{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:52:16Z","timestamp":1789008736493,"version":"build-2803163510"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02017-z","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:19:47Z","timestamp":1771982387000},"page":"2545-2573","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fatty Acid-enriched Euphorbia neriifolia Alleviates the NPIP-induced Lung Cancer Via Modulating Oxidative Stress and Apoptosis in Swiss Albino Mice"],"prefix":"10.1007","volume":"84","author":[{"given":"Priya","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Meena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devendra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pracheta","family":"Janmeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2017_CR1","doi-asserted-by":"publisher","first-page":"9465","DOI":"10.3390\/ijerph18189465","volume":"18","author":"K Li","year":"2021","unstructured":"Li, K., Ricker, K., Tsai, F. C., Hsieh, C. J., Osborne, G., Sun, M., Marder, M. E., Elmore, S., Schmitz, R., & Sandy, M. S. (2021). Estimated cancer risks associated with nitrosamine contamination in commonly used medications. International Journal of Environmental Research and Public Health, 18, 9465. https:\/\/doi.org\/10.3390\/ijerph18189465","journal-title":"International Journal of Environmental Research and Public Health"},{"key":"2017_CR2","doi-asserted-by":"publisher","first-page":"1158198","DOI":"10.3389\/fchem.2023.1158198","volume":"11","author":"P Chaudhary","year":"2023","unstructured":"Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Razis, A., Modu, A. F., Calina, B., D., & Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11, 1158198. https:\/\/doi.org\/10.3389\/fchem.2023.1158198","journal-title":"Frontiers in Chemistry"},{"key":"2017_CR3","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.toxrep.2019.10.004","volume":"6","author":"SK Hassan","year":"2019","unstructured":"Hassan, S. K., Mousa, A. M., El-Sammad, N. M., Abdel-Halim, A. H., Khalil, W. K. B., Elsayed, E. A., Anwar, N., Linscheid, M. W., Moustafa, E. S., Hashim, A. N., & Nawwar, M. (2019). Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss albino mice. Toxicology Reports, 6, 1071\u20131085. https:\/\/doi.org\/10.1016\/j.toxrep.2019.10.004","journal-title":"Toxicology Reports"},{"key":"2017_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4103\/2319-4170.131378","volume":"37","author":"Y Xu","year":"2014","unstructured":"Xu, Y., & Y Qian, S. (2014). Anti-cancer activities of omega-6 polyunsaturated fatty acids. Biomedical Journal, 37, 112\u2013119. https:\/\/doi.org\/10.4103\/2319-4170.131378","journal-title":"Biomedical Journal"},{"key":"2017_CR5","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.3390\/su15021225","volume":"15","author":"P Chaudhary","year":"2023","unstructured":"Chaudhary, P., Singh, D., Swapnil, P., Meena, M., & Janmeda, P. (2023). Euphorbia neriifolia (Indian spurge tree): A plant of multiple biological and pharmacological activities. Sustainability, 15, 1225. https:\/\/doi.org\/10.3390\/su15021225","journal-title":"Sustainability"},{"key":"2017_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.5455\/spatula.20110414112919","volume":"1","author":"V Sharma","year":"2011","unstructured":"Sharma, V., Janmeda, P., & Singh, L. (2011). A review on Euphorbia neriifolia (Sehund). Spatulla DD, 1, 107\u2013111. https:\/\/doi.org\/10.5455\/spatula.20110414112919","journal-title":"Spatulla DD"},{"key":"2017_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.7324\/JABB.2022.100217","volume":"10","author":"P Chaudhary","year":"2022","unstructured":"Chaudhary, P., & Janmeda, P. (2022). Quantification of phytochemicals and in vitro antioxidant activities from various parts of Euphorbia neriifolia Linn. Journal of Applied Biology and Biotechnology, 10, 133\u2013145. https:\/\/doi.org\/10.7324\/JABB.2022.100217","journal-title":"Journal of Applied