{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:58:20Z","timestamp":1790377100858,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004491","name":"Balikesir \u00dcniversitesi","doi-asserted-by":"publisher","award":["BAP-2023\/023"],"award-info":[{"award-number":["BAP-2023\/023"]}],"id":[{"id":"10.13039\/501100004491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell Biochem Biophys"],"DOI":"10.1007\/s12013-026-02178-x","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:42:12Z","timestamp":1790329332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cell-Type-Dependent Responses to Oleuropein in MDA-MB-231 Breast Cancer Cells and HUVECs"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6758-8556","authenticated-orcid":false,"given":"Derya","family":"Okuyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-7152","authenticated-orcid":false,"given":"Ayla Solmaz","family":"Avc\u0131kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"issue":"5","key":"2178_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: The next generation. Cell, 144(5), 646\u2013674.","journal-title":"Cell"},{"key":"2178_CR2","doi-asserted-by":"publisher","first-page":"103851","DOI":"10.1016\/j.breast.2024.103851","volume":"79","author":"L Liao","year":"2025","unstructured":"Liao, L. (2025). Inequality in breast cancer: Global statistics from 2022 to 2050. The Breast, 79, 103851.","journal-title":"The Breast"},{"issue":"1","key":"2178_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10726-4","volume":"23","author":"E Liu","year":"2023","unstructured":"Liu, E., Zhang, F., Xu, T., Ye, L., Ma, S. S. Q., & Ji, Z. S. (2023). Relationship between tumor microbiota transcriptional activity and gene expression in breast cancer. BMC Cancer, 23(1), 252.","journal-title":"BMC Cancer"},{"issue":"1","key":"2178_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-022-00492-0","volume":"8","author":"T Qing","year":"2022","unstructured":"Qing, T., Karn, T., Rozenblit, M., Foldi, J., Marczyk, M., Shan, N. L., Blenman, K., Holtrich, U., Kalinsky, K., Meric-Bernstam, F., & Pusztai, L. (2022). Molecular differences between younger versus older ER-positive and HER2-negative breast cancers. NPJ Breast Cancer, 8(1), 119.","journal-title":"NPJ Breast Cancer"},{"key":"2178_CR5","doi-asserted-by":"publisher","first-page":"102375","DOI":"10.1016\/j.ctrv.2022.102375","volume":"105","author":"AJ Kerr","year":"2022","unstructured":"Kerr, A. J., Dodwell, D., McGale, P., Holt, F., Duane, F., Mannu, G., Darby, S. C., & Taylor, C. W. (2022). Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality. Cancer treatment reviews, 105, 102375.","journal-title":"Cancer treatment reviews"},{"issue":"3","key":"2178_CR6","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/antiox12030586","volume":"12","author":"MB Madureira","year":"2023","unstructured":"Madureira, M. B., Concato, V. M., Cruz, E., Bitencourt de Morais, J. M., Inoue, F., Concimo Santos, N., Gon\u00e7alves, M. D., Cremer de Souza, M., Basso Scandolara, T., Fontana Mezoni, M., Galvani, M., Rodrigues Ferreira Seiva, F., Panis, C., Miranda-Sapla, M. M., & Pavanelli, W. R. (2023). Naringenin and hesperidin as promising alternatives for prevention and co-adjuvant therapy for breast cancer. Antioxidants, 12(3), 586.","journal-title":"Antioxidants"},{"key":"2178_CR7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2147\/JEP.S528132","volume":"17","author":"IA Al Khalily","year":"2025","unstructured":"Al Khalily, I. A., Megantara, S., & Aulifa, D. L. (2025). Targeting molecular pathways in breast cancer using plant-derived bioactive compounds: a comprehensive review. Journal of Experimental Pharmacology, 17, 375\u2013401.","journal-title":"Journal of Experimental Pharmacology"},{"issue":"11","key":"2178_CR8","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3390\/antiox8120578","volume":"8","author":"C Nediani","year":"2019","unstructured":"Nediani, C., Ruzzolini, J., Romani, A., & Calorini, L. (2019). Oleuropein