{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:40:32Z","timestamp":1790181632072,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hospital fund of the First Hospital of Lanzhou University","award":["ldyyyn2023-115"],"award-info":[{"award-number":["ldyyyn2023-115"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260010"],"award-info":[{"award-number":["82260010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research and Development Program of Gansu Province","award":["22YF7FA083"],"award-info":[{"award-number":["22YF7FA083"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02048-6","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:51:22Z","timestamp":1773215482000},"page":"3011-3021","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Andrographolide Alleviates Inflammation in Chronic Obstructive Pulmonary Disease by Inhibiting Alveolar Macrophage Pyroptosis Through the JNK\/NLRP3 Pathway"],"prefix":"10.1007","volume":"84","author":[{"given":"Tingting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"2048_CR1","doi-asserted-by":"publisher","first-page":"eabj5761","DOI":"10.1126\/sciimmunol.abj5761","volume":"7","author":"F Li","year":"2022","unstructured":"Li, F., Piattini, F., Pohlmeier, L., Feng, Q., Rehrauer, H., & Kopf, M. (2022). Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection. Science Immunology, 7(73), eabj5761. https:\/\/doi.org\/10.1126\/sciimmunol.abj5761","journal-title":"Sci Immunol"},{"issue":"11","key":"2048_CR2","doi-asserted-by":"publisher","first-page":"5631","DOI":"10.3390\/ijms25115631","volume":"25","author":"G. D. Kim","year":"2024","unstructured":"Kim, G. D., Lim, E. Y., & Shin, H. S. (2024). Macrophage Polarization and Functions in Pathogenesis of Chronic Obstructive Pulmonary Disease. International Journal Of Molecular Sciences, 25(11), 5631. https:\/\/doi.org\/10.3390\/ijms25115631","journal-title":"International Journal Of Molecular Sciences"},{"key":"2048_CR3","doi-asserted-by":"publisher","first-page":"109293","DOI":"10.1016\/j.clim.2023.109293","volume":"250","author":"S He","year":"2023","unstructured":"He, S., Zhang, X., Yao, Q., Chen, Q., Liu, B., Liao, L., Gong, Y., Yang, H., & Wang, D. (2023). PPAR\u03b3 inhibits small airway remodeling through mediating the polarization homeostasis of alveolar macrophages in COPD. Clinical Immunology (Orlando, Fla.), 250, 109293. https:\/\/doi.org\/10.1016\/j.clim.2023.109293","journal-title":"Clin Immunol"},{"key":"2048_CR4","doi-asserted-by":"publisher","first-page":"107035","DOI":"10.1016\/j.rmed.2022.107035","volume":"205","author":"J Wu","year":"2022","unstructured":"Wu, J.,Zhao, X., Xiao, C., Xiong, G., Ye, X., Li, L., Fang, Y., Chen, H., Yang, W., & Du, X. (2022). The role of lung macrophages in chronic obstructive pulmonary disease. Respiratory Medicine, 205, 107035. https:\/\/doi.org\/10.1016\/j.rmed.2022.107035","journal-title":"Respiratory Medicine"},{"issue":"11","key":"2048_CR5","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.3390\/ijms20112785","volume":"20","author":"P. Henrot","year":"2019","unstructured":"Henrot, P., Prevel, R., Berger, P., & Dupin, I. (2019). Chemokines in COPD: From Implication to Therapeutic Use. International Journal Of Molecular Sciences, 20(11), 2785. https:\/\/doi.org\/10.3390\/ijms20112785","journal-title":"International Journal Of Molecular Sciences"},{"key":"2048_CR6","doi-asserted-by":"publisher","unstructured":"Kapellos, T. S., Bassler, K., Aschenbrenner, A. C., Fujii, W., & Schultze, J. L. (2018). Dysregulated Functions of Lung Macrophage Populations in COPD. Journal of immunology research, 2018, 2349045 https:\/\/doi.org\/10.1155\/2018\/2349045","DOI":"10.1155\/2018\/2349045"},{"key":"2048_CR7","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","volume":"42","author":"J Shi","year":"2017","unstructured":"Shi, J.,Gao, W., & Shao, F. (2017). Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death. Trends In Biochemical Sciences, 42(4), 245\u2013254. https:\/\/doi.org\/10.1016\/j.tibs.2016.10.004","journal-title":"Trends In Biochemical Sciences"},{"key":"2048_CR8","doi-asserted-by":"publisher","first-page":"920464","DOI":"10.3389\/fimmu.2022.920464","volume":"13","author":"J. Sun","year":"2022","unstructured":"Sun, J., & Li, Y. (2022). Pyroptosis and respiratory diseases: A review of current knowledge. Frontiers In Immunology, 13, 920464. https:\/\/doi.org\/10.3389\/fimmu.2022.920464","journal-title":"Frontiers In Immunology"},{"key":"2048_CR9","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s13105-022-00909-1","volume":"78","author":"Y Feng","year":"2022","unstructured":"Feng, Y., Li, M., Yangzhong, X., Zhang, X., Zu, A., Hou, Y., Li, L., & Sun, S. (2022). Pyroptosis in inflammation-related respiratory disease. Journal Of Physiology And Biochemistry, 78(4), 721\u2013737. https:\/\/doi.org\/10.1007\/s13105-022-00909-1","journal-title":"Journal Of Physiology And Biochemistry"},{"key":"2048_CR10","doi-asserted-by":"publisher","first-page":"136740","DOI":"10.1016\/j.jhazmat.2024.136740","volume":"484","author":"M Zhang","year":"2025","unstructured":"Zhang, M., Lan, H., Jiang, M., Yang, M., Chen, H., Peng, S., Wang, X., Zhang, Y., Huang, X., Li, L., Chen, C., & Hong, J. (2025). NLRP3 inflammasome mediates pyroptosis of alveolar macrophages to induce radiation lung injury. Journal Of Hazardous Materials, 484, 136740. https:\/\/doi.org\/10.1016\/j.jhazmat.2024.136740","journal-title":"Journal Of Hazardous Materials"},{"key":"2048_CR11","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s10753-021-01494-z","volume":"44","author":"X Chen","year":"2021","unstructured":"Chen, X.,Xiao, Z., Jiang, Z., Jiang, Y., Li, W., & Wang, M. (2021). Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis. Inflammation, 44(6), 2217\u20132231. https:\/\/doi.org\/10.1007\/s10753-021-01494-z","journal-title":"Inflammation"},{"key":"2048_CR12","doi-asserted-by":"publisher","first-page":"682","DOI":"10.18632\/genesandcancer.155","volume":"8","author":"DN Dhanasekaran","year":"2017","unstructured":"Dhanasekaran, D. N., & Reddy, E. P. (2017). JNK-signaling: A multiplexing hub in programmed cell death. Genes & Cancer, 8(9-10), 682\u2013694. https:\/\/doi.org\/10.18632\/genesandcancer.155","journal-title":"Genes Cancer"},{"key":"2048_CR13","doi-asserted-by":"publisher","first-page":"154574","DOI":"10.1016\/j.phymed.2022.154574","volume":"109","author":"X. Wang","year":"2023","unstructured":"Wang, X., Wu, F. P., Huang, Y. R., Li, H. D., Cao, X. Y., You, Y., Meng, Z. F., Sun, K. Y., & Shen, X. Y. (2023). Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2\/JNK\/SREBP2 pathway in sepsis. Phytomedicine, 109, 154574. https:\/\/doi.org\/10.1016\/j.phymed.2022.154574","journal-title":"Phytomedicine"},{"key":"2048_CR14","doi-asserted-by":"publisher","first-page":"107962","DOI":"10.1016\/j.intimp.2021.107962","volume":"99","author":"J He","year":"2021","unstructured":"He, J., Liu, T., Li, Y., Mi, X., Han, D., Yang, N., Chen, L., Li, Y., Hong, J., Kuang, C., Yuan, Y., Cao, Y., Han, Y., Shi, C., Li, Z., & Guo, X. (2021). JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. International Immunopharmacology, 99, 107962. https:\/\/doi.org\/10.1016\/j.intimp.2021.107962","journal-title":"International Immunopharmacology"},{"key":"2048_CR15","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1165\/rcmb.2015-0195OC","volume":"56","author":"IMJ Eurlings","year":"2017","unstructured":"Eurlings, I. M., Reynaert, N. L., van de Wetering, C., Aesif, S. W., Mercken, E. M., de Cabo, R., van der Velden, J. L., Janssen-Heininger, Y. M., Wouters, E. F., & Dentener, M. A. (2017). Involvement of c-Jun N-Terminal Kinase in TNF-\u03b1\u2013Driven Remodeling. American Journal Of Respiratory Cell And Molecular Biology, 56 (3), 