Biology and Biotechnology"},{"key":"2017_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4103\/0971-6580.111554","volume":"20","author":"V Sharma","year":"2013","unstructured":"Sharma, V., & Janmeda, P. (2013). Chemopreventive role of Euphorbia neriifolia (Linn) and its isolated flavonoid against N-nitrosodiethylamine-induced renal histopathological damage in male mice. Toxiclogy International, 20, 101\u2013107. https:\/\/doi.org\/10.4103\/0971-6580.111554","journal-title":"Toxiclogy International"},{"key":"2017_CR9","first-page":"521","volume":"50","author":"V Sharma","year":"2013","unstructured":"Sharma, V., & Janmeda, P. (2013). Anti-carcinogenic potential of Euphorbia neriifolia leaves and isolated flavonoid against N-nitrosodiethylamine-induced renal carcinogenesis in mice. Indian Journal of Biochemistry and Biophysics, 50, 521\u2013528.","journal-title":"Indian Journal of Biochemistry and Biophysics"},{"key":"2017_CR10","first-page":"183","volume":"4","author":"V Sharma","year":"2012","unstructured":"Sharma, V., Janmeda, P., Paliwal, R., Singh, S., Sharma, C., & Sharma, S. (2012). Elucidation of analgesic activity of hydroethanolic extract of Euphorbia neriifolia leaves in Swiss albino mice. Journal of Plant Development Sciences, 4, 183\u2013189.","journal-title":"Journal of Plant Development Sciences"},{"key":"2017_CR11","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3736\/jcim20121115","volume":"10","author":"V Sharma","year":"2012","unstructured":"Sharma, V., Janmeda, P., Paliwal, R., & Sharma, S. (2012). Antihepatotoxic activity of Euphorbia neriifolia extract against N-nitrosodiethylamine-induced hepatocarcinogenesis in mice. Zhong Xi Yi Jie He Xue Bao, 10, 1303\u20131309. https:\/\/doi.org\/10.3736\/jcim20121115","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"2017_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/0971-6580.128790","volume":"21","author":"V Sharma","year":"2014","unstructured":"Sharma, V., & Janmeda, P. (2014). Protective assessment of Euphorbia neriifolia and its isolated flavonoid against N-nitrosodiethylamine-induced hepatic carcinogenesis in male mice: A histopathological analysis. Toxicology International, 21, 37\u201343. https:\/\/doi.org\/10.4103\/0971-6580.128790","journal-title":"Toxicology International"},{"key":"2017_CR13","unstructured":"Jiang, S. (2011). The Inhibition of lung cancer active ingredient extracts of euphorbia lunulata and its mechanism. Ocean University of China: Qingdao, China."},{"key":"2017_CR14","doi-asserted-by":"publisher","unstructured":"Wang, Y., Yu, X., Wang, L., Zhang, F., & Zhang, Y. (2020). Research progress on chemical constituents and anticancer pharmacological activities of Euphorbia lunulata Bunge. Biomedical Research International, 2020, 3618941. https:\/\/doi.org\/10.1155\/2020\/3618941","DOI":"10.1155\/2020\/3618941"},{"key":"2017_CR15","first-page":"491","volume":"18","author":"F Gao","year":"2013","unstructured":"Gao, F., Fu, Z., Tian, H., & He, Z. (2013). The Euphorbia lunulata Bge extract inhibits proliferation of human hepatoma HepG2 cells and induces apoptosis. Journal of BUON, 18, 491\u2013495.","journal-title":"Journal of BUON"},{"key":"2017_CR16","doi-asserted-by":"publisher","unstructured":"Cheng, J., Han, W., Wang, Z., Shao, Y., Wang, Y., Zhang, Y., Li, Z., Xu, X., & Zhang, Y. (2015). Hepatocellular carcinoma growth is inhibited by Euphorbia helioscopia L. extract in nude mice Xenografts. Biomedical Research International, 2015, 601015. https:\/\/doi.org\/10.1155\/2015\/601015","DOI":"10.1155\/2015\/601015"},{"key":"2017_CR17","doi-asserted-by":"publisher","first-page":"559","DOI":"10.2174\/0115734110319220240718094750","volume":"21","author":"P Chaudhary","year":"2025","unstructured":"Chaudhary, P., Singh, D., Meena, M., & Janmeda, P. (2025). Extraction, isolation and characterization of bioactive compounds from Euphorbia neriifolia (L.) leaf and evaluation of their antioxidant