as a preventive and therapeutic agent in non-communicable diseases. Antioxidants, 8(11), 578.","journal-title":"Antioxidants"},{"issue":"3","key":"2178_CR9","first-page":"2673","volume":"17","author":"K Al-Asmari","year":"2020","unstructured":"Al-Asmari, K., Al-Attar, A., Mohamed, I., & Zeid, A. (2020). Potential health benefits and components of olive oil: An overview. Bioscience Research, 17(3), 2673\u20132687.","journal-title":"Bioscience Research"},{"issue":"4","key":"2178_CR10","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1161\/01.ATV.0000062884.69432.A0","volume":"23","author":"MA Carluccio","year":"2003","unstructured":"Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M., Scoditti, E., Storelli, C., Visioli, F., Distante, A., & De Caterina, R. (2003). Polyphenols from olive oil and red wine inhibit endothelial activation. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(4), 622\u2013629.","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"17","key":"2178_CR11","doi-asserted-by":"publisher","first-page":"8798","DOI":"10.1021\/jf901280r","volume":"57","author":"H Jemai","year":"2009","unstructured":"Jemai, H., & Sayadi, S. (2009). Antidiabetic and antioxidant effects of hydroxytyrosol and oleuropein. Journal of Agricultural and Food Chemistry, 57(17), 8798\u20138804.","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"10","key":"2178_CR12","first-page":"797","volume":"52","author":"MT Khayyal","year":"2002","unstructured":"Khayyal, M. T., El-Ghazaly, M. A., Abdallah, D. M., Nassar, N. N., Okpanyi, S. N., & Kreuter, M. H. (2002). Antihypertensive effect of olive leaf extract in rats. Arzneimittelforschung, 52(10), 797\u2013802.","journal-title":"Arzneimittelforschung"},{"issue":"2\u20133","key":"2178_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.antiviral.2005.02.005","volume":"66","author":"V Micol","year":"2005","unstructured":"Micol, V., Caturla, N., P\u00e9rez-Fons, L., M\u00e1s, V., P\u00e9rez, L., & Estepa, A. (2005). Antiviral activity of olive leaf extract against VHSV. Antiviral Research, 66(2\u20133), 129\u2013136.","journal-title":"Antiviral Research"},{"issue":"9\u201310","key":"2178_CR14","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0924-2244(00)00068-6","volume":"11","author":"A Saija","year":"2000","unstructured":"Saija, A., & Uccella, N. (2000). Olive biophenols: Functional effects on human wellbeing. Trends in Food Science & Technology, 11(9\u201310), 357\u2013363.","journal-title":"Trends in Food Science & Technology"},{"issue":"6","key":"2178_CR15","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3390\/nu16060818","volume":"16","author":"M Gon\u00e7alves","year":"2024","unstructured":"Gon\u00e7alves, M., Aiello, A., Rodr\u00edguez-P\u00e9rez, M., Accardi, G., Burgos-Ramos, E., & Silva, P. (2024). Olive oil components as novel antioxidants in neuroblastoma treatment: Exploring the therapeutic potential of oleuropein and hydroxytyrosol. Nutrients, 16(6), 818.","journal-title":"Nutrients"},{"issue":"9","key":"2178_CR16","doi-asserted-by":"publisher","first-page":"e70976","DOI":"10.1002\/fsn3.70976","volume":"13","author":"MJ Anwar","year":"2025","unstructured":"Anwar, M. J., Anwar, M. H., Imran, M., Noman, A. M., Hussain, M., Raza, H., Mohamed, H. M., Mohamed, G. A., Ibrahim, S., Yehuala, T. F., Alsagaby, S. A., Al Abdulmonem, W., Abdelgawad, M. A., Mostafa, E. M., Ghoneim, M. M., & Selim, S. (2025). Olive oil polyphenols: a promising approach for cancer prevention and therapy. Food Science & Nutrition, 13(9), e70976.","journal-title":"Food Science & Nutrition"},{"issue":"1","key":"2178_CR17","first-page":"10.9734","volume":"16","author":"R Liman","year":"2017","unstructured":"Liman, R., \u00c7oban, F., Ci\u011ferci, \u0130., Bulduk, \u0130., & Bozkurt, S. (2017). Antiangiogenic and apoptotic effects of oleuropein on breast cancer cells. British Journal of Pharmaceutical Research, 16(1), 10.9734.","journal-title":"British Journal of Pharmaceutical Research"},{"key":"2178_CR18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.fct.2012.12.009","volume":"53","author":"MH Elamin","year":"2013","unstructured":"Elamin, M. H., Daghestani, M. H., Omer, S. A., Elobeid, M. A., Virk, P., Al-Olayan, E. M., Hassan, Z. K., Mohammed, O. B., & Aboussekhra, A. (2013). Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food and Chemical Toxicology, 53, 310\u2013316.","journal-title":"Food and Chemical Toxicology"},{"key":"2178_CR19","doi-asserted-by":"publisher","first-page":"105880","DOI":"10.1016\/j.jff.2023.105880","volume":"110","author":"S Han","year":"2023","unstructured":"Han, S., Hou, H., Zhang, Y., Fang, Z., Li, Y., Zhang, L., Wang, Y., Zhang, S., Zhang, H., Jin, Q., Wu, G., & Wang, X. (2023). Oleuropein and its hydrolysate from extra virgin olive oil inhibit breast cancer cells proliferation interfering with the PI3K-AKT signal pathway. Journal of Functional Foods, 110, 105880.","journal-title":"Journal of Functional Foods"},{"issue":"3","key":"2178_CR20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.31989\/ffhd.v15i3.1577","volume":"15","author":"Y Haffani","year":"2025","unstructured":"Haffani, Y., Torkhani, M., Ben Halim, N., Chrigui, S., Ben Mami, N., Boudhrioua, N., Safra, I., & Darmoul, D. (2025). Oleuropein exhibits anticancer effects by inducing apoptosis and inhibiting cell motility in MCF7 and MDA-MB231 breast cancer cells. Functional Foods in Health and Disease, 15(3), 162\u2013175.","journal-title":"Functional Foods in Health and Disease"},{"issue":"12","key":"2178_CR21","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.3390\/molecules21121634","volume":"21","author":"Y Ci","year":"2016","unstructured":"Ci, Y., Qiao, J., & Han, M. (2016). Mechanisms of natural polyphenols interfering with breast cancer metastasis. Molecules, 21(12), 1634.","journal-title":"Molecules"},{"issue":"4","key":"2178_CR22","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.3892\/or.2016.4978","volume":"36","author":"M Liu","year":"2016","unstructured":"Liu, M., Wang, J., Huang, B., Chen, A., & Li, X. (2016). Oleuropein inhibits the proliferation and invasion of glioma cells via suppression of the AKT signaling pathway. Oncology reports, 36(4), 2009\u20132016.","journal-title":"Oncology reports"},{"issue":"1","key":"2178_CR23","doi-asserted-by":"publisher","first-page":"12994","DOI":"10.3390\/cimb46110774","volume":"46","author":"D Okuyan","year":"2024","unstructured":"Okuyan, D. (2024). EGF downregulates CAIII in colon cancer. Current Issues in Molecular Biology, 46(1), 12994\u201313002.","journal-title":"Current Issues in Molecular Biology"},{"issue":"2","key":"2178_CR24","doi-asserted-by":"publisher","first-page":"531","DOI":"10.21448\/ijsm.1821104","volume":"13","author":"D Okuyan","year":"2026","unstructured":"Okuyan, D. (2026). Apoptosis-related gene modulation by Juglans regia leaf extract in breast and colon cancer cells. International Journal of Secondary Metabolite, 13(2), 531\u2013538.","journal-title":"International Journal of Secondary Metabolite"},{"key":"2178_CR25","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1007\/s12013-026-02102-3","volume":"84","author":"D Okuyan","year":"2026","unstructured":"Okuyan, D., Akta\u015f, H., Poyrazl\u0131, F., & T\u00fcrko\u011flu, S. A. (2026). The dual role of TGF-\u03b2 and hypoxia on MMP14-Mediated invasion in PC3 cells. Cell Biochemistry and Biophysics, 84, 4025\u20134034.","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"12","key":"2178_CR26","doi-asserted-by":"publisher","first-page":"2797","DOI":"10.1007\/s12013-024-01396-5","volume":"82","author":"F Poyrazl\u0131","year":"2024","unstructured":"Poyrazl\u0131, F., Okuyan, D., K\u00f6\u00e7kar, F., & T\u00fcrko\u011flu, S. A. (2024). Hypoxic regulation of KLK4 gene under TGF-\u03b2. Cell Biochemistry and Biophysics, 82(12), 