393\u2013401. https:\/\/doi.org\/10.1165\/rcmb.2015-0195OC","journal-title":"American Journal Of Respiratory Cell And Molecular Biology"},{"key":"2048_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.molimm.2023.10.007","volume":"163","author":"Z Zhao","year":"2023","unstructured":"Zhao, Z.,Tong, Y., Kang, Y., Qiu, Z., Li, Q., Xu, C., Wu, G., Jia, W., & Wang, P. (2023). Sodium butyrate (SB) ameliorated inflammation of COPD induced by cigarette smoke through activating the GPR43 to inhibit NF-\u03baB\/MAPKs signaling pathways. Molecular Immunology, 163, 224\u2013234. https:\/\/doi.org\/10.1016\/j.molimm.2023.10.007","journal-title":"Molecular Immunology"},{"key":"2048_CR17","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1002\/ptr.7905","volume":"37","author":"H Feng","year":"2023","unstructured":"Feng, H., Zhang, D., Yin, Y., Kang, J., & Zheng, R. (2023). Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK\/c-Jun. Phytotherapy Research, 37(9), 4251\u20134264. https:\/\/doi.org\/10.1002\/ptr.7905","journal-title":"Phytotherapy Research"},{"key":"2048_CR18","doi-asserted-by":"publisher","first-page":"920435","DOI":"10.3389\/fphar.2022.920435","volume":"13","author":"X Li","year":"2022","unstructured":"Li, X.,Yuan, W., Wu, J., Zhen, J., Sun, Q., & Yu, M. (2022). Andrographolide, a natural anti-inflammatory agent: An Update. Frontiers In Pharmacology, 13, 920435. https:\/\/doi.org\/10.3389\/fphar.2022.920435","journal-title":"Frontiers In Pharmacology"},{"key":"2048_CR19","doi-asserted-by":"publisher","first-page":"113646","DOI":"10.1016\/j.bcp.2019.113646","volume":"170","author":"N Kim","year":"2019","unstructured":"Kim, N.,Lertnimitphun, P., Jiang, Y., Tan, H., Zhou, H., Lu, Y., & Xu, H. (2019). Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK. Biochemical Pharmacology, 170, 113646. https:\/\/doi.org\/10.1016\/j.bcp.2019.113646","journal-title":"Biochemical Pharmacology"},{"key":"2048_CR20","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41419-019-2195-8","volume":"10","author":"J Gao","year":"2019","unstructured":"Gao, J., Peng, S., Shan, X., Deng, G., Shen, L., Sun, J., Jiang, C., Yang, X., Chang, Z., Sun, X., Feng, F., Kong, L., Gu, Y., Guo, W., Xu, Q., & Sun, Y.(2019). Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell Death & Disease, 10(12), 957. https:\/\/doi.org\/10.1038\/s41419-019-2195-8","journal-title":"Cell Death And Disease"},{"key":"2048_CR21","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.etap.2016.10.006","volume":"48","author":"X Chu","year":"2016","unstructured":"Chu, X., Liu, X. J., Qiu, J. M., Zeng, X. L., Bao, H. R., & Shu, J. (2016). Effects of Astragalus and Codonopsis pilosula polysaccharides on alveolar macrophage phagocytosis and inflammation in chronic obstructive pulmonary disease mice exposed to PM2.5. Environmental Toxicology And Pharmacology, 48, 76\u201384. https:\/\/doi.org\/10.1016\/j.etap.2016.10.006","journal-title":"Environmental Toxicology And Pharmacology"},{"key":"2048_CR22","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/jbt.21483","volume":"27","author":"D Yang","year":"2013","unstructured":"Yang, D., Zhang, W., Song, L., & Guo, F. (2013). Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1. Journal Of Biochemical And Molecular Toxicology, 27(5), 259\u2013265. https:\/\/doi.org\/10.1002\/jbt.21483","journal-title":"Journal Of Biochemical And Molecular Toxicology"},{"key":"2048_CR23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1080\/01902148.2021.1933653","volume":"47","author":"Z He","year":"2021","unstructured":"He, Z., Wu, J., Zeng, X., Bao, H., & Liu, X. (2021). Role of the Notch ligands Jagged1 and Delta4 in Th17\/Treg immune imbalance in a mouse model of chronic asthma. Experimental Lung Research, 47(6), 289\u2013299. https:\/\/doi.org\/10.1080\/01902148.2021.1933653","journal-title":"Experimental Lung Research"},{"key":"2048_CR24","doi-asserted-by":"publisher","first-page":"e31944","DOI":"10.1097\/MD.0000000000031944","volume":"101","author":"XL Zeng","year":"2022","unstructured":"Zeng, X. L., Yang, X. N., & Liu, X. J. (2022). Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a\/SIRT1\/NF-\u03baB pathway. Medicine (Baltimore), 101(46), e31944. https:\/\/doi.org\/10.1097\/MD.0000000000031944","journal-title":"Medicine (Baltimore)"},{"key":"2048_CR25","doi-asserted-by":"publisher","first-page":"110104","DOI":"10.1016\/j.intimp.2023.110104","volume":"118","author":"YT Wu","year":"2023","unstructured":"Wu, Y. T., Xu, W. T., Zheng, L., Wang, S., Wei, J., Liu, M. Y., Zhou, H. P., Li, Q. F., Shi, X., & Lv, X. (2023). 4-octyl itaconate ameliorates alveolar macrophage pyroptosis against ARDS via rescuing mitochondrial dysfunction and suppressing the cGAS\/STING pathway. International Immunopharmacology, 118, 110104. https:\/\/doi.org\/10.1016\/j.intimp.2023.110104","journal-title":"International Immunopharmacology"},{"issue":"1","key":"2048_CR26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12931-022-01926-w","volume":"23","author":"Z. Zhu","year":"2022","unstructured":"Zhu, Z., Lian, X., Su, X., Wu, W., Zeng, Y., & Chen, X. (2022). Exosomes derived from adipose-derived stem cells alleviate cigarette smoke-induced lung inflammation and injury by inhibiting alveolar macrophages pyroptosis. Respiratory Research, 23(1), 5. https:\/\/doi.org\/10.1186\/s12931-022-01926-w","journal-title":"Respiratory Research"},{"key":"2048_CR27","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.2147\/DDDT.S445788","volume":"18","author":"Y Yu","year":"2024","unstructured":"Yu, Y., Miao, T. W., Xiao, W., Mao, B., Du, L. Y., Wang, Y., & Fu, J. J. (2024). Andrographolide Attenuates NLRP3 Inflammasome Activation and Airway Inflammation in Exacerbation of Chronic Obstructive Pulmonary Disease. Drug Design, Development And Therapy, 18, 1755\u20131770. https:\/\/doi.org\/10.2147\/DDDT.S445788","journal-title":"Drug Design, Development And Therapy"},{"key":"2048_CR28","doi-asserted-by":"publisher","first-page":"7544","DOI":"10.1038\/s41598-022-11164-1","volume":"12","author":"I Markeli\u0107","year":"2022","unstructured":"Markeli\u0107, I., Hlap\u010di\u0107, I., \u010ceri, A., Radi\u0107 Antolic, M., Samar\u017eija, M., Popovi\u0107-Grle, S., Vuki\u0107 Dugac, A., & Rumora, L. (2022). Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease. Scientific Reports, 12(1), 7544. https:\/\/doi.org\/10.1038\/s41598-022-11164-1","journal-title":"Scientific Reports"},{"key":"2048_CR29","doi-asserted-by":"publisher","first-page":"119090","DOI":"10.1016\/j.lfs.2021.119090","volume":"269","author":"MY Zhang","year":"2021","unstructured":"Zhang, M. Y., Jiang, Y. X., Yang, Y. C., Liu, J. Y., Huo, C., Ji, X. L., & Qu, Y. Q. (2021). Cigarette smoke extract induces pyroptosis in human bronchial epithelial cells through the ROS\/NLRP3\/caspase-1 pathway. Life Sciences, 269, 119090. https:\/\/doi.org\/10.1016\/j.lfs.2021.119090","journal-title":"Life Sciences"},{"key":"2048_CR30","doi-asserted-by":"publisher","first-page":"115047","DOI":"10.1016\/j.biopha.2023.115047","volume":"165","author":"X Fan","year":"2023","unstructured":"Fan, X., Gao, Y., Hua, C., Peng, L., & Ci, X. (2023). Daphnetin ameliorates PM2.5-induced airway inflammation by inhibiting NLRP3 inflammasome-mediated pyroptosis in CS-exposed mice. Biomedicine & Pharmacotherapy, 165, 115047. https:\/\/doi.org\/10.1016\/j.biopha.2023.115047","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1","key":"2048_CR31","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10787-025-02083-4","volume":"34","author":"V. P. Samuel","year":"2025","unstructured":"Samuel, V. P., Afzal, M., Babu, M. A., Malathi, H., Maharana, L., Pandey, S. N., Ali, H., Almalki, W. H., Almujri, S. S., & Kumar, K. B. (2025). Targeting gasdermin D\u2013mediated pyroptosis: a precision anti-inflammatory strategy for acute and chronic lung