{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:06:30Z","timestamp":1789747590161,"version":"4.0.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02175-0","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:31:32Z","timestamp":1789745492000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["River Water Quality Modulates Lupeol Targeting of HIF-1\u03b1\/VEGF and PI3K\/Akt Signaling Pathways in Triple-Negative Breast Cancer Cells"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7183-4510","authenticated-orcid":false,"given":"Cletus Anes","family":"Ukwubile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy Salvia","family":"Malgwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatus Obiajulu","family":"Onwuegbunam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahamefula Anslem","family":"Ahuchaogu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Oise","family":"Ikpefan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"2175_CR1","doi-asserted-by":"publisher","unstructured":"Sultan, M. H., Moni, S. S., Madkhali, O. A., Bakkari, M. A., Alshahrani, S., Alqahtani, S. S. (2022). Characterization of cisplatin-loaded chitosan nanoparticles and rituximab-linked surfaces as target-specific injectable nano-formulations for combating cancer. Sci Rep [Internet]. ;12:1\u201316. Available from: https:\/\/doi.org\/10.1038\/s41598-021-04427-w","DOI":"10.1038\/s41598-021-04427-w"},{"key":"2175_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.30574\/gscbps.2022.19.3.0209","volume":"19","author":"J Mindi\u00e9diba","year":"2022","unstructured":"Mindi\u00e9diba, J., Bangou, A. M., & Emmanuel Thiombiano (2022). Mouniratou Habibou Sibdou Ouedraogo, Georges Anicet Ouedraogo. Inhibition of prostate cancer by plant extracts used in the treatment of malaria in Burkina Faso. GSC Biol Pharm Sci, 19, 100\u2013108.","journal-title":"GSC Biol Pharm Sci"},{"key":"2175_CR3","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jaim.2016.07.004","volume":"7","author":"AF Majdalawieh","year":"2016","unstructured":"Majdalawieh, A. F., & Fayyad, M. W. (2016). Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. J Ayurveda Integr Med, 7, 173\u2013180.","journal-title":"J Ayurveda Integr Med"},{"key":"2175_CR4","doi-asserted-by":"publisher","unstructured":"Sharma, M., Kashyap, N., Verma, M., Devi, B., Prashar, A., & Sinha, S. (2024). Role of natural products in cancer management: a comprehensive review. www.cornous.com J Ethnopharmacol Toxicol Rev Artic [Internet]. ;2020:1\u201318. Available from: https:\/\/doi.org\/10.37446\/jet\/ra\/2.1.2024.1-18","DOI":"10.37446\/jet\/ra\/2.1.2024.1-18"},{"key":"2175_CR5","doi-asserted-by":"publisher","first-page":"5375","DOI":"10.2147\/DDDT.S275007","volume":"14","author":"SY Lee","year":"2020","unstructured":"Lee, S. Y., Kim, C. Y., & Nam, T. G. (2020). Ruthenium complexes as anticancer agents: A brief history and perspectives. Drug Design, Development And Therapy, 14, 5375\u20135392.","journal-title":"Drug Design, Development And Therapy"},{"key":"2175_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2025.1594901","volume":"16","author":"LA AlMousa","year":"2025","unstructured":"AlMousa, L. A., Pandey, P., Lakhanpal, S., Kyada, A. K., Malathi, H., Nayak, P. P., et al. (2025). An updated review deciphering the anticancer potential of pentacyclic triterpene lupeol and its nanoformulations. Frontiers In Pharmacology, 16, 1\u201320.","journal-title":"Frontiers In Pharmacology"},{"key":"2175_CR7","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3390\/cancers16010114","volume":"16","author":"V Jim\u00e9nez-Gonz\u00e1lez","year":"2023","unstructured":"Jim\u00e9nez-Gonz\u00e1lez, V., Kowalczyk, T., Piekarski, J., Szemraj, J., Rijo, P., & Sitarek, P. (2023). Nature\u2019s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family. Cancers (Basel), 16, 114.","journal-title":"Cancers (Basel)"},{"key":"2175_CR8","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jsps.2019.09.008","volume":"27","author":"A Ahmad","year":"2019","unstructured":"Ahmad, A., Mishra, R. K., Vyawahare, A., Kumar, A., Rehman, M. U., Qamar, W., et al. (2019). Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive\/anticancer agent: Chemistry and biological effects. Saudi Pharm J, 27, 1113\u20131126.","journal-title":"Saudi Pharm J"},{"key":"2175_CR9","doi-asserted-by":"crossref","unstructured":"Niu, Z., He, J., Wang, S., Xue, B., Zhang, H., & Hou, R. (2025). Targeting Glycolysis for Treatment of Breast Cancer Resistance: Current Progress and Future Prospects. 21(6), 2589\u20132605. https:\/\/doi:10.7150\/ijbs.109803","DOI":"10.7150\/ijbs.109803"},{"key":"2175_CR10","doi-asserted-by":"publisher","unstructured":"Miyashita-Ishiwata, M., El Sabeh, M., Afrin, S., & Borahay, M. A. (2021). Hypoxia Induces Angiogenesis and Proliferation in Uterine Fibroid Cells. Fertil Steril [Internet]. ;116:e12. Available from: https:\/\/doi.org\/10.1016\/j.fertnstert.2021.07.041","DOI":"10.1016\/j.fertnstert.2021.07.041"},{"key":"2175_CR11","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1177\/1947601911423654","volume":"2","author":"BL Krock","year":"2011","unstructured":"Krock, B. L., Skuli, N., & Simon, M. C. (2011). Hypoxia-Induced Angiogenesis: Good and Evil. Genes and Cancer, 2, 1117\u20131133.","journal-title":"Genes and Cancer"},{"key":"2175_CR12","doi-asserted-by":"publisher","unstructured":"Song, Z., Liu, Y., Dai, S., Yin, S., Zeng, Y., Liu, Y. (2025). The integration strategy of Didang decoction against cerebral ischemia-reperfusion injury : Regulation of apoptosis-autophagy-inflammation network and validation of PI3K \/ Akt pathway. J Ethnopharmacol [Internet]. ;353:120277. Available from: https:\/\/doi.org\/10.1016\/j.jep.2025.120277","DOI":"10.1016\/j.jep.2025.120277"},{"key":"2175_CR13","doi-asserted-by":"publisher","unstructured":"Ojo, O. A., Amanze, J. C., Oni, A. I., Grant, S., Iyobhebhe, M., Elebiyo, T. C. (2022). Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K\/AKT signaling pathway. Sci Rep [Internet]. ;12:1\u201317. Available from: https:\/\/doi.org\/10.1038\/s41598-022-07015-8","DOI":"10.1038\/s41598-022-07015-8"},{"key":"2175_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-018-2241-6","volume":"18","author":"S Paramee","year":"2018","unstructured":"Paramee, S., Sookkhee, S., Sakonwasun, C., Na Takuathung, M., Mungkornasawakul, P., Nimlamool, W., et al. (2018). Anti-cancer effects of Kaempferia parviflora on ovarian cancer SKOV3 cells. Bmc Complementary And Alternative Medicine, 18, 1\u201313.","journal-title":"Bmc Complementary And Alternative Medicine"},{"key":"2175_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3329\/ralf.v3i1.27858","volume":"3","author":"K Mohiuddin","year":"2016","unstructured":"Mohiuddin, K., Alam, M. M., Rahman, M. S., Islam, M. S., & Ahmed, I. (2016). Effect of polluted river water on growth, yield and heavy metal accumulation of red amaranth. Res Agric Livest Fish, 3, 53\u201365.","journal-title":"Res Agric Livest Fish"},{"key":"2175_CR16","first-page":"13","volume":"17","author":"LK Kiambi","year":"2024","unstructured":"Kiambi, L. K., Nyambaka, H., & Gichumbi, J. M. (2024). Physico-Chemical Parameters and Water Quality along Mutonga River in Tharaka Nithi County. Kenya, 