2797\u20132812.","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"4","key":"2178_CR27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J., & Schmittgen, T. D. (2001). Analysis using the 2\u2212\u0394\u0394CT method. Methods, 25(4), 402\u2013408.","journal-title":"Methods"},{"issue":"3","key":"2178_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s10616-026-00972-2","volume":"78","author":"S Aydo\u011fan T\u00fcrko\u011flu","year":"2026","unstructured":"Aydo\u011fan T\u00fcrko\u011flu, S., Toprak, C., Poyrazl\u0131, F., & Okuyan, D. (2026). The role of hypoxia in the regulation of serotonergic signaling: an investigation of HTR1B and TPH-1 expression in colorectal cancer and C. elegans models. Cytotechnology, 78(3), 105.","journal-title":"Cytotechnology"},{"issue":"4","key":"2178_CR29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s10616-025-00815-6","volume":"77","author":"S Aydo\u011fan T\u00fcrko\u011flu","year":"2025","unstructured":"Aydo\u011fan T\u00fcrko\u011flu, S., Okuyan, D., & K\u00f6\u00e7kar, F. (2025). The reducing effect of TNF-\u03b1 on carbonic anhydrase III gene expression in colon carcinoma and osteosarcoma cells. Cytotechnology, 77(4), 148.","journal-title":"Cytotechnology"},{"issue":"4","key":"2178_CR30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.55730\/1300-0152.2753","volume":"49","author":"S Aydo\u011fan T\u00fcrko\u011flu","year":"2025","unstructured":"Aydo\u011fan T\u00fcrko\u011flu, S., Bozkurt, A., Poyrazli, F., & Okuyan, D. (2025). Different hypoxic response of human CAVII and Caenorhabditis elegans homologous genes CAH-3, CAH-4, CAH-5. Turkish Journal of Biology, 49(4), 367\u2013379.","journal-title":"Turkish Journal of Biology"},{"issue":"14","key":"2178_CR31","doi-asserted-by":"publisher","first-page":"6894","DOI":"10.3390\/ijms26146894","volume":"26","author":"M Ho\u0142ota","year":"2025","unstructured":"Ho\u0142ota, M., & Posmyk, M. M. (2025). Nature-inspired strategies in cancer management: The potential of plant extracts in modulating tumour biology. International Journal of Molecular Sciences, 26(14), 6894.","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"2178_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.63626\/0m87x035","volume":"1","author":"UU Iqbal","year":"2024","unstructured":"Iqbal, U. U., Shafiq, N., Saeed, S., & Shahzad, M. A. (2024). Ribosome inactivating plant protein mediated regulation of transcriptomic profile in liver cancer cells. Cancer Research and Medicine, 1(2), 75\u201382.","journal-title":"Cancer Research and Medicine"},{"issue":"1","key":"2178_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12263-010-0177-7","volume":"6","author":"M Notarnicola","year":"2011","unstructured":"Notarnicola, M., Pisanti, S., Tutino, V., Bocale, D., Rotelli, M. T., Gentile, A., Memeo, V., Bifulco, M., Perri, E., & Caruso, M. G. (2011). Olive oil polyphenols and fatty acid synthase in colorectal cancer cells. Genes & Nutrition, 6(1), 63\u201369.","journal-title":"Genes & Nutrition"},{"issue":"6","key":"2178_CR34","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.3892\/mmr.2015.3266","volume":"11","author":"CM Yan","year":"2015","unstructured":"Yan, C. M., Chai, E. Q., Cai, H. Y., Miao, G. Y., & Ma, W. (2015). Oleuropein induces apoptosis in HepG2 cells. Molecular Medicine Reports, 11(6), 4617\u20134624.","journal-title":"Molecular Medicine Reports"},{"issue":"4","key":"2178_CR35","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s13105-012-0177-8","volume":"68","author":"M Alirezaei","year":"2012","unstructured":"Alirezaei, M., Dezfoulian, O., Neamati, S., Rashidipour, M., Tanideh, N., & Kheradmand, A. (2012). Oleuropein prevents ethanol-induced ulcers in rats. Journal of Physiology and Biochemistry, 68(4), 583\u2013592.","journal-title":"Journal of Physiology and Biochemistry"},{"issue":"4","key":"2178_CR36","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.foodchem.2011.02.025","volume":"127","author":"S