{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:18:31Z","timestamp":1793837911808,"version":"4.6.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02131-y","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:36:12Z","timestamp":1786545372000},"page":"3273-3289","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferroptosis\u2013Inflammation Crosstalk: Mechanistic Insights and Emerging Drug Targets"],"prefix":"10.1007","volume":"84","author":[{"given":"Sanjivani","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayali","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"5","key":"2131_CR1","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., & Morrison, B. (2012). Ferroptosis: an iron-dependent form of nonapoptotic cell death. cell, 149(5), 1060\u20131072.","journal-title":"cell"},{"issue":"2","key":"2131_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell, B. R., Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gasc\u00f3n, S., Hatzios, S. K., Kagan, V. E., & Noel, K. (2017). Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell, 171(2), 273\u2013285.","journal-title":"Cell"},{"issue":"4","key":"2131_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang, X., Stockwell, B. R., & Conrad, M. (2021). Ferroptosis: mechanisms, biology and role in disease. Nature reviews Molecular cell biology, 22(4), 266\u2013282.","journal-title":"Nature reviews Molecular cell biology"},{"key":"2131_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","volume":"4","author":"S Feng","year":"2023","unstructured":"Feng, S., Tang, D., Wang, Y., Li, X., Bao, H., Tang, C., Dong, X., Li, X., Yang, Q., Yan, Y., Yin, Z., Shang, T., Zheng, K., Huang, X., Wei, Z., Wang, K., & Qi, S. (2023). The mechanism of ferroptosis and its related diseases. Mol Biomed, 4, 33 https:\/\/doi.org\/10.1186\/s43556-023-00142-2.","journal-title":"Mol Biomed"},{"issue":"1-2","key":"2131_CR5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., Brown, L. M., Girotti, A. W., Cornish, V. W., Schreiber, S. L., & Stockwell, B. R. (2014). Regulation of ferroptotic cancer cell death by GPX4. Cell, 156(1-2), 317\u2013331.","journal-title":"Cell"},{"issue":"12","key":"2131_CR6","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., Basavarajappa, D., R\u00e5dmark, O., Kobayashi, S., Seibt, T., Beck, H., Neff, F., Esposito, I., Wanke, R., F\u00f6rster, H., Yefremova, O., Heinrichmeyer, M., Bornkamm, G. W., Geissler, E. K., Thomas, S. B., Stockwell, B. R., O'Donnell, V. B., Kagan, V. E., Schick, J. A., & Conrad, M. (2014). Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol, 16(12), 1180\u20131191.","journal-title":"Nat Cell Biol"},{"issue":"7784","key":"2131_CR7","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., Bassik, M. C., Nomura, D. K., Dixon, S. J., & Olzmann, J. A. (2019). The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature, 575(7784), 688\u2013692.","journal-title":"Nature"},{"issue":"7860","key":"2131_CR8","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","volume":"593","author":"C Mao","year":"2021","unstructured":"Mao, C., Liu, X., Zhang, Y., Lei, G., Yan, Y., Lee, H., Koppula, P., Wu, S., Zhuang, L., Fang, B., Poyurovsky, M. V., Olszewski, K., & Gan, B. (2021). DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature, 593(7860), 586\u2013590.","journal-title":"Nature"},{"key":"2131_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05930-w","volume":"14","author":"Z Chen","year":"2023","unstructured":"Chen, Z., Wang, W., Abdul Razak, S. R., Han, T., Ahmad, N. H., & Li, X. (2023). Ferroptosis as a potential target for cancer therapy. Cell Death Dis, 14, 460 https:\/\/doi.org\/10.1038\/s41419-023-05930-w.","journal-title":"Cell Death Dis"},{"key":"2131_CR10","doi-asserted-by":"publisher","first-page":"645518","DOI":"10.3389\/fcell.2021.645518","volume":"9","author":"X Chen","year":"2021","unstructured":"Chen, X., Yu, C., Kang, R., & Tang, D. (2021). Iron metabolism in ferroptosis. Front Cell Dev Biol, 9, 645518 https:\/\/doi.org\/10.3389\/fcell.2021.645518.","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"2131_CR11","doi-asserted-by":"publisher","first-page":"100049","DOI":"10.1016\/j.clnves.2025.100049","volume":"1","author":"H Yan","year":"2025","unstructured":"Dai Z, Liu J, Zeng L, Shi K, Peng X, Jin Z, Zheng R, Zeng C. Targeting ferroptosis in cancer therapy: Mechanisms, strategies, and clinical applications. Cell Investigation. 