17, 13\u201325.","journal-title":"Kenya"},{"key":"2175_CR17","unstructured":"Ugbeyide, J. A., & Ugwumba, O. A. (2021). Water quality and phytoplankton as indicators of pollution in Ibuya river. Br J Environ Sci [Internet]. ;9:26\u201339. Available from: https:\/\/www.researchgate.net\/profile\/Nwonumara-Nkwuda\/publication\/325108327_Water_Quality_and_Phytoplankton_as_Indicators_of_Pollution_in_a_Tropical_River\/links\/5af753a60f7e9b026bd9f3af\/Water-Quality-and-Phytoplankton-as-Indicators-of-Pollution-in-a-Tropi"},{"key":"2175_CR18","doi-asserted-by":"crossref","unstructured":"IA, A., AB, O., OA, P., & A-AT, A. (2018). O. DA, A. OT. Water Pollution: Effects, Prevention, and Climatic Impact. Water Challenges an Urban World.","DOI":"10.5772\/intechopen.72018"},{"key":"2175_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/bjp.2008.31","volume":"153","author":"HP Rang","year":"2008","unstructured":"Rang, H. P. (2008). Life Sciences. British Journal Of Pharmacology, 153, 219\u2013221.","journal-title":"British Journal Of Pharmacology"},{"key":"2175_CR20","doi-asserted-by":"crossref","unstructured":"Navarrete, A., Katragunta, K., Balderas-L\u00f3pez, J. L., Avula, B., & Khan, I. A. (2024). Chemical profiling and quantification of flavones in several Pseudognaphalium and Gnaphalium species of Mexican gordolobo using UHPLC\/PDA\/MS. Journal Of Pharmaceutical And Biomedical Analysis, 245, 116186. https:\/\/10.1016\/j.jpba.2024.116186","DOI":"10.1016\/j.jpba.2024.116186"},{"key":"2175_CR21","doi-asserted-by":"crossref","unstructured":"Siudem, P., Zieli\u0144ska, A., & Paradowska, K. (2022). Application of 1H NMR in the study of fatty acids composition of vegetable oils. J Pharm Biomed Anal [Internet]. ;212:114658. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0731708522000796","DOI":"10.1016\/j.jpba.2022.114658"},{"issue":"4","key":"2175_CR22","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3390\/pr8040410","volume":"8","author":"ME Di Pietro","year":"2020","unstructured":"Di Pietro, M. E., Mannu, A., & Mele, A. (2020). NMR determination of free fatty acids in vegetable oils. Processes, 8(4), 410. https:\/\/10.3390\/pr8040410","journal-title":"Processes"},{"key":"2175_CR23","unstructured":"Khathi, M. T., Farhood, A. T., & Issmer, A. H. (2016). Determination of some heavy metals in extraction of plants by using AAS Technique. J Nat Sci Res [Internet]. ;6:130\u20137. Available from: https:\/\/www.iiste.org\/Journals\/index.php\/JNSR\/article\/view\/30202"},{"key":"2175_CR24","first-page":"114","volume":"1","author":"B OE","year":"2017","unstructured":"OE, B. (2017). OS A. Determination of Heavy Metal Profile in Bottled Water and Sachet Water Samples Obtained From Various Markets in Lagos, Nigeria. Environ Pollut Clim Chang, 1, 114. https:\/\/10.4172\/2573-458X.1000114","journal-title":"Environ Pollut Clim Chang"},{"key":"2175_CR25","doi-asserted-by":"publisher","first-page":"307","DOI":"10.4103\/2221-1691.261822","volume":"9","author":"N Mongalo","year":"2019","unstructured":"Mongalo, N., Soyingbe, O., & Makhafola, T. (2019). Antimicrobial, cytotoxicity, anticancer and antioxidant activities of Jatropha zeyheri Sond. roots (Euphorbiaceae). Asian Pac J Trop Biomed, 9, 307\u2013314.","journal-title":"Asian Pac J Trop Biomed"},{"key":"2175_CR26","doi-asserted-by":"publisher","first-page":"202","DOI":"10.59566\/IJBS.2010.6202","volume":"6","author":"H Yang","year":"2010","unstructured":"Yang, H., Zhang, N., Zeng, Q., Yu, Q., Ke, S., & Li, X. (2010). HPLC method for the simultaneous determination of ten annonaceous acetogenins after supercritical fluid CO2 