Bulotta","year":"2011","unstructured":"Bulotta, S., Corradino, R., Celano, M., D\u2019Agostino, M., Maiuolo, J., Oliverio, M., Procopio, A., Iannone, M., Rotiroti, D., & Russo, D. (2011). Antiproliferative and antioxidant effects of oleuropein derivatives. Food Chemistry, 127(4), 1609\u20131614.","journal-title":"Food Chemistry"},{"issue":"1","key":"2178_CR37","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3390\/molecules22050705","volume":"22","author":"A Ahmad Farooqi","year":"2017","unstructured":"Ahmad Farooqi, A., Fayyaz, S., Silva, A. S., Sureda, A., Nabavi, S. F., Mocan, A., Nabavi, S. M., & Bishayee, A. (2017). Oleuropein and cancer chemoprevention. Molecules, 22(1), 705.","journal-title":"Molecules"},{"issue":"1","key":"2178_CR38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.gene.2016.03.038","volume":"585","author":"M Se\u00e7me","year":"2016","unstructured":"Se\u00e7me, M., Ero\u011flu, C., Dodurga, Y., & Ba\u011fc\u0131, G. (2016). Oleuropein effects on cell cycle and apoptosis in neuroblastoma. Gene, 585(1), 93\u201399.","journal-title":"Gene"},{"issue":"2","key":"2178_CR39","doi-asserted-by":"publisher","first-page":"842","DOI":"10.3390\/ijms24010842","volume":"24","author":"S Scicchitano","year":"2023","unstructured":"Scicchitano, S., Vecchio, E., Battaglia, A. M., Oliverio, M., Nardi, M., Procopio, A., Costanzo, F., Biamonte, F., & Faniello, M. C. (2023). Dual role of oleuropein in ovarian cancer. International Journal of Molecular Sciences, 24(2), 842.","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"2178_CR40","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.molcel.2010.01.025","volume":"37","author":"JE Chipuk","year":"2010","unstructured":"Chipuk, J. E., Moldoveanu, T., Llambi, F., Parsons, M. J., & Green, D. R. (2010). The BCL-2 family. Molecular Cell, 37(3), 299\u2013310.","journal-title":"Molecular Cell"},{"issue":"9","key":"2178_CR41","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1038\/cdd.2011.17","volume":"18","author":"PN Kelly","year":"2011","unstructured":"Kelly, P. N., & Strasser, A. (2011). Roles of the BCL-2 family in cancer. Cell Death & Differentiation, 18(9), 1414\u20131424.","journal-title":"Cell Death & Differentiation"},{"issue":"1","key":"2178_CR42","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I","volume":"183","author":"J Slingerland","year":"2000","unstructured":"Slingerland, J., & Pagano, M. (2000). Regulation of p27 in cancer. Journal of Cellular Physiology, 183(1), 10\u201317.","journal-title":"Journal of Cellular Physiology"},{"issue":"9","key":"2178_CR43","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1128\/MCB.22.9.2993-3002.2002","volume":"22","author":"S Ciarallo","year":"2002","unstructured":"Ciarallo, S., Subramaniam, V., Hung, W., Lee, J. H., Kotchetkov, R., Sandhu, C., Milic, A., & Slingerland, J. M. (2002). Altered p27Kip1 phosphorylation and function. Molecular and Cellular Biology, 22(9), 2993\u20133002.","journal-title":"Molecular and Cellular Biology"},{"issue":"6","key":"2178_CR44","doi-asserted-by":"publisher","first-page":"394","DOI":"10.4161\/cc.1.6.263","volume":"1","author":"G Viglietto","year":"2002","unstructured":"Viglietto, G., Motti, M. L., & Fresco, A. (2002). p27Kip1 deregulation in cancer. Cell Cycle, 1(6), 394\u2013400.","journal-title":"Cell Cycle"}],"container-title":["Cell Biochemistry and Biophysics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02178-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12013-026-02178-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12013-026-02178-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:01:19Z","timestamp":1790373679000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12013-026-02178-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":44,"alternative-id":["2178"],"URL":"https:\/\/doi.org\/10.1007\/s12013-026-02178-x","relation":{},"ISSN":["1559-0283"],"issn-type":[{"value":"1559-0283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2 September 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}