":"21","author":"V. Ifandi","year":"2005","unstructured":"Ifandi, V., & Al-Rubeai, M. J. B. (2005). Regulation of cell proliferation and apoptosis in CHO\u2010K1 cells by the coexpression of c\u2010Myc and Bcl\u20102. Biotechnology progress, 21(3), 671\u2013677.","journal-title":"Biotechnology progress"},{"issue":"12","key":"1997_CR66","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1089\/ars.2009.2791","volume":"12","author":"M. M. Gallogly","year":"2010","unstructured":"Gallogly, M. M., Shelton, M. D., Qanungo, S., Pai, H. V., Starke, D. W., & Hoppel, C. L. (2010). Glutaredoxin regulates apoptosis in cardiomyocytes via NF\u03baB targets Bcl-2 and Bcl-xL: Implications for cardiac aging. Antioxidants & redox signaling, 12(12), 1339\u20131353.","journal-title":"Antioxidants & redox signaling"},{"key":"1997_CR67","first-page":"2633","volume":"25","author":"W. Liu","year":"2019","unstructured":"Liu, W., Ru, L., Su, C., Qi, S., Qi, X. J. M. S. M. I. M. J. E., & Research, C. (2019). Serum levels of inflammatory cytokines and expression of BCL2 and BAX mRNA in peripheral blood mononuclear cells and in patients with chronic heart failure. International Medical Journal of Experimental and Clinical Research, 25, 2633.","journal-title":"International Medical Journal of Experimental and Clinical Research"},{"issue":"2","key":"1997_CR68","first-page":"161","volume":"44","author":"N. Rathore","year":"2000","unstructured":"Rathore, N., Kale, M., & John, S. (2000). Bhatnagar DJIjop, pharmacology. Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat erythrocytes. Indian journal of physiology and pharmacology, 44(2), 161\u2013166.","journal-title":"Indian journal of physiology and pharmacology"},{"issue":"6","key":"1997_CR69","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1111\/trf.12485","volume":"54","author":"S. L. Spinelli","year":"2014","unstructured":"Spinelli, S. L., Lannan, K. L., Casey, A. E., Croasdell, A., Curran, T. M., & Henrichs, K. F. (2014). Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro. ransfusion, 54(6), 1569\u20131579.","journal-title":"ransfusion"},{"issue":"2","key":"1997_CR70","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/1076029614531449","volume":"21","author":"N. G. Kounis","year":"2015","unstructured":"Kounis, N. G., Soufras, G. D., Tsigkas, G., Hahalis, G. J. C., & Hemostasis, T., A (2015). White blood cell counts, leukocyte ratios, and eosinophils as inflammatory markers in patients with coronary artery disease. Clinical and Applied Thrombosis\/Hemostasis, 21(2), 139\u2013143.","journal-title":"Clinical and Applied Thrombosis\/Hemostasis"},{"key":"1997_CR71","doi-asserted-by":"crossref","unstructured":"Xie, M., Li, F., Li, Y., Qian, K., Liang, Y., Lei, B. (2025). Iron-doped carbon Dots nanozyme scavenged reactive oxygen species system for inhibiting effectively the uptake of arsenic in lettuce. Chemical Engineering Journal, 506, 159956.","DOI":"10.1016\/j.cej.2025.159956"},{"key":"1997_CR72","doi-asserted-by":"crossref","unstructured":"Mohammed, D., & Al-Habib, O. A. (2021). The effect of iron nanoparticles (FeNPs) on some biological and hematological parameters in albino rats. Indian Journal of Forensic Medicine & Toxicology. 15(3).","DOI":"10.37506\/ijfmt.v15i3.15727"},{"issue":"2","key":"1997_CR73","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s12011-023-03708-x","volume":"202","author":"EY Mohammady","year":"2024","unstructured":"Mohammady, E. Y., Elashry, M. A., Ibrahim, M. S., Elarian, M., Salem, S. M., El-Haroun, E. R., et al. (2024). Nano iron versus bulk iron forms as functional feed additives: growth, body indices, hematological assay, plasma metabolites, immune, anti-oxidative ability, and intestinal morphometric measurements of nile tilapia, Oreochromis niloticus. Biological Trace Element Research, 202(2), 787\u2013799.","journal-title":"Biological Trace Element Research"},{"issue":"7","key":"1997_CR74","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/jama.2017.21907","volume":"319","author":"E Fan","year":"2018","unstructured":"Fan, E., Brodie, D., & Slutsky, A. S. (2018). Acute respiratory distress syndrome: Advances in diagnosis and treatment. Jama, 319(7), 698\u2013710.","journal-title":"Jama"},{"issue":"1","key":"1997_CR75","doi-asserted-by":"publisher","first-page":"5228","DOI":"10.1038\/s41467-018-07657-1","volume":"9","author":"A Dhawan","year":"2018","unstructured":"Dhawan, A., Scott, J. G., Harris, A. L., & Buffa, F. M. (2018). Pan-cancer characterisation of MicroRNA across cancer hallmarks reveals MicroRNA-mediated downregulation of tumour suppressors. Nature Communications, 9(1), 5228.","journal-title":"Nature Communications"},{"issue":"1","key":"1997_CR76","doi-asserted-by":"publisher","first-page":"20240073","DOI":"10.1515\/chem-2024-0073","volume":"22","author":"C