activity. Current Analytical Chemistry, 21, 559\u2013574. https:\/\/doi.org\/10.2174\/0115734110319220240718094750","journal-title":"Current Analytical Chemistry"},{"key":"2017_CR18","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/jemt.24456","volume":"87","author":"P Chaudhary","year":"2023","unstructured":"Chaudhary, P., Meena, M., & Janmeda, P. (2023). Microscopic characterization, TLC fingerprinting and optimization of total lipid content from Euphorbia neriifolia (L.) using response surface methodology. Microscopy Research and Technique, 87, 565\u2013590. https:\/\/doi.org\/10.1002\/jemt.24456","journal-title":"Microscopy Research and Technique"},{"key":"2017_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.arabjc.2014.08.019","volume":"10","author":"V Sharma","year":"2017","unstructured":"Sharma, V., & Janmeda, P. (2017). Extraction, isolation and identification of flavonoid from Euphorbia neriifolia leaves. Arabian Journal of Chemistry, 10, 509\u2013514. https:\/\/doi.org\/10.1016\/j.arabjc.2014.08.019","journal-title":"Arabian Journal of Chemistry"},{"key":"2017_CR20","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2009","unstructured":"Trott, O., & Olson, A. (2009). Software news and update AutoDock vina: Improving the speed and accuracy of Docking with a new scoring function. Journal of Computational Chemistry, 31, 455\u2013461.","journal-title":"Journal of Computational Chemistry"},{"key":"2017_CR21","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7, 42717. https:\/\/doi.org\/10.1038\/srep42717","journal-title":"Scientific Reports"},{"key":"2017_CR22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s13205-019-1927-x","volume":"9","author":"G Kumar","year":"2019","unstructured":"Kumar, G., Gupta, R., Sharan, S., Roy, P., & Pandey, D. M. (2019). Anticancer activity of plant leaves extract collected from a tribal region of India. 3 Biotech, 9, 399. https:\/\/doi.org\/10.1007\/s13205-019-1927-x","journal-title":"3 Biotech"},{"key":"2017_CR23","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1016\/j.lfs.2004.05.015","volume":"75","author":"X Yin","year":"2004","unstructured":"Yin, X., Zhou, J., Jie, C., Xing, D., & Zhang, Y. (2004). Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sciences, 75, 2233\u20132244. https:\/\/doi.org\/10.1016\/j.lfs.2004.05.015","journal-title":"Life Sciences"},{"key":"2017_CR24","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1139\/O10-019","volume":"88","author":"XY Xie","year":"2010","unstructured":"Xie, X. Y., Shen, J., Xu, L. Y., Li, E. M., & Shen, Z. Y. (2010). Bronchogenic and alveologenic tumors in mice induced by N-nitrosopiperidine. Biochemistry and Cell Biology, 88, 775\u2013782. https:\/\/doi.org\/10.1139\/O10-019","journal-title":"Biochemistry and Cell Biology"},{"key":"2017_CR25","doi-asserted-by":"publisher","first-page":"72447","DOI":"10.18632\/oncotarget.19785","volume":"8","author":"Q Zhang","year":"2017","unstructured":"Zhang, Q., Li, R., Chen, X., Lee, S. B., Pan, J., Xiong, D., Hu, J., Miller, M. S., Szabo, E., Lubet, R. A., Wang, Y., & You, M. (2017). Effect of weekly or daily dosing regimen of gefitinib in mouse models of lung cancer. Oncotarget, 8, 72447\u201372456. https:\/\/doi.org\/10.18632\/oncotarget.19785","journal-title":"Oncotarget"},{"key":"2017_CR26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1476-511X-9-106","volume":"9","author":"X Lu","year":"2010","unstructured":"Lu, X., Yu, H., Ma, Q., Shen, S., & Das, U. N. (2010). Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. Lipids in Health and Disease, 9, 106. https:\/\/doi.org\/10.1186\/1476-511X-9-106","journal-title":"Lipids in Health and Disease"},{"key":"2017_CR27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3390\/medsci4010004","volume":"4","author":"I Bello","year":"2016","unstructured":"Bello, I., Bakkouri, A. S., Tabana, Y. M., Al-Hindi, B., Al-Mansoub, M. A., Mahmud, R., & Asmawi, M. Z. (2016). Acute and sub-acute toxicity evaluation of the methanolic extract of Alstonia scholaris stem bark. Medical Sciences (Basel), 4, 4. https:\/\/doi.org\/10.3390\/medsci4010004","journal-title":"Medical Sciences (Basel)"},{"key":"2017_CR28","doi-asserted-by":"publisher","first-page":"e00661","DOI":"10.1016\/j.heliyon.2018.e00661","volume":"4","author":"D Kumar","year":"2018","unstructured":"Kumar, D., Sharma, P., Nepali, K., Mahajan, G., Mintoo, M. J., Singh, A., Singh, G., Mondhe, D. M., Singh, G., Jain, S. K., Gupta, G. K., & Ntie-Kang, F. (2018). Antitumour, acute toxicity and molecular modeling studies of 4-(pyridin-4-yl)-6-(thiophen-2-yl) pyrimidin-2(1H)-one against Ehrlich ascites carcinoma and sarcoma-180. Heliyon, 4, e00661. https:\/\/doi.org\/10.1016\/j.heliyon.2018.e00661","journal-title":"Heliyon"},{"key":"2017_CR29","unstructured":"King, J. (1965). Practical clinical enzymology (p. 363). D. Van Nostrand Company."},{"key":"2017_CR30","unstructured":"Bergmeyer, H. U. (2012). Methods of enzymatic analysis. Elsevier."},{"key":"2017_CR31","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/0005-2736(72)90352-5","volume":"282","author":"P Luly","year":"1972","unstructured":"Luly, P., Barnabei, O., & Tria, E. (1972). Hormonal control in vitro of plasma membrane-bound (Na+-K+)-ATPase of rat liver. Biochimica Et Biophysica Acta, 282, 447\u2013452. https:\/\/doi.org\/10.1016\/0005-2736(72)90352-5","journal-title":"Biochimica Et Biophysica Acta"},{"key":"2017_CR32","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa, H., Ohishi, N., & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal in Biochemistry, 95, 351\u2013358. https:\/\/doi.org\/10.1016\/0003-2697(79)90738-3","journal-title":"Anal in Biochemistry"},{"key":"2017_CR33","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund, S., & Marklund, G. (1974). Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry, 47, 469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"European Journal of Biochemistry"},{"key":"2017_CR34","doi-asserted-by":"crossref","unstructured":"Aebi,H. (1984). [13] catalase in vitro. Lester Packer (Ed.), Methods in enzymology (pp. 121\u2013126). Elsevier. https:\/\/www.sciencedirect.com\/bookseries\/methods-in-enzymology\/vol\/105\/suppl\/C","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"2017_CR35","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1016\/0006-2952(84)90353-8","volume":"33","author":"J Mohandas","year":"1984","unstructured":"Mohandas, J., Marshall, J. J., Duggin, G. G., Horvath, J. S., & Tiller, D. J. (1984). Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Possible implications in analgesic nephropathy. Biochemical Pharmacology, 33, 1801\u20131807. https:\/\/doi.org\/10.1016\/0006-2952(84)90353-8","journal-title":"Biochemical Pharmacology"},{"key":"2017_CR36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry, O. H., Rosebrough, N. J., Farr, A. L., & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265\u2013275.","journal-title":"Journal of Biological Chemistry"},{"key":"2017_CR37","doi-asserted-by":"crossref","unstructured":"Omaye, S. T., Turnbull, J. D., & Sauberlich, H. E. (1979). Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Donald B. McCormick, Lemuel D. Wright (Eds.), Methods in Enzymology (pp. 3-11). Elsevier.","DOI":"10.1016\/0076-6879(79)62181-X"},{"key":"2017_CR38","doi-asserted-by":"crossref","unstructured":"Desai, I. D. (1984). Vitamin E analysis methods for animal tissues. In Methods in Enzymology, pp 138\u2013147, Elsevier.","DOI":"10.1016\/S0076-6879(84)05019-9"},{"key":"2017_CR39","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1016\/S0021-9258(18)69851-5","volume":"234","author":"L Warren","year":"1959","unstructured":"Warren, L. (1959). The thiobarbituric acid assay of Sialic acids. Journal of Biological Chemistry, 234, 1971\u20131975.","journal-title":"Journal of Biological Chemistry"},{"key":"2017_CR40","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/0009-8981(72)90105-2","volume":"42","author":"P