{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:37Z","timestamp":1792783297617,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82304339"],"award-info":[{"award-number":["82304339"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Projects of Anhui Provincial Health Commission","award":["AHWJ2023A20506"],"award-info":[{"award-number":["AHWJ2023A20506"]}]},{"name":"Projects of Anhui University Natural Science Foundation","award":["KJ2021ZD0106"],"award-info":[{"award-number":["KJ2021ZD0106"]}],"id":[{"id":"https:\/\/ror.org\/05th6yx34","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02149-2","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:30:41Z","timestamp":1786699841000},"page":"4599-4611","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Insights into Aldose Reductase-Dependent Modulation of Hypoxia-Inducible Factor-1\u03b1 in Promoting Renal Fibrosis"],"prefix":"10.1007","volume":"84","author":[{"given":"Wenke","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"1","key":"2149_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00345-025-05580-x","volume":"43","author":"Y Khater","year":"2025","unstructured":"Khater, Y., Barakat, N., Shokeir, A., Samy, A., & Karrouf, G. (2025). Renal fibrosis progression following partial unilateral ureteral obstruction: mechanisms and therapeutic insights. World Journal of Urology, 43(1), 229. https:\/\/doi.org\/10.1007\/s00345-025-05580-x","journal-title":"World Journal of Urology"},{"issue":"1","key":"2149_CR2","doi-asserted-by":"publisher","first-page":"e23529","DOI":"10.1002\/dvg.23529","volume":"62","author":"S Hadpech","year":"2024","unstructured":"Hadpech, S., & Thongboonkerd, V. (2024). Epithelial-mesenchymal plasticity in kidney fibrosis. Genesis, 62(1), e23529. https:\/\/doi.org\/10.1002\/dvg.23529","journal-title":"Genesis"},{"key":"2149_CR3","doi-asserted-by":"publisher","first-page":"569322","DOI":"10.3389\/fphys.2020.569322","volume":"11","author":"L Sheng","year":"2020","unstructured":"Sheng, L., & Zhuang, S. (2020). New Insights Into the Role and Mechanism of Partial Epithelial-Mesenchymal Transition in Kidney Fibrosis. Frontiers in Physiology, 11, 569322. https:\/\/doi.org\/10.3389\/fphys.2020.569322","journal-title":"Frontiers in Physiology"},{"issue":"10","key":"2149_CR4","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3390\/metabo11100655","volume":"11","author":"M Singh","year":"2021","unstructured":"Singh, M., Kapoor, A., & Bhatnagar, A. (2021). Physiological and Pathological Roles of Aldose Reductase. Metabolites, 11(10), 655. https:\/\/doi.org\/10.3390\/metabo11100655","journal-title":"Metabolites"},{"issue":"11","key":"2149_CR5","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1080\/13543776.2024.2412573","volume":"34","author":"BL Bernardoni","year":"2024","unstructured":"Bernardoni, B. L., D\u2019Agostino, I., Scian\u00f2, F., & La Motta, C. (2024). The challenging inhibition of Aldose Reductase for the treatment of diabetic complications: a 2019\u20132023 update of the patent literature. Expert Opinion on Therapeutic Patents, 34(11), 1085\u20131103. https:\/\/doi.org\/10.1080\/13543776.2024.2412573","journal-title":"Expert Opinion on Therapeutic Patents"},{"issue":"1","key":"2149_CR6","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41401-018-0043-5","volume":"40","author":"J He","year":"2019","unstructured":"He, J., Gao, H. X., Yang, N., Zhu, X. D., Sun, R. B., Xie, Y., Zeng, C. H., Zhang, J. W., Wang, J. K., Ding, F., Aa, J. Y., & Wang, G. J. (2019). The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db\/db mice through metabolic modulation. Acta Pharmacologica Sinica, 40(1), 86\u201397. https:\/\/doi.org\/10.1038\/s41401-018-0043-5","journal-title":"Acta Pharmacologica Sinica"},{"key":"2149_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cbi.2017.01.017","volume":"276","author":"KC Chang","year":"2017","unstructured":"Chang, K. C., Shieh, B., & Petrash, J. M. (2017). Influence of aldose reductase on epithelial-to-mesenchymal transition signaling in lens epithelial cells. Chemico-Biological Interactions, 276, 149\u2013154. https:\/\/doi.org\/10.1016\/j.cbi.2017.01.017","journal-title":"Chemico-Biological Interactions"},{"issue":"5","key":"2149_CR8","doi-asserted-by":"publisher","first-page":"401","DOI":"10.4196\/kjpp.2015.19.5.401","volume":"19","author":"X Li","year":"2015","unstructured":"Li, X., Shen, Y., Lu, Y., & Yang, J. (2015). Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat. The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 19(5), 401\u2013411. https:\/\/doi.org\/10.4196\/kjpp.2015.19.5.401","journal-title":"The Korean Journal of Physiology & Pharmacology: Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology"},{"issue":"5","key":"2149_CR9","doi-asserted-by":"publisher","first-page":"156","DOI":"10.14715\/cmb\/2023.69.5.24","volume":"69","author":"Z Zhang","year":"2023","unstructured":"Zhang, Z., Li, Z., Chen, X., Wang, Y., & Li, X. (2023). Effect of AR gene-specific knockout on the process of radiation-induced pulmonary fibrosis and its mechanism. Cellular and Molecular Biology (Noisy-Le-Grand France), 69(5), 156\u2013162. https:\/\/doi.org\/10.14715\/cmb\/2023.69.5.24","journal-title":"Cellular and Molecular Biology (Noisy-Le-Grand France)"},{"key":"2149_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bbrc.2022.06.008","volume":"618","author":"D Liu","year":"2022","unstructured":"Liu, D., Sun, H., Li, K., Zhao, Z., Liu, Z., Zhang, G., Ge, Y., Zhang, J., Wang, D., & Leng, Y. (2022). HIF-1\u03b1 mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells. Biochemical and Biophysical Research Communications, 618, 15\u201323. https:\/\/doi.org\/10.1016\/j.bbrc.2022.06.008","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"4\u20136","key":"2149_CR11","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1089\/ars.2023.0467","volume":"42","author":"H Zhao","year":"2025","unstructured":"Zhao, H., Yang, M., Han, Y., Jiang, N., Liu, Y., Li, C., Yang, J., Luo, S., Liu, C., Sun, L., Liu, F., & Liu, Y. (2025). HIF-1\u03b1\/BNIP3-Mediated Endoplasmic Reticulum Degradation via Autophagy Protects Against Ischemia Reperfusion-Induced Acute Kidney Injury. Antioxidants & Redox Signaling, 42(4\u20136), 212\u2013227. https:\/\/doi.org\/10.1089\/ars.2023.0467","journal-title":"Antioxidants & Redox Signaling"},{"issue":"1","key":"2149_CR12","doi-asserted-by":"publisher","first-page":"2501757","DOI":"10.1080\/0886022X.2025.2501757","volume":"47","author":"ZT Li","year":"2025","unstructured":"Li, Z. T., Hu, X. H., Ni, W. J., Li, Z. L., Huang, B. K., Zhang, Y., Miao, A. F., & Cao, J. Y. (2025). Hypoxia-inducible factor-1\u03b1 promotes tubulointerstitial fibrosis via the upregulation of Muc4. Renal Failure, 47(1), 2501757. https:\/\/doi.org\/10.1080\/0886022X.2025.2501757","journal-title":"Renal Failure"},{"issue":"12","key":"2149_CR13","doi-asserted-by":"publisher","first-page":"3810","DOI":"10.1172\/JCI30487","volume":"117","author":"DF Higgins","year":"2007","unstructured":"Higgins, D. F., Kimura, K., Bernhardt, W. M., Shrimanker, N., Akai, Y., Hohenstein, B., Saito, Y., Johnson, R. S., Kretzler, M., Cohen, C. D., Eckardt, K. U., Iwano, M., & Haase, V. H. (2007). Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. The Journal of Clinical Investigation, 117(12), 3810\u20133820. https:\/\/doi.org\/10.1172\/JCI30487","journal-title":"The Journal of Clinical Investigation"},{"issue":"9","key":"2149_CR14","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/nm.3901","volume":"21","author":"MT Grande","year":"2015","unstructured":"Grande, M. T., S\u00e1nchez-Laorden, B., L\u00f3pez-Blau, C., De Frutos, C. A., Boutet, A., Ar\u00e9valo, M., Rowe, R. G., Weiss, S. J., L\u00f3pez-Novoa, J. M., & Nieto, M. A. (2015). Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nature Medicine, 21(9), 989\u2013997. https:\/\/doi.org\/10.1038\/nm.3901","journal-title":"Nature Medicine"},{"issue":"6","key":"2149_CR15","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.acthis.2019.06.005","volume":"121","author":"L Lu","year":"2019","unstructured":"Lu, L., Li, J., Le, Y., & Jiang, H. (2019). Inhibitor of growth 4 (ING4) inhibits hypoxia-induced EMT by decreasing HIF-1\u03b1 and snail in HK2 cells. Acta Histochemica, 121(6), 695\u2013703. https:\/\/doi.org\/10.1016\/j.acthis.2019.06.005","journal-title":"Acta Histochemica"},{"key":"2149_CR16","doi-asserted-by":"publisher","first-page":"112812","DOI":"10.1016\/j.intimp.2024.112812","volume":"140","author":"T Song","year":"2024","unstructured":"Song, T., Wang, R., Zhou, X., Chen, W., Chen, Y., Liu, Z., & Men, L. (2024). Metabolomics and molecular dynamics unveil the therapeutic potential of epalrestat in diabetic nephropathy. International Immunopharmacology, 140, 112812. https:\/\/doi.org\/10.1016\/j.intimp.2024.112812","journal-title":"International Immunopharmacology"},{"key":"2149_CR17","doi-asserted-by":"publisher","DOI":"10.4103\/mgr.MEDGASRES-D-25-00137","author":"MM Akl","year":"2026","unstructured":"Akl, M. M., & Ahmed, A. (2026). Glycohypoxia: a hypothesis linking chronic hyperglycemia to functional hypoxia and diabetic complications in type 2 diabetes. Medical Gas Research. https:\/\/doi.org\/10.4103\/mgr.MEDGASRES-D-25-00137. 10.4103\/mgr.MEDGASRES-D-25-00137. Advance online publication.","journal-title":"Medical Gas Research"},{"key":"2149_CR18","doi-asserted-by":"publisher","first-page":"101847","DOI":"10.1016\/j.mito.2024.101847","volume":"75","author":"H Wang","year":"2024","unstructured":"Wang, H., Luo, W., Chen, H., Cai, Z., & Xu, G. (2024). Mitochondrial dynamics and mitochondrial autophagy: Molecular structure, orchestrating mechanism and related disorders. Mitochondrion, 75, 101847. https:\/\/doi.org\/10.1016\/j.mito.2024.101847","journal-title":"Mitochondrion"},{"key":"2149_CR19","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.freeradbiomed.2019.12.005","volume":"152","author":"S Li","year":"2020","unstructured":"Li, S., Lin, Q., Shao, X., Zhu, X., Wu, J., Wu, B., Zhang, M., Zhou, W., Zhou, Y., Jin, H., Zhang, Z., Qi, C., Shen, J., Mou, S., Gu, L., & Ni, Z. (2020). Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction. Free Radical Biology & Medicine, 152, 632\u2013649. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.12.005","journal-title":"Free Radical Biology & Medicine"},{"issue":"5","key":"2149_CR20","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1080\/15548627.2023.2287930","volume":"20","author":"Y Wang","year":"2024","unstructured":"Wang, Y., Ping, Z., Gao, H., Liu, Z., Xv, Q., Jiang, X., & Yu, W. (2024). LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis. Autophagy, 20(5), 1114\u20131133. https:\/\/doi.org\/10.1080\/15548627.2023.2287930","journal-title":"Autophagy"},{"issue":"7","key":"2149_CR21","doi-asserted-by":"publisher","first-page":"167978","DOI":"10.1016\/j.bbadis.2025.167978","volume":"1871","author":"H Li","year":"2025","unstructured":"Li, H., Meng, P., Meng, Y., Yang, Y., Zheng, W., Huang, H., & Zhao, Z. (2025). Mechanism of ruxolitinib enhancing mitophagy against renal fibrosis via PINK1\/Parkin pathway. Biochimica et Biophysica Acta Molecular Basis of Disease, 1871(7), 167978. https:\/\/doi.org\/10.1016\/j.bbadis.2025.167978","journal-title":"Biochimica et Biophysica Acta Molecular Basis of Disease"},{"issue":"22","key":"2149_CR22","doi-asserted-by":"publisher","first-page":"12775","DOI":"10.1021\/acs.jafc.3c09634","volume":"72","author":"Y Cheng","year":"2024","unstructured":"Cheng, Y., Lu, Z., Mao, T., Song, Y., Qu, Y., Chen, X., Chen, K., Liu, K., & Zhang, C. (2024). Magnoflorine Ameliorates Chronic Kidney Disease in High-Fat and High-Fructose-Fed Mice by Promoting Parkin\/PINK1-Dependent Mitophagy to Inhibit NLRP3\/Caspase-1-Mediated Pyroptosis. Journal of Agricultural and Food Chemistry, 72(22), 