Yang","year":"2024","unstructured":"Yang, C., & Song, Z. (2024). Treatment of gestational diabetes by acroptilon repens leaf aqueous extract green-formulated iron nanoparticles in rats. Open Chemistry, 22(1), 20240073.","journal-title":"Open Chemistry"},{"issue":"1","key":"1997_CR77","first-page":"4687959","volume":"2023","author":"AK Mahor","year":"2023","unstructured":"Mahor, A. K., Singh, P. P., Gupta, R., Bhardwaj, P., Rathore, P., Kishore, A., et al. (2023). Nanostructured lipid carriers for improved delivery of therapeutics via the oral route. Journal of Nanotechnology, 2023(1), 4687959.","journal-title":"Journal of Nanotechnology"},{"key":"1997_CR78","doi-asserted-by":"crossref","unstructured":"Sharifiaghdam, Z., Amini, S. M., Dalouchi, F., Behrooz, A. B., & Azizi, Y. J. H. (2023). Apigenin-coated gold nanoparticles as a cardioprotective strategy against doxorubicin-induced cardiotoxicity in male rats via reducing apoptosis.Heliyon, 9(3).","DOI":"10.1016\/j.heliyon.2023.e14024"},{"key":"1997_CR79","doi-asserted-by":"crossref","unstructured":"Mohamed, A. T. A. E., Ragheb, M. A., Shehata, M. R., Mohamed, & ASJJoTEiM (2024). Biology. In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production. 86, 127516.","DOI":"10.1016\/j.jtemb.2024.127516"},{"issue":"3","key":"1997_CR80","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.cardiores.2006.11.031","volume":"73","author":"J. Niu","year":"2007","unstructured":"Niu, J., Azfer, A., Rogers, L. M., Wang, X., & Kolattukudy, P. E. J. C. (2007). Cardioprotective effects of cerium oxide nanoparticles in a Transgenic murine model of cardiomyopathy. Cardiovascular research, 73(3), 549\u2013559.","journal-title":"Cardiovascular research"},{"issue":"9","key":"1997_CR81","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.3390\/antibiotics11091252","volume":"11","author":"S. Z. Alshawwa","year":"2022","unstructured":"Alshawwa, S. Z., Mohammed, E. J., Hashim, N., Sharaf, M., Selim, S., & Alhuthali, H. M. (2022). In situ biosynthesis of reduced alpha hematite (\u03b1-Fe2O3) nanoparticles by stevia rebaudiana L. leaf extract: Insights into antioxidant, antimicrobial, and anticancer properties. Antibiotics, 11(9), 1252.","journal-title":"Antibiotics"},{"key":"1997_CR82","doi-asserted-by":"publisher","first-page":"106252","DOI":"10.1016\/j.pestbp.2024.106252","volume":"208","author":"Y. Guo","year":"2025","unstructured":"Guo, Y., Gan, Y., White, J. C., Zhang, X., Wei, D., & Liang, J. (2025). Fe2O3 nanoparticles enhance soybean resistance to root rot by modulating metabolic pathways and defense response. Pesticide Biochemistry and Physiology, 208, 106252.","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"1997_CR83","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jclepro.2018.01.127","volume":"180","author":"C. Xiao","year":"2018","unstructured":"Xiao, C., Li, J., & Zhang, G. J. J. C. P. (2018). Synthesis of stable burger-like \u03b1-Fe2O3 catalysts: Formation mechanism and excellent photo-Fenton catalytic performance. Journal of Cleaner Production, 180, 550\u2013559.","journal-title":"Journal of Cleaner Production"},{"issue":"20","key":"1997_CR84","doi-asserted-by":"publisher","first-page":"11744","DOI":"10.1039\/C4NR03275F","volume":"6","author":"Y. Qiu","year":"2014","unstructured":"Qiu, Y., Wang, Z., Owens, A. C., Kulaots, I., Chen, Y., & Kane, A. B. (2014). Antioxidant chemistry of graphene-based materials and its role in oxidation protection technology. Nanoscale, 6(20), 11744\u201311755.","journal-title":"Nanoscale"},{"issue":"1","key":"1997_CR85","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1038\/srep02484","volume":"3","author":"S. Zhou","year":"2013","unstructured":"Zhou, S., & Bongiorno, A. J. S. (2013). Origin of the chemical and kinetic stability of graphene oxide. Scientific reports, 3(1), 2484.","journal-title":"Scientific reports"},{"key":"1997_CR86","first-page":"595","volume":"42","author":"K. Bhattacharya","year":"2014","unstructured":"Bhattacharya, K., Gogoi, B., Buragohain, A., & Deb, P. J. M. S. (2014). C E. Fe2O3\/C nanocomposites having distinctive antioxidant activity and hemolysis prevention efficiency. The Lancet infectious diseases, 42, 595\u2013600.","journal-title":"The Lancet infectious diseases"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-01997-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-01997-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-01997-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:04:14Z","timestamp":1780484654000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-01997-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":86,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["1997"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-01997-2","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"5 January 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}