extraction. International Journal Of Biomedical Sciences, 6, 202\u2013207.","journal-title":"International Journal Of Biomedical Sciences"},{"key":"2175_CR27","first-page":"50","volume":"62","author":"T Bennett","year":"2020","unstructured":"Bennett, T., & Solutions, R. (2020). Impact of Water Quality on Livestock. ;62:50.","journal-title":"Impact of Water Quality on Livestock"},{"key":"2175_CR28","doi-asserted-by":"publisher","unstructured":"Sissolak, B., Zabik, C., Saric, N., Sommeregger, W., Uhl, K. V., & Striedner, G. (2019). Application of the Bradford Assay for Cell Lysis Quanti fi cation : Residual Protein Content in Cell Culture Supernatants. Biotechnol J [Internet]. ;14. Available from: https:\/\/doi.org\/10.1002\/biot.201800714","DOI":"10.1002\/biot.201800714"},{"key":"2175_CR29","first-page":"51046","volume":"88","author":"CR Justus","year":"2014","unstructured":"Justus, C. R., Leffler, N., Ruiz-Echevarria, M., & Yang, L. V. (2014). In vitro cell migration and invasion assays. Journal of Visualized Experiments, 88, 51046. https:\/\/10.3791\/51046","journal-title":"Journal Of Visualized Experiments"},{"key":"2175_CR30","first-page":"1250","volume":"20","author":"F Duzagac","year":"2015","unstructured":"Duzagac, F., Inan, S., Simsek, F. E., Acikgoz, E., Guven, U., Khan, S. A., et al. (2015). JAK\/STAT pathway interacts with intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) while prostate cancer stem cells form tumor spheroids. Journal Of B.U.On. : Official Journal Of The Balkan Union Of Oncology, 20, 1250\u20131257.","journal-title":"Journal Of B.U.On. : Official Journal Of The Balkan Union Of Oncology"},{"key":"2175_CR31","doi-asserted-by":"publisher","unstructured":"Hanna, D. H., Al-Atmani, A. K., AlRashidi, A. A., Shafee, E., & El (2024). Camellia sinensis methanolic leaves extract: Phytochemical analysis and anticancer activity against human liver cancer cells. PLoS One [Internet]. ;19:e0309795. Available from: https:\/\/doi.org\/10.1371\/journal.pone.0309795","DOI":"10.1371\/journal.pone.0309795"},{"key":"2175_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2024.1483856","volume":"15","author":"G Moriasi","year":"2024","unstructured":"Moriasi, G., Ngugi, M., Mwitari, P., & Omwenga, G. (2024). In vitro anti-prostate cancer efficacy and phytochemical composition of the dichloromethane and ethyl acetate leaf extracts of Vitex doniana (sweet). Frontiers In Pharmacology, 15, 1\u201313.","journal-title":"Frontiers In Pharmacology"},{"issue":"4","key":"2175_CR33","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/bios14040156","volume":"14","author":"J Petiti","year":"2024","unstructured":"Petiti, J., Revel, L., & Divieto, C. (2024). Standard Operating Procedure to Optimize Resazurin-Based Viability Assays. Biosensors, 14(4), 156. https:\/\/doi.org\/10.3390\/bios14040156","journal-title":"Biosensors"},{"key":"2175_CR34","doi-asserted-by":"publisher","unstructured":"Ismail, K. M., Hassan, S. S., & Hanna, D. H. (2025). Palladium-Imidazole Nanoparticles\u2019 Cytotoxic Effects on Colon Cancer Cells: Induction of Cell Cycle Arrest and Apoptosis Mediated via Mitochondria. Appl Organomet Chem [Internet]. ;39:e7908. Available from: https:\/\/doi.org\/10.1002\/aoc.7908","DOI":"10.1002\/aoc.7908"},{"key":"2175_CR35","doi-asserted-by":"publisher","unstructured":"Alfuraydi, A. A., Aziz, I. M., & Almajhdi, F. N. (2024). Assessment of antioxidant, anticancer, and antibacterial activities of the rhizome of ginger (Zingiber officinale). J King Saud Univ - Sci [Internet]. ;36:103112. Available from: https:\/\/doi.org\/10.1016\/j.jksus.2024.103112","DOI":"10.1016\/j.jksus.2024.103112"},{"key":"2175_CR36","doi-asserted-by":"crossref","unstructured":"Komakech, R., Yim, N. H., Shim, K. S., Jung, H., Byun, J. E., Lee, J. (2022). Root Extract of a Micropropagated Prunus africana Medicinal Plant Induced Apoptosis in Human Prostate Cancer Cells (PC-3) via Caspase-3 Activation. Evidence-based Complement Altern Med. ;2022.","DOI":"10.1155\/2022\/8232851"},{"key":"2175_CR37","doi-asserted-by":"crossref","unstructured":"Yonglitthipagon, P., Pairojkul, C., Chamgramol, Y., Mulvenna, J., & Sripa, B. (2010). Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. Int J Parasitol [Internet]. ;40:1203\u201312. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0020751910001773","DOI":"10.1016\/j.ijpara.2010.05.002"},{"key":"2175_CR38","unstructured":"Badal, S., Delgoda, R., & Pharmacognosy (Eds.). (2017). ited by."},{"key":"2175_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-018-2338-y","volume":"18","author":"M Moniruzzaman","year":"2018","unstructured":"Moniruzzaman, M., Mannan, M. A., Hossen Khan, M. F., Abir, A. B., & Afroze, M. (2018). The leaves of Crataeva nurvala Buch-Ham. modulate locomotor and anxiety behaviors possibly through GABAergic system. Bmc Complementary And Alternative Medicine, 18, 1\u201312.","journal-title":"Bmc Complementary And Alternative Medicine"},{"key":"2175_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/fishes8120583","volume":"8","author":"SJ Woo","year":"2023","unstructured":"Woo, S. J., Joo, M. S., Kim, S. S., Yoo, H. K., & Park, J. J. (2023). Histopathological and Immunohistochemical Features and Expression Patterns of Cytochrome p450 1 Family Genes in Black Rockfish (Sebastes schlegelii): Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin and \u03b2-Naphthoflavone. Fishes, 8, 1\u201315.","journal-title":"Fishes"},{"key":"2175_CR41","doi-asserted-by":"publisher","unstructured":"Ren, L., Ruan, X., Dong, H., Cheng, Y., Shon, K., Chang, C. (2025). The bitter flavor of Banxia Xiexin decoction activates TAS2R38 to ameliorate low-grade inflammation in the duodenum of mice with functional dyspepsia. J Ethnopharmacol [Internet]. ;341:119309. Available from: https:\/\/doi.org\/10.1016\/j.jep.2024.119309","DOI":"10.1016\/j.jep.2024.119309"},{"key":"2175_CR42","doi-asserted-by":"crossref","unstructured":"Jahan, I., Saha, P., Eysha Chisty, T. T., Mitu, K. F., Chowdhury, F. I., Ahmed, K. S. (2023). Crataeva nurvala Bark (Capparidaceae) Extract Modulates Oxidative Stress-Related Gene Expression, Restores Antioxidant Enzymes, and Prevents Oxidative Stress in the Kidney and Heart of 2K1C Rats. Evidence-Based Complement Altern Med. ;2023.","DOI":"10.1155\/2023\/4720727"},{"key":"2175_CR43","doi-asserted-by":"publisher","unstructured":"Jummah, N., Satrialdi, S., Artarini, A. A., Anindyajati, A., & Mudhakir, D. (2024). NLC delivery of EGFP plasmid to TM4 cell nuclei for targeted gene therapy. Adv Pharm Bull [Internet]. ;14:613\u201322. Available from: https:\/\/doi.org\/10.34172\/apb.2024.050","DOI":"10.34172\/apb.2024.050"},{"key":"2175_CR44","first-page":"1","volume":"13","author":"L Liu","year":"2025","unstructured":"Liu, L., Yu, J., Liu, Y., Xie, L., Hu, F., & Liu, H. (2025). Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors. Front Cell Dev Biol, 13, 1\u201321.","journal-title":"Front Cell Dev Biol"},{"issue":"7","key":"2175_CR45","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3390\/biom11070982","volume":"11","author":"A Janaszak-jasiecka","year":"2021","unstructured":"Janaszak-jasiecka, A., Siekierzycka, A., P\u0142oska, A., Dobrucki, I. T., & Kalinowski, L. (2021). Endothelial dysfunction driven by hypoxia\u2014the influence of oxygen deficiency on no bioavailability. Biomolecules, 11(7), 982. https:\/\/10.3390\/biom11070982","journal-title":"Biomolecules"},{"key":"2175_CR46","doi-asserted-by":"publisher","unstructured":"Saidurrahman, M., Mujahid, M., Siddiqui, M. A., Alsuwayt, B., & Rahman, M. A. (2022). Evaluation of hepatoprotective activity of ethanolic extract of Pterocarpus marsupium Roxb. leaves against paracetamol-induced liver damage via reduction of oxidative stress. Phytomedicine Plus [Internet]. ;2:100311. Available from: https:\/\/doi.org\/10.1016\/j.phyplu.2022.100311","DOI":"10.1016\/j.phyplu.2022.100311"},{"key":"2175_CR47","doi-asserted-by":"publisher","unstructured":"Utispan, K., Koontongkaew, S., & Niyomtham, N. (2023). Heliyon Ethanolic extract of Ocimum sanctum leaf modulates oxidative stress, cell cycle and apoptosis in head and neck cancer cell lines. Heliyon [Internet]. ;9:e15518. Available from: https:\/\/doi.org\/10.1016\/j.heliyon.2023.e15518","DOI":"10.1016\/j.heliyon.2023.e15518"},{"key":"2175_CR48","first-page":"359","volume":"7","author":"VF Doherty","year":"2010","unstructured":"Doherty, V. F., Ogunkuade, O. O., & Kanife, U. C. (2010). Biomarkers of Oxidative Stress and Heavy Metal Levels as Indicators of Environmental Pollution in Some Selected Fishes in Lagos, Nigeria. J Agric Environ Sci, 7, 359\u2013365.","journal-title":"J Agric Environ Sci"},{"key":"2175_CR49","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1021\/acs.jchemed.2c00966","volume":"100","author":"HN Lynch","year":"2023","unstructured":"Lynch, H. N., Authement, C. C., Maczko, A., Parker, M., Beaty, K., & Liyana Pathiranage, A. (2023). Gas Chromatography-Mass Spectrometry Analysis of Cannabis: Undergraduate Organic Chemistry Laboratory Exercise. Journal Of Chemical Education, 100, 1303\u20131312.","journal-title":"Journal Of Chemical Education"},{"key":"2175_CR50","doi-asserted-by":"publisher","unstructured":"Gr\u00fcnwald, M., Francis, G., & Esatbeyoglu, T. (2025). Evaluation of the genotoxic potential and minimisation of antinutrients in edible Xuta (Jatropha curcas L.) kernels. Food Chem Toxicol [Internet]. ;204:115624. Available from: https:\/\/doi.org\/10.1016\/j.fct.2025.115624","DOI":"10.1016\/j.fct.2025.115624"},{"issue":"3","key":"2175_CR51","first-page":"7","volume":"2","author":"M Hussainzadeh","year":"2024","unstructured":"Hussainzadeh, M. (2024). Synthesis of GO-PAM nanoparticles modifiers for the surface properties enhancement of water treatment membranes. Material Chemistry and Mechanics, 2(3), 7\u201314. https:\/\/10.22034\/mcm.2024.3.2","journal-title":"Material Chemistry and Mechanics"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02175-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02175-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02175-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:31:38Z","timestamp":1789745498000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02175-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":51,"alternative-id":["2175"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02175-0","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"30 August 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study did not involve human participants, clinical samples, or experimental animals. All experiments were conducted using commercially available authenticated human cancer cell lines (ATCC) in accordance with institutional biosafety and laboratory guidelines.","order":1,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing Interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}