12775\u201312787. https:\/\/doi.org\/10.1021\/acs.jafc.3c09634","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"10","key":"2149_CR23","doi-asserted-by":"publisher","first-page":"101284","DOI":"10.1016\/j.jpha.2025.101284","volume":"15","author":"Q Wu","year":"2025","unstructured":"Wu, Q., Zhao, Y., & Huang, F. (2025). Metformin alleviates renal tubular injury in diabetic kidney disease by activating mitophagy and inhibiting ferroptosis via HIF-1\u03b1\/MIOX axis. Journal of Pharmaceutical Analysis, 15(10), 101284. https:\/\/doi.org\/10.1016\/j.jpha.2025.101284","journal-title":"Journal of Pharmaceutical Analysis"},{"issue":"4","key":"2149_CR24","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12013-023-01176-7","volume":"81","author":"W Liu","year":"2023","unstructured":"Liu, W., Zhou, H., Dong, H., Xing, D., & Lu, M. (2023). Fluorofenidone Attenuates Renal Interstitial Fibrosis by Enhancing Autophagy and Retaining Mitochondrial Function. Cell Biochemistry and Biophysics, 81(4), 777\u2013785. https:\/\/doi.org\/10.1007\/s12013-023-01176-7","journal-title":"Cell Biochemistry and Biophysics"},{"key":"2149_CR25","doi-asserted-by":"publisher","first-page":"102946","DOI":"10.1016\/j.redox.2023.102946","volume":"68","author":"L Yao","year":"2023","unstructured":"Yao, L., Liang, X., Liu, Y., Li, B., Hong, M., Wang, X., Chen, B., Liu, Z., & Wang, P. (2023). Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K\/Akt\/eNOS signaling pathway in diabetic tubulopathy. Redox Biology, 68, 102946. https:\/\/doi.org\/10.1016\/j.redox.2023.102946","journal-title":"Redox Biology"},{"key":"2149_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2025.04.045","volume":"236","author":"J Wang","year":"2025","unstructured":"Wang, J., Shi, K., Xu, Q., Wang, H., Wang, Y., Liu, S., Jiang, W., Chen, R., Chen, Y., Zhang, Y., Wu, M., Li, X., & Li, C. (2025). Aldose reductase -mediated HUR ubiquitination enhances exosome release and hepatic fibrosis via ROS\/PI3K\/AKT pathway. Free Radical Biology & Medicine, 236, 1\u201316. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.04.045","journal-title":"Free Radical Biology & Medicine"},{"key":"2149_CR27","doi-asserted-by":"publisher","first-page":"155913","DOI":"10.1016\/j.metabol.2024.155913","volume":"155","author":"X Zhao","year":"2024","unstructured":"Zhao, X., Li, Y., Yu, J., Teng, H., Wu, S., Wang, Y., Zhou, H., & Li, F. (2024). Role of mitochondria in pathogenesis and therapy of renal fibrosis. Metabolism: Clinical and Experimental, 155, 155913. https:\/\/doi.org\/10.1016\/j.metabol.2024.155913","journal-title":"Metabolism: Clinical and Experimental"},{"issue":"4","key":"2149_CR28","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1152\/physrev.00027.2022","volume":"103","author":"R N\u00f8rregaard","year":"2023","unstructured":"N\u00f8rregaard, R., Mutsaers, H. A. M., Fr\u00f8ki\u00e6r, J., & Kwon, T. H. (2023). Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis. Physiological Reviews, 103(4), 2827\u20132872. https:\/\/doi.org\/10.1152\/physrev.00027.2022","journal-title":"Physiological Reviews"},{"issue":"11","key":"2149_CR29","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/ki.2009.86","volume":"75","author":"RL Chevalier","year":"2009","unstructured":"Chevalier, R. L., Forbes, M. S., & Thornhill, B. A. (2009). Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney International, 75(11), 1145\u20131152. https:\/\/doi.org\/10.1038\/ki.2009.86","journal-title":"Kidney International"},{"issue":"Pt 2","key":"2149_CR30","doi-asserted-by":"publisher","first-page":"135761","DOI":"10.1016\/j.ijbiomac.2024.135761","volume":"280","author":"S Ahmad","year":"2024","unstructured":"Ahmad, S., Ahmad, M. F. A., Khan, S., Alouffi, S., Khan, M., Prakash, C., Khan, M. W. A., & Ansari, I. A. (2024). Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities. International Journal of Biological Macromolecules, 280(Pt 2), 135761. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.135761","journal-title":"International Journal of Biological Macromolecules"},{"key":"2149_CR31","doi-asserted-by":"publisher","first-page":"7950457","DOI":"10.1155\/2020\/7950457","volume":"2020","author":"X Zhou","year":"2020","unstructured":"Zhou, X., Liu, Z., Ying, K., Wang, H., Liu, P., Ji, X., Chi, T., Zou, L., Wang, S., & He, Z. (2020). WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling. Oxidative Medicine and Cellular Longevity, 2020, 7950457. https:\/\/doi.org\/10.1155\/2020\/7950457","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"29","key":"2149_CR32","doi-asserted-by":"publisher","first-page":"18252","DOI":"10.1021\/acs.jafc.5c01904","volume":"73","author":"X Mei","year":"2025","unstructured":"Mei, X., Zhang, Q., Shao, W., Zheng, J., Zhao, P., & Li, J. (2025). Targeted Inhibition of Aldose Reductase by Isoliquiritigenin Suppresses Fatty Acid Synthesis to Inhibit Macrophage M2 Polarization and Alleviate Pulmonary Fibrosis. Journal of Agricultural and Food Chemistry, 73(29), 18252\u201318267. https:\/\/doi.org\/10.1021\/acs.jafc.5c01904","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"2149_CR33","doi-asserted-by":"publisher","first-page":"696542","DOI":"10.3389\/fcell.2021.696542","volume":"9","author":"Y Zhang","year":"2021","unstructured":"Zhang, Y., Jin, D., Kang, X., Zhou, R., Sun, Y., Lian, F., & Tong, X. (2021). Signaling Pathways Involved in Diabetic Renal Fibrosis. Frontiers in Cell and Developmental Biology, 9, 696542. https:\/\/doi.org\/10.3389\/fcell.2021.696542","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"1","key":"2149_CR34","doi-asserted-by":"publisher","first-page":"10695","DOI":"10.1038\/s41598-025-94918-x","volume":"15","author":"Q Lu","year":"2025","unstructured":"Lu, Q., Liu, J., Xiong, Y., Jian, J., Wang, J., Chen, Z., Wan, S., Liu, X., & Wang, L. (2025). Cyanidin-3-glucoside upregulated NDRG2 through the PI3K\/AKT pathway to alleviate EMT and ECM in renal fibrosis. Scientific Reports, 15(1), 10695. https:\/\/doi.org\/10.1038\/s41598-025-94918-x","journal-title":"Scientific Reports"},{"key":"2149_CR35","doi-asserted-by":"publisher","first-page":"3076131","DOI":"10.1155\/2020\/3076131","volume":"2020","author":"CX Li","year":"2020","unstructured":"Li, C. X., Wang, H. W., Jiang, W. J., Li, G. C., Zhang, Y. D., Luo, C. H., & Li, X. C. (2020). The Inhibition of Aldose Reductase Accelerates Liver Regeneration through Regulating Energy Metabolism. Oxidative Medicine and Cellular Longevity, 2020, 3076131. https:\/\/doi.org\/10.1155\/2020\/3076131","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"2149_CR36","doi-asserted-by":"publisher","first-page":"927329","DOI":"10.3389\/fendo.2022.927329","volume":"13","author":"X Wei","year":"2022","unstructured":"Wei, X., Hou, Y., Long, M., Jiang, L., & Du, Y. (2022). Molecular mechanisms underlying the role of hypoxia-inducible factor-1 \u03b1 in metabolic reprogramming in renal fibrosis. Frontiers in Endocrinology, 13, 927329. https:\/\/doi.org\/10.3389\/fendo.2022.927329","journal-title":"Frontiers in Endocrinology"},{"issue":"14","key":"2149_CR37","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.2174\/1871520622666220204115151","volume":"22","author":"R Nivetha","year":"2022","unstructured":"Nivetha, R., Arvindh, S., Baba, A. B., Gade, D. R., Gopal, G., Reddy, K. C., Reddy, K. P., G. B., & Nagini, S. (2022). Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1\/PI3K\/Akt Signalling. Anti-Cancer Agents in Medicinal Chemistry, 22(14), 2619\u20132636. https:\/\/doi.org\/10.2174\/1871520622666220204115151","journal-title":"Anti-Cancer Agents in Medicinal Chemistry"},{"issue":"6","key":"2149_CR38","doi-asserted-by":"publisher","first-page":"F1105","DOI":"10.1152\/ajprenal.00285.2020","volume":"319","author":"M Jiang","year":"2020","unstructured":"Jiang, M., Bai, M., Lei, J., Xie, Y., Xu, S., Jia, Z., & Zhang, A. (2020). Mitochondrial dysfunction and the AKI-to-CKD transition. American Journal of Physiology Renal Physiology, 319(6), F1105\u2013F1116. https:\/\/doi.org\/10.1152\/ajprenal.00285.2020","journal-title":"American Journal of Physiology Renal Physiology"},{"issue":"1","key":"2149_CR39","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11255-023-03686-y","volume":"56","author":"J Sun","year":"2024","unstructured":"Sun, J., Liu, C., Liu, Y. Y., & Guo, Z. A. (2024). Mitophagy in Renal Interstitial Fibrosis. International Urology and Nephrology, 56(1), 167\u2013179. https:\/\/doi.org\/10.1007\/s11255-023-03686-y","journal-title":"International Urology and Nephrology"},{"issue":"6","key":"2149_CR40","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1039\/d4fo06043a","volume":"16","author":"F Yang","year":"2025","unstructured":"Yang, F., Gao, Y., Xie, S., Yang, W., Wang, Q., Ye, W., Sun, L., Zhou, J., & Feng, X. (2025). Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota. Food & Function, 16(6), 2316\u20132334. https:\/\/doi.org\/10.1039\/d4fo06043a","journal-title":"Food & Function"},{"key":"2149_CR41","doi-asserted-by":"publisher","first-page":"176376","DOI":"10.1016\/j.ejphar.2024.176376","volume":"967","author":"L Yang","year":"2024","unstructured":"Yang, L., Xu, L., Hao, X., Song, Z., Zhang, X., Liu, P., Wang, S., He, Z., & Zou, L. (2024). An aldose reductase inhibitor, WJ-39, ameliorates renal tubular injury in diabetic nephropathy by activating PINK1\/Parkin signaling. European Journal of Pharmacology, 967, 176376. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176376","journal-title":"European Journal of Pharmacology"},{"key":"2149_CR42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2147\/HMER.S546357","volume":"17","author":"J Yan","year":"2025","unstructured":"Yan, J., Zhao, W., Wang, H., Zhou, L., Li, X., & Wang, G. (2025). Aldose Reductase Mediated Mitophagy Promotes Epithelial-Mesenchymal Transition of Hepatocytes. Hepatic Medicine: Evidence and Research, 17, 141\u2013159. https:\/\/doi.org\/10.2147\/HMER.S546357","journal-title":"Hepatic Medicine: Evidence and Research"},{"key":"2149_CR43","doi-asserted-by":"publisher","unstructured":"Sang, X. Y., Xiao, J. J., Liu, Q., Zhu, R., Dai, J. J., Zhang, C., Yu, H., Yang, S. J., & Zhang, B. F. (2020). Regulators of calcineurin 1 deficiency attenuates tubulointerstitial fibrosis through improving mitochondrial fitness. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 34(11) https:\/\/doi.org\/10.1096\/fj.202000781RRR","DOI":"10.1096\/fj.202000781RRR"},{"issue":"1","key":"2149_CR44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41538-025-00654-x","volume":"10","author":"Y Wu","year":"2025","unstructured":"Wu, Y., Chen, C., Xie, J., Chang, X., Zhang, Y., Zheng, Y., Yuan, Y., Hu, W., & Xie, X. (2025). Haematococcus pluvialis ameliorates renal fibrosis by restoring mitophagy via PINK1-Parkin-p62-LC3 signaling. NPJ Science of Food, 10(1), 9. https:\/\/doi.org\/10.1038\/s41538-025-00654-x","journal-title":"NPJ Science of Food"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02149-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02149-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02149-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:13:42Z","timestamp":1789632822000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02149-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["2149"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02149-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9850390\/v1","asserted-by":"object"}]},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"4 August 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The animal study protocol was approved by the Animal Welfare and Ethics Committee of Wannan Medical University approved all animal experiments (Approval number: WNMC-AWE-2023182).","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Conflict of Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}