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Marine macroalgae, including\n                    <jats:italic>Halymenia durvillaei<\/jats:italic>\n                    , are rich in bioactive compounds with promising therapeutic potential. H. durvillaei collected from North Sulawesi, Indonesia, was extracted with methanol and fractionated into n-hexane, chloroform, ethyl acetate, and aqueous fractions. Phytochemical profiling and cytotoxicity were assessed using the brine shrimp lethality test (15.625\u20131000 \u00b5g\/mL) and MTT assay against HeLa cells treated with extract fractions (0.125\u20132 mg\/mL) for 72 h. The most bioactive fraction was subjected to GC\u2013MS characterization. Major compounds identified were evaluated through molecular docking against Vaccinia H1-related phosphatase (VHR; PDB ID: 3F81) using AutoDock Vina\/CB-Dock2, followed by 100 ns molecular dynamics simulation and ADMET prediction. Phytochemical screening confirmed the presence of flavonoids (2.91 mg QE\/g), alkaloids (1.03 mg\/g), tannins, saponins, and steroids. The chloroform fraction exhibited the highest cytotoxicity (LC\u2085\u2080 = 33.83 \u00b5g\/mL), while ethyl acetate, n-hexane, chloroform, and aqueous fractions inhibited 70\u201393% of HeLa cell proliferation. GC\u2013MS analysis identified oleic acid as a major compound. In silico studies revealed stable binding of oleic acid to VHR phosphatase, a protein implicated in cervical cancer progression, supported by favorable ADMET properties. H. durvillaei demonstrates significant cytotoxic and antiproliferative activities, highlighting its potential as a source of natural anticancer agents. However, further compound isolation and mechanistic validation are required to confirm its therapeutic relevance.\n                  <\/jats:p>","DOI":"10.1007\/s12013-026-02099-9","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:15:14Z","timestamp":1781694914000},"page":"3981-4000","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic Activity of Halymenia durvillaei against Cervical Cancer Cells: In Vitro and Computational Evidence"],"prefix":"10.1007","volume":"84","author":[{"given":"Grace","family":"Sanger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena J.","family":"Damongilala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahrul","family":"Nurkolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"issue":"1","key":"2099_CR1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1186\/s12913-022-08984-2","volume":"22","author":"MC Eastment","year":"2022","unstructured":"Eastment, M. 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