Niebes","year":"1972","unstructured":"Niebes, P. (1972). Determination of enzymes and degradation products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects. Clinica Chimica Acta, 42, 399\u2013408.","journal-title":"Clinica Chimica Acta"},{"key":"2017_CR41","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0003-2697(79)90379-8","volume":"94","author":"WD Wagner","year":"1979","unstructured":"Wagner, W. D. (1979). A more sensitive assay discriminating galactosamine and glucosamine in mixtures. Analytical Biochemistry, 94, 394\u2013396. https:\/\/doi.org\/10.1016\/0003-2697(79)90379-8","journal-title":"Analytical Biochemistry"},{"key":"2017_CR42","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/0003-2697(62)90095-7","volume":"4","author":"T Bitter","year":"1962","unstructured":"Bitter, T., & Muir, H. M. (1962). A modified uronic acid carbazole reaction. Anal in Biochemistry, 4, 330\u2013334. https:\/\/doi.org\/10.1016\/0003-2697(62)90095-7","journal-title":"Anal in Biochemistry"},{"key":"2017_CR43","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.7314\/apjcp.2013.14.3.1833","volume":"14","author":"VV Prabhu","year":"2013","unstructured":"Prabhu, V. V., & Guruvayoorappan, C. (2013). Inhibition of metastatic lung cancer in C57BL\/6 mice by marine Mangrove Rhizophora apiculata. Asian Pacific Journal of Cancer Prevention, 14, 1833\u20131840. https:\/\/doi.org\/10.7314\/apjcp.2013.14.3.1833","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"2017_CR44","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3390\/life12020303","volume":"12","author":"MJ Kim","year":"2022","unstructured":"Kim, M. J., Kawk, H. W., Kim, S. H., Lee, H. J., Seo, J. W., Lee, C. Y., & Kim, Y. M. (2022). The p53-driven anticancer effect of Ribes fasciculatum extract on AGS gastric cancer cells. Life (Basel), 12, 303. https:\/\/doi.org\/10.3390\/life12020303","journal-title":"Life (Basel)"},{"key":"2017_CR45","doi-asserted-by":"publisher","first-page":"771","DOI":"10.22034\/APJCP.2017.18.3.771","volume":"18","author":"ZI Al-Faifi","year":"2017","unstructured":"Al-Faifi, Z. I., Masrahi, Y. S., Aly, M. S., Al-Turki, T. A., & Dardeer, T. (2017). Evaluation of cytotoxic and genotoxic effects of Euphorbia triaculeata Forssk. extract. Asian Pacific Journal of Cancer Prevention, 18, 771\u2013777. https:\/\/doi.org\/10.22034\/APJCP.2017.18.3.771","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"2017_CR46","doi-asserted-by":"publisher","first-page":"559","DOI":"10.2174\/0115734110319220240718094750","volume":"21","author":"P Chaudhary","year":"2025","unstructured":"Chaudhary, P., Singh, D., Meena, M., & Janmeda, P. (2025). Extraction, isolation and characterization of bioactive compounds from Euphorbia neriifolia (L.) leaf and evaluation of their antioxidant activity. Current Analytical Chemistry, 21, 559\u2013574.","journal-title":"Current Analytical Chemistry"},{"key":"2017_CR47","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1126\/science.aba8984","volume":"369","author":"D Guan","year":"2020","unstructured":"Guan, D., Xiong, Y., Trinh, T. M., Xiao, Y., Hu, W., Jiang, C., Dierickx, P., Jang, C., Rabinowitz, J. D., & Lazar, M. A. (2020). The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science, 369, 1388\u20131394. https:\/\/doi.org\/10.1126\/science.aba8984","journal-title":"Science"},{"key":"2017_CR48","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/cpt.1672","volume":"107","author":"C Fink","year":"2020","unstructured":"Fink, C., Sun, D., Wagner, K., Schneider, M., Bauer, H., Dolgos, H., Mader, K., & Peters, S. A. (2020). Evaluating the role of solubility in oral absorption of poorly water-soluble drugs using physiologically-based pharmacokinetic modeling. Clinical Pharmacology and Therapeutics, 107, 650\u2013661. https:\/\/doi.org\/10.1002\/cpt.1672","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"2017_CR49","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.3390\/molecules25051135","volume":"25","author":"J