2025;1(4):100049 https:\/\/doi.org\/10.1016\/j.clnves.2025.100049","journal-title":"Cell Investigation"},{"issue":"2","key":"2131_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","volume":"31","author":"D Tang","year":"2021","unstructured":"Tang, D., Chen, X., Kang, R., & Kroemer, G. (2021). Ferroptosis: molecular mechanisms and health implications. Cell Res, 31(2), 107\u2013125. https:\/\/doi.org\/10.1038\/s41422-020-00441-1.","journal-title":"Cell Res"},{"issue":"2","key":"2131_CR13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220864","volume":"220","author":"B Zhou","year":"2023","unstructured":"Zhou, B., Liu, J., Kang, R., Klionsky, D. J., & Tang, D. (2023). Ferroptosis in infection, inflammation, and immunity. J Exp Med, 220(2), e20220864 https:\/\/doi.org\/10.1084\/jem.20220864.","journal-title":"J Exp Med"},{"issue":"7755","key":"2131_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","volume":"569","author":"W Wang","year":"2019","unstructured":"Wang, W., Green, M., Choi, J. E., Gij\u00f3n, M., Kennedy, P. D., Johnson, J. K., Liao, P., Lang, X., Kryczek, I., Sell, A., Xia, H., Zhou, J., Li, G., Li, J., Li, W., Wei, S., Vatan, L., Zhang, H., Szeliga, W., & Zou, W. (2019). CD8\u207a T cells regulate tumour ferroptosis during cancer immunotherapy. Nature, 569(7755), 270\u2013274. https:\/\/doi.org\/10.1038\/s41586-019-1170-y.","journal-title":"Nature"},{"key":"2131_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05930-w","volume":"14","author":"T Xu","year":"2023","unstructured":"Chen, Z., Wang, W., Abdul Razak, S.R. et al. Ferroptosis as a potential target for cancer therapy. Cell Death Dis 14, 460 (2023). https:\/\/doi.org\/10.1038\/s41419-023-05930-w","journal-title":"Cell Death Dis"},{"issue":"2","key":"2131_CR16","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.12.011","volume":"59","author":"M Gao","year":"2016","unstructured":"Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2016). Glutaminolysis and transferrin regulate ferroptosis. Mol Cell, 59(2), 298\u2013308. https:\/\/doi.org\/10.1016\/j.molcel.2015.12.011.","journal-title":"Mol Cell"},{"issue":"8","key":"2131_CR17","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1183087","volume":"12","author":"W Hou","year":"2016","unstructured":"Hou, W., Xie, Y., Song, X., Sun, X., Lotze, M. T., Zeh, 3rd, H. J., Kang, R., & Tang, D. (2016). Autophagy promotes ferroptosis by degradation of ferritin. Autophagy, 12(8), 1425\u20131428. https:\/\/doi.org\/10.1080\/15548627.2016.1183087.","journal-title":"Autophagy"},{"issue":"7784","key":"2131_CR18","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., Mour\u00e3o, A., Buday, K., Sato, M., Wanninger, J., Vignane, T., Mohana, V., Rehberg, M., Flatley, A., Schepers, A., & Conrad, M. (2019). FSP1 is a glutathione-independent ferroptosis suppressor. Nature, 575(7784), 693\u2013698. https:\/\/doi.org\/10.1038\/s41586-019-1707-0.","journal-title":"Nature"},{"key":"2131_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-04622-1","volume":"15","author":"B Zhou","year":"2024","unstructured":"Zhou, B., Zhao, X., Shi, C., Li, Y., Liu, X., & Tang, D. (2024). Ferroptosis in health and disease: Mechanisms, regulation, and therapeutic opportunities. Cell Death Dis, 15, 142 https:\/\/doi.org\/10.1038\/s41419-024-04622-1.","journal-title":"Cell Death