diseases. Inflammopharmacology, 34(1), 181\u2013203. https:\/\/doi.org\/10.1007\/s10787-025-02083-4","journal-title":"Inflammopharmacology"},{"key":"2048_CR32","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molcel.2017.08.017","volume":"68","author":"N Song","year":"2017","unstructured":"Song, N., Liu, Z. S., Xue, W., Bai, Z. F., Wang, Q. Y., Dai, J., Liu, X., Huang, Y. J., Cai, H., Zhan, X. Y., Han, Q. Y., Wang, H., Chen, Y., Li, H. Y., Li, A. L., Zhang, X. M., Zhou, T., & Li, T. (2017). NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Molecular Cell, 68(1), 185\u2013197.e6. https:\/\/doi.org\/10.1016\/j.molcel.2017.08.017","journal-title":"Molecular Cell"},{"key":"2048_CR33","doi-asserted-by":"publisher","first-page":"119603","DOI":"10.1016\/j.bbamcr.2023.119603","volume":"1871","author":"D Chen","year":"2024","unstructured":"Chen, D., Wang, B., Zhao, Z., Zhang, G., Wang, P., Zhang, L., Liu, X., Zhang, H., Zeng, Q., & Wang, X. (2024). Modified 5-aminolevulinic acid photodynamic therapy induces cutaneous squamous cell carcinoma cell pyroptosis via the JNK signaling pathway. Biochimica et Biophysica Acta. Molecular Cell Research, 1871(1), 119603. https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119603","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"1","key":"2048_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00408-025-00850-2","volume":"203","author":"Y. Feng","year":"2025","unstructured":"Feng,Y., Weng, J., Li, C., Liu, Q., Chang, Q., Zhang, H., Li, M., Wang, K., Wang, X., Chung, K. F., Adcock, I. M., & Li, F. (2025). FUNDC1 Promoted Ferroptosis via JNK Pathway in Cigarette Smoking-Induced Chronic Obstructive Pulmonary Disease. Lung, 203(1), 95. https:\/\/doi.org\/10.1007\/s00408-025-00850-2","journal-title":"Lung"},{"key":"2048_CR35","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.1038\/s41598-017-03675-z","volume":"7","author":"D Cabrera","year":"2017","unstructured":"Cabrera, D., Wree, A., Povero, D., Sol\u00eds, N., Hernandez, A., Pizarro, M., Moshage, H., Torres, J., Feldstein, A. E., Cabello-Verrugio, C., Brandan, E., Barrera, F., Arab, J. P., & Arrese, M. (2017). Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis. Scientific Reports, 7(1), 3491. https:\/\/doi.org\/10.1038\/s41598-017-03675-z","journal-title":"Scientific Reports"},{"key":"2048_CR36","doi-asserted-by":"publisher","first-page":"153650","DOI":"10.1016\/j.phymed.2021.153650","volume":"91","author":"W Liu","year":"2021","unstructured":"Liu, W., Liang, L., Zhang, Q., Li, Y., Yan, S., Tang, T., Ren, Y., Mo, J., Liu, F., Chen, X., & Lan, T. (2021). Effects of andrographolide on renal tubulointersticial injury and fibrosis. Evidence of its mechanism of action. Phytomedicine, 91, 153650.https:\/\/doi.org\/10.1016\/j.phymed.2021.153650","journal-title":"Phytomedicine"},{"key":"2048_CR37","doi-asserted-by":"publisher","first-page":"112719","DOI":"10.1016\/j.intimp.2024.112719","volume":"139","author":"Y Qin","year":"2024","unstructured":"Qin, Y.,Li, W., Liu, J., Wang, F., Zhou, W., Xiao, L., Zhou, P., Wu, F., Chen, X., Xu, S., Liu, L., Xiao, X., & Zhang, D. (2024). Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE\/PI3K\/AKT\/mTOR pathway. International Immunopharmacology, 139, 112719. https:\/\/doi.org\/10.1016\/j.intimp.2024.112719","journal-title":"International Immunopharmacology"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02048-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02048-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02048-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:22:41Z","timestamp":1780482161000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02048-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2048"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02048-6","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"3 March 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}