Bojarska","year":"2020","unstructured":"Bojarska, J., Remko, M., Breza, M., Madura, I. D., Kaczmarek, K., Zabrocki, J., & Wolf, W. M. (2020). A supramolecular approach to structure-based design with a focus on synthons hierarchy in ornithine-derived ligands: Review, synthesis, experimental and in Silico studies. Molecules, 25, 1135. https:\/\/doi.org\/10.3390\/molecules25051135","journal-title":"Molecules"},{"key":"2017_CR50","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/01635581.2019.1613552","volume":"72","author":"M Mielczarek-Puta","year":"2020","unstructured":"Mielczarek-Puta, M., Otto-Slusarczyk, D., Chrzanowska, A., Filipek, A., & Grabon, W. (2020). Telmisartan influences the antiproliferative activity of linoleic acid in human colon cancer cells. Nutrition and Cancer, 72, 98\u2013109. https:\/\/doi.org\/10.1080\/01635581.2019.1613552","journal-title":"Nutrition and Cancer"},{"key":"2017_CR51","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.4103\/0973-1482.137966","volume":"10","author":"P Rajendran","year":"2014","unstructured":"Rajendran, P., Rengarajan, T., Nishigaki, I., Ekambaram, G., & Sakthisekaran, D. (2014). Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice. Journal of Cancer Research and Therapeutics, 10, 1033\u20131039. https:\/\/doi.org\/10.4103\/0973-1482.137966","journal-title":"Journal of Cancer Research and Therapeutics"},{"key":"2017_CR52","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fphys.2018.00113","volume":"9","author":"C Rosales","year":"2018","unstructured":"Rosales, C. (2018). Neutrophil: A cell with many roles in inflammation or several cell types? Frontiers in Physiology, 9, 113. https:\/\/doi.org\/10.3389\/fphys.2018.00113","journal-title":"Frontiers in Physiology"},{"key":"2017_CR53","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3109\/02841869009126536","volume":"29","author":"T Encan","year":"1990","unstructured":"Encan, T., & Hannisdal, E. (1990). Blood analyses as prognostic factors in primary lung cancer. Acta Oncologica, 29, 151\u2013154.","journal-title":"Acta Oncologica"},{"key":"2017_CR54","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1172\/JCI109201","volume":"62","author":"J Donofrio","year":"1978","unstructured":"Donofrio, J., Coleman, M. S., Hutton, J. J., Daoud, A., Lampkin, B., & Dyminski, J. (1978). Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease. Journal of Clinical Investigation, 62, 884\u2013887. https:\/\/doi.org\/10.1172\/JCI109201","journal-title":"Journal of Clinical Investigation"},{"key":"2017_CR55","first-page":"275","volume":"31","author":"A Vanisree","year":"1999","unstructured":"Vanisree, A., & Shyamaladevi, C. (1999). Effect of therapeutic strategy established by N-acetylcysteine and vitamin C on the activities of tumour marker enzymes in vitro. Indian Journal of Pharmacology, 31, 275\u2013278.","journal-title":"Indian Journal of Pharmacology"},{"key":"2017_CR56","first-page":"39","volume":"29","author":"G Ramakrishnan","year":"2007","unstructured":"Ramakrishnan, G., Augustine, T. A., Jagan, S., Vinodhkumar, R., & Devaki, T. (2007). Effect of Silymarin on N-nitrosodiethylamine induced hepatocarcinogenesis in rats. Experimental Oncology, 29, 39\u201344.","journal-title":"Experimental Oncology"},{"key":"2017_CR57","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1152\/physrev.00010.2014","volume":"96","author":"XG Lei","year":"2016","unstructured":"Lei, X. G., Zhu, J. H., Cheng, W. H., Bao, Y., Ho, Y. S., Reddi, A. R., Holmgren, A., & Arner, E. S. (2016). Paradoxical roles of antioxidant enzymes: Basic mechanisms and health implications. Physiological Reviews, 96, 307\u2013364. https:\/\/doi.org\/10.1152\/physrev.00010.2014","journal-title":"Physiological Reviews"},{"key":"2017_CR58","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.bionut.2014.08.001","volume":"4","author":"R