Dis"},{"issue":"5","key":"2131_CR20","first-page":"1301","volume":"184","author":"R Medzhitov","year":"2021","unstructured":"Medzhitov, R. (2021). Inflammation 2020: new adventures of an old flame. Cell, 184(5), 1301\u20131328.","journal-title":"Cell"},{"issue":"12","key":"2131_CR21","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","volume":"25","author":"D Furman","year":"2019","unstructured":"Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N., & Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nat Med, 25(12), 1822\u20131832.","journal-title":"Nat Med"},{"key":"2131_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu, T., Zhang, L., Joo, D., & Sun, S. C. (2017). NF-\u03baB signalling in inflammation. Signal Transduct Target Ther, 2, 17023.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2131_CR23","first-page":"1","volume":"32","author":"MS Hayden","year":"2022","unstructured":"Hayden, M. S., & Ghosh, S. (2022). NF-\u03baB in immunobiology. Cell Res, 32(1), 1\u201323.","journal-title":"Cell Res"},{"issue":"1","key":"2131_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2174\/0113894501320839240918110656","volume":"26","author":"M Mohan","year":"2025","unstructured":"Mohan, M., Mannan, A., Kakkar, C., & Singh, T. G. (2025). Nrf2 and ferroptosis: exploring translational avenues for therapeutic approaches to neurological diseases. Current Drug Targets, 26(1), 33\u201358.","journal-title":"Current Drug Targets"},{"issue":"4","key":"2131_CR25","first-page":"257","volume":"23","author":"JL Johnson","year":"2023","unstructured":"Johnson, J. L., Georgakopoulou, E. A., Gorgoulis, V. G., & Passos, J. F. (2023). Stress-induced inflammatory responses: roles in ageing and disease. Nat Rev Immunol, 23(4), 257\u2013273.","journal-title":"Nat Rev Immunol"},{"issue":"9","key":"2131_CR26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1056\/NEJMoa1405870","volume":"372","author":"JJ O\u2019Shea","year":"2015","unstructured":"O\u2019Shea, J. J., Holland, S. M., & Staudt, L. M. (2015). JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med, 372(9), 835\u2013845.","journal-title":"N Engl J Med"},{"key":"2131_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1482986","volume":"15","author":"B Jin","year":"2024","unstructured":"Jin, B., Zhang, Z., Zhang, Y., Yang, M., Wang, C., Xu, J., Zhu, Y., Mi, Y., Jiang, J., & Sun, Z. (2024). Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives. Frontiers in pharmacology, 15, 1482986.","journal-title":"Frontiers in pharmacology"},{"issue":"1","key":"2131_CR28","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41419-020-2256-z","volume":"11","author":"Z Hu","year":"2020","unstructured":"Hu, Z., Zhang, H., Yi, B., Yang, S., Liu, J., Hu, J., Wang, J., Cao, K., & Zhang, W. (2020). VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis. Cell death & disease, 11(1), 73.","journal-title":"Cell death & disease"},{"issue":"8","key":"2131_CR29","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson, K. V., Deng, M., & Ting, J. P. Y. (2019). The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol, 19(8), 477\u2013489.","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"2131_CR30","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/nri3863","volume":"15","author":"T Ganz","year":"2015","unstructured":"Ganz, T., & Nemeth, E. (2015). Iron homeostasis in host defence and inflammation. Nat Rev Immunol, 15(8), 500\u2013510.","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"2131_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04228-z","volume":"12","author":"X Mao","year":"2021","unstructured":"Mao, X., Ji, T., Liu, A., & Weng, Y. (2021). Emerging roles of ferroptosis in immune regulation and disease. Cell Death Dis, 12(11), 957.","journal-title":"Cell Death Dis"},{"issue":"7","key":"2131_CR32","first-page":"485","volume":"24","author":"C Mao","year":"2024","unstructured":"Mao, C., Gong, L., & Kang, W. (2024). Ferroptosis