Venugopal","year":"2014","unstructured":"Venugopal, R., Mahesh, V., Ekambaram, G., Aadithya, A., & Sakthisekaran, D. (2014). Protective role of Solanum trilobatum (Solanaeace) against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Biomedicine & Preventive Nutrition, 4, 535\u2013541.","journal-title":"Biomedicine & Preventive Nutrition"},{"key":"2017_CR59","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.pupt.2005.04.002","volume":"19","author":"K Selvendiran","year":"2006","unstructured":"Selvendiran, K., Prince Vijeya Singh, J., & Sakthisekaran, D. (2006). In vivo effect of Piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pulmonary Pharmacology and Therapeutics, 19, 107\u2013111. https:\/\/doi.org\/10.1016\/j.pupt.2005.04.002","journal-title":"Pulmonary Pharmacology and Therapeutics"},{"key":"2017_CR60","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nrc1649","volume":"5","author":"MM Fuster","year":"2005","unstructured":"Fuster, M. M., & Esko, J. D. (2005). The sweet and sour of cancer: Glycans as novel therapeutic targets. Nature Reviews Cancer, 5, 526\u2013542. https:\/\/doi.org\/10.1038\/nrc1649","journal-title":"Nature Reviews Cancer"},{"key":"2017_CR61","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/s0959-8049(00)00448-2","volume":"37","author":"P Lipponen","year":"2001","unstructured":"Lipponen, P., Aaltomaa, S., Tammi, R., Tammi, M., Agren, U., & Kosma, V. M. (2001). High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer. European Journal of Cancer, 37, 849\u2013856. https:\/\/doi.org\/10.1016\/s0959-8049(00)00448-2","journal-title":"European Journal of Cancer"},{"key":"2017_CR62","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1756-9966-30-87","volume":"30","author":"RS Wong","year":"2011","unstructured":"Wong, R. S. (2011). Apoptosis in cancer: From pathogenesis to treatment. Journal of Experimental and Clinical Cancer Research, 30, 87. https:\/\/doi.org\/10.1186\/1756-9966-30-87","journal-title":"Journal of Experimental and Clinical Cancer Research"},{"key":"2017_CR63","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1471-2121-14-32","volume":"14","author":"M Brentnall","year":"2013","unstructured":"Brentnall, M., Rodriguez-Menocal, L., De Guevara, R. L., Cepero, E., & Boise, L. H. (2013). Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biology, 14, 32. https:\/\/doi.org\/10.1186\/1471-2121-14-32","journal-title":"BMC Cell Biology"},{"key":"2017_CR64","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1159\/000329064","volume":"80","author":"AB Nanguzgambo","year":"2011","unstructured":"Nanguzgambo, A. B., Razack, R., Louw, M., & Bolliger, C. T. (2011). Immunochemistry and lung cancer: Application in diagnosis, prognosis and targeted therapy. Oncology (Williston Park, N.Y.), 80, 247\u2013256. https:\/\/doi.org\/10.1159\/000329064","journal-title":"Oncology (Williston Park, N.Y.)"},{"key":"2017_CR65","doi-asserted-by":"publisher","first-page":"e12708","DOI":"10.1111\/jfbc.12708","volume":"43","author":"S Liu","year":"2019","unstructured":"Liu, S., Sui, Q., Zou, J., Zhao, Y., & Chang, X. (2019). Protective effects of Hawthorn (Crataegus pinnatifida) polyphenol extract against UVB-induced skin damage by modulating the p53 mitochondrial pathway in vitro and in vivo. Journal of Food Biochemistry, 43, e12708. https:\/\/doi.org\/10.1111\/jfbc.12708","journal-title":"Journal of Food Biochemistry"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02017-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02017-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02017-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:22:39Z","timestamp":1780482159000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02017-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2017"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02017-z","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"31 January 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}