regulation and therapeutic strategies in cancer. Nat Rev Cancer, 24(7), 485\u2013502.","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"2131_CR33","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00011-022-01672-1","volume":"72","author":"L Deng","year":"2023","unstructured":"Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2023). Molecular mechanisms of ferroptosis and relevance to inflammation. Inflammation Research, 72(2), 281\u2013299.","journal-title":"Inflammation Research"},{"issue":"1","key":"2131_CR34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","volume":"13","author":"VE Kagan","year":"2017","unstructured":"Kagan, V. E., Mao, G., Qu, F., Angeli, J. P., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., Kapralov, A. A., Amoscato, A. A., Jiang, J., Anthonymuthu, T., Mohammadyani, D., Yang, Q., Proneth, B., Klein-Seetharaman, J., Watkins, S., & Bay\u0131r, H. (2017). Oxidized arachidonic and adrenic phosphatidylethanolamines navigate ferroptosis. Nat Chem Biol, 13(1), 81\u201390. https:\/\/doi.org\/10.1038\/nchembio.2238.","journal-title":"Nat Chem Biol"},{"issue":"1","key":"2131_CR35","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2026.2659414","volume":"48","author":"L Zeng","year":"2026","unstructured":"Zeng, L., Zhu, L., Xu, H., Li, Y., & Hu, K. (2026). Mitochondrial dysfunction\u2013ferroptosis crosstalk drives renal fibrosis in chronic kidney disease. Renal Failure, 48(1), 2659414.","journal-title":"Renal Failure"},{"issue":"3","key":"2131_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70643","volume":"16","author":"H Li","year":"2026","unstructured":"Li, H., Wang, W., Zhan, J., Xiao, Y., Chen, X., Su, C., & Zhu, P. (2026). The multifaceted roles of the ACSL family in cancer: metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling. Clinical and Translational Medicine, 16(3), e70643.","journal-title":"Clinical and Translational Medicine"},{"key":"2131_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1140791","volume":"14","author":"X Lv","year":"2023","unstructured":"Lv, X., Tang, W., Qin, J., Wang, W., Dong, J., & Wei, Y. (2023). The crosslinks between ferroptosis and autophagy in asthma. Frontiers in immunology, 14, 1140791.","journal-title":"Frontiers in immunology"},{"key":"2131_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1709561","volume":"16","author":"R Tu","year":"2025","unstructured":"Tu, R., Han, Z., Zhang, H., Jia, X., Sun, T., Liu, H., Li, J., Tang, M., & Wang, S. (2025). From pathogenesis to treatment: the emerging role of ferroptosis in parkinson\u2019s disease. Frontiers in Immunology, 16, 1709561.","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"2131_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04034-7","volume":"12","author":"L Xu","year":"2021","unstructured":"Xu, L., Xu, W., Li, D., Yu, X., Gao, F., Qin, Y., Yang, Y., & Zhao, S. (2021). Recent advances in ferroptosis and therapeutic targets of ferroptosis in cancer. Cell Death Dis, 12(8), 780.","journal-title":"Cell Death Dis"},{"issue":"10","key":"2131_CR40","first-page":"1239","volume":"23","author":"B Do Van","year":"2016","unstructured":"Do Van, B., Gouel, F., Jonneaux, A., Timmerman, K., Gel\u00e9, P., P\u00e9trault, M., Bastide, M., Laloux, C., Moreau, C., Bordet, R., Devos, D., & Devedjian, J. C. (2016). Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC. Cell Death Differ, 23(10), 1239\u20131248.","journal-title":"Cell Death Differ"},{"key":"2131_CR41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3389\/fimmu.2020.00599","volume":"11","author":"X Li","year":"2020","unstructured":"Li, X., Duan, L., Liu, C., Lei, G., Kang, R., & Tang, D. (2020). Ferroptosis: an emerging target for immunity and inflammation. Front Immunol, 11, 599.","journal-title":"Front Immunol"},{"issue":"1","key":"2131_CR42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2238","volume":"13","author":"VE Kagan","year":"2017","unstructured":"Kagan, V. E., Mao, G., Qu, F., Angeli, J. P., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., Kapralov, A. A., Amoscato, A. A., Jiang, J., Anthonymuthu, T., Mohammadyani, D., Yang, Q., Proneth, B., Klein-Seetharaman, J., Watkins, S., & Bay\u0131r, H. (2017). ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol, 13(1), 91\u201398. https:\/\/doi.org\/10.1038\/nchembio.2238.","journal-title":"Nat Chem Biol"},{"key":"2131_CR43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1273570","volume":"14","author":"K Maiese","year":"2023","unstructured":"Maiese, K. (2023). The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk. Frontiers in immunology, 14, 1273570.","journal-title":"Frontiers in immunology"},{"issue":"4","key":"2131_CR44","first-page":"145","volume":"17","author":"V Tavkar","year":"2025","unstructured":"Tavkar, V., Goyal, A., Kansal, H., Chopra, V., Garg, K., & Sharma, S. (2025). Targeting ferroptosis for therapeutic management of resistant cancers. J Young Pharm, 17(4), 145\u2013154.","journal-title":"J Young Pharm"},{"key":"2131_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1648432","volume":"16","author":"W Wang","year":"2025","unstructured":"Wang, W., Li, H., Liang, S., Hu, Y., Ding, J., Wu, X., & Hua, D. (2025). Bridging the gap: ferroptosis of immune cells in the tumor microenvironment. Frontiers in Immunology, 16, 1648432.","journal-title":"Frontiers in Immunology"},{"key":"2131_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110538","volume":"102","author":"L Yang","year":"2023","unstructured":"Yang, L., Chen, L., Chen, T., Gao, X., & Xiong, Y. (2023). The crosstalk between classic cell signaling pathways, non-coding RNAs and ferroptosis in drug resistance of tumors. Cellular Signalling, 102, 110538.","journal-title":"Cellular Signalling"},{"issue":"8","key":"2131_CR47","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.71138","volume":"30","author":"WY Zhao","year":"2026","unstructured":"Zhao, W. Y., Li, L. Y., Ye, F. W., & Zhao, J. W. (2026). The crosstalk mechanisms between ferroptosis and pyroptosis and their applications in diseases: from molecular networks to clinical strategies. Journal of Cellular and Molecular Medicine, 30(8), e71138.","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"7","key":"2131_CR48","first-page":"478","volume":"30","author":"WS Yang","year":"2020","unstructured":"Yang L, Chen L, Chen T, Gao X, Xiong Y. The crosstalk between classic cell signaling pathways, non-coding RNAs and ferroptosis in drug resistance of tumors. Cellular Signalling. 2023 Feb 1;102:110538.","journal-title":"Trends Cell Biol"},{"issue":"7","key":"2131_CR49","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41419-023-05969-9","volume":"14","author":"R Guo","year":"2023","unstructured":"Guo, R., Duan, J., Pan, S., Cheng, F., Qiao, Y., Feng, Q., Liu, D., & Liu, Z. (2023). The road from AKI to CKD: molecular mechanisms and therapeutic targets of ferroptosis. Cell death & disease, 14(7), 426.","journal-title":"Cell death & disease"},{"issue":"1","key":"2131_CR50","first-page":"101","volume":"29","author":"H Feng","year":"2022","unstructured":"Feng, H., & Stockwell, B. R. (2022). Unsolved mysteries: how does ferroptosis kill cells? Cell Death Differ, 29(1), 101\u2013112.","journal-title":"Cell Death Differ"},{"issue":"3","key":"2131_CR51","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","volume":"168","author":"MU Muckenthaler","year":"2017","unstructured":"Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017). A red carpet for iron metabolism. Cell, 168(3), 344\u2013361.","journal-title":"Cell"},{"issue":"4","key":"2131_CR52","first-page":"377","volume":"30","author":"D Tang","year":"2020","unstructured":"Tang, D., Chen, X., & Kroemer, G. (2020). Ferroptosis: molecular mechanisms and health implications. Cell Res, 30(4), 377\u2013387.","journal-title":"Cell Res"},{"issue":"1","key":"2131_CR53","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41392-025-02532-0","volume":"11","author":"X Chen","year":"2026","unstructured":"Chen, X., Zhang, J., Guo, L., Wu, C., Zhou, J., Xu, M., Mo, L., Li, Y., & He, J. (2026). Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies. Signal transduction and targeted therapy, 11(1), 82.","journal-title":"Signal transduction and targeted therapy"},{"issue":"2","key":"2131_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06503-1","volume":"15","author":"C Han","year":"2024","unstructured":"Han, C., Ge, M., Xing, P., Xia, T., Zhang, C., Ma, K., Ma, Y., Li, S., Li, W., Liu, X., Zhang, B., Zhang, L., & Zhang, L. (2024). Molecular mechanisms of ferroptosis in inflammation and disease. Cell Death Dis, 15(2), 145.","journal-title":"Cell Death Dis"},{"key":"2131_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1120519","volume":"14","author":"J Fan","year":"2023","unstructured":"Fan, J., Jiang, T., & He, D. (2023). Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases. Frontiers in Immunology, 14, 1120519.","journal-title":"Frontiers in Immunology"},{"issue":"7950","key":"2131_CR56","first-page":"332","volume":"615","author":"C Puig-Saus","year":"2023","unstructured":"Puig-Saus, C., Sennino, B., Peng, S., Wang, C. L., Pan, Z., Yuen, B., Purandare, B., An, D., Quach, B. B., Nguyen, D., Xia, H., Jilani, S., Shao, K., McHugh, C., Greer, J., Peabody, P., Nayak, S., Hoover, J., Said, S., & Ribas, A. (2023). CD8\u207a T cells regulate tumour ferroptosis during cancer immunotherapy. Nature, 615(7950), 332\u2013339.","journal-title":"Nature"},{"key":"2131_CR57","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06496-x","volume":"15","author":"L Shao","year":"2024","unstructured":"Shao, L., Kong, X., Lv, S., Shu, X., Ma, X., Ai, X., Yan, D., & Ying, Y. (2024). Mechanistic insights into ferroptosis regulation and disease therapy. Cell Death Dis, 15, 112.","journal-title":"Cell Death Dis"},{"issue":"9","key":"2131_CR58","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri3495","volume":"13","author":"JS Arthur","year":"2013","unstructured":"Arthur, J. S., & Ley, S. C. (2013). Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol, 13(9), 679\u2013692.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"2131_CR59","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70116","volume":"6","author":"D Guo","year":"2025","unstructured":"Guo, D., Cai, S., Deng, L., Xu, W., Fu, S., Lin, Y., Jiang, T., Li, Q., Shen, Z., Zhang, J., & Luo, P. (2025). Ferroptosis in pulmonary disease and lung cancer: molecular mechanisms, crosstalk regulation, and therapeutic strategies. MedComm, 6(3), e70116.","journal-title":"MedComm"},{"issue":"1","key":"2131_CR60","first-page":"47","volume":"36","author":"J Zhu","year":"2025","unstructured":"Zhu, J., Li, Y., Chen, X., Wang, H., Singh, A., & Kumar, R., et al. (2025). Targeting ferroptosis for treatment of metabolic disorders. Trends Endocrinol Metab, 36(1), 47\u201361.","journal-title":"Trends Endocrinol Metab"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02131-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02131-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02131-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:15:31Z","timestamp":1789632931000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02131-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["2131"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02131-y","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"4 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that AI tools were not used during the preparation of the manuscript.","order":1,"name":"Ethics","label":"Declaration for the Use of Generative AI in Scientific Writing","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}